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Dennis E. Discher, Ph.D. - Publications

Affiliations: 
Chemical & Biomolecular Engineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
cell biophysics and polymer engineering
Website:
http://www.seas.upenn.edu/~discher/index.html
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331 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Tobin MP, Pfeifer CR, Zhu PK, Hayes BH, Wang M, Vashisth M, Xia Y, Phan SH, Belt SA, Irianto J, Discher DE. Differences in cell shape, motility, and growth reflect chromosomal number variations that can be visualized with live-cell ChReporters. Molecular Biology of the Cell. 34: br19. PMID 37903225 DOI: 10.1091/mbc.E23-06-0207  0.798
2023 Hayes BH, Zhu PK, Wang M, Pfeifer CR, Xia Y, Phan S, Andrechak JC, Du J, Tobin MP, Anlas A, Dooling LJ, Vashisth M, Irianto J, Lampson MA, Discher DE. Confinement plus myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters. Journal of Cell Science. 136. PMID 37288769 DOI: 10.1242/jcs.260753  0.788
2023 Hayes BH, Zhu PK, Wang M, Pfeifer CR, Xia Y, Phan S, Andrechak JC, Du J, Tobin MP, Anlas A, Dooling LJ, Vashisth M, Irianto J, Lampson MA, Discher DE. Confinement plus Myosin-II suppression maximizes heritable loss of chromosomes, as revealed by live-cell ChReporters. Journal of Cell Science. PMID 37158012 DOI: 10.1242/jcs.260753  0.796
2023 Dooling LJ, Andrechak JC, Hayes BH, Kadu S, Zhang W, Pan R, Vashisth M, Irianto J, Alvey CM, Ma L, Discher DE. Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses. Nature Biomedical Engineering. PMID 37095318 DOI: 10.1038/s41551-023-01031-3  0.778
2022 Cho S, Discher DE, Leong KW, Vunjak-Novakovic G, Wu JC. Challenges and opportunities for the next generation of cardiovascular tissue engineering. Nature Methods. 19: 1064-1071. PMID 36064773 DOI: 10.1038/s41592-022-01591-3  0.685
2022 Dooling LJ, Saini K, Anlaş AA, Discher DE. Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 35764212 DOI: 10.1016/j.matbio.2022.06.006  0.787
2022 Wang M, Ivanovska I, Vashisth M, Discher DE. Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins. Apl Bioengineering. 6: 021504. PMID 35719698 DOI: 10.1063/5.0080392  0.776
2022 Pfeifer CR, Tobin MP, Cho S, Vashisth M, Dooling LJ, Vazquez LL, Ricci-De Lucca EG, Simon KT, Discher DE. Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate. Nucleus (Austin, Tex.). 13: 129-143. PMID 35293271 DOI: 10.1080/19491034.2022.2045726  0.802
2021 Vashisth M, Cho S, Irianto J, Xia Y, Wang M, Hayes B, Wieland D, Wells R, Jafarpour F, Liu A, Discher DE. Scaling concepts in 'omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34810266 DOI: 10.1073/pnas.2112940118  0.777
2020 Jalil AR, Hayes BH, Andrechak JC, Xia Y, Chenoweth DM, Discher DE. Multivalent, Soluble Nano-Self Peptides Increase Phagocytosis of Antibody-Opsonized Targets while Suppressing "Self" Signaling. Acs Nano. 14: 15083-15093. PMID 33186026 DOI: 10.1021/acsnano.0c05091  0.665
2020 Hayes BH, Tsai RK, Dooling LJ, Kadu S, Lee JY, Pantano D, Rodriguez PL, Subramanian S, Shin JW, Discher DE. Macrophages eat more after disruption of interactions between CD47 and the checkpoint receptor SIRPα. Journal of Cell Science. PMID 31964705 DOI: 10.1242/Jcs.237800  0.72
2020 Saini K, Tewari M, Cho S, Jalil A, Irianto J, Vashisth M, Pfeifer C, Dooling LJ, Alvey C, Kasznel A, Chenoweth D, Yamamoto K, Discher DE. Heterogeneously Strained Tissue Collagen Resists Collagenase Degradation Where Strains are High Biophysical Journal. 118: 398a. DOI: 10.1016/J.Bpj.2019.11.2261  0.764
2020 Zhu K, Xia Y, Irianto J, Andrechak JC, Dooling LJ, Pfeifer CR, Discher DE. Live Cell Monitoring of Chromosome Loss Reporter Biophysical Journal. 118: 376a. DOI: 10.1016/J.Bpj.2019.11.2152  0.778
2020 Discher DE, Vashisth M. Scaling Analyses of Tumor Transcriptomes Link Lamin-B to Proliferation and Poor Survival and Separately Link Fibrosis with Prolonged Survival Biophysical Journal. 118: 347a. DOI: 10.1016/J.Bpj.2019.11.2001  0.74
2020 Ivanovska IL, Tobin MP, Pfeifer CR, Discher DE. Lipid Droplets Deform Nucleus and Cause Mislocalization of DNA Repair Factors Biophysical Journal. 118: 283a-284a. DOI: 10.1016/J.Bpj.2019.11.1617  0.654
2020 Pfeifer CR, Tobin MP, Lopez L, Ricci-De Lucca EG, Simon KT, Discher DE. Beyond a Critical Strain, Lamin-A Dilates and Nuclei Rupture at Sites of High Curvature Biophysical Journal. 118: 283a. DOI: 10.1016/J.Bpj.2019.11.1615  0.63
2019 Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. Npj Regenerative Medicine. 4: 22. PMID 31815001 DOI: 10.1038/S41536-019-0083-6  0.332
2019 Pfeifer CR, Irianto J, Discher DE. Nuclear Mechanics and Cancer Cell Migration. Advances in Experimental Medicine and Biology. 1146: 117-130. PMID 31612457 DOI: 10.1007/978-3-030-17593-1_8  0.706
2019 Andrechak JC, Dooling LJ, Discher DE. The macrophage checkpoint CD47 : SIRPα for recognition of 'self' cells: from clinical trials of blocking antibodies to mechanobiological fundamentals. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 374: 20180217. PMID 31431181 DOI: 10.1098/Rstb.2018.0217  0.33
2019 Pfeifer CR, Vashisth M, Xia Y, Discher DE. Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: a brief review. Essays in Biochemistry. PMID 31366473 DOI: 10.1042/Ebc20190007  0.807
2019 Pfeifer CR, Discher DE. Pulling the Roof Down on Anchored Nuclei. Developmental Cell. 50: 130-131. PMID 31336096 DOI: 10.1016/J.Devcel.2019.07.003  0.673
2019 Discher DE. From DNA damage to epithelial integrity: new roles for cell forces. Molecular Biology of the Cell. 30: 1879-1881. PMID 31322996 DOI: 10.1091/Mbc.E19-06-0338  0.315
2019 Xia Y, Pfeifer CR, Zhu K, Irianto J, Liu D, Pannell K, Chen EJ, Dooling LJ, Tobin MP, Wang M, Ivanovska IL, Smith LR, Greenberg RA, Discher DE. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. The Journal of Cell Biology. PMID 31239284 DOI: 10.1083/Jcb.201811100  0.802
2019 Saini K, Cho S, Dooling LJ, Discher DE. Tension in fibrils suppresses their enzymatic degradation - A molecular mechanism for 'use it or lose it'. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 31201857 DOI: 10.1016/J.Matbio.2019.06.001  0.735
2019 Smith LR, Irianto J, Xia Y, Pfeifer CR, Discher DE. Constricted migration modulates stem cell differentiation. Molecular Biology of the Cell. mbcE19020090. PMID 31188712 DOI: 10.1091/Mbc.E19-02-0090  0.81
2019 Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, ... Discher DE, et al. Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. Developmental Cell. PMID 31105008 DOI: 10.1016/J.Devcel.2019.04.020  0.8
2019 Deviri D, Pfeifer CR, Dooling LJ, Ivanovska IL, Discher DE, Safran SA. Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina Nature Physics. 15: 823-829. DOI: 10.1038/S41567-019-0506-8  0.658
2019 Xia Y, Pfeifer C, Zhu K, Irianto J, Discher D. Rescue of DNA Damage After Constricted Migration by DNA Repair Factor Overexpression Biophysical Journal. 116: 119a. DOI: 10.1016/J.Bpj.2018.11.667  0.776
2019 Vashisth M, Cho S, Discher D. Role of Mis Localization of DNA Repair Factors in Cell Cycle Arrest Biophysical Journal. 116: 76a. DOI: 10.1016/J.Bpj.2018.11.454  0.787
2019 Dooling LJ, Andrechak JC, Pfeifer CR, Discher DE. Macrophage Checkpoint Blockade and Tumor Mechanics in a Cell-Based Immunotherapy Biophysical Journal. 116: 578a. DOI: 10.1016/J.Bpj.2018.11.3108  0.668
2019 Zhu K, Xia Y, Discher D. Loss of Chromosomes Monitored in Live Cells Biophysical Journal. 116: 415a. DOI: 10.1016/J.Bpj.2018.11.2238  0.677
2019 Pfeifer CR, Xia Y, Fang Hum Y, Zhu K, Liu D, Irianto J, Boot RC, Morales Garcia VM, Santiago Millan LM, Niese B, Deviri D, Greenberg RA, Discher DE. Constricted Migration Increases DNA Damage and Represses Cell Cycle Biophysical Journal. 116: 414a-415a. DOI: 10.1016/J.Bpj.2018.11.2235  0.793
2019 Saini K, Tewari M, Irianto J, Pfeifer C, Alvey C, Discher DE. Bending-Induced Strain Delays Collagen Degradation by Collagenase Biophysical Journal. 116: 379a. DOI: 10.1016/J.Bpj.2018.11.2060  0.637
2019 Ivanovska IL, Xia Y, Zhu K, Smith L, Alvey C, Irianto J, Pfeifer C, Ji J, Liu D, Cho S, Bennett R, Liu A, Greenberg RA, Discher DE. Nuclear Rupture at Sites of High Curvature Compromises Retention of DNA Repair Factors Biophysical Journal. 116: 19a. DOI: 10.1016/J.BPJ.2018.11.144  0.775
