| Year |
Citation |
Score |
| 2023 |
Yao CH, Park JS, Kurmi K, Hu SH, Notarangelo G, Crowley J, Jacobson H, Hui S, Sharpe AH, Haigis MC. Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis. Molecular Cell. 83: 1340-1349.e7. PMID 37084714 DOI: 10.1016/j.molcel.2023.03.023 |
0.301 |
|
| 2023 |
Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, ... ... Haigis MC, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell Metabolism. PMID 37075753 DOI: 10.1016/j.cmet.2023.03.018 |
0.481 |
|
| 2023 |
Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, ... ... Haigis MC, et al. FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Biorxiv : the Preprint Server For Biology. PMID 36865221 DOI: 10.1101/2023.02.19.529127 |
0.489 |
|
| 2023 |
Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, ... ... Haigis MC, et al. NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metabolism. PMID 36841242 DOI: 10.1016/j.cmet.2023.01.012 |
0.303 |
|
| 2022 |
Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, ... ... Haigis MC, et al. Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function. Science (New York, N.Y.). 377: 1519-1529. PMID 36173860 DOI: 10.1126/science.abj5104 |
0.695 |
|
| 2022 |
Kang YH, Tucker SA, Quevedo SF, Inal A, Korzenik JR, Haigis MC. Metabolic analyses reveal dysregulated NAD+ metabolism and altered mitochondrial state in ulcerative colitis. Plos One. 17: e0273080. PMID 35976971 DOI: 10.1371/journal.pone.0273080 |
0.305 |
|
| 2021 |
van Gastel N, Spinelli JB, Haigis MC, Scadden DT. Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice. Bio-Protocol. 11: e4171. PMID 34722818 DOI: 10.21769/BioProtoc.4171 |
0.324 |
|
| 2021 |
Zaganjor E, Yoon H, Spinelli JB, Nunn ER, Laurent G, Keskinidis P, Sivaloganathan S, Joshi S, Notarangelo G, Mulei S, Chvasta MT, Tucker SA, Kalafut K, van de Ven RAH, Clish CB, ... Haigis MC, et al. SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis. Cell Reports. 36: 109345. PMID 34260923 DOI: 10.1016/j.celrep.2021.109345 |
0.724 |
|
| 2021 |
Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, ... ... Haigis M, et al. Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. PMID 34216539 DOI: 10.1016/j.cell.2021.05.045 |
0.312 |
|
| 2021 |
Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, ... ... Haigis MC, et al. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372: 716-721. PMID 33986176 DOI: 10.1126/science.aaz2740 |
0.332 |
|
| 2021 |
Elia I, Haigis MC. Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism. Nature Metabolism. PMID 33398194 DOI: 10.1038/s42255-020-00317-z |
0.35 |
|
| 2020 |
van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, ... Haigis MC, et al. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metabolism. PMID 32763164 DOI: 10.1016/J.Cmet.2020.07.009 |
0.452 |
|
| 2020 |
Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, ... ... Haigis MC, et al. PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metabolism. PMID 32663458 DOI: 10.1016/J.Cmet.2020.06.017 |
0.708 |
|
| 2020 |
Chen H, Shi Z, Guo J, Chang KJ, Chen Q, Yao CH, Haigis MC, Shi Y. The human mitochondrial 12S rRNA mC methyltransferase METTL15 is required for mitochondrial function. The Journal of Biological Chemistry. PMID 32371392 DOI: 10.1074/Jbc.Ra119.012127 |
0.344 |
|
| 2020 |
Kurmi K, Haigis MC. Nitrogen Metabolism in Cancer and Immunity. Trends in Cell Biology. 30: 408-424. PMID 32302552 DOI: 10.1016/J.Tcb.2020.02.005 |
0.428 |
|
| 2020 |
Qiao S, Koh SB, Vivekanandan V, Salunke D, Patra KC, Zaganjor E, Ross K, Mizukami Y, Jeanfavre S, Chen A, Mino-Kenudson M, Ramaswamy S, Clish C, Haigis M, Bardeesy N, et al. REDD1 loss reprograms lipid metabolism to drive progression of mutant tumors. Genes & Development. PMID 32273287 DOI: 10.1101/Gad.335166.119 |
0.739 |
|
| 2020 |
Haigis M. Metabolic Competition in the Tumor Microenvironment The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00153 |
0.336 |
|
| 2019 |
Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W. Leveraging insights into cancer metabolism-a symposium report. Annals of the New York Academy of Sciences. PMID 31792987 DOI: 10.1111/Nyas.14274 |
0.433 |
|
| 2019 |
