Craig A. Simmons - Publications

Affiliations: 
Institute of Biomaterials and Biomedical Engineering University of Toronto, Toronto, ON, Canada 
Area:
Biomedical Engineering, Cell Biology

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Beca B, Sun Y, Wong E, Moraes C, Simmons CA. Dynamic bioreactors with integrated microfabricated devices for mechanobiological screening. Tissue Engineering. Part C, Methods. PMID 31337285 DOI: 10.1089/ten.TEC.2019.0121  1
2019 Hadipour-Lakmehsari S, Driouchi A, Lee SH, Kuzmanov U, Callaghan NI, Heximer SP, Simmons CA, Yip CM, Gramolini AO. Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM. Scientific Reports. 9: 7867. PMID 31133706 DOI: 10.1038/s41598-019-44331-y  0.44
2019 Callaghan NI, Hadipour-Lakmehsari S, Lee SH, Gramolini AO, Simmons CA. Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development . Apl Bioengineering. 3: 011501. PMID 31069331 DOI: 10.1063/1.5055873  0.44
2018 Zhang X, Simmons CA, Santerre JP. Alterations of MEK1/2-ERK1/2, IFNγ and Smad2/3 associated Signalling pathways during cryopreservation of ASCs affect their differentiation towards VSMC-like cells. Stem Cell Research. 32: 115-125. PMID 30273905 DOI: 10.1016/j.scr.2018.09.005  0.36
2018 Wang L, Dou W, Malhi M, Zhu M, Liu H, Plakhotnik J, Xu Z, Zhao Q, Chen J, Chen S, Hamilton R, Simmons CA, Maynes JT, Sun Y. A Micro Device Platform for Continuous Measurement of Contractility, Beating Rate, and Beating Rhythm of hiPSC-Cardiomyocytes inside a Controlled Incubator Environment. Acs Applied Materials & Interfaces. PMID 29874032 DOI: 10.1021/acsami.8b05407  1
2018 Wang X, Liu H, Zhu M, Cao C, Xu Z, Tsatskis Y, Lau K, Kuok C, Filleter T, McNeill H, Simmons CA, Hopyan S, Sun Y. Mechanical stability of the cell nucleus: roles played by the cytoskeleton in nuclear deformation and strain recovery. Journal of Cell Science. PMID 29777038 DOI: 10.1242/jcs.209627  1
2018 Zhong A, Mirzaei Z, Simmons CA. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to-Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. PMID 29761409 DOI: 10.1007/s13239-018-0363-0  0.64
2018 Liu H, MacQueen LA, Usprech JF, Maleki H, Sider KL, Doyle MG, Sun Y, Simmons CA. Microdevice arrays with strain sensors for 3D mechanical stimulation and monitoring of engineered tissues. Biomaterials. 172: 30-40. PMID 29715593 DOI: 10.1016/j.biomaterials.2018.04.041  1
2017 Blaser MC, Wei K, Adams RL, Zhou YQ, Caruso LL, Mirzaei Z, Lam A, Tam RK, Zhang H, Heximer SP, Henkelman M, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. PMID 29273600 DOI: 10.1161/CIRCRESAHA.117.311194  0.68
2017 Zhang X, Bendeck MP, Simmons CA, Santerre JP. Deriving vascular smooth muscle cells from mesenchymal stromal cells: Evolving differentiation strategies and current understanding of their mechanisms. Biomaterials. 145: 9-22. PMID 28843066 DOI: 10.1016/j.biomaterials.2017.08.028  0.36
2017 Wen J, Tao H, Lau K, Liu H, Simmons CA, Sun Y, Hopyan S. Cell and Tissue Scale Forces Coregulate Fgfr2-Dependent Tetrads and Rosettes in the Mouse Embryo. Biophysical Journal. 112: 2209-2218. PMID 28538157 DOI: 10.1016/j.bpj.2017.04.024  1
2017 Usprech J, Romero DA, Amon CH, Simmons CA. Combinatorial screening of 3D biomaterial properties that promote myofibrogenesis for mesenchymal stromal cell-based heart valve tissue engineering. Acta Biomaterialia. PMID 28532900 DOI: 10.1016/j.actbio.2017.05.044  0.84
2017 Zhang X, Battiston KG, Labow RS, Simmons CA, Santerre JP. Generating favourable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment. Acta Biomaterialia. PMID 28242454 DOI: 10.1016/j.actbio.2017.02.041  0.36
2016 Loai S, Haedicke I, Mirzaei Z, Simmons CA, Zhang XA, Cheng HM. Positive-contrast cellular MRI of embryonic stem cells for tissue regeneration using a highly efficient T1 MRI contrast agent. Journal of Magnetic Resonance Imaging : Jmri. PMID 27185221 DOI: 10.1002/jmri.25299  1
