Alan Wells - Publications

Bioengineering University of Pittsburgh, Pittsburgh, PA, United States 
Biomedical Engineering, Bioinformatics Biology, General Biophysics, Oncology

126 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ma B, Wells A, Clark AM. The pan-therapeutic resistance of disseminated tumor cells: role of phenotypic plasticity and the metastatic microenvironment. Seminars in Cancer Biology. PMID 31376430 DOI: 10.1016/j.semcancer.2019.07.021  0.48
2019 Jiang Y, Wells A, Sylakowski K, Clark AM, Ma B. Adult Stem Cell Functioning in the Tumor Micro-Environment. International Journal of Molecular Sciences. 20. PMID 31130595 DOI: 10.3390/ijms20102566  0.88
2018 Wells A, Clark A, Bradshaw A, Ma B, Edington H. The great escape: How metastases of melanoma, and other carcinomas, avoid elimination. Experimental Biology and Medicine (Maywood, N.J.). 243: 1245-1255. PMID 30764707 DOI: 10.1177/1535370218820287  0.48
2018 Beckwitt CH, Clark AM, Ma B, Whaley D, Oltvai ZN, Wells A. Statins attenuate outgrowth of breast cancer metastases. British Journal of Cancer. 119: 1094-1105. PMID 30401978 DOI: 10.1038/s41416-018-0267-7  0.6
2018 Bradshaw A, Sylakowski K, Wells A. The Pro-reparative Engine: Stem Cells Aid Healing by Dampening Inflammation. Current Pathobiology Reports. 6: 109-115. PMID 30271682 DOI: 10.1007/s40139-018-0167-9  0.88
2018 Clark AM, Kumar M, Wheeler S, Young C, Venkataramanan R, Stolz D, Griffith L, Lauffenburger DA, Wells A. A model of dormant-emergent metastatic breast cancer progression enabling exploration of biomarker signatures. Molecular & Cellular Proteomics : McP. PMID 29353230 DOI: 10.1074/mcp.RA117.000370  0.84
2017 Beckwitt CH, Clark AM, Wheeler S, Taylor DL, Stolz DB, Griffith L, Wells A. Liver 'organ on a chip'. Experimental Cell Research. PMID 29291400 DOI: 10.1016/j.yexcr.2017.12.023  0.84
2017 Shao H, Wang A, Lauffenburger D, Wells A. Tyro3-mediated phosphorylation of ACTN4 at tyrosines is FAK-dependent and decreases susceptibility to cleavage by m-Calpain. The International Journal of Biochemistry & Cell Biology. PMID 29274473 DOI: 10.1016/j.biocel.2017.12.014  0.48
2017 Dioufa N, Clark AM, Ma B, Beckwitt CH, Wells A. Bi-directional exosome-driven intercommunication between the hepatic niche and cancer cells. Molecular Cancer. 16: 172. PMID 29137633 DOI: 10.1186/s12943-017-0740-6  0.48
2017 Kader M, El-Azher M, Vorhauer J, Kode BB, Wells JZ, Stolz D, Michalopoulos G, Wells A, Scott M, Ismail N. MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. Plos Pathogens. 13: e1006644. PMID 29049365 DOI: 10.1371/journal.ppat.1006644  0.4
2017 Yates CC, Rodrigues M, Nuschke A, Johnson ZI, Whaley D, Stolz D, Newsome J, Wells A. Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring. Stem Cell Research & Therapy. 8: 193. PMID 28874184 DOI: 10.1186/s13287-017-0644-9  0.96
2017 Shao H, Lauffenburger D, Wells A. Tyro3 carboxyl terminal region confers stability and contains the autophosphorylation sites. Biochemical and Biophysical Research Communications. PMID 28668391 DOI: 10.1016/j.bbrc.2017.06.168  0.48
2017 Wells A, Ma B. Friend turned foe: E-cadherin perversely protects micrometastases. Translational Andrology and Urology. 6: 338-340. PMID 28540251 DOI: 10.21037/tau.2017.03.25  0.48
2016 Nuschke A, Rodrigues M, Wells AW, Sylakowski K, Wells A. Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation. Stem Cell Research & Therapy. 7: 179. PMID 27906055 DOI: 10.1186/s13287-016-0436-7  0.96
