Kenneth B. Margulies - Publications

Affiliations: 
Bioengineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biomedical Engineering

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Corbin E, Vite A, Peyster EG, Bhoopalam M, Brandimarto J, Wang X, Bennett AI, Clark AT, Cheng X, Turner KT, Musunuru K, Margulies K. Tunable and Reversible Substrate Stiffness Reveals Dynamic Mechanosensitivity of Cardiomyocytes. Acs Applied Materials & Interfaces. PMID 31074953 DOI: 10.1021/acsami.9b02446  0.8
2018 Nirschl JJ, Janowczyk A, Peyster EG, Frank R, Margulies KB, Feldman MD, Madabhushi A. A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue. Plos One. 13: e0192726. PMID 29614076 DOI: 10.1371/journal.pone.0192726  0.8
2018 Peyster EG, Madabhushi A, Margulies KB. Advanced Morphologic Analysis for Diagnosing Allograft Rejection: The Case of Cardiac Transplant Rejection. Transplantation. PMID 29570167 DOI: 10.1097/TP.0000000000002189  0.8
2017 Yeh YC, Corbin EA, Caliari SR, Ouyang L, Vega SL, Truitt R, Han L, Margulies KB, Burdick JA. Mechanically dynamic PDMS substrates to investigate changing cell environments. Biomaterials. 145: 23-32. PMID 28843064 DOI: 10.1016/j.biomaterials.2017.08.033  0.4
2016 Margulies KB. Evolving Challenges for Targeting Metabolic Abnormalities in Heart Failure. Jacc. Heart Failure. PMID 27179826 DOI: 10.1016/j.jchf.2016.03.008  1
2016 Smith JG, Felix JF, Morrison AC, Kalogeropoulos A, Trompet S, Wilk JB, Gidlöf O, Wang X, Morley M, Mendelson M, Joehanes R, Ligthart S, Shan X, Bis JC, Wang YA, ... ... Margulies KB, et al. Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure. Plos Genetics. 12: e1006034. PMID 27149122 DOI: 10.1371/journal.pgen.1006034  1
2016 Robison P, Caporizzo MA, Ahmadzadeh H, Bogush AI, Chen CY, Margulies KB, Shenoy VB, Prosser BL. Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. Science (New York, N.Y.). 352: aaf0659. PMID 27102488 DOI: 10.1126/science.aaf0659  1
2016 Dochow S, Fatakdawala H, Phipps JE, Ma D, Bocklitz T, Schmitt M, Bishop JW, Margulies KB, Marcu L, Popp J. Comparing Raman and fluorescence lifetime spectroscopy from human atherosclerotic lesions using a bimodal probe. Journal of Biophotonics. PMID 27003796 DOI: 10.1002/jbio.201500341  1
2016 Birati EY, Mathelier H, Molina M, Hanff TC, Mazurek JA, Atluri P, Acker MA, Rame JE, Margulies KB, Goldberg LR, Jessup M. Comparison of Causes of Death After Heart Transplantation in Patients With Left Ventricular Ejection Fractions ≤35% Versus >35. The American Journal of Cardiology. PMID 26899490 DOI: 10.1016/j.amjcard.2016.01.028  1
2015 Das A, Morley M, Moravec CS, Tang WH, Hakonarson H, Margulies KB, Cappola TP, Jensen S, Hannenhalli S. Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability. Nature Communications. 6: 8555. PMID 26456756 DOI: 10.1038/ncomms9555  1
2015 Borlaug BA, Chen H, Lin G, Redfield MM, Lewis GD, Semigran MJ, McNulty SE, LeWinter M, Deswal A, Margulies KB. Response to Letter Regarding Article, “Effects of Sildenafil on Ventricular and Vascular Function in Heart Failure With Preserved Ejection Fraction”. Circulation. Heart Failure. 8: 840. PMID 26405727  1
2015 Grodin JL, Stevens SR, Lisa LF, Kiernan M, Birati EY, Gupta D, Bart BA, Felker GM, Chen HH, Butler J, Dávila-Román VG, Margulies KB, Hernandez AF, Anstrom KJ, Tang WH. Intensification of Medication Therapy for Cardiorenal Syndrome in Acute Decompensated Heart Failure. Journal of Cardiac Failure. PMID 26209004 DOI: 10.1016/j.cardfail.2015.07.007  1
2015 Jia C, Guan W, Yang A, Xiao R, Tang WH, Moravec CS, Margulies KB, Cappola TP, Li M, Li C. MetaDiff: differential isoform expression analysis using random-effects meta-regression. Bmc Bioinformatics. 16: 208. PMID 26134005 DOI: 10.1186/s12859-015-0623-z  1
2015 Givertz MM, Anstrom KJ, Redfield MM, Deswal A, Haddad H, Butler J, Tang WH, Dunlap ME, LeWinter MM, Mann DL, Felker GM, O'Connor CM, Goldsmith SR, Ofili EO, Saltzberg MT, ... Margulies KB, et al. Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. Circulation. 131: 1763-71. PMID 25986447 DOI: 10.1161/CIRCULATIONAHA.114.014536  1