2016 Usprech J, Chen WL, Simmons CA. Heart valve regeneration: the need for systems approaches. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 26862013 DOI: 10.1002/wsbm.1329  1
2016 Liu H, Simmons CA, Sun Y. A microfabricated platform with on-chip strain sensing and hydrogel arrays for 3D mechanical stimulation of cells Proceedings of the Ieee International Conference On Micro Electro Mechanical Systems (Mems). 2016: 267-270. DOI: 10.1109/MEMSYS.2016.7421611  1
2015 Liu H, Usprech J, Sun Y, Simmons CA. A microfabricated platform with hydrogel arrays for 3D mechanical stimulation of cells. Acta Biomaterialia. PMID 26646540 DOI: 10.1016/j.actbio.2015.11.054  0.84
2015 Nejad SP, Blaser MC, Paul Santerre J, Caldarone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing? Advanced Drug Delivery Reviews. PMID 26555371 DOI: 10.1016/j.addr.2015.11.003  1
2015 Ireland RG, Simmons CA. Human Pluripotent Stem Cell Mechanobiology: Manipulating the Biophysical Microenvironment for Regenerative Medicine and Tissue Engineering Applications. Stem Cells (Dayton, Ohio). PMID 26189759 DOI: 10.1002/stem.2105  1
2015 Battiston KG, Labow RS, Simmons CA, Santerre JP. Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation. Acta Biomaterialia. PMID 26093069 DOI: 10.1016/j.actbio.2015.05.038  1
2015 Battiston KG, Ouyang B, Honarparvar E, Qian J, Labow RS, Simmons CA, Santerre JP. Interaction of a block-co-polymeric biomaterial with immunoglobulin G modulates human monocytes towards a non-inflammatory phenotype. Acta Biomaterialia. PMID 26074158 DOI: 10.1016/j.actbio.2015.06.003  1
2015 Plaza GR, Uyeda TQ, Mirzaei Z, Simmons CA. Study of the influence of actin-binding proteins using linear analyses of cell deformability. Soft Matter. 11: 5435-46. PMID 26059185 DOI: 10.1039/c5sm00125k  1
2015 Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo R, Grande-Allen KJ, Simmons CA, Griffith B, Falahatpisheh A, Goergen CJ, Mofrad MR, Baaijens F, Little SH, Canic S. Emerging trends in heart valve engineering: Part I. Solutions for future. Annals of Biomedical Engineering. 43: 833-43. PMID 25488074 DOI: 10.1007/s10439-014-1209-z  1
2015 Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo R, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MR, Falahatpisheh A, Griffith B, Baaijens F, Little SH, Canic S. Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement. Annals of Biomedical Engineering. 43: 844-57. PMID 25449148 DOI: 10.1007/s10439-014-1191-5  1
2015 Mohammadi H, Arora PD, Simmons CA, Janmey PA, McCulloch CA. Inelastic behaviour of collagen networks in cell-matrix interactions and mechanosensation. Journal of the Royal Society, Interface / the Royal Society. 12: 20141074. PMID 25392399 DOI: 10.1098/rsif.2014.1074  1
2015 Kheradvar A, Groves EM, Simmons CA, Griffith B, Alavi SH, Tranquillo R, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MR, Baaijens F, Canic S, Little SH. Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement. Annals of Biomedical Engineering. 43: 858-70. PMID 25287646 DOI: 10.1007/s10439-014-1129-y  1
2015 Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW. Correction: Design and formulation of functional pluripotent stem cell-derived cardiac microtissues (Proceedings of the National Academy of Sciences (2013) 110, (E4698-E4707) DOI:10.1073/pnas.1311120110) Proceedings of the National Academy of Sciences of the United States of America. 112: E3151. DOI: 10.1073/pnas.1509023112  1
2015 Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MK, Hamed Alavi S, Tranquillo R, Dasi LP, Simmons CA, Jane Grande-Allen K, Goergen CJ, Baaijens F, Little SH, Canic S, Griffith B. Emerging Trends in Heart Valve Engineering: Part IV. Computational Modeling and Experimental Studies Annals of Biomedical Engineering. DOI: 10.1007/s10439-015-1394-4  1