2019 Xia Y, Pfeifer CR, Discher DE. Nuclear mechanics during and after constricted migration Acta Mechanica Sinica. 35: 299-308. DOI: 10.1007/S10409-018-00836-9  0.818
2018 Xia Y, Pfeifer CR, Cho S, Discher DE, Irianto J. Nuclear mechanosensing. Emerging Topics in Life Sciences. 2: 713-725. PMID 31693005 DOI: 10.1042/ETLS20180051  0.79
2018 Engler AJ, Discher DE. Rationally engineered advances in cancer research. Apl Bioengineering. 2: 031601. PMID 31069310 DOI: 10.1063/1.5056176  0.474
2018 Xia Y, Cho S, Vashisth M, Ivanovska IL, Dingal PCDP, Discher DE. Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure. Methods (San Diego, Calif.). PMID 30593865 DOI: 10.1016/J.Ymeth.2018.12.009  0.8
2018 Novikova EA, Raab M, Discher DE, Storm C. Erratum: Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients [Phys. Rev. Lett. 118, 078103 (2017)]. Physical Review Letters. 121: 159901. PMID 30362797 DOI: 10.1103/Physrevlett.121.159901  0.728
2018 Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. The Journal of Cell Biology. PMID 30171044 DOI: 10.1016/J.Bpj.2018.11.144  0.788
2018 Steinkühler J, Różycki B, Alvey C, Lipowsky R, Weikl TR, Dimova R, Discher DE. Membrane fluctuations and acidosis regulate cooperative binding of "marker of self" CD47 with macrophage checkpoint receptor SIRPα. Journal of Cell Science. PMID 29777034 DOI: 10.1242/Jcs.216770  0.783
2018 Chakraborty K, Vijayan K, Brown AEX, Discher DE, Loverde SM. Glassy worm-like micelles in solvent and shear mediated shape transitions. Soft Matter. PMID 29744515 DOI: 10.1039/C8Sm00080H  0.563
2018 Pfeifer CR, Xia Y, Zhu K, Liu D, Irianto J, García VMM, Millán LMS, Niese B, Harding S, Deviri D, Greenberg RA, Discher DE. Constricted migration increases DNA damage and independently represses cell cycle. Molecular Biology of the Cell. mbcE18020079. PMID 29742017 DOI: 10.1091/Mbc.E18-02-0079  0.804
2018 Cho S, Abbas A, Irianto J, Ivanovska I, Xia Y, Tewari M, Discher DE. Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells. Nucleus (Austin, Tex.). 1-32. PMID 29619860 DOI: 10.1080/19491034.2018.1460185  0.804
2018 Nair P, Alvey C, Jin X, Irianto J, Ivanovska I, Discher DE. Filomicelles deliver a chemo-differentiation combination of Paclitaxel and Retinoic Acid that durably represses carcinomas in liver to prolong survival. Bioconjugate Chemistry. PMID 29451777 DOI: 10.1021/Acs.Bioconjchem.7B00816  0.783
2018 Smith LR, Cho S, Discher DE. Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics. Physiology (Bethesda, Md.). 33: 16-25. PMID 29212889 DOI: 10.1152/Physiol.00026.2017  0.745
2018 Saini K, Tiwari M, Irianto J, Pfeifer C, Alvey C, Discher DE. Strained Collagen Resists Bacterial Collagenase Degradation Biophysical Journal. 114: 115a. DOI: 10.1016/J.Bpj.2017.11.661  0.626
2018 Ivanovska IL, Xia Y, Irianto J, Discher DE. Curvature Dependence of Nuclear Rupture Frequency Revealed by AFM Force Spectroscopy Biophysical Journal. 114: 654a. DOI: 10.1016/J.Bpj.2017.11.3534  0.662
2018 Alvey C, Pfeifer C, Irianto J, Xia Y, Smith L, Dooling L, Discher DE. Mechanosensing of Solid Tumors by Cancer-Attacking Macrophages Biophysical Journal. 114: 654a. DOI: 10.1016/J.Bpj.2017.11.3532  0.766
2018 Pfeifer CR, Morales Garcia VM, Santiago Millan LM, Niese B, Irianto J, Discher DE. Cell Cycle Inhibition by Constricted Migration Biophysical Journal. 114: 653a-654a. DOI: 10.1016/J.Bpj.2017.11.3530  0.668
2018 Irianto J, Xia Y, Pfeifer CR, Athirasala A, Ji J, Alvey CM, Tewari M, Bennett RR, Harding SM, Liu AJ, Greenberg RA, Discher DE. Repair Factor Loss and Genome Variation in Cancer Cell Invasion Biophysical Journal. 114: 653a. DOI: 10.1016/J.Bpj.2017.11.3526  0.785
2018 Cho S, Majkut S, Abbas A, Vogel K, Vashisth M, Irianto J, Tewari M, Liu A, Prosser B, Discher DE. Mechanosensing to Protect the Genome from DNA Damage during Development Biophysical Journal. 114: 516a. DOI: 10.1016/J.Bpj.2017.11.2819  0.765
2018 Xia Y, Irianto J, Zhu K, Alvey C, Smith L, Pfeifer C, Discher D. Matrix Rigidity Myosin-II and Lamin-A Regulate Curvature Induced Nuclear Rupture Causing Repair Factor Mislocalization and DNA Damage Biophysical Journal. 114: 515a. DOI: 10.1016/J.Bpj.2017.11.2814  0.789
2017 Holle AW, Young JL, Van Vliet KJ, Kamm RD, Discher D, Janmey P, Spatz JP, Saif T. Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research. Nano Letters. PMID 29178811 DOI: 10.1021/Acs.Nanolett.7B04982  0.803
2017 Pfeifer CR, Alvey CM, Irianto J, Discher DE. Genome variation across cancers scales with tissue stiffness - an invasion-mutation mechanism and implications for immune cell infiltration. Current Opinion in Systems Biology. 2: 103-114. PMID 29082336 DOI: 10.1016/J.Coisb.2017.04.005  0.793
2017 Buxboim A, Irianto J, Swift J, Athirasala A, Shin JW, Rehfeldt F, Discher DE. Coordinated increase of nuclear tension and lamin-A with matrix stiffness out-competes Lamin-B Receptor which favors soft tissue phenotypes. Molecular Biology of the Cell. PMID 28931598 DOI: 10.1091/Mbc.E17-06-0393  0.545
2017 Deviri D, Discher DE, Safran SA. Rupture Dynamics and Chromatin Herniation in Deformed Nuclei. Biophysical Journal. 113: 1060-1071. PMID 28877489 DOI: 10.1016/J.Bpj.2017.07.014  0.375
2017 Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA. Mitotic progression following DNA damage enables pattern recognition within micronuclei. Nature. PMID 28759889 DOI: 10.1038/Nature23470  0.309
2017 Alvey CM, Spinler KR, Irianto J, Pfeifer CR, Hayes B, Xia Y, Cho S, Dingal PCPD, Hsu J, Smith L, Tewari M, Discher DE. SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors. Current Biology : Cb. PMID 28669759 DOI: 10.1016/J.Cub.2017.06.005  0.779
2017 Bennett RR, Pfeifer CR, Irianto J, Xia Y, Discher DE, Liu AJ. Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration. Biophysical Journal. 112: 2271-2279. PMID 28591600 DOI: 10.1016/J.Bpj.2017.04.037  0.792
2017 Smith L, Cho S, Discher DE. Mechanosensing of matrix by stem cells: from contractility and matrix heterogeneity to cardiogenesis and muscle stem cells. Seminars in Cell & Developmental Biology. PMID 28587976 DOI: 10.1016/J.Semcdb.2017.05.025  0.754
2017 Ivanovska IL, Swift J, Spinler K, Dingal D, Cho S, Discher DE. Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation. Molecular Biology of the Cell. PMID 28566555 DOI: 10.1091/Mbc.E17-01-0010  0.803
2017 Mahmud A, Harada T, Rajagopal K, Christian DA, Nair P, Murphy R, Discher DE. Spray stability of self-assembled filaments for delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28549950 DOI: 10.1016/J.Jconrel.2017.05.026  0.779
2017 Discher DE, Smith L, Cho S, Colasurdo M, García AJ, Safran S. Matrix Mechanosensing: From Scaling Concepts in 'Omics Data to Mechanisms in the Nucleus, Regeneration, and Cancer. Annual Review of Biophysics. 46: 295-315. PMID 28532215 DOI: 10.1146/Annurev-Biophys-062215-011206  0.755
2017 Alvey C, Discher DE. Engineering macrophages to eat cancer: from "marker of self" CD47 and phagocytosis to differentiation. Journal of Leukocyte Biology. PMID 28522599 DOI: 10.1189/Jlb.4Ri1216-516R  0.79
2017 Irianto J, Xia Y, Pfeifer CR, Greenberg RA, Discher DE. As a Nucleus Enters a Small Pore, Chromatin Stretches and Maintains Integrity, Even with DNA Breaks. Biophysical Journal. 112: 446-449. PMID 28341535 DOI: 10.1016/J.Bpj.2016.09.047  0.795
2017 Novikova EA, Raab M, Discher DE, Storm C. Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients. Physical Review Letters. 118: 078103. PMID 28256894 DOI: 10.1103/Physrevlett.118.078103  0.756
2017 Cho S, Irianto J, Discher DE. Mechanosensing by the nucleus: From pathways to scaling relationships. The Journal of Cell Biology. PMID 28043971 DOI: 10.1083/Jcb.201610042  0.73
2017 Irianto J, Xia Y, Pfeifer CR, Athirasala A, Ji J, Alvey CA, Tewari M, Bennett RR, Harding SM, Liu AJ, Greenberg RA, Discher DE. Genomic Variation in an Osteosarcoma Cell Line Caused by Pore Migration Biophysical Journal. 112: 123a. DOI: 10.1016/J.Bpj.2016.11.689  0.811
2017 Xia Y, Irianto J, Pfeifer C, Greenberg R, Discher D. Inhibition of a DNA Repair Kinase ATM Leads to Cell Death in 3D Migration Independent of DNA Damage Biophysical Journal. 112: 123a. DOI: 10.1016/J.Bpj.2016.11.688  0.799
2017 Novikova EA, Raab M, Discher DE, Storm C. Cellular Durotaxis from Differentially Persistent Motility Biophysical Journal. 112: 436a. DOI: 10.1016/J.Bpj.2016.11.2327  0.76