2015 Fatakdawala H, Gorpas D, Bishop JW, Bec J, Ma D, Southard JA, Margulies KB, Marcu L. Fluorescence Lifetime Imaging Combined with Conventional Intravascular Ultrasound for Enhanced Assessment of Atherosclerotic Plaques: an Ex Vivo Study in Human Coronary Arteries. Journal of Cardiovascular Translational Research. 8: 253-63. PMID 25931307 DOI: 10.1007/s12265-015-9627-3  1
2015 Herren AW, Weber DM, Rigor RR, Margulies KB, Phinney BS, Bers DM. CaMKII Phosphorylation of NaV1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure. Journal of Proteome Research. 14: 2298-311. PMID 25815641 DOI: 10.1021/acs.jproteome.5b00107  1
2015 Borlaug BA, Lewis GD, McNulty SE, Semigran MJ, LeWinter M, Chen H, Lin G, Deswal A, Margulies KB, Redfield MM. Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction. Circulation. Heart Failure. 8: 533-41. PMID 25782985 DOI: 10.1161/CIRCHEARTFAILURE.114.001915  1
2015 Birati EY, Quiaoit Y, Wald J, Kirkpatrick JN, Goldberg LR, Atluri P, Margulies KB, Eduardo Rame J. Ventricular assist device thrombosis: A wide spectrum of clinical presentation. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 34: 613-5. PMID 25703960 DOI: 10.1016/j.healun.2014.12.007  1
2015 Zamani P, Rawat D, Shiva-Kumar P, Geraci S, Bhuva R, Konda P, Doulias PT, Ischiropoulos H, Townsend RR, Margulies KB, Cappola TP, Poole DC, Chirinos JA. Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction. Circulation. 131: 371-80; discussion 3. PMID 25533966 DOI: 10.1161/CIRCULATIONAHA.114.012957  1
2015 Liu Y, Morley M, Brandimarto J, Hannenhalli S, Hu Y, Ashley EA, Tang WH, Moravec CS, Margulies KB, Cappola TP, Li M. RNA-Seq identifies novel myocardial gene expression signatures of heart failure. Genomics. 105: 83-9. PMID 25528681 DOI: 10.1016/j.ygeno.2014.12.002  1
2015 Borlaug BA, Chen H, Lin G, Redfield MM, Lewis GD, Semigran MJ, McNulty SE, LeWinter M, Deswal A, Margulies KB. Response to letter regarding article, Effects of Sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction Circulation: Heart Failure. 8: 840. DOI: 10.1161/CIRCHEARTFAILURE.115.002372  1
2014 Fargnoli AS, Katz MG, Williams RD, Margulies KB, Bridges CR. A needleless liquid jet injection delivery method for cardiac gene therapy: a comparative evaluation versus standard routes of delivery reveals enhanced therapeutic retention and cardiac specific gene expression. Journal of Cardiovascular Translational Research. 7: 756-67. PMID 25315468 DOI: 10.1007/s12265-014-9593-1  1
2014 Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. Journal of the American Heart Association. 3. PMID 25146704 DOI: 10.1161/JAHA.114.001015  1
2014 Alvarez RM, Margulies KB. Epigenetic memory and cardiac cell therapy. Journal of the American College of Cardiology. 64: 449-50. PMID 25082576 DOI: 10.1016/j.jacc.2014.05.021  1
2014 Margulies KB, Anstrom KJ, Hernandez AF, Redfield MM, Shah MR, Braunwald E, Cappola TP. GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study. Circulation. Heart Failure. 7: 673-9. PMID 25028349 DOI: 10.1161/CIRCHEARTFAILURE.114.000346  1
2014 Fargnoli AS, Mu A, Katz MG, Williams RD, Margulies KB, Weiner DB, Yang S, Bridges CR. Anti-inflammatory loaded poly-lactic glycolic acid nanoparticle formulations to enhance myocardial gene transfer: an in-vitro assessment of a drug/gene combination therapeutic approach for direct injection. Journal of Translational Medicine. 12: 171. PMID 24934216 DOI: 10.1186/1479-5876-12-171  1
2014 Cohen JE, Purcell BP, MacArthur JW, Mu A, Shudo Y, Patel JB, Brusalis CM, Trubelja A, Fairman AS, Edwards BB, Davis MS, Hung G, Hiesinger W, Atluri P, Margulies KB, et al. A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy. Circulation. Heart Failure. 7: 619-26. PMID 24902740 DOI: 10.1161/CIRCHEARTFAILURE.113.001273  1
2014 Birati EY, Kirkpatrick JN, Rame JE, Bala R, Margulies KB. Dynamic left ventricular assist device inflow obstruction. Circulation. Heart Failure. 7: 225-6. PMID 24449814 DOI: 10.1161/CIRCHEARTFAILURE.113.000941  1
2014 Lin H, Dolmatova EV, Morley MP, Lunetta KL, McManus DD, Magnani JW, Margulies KB, Hakonarson H, del Monte F, Benjamin EJ, Cappola TP, Ellinor PT. Gene expression and genetic variation in human atria. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 11: 266-71. PMID 24177373 DOI: 10.1016/j.hrthm.2013.10.051  1