Randall EC, Lopez BGC, Peng S, Regan MS, Abdelmoula WM, Basu SS, Santagata S, Yoon H, Haigis M, Agar JN, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYR. Localized metabolomic gradients in patient-derived xenograft models of glioblastoma. Cancer Research. PMID 31767628 DOI: 10.1158/0008-5472.Can-19-0638 |
0.366 |
|
| 2019 |
Ron-Harel N, Ghergurovich JM, Notarangelo G, LaFleur MW, Tsubosaka Y, Sharpe AH, Rabinowitz JD, Haigis MC. T Cell Activation Depends on Extracellular Alanine. Cell Reports. 28: 3011-3021.e4. PMID 31533027 DOI: 10.1016/J.Celrep.2019.08.034 |
0.37 |
|
| 2019 |
Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PK. Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. Cell Systems. PMID 31078528 DOI: 10.1016/J.Cels.2019.03.009 |
0.373 |
|
| 2019 |
Rossmann MP, Hoi K, Chan V, Perlin JR, Hagedorn EJ, Abraham BJ, Yang S, Sullivan LB, Warren CR, Vyas S, Custo-Creig E, Dorjsuren B, Cowan C, Haigis MC, Young RA, et al. Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis Blood. 134: 152-152. DOI: 10.1182/Blood-2019-126833 |
0.444 |
|
| 2019 |
van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee CS, Oki T, Grace E, Soled HJ, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. The Distinctive Metabolic Environment of the Bone Marrow Niche Drives Leukemia Chemoresistance Blood. 134: 3725-3725. DOI: 10.1182/Blood-2019-124789 |
0.399 |
|
| 2018 |
Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 115: 13347-13352. PMID 30530686 DOI: 10.1073/Pnas.1804149115 |
0.383 |
|
| 2018 |
Ringel AE, Tucker SA, Haigis MC. Chemical and Physiological Features of Mitochondrial Acylation. Molecular Cell. 72: 610-624. PMID 30444998 DOI: 10.1016/J.Molcel.2018.10.023 |
0.393 |
|
| 2018 |
Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti ME. l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Molecular Metabolism. PMID 30190193 DOI: 10.1016/J.Molmet.2018.08.002 |
0.377 |
|
| 2018 |
Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, et al. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. PMID 30022159 DOI: 10.1038/S41586-018-0353-2 |
0.394 |
|
| 2018 |
Spinelli JB, Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nature Cell Biology. 20: 745-754. PMID 29950572 DOI: 10.1038/S41556-018-0124-1 |
0.434 |
|
| 2018 |
Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MC. Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. Proceedings of the National Academy of Sciences of the United States of America. PMID 29915029 DOI: 10.1073/Pnas.1800440115 |
0.721 |
|
| 2018 |
Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, et al. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Molecular Cell. 69: 729-743.e7. PMID 29499131 DOI: 10.1016/J.Molcel.2018.02.005 |
0.739 |
|
| 2018 |
Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, ... Haigis MC, et al. Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Reports. 22: 1945-1955. PMID 29466723 DOI: 10.1016/J.Celrep.2018.01.076 |
0.731 |
|
| 2017 |
Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, Haigis MC. Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass. Science (New York, N.Y.). PMID 29025995 DOI: 10.1126/Science.Aam9305 |
0.408 |
|
| 2017 |
Malone CF, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, Liu LL, Michor F, Haigis M, Macleod KF, Maertens O, Cichowski K. mTOR and HDAC inhibitors converge on the TXNIP/thioredoxin pathway to cause catastrophic oxidative stress and regression of RAS-driven tumors. Cancer Discovery. PMID 28963352 DOI: 10.1158/2159-8290.Cd-17-0177 |
0.383 |
|
| 2017 |
Spinelli JB, Kelley LP, Haigis MC. An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues. Scientific Reports. 7: 10304. PMID 28871132 DOI: 10.1038/S41598-017-09993-6 |
0.331 |
|
| 2017 |
Zaganjor E, Spinelli JB, Haigis MC. Strength in numbers: Phosphofructokinase polymerization prevails in the liver. The Journal of Cell Biology. PMID 28716843 DOI: 10.1083/Jcb.201706005 |
0.694 |
|
| 2017 |
Zaganjor E, Vyas S, Haigis MC. SIRT4 Is a Regulator of Insulin Secretion. Cell Chemical Biology. 24: 656-658. PMID 28644956 DOI: 10.1016/J.Chembiol.2017.06.002 |
0.689 |
|
| 2017 |
van de Ven RA, Santos D, Haigis MC. Mitochondrial Sirtuins and Molecular Mechanisms of Aging. Trends in Molecular Medicine. PMID 28285806 DOI: 10.1016/J.Molmed.2017.02.005 |