2017 Cho S, Majkut S, Abbas A, Vogel K, Irianto J, Chen CY, Tewari M, Liu A, Prosser B, Discher DE. As the Beating Heart Stiffens in Development, So Does the Nuclear Lamina Biophysical Journal. 112: 433a. DOI: 10.1016/J.Bpj.2016.11.2311  0.788
2017 Nair PR, Alvey C, Discher D. Filovirus Mimics Deliver Effectively to Irreversibly Control Carcinoma Cell Fate Biophysical Journal. 112: 303a. DOI: 10.1016/J.Bpj.2016.11.1638  0.797
2016 Chin L, Xia Y, Discher DE, Janmey PA. Mechanotransduction in cancer. Current Opinion in Chemical Engineering. 11: 77-84. PMID 28344926 DOI: 10.1016/J.Coche.2016.01.011  0.714
2016 Sosale NG, Ivanovska II, Tsai RK, Swift J, Hsu JW, Alvey CM, Zoltick PW, Discher DE. "Marker of Self" CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors. Molecular Therapy. Methods & Clinical Development. 3: 16080. PMID 28053997 DOI: 10.1038/Mtm.2016.80  0.79
2016 Irianto J, Xia Y, Pfeifer CR, Athirasala A, Ji J, Alvey C, Tewari M, Bennett RR, Harding SM, Liu AJ, Greenberg RA, Discher DE. DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration. Current Biology : Cb. PMID 27989676 DOI: 10.1016/J.Cub.2016.11.049  0.804
2016 Raab M, Discher DE. Matrix rigidity regulates the microtubule network polarization in migration. Cytoskeleton (Hoboken, N.J.). PMID 27935261 DOI: 10.1002/Cm.21349  0.775
2016 Irianto J, Pfeifer CR, Bennett RR, Xia Y, Ivanovska IL, Liu AJ, Greenberg RA, Discher DE. Nuclear constriction segregates mobile nuclear proteins away from chromatin. Molecular Biology of the Cell. PMID 27798234 DOI: 10.1091/Mbc.E16-06-0428  0.8
2016 Irianto J, Pfeifer CR, Ivanovska IL, Swift J, Discher DE. Nuclear lamins in cancer. Cellular and Molecular Bioengineering. 9: 258-267. PMID 27570565 DOI: 10.1007/S12195-016-0437-8  0.667
2016 Weinkopff T, Konradt C, Christian DA, Discher DE, Hunter CA, Scott P. Leishmania major Infection-Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease. Journal of Immunology (Baltimore, Md. : 1950). PMID 27474074 DOI: 10.4049/Jimmunol.1600717  0.658
2016 Chiou KK, Rocks JW, Chen CY, Cho S, Merkus KE, Rajaratnam A, Robison P, Tewari M, Vogel K, Majkut SF, Prosser BL, Discher DE, Liu AJ. Mechanical signaling coordinates the embryonic heartbeat. Proceedings of the National Academy of Sciences of the United States of America. PMID 27457951 DOI: 10.1073/Pnas.1520428113  0.772
2016 Irianto J, Pfeifer CR, Xia Y, Discher DE. SnapShot: Mechanosensing Matrix. Cell. 165: 1820-1820.e1. PMID 27315485 DOI: 10.1016/J.Cell.2016.06.002  0.807
2016 Nair PR, Karthick SA, Spinler KR, Vakili MR, Lavasanifar A, Discher DE. Filomicelles from aromatic diblock copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared with aliphatic copolymers. Nanomedicine (London, England). PMID 27177319 DOI: 10.2217/Nnm-2016-0007  0.784
2016 Discher DE. Cells might not see where they are, but they certainly feel the mechanics of their microenvironment! (Conference Presentation) Proceedings of Spie. 9710. DOI: 10.1117/12.2214465  0.36
2016 Alvey C, Spinler K, Tewari M, Discher D. 511. Engineered Donor Marrow Macrophages Phagocytose Cancer Cells and Aggressively Shrink Solid Tumor Xenografts Compared to Tumor Associated Macrophages Molecular Therapy. 24: S204. DOI: 10.1016/S1525-0016(16)33320-2  0.778
2016 Chin L, Xia Y, Discher DE, Janmey PA. Mechanotransduction in cancer Current Opinion in Chemical Engineering. 11: 77-84. DOI: 10.1016/j.coche.2016.01.011  0.623
2016 Ivanovska IL, Swift J, Spinler K, Dingal D, Discher DE. Matrix and Soluble Factor Pathways to Lineage Specification Biophysical Journal. 110: 95a. DOI: 10.1016/J.Bpj.2015.11.570  0.742
2016 Pfeifer CR, Irianto J, Discher DE. Segregation of Mobile Nuclear Proteins Away from Chromatin when the Nucleus is Constricted Biophysical Journal. 110: 622a. DOI: 10.1016/J.Bpj.2015.11.3336  0.689
2016 Nair PR, Spinler KR, Vakili MR, Lavasanifar A, Discher DE. Filovirus Mimics Deliver Effectively Biophysical Journal. 110: 504a. DOI: 10.1016/J.Bpj.2015.11.2694  0.801
2016 Irianto J, Pfeifer CR, Athirasala A, Ivanovska IL, Greenberg RE, Discher DE. Cell Invasion through Stiff Constrictions causes Mutations While Damaging the Nucleus Biophysical Journal. 110: 24a. DOI: 10.1016/J.Bpj.2015.11.192  0.7
2016 Irianto J, Pfeifer CR, Ivanovska IL, Swift J, Discher DE. Nuclear Lamins in Cancer Cellular and Molecular Bioengineering. 1-10. DOI: 10.1007/s12195-016-0437-8  0.636
2015 Sosale NG, Spinler KR, Alvey C, Discher DE. Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties. Current Opinion in Immunology. 35: 107-112. PMID 26172292 DOI: 10.1016/J.Coi.2015.06.013  0.788
2015 Dingal PC, Bradshaw AM, Cho S, Raab M, Buxboim A, Swift J, Discher DE. Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor. Nature Materials. PMID 26168347 DOI: 10.1038/Nmat4350  0.812
2015 Ivanovska IL, Shin JW, Swift J, Discher DE. Stem cell mechanobiology: diverse lessons from bone marrow. Trends in Cell Biology. PMID 26045259 DOI: 10.1016/J.Tcb.2015.04.003  0.535
2015 Shin JW, Discher DE. Blood and immune cell engineering: Cytoskeletal contractility and nuclear rheology impact cell lineage and localization: Biophysical regulation of hematopoietic differentiation and trafficking. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 633-42. PMID 25810145 DOI: 10.1002/Bies.201400166  0.536
2015 Paluch EK, Discher DE. Cell motion and mechanobiology. Molecular Biology of the Cell. 26: 1011. PMID 25767201 DOI: 10.1091/Mbc.E14-12-1590  0.369
2015 Dasbiswas K, Majkut S, Discher DE, Safran SA. Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating. Nature Communications. 6: 6085. PMID 25597833 DOI: 10.1016/J.Bpj.2014.11.2423  0.778
2015 Sosale NG, Rouhiparkouhi T, Bradshaw AM, Dimova R, Lipowsky R, Discher DE. Cell rigidity and shape override CD47's "self"-signaling in phagocytosis by hyperactivating myosin-II. Blood. 125: 542-52. PMID 25411427 DOI: 10.1182/Blood-2014-06-585299  0.795
2015 Spinler KR, Shin JW, Lambert MP, Discher DE. Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia. Blood. 125: 525-33. PMID 25395423 DOI: 10.1182/Blood-2014-05-576462  0.741
2015 Alvey CM, Spinler K, Tewari M, Discher D. Engineered Donor Marrow Macrophages Phagocytose Cancer Cells and Aggressively Shrink Solid Tumor Xenografts Compared to Tumor Associated Macrophages Blood. 126: 2214-2214. DOI: 10.1016/S1525-0016(16)33320-2  0.784
2015 Sosale N, Bradshaw A, Agudo J, Dimova R, Lipowsky R, Discher DE. Physics vs Biology of Phagocytosis: Cell Rigidity and Shape Override CD47 ‘Self’ Signaling in Phagocytosis by Hyperactivating Myosin-II Biophysical Journal. 108: 180a. DOI: 10.1016/J.Bpj.2014.11.996  0.79
2015 Irianto J, Athirasala A, Diegmiller R, Ivanovska I, Discher DE. Nuclear Damage in Highly Constrained Migration: From Lamina Defects to DNA Breaks Biophysical Journal. 108: 115a-116a. DOI: 10.1016/J.Bpj.2014.11.649  0.382
2015 Ivanovska IL, Swift J, Spinler K, Dingal PDP, Discher DE. Cross-Linked Matrix Rigidity and Soluble Factors Induce Differentiation via Distinct but Overlapping Pathways Biophysical Journal. 108: 560a-561a. DOI: 10.1016/J.Bpj.2014.11.3072  0.738
2014 Dingal PC, Wells RG, Discher DE. Simple insoluble cues specify stem cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 111: 18104-5. PMID 25512554 DOI: 10.1073/Pnas.1421562112  0.334
2014 Dingal PC, Discher DE. Systems mechanobiology: tension-inhibited protein turnover is sufficient to physically control gene circuits. Biophysical Journal. 107: 2734-43. PMID 25468352 DOI: 10.1016/J.Bpj.2014.10.042  0.352
2014 Nair PR, Discher DE. 23. From stealthy, controlled release polymersomes to cylinder-shaped 'filomicelles' for imaging and delivery: Original research article: Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles, 2004. Journal of Controlled Release : Official Journal of the Controlled Release Society. 190: 72-4. PMID 25356496 DOI: 10.1016/j.jconrel.2014.07.035  0.753
2014 Buxboim A, Swift J, Irianto J, Spinler KR, Dingal PC, Athirasala A, Kao YR, Cho S, Harada T, Shin JW, Discher DE. Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin. Current Biology : Cb. 24: 1909-17. PMID 25127216 DOI: 10.1016/J.Cub.2014.07.001  0.797
2014 Swift J, Discher DE. The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue. Journal of Cell Science. 127: 3005-15. PMID 24963133 DOI: 10.1242/Jcs.149203  0.37