2013 Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, ... ... Margulies KB, et al. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. Jama. 310: 2533-43. PMID 24247300 DOI: 10.1001/jama.2013.282190  1
2013 Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM. BET bromodomains mediate transcriptional pause release in heart failure Cell. 154: 569-582. PMID 23911322 DOI: 10.1016/j.cell.2013.07.013  1
2013 Ahuja P, Wanagat J, Wang Z, Wang Y, Liem DA, Ping P, Antoshechkin IA, Margulies KB, Maclellan WR. Divergent mitochondrial biogenesis responses in human cardiomyopathy. Circulation. 127: 1957-67. PMID 23589024 DOI: 10.1161/CIRCULATIONAHA.112.001219  1
2013 Pedrotty DM, Rame JE, Margulies KB. Management of ventricular arrhythmias in patients with ventricular assist devices. Current Opinion in Cardiology. 28: 360-8. PMID 23549232 DOI: 10.1097/HCO.0b013e32835fb7dc  1
2012 Elser JA, Margulies KB. Hybrid Mathematical Model of Cardiomyocyte Turnover in the Adult Human Heart Plos One. 7. PMID 23284740 DOI: 10.1371/journal.pone.0051683  1
2012 Purcell BP, Elser JA, Mu A, Margulies KB, Burdick JA. Synergistic effects of SDF-1α chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium. Biomaterials. 33: 7849-57. PMID 22835643 DOI: 10.1016/j.biomaterials.2012.07.005  1
2012 Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ, Koch W. Animal models of heart failure: a scientific statement from the American Heart Association. Circulation Research. 111: 131-50. PMID 22595296 DOI: 10.1161/RES.0b013e3182582523  1
2012 Despa S, Margulies KB, Chen L, Knowlton AA, Havel PJ, Taegtmeyer H, Bers DM, Despa F. Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats. Circulation Research. 110: 598-608. PMID 22275486 DOI: 10.1161/CIRCRESAHA.111.258285  1
2012 Shan X, Quaile MP, Monk JK, French B, Cappola TP, Margulies KB. Differential expression of PDE5 in failing and nonfailing human myocardium. Circulation. Heart Failure. 5: 79-86. PMID 22135403 DOI: 10.1161/CIRCHEARTFAILURE.111.961706  1
2012 Dickey DM, Dries DL, Margulies KB, Potter LR. Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte. Journal of Molecular and Cellular Cardiology. 52: 727-32. PMID 22133375 DOI: 10.1016/j.yjmcc.2011.11.007  1
2012 Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Engineering. Part A. 18: 910-9. PMID 22092279 DOI: 10.1089/ten.TEA.2011.0341  1
2012 Elser JA, Purcell BP, Allana IA, Burdick JA, Margulies KB. Ischemia induces P-selectin-mediated selective progenitor cell engraftment in the isolated-perfused heart. Journal of Molecular and Cellular Cardiology. 52: 105-12. PMID 22047808 DOI: 10.1016/j.yjmcc.2011.10.009  1
2012 Hellawell JL, Margulies KB. Myocardial reverse remodeling. Cardiovascular Therapeutics. 30: 172-81. PMID 21108773 DOI: 10.1111/j.1755-5922.2010.00247.x  1
2011 Margulies KB, Rame JE. Adaptations to pulsatile versus nonpulsatile ventricular assist device support. Circulation. Heart Failure. 4: 535-7. PMID 21934088 DOI: 10.1161/CIRCHEARTFAILURE.111.963777  1
2011 Belmonte SL, Margulies KB, Blaxall BC. S100A1: Another Step Toward Therapeutic Development for Heart Failure. Journal of the American College of Cardiology. 58: 974-6. PMID 21851888 DOI: 10.1016/j.jacc.2011.04.032  1
2011 Barth AS, Kumordzie A, Frangakis C, Margulies KB, Cappola TP, Tomaselli GF. Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circulation. Cardiovascular Genetics. 4: 475-83. PMID 21828333 DOI: 10.1161/CIRCGENETICS.110.957571  1
2011 Cappola TP, Margulies KB. Functional genomics applied to cardiovascular medicine. Circulation. 124: 87-94. PMID 21730321 DOI: 10.1161/CIRCULATIONAHA.111.027300  1
2011 Shan X, Margulies KB. Differential regulation of PDE5 expression in left and right ventricles of feline hypertrophy models. Plos One. 6: e19922. PMID 21625548 DOI: 10.1371/journal.pone.0019922  1
2011 Norman HS, Oujiri J, Larue SJ, Chapman CB, Margulies KB, Sweitzer NK. Decreased cardiac functional reserve in heart failure with preserved systolic function. Journal of Cardiac Failure. 17: 301-8. PMID 21440868 DOI: 10.1016/j.cardfail.2010.11.004  1