0.415 |
|
| 2016 |
Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC. Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Cell. 167: 985-1000.e21. PMID 27881304 DOI: 10.1016/J.Cell.2016.10.016 |
0.715 |
|
| 2016 |
Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nature Immunology. PMID 27695002 DOI: 10.1038/Ni.3578 |
0.355 |
|
| 2016 |
German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, ... ... Haigis MC, et al. PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Molecular Cell. 63: 1006-1020. PMID 27635760 DOI: 10.1016/J.Molcel.2016.08.014 |
0.754 |
|
| 2016 |
Vyas S, Zaganjor E, Haigis MC. Mitochondria and Cancer. Cell. 166: 555-66. PMID 27471965 DOI: 10.1016/J.Cell.2016.07.002 |
0.739 |
|
| 2016 |
Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metabolism. 24: 104-17. PMID 27411012 DOI: 10.1016/J.Cmet.2016.06.007 |
0.416 |
|
| 2015 |
Jeong SM, Haigis MC. Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism. Molecules and Cells. 38: 750-8. PMID 26420294 DOI: 10.14348/Molcells.2015.0167 |
0.429 |
|
| 2015 |
Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH. Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Reports. 12: 163-71. PMID 26146074 DOI: 10.1016/J.Celrep.2015.06.015 |
0.318 |
|
| 2015 |
German NJ, Haigis MC. Sirtuins and the Metabolic Hurdles in Cancer. Current Biology : Cb. 25: R569-83. PMID 26126285 DOI: 10.1016/J.Cub.2015.05.012 |
0.464 |
|
| 2015 |
Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MC. Nuclear respiratory factor 2 induces SIRT3 expression. Aging Cell. PMID 26109058 DOI: 10.1111/Acel.12360 |
0.375 |
|
| 2015 |
Gonzalez Herrera KN, Lee J, Haigis MC. Intersections between mitochondrial sirtuin signaling and tumor cell metabolism. Critical Reviews in Biochemistry and Molecular Biology. 1-14. PMID 25898275 DOI: 10.3109/10409238.2015.1031879 |
0.497 |
|
| 2015 |
Ron-Harel N, Sharpe AH, Haigis MC. Mitochondrial metabolism in T cell activation and senescence: a mini-review. Gerontology. 61: 131-8. PMID 25402204 DOI: 10.1159/000362502 |
0.374 |
|
| 2015 |
Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC. SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 34: 2115-24. PMID 24909164 DOI: 10.1038/Onc.2014.124 |
0.338 |
|
| 2014 |
LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nature Cell Biology. 16: 992-1003, 1-15. PMID 25241037 DOI: 10.1038/Ncb3039 |
0.422 |
|
| 2014 |
Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 10574-9. PMID 25002509 DOI: 10.1073/Pnas.1409844111 |
0.427 |
|
| 2014 |
Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, ... ... Haigis MC, et al. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proceedings of the National Academy of Sciences of the United States of America. 111: 10299-304. PMID 24982195 DOI: 10.1073/Pnas.1404399111 |
0.311 |
|
| 2014 |
Satterstrom FK, Haigis MC. Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter. Methods in Enzymology. 543: 141-63. PMID 24924131 DOI: 10.1016/B978-0-12-801329-8.00007-6 |
0.354 |
|
| 2014 |
Jeong SM, Lee A, Lee J, Haigis MC. SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. The Journal of Biological Chemistry. 289: 4135-44. PMID 24368766 DOI: 10.1074/Jbc.M113.525949 |
0.471 |
|
| 2014 |
LeBleu VS, O'Connell JT, Herrera KNG, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Chinen LTD, Rocha RM, Asara JM, Kalluri R. Erratum: Corrigendum: PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis Nature Cell Biology. 16: 1125-1125. DOI: 10.1038/Ncb3056 |
0.389 |
|
| 2013 |
Bause AS, Matsui MS, Haigis MC. The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation. The Journal of Biological Chemistry. 288: 36484-91. PMID 24194516 DOI: 10.1074/Jbc.M113.472324 |
0.362 |
|
| 2013 |
Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA, Haigis MC. SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Molecular and Cellular Biology. 33: 4552-61. PMID 24043310 DOI: 10.1128/Mcb.00087-13 |
0.436 |
|
| 2013 |
Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, ... ... Haigis MC, et al. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Molecular Cell. 50: 686-98. PMID 23746352 DOI: 10.1016/J.Molcel.2013.05.012 |