2015 Blaser MC, Simmons CA. Mechanical and matrix regulation of valvular fibrosis Cardiac Fibrosis and Heart Failure: Cause or Effect?. 23-53. DOI: 10.1007/978-3-319-17437-2_3  1
2014 Sider KL, Zhu C, Kwong AV, Mirzaei Z, de Langé CF, Simmons CA. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 23: 289-97. PMID 24998316 DOI: 10.1016/j.carpath.2014.05.004  1
2014 Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA, Sun Y. In situ mechanical characterization of the cell nucleus by atomic force microscopy. Acs Nano. 8: 3821-8. PMID 24673613 DOI: 10.1021/nn500553z  1
2014 Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold. Acta Biomaterialia. 10: 1146-55. PMID 24361424 DOI: 10.1016/j.actbio.2013.12.022  1
2014 Liu H, Tan Q, Geddie WR, Jewett MA, Phillips N, Ke D, Simmons CA, Sun Y. Biophysical characterization of bladder cancer cells with different metastatic potential. Cell Biochemistry and Biophysics. 68: 241-6. PMID 23793959 DOI: 10.1007/s12013-013-9702-9  1
2013 Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proceedings of the National Academy of Sciences of the United States of America. 110: E4698-707. PMID 24255110 DOI: 10.1073/pnas.1311120110  1
2013 Heckler AF, Mirzaei Z, Pereira I, Simmons CA, Gong SG. Development of a three-dimensional in vitro model system to study orthodontic tooth movement Archives of Oral Biology. 58: 1498-1510. PMID 23845751 DOI: 10.1016/j.archoralbio.2013.06.011  1
2013 Gould ST, Srigunapalan S, Simmons CA, Anseth KS. Hemodynamic and cellular response feedback in calcific aortic valve disease. Circulation Research. 113: 186-97. PMID 23833293 DOI: 10.1161/CIRCRESAHA.112.300154  1
2013 Liu H, Sun Y, Simmons CA. Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates. Journal of Biomechanics. 46: 1967-71. PMID 23746597 DOI: 10.1016/j.jbiomech.2013.05.001  1
2013 MacQueen L, Sun Y, Simmons CA. Mesenchymal stem cell mechanobiology and emerging experimental platforms. Journal of the Royal Society, Interface / the Royal Society. 10: 20130179. PMID 23635493 DOI: 10.1098/rsif.2013.0179  1
2013 Chen MB, Srigunapalan S, Wheeler AR, Simmons CA. A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell-cell interactions. Lab On a Chip. 13: 2591-8. PMID 23525275 DOI: 10.1039/c3lc00051f  1
2013 Moraes C, Likhitpanichkul M, Lam CJ, Beca BM, Sun Y, Simmons CA. Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 673-80. PMID 23403640 DOI: 10.1039/c3ib20254b  1
2013 Zhao R, Simmons CA. A simple method to estimate the exponential material parameters of heart valve tissue based on analogy between uniaxial tension and micropipette aspiration. Biomechanics and Modeling in Mechanobiology. 12: 1283-90. PMID 23355188 DOI: 10.1007/s10237-013-0470-7  1
2013 Doyle MG, Chehade M, Simmons CA. A novel device for the microindentation of soft biomaterials with application to aortic valve leaflets Asme 2013 Summer Bioengineering Conference, Sbc 2013. 1. DOI: 10.1115/SBC2013-14733  1
2012 Al-Haque S, Miklas JW, Feric N, Chiu LL, Chen WL, Simmons CA, Radisic M. Hydrogel substrate stiffness and topography interact to induce contact guidance in cardiac fibroblasts. Macromolecular Bioscience. 12: 1342-53. PMID 22927323 DOI: 10.1002/mabi.201200042  1
2012 MacQueen L, Chebotarev O, Simmons CA, Sun Y. Miniaturized platform with on-chip strain sensors for compression testing of arrayed materials. Lab On a Chip. 12: 4178-84. PMID 22885688 DOI: 10.1039/c2lc40670e  1
2012 Wyss K, Yip CY, Mirzaei Z, Jin X, Chen JH, Simmons CA. The elastic properties of valve interstitial cells undergoing pathological differentiation. Journal of Biomechanics. 45: 882-7. PMID 22189247 DOI: 10.1016/j.jbiomech.2011.11.030  1
