Leah Edelstein-Keshet - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Mathematics, Biostatistics Biology

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Buttenschön A, Edelstein-Keshet L. Cell Repolarization: A Bifurcation Study of Spatio-Temporal Perturbations of Polar Cells. Bulletin of Mathematical Biology. 84: 114. PMID 36058957 DOI: 10.1007/s11538-022-01053-z  0.34
2022 Mukhtar N, Cytrynbaum EN, Edelstein-Keshet L. A multiscale computational model of YAP signaling in epithelial fingering behavior. Biophysical Journal. 121: 1940-1948. PMID 35422412 DOI: 10.1016/j.bpj.2022.04.010  0.327
2021 Rens E, Edelstein-Keshet L. Cellular tango: How extracellular matrix adhesion choreographs Rac-Rho signaling and cell movement. Physical Biology. PMID 34544056 DOI: 10.1088/1478-3975/ac2888  0.338
2021 Liu Y, Rens EG, Edelstein-Keshet L. Spots, stripes, and spiral waves in models for static and motile cells : GTPase patterns in cells. Journal of Mathematical Biology. 82: 28. PMID 33660145 DOI: 10.1007/s00285-021-01550-0  0.348
2020 Buttenschön A, Edelstein-Keshet L. Bridging from single to collective cell migration: A review of models and links to experiments. Plos Computational Biology. 16: e1008411. PMID 33301528 DOI: 10.1371/journal.pcbi.1008411  0.302
2020 Mulberry N, Edelstein-Keshet L. Self-organized multicellular structures from simple cell signaling: a computational model. Physical Biology. 17: 066003. PMID 33210618 DOI: 10.1088/1478-3975/Abb2Dc  0.412
2020 Buttenschön A, Liu Y, Edelstein-Keshet L. Cell Size, Mechanical Tension, and GTPase Signaling in the Single Cell. Bulletin of Mathematical Biology. 82: 28. PMID 32016583 DOI: 10.1007/S11538-020-00702-5  0.462
2019 Rens EG, Edelstein-Keshet L. From energy to cellular forces in the Cellular Potts Model: An algorithmic approach. Plos Computational Biology. 15: e1007459. PMID 31825952 DOI: 10.1371/Journal.Pcbi.1007459  0.353
2019 Buttenschön A, Edelstein-Keshet L. Correlated random walks inside a cell: actin branching and microtubule dynamics. Journal of Mathematical Biology. PMID 31422441 DOI: 10.1007/S00285-019-01416-6  0.408
2018 Cusseddu D, Edelstein-Keshet L, Mackenzie JA, Portet S, Madzvamuse A. A coupled bulk-surface model for cell polarisation. Journal of Theoretical Biology. 481: 119-135. PMID 30205095 DOI: 10.1016/J.Jtbi.2018.09.008  0.41
2018 Zmurchok C, Bhaskar D, Edelstein-Keshet L. Coupling mechanical tension and GTPase signaling to generate cell and tissue dynamics. Physical Biology. PMID 29473547 DOI: 10.1088/1478-3975/Aab1C0  0.416
2018 Merchant B, Edelstein-Keshet L, Feng JJ. A Rho-GTPase based model explains spontaneous collective migration of neural crest cell clusters. Developmental Biology. PMID 29366821 DOI: 10.1016/J.Ydbio.2018.01.013  0.409
2017 Rappel WJ, Edelstein-Keshet L. Mechanisms of Cell Polarization. Current Opinion in Systems Biology. 3: 43-53. PMID 29038793 DOI: 10.1016/J.Coisb.2017.03.005  0.353
2017 Zmurchok C, Small T, Ward MJ, Edelstein-Keshet L. Application of Quasi-Steady-State Methods to Nonlinear Models of Intracellular Transport by Molecular Motors. Bulletin of Mathematical Biology. PMID 28707220 DOI: 10.1007/S11538-017-0314-1  0.336
2017 Park J, Holmes WR, Lee SH, Kim HN, Kim DH, Kwak MK, Wang CJ, Edelstein-Keshet L, Levchenko A. Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations. Proceedings of the National Academy of Sciences of the United States of America. PMID 28655842 DOI: 10.1073/Pnas.1700054114  0.423