2016 Ma B, Wheeler SE, Clark AM, Whaley DL, Yang M, Wells A. Liver Protects Metastatic Prostate Cancer From Induced Death by Activating E-cadherin Signaling. Hepatology (Baltimore, Md.). PMID 27482645 DOI: 10.1002/hep.28755  0.96
2016 Yates CC, Nuschke A, Rodrigues M, Whaley D, Dechant JJ, Taylor DP, Wells A. Improved transplanted stem cell survival in a polymer gel supplemented with tenascin-C accelerates healing and reduces scarring of murine skin wounds. Cell Transplantation. PMID 27452449 DOI: 10.3727/096368916X692249  0.96
2016 Nuschke A, Rodrigues M, Rivera J, Yates C, Whaley D, Stolz D, Griffith L, Wells A. Epidermal Growth Factor Tethered to β-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. Stem Cells Translational Medicine. PMID 27400798 DOI: 10.5966/sctm.2015-0326  0.96
2016 Clark AM, Ma B, Taylor DL, Griffith L, Wells A. Liver metastases: Microenvironments and ex-vivo models. Experimental Biology and Medicine (Maywood, N.J.). PMID 27390264 DOI: 10.1177/1535370216658144  0.96
2016 Yang M, Ma B, Shao H, Clark AM, Wells A. Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. Bmc Cancer. 16: 419. PMID 27387344 DOI: 10.1186/s12885-016-2411-1  0.96
2016 Bodnar RJ, Satish L, Yates CC, Wells A. Pericytes: A newly recognized player in wound healing. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. PMID 26969517 DOI: 10.1111/wrr.12415  0.4
2015 Gordonov S, Hwang MK, Wells A, Gertler FB, Lauffenburger DA, Bathe M. Time series modeling of live-cell shape dynamics for image-based phenotypic profiling. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 26658688 DOI: 10.1039/c5ib00283d  0.44
2015 Wells A, Nuschke A, Yates CC. Skin tissue repair: Matrix microenvironmental influences. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26278492 DOI: 10.1016/j.matbio.2015.08.001  0.96
2015 Bodnar RJ, Wells A. Differential regulation of pericyte function by the CXC receptor 3. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. PMID 26207932 DOI: 10.1111/wrr.12346  0.4
2015 Travers T, Shao H, Joughin BA, Lauffenburger DA, Wells A, Camacho CJ. Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. Science Signaling. 8: ra51. PMID 26012634 DOI: 10.1126/scisignal.aaa1977  0.96
2015 Ma B, Khazali A, Wells A. CXCR3 in carcinoma progression. Histology and Histopathology. 30: 781-92. PMID 25663474 DOI: 10.14670/HH-11-594  0.48
2015 Furukawa M, Wheeler S, Clark AM, Wells A. Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells. Plos One. 10: e0118060. PMID 25635394 DOI: 10.1371/journal.pone.0118060  0.96
2014 Nuschke A, Rodrigues M, Stolz DB, Chu CT, Griffith L, Wells A. Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. Stem Cell Research & Therapy. 5: 140. PMID 25523618 DOI: 10.1186/scrt530  0.96
2014 Shao H, Li S, Watkins SC, Wells A. α-Actinin-4 is required for amoeboid-type invasiveness of melanoma cells. The Journal of Biological Chemistry. 289: 32717-28. PMID 25296750 DOI: 10.1074/jbc.M114.579185  0.96
2014 Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A. A microphysiological system model of therapy for liver micrometastases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1170-9. PMID 24821820 DOI: 10.1177/1535370214532596  0.96
2014 Jamison J, Wang JH, Wells A. PKCδ regulates force signaling during VEGF/CXCL4 induced dissociation of endothelial tubes. Plos One. 9: e93968. PMID 24699667 DOI: 10.1371/journal.pone.0093968  0.96
2014 Griffith LG, Wells A, Stolz DB. Engineering liver. Hepatology (Baltimore, Md.). 60: 1426-34. PMID 24668880 DOI: 10.1002/hep.27150  0.52