2012 Srigunapalan S, Eydelnant IA, Simmons CA, Wheeler AR. A digital microfluidic platform for primary cell culture and analysis. Lab On a Chip. 12: 369-75. PMID 22094822 DOI: 10.1039/c1lc20844f  1
2012 Zhao R, Simmons CA. An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain. Journal of Biomechanics. 45: 76-82. PMID 22030122 DOI: 10.1016/j.jbiomech.2011.10.003  1
2012 Cheung WY, Simmons CA, You L. Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression. Bone. 50: 104-10. PMID 21986000 DOI: 10.1016/j.bone.2011.09.052  1
2012 Liu H, Simmons CA, Sun Y. Characterization of the elasticity of valve interstitial cells on soft substrates using atomic force microscopy Asme 2012 Summer Bioengineering Conference, Sbc 2012. 831-832. DOI: 10.1115/SBC2012-80369  1
2012 Beca BM, Moraes C, Nichol J, Khademhosseini A, Sun Y, Simmons CA. A platform for combinatorial mechanobiological stimulation of engineered microtissues Proceedings of the 16th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2012. 37-39.  1
2012 MacQueen L, Chebotarev O, Chen M, Usprech J, Sun Y, Simmons CA. Three-dimensional mechanical compression of biomaterials in a microfabricated bioreactor with on-chip strain sensors Proceedings of the 16th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2012. 1141-1143.  1
2011 Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation. 124: 1783-91. PMID 22007101 DOI: 10.1161/CIRCULATIONAHA.110.006767  1
2011 Moraes C, Sun Y, Simmons CA. (Micro)managing the mechanical microenvironment. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 959-71. PMID 21931883 DOI: 10.1039/c1ib00056j  1
2011 Sider KL, Blaser MC, Simmons CA. Animal models of calcific aortic valve disease. International Journal of Inflammation. 2011: 364310. PMID 21826258 DOI: 10.4061/2011/364310  1
2011 Wiench M, John S, Baek S, Johnson TA, Sung MH, Escobar T, Simmons CA, Pearce KH, Biddie SC, Sabo PJ, Thurman RE, Stamatoyannopoulos JA, Hager GL. DNA methylation status predicts cell type-specific enhancer activity. The Embo Journal. 30: 3028-39. PMID 21701563 DOI: 10.1038/emboj.2011.210  0.36
2011 Chen JH, Simmons CA. Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues. Circulation Research. 108: 1510-24. PMID 21659654 DOI: 10.1161/CIRCRESAHA.110.234237  1
2011 Yip CY, Blaser MC, Mirzaei Z, Zhong X, Simmons CA. Inhibition of pathological differentiation of valvular interstitial cells by C-type natriuretic peptide. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1881-9. PMID 21617139 DOI: 10.1161/ATVBAHA.111.223974  1
2011 Srigunapalan S, Lam C, Wheeler AR, Simmons CA. A microfluidic membrane device to mimic critical components of the vascular microenvironment. Biomicrofluidics. 5: 13409. PMID 21522499 DOI: 10.1063/1.3530598  1
2011 Sharifpoor S, Simmons CA, Labow RS, Paul Santerre J. Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold. Biomaterials. 32: 4816-29. PMID 21463894 DOI: 10.1016/j.biomaterials.2011.03.034  1
2011 Cheung WY, Liu C, Tonelli-Zasarsky RM, Simmons CA, You L. Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 29: 523-30. PMID 21337392 DOI: 10.1002/jor.21283  1
2011 Yip CY, Simmons CA. The aortic valve microenvironment and its role in calcific aortic valve disease. Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 20: 177-82. PMID 21256052 DOI: 10.1016/j.carpath.2010.12.001  1
2011 Chen WL, Simmons CA. Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine. Advanced Drug Delivery Reviews. 63: 269-76. PMID 21241759 DOI: 10.1016/j.addr.2011.01.004  1
2011 Chen JH, Chen WL, Sider KL, Yip CY, Simmons CA. β-catenin mediates mechanically regulated, transforming growth factor-β1-induced myofibroblast differentiation of aortic valve interstitial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 590-7. PMID 21127288 DOI: 10.1161/ATVBAHA.110.220061  1
2011 Zhao R, Sider KL, Simmons CA. Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration. Acta Biomaterialia. 7: 1220-7. PMID 21056128 DOI: 10.1016/j.actbio.2010.11.004  1