2017 Holmes WR, Park J, Levchenko A, Edelstein-Keshet L. A mathematical model coupling polarity signaling to cell adhesion explains diverse cell migration patterns. Plos Computational Biology. 13: e1005524. PMID 28472054 DOI: 10.1371/Journal.Pcbi.1005524  0.406
2017 Knutsdottir H, Zmurchok C, Bhaskar D, Palsson E, Dalle Nogare D, Chitnis A, Edelstein-Keshet L. Polarization and migration in the zebrafish posterior lateral line system. Plos Computational Biology. 13: e1005451. PMID 28369079 DOI: 10.1371/Journal.Pcbi.1005451  0.396
2017 Edelstein-Keshet L. Models for Cancer Cell Motility: Regulation and Signaling Biophysical Journal. 112: 38a. DOI: 10.1016/J.Bpj.2016.11.244  0.341
2016 Holmes WR, Golding AE, Bement WM, Edelstein-Keshet L. A mathematical model of GTPase pattern formation during single-cell wound repair. Interface Focus. 6: 20160032. PMID 27708759 DOI: 10.1098/Rsfs.2016.0032  0.419
2016 Holmes WR, Edelstein-Keshet L. Analysis of a minimal Rho-GTPase circuit regulating cell shape. Physical Biology. 13: 046001. PMID 27434017 DOI: 10.1088/1478-3975/13/4/046001  0.445
2016 Edelstein-Keshet L. Flipping the Rac-Rho Switch in Cell Motility. Cell Systems. 2: 10-12. PMID 27136684 DOI: 10.1016/J.Cels.2016.01.005  0.328
2015 Holmes WR, Liao L, Bement W, Edelstein-Keshet L. Modeling the roles of protein kinase Cβ and η in single-cell wound repair. Molecular Biology of the Cell. 26: 4100-8. PMID 26310444 DOI: 10.1091/Mbc.E15-06-0383  0.352
2015 Dauvergne D, Edelstein-Keshet L. Application of quasi-steady state methods to molecular motor transport on microtubules in fungal hyphae. Journal of Theoretical Biology. 379: 47-58. PMID 25960428 DOI: 10.1016/J.Jtbi.2015.04.033  0.319
2015 Holmes WR, Mata MA, Edelstein-Keshet L. Local perturbation analysis: a computational tool for biophysical reaction-diffusion models. Biophysical Journal. 108: 230-6. PMID 25606671 DOI: 10.1016/J.Bpj.2014.11.3457  0.386
2014 Gou J, Edelstein-Keshet L, Allard J. Mathematical model with spatially uniform regulation explains long-range bidirectional transport of early endosomes in fungal hyphae. Molecular Biology of the Cell. 25: 2408-15. PMID 24943842 DOI: 10.1091/Mbc.E14-03-0826  0.364
2014 Knútsdóttir H, Pálsson E, Edelstein-Keshet L. Mathematical model of macrophage-facilitated breast cancer cells invasion. Journal of Theoretical Biology. 357: 184-99. PMID 24810842 DOI: 10.1016/J.Jtbi.2014.04.031  0.41
2013 Tania N, Condeelis J, Edelstein-Keshet L. Modeling the synergy of cofilin and Arp2/3 in lamellipodial protrusive activity. Biophysical Journal. 105: 1946-55. PMID 24209839 DOI: 10.1016/J.Bpj.2013.09.013  0.42
2013 Edelstein-Keshet L, Holmes WR, Zajac M, Dutot M. From simple to detailed models for cell polarization. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20130003. PMID 24062577 DOI: 10.1098/Rstb.2013.0003  0.442
2013 Mata MA, Dutot M, Edelstein-Keshet L, Holmes WR. A model for intracellular actin waves explored by nonlinear local perturbation analysis. Journal of Theoretical Biology. 334: 149-61. PMID 23831272 DOI: 10.1016/J.Jtbi.2013.06.020  0.38
2013 Simon CM, Vaughan EM, Bement WM, Edelstein-Keshet L. Pattern formation of Rho GTPases in single cell wound healing. Molecular Biology of the Cell. 24: 421-32. PMID 23264464 DOI: 10.1091/Mbc.E12-08-0634  0.403
2012 Holmes WR, Edelstein-Keshet L. A comparison of computational models for eukaryotic cell shape and motility. Plos Computational Biology. 8: e1002793. PMID 23300403 DOI: 10.1371/Journal.Pcbi.1002793  0.408
2012 Lin B, Holmes WR, Wang CJ, Ueno T, Harwell A, Edelstein-Keshet L, Inoue T, Levchenko A. Synthetic spatially graded Rac activation drives cell polarization and movement. Proceedings of the National Academy of Sciences of the United States of America. 109: E3668-77. PMID 23185021 DOI: 10.1073/Pnas.1210295109  0.399