0.411 |
|
| 2013 |
Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153: 840-54. PMID 23663782 DOI: 10.1016/J.Cell.2013.04.023 |
0.497 |
|
| 2013 |
Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, ... ... Haigis MC, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 23: 450-63. PMID 23562301 DOI: 10.1016/J.Ccr.2013.02.024 |
0.401 |
|
| 2013 |
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496: 101-5. PMID 23535601 DOI: 10.1038/Nature12040 |
0.47 |
|
| 2013 |
Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone C. A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cellular and Molecular Life Sciences : Cmls. 70: 2015-29. PMID 23283301 DOI: 10.1007/S00018-012-1244-6 |
0.405 |
|
| 2013 |
Bause AS, Haigis MC. SIRT3 regulation of mitochondrial oxidative stress. Experimental Gerontology. 48: 634-9. PMID 22964489 DOI: 10.1016/J.Exger.2012.08.007 |
0.401 |
|
| 2013 |
Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, et al. Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Nature. 499: 504-504. DOI: 10.1038/Nature12317 |
0.403 |
|
| 2012 |
Sebastián C, Satterstrom FK, Haigis MC, Mostoslavsky R. From sirtuin biology to human diseases: an update. The Journal of Biological Chemistry. 287: 42444-52. PMID 23086954 DOI: 10.1074/Jbc.R112.402768 |
0.356 |
|
| 2012 |
Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, ... Haigis MC, et al. A metabolic prosurvival role for PML in breast cancer. The Journal of Clinical Investigation. 122: 3088-100. PMID 22886304 DOI: 10.1172/Jci62129 |
0.434 |
|
| 2012 |
Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, ... Haigis MC, et al. Acetylation-dependent regulation of Skp2 function. Cell. 150: 179-93. PMID 22770219 DOI: 10.1016/J.Cell.2012.05.038 |
0.387 |
|
| 2012 |
Finley LW, Haigis MC. Metabolic regulation by SIRT3: implications for tumorigenesis. Trends in Molecular Medicine. 18: 516-23. PMID 22749020 DOI: 10.1016/J.Molmed.2012.05.004 |
0.499 |
|
| 2012 |
Haigis MC, Deng CX, Finley LW, Kim HS, Gius D. SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Research. 72: 2468-72. PMID 22589271 DOI: 10.1158/0008-5472.Can-11-3633 |
0.41 |
|
| 2012 |
Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 10: 515-9. PMID 22560075 DOI: 10.1016/J.Stem.2012.04.002 |
0.336 |
|
| 2012 |
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 149: 49-62. PMID 22401813 DOI: 10.1016/J.Cell.2012.02.030 |
0.448 |
|
| 2012 |
Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. Proceedings of the National Academy of Sciences of the United States of America. 109: 2931-6. PMID 22308395 DOI: 10.1073/Pnas.1115813109 |
0.355 |
|
| 2012 |
Satterstrom FK, Swindell WR, Bulyk ML, Haigis MC. Bioinformatic and molecular investigation of Sirt3 expression Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-P40 |
0.492 |
|
| 2012 |
Lee J, Ng MR, Sinkevicius KW, Kim CF, Danuser G, Brugge JS, Haigis MC. Altered metabolic requirements in cancer cell migration and metastasis Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-P32 |
0.44 |
|
| 2012 |
Jeong SM, Haigis MC. Cellular metabolic response to DNA damage Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-P24 |
0.356 |
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| 2012 |
Gonzalez Herrera KN, Finley LW, Haigis MC. The role of SIRT3 in regulating cancer cell metabolism Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-P18 |
0.495 |
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| 2012 |
Haigis M. Regulation of metabolism by sirtuins Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O9 |
0.483 |
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| 2012 |
Srivastava S, Gonzalez Herrera KN, Proacccio V, Wallace DC, Haigis MC. Low level of MtDNA mutation promotes mitochondrial bioenergetics and oxidative metabolism via retrograde signaling Mitochondrion. 12: 553. DOI: 10.1016/J.Mito.2012.07.009 |
0.387 |
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| 2011 |
De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 20: 400-13. PMID 21907929 DOI: 10.1016/J.Ccr.2011.08.014 |
0.348 |
|
| 2011 |
Srivastava S, Haigis MC. Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases. Current Pharmaceutical Design. 17: 3418-33. PMID 21902666 DOI: 10.2174/138161211798072526 |