2014 Oltra NS, Nair P, Discher DE. From stealthy polymersomes and filomicelles to "self" Peptide-nanoparticles for cancer therapy. Annual Review of Chemical and Biomolecular Engineering. 5: 281-99. PMID 24910917 DOI: 10.1146/Annurev-Chembioeng-060713-040447  0.782
2014 Dingal PC, Discher DE. Combining insoluble and soluble factors to steer stem cell fate. Nature Materials. 13: 532-7. PMID 24845982 DOI: 10.1038/Nmat3997  0.318
2014 Majkut S, Dingal PC, Discher DE. Stress sensitivity and mechanotransduction during heart development. Current Biology : Cb. 24: R495-501. PMID 24845682 DOI: 10.1016/J.Cub.2014.04.027  0.792
2014 Dingal PC, Discher DE. Material control of stem cell differentiation: challenges in nano-characterization. Current Opinion in Biotechnology. 28: 46-50. PMID 24832074 DOI: 10.1016/J.Copbio.2013.11.003  0.37
2014 Harada T, Swift J, Irianto J, Shin JW, Spinler KR, Athirasala A, Diegmiller R, Dingal PC, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. The Journal of Cell Biology. 204: 669-82. PMID 24567359 DOI: 10.1083/Jcb.201308029  0.805
2014 Shin JW, Buxboim A, Spinler KR, Swift J, Christian DA, Hunter CA, Léon C, Gachet C, Dingal PC, Ivanovska IL, Rehfeldt F, Chasis JA, Discher DE. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell. 14: 81-93. PMID 24268694 DOI: 10.1016/J.Stem.2013.10.009  0.803
2014 Harada T, Swift J, Irianto J, Shin JW, Spinler KR, Athirasala A, Diegmiller R, Dingal PCDP, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D-migration, but softness can limit survival Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972810  0.76
2014 Peppas NA, Duncan R, Wnek GE, Hoffman AS, Gao GH, Kim SW, Lee DS, Hadjiargyrou M, Touitou E, Ainbinder D, Mumper R, Rolland A, Niidome T, Labhasetwar V, Liu S, ... ... Discher D, et al. Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors Journal of Controlled Release. 190: 29-74. DOI: 10.1016/S0168-3659(14)00482-9  0.75
2014 Discher DE, Swift J, Spinler K, Shin J. Lamins Regulate Cell Trafficking and Lineage Maturation of Hematopoietic Cells Biophysical Journal. 106: 571a. DOI: 10.1016/J.Bpj.2013.11.3169  0.771
2014 Ivanovska IL, Swift J, Discher DE. Lamin-A is Mechanosensitive to Matrix Stiffness and Couples to the Retinoic Acid Pathway in Differentiation Biophysical Journal. 106: 8a. DOI: 10.1016/J.Bpj.2013.11.088  0.347
2013 Swift J, Harada T, Buxboim A, Shin JW, Tang HY, Speicher DW, Discher DE. Label-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells. Nucleus (Austin, Tex.). 4: 450-9. PMID 24448480 DOI: 10.4161/Nucl.27413  0.623
2013 Majkut S, Idema T, Swift J, Krieger C, Liu A, Discher DE. Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating. Current Biology : Cb. 23: 2434-9. PMID 24268417 DOI: 10.1016/J.Cub.2013.10.057  0.802
2013 Shin JW, Spinler KR, Swift J, Chasis JA, Mohandas N, Discher DE. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 18892-7. PMID 24191023 DOI: 10.1073/Pnas.1304996110  0.802
2013 Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, Pajerowski JD, Spinler KR, Shin JW, Tewari M, Rehfeldt F, Speicher DW, Discher DE. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science (New York, N.Y.). 341: 1240104. PMID 23990565 DOI: 10.1126/Science.1240104  0.791
2013 Suzuki A, Shin JW, Wang Y, Min SH, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS. RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation. Plos One. 8: e69315. PMID 23935982 DOI: 10.1371/Journal.Pone.0069315  0.464
2013 Shin JW, Swift J, Ivanovska I, Spinler KR, Buxboim A, Discher DE. Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation; Research in Biological Diversity. 86: 77-86. PMID 23790394 DOI: 10.1016/J.Diff.2013.05.001  0.765
2013 Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA. Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophysical Journal. 104: 759-69. PMID 23442954 DOI: 10.1016/J.Bpj.2013.01.006  0.321
2013 Rodriguez PL, Harada T, Christian DA, Pantano DA, Tsai RK, Discher DE. Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science (New York, N.Y.). 339: 971-5. PMID 23430657 DOI: 10.1126/Science.1229568  0.757
2013 Spinler K, Tian A, Christian DA, Pantano DA, Baumgart T, Discher DE. Dynamic domains in polymersomes: mixtures of polyanionic and neutral diblocks respond more rapidly to changes in calcium than to pH. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 7499-508. PMID 23327600 DOI: 10.1021/La304602E  0.768
2013 Baumann BC, Kao GD, Mahmud A, Harada T, Swift J, Chapman C, Xu X, Discher DE, Dorsey JF. Enhancing the efficacy of drug-loaded nanocarriers against brain tumors by targeted radiation therapy. Oncotarget. 4: 64-79. PMID 23296073 DOI: 10.18632/Oncotarget.777  0.502
2013 Nisha S, Discher DE. How Does CD47-SIRPα ‘Don’t Eat Me Signal’ Physically Signal Self Blood. 122: 953-953. DOI: 10.1182/Blood.V122.21.953.953  0.322
2013 Spinler KR, Shin J, Discher DE. Platelet-Like-Particles Sheared From Myosin-II-Inhibited Megakaryocytes Highlights The Elevated Thrombocrit Of May-Hegglin Anomaly Blood. 122: 2426-2426. DOI: 10.1182/Blood.V122.21.2426.2426  0.744
2013 Majkut SF, Discher DE, Swift J. Stiffening of Embryonic Myocarium during Development Parallels Myosin and Matrix Expression and Dynamically Matches Cell Function Biophysical Journal. 104: 156a. DOI: 10.1016/J.Bpj.2012.11.880  0.793
2013 Discher DE, Swift J. Lamin-A Levels Limit 3D-Migration but Protect against Migration-Induced Apoptosis Biophysical Journal. 104: 151a. DOI: 10.1016/J.Bpj.2012.11.858  0.377
2013 Rehfeldt F, Potyrala M, Brown AE, Zemel A, Discher DE. Stem Cell Nucleus Morphology is Modulated by Matrix Mechanics via the Cytoskeleton Biophysical Journal. 104: 151a. DOI: 10.1016/J.Bpj.2012.11.857  0.389
2013 Buxboim A, Swift J, Kao YC, Harada T, Discher DE. How Deeply Cells Feel: Nuclear Phenotypes Defined by Cellular Tactile Sensing Biophysical Journal. 104: 151a. DOI: 10.1016/J.Bpj.2012.11.855  0.589
2013 Shin J, Spinler KR, Swift J, Discher DE. Hierarchical Determination of Nuclear Deformability by Lamin Isoforms during Adult Hematopoiesis: Implications in Blood Cell Trafficking Biophysical Journal. 104: 150a-151a. DOI: 10.1016/j.bpj.2012.11.854  0.687
2013 Spinler K, Shin J, Discher DE. Shear-Optimized Platelet-Like-Particles from High Ploidy MKS: From Segregation to Composition and Activation Biophysical Journal. 104: 142a. DOI: 10.1016/j.bpj.2012.11.806  0.648
2013 Dingal PDP, Raab M, Shah P, Shin J, Discher D. Fibrillar Collagen is Equivalent to Stiff Matrix in Driving Marrow Stromal Cell Differentiation into a Matrix-Deficient, Myofibroblastic-Like Phenotype Biophysical Journal. 104: 686a-687a. DOI: 10.1016/J.Bpj.2012.11.3793  0.804
2013 Sosale N, Rouhi T, Lipowsky R, Discher DE. ‘Marker of Self’, CD47, Modulates Mechanical Forces Imposed by Macrophages during Phagocytosis Biophysical Journal. 104: 480a. DOI: 10.1016/J.Bpj.2012.11.2651  0.79
2013 Sosale N, Ivanovska II, Tsai RK, Zoltick PW, Goldman Y, Discher DE. Lentiviral Vectors Nano-Engineered with ‘Marker of Self’ CD47 to avoid Immune Surveillance Biophysical Journal. 104: 417a. DOI: 10.1016/J.Bpj.2012.11.2321  0.781
2013 Ivanovska IL, Swift J, Discher DE. Crosslinked Collagen Films Stiffen the Nucleus of Marrow Stromal Cells and Promote Osteogenesis Biophysical Journal. 104: 374a. DOI: 10.1016/J.Bpj.2012.11.2078  0.326
2013 Swift J, Pinter J, Discher DE. Cysteine-Shotgun Mass Spectrometry (CS-MS) for Probing Nuclear Lamin Conformation during Mechanical Stress Biophysical Journal. 104: 19a. DOI: 10.1016/J.Bpj.2012.11.134  0.324
2013 Discher DE. From Matrix Elasticity to Nuclear Physics in Lineage Programs Biophysical Journal. 104: 7a-8a. DOI: 10.1016/J.Bpj.2012.11.067  0.361
2013 Sancho Oltra N, Loverde SM, Harada T, Mahmud A, Rajagopal K, Discher DE. Polymersomes and filomicelles Fundamentals of Pharmaceutical Nanoscience. 183-210. DOI: 10.1007/978-1-4614-9164-4_8  0.403
2012 Raab M, Swift J, Dingal PC, Shah P, Shin JW, Discher DE. Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. The Journal of Cell Biology. 199: 669-83. PMID 23128239 DOI: 10.1083/Jcb.201205056  0.802
2012 Shin JW, Discher DE. Cell culture: Soft gels select tumorigenic cells. Nature Materials. 11: 662-3. PMID 22825018 DOI: 10.1038/Nmat3388  0.543
2012 Majkut SF, Discher DE. Cardiomyocytes from late embryos and neonates do optimal work and striate best on substrates with tissue-level elasticity: metrics and mathematics. Biomechanics and Modeling in Mechanobiology. 11: 1219-25. PMID 22752667 DOI: 10.1007/S10237-012-0413-8  0.785