2014 Ma B, Wells A. The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells. The Journal of Biological Chemistry. 289: 11153-61. PMID 24619413 DOI: 10.1074/jbc.M113.540237  0.48
2014 Taylor DP, Clark A, Wheeler S, Wells A. Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Breast Cancer Research and Treatment. 144: 551-60. PMID 24610032 DOI: 10.1007/s10549-014-2875-0  0.48
2014 Grahovac J, Wells A. Matrikine and matricellular regulators of EGF receptor signaling on cancer cell migration and invasion. Laboratory Investigation; a Journal of Technical Methods and Pathology. 94: 31-40. PMID 24247562 DOI: 10.1038/labinvest.2013.132  0.96
2013 Wheeler SE, Borenstein JT, Clark AM, Ebrahimkhani MR, Fox IJ, Griffith L, Inman W, Lauffenburger D, Nguyen T, Pillai VC, Prantil-Baun R, Stolz DB, Taylor D, Ulrich T, Venkataramanan R, ... Wells A, et al. All-human microphysical model of metastasis therapy. Stem Cell Research & Therapy. 4: S11. PMID 24565274 DOI: 10.1186/scrt372  0.96
2013 Jamison J, Lauffenburger D, Wang JC, Wells A. PKCδ localization at the membrane increases matrix traction force dependent on PLCγ1/EGFR signaling. Plos One. 8: e77434. PMID 24155954 DOI: 10.1371/journal.pone.0077434  0.48
2013 Bodnar RJ, Rodgers ME, Chen WC, Wells A. Pericyte regulation of vascular remodeling through the CXC receptor 3. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2818-29. PMID 24135023 DOI: 10.1161/ATVBAHA.113.302012  0.96
2013 Hang TC, Tedford NC, Reddy RJ, Rimchala T, Wells A, White FM, Kamm RD, Lauffenburger DA. Vascular endothelial growth factor (VEGF) and platelet (PF-4) factor 4 inputs modulate human microvascular endothelial signaling in a three-dimensional matrix migration context. Molecular & Cellular Proteomics : McP. 12: 3704-18. PMID 24023389 DOI: 10.1074/mcp.M113.030528  0.96
2013 Wells A, Griffith L, Wells JZ, Taylor DP. The dormancy dilemma: quiescence versus balanced proliferation. Cancer Research. 73: 3811-6. PMID 23794703 DOI: 10.1158/0008-5472.CAN-13-0356  0.84
2013 Wells A, Grahovac J, Wheeler S, Ma B, Lauffenburger D. Targeting tumor cell motility as a strategy against invasion and metastasis. Trends in Pharmacological Sciences. 34: 283-9. PMID 23571046 DOI: 10.1016/  0.96
2013 Rodrigues M, Yates CC, Nuschke A, Griffith L, Wells A. The matrikine tenascin-C protects multipotential stromal cells/mesenchymal stem cells from death cytokines such as FasL. Tissue Engineering. Part A. 19: 1972-83. PMID 23541003 DOI: 10.1089/ten.TEA.2012.0568  0.96
2013 Shao H, Travers T, Camacho CJ, Wells A. The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading. The International Journal of Biochemistry & Cell Biology. 45: 1051-63. PMID 23466492 DOI: 10.1016/j.biocel.2013.02.015  0.96
2013 Travers T, Shao H, Wells A, Camacho CJ. Modeling the assembly of the multiple domains of α-actinin-4 and its role in actin cross-linking. Biophysical Journal. 104: 705-15. PMID 23442921 DOI: 10.1016/j.bpj.2012.12.003  0.96
2013 Taylor DP, Wells JZ, Savol A, Chennubhotla C, Wells A. Modeling boundary conditions for balanced proliferation in metastatic latency. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 1063-70. PMID 23329811 DOI: 10.1158/1078-0432.CCR-12-3180  0.48
2013 Grahovac J, Becker D, Wells A. Melanoma cell invasiveness is promoted at least in part by the epidermal growth factor-like repeats of tenascin-C. The Journal of Investigative Dermatology. 133: 210-20. PMID 22951722 DOI: 10.1038/jid.2012.263  0.96
2013 Rodrigues M, Blair H, Stockdale L, Griffith L, Wells A. Surface tethered epidermal growth factor protects proliferating and differentiating multipotential stromal cells from FasL-induced apoptosis. Stem Cells (Dayton, Ohio). 31: 104-16. PMID 22948863 DOI: 10.1002/stem.1215  0.96