2011 Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Homeodomain only protein x is down-regulated in human heart failure. Journal of Molecular and Cellular Cardiology. 50: 1056-8. PMID 21382376 DOI: 10.1016/j.yjmcc.2011.02.015  1
2011 Dean AS, Libonati JR, Madonna D, Ratcliffe SJ, Margulies KB. Resistance training improves vasoreactivity in end-stage heart failure patients on inotropic support. The Journal of Cardiovascular Nursing. 26: 218-23. PMID 21263349 DOI: 10.1097/JCN.0b013e3181f29a46  1
2011 Lee CS, Moser DK, Lennie TA, Tkacs NC, Margulies KB, Riegel B. Biomarkers of myocardial stress and systemic inflammation in patients who engage in heart failure self-care management. The Journal of Cardiovascular Nursing. 26: 321-8. PMID 21263344 DOI: 10.1097/JCN.0b013e31820344be  1
2011 Guo D, Lian J, Liu T, Cox R, Margulies KB, Kowey PR, Yan GX. Contribution of late sodium current (I(Na-L)) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 8: 762-9. PMID 21184845 DOI: 10.1016/j.hrthm.2010.12.026  1
2011 Methvin AB, Owens AT, Emmi AG, Allen M, Wiegers SE, Dries DL, Margulies KB, Forfia PR. Ventilatory inefficiency reflects right ventricular dysfunction in systolic heart failure. Chest. 139: 617-25. PMID 20688926 DOI: 10.1378/chest.10-0318  1
2011 Margulies KB, Houser SR. Cellular Basis for Heart Failure Heart Failure. 32-47. DOI: 10.1016/B978-1-4160-5895-3.10003-8  1
2010 Glessner JT, Reilly MP, Kim CE, Takahashi N, Albano A, Hou C, Bradfield JP, Zhang H, Sleiman PM, Flory JH, Imielinski M, Frackelton EC, Chiavacci R, Thomas KA, Garris M, ... ... Margulies KB, et al. Strong synaptic transmission impact by copy number variations in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 107: 10584-9. PMID 20489179 DOI: 10.1073/pnas.1000274107  1
2010 Codina M, Elser J, Margulies KB. Current status of stem cell therapy in heart failure Current Cardiology Reports. 12: 199-208. PMID 20424962 DOI: 10.1007/s11886-010-0098-5  1
2010 Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, et al. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Science Translational Medicine. 2: 26ra26. PMID 20375365 DOI: 10.1126/scitranslmed.3000502  1
2010 Barth AS, Kumordzie A, Colantuoni C, Margulies KB, Cappola TP, Tomaselli GF. Reciprocal regulation of metabolic and signaling pathways. Bmc Genomics. 11: 197. PMID 20334672 DOI: 10.1186/1471-2164-11-197  1
2009 Putt ME, Hannenhalli S, Lu Y, Haines P, Chandrupatla HR, Morrisey EE, Margulies KB, Cappola TP. Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure. Circulation. Cardiovascular Genetics. 2: 212-9. PMID 20031589 DOI: 10.1161/CIRCGENETICS.108.816686  1
2009 Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, ... Margulies KB, et al. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. The Journal of Clinical Investigation. 119: 3420-36. PMID 19855129 DOI: 10.1172/JCI39109  1
2009 Quaile MP, Kubo H, Kimbrough CL, Douglas SA, Margulies KB. Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium. Circulation. Heart Failure. 2: 39-46. PMID 19808314 DOI: 10.1161/CIRCHEARTFAILURE.107.748343  1
2009 Margulies KB. MicroRNAs as novel myocardial biomarkers. Clinical Chemistry. 55: 1897-9. PMID 19696114 DOI: 10.1373/clinchem.2009.131649  1
2009 Margulies KB, Bednarik DP, Dries DL. Genomics, transcriptional profiling, and heart failure. Journal of the American College of Cardiology. 53: 1752-9. PMID 19422981 DOI: 10.1016/j.jacc.2008.12.064  1
2009 Matkovich SJ, Van Booven DJ, Youker KA, Torre-Amione G, Diwan A, Eschenbacher WH, Dorn LE, Watson MA, Margulies KB, Dorn GW. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation. 119: 1263-71. PMID 19237659 DOI: 10.1161/CIRCULATIONAHA.108.813576  1
2008 Fermin DR, Barac A, Lee S, Polster SP, Hannenhalli S, Bergemann TL, Grindle S, Dyke DB, Pagani F, Miller LW, Tan S, Dos Remedios C, Cappola TP, Margulies KB, Hall JL. Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure. Circulation. Cardiovascular Genetics. 1: 117-25. PMID 20031553 DOI: 10.1161/CIRCGENETICS.108.802652  1
2008 Shan X, Wang H, Margulies KB. Apoptosis signal-regulating kinase 1 attenuates atrial natriuretic peptide secretion. Biochemistry. 47: 10041-8. PMID 18759454 DOI: 10.1021/bi800972z  1