2012 Sosale N, Discher DE. Marker-of-self becomes marker-of-senescence. Blood. 119: 5343-4. PMID 22679336 DOI: 10.1182/Blood-2012-04-418608  0.775
2012 Rehfeldt F, Brown AE, Raab M, Cai S, Zajac AL, Zemel A, Discher DE. Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 422-30. PMID 22344328 DOI: 10.1039/C2Ib00150K  0.803
2012 Suzuki A, Shin J, Wang Y, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS. RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy Distribution and Platelet Generation Blood. 120: 385-385. DOI: 10.1182/Blood.V120.21.385.385  0.488
2012 Shin J, Spinler KR, Swift J, Discher DE. Hierarchical Determination of Nuclear Deformability by Lamin Isoforms During Adult Hematopoiesis: Implications in Blood Cell Trafficking Blood. 120: 1200-1200. DOI: 10.1182/Blood.V120.21.1200.1200  0.769
2012 Spinler K, Shin JW, Discher DE. Platelet generation under shear force modulated by site-specific phosphorylation of myosin-IIA heavy chain 2012 38th Annual Northeast Bioengineering Conference, Nebec 2012. 217-218. DOI: 10.1182/Blood.V118.21.3262.3262  0.754
2012 Oltra NS, Loverde SM, Harada T, Mahmud A, Rajagopal K, Discher DE. Degradable poly(ethylene oxide)-blockpolycaprolactone worm-like micelles: From phase transitions and molecular simulation to persistent circulation and shrinking tumors Acs Symposium Series. 1114: 255-285. DOI: 10.1021/bk-2012-1114.ch016  0.417
2012 Spinler KR, Shin J, Discher DE. Shear-Optimized Platelet-Like-Particles From High Ploidy Mks: From Segregation to Composition and Activation Blood. 120: 3456-3456. DOI: 10.1016/J.Bpj.2012.11.806  0.761
2012 Chase BC, Pajerowski JD, Pantano D, Tang H, Speicher D, Discher D. Mapping Protein Structure Changes with Cysteine Labeling Kinetics by Mass Spectrometry Biophysical Journal. 102: 608a. DOI: 10.1016/J.Bpj.2011.11.3312  0.779
2012 Swift J, Harada T, Pinter J, Shin J, Ivanovska I, Buxbiom A, Discher DE. Lamin-A/C is a Nuclear Rheostat that Couples Microenvironment Rigidity to Cell Lineage Biophysical Journal. 102: 48a. DOI: 10.1016/J.Bpj.2011.11.293  0.647
2011 Ellenbroek WG, Wang YH, Christian DA, Discher DE, Janmey PA, Liu AJ. Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers. Biophysical Journal. 101: 2178-84. PMID 22067156 DOI: 10.1016/J.Bpj.2011.09.039  0.607
2011 Shuvaev VV, Ilies MA, Simone E, Zaitsev S, Kim Y, Cai S, Mahmud A, Dziubla T, Muro S, Discher DE, Muzykantov VR. Endothelial targeting of antibody-decorated polymeric filomicelles. Acs Nano. 5: 6991-9. PMID 21838300 DOI: 10.1021/Nn2015453  0.423
2011 Shin JW, Swift J, Spinler KR, Discher DE. Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proceedings of the National Academy of Sciences of the United States of America. 108: 11458-63. PMID 21709232 DOI: 10.1073/Pnas.1017474108  0.765
2011 Friedrich BM, Buxboim A, Discher DE, Safran SA. Striated acto-myosin fibers can reorganize and register in response to elastic interactions with the matrix. Biophysical Journal. 100: 2706-15. PMID 21641316 DOI: 10.1016/J.Bpj.2011.04.050  0.313
2011 Krieger CC, An X, Tang HY, Mohandas N, Speicher DW, Discher DE. Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 8269-74. PMID 21527722 DOI: 10.1073/Pnas.1018887108  0.314
2011 Stachelek SJ, Finley MJ, Alferiev IS, Wang F, Tsai RK, Eckells EC, Tomczyk N, Connolly JM, Discher DE, Eckmann DM, Levy RJ. The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials. 32: 4317-26. PMID 21429575 DOI: 10.1016/J.Biomaterials.2011.02.053  0.577
2011 Harada T, Discher DE. Materials science: Bubble wrap of cell-like aggregates. Nature. 471: 172-3. PMID 21390121 DOI: 10.1038/471172A  0.52
2011 Purohit PK, Litvinov RI, Brown AE, Discher DE, Weisel JW. Protein unfolding accounts for the unusual mechanical behavior of fibrin networks. Acta Biomaterialia. 7: 2374-83. PMID 21342665 DOI: 10.1016/J.Actbio.2011.02.026  0.599
2011 Sen S, Tewari M, Zajac A, Barton E, Sweeney HL, Discher DE. Upregulation of paxillin and focal adhesion signaling follows Dystroglycan Complex deletions and promotes a hypertensive state of differentiation. European Journal of Cell Biology. 90: 249-60. PMID 20663583 DOI: 10.1016/J.Ejcb.2010.06.005  0.555
2011 Shin J, Buxboim A, Discher DE. Myosin-II Is a Major Modulator of Human Hematopoietic Stem Cell Proliferation and Differentiation Blood. 118: 2343-2343. DOI: 10.1182/Blood.V118.21.2343.2343  0.538
2011 Baumann B, Dorsey J, Xu X, Harada T, Chapman C, Benci J, Jaiswal S, Mahmud A, Discher D, Kao G. ‘Breaking through the Tumor BBB’: Enhancing the Efficacy of Nanobiopolymer Therapeutics against Intracranial Tumors with Targeted Radiation Therapy International Journal of Radiation Oncology*Biology*Physics. 81: S145-S146. DOI: 10.1016/J.Ijrobp.2011.06.298  0.472
2011 Loverde SM, Pantano DA, Christian DA, Mahmud A, Klein ML, Discher DE. Curvature, rigidity, and pattern formation in functional polymer micelles and vesicles-From dynamic visualization to molecular simulation Current Opinion in Solid State and Materials Science. 15: 277-284. DOI: 10.1016/J.Cossms.2011.06.003  0.623
2011 Swift J, Harada T, Shin J, Tang H, Speicher D, Discher DE. Optimized Quantitation from Proteomic Datasets - Application to Lamin Knockdown and Isoform Modulation During Stem Cell Differentiation Biophysical Journal. 100: 50a. DOI: 10.1016/J.Bpj.2010.12.470  0.626
2011 Rodriguez PL, Harada T, Discher DE. Nanoparticles Masquerade as “Self” to Inhibit Phagocytosis Biophysical Journal. 100: 550a. DOI: 10.1016/J.Bpj.2010.12.3204  0.537
2011 Shin J, Spinler KR, Swift J, Discher DE. Differentiation of Hematopoietic Stem Cell Modulated by Actomyosin Forces Biophysical Journal. 100: 442a-443a. DOI: 10.1016/J.Bpj.2010.12.2606  0.776
2011 Ivanovska IL, Discher DE. Stem Cells Behaviour on Nano-Films of Collagen Fibrils Biophysical Journal. 100: 442a. DOI: 10.1016/J.Bpj.2010.12.2601  0.338
2011 Buxboim A, Eckels EC, Discher DE. How Deeply Cells Feel: From Soft Matrices of Controlled Thickness to Nuclear Readouts Biophysical Journal. 100: 441a-442a. DOI: 10.1016/J.Bpj.2010.12.2600  0.388
2011 Raab MD, Discher DE. Cells CRAWL from Soft to Stiff Surfaces as Myosin-II Polarizes the Cytoskeleton Biophysical Journal. 100: 441a. DOI: 10.1016/J.Bpj.2010.12.2599  0.783
2011 Sosale N, Tsai RK, Ivanovska I, Zoltick PW, Discher DE. Reducing Immune Response against Lentiviral Vectors: Lentiviral Vector Presentation of CD47, The ‘Marker of Self’ Biophysical Journal. 100: 403a. DOI: 10.1016/J.Bpj.2010.12.2393  0.778
2011 Chase BC, Pajerowski JD, Pantano D, Tang H, Speicher D, Discher D. Mapping Foldome Changes with Cysteine Labeling Kinetics Measured by Mass Spectrometry Biophysical Journal. 100: 371a. DOI: 10.1016/J.Bpj.2010.12.2211  0.776
2011 Harada T, Discher D. Effect of Nuclear Stiffness on Cell Translation In Vivo Biophysical Journal. 100: 307a. DOI: 10.1016/J.Bpj.2010.12.1875  0.582
2011 Majkut SF, Discher DE. Elasticity of Developing Cardiac Tissue and Influence on Early Cardiomyocyte Beating Biophysical Journal. 100: 296a. DOI: 10.1016/J.Bpj.2010.12.1817  0.784
2010 Christian DA, Garbuzenko OB, Minko T, Discher DE. Polymer Vesicles with a Red Cell-like Surface Charge: Microvascular Imaging and in vivo Tracking with Near-Infrared Fluorescence. Macromolecular Rapid Communications. 31: 135-41. PMID 21590885 DOI: 10.1002/Marc.200900589  0.637
2010 Rajagopal K, Mahmud A, Christian DA, Pajerowski JD, Brown AE, Loverde SM, Discher DE. Curvature-coupled hydration of Semicrystalline Polymer Amphiphiles yields flexible Worm Micelles but favors rigid Vesicles: polycaprolactone-based block copolymers. Macromolecules. 43: 9736-9746. PMID 21499509 DOI: 10.1021/Ma101316W  0.777
2010 Raab M, Shin JW, Discher DE. Matrix elasticity in vitro controls muscle stem cell fate in vivo. Stem Cell Research & Therapy. 1: 38. PMID 21144011 DOI: 10.1186/Scrt38  0.799
2010 Krieger CC, Bhasin N, Tewari M, Brown AE, Safer D, Sweeney HL, Discher DE. Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics. Cytoskeleton (Hoboken, N.J.). 67: 796-807. PMID 20886611 DOI: 10.1002/Cm.20489  0.693
2010 Ivanovska I, Swift J, Harada T, Pajerowski JD, Discher DE. Physical plasticity of the nucleus and its manipulation. Methods in Cell Biology. 98: 207-20. PMID 20816236 DOI: 10.1016/S0091-679X(10)98009-6  0.795
2010 Buxboim A, Discher DE. Stem cells feel the difference. Nature Methods. 7: 695-7. PMID 20805798 DOI: 10.1038/Nmeth0910-695  0.316