2012 Yates CC, Hebda P, Wells A. Skin wound healing and scarring: fetal wounds and regenerative restitution. Birth Defects Research. Part C, Embryo Today : Reviews. 96: 325-33. PMID 24203921 DOI: 10.1002/bdrc.21024  0.96
2012 Jones J, Wang H, Zhou J, Hardy S, Turner T, Austin D, He Q, Wells A, Grizzle WE, Yates C. Nuclear Kaiso indicates aggressive prostate cancers and promotes migration and invasiveness of prostate cancer cells. The American Journal of Pathology. 181: 1836-46. PMID 22974583 DOI: 10.1016/j.ajpath.2012.08.008  0.96
2012 Yates-Binder CC, Rodgers M, Jaynes J, Wells A, Bodnar RJ, Turner T. An IP-10 (CXCL10)-derived peptide inhibits angiogenesis. Plos One. 7: e40812. PMID 22815829 DOI: 10.1371/journal.pone.0040812  0.96
2012 Gunasinghe NP, Wells A, Thompson EW, Hugo HJ. Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer. Cancer Metastasis Reviews. 31: 469-78. PMID 22729277 DOI: 10.1007/s10555-012-9377-5  0.96
2012 Wells A. Laboratory medicine: a view to the future of diagnostics and training. Rinsho Byori. the Japanese Journal of Clinical Pathology. 60: 312-20. PMID 22686040  0.96
2012 Meyer AS, Hughes-Alford SK, Kay JE, Castillo A, Wells A, Gertler FB, Lauffenburger DA. 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. The Journal of Cell Biology. 197: 721-9. PMID 22665521 DOI: 10.1083/jcb.201201003  0.96
2012 Rodrigues M, Turner O, Stolz D, Griffith LG, Wells A. Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand. Cell Transplantation. 21: 2171-87. PMID 22526333 DOI: 10.3727/096368912X639035  0.88
2012 Wu Q, Dhir R, Wells A. Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. Molecular Cancer. 11: 3. PMID 22236567 DOI: 10.1186/1476-4598-11-3  0.44
2012 Yates CC, Whaley D, Wells A. Transplanted fibroblasts prevents dysfunctional repair in a murine CXCR3-deficient scarring model. Cell Transplantation. 21: 919-31. PMID 22236446 DOI: 10.3727/096368911X623817  0.96
2012 Chao Y, Wu Q, Shepard C, Wells A. Hepatocyte induced re-expression of E-cadherin in breast and prostate cancer cells increases chemoresistance Clinical and Experimental Metastasis. 29: 39-50. PMID 21964676 DOI: 10.1007/s10585-011-9427-3  0.96
2012 Chao Y, Wu Q, Acquafondata M, Dhir R, Wells A. Partial mesenchymal to epithelial reverting transition in breast and prostate cancer metastases. Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society. 5: 19-28. PMID 21892699 DOI: 10.1007/s12307-011-0085-4  0.44
2011 Kim HD, Meyer AS, Wagner JP, Alford SK, Wells A, Gertler FB, Lauffenburger DA. Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts. Molecular & Cellular Proteomics : McP. 10: M111.008433. PMID 21832255 DOI: 10.1074/mcp.M111.008433  0.96
2011 Wu S, Wells A, Griffith LG, Lauffenburger DA. Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. Biomaterials. 32: 7524-31. PMID 21782235 DOI: 10.1016/j.biomaterials.2011.06.050  0.96
2011 Yates CC, Bodnar R, Wells A. Matrix control of scarring. Cellular and Molecular Life Sciences : Cmls. 68: 1871-81. PMID 21390544 DOI: 10.1007/s00018-011-0663-0  0.96
2011 Leloup L, Wells A. Calpains as potential anti-cancer targets. Expert Opinion On Therapeutic Targets. 15: 309-23. PMID 21244345 DOI: 10.1517/14728222.2011.553611  0.96
2011 Wells A, Chao YL, Grahovac J, Wu Q, Lauffenburger DA. Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. Frontiers in Bioscience (Landmark Edition). 16: 815-37. PMID 21196205 DOI: 10.2741/3722  0.96