2012 Walther GR, Marée AF, Edelstein-Keshet L, Grieneisen VA. Deterministic versus stochastic cell polarisation through wave-pinning. Bulletin of Mathematical Biology. 74: 2570-99. PMID 22956290 DOI: 10.1007/S11538-012-9766-5  0.42
2012 Topaz CM, D'Orsogna MR, Edelstein-Keshet L, Bernoff AJ. Locust dynamics: behavioral phase change and swarming. Plos Computational Biology. 8: e1002642. PMID 22916003 DOI: 10.1371/Journal.Pcbi.1002642  0.324
2012 Holmes WR, Carlsson AE, Edelstein-Keshet L. Regimes of wave type patterning driven by refractory actin feedback: transition from static polarization to dynamic wave behaviour. Physical Biology. 9: 046005. PMID 22785332 DOI: 10.1088/1478-3975/9/4/046005  0.408
2012 Tania N, Vanderlei B, Heath JP, Edelstein-Keshet L. Role of social interactions in dynamic patterns of resource patches and forager aggregation. Proceedings of the National Academy of Sciences of the United States of America. 109: 11228-33. PMID 22745167 DOI: 10.1073/Pnas.1201739109  0.311
2012 Holmes WR, Lin B, Levchenko A, Edelstein-Keshet L. Modelling cell polarization driven by synthetic spatially graded Rac activation. Plos Computational Biology. 8: e1002366. PMID 22737059 DOI: 10.1371/Journal.Pcbi.1002366  0.445
2012 Marée AF, Grieneisen VA, Edelstein-Keshet L. How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility. Plos Computational Biology. 8: e1002402. PMID 22396633 DOI: 10.1371/Journal.Pcbi.1002402  0.424
2012 Holmes WR, Edelstein-Keshet L. A Biochemical Model for Sub-Cellular Waves of Actin Activity Biophysical Journal. 102: 375a-376a. DOI: 10.1016/J.Bpj.2011.11.2051  0.33
2012 Edelstein-Keshet L. Exploring Feedbacks Between Small GTPases, Phosphoinositides, and the Actin Cytoskeleton Biophysical Journal. 102: 348a. DOI: 10.1016/J.Bpj.2011.11.1908  0.36
2011 Vanderlei B, Feng JJ, Edelstein-Keshet L. A computational model of cell polarization and motility coupling mechanics and biochemistry. Multiscale Modeling & Simulation : a Siam Interdisciplinary Journal. 9: 1420-1443. PMID 22904684 DOI: 10.1137/100815335  0.376
2011 Mori Y, Jilkine A, Edelstein-Keshet L. ASYMPTOTIC AND BIFURCATION ANALYSIS OF WAVE-PINNING IN A REACTION-DIFFUSION MODEL FOR CELL POLARIZATION. Siam Journal On Applied Mathematics. 71: 1401-1427. PMID 22171122 DOI: 10.1137/10079118X  0.343
2011 Jilkine A, Edelstein-Keshet L. A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues. Plos Computational Biology. 7: e1001121. PMID 21552548 DOI: 10.1371/Journal.Pcbi.1001121  0.413
2011 Tania N, Prosk E, Condeelis J, Edelstein-Keshet L. A temporal model of cofilin regulation and the early peak of actin barbed ends in invasive tumor cells. Biophysical Journal. 100: 1883-92. PMID 21504724 DOI: 10.1016/J.Bpj.2011.02.036  0.407
2011 Mogilner A, Edelstein-Keshet L, Bloom K. Guidelines for publishing papers containing theory and modeling Molecular Biology of the Cell. 22: 907-908. DOI: 10.1091/Mbc.E11-01-0088  0.389
2010 Khadra A, Tsai S, Santamaria P, Edelstein-Keshet L. On how monospecific memory-like autoregulatory CD8+ T cells can blunt diabetogenic autoimmunity: a computational approach. Journal of Immunology (Baltimore, Md. : 1950). 185: 5962-72. PMID 20962260 DOI: 10.4049/Jimmunol.1001306  0.304
2010 Green JE, Waters SL, Whiteley JP, Edelstein-Keshet L, Shakesheff KM, Byrne HM. Non-local models for the formation of hepatocyte-stellate cell aggregates. Journal of Theoretical Biology. 267: 106-20. PMID 20709085 DOI: 10.1016/J.Jtbi.2010.08.013  0.405