0.311 |
|
| 2011 |
Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, Haigis MC. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. Plos One. 6: e23295. PMID 21858060 DOI: 10.1371/Journal.Pone.0023295 |
0.381 |
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| 2011 |
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, et al. Pancreatic cancers require autophagy for tumor growth. Genes & Development. 25: 717-29. PMID 21406549 DOI: 10.1101/Gad.2016111 |
0.397 |
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| 2011 |
Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell. 19: 416-28. PMID 21397863 DOI: 10.1016/J.Ccr.2011.02.014 |
0.467 |
|
| 2010 |
Haigis MC, Yankner BA. The aging stress response. Molecular Cell. 40: 333-44. PMID 20965426 DOI: 10.1016/J.Molcel.2010.10.002 |
0.335 |
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| 2010 |
Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends in Biochemical Sciences. 35: 669-75. PMID 20863707 DOI: 10.1016/J.Tibs.2010.07.003 |
0.446 |
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| 2010 |
Lomb DJ, Laurent G, Haigis MC. Sirtuins regulate key aspects of lipid metabolism. Biochimica Et Biophysica Acta. 1804: 1652-7. PMID 19962456 DOI: 10.1016/J.Bbapap.2009.11.021 |
0.419 |
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| 2009 |
Finley LW, Haigis MC. The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Research Reviews. 8: 173-88. PMID 19491041 DOI: 10.1016/J.Arr.2009.03.003 |
0.376 |
|
| 2009 |
Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 137: 560-70. PMID 19410549 DOI: 10.1016/J.Cell.2009.02.026 |
0.438 |
|
| 2007 |
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/Mcb.01636-07 |
0.418 |
|
| 2006 |
Haigis MC, Guarente LP. Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes & Development. 20: 2913-21. PMID 17079682 DOI: 10.1101/Gad.1467506 |
0.352 |
|
| 2006 |
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 126: 941-54. PMID 16959573 DOI: 10.1016/J.Cell.2006.06.057 |
0.395 |
|
| 2005 |
Dickson KA, Haigis MC, Raines RT. Ribonuclease inhibitor: structure and function. Progress in Nucleic Acid Research and Molecular Biology. 80: 349-74. PMID 16164979 DOI: 10.1016/S0079-6603(05)80009-1 |
0.706 |
|
| 2005 |
Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. SIRT1 shows no substrate specificity in vitro Journal of Biological Chemistry. 280: 9780-9785. PMID 15640142 DOI: 10.1074/Jbc.M414080200 |
0.377 |
|
| 2004 |
Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. The Biochemical Journal. 383: 439-46. PMID 15285718 DOI: 10.1042/Bj20041081 |
0.362 |
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| 2003 |
Blander G, De Oliveira RM, Conboy CM, Haigis M, Guarente L. Superoxide dismutase 1 knock-down induces senescence in human fibroblasts Journal of Biological Chemistry. 278: 38966-38969. PMID 12871978 DOI: 10.1074/Jbc.M307146200 |
0.386 |
|
| 2003 |
Haigis MC, Kurten EL, Raines RT. Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Research. 31: 1024-32. PMID 12560499 DOI: 10.1093/Nar/Gkg163 |
0.512 |
|
| 2003 |
Haigis MC, Raines RT. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. Journal of Cell Science. 116: 313-24. PMID 12482917 DOI: 10.1242/Jcs.00214 |
0.518 |
|
| 2002 |
Abel RL, Haigis MC, Park C, Raines RT. Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Analytical Biochemistry. 306: 100-7. PMID 12069420 DOI: 10.1006/Abio.2002.5678 |
0.565 |
|
| 2002 |
Haigis MC, Haag ES, Raines RT. Evolution of ribonuclease inhibitor by exon duplication. Molecular Biology and Evolution. 19: 959-63. PMID 12032252 DOI: 10.1093/Oxfordjournals.Molbev.A004153 |
0.47 |
|
| 2002 |
Haigis MC, Kurten EL, Abel RL, Raines RT. KFERQ sequence in ribonuclease A-mediated cytotoxicity. The Journal of Biological Chemistry. 277: 11576-81. PMID 11801605 DOI: 10.1074/Jbc.M112227200 |
0.53 |
|
| 2002 |
Umezawa N, Gelman MA, Haigis MC, Raines RT, Gellman SH. Translocation of a beta-peptide across cell membranes. Journal of the American Chemical Society. 124: 368-9. PMID 11792194 DOI: 10.1021/Ja017283V |
0.434 |
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