2010 Bae YH, Ding Z, Das T, Wells A, Gertler F, Roy P. Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 21547-52. PMID 21115820 DOI: 10.1073/pnas.1002309107  0.96
2010 Shao H, Wang JH, Pollak MR, Wells A. α-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts. Plos One. 5: e13921. PMID 21085685 DOI: 10.1371/journal.pone.0013921  0.96
2010 Rodrigues M, Griffith LG, Wells A. Growth factor regulation of proliferation and survival of multipotential stromal cells. Stem Cell Research & Therapy. 1: 32. PMID 20977782 DOI: 10.1186/scrt32  0.88
2010 Silver K, Leloup L, Freeman LC, Wells A, Lillich JD. Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease. The International Journal of Biochemistry & Cell Biology. 42: 2030-6. PMID 20854926 DOI: 10.1016/j.biocel.2010.09.007  0.96
2010 Krishna P, Regner M, Palko J, Liu F, Abramowitch S, Jiang J, Wells A. The effects of decorin and HGF-primed vocal fold fibroblasts in vitro and ex vivo in a porcine model of vocal fold scarring. The Laryngoscope. 120: 2247-57. PMID 20830759 DOI: 10.1002/lary.21087  0.96
2010 Leloup L, Shao H, Bae YH, Deasy B, Stolz D, Roy P, Wells A. m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate. The Journal of Biological Chemistry. 285: 33549-66. PMID 20729206 DOI: 10.1074/jbc.M110.123604  0.4
2010 Chao YL, Shepard CR, Wells A. Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Molecular Cancer. 9: 179. PMID 20609236 DOI: 10.1186/1476-4598-9-179  0.96
2010 Hood BL, Grahovac J, Flint MS, Sun M, Charro N, Becker D, Wells A, Conrads TP. Proteomic analysis of laser microdissected melanoma cells from skin organ cultures. Journal of Proteome Research. 9: 3656-63. PMID 20459140 DOI: 10.1021/pr100164x  0.96
2010 Yates CC, Krishna P, Whaley D, Bodnar R, Turner T, Wells A. Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring. The American Journal of Pathology. 176: 1743-55. PMID 20203286 DOI: 10.2353/ajpath.2010.090564  0.96
2010 Li M, Aliotta JM, Asara JM, Wu Q, Dooner MS, Tucker LD, Wells A, Quesenberry PJ, Ramratnam B. Intercellular transfer of proteins as identified by stable isotope labeling of amino acids in cell culture. The Journal of Biological Chemistry. 285: 6285-97. PMID 20026604 DOI: 10.1074/jbc.M109.057943  0.44
2009 Platt MO, Wilder CL, Wells A, Griffith LG, Lauffenburger DA. Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells. Stem Cells (Dayton, Ohio). 27: 2804-14. PMID 19750537 DOI: 10.1002/stem.215  0.96
2009 Platt MO, Roman AJ, Wells A, Lauffenburger DA, Griffith LG. Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells. Journal of Cellular Physiology. 221: 306-17. PMID 19544388 DOI: 10.1002/jcp.21854  0.96
2009 Marcantonio NA, Boehm CA, Rozic RJ, Au A, Wells A, Muschler GF, Griffith LG. The influence of tethered epidermal growth factor on connective tissue progenitor colony formation. Biomaterials. 30: 4629-38. PMID 19540579 DOI: 10.1016/j.biomaterials.2009.05.061  0.96
2009 Bodnar RJ, Yates CC, Rodgers ME, Du X, Wells A. IP-10 induces dissociation of newly formed blood vessels. Journal of Cell Science. 122: 2064-77. PMID 19470579 DOI: 10.1242/jcs.048793  0.96
2009 Yates CC, Whaley D, Hooda S, Hebda PA, Bodnar RJ, Wells A. Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 17: 34-41. PMID 19152649 DOI: 10.1111/j.1524-475X.2008.00439.x  0.96
2009 Bae YH, Ding Z, Zou L, Wells A, Gertler F, Roy P. Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins. Journal of Cellular Physiology. 219: 354-64. PMID 19115233 DOI: 10.1002/jcp.21677  0.96