2010 Lukeman R, Li YX, Edelstein-Keshet L. Inferring individual rules from collective behavior. Proceedings of the National Academy of Sciences of the United States of America. 107: 12576-80. PMID 20616032 DOI: 10.1073/Pnas.1001763107  0.356
2010 Khadra A, Santamaria P, Edelstein-Keshet L. The pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach. International Immunology. 22: 571-82. PMID 20497954 DOI: 10.1093/Intimm/Dxq041  0.318
2009 Khadra A, Santamaria P, Edelstein-Keshet L. The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation. Journal of Theoretical Biology. 256: 126-41. PMID 18950644 DOI: 10.1016/J.Jtbi.2008.09.019  0.328
2009 Lukeman R, Li YX, Edelstein-Keshet L. A conceptual model for milling formations in biological aggregates. Bulletin of Mathematical Biology. 71: 352-82. PMID 18855072 DOI: 10.1007/S11538-008-9365-7  0.383
2008 Mori Y, Jilkine A, Edelstein-Keshet L. Wave-pinning and cell polarity from a bistable reaction-diffusion system. Biophysical Journal. 94: 3684-97. PMID 18212014 DOI: 10.1529/Biophysj.107.120824  0.395
2007 Jilkine A, Marée AF, Edelstein-Keshet L. Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk. Bulletin of Mathematical Biology. 69: 1943-78. PMID 17457653 DOI: 10.1007/S11538-007-9200-6  0.413
2007 Gutenkunst R, Newlands N, Lutcavage M, Edelstein-Keshet L. Inferring resource distributions from Atlantic bluefin tuna movements: an analysis based on net displacement and length of track. Journal of Theoretical Biology. 245: 243-57. PMID 17140603 DOI: 10.1016/J.Jtbi.2006.10.014  0.312
2007 Dawes AT, Edelstein-Keshet L. Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell. Biophysical Journal. 92: 744-68. PMID 17098793 DOI: 10.1529/Biophysj.106.090514  0.447
2006 Marée AF, Jilkine A, Dawes A, Grieneisen VA, Edelstein-Keshet L. Polarization and movement of keratocytes: a multiscale modelling approach. Bulletin of Mathematical Biology. 68: 1169-211. PMID 16794915 DOI: 10.1007/S11538-006-9131-7  0.458
2006 Marée AF, Santamaria P, Edelstein-Keshet L. Modeling competition among autoreactive CD8+ T cells in autoimmune diabetes: implications for antigen-specific therapy. International Immunology. 18: 1067-77. PMID 16728432 DOI: 10.1093/Intimm/Dxl040  0.307
2006 Marée AF, Kublik R, Finegood DT, Edelstein-Keshet L. Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease? Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 364: 1267-82. PMID 16608707 DOI: 10.1098/Rsta.2006.1769  0.303
2006 Dawes AT, Bard Ermentrout G, Cytrynbaum EN, Edelstein-Keshet L. Actin filament branching and protrusion velocity in a simple 1D model of a motile cell. Journal of Theoretical Biology. 242: 265-79. PMID 16600307 DOI: 10.1016/J.Jtbi.2006.02.017  0.422
2003 Luca M, Chavez-Ross A, Edelstein-Keshet L, Mogilner A. Chemotactic signaling, microglia, and Alzheimer's disease senile plaques: is there a connection? Bulletin of Mathematical Biology. 65: 693-730. PMID 12875339 DOI: 10.1016/S0092-8240(03)00030-2  0.682
2002 Mogilner A, Edelstein-Keshet L. Regulation of actin dynamics in rapidly moving cells: a quantitative analysis. Biophysical Journal. 83: 1237-58. PMID 12202352 DOI: 10.1016/S0006-3495(02)73897-6  0.439
2002 Edelstein-keshet L, Spiros A. Exploring the formation of Alzheimer's disease senile plaques in silico. Journal of Theoretical Biology. 216: 301-26. PMID 12183120 DOI: 10.1006/Jtbi.2002.2540  0.367
2001 Edelstein-Keshet L, Ermentrout GB. A model for actin-filament length distribution in a lamellipod. Journal of Mathematical Biology. 43: 325-55. PMID 12120872 DOI: 10.1007/S002850100102  0.387