2010 Zemel A, Rehfeldt F, Brown AE, Discher DE, Safran SA. Optimal matrix rigidity for stress fiber polarization in stem cells. Nature Physics. 6: 468-473. PMID 20563235 DOI: 10.1038/Nphys1613  0.544
2010 Zemel A, Rehfeldt F, Brown AE, Discher DE, Safran SA. Cell shape, spreading symmetry and the polarization of stress-fibers in cells. Journal of Physics. Condensed Matter : An Institute of Physics Journal. 22: 194110. PMID 20458358 DOI: 10.1088/0953-8984/22/19/194110  0.573
2010 Buxboim A, Rajagopal K, Brown AE, Discher DE. How deeply cells feel: methods for thin gels. Journal of Physics. Condensed Matter : An Institute of Physics Journal. 22: 194116. PMID 20454525 DOI: 10.1088/0953-8984/22/19/194116  0.567
2010 Chaudhuri T, Rehfeldt F, Sweeney HL, Discher DE. Preparation of collagen-coated gels that maximize in vitro myogenesis of stem cells by matching the lateral elasticity of in vivo muscle. Methods in Molecular Biology (Clifton, N.J.). 621: 185-202. PMID 20405368 DOI: 10.1007/978-1-60761-063-2_13  0.341
2010 Tsai RK, Rodriguez PL, Discher DE. Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells, Molecules & Diseases. 45: 67-74. PMID 20299253 DOI: 10.1016/J.Bcmd.2010.02.016  0.56
2010 Buxboim A, Ivanovska IL, Discher DE. Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? Journal of Cell Science. 123: 297-308. PMID 20130138 DOI: 10.1242/Jcs.041186  0.409
2010 Thomas WE, Discher DE, Prasad Shastri V. Mechanical regulation of cells by materials and tissues Mrs Bulletin. 35: 578-583. DOI: 10.1557/Mrs2010.525  0.367
2010 Shin J, Spinler KR, Swift J, Discher DE. Myosin-II Plays Central Roles In Cell Life and Death Decisions During Adult Hematopoiesis. Blood. 116: 1595-1595. DOI: 10.1182/Blood.V116.21.1595.1595  0.773
2010 Rajagopal K, Christian DA, Harada T, Tian A, Discher DE. Polymersomes and wormlike micelles made fluorescent by direct modifications of block copolymer amphiphiles International Journal of Polymer Science. 2010. DOI: 10.1155/2010/379286  0.693
2010 Buxboim A, Sen S, Discher DE. How Deep Cells Feel Biophysical Journal. 98: 732a. DOI: 10.1016/J.Bpj.2009.12.4013  0.586
2010 Ivanovska IL, Discher D. Crosslinked Collagen Films Affect Cell State Biophysical Journal. 98: 731a. DOI: 10.1016/J.Bpj.2009.12.4009  0.336
2010 Discher DE, Rodriguez P, Tsai R, Hsu K. Physics of Phagocytosis in Self Recognition: Particle Size and Myosin Forces Biophysical Journal. 98: 727a. DOI: 10.1016/J.Bpj.2009.12.3988  0.575
2010 Chaudhuri T, Discher DE, Sweeney HL. A Suitably Compliant Microenvironment Commits Mesenchymal Stem Cells to Differentiate into Muscle Like Cells Which Restore Muscular Defects in Dystrophic Models Biophysical Journal. 98: 611a. DOI: 10.1016/J.Bpj.2009.12.3332  0.349
2010 Swift J, Chase BC, Pajerowski JD, Pantano D, Tang H, Speicher DW, Discher DE. Cysteine Reactivity as a Probe of the Proteome Biophysical Journal. 98: 447a. DOI: 10.1016/J.Bpj.2009.12.2431  0.766
2010 Rehfeldt F, Zajac A, Brown A, Buxboim A, Discher DE. Matrix Elasticity and Nuclear Physics Biophysical Journal. 98: 427a. DOI: 10.1016/J.Bpj.2009.12.2316  0.56
2010 Rehfeldt F, Engler AJ, Discher DE. Stem Cells and Nanomedicine: Nanomechanics of the Microenvironment Nanotechnology. 305-322. DOI: 10.1002/9783527628155.Nanotech058  0.597
2010 Cai S, Christian DA, Tewari M, Minko T, Discher DE. Anti-cancer polymersomes Rsc Nanoscience and Nanotechnology. 300-312.  0.547
2009 Sen S, Engler AJ, Discher DE. Matrix strains induced by cells: Computing how far cells can feel. Cellular and Molecular Bioengineering. 2: 39-48. PMID 20582230 DOI: 10.1007/S12195-009-0052-Z  0.693
2009 Brown AE, Discher DE. Conformational changes and signaling in cell and matrix physics. Current Biology : Cb. 19: R781-9. PMID 19906580 DOI: 10.1016/J.Cub.2009.06.054  0.552
2009 Christian DA, Tian A, Ellenbroek WG, Levental I, Rajagopal K, Janmey PA, Liu AJ, Baumgart T, Discher DE. Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nature Materials. 8: 843-9. PMID 19734886 DOI: 10.1038/Nmat2512  0.61
2009 Brown AE, Litvinov RI, Discher DE, Purohit PK, Weisel JW. Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water. Science (New York, N.Y.). 325: 741-4. PMID 19661428 DOI: 10.1126/Science.1172484  0.619
2009 Levental I, Christian DA, Wang YH, Madara JJ, Discher DE, Janmey PA. Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (PIP2)- and cholesterol-containing monolayers. Biochemistry. 48: 8241-8. PMID 19630438 DOI: 10.1021/Bi9007879  0.6
2009 Tenney RM, Discher DE. Stem cells, microenvironment mechanics, and growth factor activation. Current Opinion in Cell Biology. 21: 630-5. PMID 19615877 DOI: 10.1016/J.Ceb.2009.06.003  0.363
2009 Discher DE, Mooney DJ, Zandstra PW. Growth factors, matrices, and forces combine and control stem cells. Science (New York, N.Y.). 324: 1673-7. PMID 19556500 DOI: 10.1126/Science.1171643  0.367
2009 Brown AE, Hategan A, Safer D, Goldman YE, Discher DE. Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments. Biophysical Journal. 96: 1952-60. PMID 19254555 DOI: 10.1016/J.Bpj.2008.11.032  0.502
2009 Christian DA, Cai S, Garbuzenko OB, Harada T, Zajac AL, Minko T, Discher DE. Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage. Molecular Pharmaceutics. 6: 1343-52. PMID 19249859 DOI: 10.1021/Mp900022M  0.697
2009 Kim Y, Tewari M, Pajerowski JD, Cai S, Sen S, Williams JH, Williams J, Sirsi SR, Sirsi S, Lutz GJ, Lutz G, Discher DE. Polymersome delivery of siRNA and antisense oligonucleotides. Journal of Controlled Release : Official Journal of the Controlled Release Society. 134: 132-40. PMID 19084037 DOI: 10.1016/J.Jconrel.2008.10.020  0.782
2009 Christian DA, Cai S, Bowen DM, Kim Y, Pajerowski JD, Discher DE. Polymersome carriers: from self-assembly to siRNA and protein therapeutics. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 71: 463-74. PMID 18977437 DOI: 10.1016/J.Ejpb.2008.09.025  0.788
2009 Kim Y, Tewari M, Pajerowski JD, Cai S, Sen S, Williams JH, Sirsi SR, Lutz GJ, Discher DE. Erratum to “Polymersome delivery of siRNA and antisense oligonucleotides” Journal of Controlled Release. 137: 256. DOI: 10.1016/J.Jconrel.2009.05.001  0.76
2009 Buxboim A, Sen S, Discher DE. How deep cells feel: Mean-field Computations and Experiments Biophysical Journal. 96: 628a. DOI: 10.1016/J.Bpj.2008.12.3320  0.578
2009 Rehfeldt F, Zemel A, Brown AE, Safran SA, Discher DE. Matrix Elasticity Dictates Cytoskeletal Polarization In Mesenchymal Stem Cells Biophysical Journal. 96: 627a. DOI: 10.1016/J.Bpj.2008.12.3315  0.395
2009 Carag C, Engler A, Discher DE. Elastic Matrices that mimic normal heart are best for beating Cardiomyocytes - Beating stops on mechanical mimics of Scars Biophysical Journal. 96: 523a. DOI: 10.1016/J.Bpj.2008.12.2699  0.599
2009 Discher DE, Carag C, Chase B. A Proteomic-scale, Mass Spec-based Method to Probe Forced Unfolding within Cells Biophysical Journal. 96: 330a. DOI: 10.1016/J.Bpj.2008.12.1662  0.335
2009 Brown AE, Rehfeldt F, Zajac AL, Discher D. Stem Cell Biophysics: Pre-differentiation Dynamics of Stress Fiber Polarization on Elastic Matrices Biophysical Journal. 96: 197a. DOI: 10.1016/J.Bpj.2008.12.1054  0.342
2009 Tong R, Christian DA, Tang L, Cabral H, Baker JR, Kataoka K, Discher DE, Cheng J. Nanopolymeric therapeutics Mrs Bulletin. 34: 422-431.  0.547
2008 Engler AJ, Carag-Krieger C, Johnson CP, Raab M, Tang HY, Speicher DW, Sanger JW, Sanger JM, Discher DE. Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. Journal of Cell Science. 121: 3794-802. PMID 18957515 DOI: 10.1242/Jcs.029678  0.809
2008 Zajac AL, Discher DE. Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling. Current Opinion in Cell Biology. 20: 609-15. PMID 18926907 DOI: 10.1016/J.Ceb.2008.09.006  0.379
2008 Tsai R, Rodriguez P, Discher DE. Cys shotgun labeling of macrophages adhering to and engulfing Ig-opsonized cells. Transfusion Clinique Et Biologique : Journal De La SociéTé FrançAise De Transfusion Sanguine. 15: 58-61. PMID 18499497 DOI: 10.1016/J.Tracli.2008.04.011  0.595
2008 Tsai RK, Discher DE. Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. The Journal of Cell Biology. 180: 989-1003. PMID 18332220 DOI: 10.1083/Jcb.200708043  0.579
2008 Brown AE, Litvinov RI, Purohit P, Discher DE, Weisel J. Multiscale Mechanics of Fibrin Clots Blood. 112: 3089-3089. DOI: 10.1182/Blood.V112.11.3089.3089  0.497
