Shuxing Zhang, Ph.D. - Publications

2005 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Pharmaceutical Chemistry, Biostatistics Biology, Computer Science, Artificial Intelligence

26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB. 3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells. The Journal of Biological Chemistry. 291: 16926. PMID 27496967 DOI: 10.1074/jbc.A111.274613  1
2015 Morrow JK, Lin HK, Sun SC, Zhang S. Targeting ubiquitination for cancer therapies. Future Medicinal Chemistry. PMID 26630263 DOI: 10.4155/fmc.15.148  1
2015 Chen L, Du-Cuny L, Moses S, Dumas S, Song Z, Rezaeian AH, Lin HK, Meuillet EJ, Zhang S. Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cells. Plos Computational Biology. 11: e1004021. PMID 25569504 DOI: 10.1371/journal.pcbi.1004021  1
2014 Chan CH, Morrow JK, Zhang S, Lin HK. Skp2: a dream target in the coming age of cancer therapy. Cell Cycle (Georgetown, Tex.). 13: 679-80. PMID 24526126 DOI: 10.4161/cc.27853  1
2013 De S, Chen L, Zhang S, Gilbertson SR. Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones. Acs Combinatorial Science. 15: 340-3. PMID 23742807 DOI: 10.1021/co400067q  1
2012 Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ. Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. Proceedings of the National Academy of Sciences of the United States of America. 109: 13016-21. PMID 22826236 DOI: 10.1073/pnas.1120299109  1
2012 Ihle NT, Byers LA, Kim ES, Saintigny P, Lee JJ, Blumenschein GR, Tsao A, Liu S, Larsen JE, Wang J, Diao L, Coombes KR, Chen L, Zhang S, Abdelmelek MF, et al. Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. Journal of the National Cancer Institute. 104: 228-39. PMID 22247021 DOI: 10.1093/jnci/djr523  1
2011 Tran HT, Zhang S. Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility. Journal of Chemical Information and Modeling. 51: 2352-60. PMID 21834588 DOI: 10.1021/ci2001742  1
2011 Khalaf J, Estrella-Jimenez ME, Shashack MJ, Phatak SS, Zhang S, Gilbertson SR. Design, synthesis, and diversification of 3,5-substituted enone library. Acs Combinatorial Science. 13: 351-6. PMID 21648460 DOI: 10.1021/co200070m  1
2011 Ahad AM, Zuohe S, Du-Cuny L, Moses SA, Zhou LL, Zhang S, Powis G, Meuillet EJ, Mash EA. Development of sulfonamide AKT PH domain inhibitors. Bioorganic & Medicinal Chemistry. 19: 2046-54. PMID 21353784 DOI: 10.1016/j.bmc.2011.01.049  1
2011 Zhang S. Computer-aided drug discovery and development. Methods in Molecular Biology (Clifton, N.J.). 716: 23-38. PMID 21318898 DOI: 10.1007/978-1-61779-012-6_2  1
2011 Morrow JK, Du-Cuny L, Chen L, Meuillet EJ, Mash EA, Powis G, Zhang S. Recent development of anticancer therapeutics targeting Akt. Recent Patents On Anti-Cancer Drug Discovery. 6: 146-59. PMID 21110830 DOI: 10.2174/157489211793980079  1
2010 Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, et al. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Molecular Cancer Therapeutics. 9: 706-17. PMID 20197390 DOI: 10.1158/1535-7163.MCT-09-0985  1
2010 Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi V. Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochemical Pharmacology. 79: 669-77. PMID 19814999 DOI: 10.1016/j.bcp.2009.09.028  1
2009 Du-Cuny L, Song Z, Moses S, Powis G, Mash EA, Meuillet EJ, Zhang S. Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & Medicinal Chemistry. 17: 6983-92. PMID 19734051 DOI: 10.1016/j.bmc.2009.08.022  1
2009 Moses SA, Ali MA, Zuohe S, Du-Cuny L, Zhou LL, Lemos R, Ihle N, Skillman AG, Zhang S, Mash EA, Powis G, Meuillet EJ. In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT. Cancer Research. 69: 5073-81. PMID 19491272 DOI: 10.1158/0008-5472.CAN-08-3839  1
2009 Chen LS, Nowak BJ, Ayres ML, Krett NL, Rosen ST, Zhang S, Gandhi V. Inhibition of ATP synthase by chlorinated adenosine analogue. Biochemical Pharmacology. 78: 583-91. PMID 19477165 DOI: 10.1016/j.bcp.2009.05.019  1
2008 Mahadevan D, Powis G, Mash EA, George B, Gokhale VM, Zhang S, Shakalya K, Du-Cuny L, Berggren M, Ali MA, Jana U, Ihle N, Moses S, Franklin C, Narayan S, et al. Discovery of a novel class of AKT pleckstrin homology domain inhibitors. Molecular Cancer Therapeutics. 7: 2621-32. PMID 18790745 DOI: 10.1158/1535-7163.MCT-07-2276  1
2008 Zhang S, Kaplan AH, Tropsha A. HIV-1 protease function and structure studies with the simplicial neighborhood analysis of protein packing method. Proteins. 73: 742-53. PMID 18498108 DOI: 10.1002/prot.22094  1
2007 Zhang S, Wei L, Bastow K, Zheng W, Brossi A, Lee KH, Tropsha A. Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents. Journal of Computer-Aided Molecular Design. 21: 97-112. PMID 17340042 DOI: 10.1007/s10822-007-9102-6  1
2006 Zhang S, Golbraikh A, Oloff S, Kohn H, Tropsha A. A novel automated lazy learning QSAR (ALL-QSAR) approach: method development, applications, and virtual screening of chemical databases using validated ALL-QSAR models. Journal of Chemical Information and Modeling. 46: 1984-95. PMID 16995729 DOI: 10.1021/ci060132x  1
2006 Zhang S, Golbraikh A, Tropsha A. Development of quantitative structure-binding affinity relationship models based on novel geometrical chemical descriptors of the protein-ligand interfaces. Journal of Medicinal Chemistry. 49: 2713-24. PMID 16640331 DOI: 10.1021/jm050260x  1
2006 Oloff S, Zhang S, Sukumar N, Breneman C, Tropsha A. Chemometric analysis of ligand receptor complementarity: identifying Complementary Ligands Based on Receptor Information (CoLiBRI). Journal of Chemical Information and Modeling. 46: 844-51. PMID 16563016 DOI: 10.1021/ci050065r  1
2005 Miller BM, Zhang S, Suggs JA, Swank DM, Littlefield KP, Knowles AF, Bernstein SI. An alternative domain near the nucleotide-binding site of Drosophila muscle myosin affects ATPase kinetics. Journal of Molecular Biology. 353: 14-25. PMID 16154586 DOI: 10.1016/j.jmb.2005.08.012  1
2004 Sherman DB, Zhang S, Pitner JB, Tropsha A. Evaluation of the relative stability of liganded versus ligand-free protein conformations using Simplicial Neighborhood Analysis of Protein Packing (SNAPP) method. Proteins. 56: 828-38. PMID 15281134 DOI: 10.1002/prot.20131  1
2000 Zhang SX, Feng J, Kuo SC, Brossi A, Hamel E, Tropsha A, Lee KH. Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis. Journal of Medicinal Chemistry. 43: 167-76. PMID 10649972 DOI: 10.1021/jm990333a  0.32
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