2011 Moraes C, Zhao R, Likhitpanichkul M, Simmons CA, Sun Y. Semi-confined compression of microfabricated polymerized biomaterial constructs Journal of Micromechanics and Microengineering. 21. DOI: 10.1088/0960-1317/21/5/054014  1
2011 MacQueen LA, Simmons CA, Sun Y. Parallel screening of biomaterials and tissue constructs: Dynamic mechanical stimulation and on-chip strain sensing 15th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2011, Microtas 2011. 1: 142-144.  1
2010 Moraes C, Sun Y, Simmons CA. Microfabricated platforms for mechanically dynamic cell culture. Journal of Visualized Experiments : Jove. PMID 21206477 DOI: 10.3791/2224  1
2010 Lu Z, Moraes C, Ye G, Simmons CA, Sun Y. Single cell deposition and patterning with a robotic system. Plos One. 5: e13542. PMID 21042403 DOI: 10.1371/journal.pone.0013542  1
2010 Sharifpoor S, Simmons CA, Labow RS, Santerre JP. A study of vascular smooth muscle cell function under cyclic mechanical loading in a polyurethane scaffold with optimized porosity. Acta Biomaterialia. 6: 4218-28. PMID 20601230 DOI: 10.1016/j.actbio.2010.06.018  1
2010 Yuen A, Laschinger C, Talior I, Lee W, Chan M, Birek J, Young EW, Sivagurunathan K, Won E, Simmons CA, McCulloch CA. Methylglyoxal-modified collagen promotes myofibroblast differentiation. Matrix Biology : Journal of the International Society For Matrix Biology. 29: 537-48. PMID 20423729 DOI: 10.1016/j.matbio.2010.04.004  1
2010 Eilaghi A, Flanagan JG, Tertinegg I, Simmons CA, Wayne Brodland G, Ross Ethier C. Biaxial mechanical testing of human sclera. Journal of Biomechanics. 43: 1696-701. PMID 20399430 DOI: 10.1016/j.jbiomech.2010.02.031  1
2010 Fiddes LK, Raz N, Srigunapalan S, Tumarkan E, Simmons CA, Wheeler AR, Kumacheva E. A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions. Biomaterials. 31: 3459-64. PMID 20167361 DOI: 10.1016/j.biomaterials.2010.01.082  1
2010 Moraes C, Chen JH, Sun Y, Simmons CA. Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation. Lab On a Chip. 10: 227-34. PMID 20066251 DOI: 10.1039/b914460a  1
2010 Young EW, Simmons CA. Macro- and microscale fluid flow systems for endothelial cell biology. Lab On a Chip. 10: 143-60. PMID 20066241 DOI: 10.1039/b913390a  1
2010 Young EW, Watson MW, Srigunapalan S, Wheeler AR, Simmons CA. Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Analytical Chemistry. 82: 808-16. PMID 20050596 DOI: 10.1021/ac901560w  1
2010 Eilaghi A, Flanagan JG, Simmons CA, Ethier CR. Effects of scleral stiffness properties on optic nerve head biomechanics. Annals of Biomedical Engineering. 38: 1586-92. PMID 20039133 DOI: 10.1007/s10439-009-9879-7  1
2010 Chen WL, Likhitpanichkul M, Ho A, Simmons CA. Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions. Biomaterials. 31: 2489-97. PMID 20034663 DOI: 10.1016/j.biomaterials.2009.12.002  1
2010 Bhana B, Iyer RK, Chen WL, Zhao R, Sider KL, Likhitpanichkul M, Simmons CA, Radisic M. Influence of substrate stiffness on the phenotype of heart cells. Biotechnology and Bioengineering. 105: 1148-60. PMID 20014437 DOI: 10.1002/bit.22647  1
2010 Moraes C, Wang G, Sun Y, Simmons CA. A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays. Biomaterials. 31: 577-84. PMID 19819010 DOI: 10.1016/j.biomaterials.2009.09.068  1
2010 Chen JH, Liu C, You L, Simmons CA. Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone. Journal of Biomechanics. 43: 108-18. PMID 19818443 DOI: 10.1016/j.jbiomech.2009.09.016  1
2010 Zhao R, Lin L, Simmons CA. The effects of cell contraction and loss of adhesion on the apoptosis of valve intersitial cells Asme 2010 Summer Bioengineering Conference, Sbc 2010. 969-970. DOI: 10.1115/SBC2010-19249  1