2008 Kubo H, Jaleel N, Kumarapeli A, Berretta RM, Bratinov G, Shan X, Wang H, Houser SR, Margulies KB. Increased cardiac myocyte progenitors in failing human hearts. Circulation. 118: 649-57. PMID 18645055 DOI: 10.1161/CIRCULATIONAHA.107.761031  1
2008 Mays TA, Binkley PF, Lesinski A, Doshi AA, Quaile MP, Margulies KB, Janssen PM, Rafael-Fortney JA. Claudin-5 levels are reduced in human end-stage cardiomyopathy. Journal of Molecular and Cellular Cardiology. 45: 81-7. PMID 18513742 DOI: 10.1016/j.yjmcc.2008.04.005  1
2008 Chen X, Zhang X, Harris DM, Piacentino V, Berretta RM, Margulies KB, Houser SR. Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation. American Journal of Physiology. Heart and Circulatory Physiology. 294: H2257-67. PMID 18359894 DOI: 10.1152/ajpheart.01335.2007  1
2007 Quaile MP, Rossman EI, Berretta RM, Bratinov G, Kubo H, Houser SR, Margulies KB. Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload. Journal of Molecular and Cellular Cardiology. 43: 552-63. PMID 17931654 DOI: 10.1016/j.yjmcc.2007.08.013  1
2007 Li J, Wei H, Chesley A, Moon C, Krawczyk M, Volkova M, Ziman B, Margulies KB, Talan M, Crow MT, Boheler KR. The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity. The Journal of Biological Chemistry. 282: 34984-93. PMID 17925408 DOI: 10.1074/jbc.M703513200  1
2007 McGinley JC, Berretta RM, Chaudhary K, Rossman E, Bratinov GD, Gaughan JP, Houser S, Margulies KB. Impaired contractile reserve in severe mitral valve regurgitation with a preserved ejection fraction. European Journal of Heart Failure. 9: 857-64. PMID 17594913 DOI: 10.1016/j.ejheart.2007.05.013  1
2007 Pfister R, Acksteiner C, Baumgarth J, Burst V, Geissler HJ, Margulies KB, Houser S, Bloch W, Flesch M. Loss of beta1D-integrin function in human ischemic cardiomyopathy. Basic Research in Cardiology. 102: 257-64. PMID 17186162 DOI: 10.1007/s00395-006-0640-1  1
2007 Petre RE, Quaile MP, Rossman EI, Ratcliffe SJ, Bailey BA, Houser SR, Margulies KB. Sex-based differences in myocardial contractile reserve. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292: R810-8. PMID 17008460 DOI: 10.1152/ajpregu.00377.2006  1
2007 Boateng SY, Belin RJ, Geenen DL, Margulies KB, Martin JL, Hoshijima M, de Tombe PP, Russell B. Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein. American Journal of Physiology. Heart and Circulatory Physiology. 292: H259-69. PMID 16963613 DOI: 10.1152/ajpheart.00766.2006  1
2006 Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP. Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation. 114: 1269-76. PMID 16952980 DOI: 10.1161/CIRCULATIONAHA.106.632430  1
2006 Margulies KB. Restoration of beta1 adrenergic receptor density. Journal of Molecular and Cellular Cardiology. 41: 413-5. PMID 16876191 DOI: 10.1016/j.yjmcc.2006.06.069  1
2006 Margulies KB, Burnett JC. Visualizing the basis for paracrine natriuretic peptide signaling in human heart. Circulation Research. 99: 113-5. PMID 16857970 DOI: 10.1161/01.RES.0000234911.22854.d9  1
2006 Grzywacz FW, Piacentino V, Marble J, Bozorgnia B, Gaughan JP, Rothman SA, Margulies KB. Effect of acute unloading via head-up tilt on QTc prolongation in patients with ischemic or non-ischemic cardiomyopathy. The American Journal of Cardiology. 97: 412-5. PMID 16442407 DOI: 10.1016/j.amjcard.2005.08.064  1
2006 Jung AS, Kubo H, Wilson R, Houser SR, Margulies KB. Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1756-62. PMID 16327014 DOI: 10.1152/ajpheart.01104.2005  1
2005 Petre RE, Quaile MP, Wendt K, Houser SR, Wald J, Goldman BI, Margulies KB. Regionally heterogeneous tissue mechanics in cardiac amyloidosis. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 12: 246-50. PMID 16399650 DOI: 10.1080/13506120500386824  1
2005 Iaccarino G, Barbato E, Cipolletta E, De Amicis V, Margulies KB, Leosco D, Trimarco B, Koch WJ. Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure. European Heart Journal. 26: 1752-8. PMID 16055494 DOI: 10.1093/eurheartj/ehi429  1
2005 Dean AS, Margulies KB, Nicholas JJ, Rubin S, Gaughan JP, Libonati JR. Impaired vasoreactivity in end-stage heart failure patients on intravenous inotropic support. Journal of Cardiac Failure. 11: 351-7. PMID 15948085 DOI: 10.1016/j.cardfail.2004.12.002  1
