Carolyn L. Cummins, Ph.D. - Publications

Affiliations: 
2002 University of California, San Francisco, San Francisco, CA 
Area:
Pharmaceutical Chemistry, Pharmacology

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Huroy S, Kanawaty A, Magomedova L, Cummins CL, George SR, van der Kooy D, Henderson JT. Corrigendum to "EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function" [Behav. Brain Res. 300 (2016) 85-96]. Behavioural Brain Research. PMID 27134075 DOI: 10.1016/j.bbr.2016.04.021  0.92
2016 Bashiri A, Nesan D, Tavallaee G, Sue-Chue-Lam I, Chien K, Maguire GF, Naples M, Zhang J, Magomedova L, Adeli K, Cummins CL, Ng DS. Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis. Biochimica Et Biophysica Acta. PMID 27090939 DOI: 10.1016/j.bbalip.2016.04.005  0.92
2015 Ahmed S, Bott D, Gomez A, Tamblyn L, Rasheed A, MacPherson L, Sugamori KS, Cho T, Yang Y, Grant DM, Cummins CL, Matthews J. Loss of the Mono-ADP-Ribosyltransferase, TIPARP, Increases Sensitivity to Dioxin-Induced Steatohepatitis and Lethality. The Journal of Biological Chemistry. PMID 25975270 DOI: 10.1074/jbc.M115.660100  0.92
2015 Magomedova L, Cummins CL. Glucocorticoids and Metabolic Control. Handbook of Experimental Pharmacology. PMID 25917083 DOI: 10.1007/164_2015_1  0.92
2015 Gilbert RE, Thai K, Advani SL, Cummins CL, Kepecs DM, Schroer SA, Woo M, Zhang Y. SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes. Diabetologia. 58: 819-27. PMID 25563725 DOI: 10.1007/s00125-014-3485-4  0.92
2015 Patel R, Bookout AL, Magomedova L, Owen BM, Consiglio GP, Shimizu M, Zhang Y, Mangelsdorf DJ, Kliewer SA, Cummins CL. Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop Molecular Endocrinology. 29: 213-223. DOI: 10.1210/me.2014-1259  0.92
2014 Patel R, Williams-Dautovich J, Cummins CL. Minireview: New molecular mediators of glucocorticoid receptor activity in metabolic tissues Molecular Endocrinology. 28: 999-1011. PMID 24766141 DOI: 10.1210/me.2014-1062  0.92
2014 Lee AY, St Onge RP, Proctor MJ, Wallace IM, Nile AH, Spagnuolo PA, Jitkova Y, Gronda M, Wu Y, Kim MK, Cheung-Ong K, Torres NP, Spear ED, Han MK, Schlecht U, ... ... Cummins CL, et al. Mapping the cellular response to small molecules using chemogenomic fitness signatures. Science (New York, N.Y.). 344: 208-11. PMID 24723613 DOI: 10.1126/science.1250217  0.92
2014 Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS. Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol. Gastroenterology. 146: 1048-59. PMID 24365583 DOI: 10.1053/j.gastro.2013.12.027  0.92
2014 Patel M, Wang XX, Magomedova L, John R, Rasheed A, Santamaria H, Wang W, Tsai R, Qiu L, Orellana A, Advani A, Levi M, Cummins CL. Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice Diabetologia. 57: 435-446. PMID 24201575 DOI: 10.1007/s00125-013-3095-6  0.92
2013 Chan GNY, Patel R, Cummins CL, Bendayan R. Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells Antimicrobial Agents and Chemotherapy. 57: 4481-4488. PMID 23836171 DOI: 10.1128/AAC.00486-13  0.92
2012 Hazra S, Rasheed A, Bhatwadekar A, Wang X, Shaw LC, Patel M, Caballero S, Magomedova L, Solis N, Yan Y, Wang W, Thinschmidt JS, Verma A, Li Q, Levi M, ... Cummins CL, et al. Liver X receptor modulates diabetic retinopathy outcome in a mouse model of streptozotocin-induced diabetes. Diabetes. 61: 3270-9. PMID 22891211 DOI: 10.2337/db11-1596  0.92
2012 Wollam J, Magner DB, Magomedova L, Rass E, Shen Y, Rottiers V, Habermann B, Cummins CL, Antebi A. A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity Plos Biology. 10. PMID 22505847 DOI: 10.1371/journal.pbio.1001305  0.92
2012 Hager L, Li L, Pun H, Liu L, Hossain MA, Maguire GF, Naples M, Baker C, Magomedova L, Tam J, Adeli K, Cummins CL, Connelly PW, Ng DS. Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice. The Journal of Biological Chemistry. 287: 20755-68. PMID 22500017 DOI: 10.1074/jbc.M112.340919  0.92