2008 Harada T, Rajagopal K, Discher DE. Cell uptake of morphologically distinct polymer micelles Aiche Annual Meeting, Conference Proceedings.  0.465
2008 Rajagopal K, Pajerowski JD, Discher DE. Supramolecular morphologies from polyethyleneoxide-B-polycaprolactone diblock copolymers and effect of nanoscale confinement on polycaprolactone crystallization Aiche Annual Meeting, Conference Proceedings.  0.735
2008 Christian DA, Bowen DM, Dunn RJ, Discher DE. Anionic nano-polymersomes for enhanced circulation kinetics in vivo Aiche Annual Meeting, Conference Proceedings.  0.568
2008 Pajerowski JD, Rajagopal K, Discher DE. Solution studies of protein folding using a site-specific probe of cysteine accessibility Aiche Annual Meeting, Conference Proceedings.  0.737
2008 Christian DA, Rajagopal K, Srinivas G, Klein ML, Discher DE. Nanoparticle incorporation and aggregation in block copolymer worm-like micelles Aiche Annual Meeting, Conference Proceedings.  0.55
2008 Tsai R, Rodriguez P, Discher DE. 'Marker of Self' proteins on synthetics- Exploiting the body's own system of distinguishing foreign from self Aiche Annual Meeting, Conference Proceedings.  0.479
2007 Photos PJ, Bermudez H, Aranda-Espinoza H, Shillcock J, Discher DE. Nuclear pores and membrane holes: generic models for confined chains and entropic barriers in pore stabilization. Soft Matter. 3: 364-371. PMID 32900153 DOI: 10.1039/B611412C  0.79
2007 Discher DE, Ortiz V, Srinivas G, Klein ML, Kim Y, Christian D, Cai S, Photos P, Ahmed F. Emerging Applications of Polymersomes in Delivery: from Molecular Dynamics to Shrinkage of Tumors. Progress in Polymer Science. 32: 838-857. PMID 24692840 DOI: 10.1016/J.Progpolymsci.2007.05.011  0.78
2007 Geng Y, Dalhaimer P, Cai S, Tsai R, Tewari M, Minko T, Discher DE. Shape effects of filaments versus spherical particles in flow and drug delivery. Nature Nanotechnology. 2: 249-55. PMID 18654271 DOI: 10.1038/Nnano.2007.70  0.763
2007 Engler AJ, Sweeney HL, Discher DE, Schwarzbauer JE. Extracellular matrix elasticity directs stem cell differentiation. Journal of Musculoskeletal & Neuronal Interactions. 7: 335. PMID 18094500  0.65
2007 Rehfeldt F, Engler AJ, Eckhardt A, Ahmed F, Discher DE. Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Advanced Drug Delivery Reviews. 59: 1329-39. PMID 17900747 DOI: 10.1016/J.Addr.2007.08.007  0.719
2007 Pajerowski JD, Dahl KN, Zhong FL, Sammak PJ, Discher DE. Physical plasticity of the nucleus in stem cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 104: 15619-24. PMID 17893336 DOI: 10.1073/Pnas.0702576104  0.8
2007 Johnson CP, Tang HY, Carag C, Speicher DW, Discher DE. Forced unfolding of proteins within cells. Science (New York, N.Y.). 317: 663-6. PMID 17673662 DOI: 10.1126/Science.1139857  0.349
2007 Engler AJ, Rehfeldt F, Sen S, Discher DE. Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation. Methods in Cell Biology. 83: 521-45. PMID 17613323 DOI: 10.1016/S0091-679X(07)83022-6  0.685
2007 Lammerding J, Dahl KN, Discher DE, Kamm RD. Nuclear mechanics and methods. Methods in Cell Biology. 83: 269-94. PMID 17613312 DOI: 10.1016/S0091-679X(07)83011-1  0.604
2007 Frey MT, Engler A, Discher DE, Lee J, Wang YL. Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy. Methods in Cell Biology. 83: 47-65. PMID 17613304 DOI: 10.1016/S0091-679X(07)83003-2  0.57
2007 Cai S, Vijayan K, Cheng D, Lima EM, Discher DE. Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharmaceutical Research. 24: 2099-109. PMID 17564817 DOI: 10.1007/S11095-007-9335-Z  0.579
2007 Johnson CP, Gaetani M, Ortiz V, Bhasin N, Harper S, Gallagher PG, Speicher DW, Discher DE. Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding. Blood. 109: 3538-43. PMID 17192394 DOI: 10.1182/Blood-2006-07-038588  0.599
2007 Brown AE, Litvinov RI, Discher DE, Weisel JW. Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM. Biophysical Journal. 92: L39-41. PMID 17172299 DOI: 10.1529/Biophysj.106.101261  0.604
2007 Subramanian S, Boder ET, Discher DE. Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site. The Journal of Biological Chemistry. 282: 1805-18. PMID 17098740 DOI: 10.1074/Jbc.M603923200  0.542
2007 Photos PJ, Bermudez H, Aranda-Espinoza H, Shillcock J, Discher DE. Nuclear pores and membrane holes: Generic models for confined chains and entropic barriers in pore stabilization Soft Matter. 3: 364-371. DOI: 10.1039/b611412c  0.769
2007 Rehfeldt F, Discher DE. Biophysics: Cell dipoles feel their way Nature Physics. 3: 592-593. DOI: 10.1038/Nphys712  0.352
2007 Dalhaimer P, Discher DE, Lubensky TC. Crosslinked actin networks show liquid crystal elastomer behaviour, including soft-mode elasticity Nature Physics. 3: 354-360. DOI: 10.1038/Nphys567  0.668
2007 Subramanian S, Tsai R, Sen S, Dahl KN, Discher DE. Erratum to “Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)—Major differences between mouse and man and implications for signaling” [Blood Cells Mol. Dis. 36 (2006) 364–372] Blood Cells, Molecules, and Diseases. 38: 66-67. DOI: 10.1016/J.Bcmd.2006.01.014  0.781
2006 Kim Y, Tewari M, Pajeroski DJ, Sen S, Jason W, Sirsi S, Lutz G, Discher DE. Efficient nuclear delivery and nuclear body localization of antisense oligo-nucleotides using degradable polymersomes. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 4350-3. PMID 17947079 DOI: 10.1109/IEMBS.2006.259861  0.555
2006 Ahmed F, Pakunlu RI, Brannan A, Bates F, Minko T, Discher DE. Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. Journal of Controlled Release : Official Journal of the Controlled Release Society. 116: 150-8. PMID 16942814 DOI: 10.1016/J.Jconrel.2006.07.012  0.538
2006 Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 126: 677-89. PMID 16923388 DOI: 10.1016/J.Cell.2006.06.044  0.689
2006 Discher DE, Ahmed F. Polymersomes. Annual Review of Biomedical Engineering. 8: 323-41. PMID 16834559 DOI: 10.1146/annurev.bioeng.8.061505.095838  0.498
2006 Ahmed F, Pakunlu RI, Srinivas G, Brannan A, Bates F, Klein ML, Minko T, Discher DE. Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation. Molecular Pharmaceutics. 3: 340-50. PMID 16749866 DOI: 10.1021/Mp050103U  0.551
2006 Subramanian S, Tsai R, Sen S, Dahl KN, Discher DE. Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling. Blood Cells, Molecules & Diseases. 36: 364-72. PMID 16697668 DOI: 10.1016/J.Bcmd.2006.01.012  0.788
2006 Discher DE, Bhasin N, Johnson CP. Covalent chemistry on distended proteins. Proceedings of the National Academy of Sciences of the United States of America. 103: 7533-4. PMID 16682625 DOI: 10.1073/Pnas.0602388103  0.611
2006 Brown AG, Leite RS, Engler AJ, Discher DE, Strauss JF. A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells. Peptides. 27: 1794-800. PMID 16621150 DOI: 10.1016/J.Peptides.2006.03.015  0.516
2006 Subramanian S, Tsai R, Discher DE. The 'metabolon,' CD47, and the 'phagocytic synapse': molecular co-localization and species divergence. Transfusion Clinique Et Biologique : Journal De La SociéTé FrançAise De Transfusion Sanguine. 13: 31-8. PMID 16581280 DOI: 10.1016/J.Tracli.2006.02.009  0.658
2006 Vijayan K, Geng Y, Discher D. Electric field manipulation of charged copolymer worm micelles. The Journal of Physical Chemistry. B. 110: 3831-4. PMID 16494443 DOI: 10.1021/Jp055276D  0.525
2006 An X, Guo X, Zhang X, Baines AJ, Debnath G, Moyo D, Salomao M, Bhasin N, Johnson C, Discher D, Gratzer WB, Mohandas N. Conformational stabilities of the structural repeats of erythroid spectrin and their functional implications. The Journal of Biological Chemistry. 281: 10527-32. PMID 16476728 DOI: 10.1074/Jbc.M513725200  0.627
2006 Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. American Journal of Physiology. Heart and Circulatory Physiology. 290: H2196-203. PMID 16473959 DOI: 10.1152/Ajpheart.01017.2005  0.534
2006 Subramanian S, Parthasarathy R, Sen S, Boder ET, Discher DE. Species- and cell type-specific interactions between CD47 and human SIRPalpha. Blood. 107: 2548-56. PMID 16291597 DOI: 10.1182/Blood-2005-04-1463  0.648
2006 Parthasarathy R, Subramanian S, Boder ET, Discher DE. Post-translational regulation of expression and conformation of an immunoglobulin domain in yeast surface display. Biotechnology and Bioengineering. 93: 159-68. PMID 16161151 DOI: 10.1002/Bit.20684  0.526