2001 Edelstein-Keshet L, Israel A, Lansdorp P. Modelling perspectives on aging: Can mathematics help us stay young? Journal of Theoretical Biology. 213: 509-525. PMID 11742522 DOI: 10.1006/Jtbi.2001.2429  0.323
1999 Mogilner A, Edelstein-Keshet L. A non-local model for a swarm Journal of Mathematical Biology. 38: 534-570. DOI: 10.1007/S002850050158  0.341
1998 Edelstein-Keshet L. A mathematical approach to cytoskeletal assembly European Biophysics Journal. 27: 521-531. PMID 9760733 DOI: 10.1007/S002490050162  0.424
1998 Ermentrout GB, Edelstein-Keshet L. Models for the length distributions of actin filaments: II. Polymerization and fragmentation by gelsolin acting together. Bulletin of Mathematical Biology. 60: 477-503. PMID 9608854 DOI: 10.1006/Bulm.1997.0012  0.368
1998 Edelstein-Keshet L, Ermentrout GB. Models for the length distributions of actin filaments: I. Simple polymerization and fragmentation. Bulletin of Mathematical Biology. 60: 449-75. PMID 9608853 DOI: 10.1006/Bulm.1997.0011  0.378
1998 Spiros A, Edelstein-Keshet L. Testing a model for the dynamics of actin structures with biological parameter values Bulletin of Mathematical Biology. 60: 275-305. PMID 9559578 DOI: 10.1006/Bulm.1997.0022  0.38
1998 Edelstein-Keshet L, Watmough J, Grunbaum D. Do travelling band solutions describe cohesive swarms? An investigation for migratory locusts Journal of Mathematical Biology. 36: 515-549. DOI: 10.1007/S002850050112  0.335
1996 Mogilner A, Edelstein-Keshet L, Ermentrout GB. Selecting a common direction. II. Peak-like solutions representing total alignment of cell clusters. Journal of Mathematical Biology. 34: 811-42. PMID 8858852 DOI: 10.1007/Bf01834821  0.317
1996 Mogilner A, Edelstein-Keshet L. Spatio-angular order in populations of self-aligning objects: Formation of oriented patches Physica D: Nonlinear Phenomena. 89: 346-367. DOI: 10.1016/0167-2789(95)00207-3  0.382
1996 Mogilner A, Edelstein-Keshet L, Bard Ermentrout G. Selecting a common direction Journal of Mathematical Biology. 34: 811-842. DOI: 10.1007/Bf00298646  0.388
1995 Edelstein-Keshet L, Watmough J, Ermentrout GB. Trail following in ants: individual properties determine population behaviour Behavioral Ecology and Sociobiology. 36: 119-133. DOI: 10.1007/Bf00170717  0.321
1995 Watmough J, Edelstein-Keshet L. A one-dimensional model of trail propagation by army ants Journal of Mathematical Biology. 33: 459-476. DOI: 10.1007/Bf00163038  0.321
1995 Watmough J, Edelstein-Keshet L. Modelling the Formation of Trail Networks by Foraging Ants Journal of Theoretical Biology. 176: 357-371. DOI: 10.1006/Jtbi.1995.0205  0.312
1994 Civelekoglu G, Edelstein-Keshet L. Modelling the dynamics of F-actin in the cell Bulletin of Mathematical Biology. 56: 587-616. PMID 8054888 DOI: 10.1016/S0092-8240(05)80305-2  0.343
1994 Edelstein-Keshet L. Simple models for trail-following behaviour; Trunk trails versus individual foragers Journal of Mathematical Biology. 32: 303-328. DOI: 10.1007/Bf00160163  0.32
1993 Ermentrout GB, Edelstein-Keshet L. Cellular automata approaches to biological modeling. Journal of Theoretical Biology. 160: 97-133. PMID 8474249 DOI: 10.1006/Jtbi.1993.1007  0.325
1990 Edelstein-Keshet L, Ermentrout GB. Contact response of cells can mediate morphogenetic pattern formation. Differentiation; Research in Biological Diversity. 45: 147-59. PMID 2090517 DOI: 10.1111/J.1432-0436.1990.Tb00468.X  0.392
1989 Edelstein-Keshet L, Ermentrout B. Models for Branching Networks in Two Dimensions Siam Journal On Applied Mathematics. 49: 1136-1157. DOI: 10.1137/0149068  0.329
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