2005 McGinley JC, Berretta RM, Bratinov GD, Dhar S, Gaughan JP, Margulies KB. Subvalvular alterations promote increased mitral valve regurgitation in progressive dilated cardiomyopathy. Journal of Cardiac Failure. 11: 343-50. PMID 15948084 DOI: 10.1016/j.cardfail.2004.12.003  1
2005 Harding JD, Piacentino V, Rothman S, Chambers S, Jessup M, Margulies KB. Prolonged repolarization after ventricular assist device support is associated with arrhythmias in humans with congestive heart failure. Journal of Cardiac Failure. 11: 227-32. PMID 15812752 DOI: 10.1016/j.cardfail.2004.08.158  1
2005 Margulies KB, Matiwala S, Cornejo C, Olsen H, Craven WA, Bednarik D. Mixed messages: transcription patterns in failing and recovering human myocardium. Circulation Research. 96: 592-9. PMID 15718504 DOI: 10.1161/01.RES.0000159390.03503.c3  1
2005 Jung AS, Quaile MP, Mills GD, Bednarik DP, Houser SR, Margulies KB. Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacophore, on myocyte calcium cycling and contractility. The Journal of Pharmacology and Experimental Therapeutics. 312: 517-24. PMID 15550574 DOI: 10.1124/jpet.104.075895  1
2004 Matiwala S, Margulies KB. Mechanical approaches to alter remodeling. Current Heart Failure Reports. 1: 14-8. PMID 16036020  1
2004 Chaudhary KW, Rossman EI, Piacentino V, Kenessey A, Weber C, Gaughan JP, Ojamaa K, Klein I, Bers DM, Houser SR, Margulies KB. Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart. Journal of the American College of Cardiology. 44: 837-45. PMID 15312868 DOI: 10.1016/j.jacc.2004.05.049  1
2004 Rossman EI, Petre RE, Chaudhary KW, Piacentino V, Janssen PM, Gaughan JP, Houser SR, Margulies KB. Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium. Journal of Molecular and Cellular Cardiology. 36: 33-42. PMID 14734045 DOI: 10.1016/j.yjmcc.2003.09.001  1
2003 Margulies KB. Blocking stretch-induced myocardial remodeling. Circulation Research. 93: 1020-2. PMID 14645132 DOI: 10.1161/01.RES.0000105922.61310.D4  1
2003 Fedalen PA, Piacentino V, Jeevanandam V, Fisher C, Greene J, Margulies KB, Houser SR, Furukawa S, Singhal AK, Goldman BI. Pharmacologic pre-conditioning and controlled reperfusion prevent ischemia-reperfusion injury after 30 minutes of hypoxia/ischemia in porcine hearts. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 22: 1234-44. PMID 14585385 DOI: 10.1016/S1053-2498(02)01237-8  1
2003 Kashem A, Kashem S, Santamore WP, Crabbe DL, Margulies KB, Melvin DB, Goldman BI. Early and late results of left ventricular reshaping by passive cardiac-support device in canine heart failure. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 22: 1046-53. PMID 12957615 DOI: 10.1016/S1053-2498(02)01162-2  1
2003 Kashem A, Santamore WP, Hassan S, Melvin DB, Crabbe DL, Margulies KB, Goldman BI, Llort F, Krieger C, Lesniak J. CardioClasp changes left ventricular shape acutely in enlarged canine heart. Journal of Cardiac Surgery. 18: S49-60. PMID 12930271 DOI: 10.1046/j.1540-8191.18.s2.5.x  1
2003 Houser SR, Margulies KB. Is depressed myocyte contractility centrally involved in heart failure? Circulation Research. 92: 350-8. PMID 12623873 DOI: 10.1161/01.RES.0000060027.40275.A6  1
2003 Piacentino V, Weber CR, Chen X, Weisser-Thomas J, Margulies KB, Bers DM, Houser SR. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circulation Research. 92: 651-8. PMID 12600875 DOI: 10.1161/01.RES.0000062469.83985.9B  1
2003 McGowan BS, Scott CB, Mu A, McCormick RJ, Thomas DP, Margulies KB. Unloading-induced remodeling in the normal and hypertrophic left ventricle. American Journal of Physiology. Heart and Circulatory Physiology. 284: H2061-8. PMID 12573997 DOI: 10.1152/ajpheart.00873.2002  1
2003 Crabbe DL, Dipla K, Ambati S, Zafeiridis A, Gaughan JP, Houser SR, Margulies KB. Gender differences in post-infarction hypertrophy in end-stage failing hearts. Journal of the American College of Cardiology. 41: 300-6. PMID 12535826 DOI: 10.1016/S0735-1097(02)02710-9  1
2003 Zhao F, Chen JSJ, Blagg AG, Margulies KB. Global stress-strain relationship of a beating heart American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 55: 91-92. DOI: 10.1115/IMECE2003-41156  1