2010 Zhao R, Sider KL, Simmons CA. Comparison of analytical and finite element implementation of exponential constitutive models for valve tissue under micropipette aspiration Asme 2010 Summer Bioengineering Conference, Sbc 2010. 275-276. DOI: 10.1115/SBC2010-19245  1
2010 Lu Z, Moraes C, Zhao Y, You L, Simmons CA, Sun Y. A micromanipulation system for single cell deposition Proceedings - Ieee International Conference On Robotics and Automation. 494-499. DOI: 10.1109/ROBOT.2010.5509784  1
2010 Rask F, Mihic A, Reis L, Dallabrida SM, Ismail NS, Sider K, Simmons CA, Rupnick MA, Weisel RD, Li RK, Radisic M. Hydrogels modified with QHREDGS peptide support cardiomyocyte survival in vitro and after sub-cutaneous implantation Soft Matter. 6: 5089-5099. DOI: 10.1039/c0sm00362j  1
2010 Moraes C, Wyss K, Brisson E, Keith BA, Sun Y, Simmons CA. An undergraduate lab (on-a-chip): Probing single cell mechanics on a microfluidic platform Cellular and Molecular Bioengineering. 3: 319-330. DOI: 10.1007/s12195-010-0124-0  1
2010 Moraes C, Lam CJ, Beca BM, Sun Y, Simmons CA. Composite material diaphragm arrays for mechanobiological stimulation of cultured cells 14th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2010, Microtas 2010. 2: 851-853.  1
2009 Brooks PJ, Nilforoushan D, Manolson MF, Simmons CA, Gong SG. Molecular markers of early orthodontic tooth movement. The Angle Orthodontist. 79: 1108-13. PMID 19852601 DOI: 10.2319/121508-638R.1  1
2009 Zhao R, Wyss K, Simmons CA. Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. Journal of Biomechanics. 42: 2768-73. PMID 19765713 DOI: 10.1016/j.jbiomech.2009.07.035  1
2009 Moraes C, Kagoma YK, Beca BM, Tonelli-Zasarsky RL, Sun Y, Simmons CA. Integrating polyurethane culture substrates into poly(dimethylsiloxane) microdevices. Biomaterials. 30: 5241-50. PMID 19545891 DOI: 10.1016/j.biomaterials.2009.05.066  1
2009 Simmons CA. Aortic valve mechanics: an emerging role for the endothelium. Journal of the American College of Cardiology. 53: 1456-8. PMID 19371830 DOI: 10.1016/j.jacc.2008.12.052  1
2009 Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 936-42. PMID 19304575 DOI: 10.1161/ATVBAHA.108.182394  1
2009 Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. The American Journal of Pathology. 174: 1109-19. PMID 19218344 DOI: 10.2353/ajpath.2009.080750  1
2009 Fiddes LK, Chan HK, Wyss K, Simmons CA, Kumacheva E, Wheeler AR. Augmenting microgel flow via receptor-ligand binding in the constrained geometries of microchannels. Lab On a Chip. 9: 286-90. PMID 19107286 DOI: 10.1039/b807106c  1
2009 Moraes C, Simmons CA, Sun Y. A high-throughput array for mechanical stimulation of adherent biological cells Transducers 2009 - 15th International Conference On Solid-State Sensors, Actuators and Microsystems. 2370-2373. DOI: 10.1109/SENSOR.2009.5285449  1
2009 Moraes C, Sun Y, Simmons CA. Solving the shrinkage-induced PDMS alignment registration issue in multilayer soft lithography Journal of Micromechanics and Microengineering. 19. DOI: 10.1088/0960-1317/19/6/065015  1
2009 Young EWK, Simmons CA. "Student lab"-on-a-chip: Integrating low-cost microfluidics into undergraduate teaching labs to study multiphase flow phenomena in small vessels Chemical Engineering Education. 43: 232-240.  1
2009 Rajabi S, Simmons CA, Ethier CR. Design of experiments for exposure of astrocytes to elevated hydrostatic pressure and hypoxia Proceedings of the Asme Summer Bioengineering Conference, Sbc2008. 1017-1018.  1
2009 Zhao R, Wyss K, Simmons CA. Comparison of three material models to predict the time-dependent deformation of a single cell under micropipette aspiration Proceedings of the Asme Summer Bioengineering Conference, Sbc2008. 1051-1052.  1
2009 Moraes C, Likhitpanichkul M, Sun Y, Simmons CA. High-throughput compressive stimulation of three-dimensional confined biomaterials on a microfabricated platform Proceedings of Conference, Microtas 2009 - the 13th International Conference On Miniaturized Systems For Chemistry and Life Sciences. 1838-1840.  1