2011 Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nature Chemical Biology. 7: 891-3. PMID 22057127 DOI: 10.1038/nchembio.698  0.92
2011 Wallace IM, Urbanus ML, Luciani GM, Burns AR, Han MK, Wang H, Arora K, Heisler LE, Proctor M, St Onge RP, Roemer T, Roy PJ, Cummins CL, Bader GD, Nislow C, et al. Compound prioritization methods increase rates of chemical probe discovery in model organisms. Chemistry & Biology. 18: 1273-83. PMID 22035796 DOI: 10.1016/j.chembiol.2011.07.018  0.92
2011 Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A. The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell. 10: 879-84. PMID 21749634 DOI: 10.1111/j.1474-9726.2011.00733.x  0.92
2011 Chan GN, Hoque MT, Cummins CL, Bendayan R. Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells. Journal of Neurochemistry. 118: 163-75. PMID 21517853 DOI: 10.1111/j.1471-4159.2011.07288.x  0.92
2011 Chow EC, Durk MR, Cummins CL, Pang KS. 1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo. The Journal of Pharmacology and Experimental Therapeutics. 337: 846-59. PMID 21421739 DOI: 10.1124/jpet.111.179101  0.92
2011 Patel R, Patel M, Tsai R, Lin V, Bookout AL, Zhang Y, Magomedova L, Li T, Chan JF, Budd C, Mangelsdorf DJ, Cummins CL. LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. The Journal of Clinical Investigation. 121: 431-41. PMID 21123945 DOI: 10.1172/JCI41681  0.92
2011 Schmidt DR, Schmidt S, Holmstrom SR, Makishima M, Yu RT, Cummins CL, Mangelsdorf DJ, Kliewer SA. AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids. The Journal of Biological Chemistry. 286: 2425-32. PMID 21081494 DOI: 10.1074/jbc.M110.181230  0.92
2011 Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 32: 50-7. PMID 21075140 DOI: 10.1016/j.neuro.2010.10.006  0.92
2009 Zhang Y, Chan JF, Cummins CL. Liver X Receptors as Therapeutic Targets for Managing Cholesterol: Implications for Atherosclerosis and Other Inflammatory Conditions. Clinical Lipidology. 4: 29-40. PMID 20852746 DOI: 10.2217/17584299.4.1.29  0.92
2009 Sharma KK, Wang Z, Motola DL, Cummins CL, Mangelsdorf DJ, Auchus RJ. Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Molecular Endocrinology (Baltimore, Md.). 23: 640-8. PMID 19196833 DOI: 10.1210/me.2008-0415  0.92
2008 McDonald JG, Cummins CL, Barkley RM, Thompson BM, Lincoln HA. Identification and quantitation of sorbitol-based nuclear clarifying agents extracted from common laboratory and consumer plasticware made of polypropylene. Analytical Chemistry. 80: 5532-41. PMID 18533681 DOI: 10.1021/ac8005632  0.92
2008 Lee YK, Schmidt DR, Cummins CL, Choi M, Peng L, Zhang Y, Goodwin B, Hammer RE, Mangelsdorf DJ, Kliewer SA. Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. Molecular Endocrinology (Baltimore, Md.). 22: 1345-56. PMID 18323469 DOI: 10.1210/me.2007-0565  0.92
2007 Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covey DF. Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. Journal of Medicinal Chemistry. 50: 6048-58. PMID 17963371 DOI: 10.1021/jm0707931  0.92
2007 Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, Mangelsdorf DJ. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nature Medicine. 13: 1185-92. PMID 17873880 DOI: 10.1038/nm1641  0.92
2007 Oz OK, Hajibeigi A, Howard K, Cummins CL, van Abel M, Bindels RJ, Word RA, Kuro-o M, Pak CY, Zerwekh JE. Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1893-902. PMID 17708714 DOI: 10.1359/jbmr.070808  0.92
2007 Houten SM, Volle DH, Cummins CL, Mangelsdorf DJ, Auwerx J. In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue. Molecular Endocrinology (Baltimore, Md.). 21: 1312-23. PMID 17426284 DOI: 10.1210/me.2007-0113  0.92
2007 Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, Lehrach H, Mangelsdorf DJ, Antebi A. A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 5014-9. PMID 17360327 DOI: 10.1073/pnas.0700847104  0.92