2008 Yates CC, Whaley D, Y-Chen A, Kulesekaran P, Hebda PA, Wells A. ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. The American Journal of Pathology. 173: 643-52. PMID 18669615 DOI: 10.2353/ajpath.2008.070990  0.96
2008 Kim HD, Guo TW, Wu AP, Wells A, Gertler FB, Lauffenburger DA. Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Molecular Biology of the Cell. 19: 4249-59. PMID 18632979 DOI: 10.1091/mbc.E08-05-0501  0.96
2008 Mi Z, Holmes FA, Hellerstedt B, Pippen J, Collea R, Backner A, Bush JE, Gallion HH, Wells A, O'Shaughnessy JA. Feasibility assessment of a chemoresponse assay to predict pathologic response in neoadjuvant chemotherapy for breast cancer patients. Anticancer Research. 28: 1733-40. PMID 18630452  0.96
2008 Wells A, Yates C, Shepard CR. E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clinical & Experimental Metastasis. 25: 621-8. PMID 18600305 DOI: 10.1007/s10585-008-9167-1  0.64
2008 Nozawa H, Howell G, Suzuki S, Zhang Q, Qi Y, Klein-Seetharaman J, Wells A, Grandis JR, Thomas SM. Combined inhibition of PLC{gamma}-1 and c-Src abrogates epidermal growth factor receptor-mediated head and neck squamous cell carcinoma invasion. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4336-44. PMID 18594017 DOI: 10.1158/1078-0432.CCR-07-4857  0.44
2008 Sharrow AC, Li Y, Micsenyi A, Griswold RD, Wells A, Monga SS, Blair HC. Modulation of osteoblast gap junction connectivity by serum, TNFalpha, and TRAIL. Experimental Cell Research. 314: 297-308. PMID 18022159 DOI: 10.1016/j.yexcr.2007.10.010  0.96
2008 Iyer AK, Tran KT, Griffith L, Wells A. Cell surface restriction of EGFR by a tenascin cytotactin-encoded EGF-like repeat is preferential for motility-related signaling. Journal of Cellular Physiology. 214: 504-12. PMID 17708541 DOI: 10.1002/jcp.21232  0.96
2007 Joslin EJ, Opresko LK, Wells A, Wiley HS, Lauffenburger DA. EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. Journal of Cell Science. 120: 3688-99. PMID 17895366 DOI: 10.1242/jcs.010488  0.96
2007 Yaroslavskiy BB, Sharrow AC, Wells A, Robinson LJ, Blair HC. Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility. Journal of Cell Science. 120: 2884-94. PMID 17690304 DOI: 10.1242/jcs.004184  0.96
2007 Yates CC, Whaley D, Kulasekeran P, Hancock WW, Lu B, Bodnar R, Newsome J, Hebda PA, Wells A. Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. The American Journal of Pathology. 171: 484-95. PMID 17600132 DOI: 10.2353/ajpath.2007.061092  0.96
2007 Blair HC, Wells A, Isales CM. Pituitary glycoprotein hormone receptors in non-endocrine organs. Trends in Endocrinology and Metabolism: Tem. 18: 227-33. PMID 17588768 DOI: 10.1016/j.tem.2007.06.001  0.96
2007 Yates CC, Whaley D, Babu R, Zhang J, Krishna P, Beckman E, Pasculle AW, Wells A. The effect of multifunctional polymer-based gels on wound healing in full thickness bacteria-contaminated mouse skin wound models. Biomaterials. 28: 3977-86. PMID 17561250 DOI: 10.1016/j.biomaterials.2007.05.008  0.96
2007 Yates C, Shepard CR, Papworth G, Dash A, Beer Stolz D, Tannenbaum S, Griffith L, Wells A. Novel three-dimensional organotypic liver bioreactor to directly visualize early events in metastatic progression. Advances in Cancer Research. 97: 225-46. PMID 17419948 DOI: 10.1016/S0065-230X(06)97010-9  0.96
2007 Kharait S, Hautaniemi S, Wu S, Iwabu A, Lauffenburger DA, Wells A. Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility. Bmc Systems Biology. 1: 9. PMID 17408516 DOI: 10.1186/1752-0509-1-9  0.96