2009 Moraes C, Beca BM, Sun Y, Simmons CA. Combinatorial high-throughput screening for mechanobiological factors affecting myofibroblast differentiation Proceedings of Conference, Microtas 2009 - the 13th International Conference On Miniaturized Systems For Chemistry and Life Sciences. 676-678.  1
2008 Cheung WY, Young EW, Simmons CA. Techniques for isolating and purifying porcine aortic valve endothelial cells. The Journal of Heart Valve Disease. 17: 674-81. PMID 19137801  1
2008 Simmons CA, Bledsoe RK, Guex N, Pearce KH. Expression, purification, and characterization of multiple, multifunctional human glucocorticoid receptor proteins. Protein Expression and Purification. 62: 29-35. PMID 18694832 DOI: 10.1016/j.pep.2008.07.008  0.36
2008 Butcher JT, Simmons CA, Warnock JN. Mechanobiology of the aortic heart valve. The Journal of Heart Valve Disease. 17: 62-73. PMID 18365571  1
2008 Spiteri CG, Young EW, Simmons CA, Kandel RA, Pilliar RM. Substrate architecture and fluid-induced shear stress during chondrocyte seeding: role of alpha5beta1 integrin. Biomaterials. 29: 2477-89. PMID 18314188 DOI: 10.1016/j.biomaterials.2008.01.018  1
2008 Pho M, Lee W, Watt DR, Laschinger C, Simmons CA, McCulloch CA. Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves American Journal of Physiology - Heart and Circulatory Physiology. 294. PMID 18263709 DOI: 10.1152/ajpheart.01305.2007  1
2008 Tong J, Simmons CA, Sun Y. Precision patterning of PDMS membranes and applications Journal of Micromechanics and Microengineering. 18. DOI: 10.1088/0960-1317/18/3/037004  1
2008 Li W, Young EWK, Seo M, Nie Z, Garstecki P, Simmons CA, Kumacheva E. Simultaneous generation of droplets with different dimensions in parallel integrated microfluidic droplet generators Soft Matter. 4: 258. DOI: 10.1039/b712917c  1
2008 Moraes C, Sun Y, Simmons CA. Combinatorial evaluation of mechanosensitive biomaterials in a high-throughput microfabricated system 8th World Biomaterials Congress 2008. 2: 703.  1
2008 Moraes C, Simmons CA, Sun Y. Solving the shrinkage-induced PDMS registration problem in multilayer soft lithography 12th International Conference On Miniaturized Systems For Chemistry and Life Sciences - the Proceedings of Microtas 2008 Conference. 191-193.  1
2007 Young EW, Wheeler AR, Simmons CA. Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels. Lab On a Chip. 7: 1759-66. PMID 18030398 DOI: 10.1039/b712486d  1
2007 Chong SA, Lee W, Arora PD, Laschinger C, Young EW, Simmons CA, Manolson M, Sodek J, McCulloch CA. Methylglyoxal inhibits the binding step of collagen phagocytosis. The Journal of Biological Chemistry. 282: 8510-20. PMID 17229729 DOI: 10.1074/jbc.M609859200  1
2005 Hoekstra WJ, Patel HS, Liang X, Blanc JB, Heyer DO, Willson TM, Iannone MA, Kadwell SH, Miller LA, Pearce KH, Simmons CA, Shearin J. Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling. Journal of Medicinal Chemistry. 48: 2243-7. PMID 15771467 DOI: 10.1021/jm040154f  0.36
2005 Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circulation Research. 96: 792-9. PMID 15761200 DOI: 10.1161/01.RES.0000161998.92009.64  1
2005 Murphy WL, Hsiong S, Richardson TP, Simmons CA, Mooney DJ. Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials. 26: 303-10. PMID 15262472 DOI: 10.1016/j.biomaterials.2004.02.034  1
2004 Simmons CA, Zilberberg J, Davies PF. A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Annals of Biomedical Engineering. 32: 1453-9. PMID 15535062 DOI: 10.1114/B:ABME.0000042360.57960.2b  1
2004 Pearce KH, Iannone MA, Simmons CA, Gray JG. Discovery of novel nuclear receptor modulating ligands: an integral role for peptide interaction profiling. Drug Discovery Today. 9: 741-51. PMID 15450240 DOI: 10.1016/S1359-6446(04)03201-5  0.36