2003 Zhao F, Chen JSJ, Blagg AG, Berretta R, Margulies KB. An integrated method to determine the stress-strain relationship of beating heart Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2003: 273-274. DOI: 10.1109/NEBC.2003.1216100  1
2003 Zhao F, Chen JSJ, Blagg AG, Berretta R, Margulies KB. An integrated method to determine stress-strain relationship of beating heart Bioengineering, Proceedings of the Northeast Conference. 273-274.  1
2002 Margulies KB. Reversal mechanisms of left ventricular remodeling: lessons from left ventricular assist device experiments. Journal of Cardiac Failure. 8: S500-5. PMID 12555165 DOI: 10.1054/jcaf.2002.129264  1
2002 Weber CR, Piacentino V, Margulies KB, Bers DM, Houser SR. Calcium influx via I(NCX) is favored in failing human ventricular myocytes. Annals of the New York Academy of Sciences. 976: 478-9. PMID 12502599  1
2002 Kashem A, Santamore WP, Hassan S, Crabbe DL, Margulies KB, Melvin DB. CardioClasp: A new passive device to reshape cardiac enlargement Asaio Journal. 48: 253-259. PMID 12058999  1
2001 Flesch M, Margulies KB, Mochmann HC, Engel D, Sivasubramanian N, Mann DL. Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading. Circulation. 104: 2273-6. PMID 11696464  1
2001 Harding JD, Piacentino V, Gaughan JP, Houser SR, Margulies KB. Electrophysiological alterations after mechanical circulatory support in patients with advanced cardiac failure. Circulation. 104: 1241-7. PMID 11551874  1
2001 Kubo H, Margulies KB, Piacentino V, Gaughan JP, Houser SR. Patients with end-stage congestive heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance. Circulation. 104: 1012-8. PMID 11524394  1
2001 Welsh DC, Dipla K, McNulty PH, Mu A, Ojamaa KM, Klein I, Houser SR, Margulies KB. Preserved contractile function despite atrophic remodeling in unloaded rat hearts American Journal of Physiology - Heart and Circulatory Physiology. 281. PMID 11514279  1
2000 Margulies KB. Ventricular unloading and myocyte recovery: Insight gained into the pathophysiology of congestive heart failure Current Cardiology Reports. 2: 181-188. PMID 10980891 DOI: 10.1007/s11886-000-0067-5  1
1999 Soloff LA, Margulies KB, Dipla K, Mattiello JA, Houser SR, Jeevanandam V. Atrophy of myocardium and its myocytes by left ventricular assist device [3] (multiple letters) Circulation. 100: 1012. PMID 10469428  1
1999 Gaughan JP, Furukawa S, Jeevanandam V, Hefner CA, Kubo H, Margulies KB, McGowan BS, Mattiello JA, Dipla K, Piacentino V, Li S, Houser SR. Sodium/calcium exchange contributes to contraction and relaxation in failed human ventricular myocytes. The American Journal of Physiology. 277: H714-24. PMID 10444498  1
1999 Margulies KB, Jaffer S, Pollack PS, Ennis KJ. Physiological significance of early deceleration time prolongation in asymptomatic elderly subjects. Journal of Cardiac Failure. 5: 92-9. PMID 10404348 DOI: 10.1016/S1071-9164(99)90031-3  1
1999 Dipla K, Mattiello JA, Margulies KB, Jeevanandam V, Houser SR. The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes. Circulation Research. 84: 435-44. PMID 10066678  1
1998 Zafeiridis A, Jeevanandam V, Houser SR, Margulies KB. Regression of cellular hypertrophy after left ventricular assist device support Circulation. 98: 656-662. PMID 9715858  1
1998 Dipla K, Mattiello JA, Jeevanandam V, Houser SR, Margulies KB. Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure. Circulation. 97: 2316-22. PMID 9639375  1
1997 Altemose GT, Gritsus V, Jeevanandam V, Goldman B, Margulies KB. Altered myocardial phenotype after mechanical support in human beings with advanced cardiomyopathy Journal of Heart and Lung Transplantation. 16: 765-773. PMID 9257259  1
1997 Crabbe DL, Pollack PS, Zhang XY, Margulies KB. Color M-mode Doppler indicates early diastolic dysfunction in evolving dilated cardiomyopathy Journal of the American Society of Echocardiography. 10: 425.  1
1997 Dipla K, Mattiello J, Jeevanandam V, Margulies KB, Houser SR. Left ventricular support of the failing human heart produces improved myocyte contractility Faseb Journal. 11.  1
1996 Leech SH, Mather PJ, Eisen HJ, Pina IL, Margulies KB, Bove AA, Jeevanandam V. Donor-specific HLA antibodies after transplantation are associated with deterioration in cardiac function. Clinical Transplantation. 10: 639-45. PMID 8996758  1