2007 Volle DH, Duggavathi R, Magnier BC, Houten SM, Cummins CL, Lobaccaro JM, Verhoeven G, Schoonjans K, Auwerx J. The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice. Genes & Development. 21: 303-15. PMID 17289919 DOI: 10.1101/gad.409307  0.92
2006 Bookout AL, Cummins CL, Mangelsdorf DJ, Pesola JM, Kramer MF. High-throughput real-time quantitative reverse transcription PCR. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 15.8. PMID 18265376 DOI: 10.1002/0471142727.mb1508s71  0.92
2006 Cummins CL, Mangelsdorf DJ. Liver X receptors and cholesterol homoeostasis: Spotlight on the adrenal gland Biochemical Society Transactions. 34: 1110-1113. PMID 17073762 DOI: 10.1042/BST0341110  0.92
2006 Cummins CL, Volle DH, Zhang Y, McDonald JG, Sion B, Lefrançois-Martinez AM, Caira F, Veyssière G, Mangelsdorf DJ, Lobaccaro JM. Liver X receptors regulate adrenal cholesterol balance. The Journal of Clinical Investigation. 116: 1902-12. PMID 16823488 DOI: 10.1172/JCI28400  0.92
2006 Rottiers V, Motola DL, Gerisch B, Cummins CL, Nishiwaki K, Mangelsdorf DJ, Antebi A. Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase. Developmental Cell. 10: 473-82. PMID 16563875 DOI: 10.1016/j.devcel.2006.02.008  0.92
2006 Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ. Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans. Cell. 124: 1209-23. PMID 16529801 DOI: 10.1016/j.cell.2006.01.037  0.92
2005 Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metabolism. 2: 217-25. PMID 16213224 DOI: 10.1016/j.cmet.2005.09.001  0.92
2004 Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. International Journal of Pharmaceutics. 277: 3-9. PMID 15158963 DOI: 10.1016/j.ijpharm.2002.12.002  0.92
2004 Volle DH, Repa JJ, Mazur A, Cummins CL, Val P, Henry-Berger J, Caira F, Veyssiere G, Mangelsdorf DJ, Lobaccaro JM. Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Molecular Endocrinology (Baltimore, Md.). 18: 888-98. PMID 14739254 DOI: 10.1210/me.2003-0338  0.92
2004 Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. The Journal of Pharmacology and Experimental Therapeutics. 308: 143-55. PMID 14569063 DOI: 10.1124/jpet.103.058065  0.92
2003 Benet LZ, Cummins CL, Wu CY. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Current Drug Metabolism. 4: 393-8. PMID 14529371 DOI: 10.2174/1389200033489389  0.92
2003 Cummins CL, Salphati L, Reid MJ, Benet LZ. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. The Journal of Pharmacology and Experimental Therapeutics. 305: 306-14. PMID 12649383 DOI: 10.1124/jpet.102.044719  0.92
2002 Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Medica. 68: 1055-8. PMID 12494328 DOI: 10.1055/s-2002-36360  0.92
2002 Cummins CL, Wu CY, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clinical Pharmacology and Therapeutics. 72: 474-89. PMID 12426511 DOI: 10.1067/mcp.2002.128388  0.92
2002 Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. The Journal of Pharmacology and Experimental Therapeutics. 300: 1036-45. PMID 11861813 DOI: 10.1124/jpet.300.3.1036  0.92
2002 Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 64: 126-34. PMID 11834888 DOI: 10.1159/000056161  0.92
2001 Cummins CL, Mangravite LM, Benet LZ. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharmaceutical Research. 18: 1102-9. PMID 11587480 DOI: 10.1023/A:1010914624111  0.92
2001 Benet LZ, Cummins CL. The drug efflux-metabolism alliance: biochemical aspects. Advanced Drug Delivery Reviews. 50: S3-11. PMID 11576692 DOI: 10.1016/S0169-409X(01)00178-8  0.92
1997 Cummins CL, O'Neil WM, Soo EC, Lloyd DK, Wainer IW. Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity Journal of Chromatography B: Biomedical Applications. 697: 283-288. PMID 9342682 DOI: 10.1016/S0378-4347(97)00084-4  0.92
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