2007 Yates CC, Shepard CR, Stolz DB, Wells A. Co-culturing human prostate carcinoma cells with hepatocytes leads to increased expression of E-cadherin. British Journal of Cancer. 96: 1246-52. PMID 17406365 DOI: 10.1038/sj.bjc.6603700  0.96
2007 Iyer AK, Tran KT, Borysenko CW, Cascio M, Camacho CJ, Blair HC, Bahar I, Wells A. Tenascin cytotactin epidermal growth factor-like repeat binds epidermal growth factor receptor with low affinity. Journal of Cellular Physiology. 211: 748-58. PMID 17311283 DOI: 10.1002/jcp.20986  0.96
2007 Fan VH, Tamama K, Au A, Littrell R, Richardson LB, Wright JW, Wells A, Griffith LG. Tethered epidermal growth factor provides a survival advantage to mesenchymal stem cells. Stem Cells (Dayton, Ohio). 25: 1241-51. PMID 17234993 DOI: 10.1634/stemcells.2006-0320  0.52
2006 Krishna P, Rosen CA, Branski RC, Wells A, Hebda PA. Primed fibroblasts and exogenous decorin: potential treatments for subacute vocal fold scar. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 135: 937-45. PMID 17141088 DOI: 10.1016/j.otohns.2006.07.011  0.96
2006 Satish L, Lyons-Weiler J, Hebda PA, Wells A. Gene expression patterns in isolated keloid fibroblasts. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 14: 463-70. PMID 16939575 DOI: 10.1111/j.1743-6109.2006.00135.x  0.76
2006 Zaman MH, Trapani LM, Sieminski AL, Siemeski A, Mackellar D, Gong H, Kamm RD, Wells A, Lauffenburger DA, Matsudaira P. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 103: 10889-94. PMID 16832052 DOI: 10.1073/pnas.0604460103  0.96
2006 Shao H, Chou J, Baty CJ, Burke NA, Watkins SC, Stolz DB, Wells A. Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation. Molecular and Cellular Biology. 26: 5481-96. PMID 16809781 DOI: 10.1128/MCB.02243-05  0.44
2006 Zhou W, Grandis JR, Wells A. STAT3 is required but not sufficient for EGF receptor-mediated migration and invasion of human prostate carcinoma cell lines. British Journal of Cancer. 95: 164-71. PMID 16804520 DOI: 10.1038/sj.bjc.6603234  0.44
2006 Wells A, Harms B, Iwabu A, Koo L, Smith K, Griffith L, Lauffenburger DA. Motility signaled from the EGF receptor and related systems Methods in Molecular Biology (Clifton, N.J.). 327: 159-177. PMID 16780220  0.96
2006 Smith KD, Wells A, Lauffenburger DA. Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts Experimental Cell Research. 312: 1970-1982. PMID 16595133 DOI: 10.1016/j.yexcr.2006.02.022  0.96
2006 Kharait S, Dhir R, Lauffenburger D, Wells A. Protein kinase Cdelta signaling downstream of the EGF receptor mediates migration and invasiveness of prostate cancer cells. Biochemical and Biophysical Research Communications. 343: 848-56. PMID 16564022 DOI: 10.1016/j.bbrc.2006.03.044  0.48
2006 Bodnar RJ, Yates CC, Wells A. IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circulation Research. 98: 617-25. PMID 16484616 DOI: 10.1161/01.RES.0000209968.66606.10  0.96
2006 Tamama K, Fan VH, Griffith LG, Blair HC, Wells A. Epidermal growth factor as a candidate for ex vivo expansion of bone marrow-derived mesenchymal stem cells. Stem Cells (Dayton, Ohio). 24: 686-95. PMID 16150920 DOI: 10.1634/stemcells.2005-0176  0.96
2005 Wells A, Huttenlocher A, Lauffenburger DA. Calpain proteases in cell adhesion and motility International Review of Cytology. 245: 1-16. PMID 16125543 DOI: 10.1016/S0074-7696(05)45001-9  0.96
2005 Wang J, Zhang X, Thomas SM, Grandis JR, Wells A, Chen ZG, Ferris RL. Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. Oncogene. 24: 5897-904. PMID 16007209 DOI: 10.1038/sj.onc.1208740  0.44
2005 Lai SY, Childs EE, Xi S, Coppelli FM, Gooding WE, Wells A, Ferris RL, Grandis JR. Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma. Oncogene. 24: 4442-9. PMID 15856028 DOI: 10.1038/sj.onc.1208635  0.44