1995 Clavell AL, Stingo AJ, Margulies KB, Brandt RR, Burnett JC. Role of endothelin receptor subtypes in the in vivo regulation of renal function American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 268. PMID 7900845  1
1995 Margulies KB, Barclay PL, Burnett JC. The role of neutral endopeptidase in dogs with evolving congestive heart failure. Circulation. 91: 2036-42. PMID 7895362  1
1995 Mather PJ, Jeevanandam V, Eisen HJ, Piña IL, Margulies KB, McClurken J, Furakawa S, Bove AA. Functional and morphologic adaptation of undersized donor hearts after heart transplantation. Journal of the American College of Cardiology. 26: 737-42. PMID 7642868 DOI: 10.1016/0735-1097(95)00216-Q  1
1994 Margulies KB, Burnett JC. Inhibition of cyclic GMP phosphodiesterases augments renal responses to atrial natriuretic factor in congestive heart failure Journal of Cardiac Failure. 1: 71-80. PMID 9420635 DOI: 10.1016/1071-9164(94)90010-8  1
1993 Margulies KB, Burnett JC. Neutral endopeptidase 24.11: A modulator of natriuretic peptides Seminars in Nephrology. 13: 71-77. PMID 8434188  1
1992 Bennett T, Gardiner SM, Perrella MA, Margulies KB, Burnett JC. Role of nitric oxide in the control of basal hemodynamics [3] American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 262. PMID 1566940  1
1991 Perrella MA, Hildebrand FL, Margulies KB, Burnett JC. Endothelium-derived relaxing factor in regulation of basal cardiopulmonary and renal function American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 261. PMID 1877690  1
1991 Perrella MA, Margulies KB, Wei CM, Aarhus LL, Heublein DM, Burnett JC. Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs Journal of Clinical Investigation. 87: 1649-1655. PMID 1850758  1
1991 Margulies KB, Heublein DM, Perrella MA, Burnett JG. ANF-mediated renal cGMP generation in congestive heart failure American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 260. PMID 1849364  1
1991 Perrella MA, Margulies KB, Burnett JC. Pathophysiology of congestive heart failure: Role of atrial natriuretic factor and therapeutic implications Canadian Journal of Physiology and Pharmacology. 69: 1576-1581. PMID 1838025  1
1991 Margulies KB, Hildebrand FL, Heublein DM, Burnett JC. Radiocontrast increases plasma and urinary endothelin Journal of the American Society of Nephrology. 2: 1041-1045. PMID 1836965  1
1991 Margulies KB, Perrella MA, McKinley LJ, Burnett JC. Angiotensin inhibition potentiates the renal responses to neutral endopeptidase inhibition in dogs with congestive heart failure Journal of Clinical Investigation. 88: 1636-1642. PMID 1658047  1
1990 Margulies KB, Hildebrand FL, Lerman A, Perrella MA, Burnett JC. Increased endothelin in experimental heart failure Circulation. 82: 2226-2230. PMID 2242543  1
1990 Lerman A, Hildebrand FL, Margulies KB, O'Murchu B, Perrella MA, Heublein DM, Schwab TR, Burnett JC. Endothelin: A new cardiovascular regulatory peptide Mayo Clinic Proceedings. 65: 1441-1455. PMID 2232899  1
1990 Cavero PG, Miller WL, Heublein DM, Margulies KB, Burnett JC. Endothelin in experimental congestive heart failure in the anesthetized dog American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 259. PMID 2201206  1
1990 Margulies KB, McKinley LJ, Cavero PG, Burnett JC. Induction and prevention of radiocontrast-induced nephropathy in dogs with heart failure Kidney International. 38: 1101-1108. PMID 2150085  1
1990 Margulies KB, Cavero PG, Seymour AA, Delaney NG, Burnett JC. Neutral endopeptidase inhibition potentiates the renal actions of atrial natriuretic factor. Kidney International. 38: 67-72. PMID 2143548  1
1990 Margulies KB, Burnett JC. Atrial natriuretic factor modulates whole kidney tubuloglomerular feedback American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 259. PMID 2142863  1
1990 Cavero PG, Margulies KB, Winaver J, Seymour AA, Delaney NG, Burnett JC. Cardiorenal actions of neutral endopeptidase inhibition in experimental congestive heart failure. Circulation. 82: 196-201. PMID 2142023  1
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