2004 Simmons CA, Nikolovski J, Thornton AJ, Matlis S, Mooney DJ. Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. Journal of Biomechanics. 37: 1531-41. PMID 15336928 DOI: 10.1016/j.jbiomech.2004.01.006  1
2004 Davies PF, Passerini AG, Simmons CA. Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1331-3. PMID 15297285 DOI: 10.1161/01.ATV.0000130659.89433.c1  1
2004 Simmons CA, Alsberg E, Hsiong S, Kim WJ, Mooney DJ. Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone. 35: 562-9. PMID 15268909 DOI: 10.1016/j.bone.2004.02.027  1
2004 Murphy WL, Simmons CA, Kaigler D, Mooney DJ. Bone regeneration via a mineral substrate and induced angiogenesis. Journal of Dental Research. 83: 204-10. PMID 14981120  1
2004 Iannone MA, Simmons CA, Kadwell SH, Svoboda DL, Vanderwall DE, Deng SJ, Consler TG, Shearin J, Gray JG, Pearce KH. Correlation between in vitro peptide binding profiles and cellular activities for estrogen receptor-modulating compounds. Molecular Endocrinology (Baltimore, Md.). 18: 1064-81. PMID 14976226 DOI: 10.1210/me.2003-0432  0.36
2003 Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. Journal of Biomechanics. 36: 1087-96. PMID 12831733 DOI: 10.1016/S0021-9290(03)00110-6  1
2002 Simmons CA, Nikolovski J, Mooney DJ. Calcification by vascular cells is regulated by mechanical strain and MAPK signaling Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 381-382.  1
2002 Nikolovski J, Simmons CA, Mooney DJ. Regulation of bone-associated genes in smooth muscle with mechanical strain Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 314-315.  1
2002 Murphy WL, Simmons CA, Mooney DJ. A combination approach to engineering bone regeneration: Biomineral presentation and induced angiogenesis Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 886-887.  1
2001 Deng SJ, Liu W, Simmons CA, Moore JT, Tian G. Identifying substrates for endothelium-specific Tie-2 receptor tyrosine kinase from phage-displayed peptide libraries for high throughput screening. Combinatorial Chemistry & High Throughput Screening. 4: 525-33. PMID 11562257  0.36
2001 Simmons CA, Meguid SA, Pilliar RM. Mechanical regulation of localized and appositional bone formation around bone-interfacing implants Journal of Biomedical Materials Research. 55: 63-71. PMID 11426399 DOI: 10.1002/1097-4636(200104)55:1<63::AID-JBM90>3.0.CO;2-V  1
2001 Simmons CA, Meguid SA, Pilliar RM. Differences in osseointegration rate due to implant surface geometry can be explained by local tissue strains Journal of Orthopaedic Research. 19: 187-194. PMID 11347689 DOI: 10.1016/S0736-0266(00)90006-8  1
2000 Simmons CA, Meguid SA, Pilliar RM. Modelling of mechanically regulated tissue formation around bone-interfacing implants American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 48: 21-22.  1
1999 Buckholz RG, Simmons CA, Stuart JM, Weiner MP. Automation of yeast two-hybrid screening Journal of Molecular Microbiology and Biotechnology. 1: 135-140. PMID 10941795  0.36
1999 Simmons CA, Valiquette N, Pilliar RM. Osseointegration of sintered porous-surfaced and plasma spray-coated implants: An animal model study of early postimplantation healing response and mechanical stability Journal of Biomedical Materials Research. 47: 127-138. PMID 10449624 DOI: 10.1002/(SICI)1097-4636(199911)47:2<127::AID-JBM3>3.0.CO;2-C  1
1997 Simmons CA, Hipp JA. Method-based differences in the automated analysis of the three-dimensional morphology of trabecular bone. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 12: 942-7. PMID 9169354 DOI: 10.1359/jbmr.1997.12.6.942  1
1996 Hipp JA, Jansujwicz A, Simmons CA, Snyder BD. Trabecular bone morphology from micro-magnetic resonance imaging Journal of Bone and Mineral Research. 11: 286-292. PMID 8822353  1
Show low-probability matches.