2005 Satish L, Blair HC, Glading A, Wells A. Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain. Molecular and Cellular Biology. 25: 1922-41. PMID 15713646 DOI: 10.1128/MCB.25.5.1922-1941.2005  0.96
2005 Hautaniemi S, Kharait S, Iwabu A, Wells A, Lauffenburger DA. Modeling of signal-response cascades using decision tree analysis Bioinformatics. 21: 2027-2035. PMID 15657095 DOI: 10.1093/bioinformatics/bti278  0.96
2005 Hendriks BS, Orr G, Wells A, Wiley HS, Lauffenburger DA. Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells. The Journal of Biological Chemistry. 280: 6157-69. PMID 15572377 DOI: 10.1074/jbc.M410491200  0.44
2005 Wells A. EGFR in metastasis Signal. 6: 17-19.  0.96
2004 Tran KT, Griffith L, Wells A. Extracellular matrix signaling through growth factor receptors during wound healing. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 12: 262-8. PMID 15225204 DOI: 10.1111/j.1067-1927.2004.012302.x  0.96
2004 Satish L, Babu M, Tran KT, Hebda PA, Wells A. Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 12: 183-92. PMID 15086770 DOI: 10.1111/j.1067-1927.2004.012111.x  0.96
2004 Iwabu A, Smith K, Allen FD, Lauffenburger DA, Wells A. Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. The Journal of Biological Chemistry. 279: 14551-60. PMID 14747473 DOI: 10.1074/jbc.M311981200  0.44
2003 Thomas SM, Coppelli FM, Wells A, Gooding WE, Song J, Kassis J, Drenning SD, Grandis JR. Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma. Cancer Research. 63: 5629-35. PMID 14500405  0.44
2003 Tran KT, Rusu SD, Satish L, Wells A. Aging-related attenuation of EGF receptor signaling is mediated in part by increased protein tyrosine phosphatase activity. Experimental Cell Research. 289: 359-67. PMID 14499637 DOI: 10.1016/S0014-4827(03)00287-8  0.96
2003 Mamoune A, Luo JH, Lauffenburger DA, Wells A. Calpain-2 as a target for limiting prostate cancer invasion. Cancer Research. 63: 4632-40. PMID 12907643  0.44
2003 Lauffenburger DA, Wells A. Quantitative parsing of cell multi-tasking in wound repair and tissue morphogenesis. Biophysical Journal. 84: 3499-500. PMID 12770862  0.44
2002 Wells A, Kassis J, Solava J, Turner T, Lauffenburger DA. Growth factor-induced cell motility in tumor invasion. Acta Oncologica (Stockholm, Sweden). 41: 124-30. PMID 12102155  0.44
2002 Allen FD, Asnes CF, Chang P, Elson EL, Lauffenburger DA, Wells A. Epidermal growth factor induces acute matrix contraction and subsequent calpain-modulated relaxation. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 10: 67-76. PMID 11983008 DOI: 10.1046/j.1524-475X.2002.10701.x  0.96
2002 Glading A, Lauffenburger DA, Wells A. Cutting to the chase: calpain proteases in cell motility. Trends in Cell Biology. 12: 46-54. PMID 11854009  0.44
2001 Swindle CS, Tran KT, Johnson TD, Banerjee P, Mayes AM, Griffith L, Wells A. Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. The Journal of Cell Biology. 154: 459-68. PMID 11470832 DOI: 10.1083/jcb.200103103  0.96
1999 Wells A. Tumor Invasion: Role of growth factor-induced cell motility Advances in Cancer Research. 78: 31-101. PMID 10547668  0.96
1998 Wells A. Introduction to cell motility Microscopy Research and Technique. 43: 357. DOI: 10.1002/(SICI)1097-0029(19981201)43:5<357::AID-JEMT1>3.0.CO;2-H  0.96
1989 Wells A. The epidermal growth factor receptor and its ligands Cancer Treatment and Research. 47: 143-168. PMID 2576995  0.96
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