2006 Sen S, Engler A, Discher D. Cells feel matrix stiffness—Simple models and computational insights Journal of Biomechanics. 39: S398. DOI: 10.1016/S0021-9290(06)84610-5  0.647
2006 Engler A, Sen S, Discher D. Matrix elasticity directs stem cell differentiation Journal of Biomechanics. 39: S269. DOI: 10.1016/S0021-9290(06)84031-5  0.664
2006 Pajerowski D, Dahl K, Discher D. Nuclear plasticity—mechanical and supramolecular insights into the genome Journal of Biomechanics. 39: S232. DOI: 10.1016/S0021-9290(06)83860-1  0.542
2006 Vijayan K, Discher DE. Block copolymer worm micelles in dilution: Mechanochemical metrics of robustness as a basis for novel linear assemblies Journal of Polymer Science, Part B: Polymer Physics. 44: 3431-3433. DOI: 10.1002/Polb.21001  0.549
2006 Ahmed F, Photos PJ, Discher DE. Polymersomes as viral capsid mimics Drug Development Research. 67: 4-14. DOI: 10.1002/Ddr.20062  0.78
2005 Kim Y, Dalhaimer P, Christian DA, Discher DE. Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology. 16: S484-91. PMID 21727469 DOI: 10.1088/0957-4484/16/7/024  0.779
2005 Vijayan K, Discher DE, Lal J, Janmey P, Goulian M. Interactions of membrane-active peptides with thick, neutral, nonzwitterionic bilayers. The Journal of Physical Chemistry. B. 109: 14356-64. PMID 16852806 DOI: 10.1021/Jp050060X  0.549
2005 Geng Y, Ahmed F, Bhasin N, Discher DE. Visualizing worm micelle dynamics and phase transitions of a charged diblock copolymer in water. The Journal of Physical Chemistry. B. 109: 3772-9. PMID 16851424 DOI: 10.1021/Jp0459559  0.699
2005 Discher DE, Janmey P, Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science (New York, N.Y.). 310: 1139-43. PMID 16293750 DOI: 10.1126/Science.1116995  0.396
2005 Bhasin N, Law R, Liao G, Safer D, Ellmer J, Discher BM, Sweeney HL, Discher DE. Molecular extensibility of mini-dystrophins and a dystrophin rod construct. Journal of Molecular Biology. 352: 795-806. PMID 16139300 DOI: 10.1016/J.Jmb.2005.07.064  0.684
2005 Sen S, Subramanian S, Discher DE. Indentation and adhesive probing of a cell membrane with AFM: theoretical model and experiments. Biophysical Journal. 89: 3203-13. PMID 16113121 DOI: 10.1529/Biophysj.105.063826  0.64
2005 Dahl KN, Engler AJ, Pajerowski JD, Discher DE. Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophysical Journal. 89: 2855-64. PMID 16055543 DOI: 10.1529/Biophysj.105.062554  0.79
2005 Griffin MA, Feng H, Tewari M, Acosta P, Kawana M, Sweeney HL, Discher DE. gamma-Sarcoglycan deficiency increases cell contractility, apoptosis and MAPK pathway activation but does not affect adhesion. Journal of Cell Science. 118: 1405-16. PMID 15769854 DOI: 10.1242/Jcs.01717  0.624
2005 Dalhaimer P, Wagner OI, Leterrier JF, Janmey PA, Aranda-Espinoza H, Discher DE. Flexibility transitions and looped adsorption of wormlike chains Journal of Polymer Science, Part B: Polymer Physics. 43: 280-286. DOI: 10.1002/Polb.20332  0.682
2005 Subramanian S, Boder ET, Discher DE. Pleiotropic responses mediated by Cd47-Sirp□ binding: Adhesion as a common link Aiche Annual Meeting, Conference Proceedings. 8764.  0.435
2005 Ahmed F, Subramanian S, Tewari M, Discher DE. Targeting Cd47 as an apoptotic trigger of human lung carcinoma tumors Aiche Annual Meeting, Conference Proceedings. 9139.  0.597
2005 Engler AJ, Eckhardt A, Richert L, Picart C, Discher DE. Determining molecular length scales: Correlating cell spreading on nano-thin gels and films and tissue elasticity Proceedings of the 2005 Summer Bioengineering Conference. 2005: 471-472.  0.494
2005 Engler AJ, Berry MF, Sweeney HL, Discher DE. Substrate stiffness directs mesenchymal stem cell differentiation Proceedings of the 2005 Summer Bioengineering Conference. 2005: 311-312.  0.504
2005 Engler A, Discher DE. Substrate softness directs differentiation of human stem cells Aiche Annual Meeting, Conference Proceedings. 8828.  0.5
2005 Ahmed F, Srinivas G, Brannan A, Klein ML, Bates FS, Discher DE. Breaking down endolysosomal barriers for drug delivery with degradable polymersomes Aiche Annual Meeting, Conference Proceedings. 14294.  0.449
2005 Dalhaimer P, Geng Y, Photos PJ, Fyfe B, Tewari M, Discher DE. Long-circulating cylinder micelles demonstrate strong effects of morphology on biological transport Aiche Annual Meeting, Conference Proceedings. 14256.  0.765
2005 Ahmed F, Pakunlu RI, Srinivas G, Klein ML, Minko T, Discher DE. Degradable polymersomes that create new pathways for anti-cancer drugs Aiche Annual Meeting, Conference Proceedings. 14292.  0.453
2004 Pata V, Ahmed F, Discher DE, Dant N. Membrane solubilization by detergent: resistance conferred by thickness. Langmuir : the Acs Journal of Surfaces and Colloids. 20: 3888-93. PMID 15969375 DOI: 10.1021/La035734E  0.532
2004 Bermúdez H, Hammer DA, Discher DE. Effect of bilayer thickness on membrane bending rigidity. Langmuir : the Acs Journal of Surfaces and Colloids. 20: 540-3. PMID 15773070 DOI: 10.1021/la035497f  0.653
2004 Griffin MA, Sen S, Sweeney HL, Discher DE. Adhesion-contractile balance in myocyte differentiation. Journal of Cell Science. 117: 5855-63. PMID 15522893 DOI: 10.1242/Jcs.01496  0.709
2004 Janmey PA, Discher DE. Developmental biology: holding it together in the eye. Nature. 431: 635-6. PMID 15470408 DOI: 10.1038/431635A  0.306
2004 Engler AJ, Griffin MA, Sen S, Bönnemann CG, Sweeney HL, Discher DE. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. The Journal of Cell Biology. 166: 877-87. PMID 15364962 DOI: 10.1083/Jcb.200405004  0.767
2004 Richert L, Engler AJ, Discher DE, Picart C. Elasticity of native and cross-linked polyelectrolyte multilayer films. Biomacromolecules. 5: 1908-16. PMID 15360305 DOI: 10.1021/Bm0498023  0.507
2004 Dalhaimer P, Engler AJ, Parthasarathy R, Discher DE. Targeted worm micelles. Biomacromolecules. 5: 1714-9. PMID 15360279 DOI: 10.1021/Bm049884V  0.758
2004 Hategan A, Sengupta K, Kahn S, Sackmann E, Discher DE. Topographical pattern dynamics in passive adhesion of cell membranes Biophysical Journal. 87: 3547-3560. PMID 15339814 DOI: 10.1529/Biophysj.104.041475  0.309
2004 Dahl KN, Kahn SM, Wilson KL, Discher DE. The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. Journal of Cell Science. 117: 4779-86. PMID 15331638 DOI: 10.1242/Jcs.01357  0.631
2004 Bhasin N, Carl P, Harper S, Feng G, Lu H, Speicher DW, Discher DE. Chemistry on a single protein, vascular cell adhesion molecule-1, during forced unfolding. The Journal of Biological Chemistry. 279: 45865-74. PMID 15308645 DOI: 10.1074/Jbc.M404103200  0.642
2004 Dogic Z, Zhang J, Lau AWC, Aranda-Espinoza H, Dalhaimer P, Discher DE, Janmey PA, Kamien RD, Lubensky TC, Yodh AG. Elongation and fluctuations of semiflexible polymers in a nematic solvent Physical Review Letters. 92: 125503-1. PMID 15089684 DOI: 10.1103/Physrevlett.92.125503  0.679
2004 Ahmed F, Discher DE. Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 96: 37-53. PMID 15063028 DOI: 10.1016/J.Jconrel.2003.12.021  0.538
2004 Law R, Harper S, Speicher DW, Discher DE. Influence of lateral association on forced unfolding of antiparallel spectrin heterodimers. The Journal of Biological Chemistry. 279: 16410-6. PMID 14761982 DOI: 10.1074/Jbc.M313107200  0.491
2004 Griffin MA, Engler AJ, Barber TA, Healy KE, Sweeney HL, Discher DE. Patterning, prestress, and peeling dynamics of myocytes. Biophysical Journal. 86: 1209-22. PMID 14747355 DOI: 10.1016/S0006-3495(04)74195-8  0.71
2004 Engler A, Bacakova L, Newman C, Hategan A, Griffin M, Discher D. Substrate Compliance versus Ligand Density in Cell on Gel Responses Biophysical Journal. 86: 617-628. PMID 14695306 DOI: 10.1016/S0006-3495(04)74140-5  0.722
2004 Dahl KN, Parthasarathy R, Westhoff CM, Layton DM, Discher DE. Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells. Blood. 103: 1131-6. PMID 14551146 DOI: 10.1182/Blood-2003-04-1331  0.632
2004 Dogic Z, Zhang J, Lau AWC, Aranda-Espinoza H, Dalhaimer P, Discher DE, Janmey PA, Kamien RD, Lubensky TC, Yodh AG. Erratum: Elongation and Fluctuations of Semiflexible Polymers in a Nematic Solvent [Phys. Rev. Lett.92, 125503 (2004)] Physical Review Letters. 93. DOI: 10.1103/Physrevlett.93.219902  0.674
2004 Engler AJ, Richert L, Wong JY, Picart C, Discher DE. Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: Correlations between substrate stiffness and cell adhesion Surface Science. 570: 142-154. DOI: 10.1016/J.Susc.2004.06.179  0.576
2004 Dalhaimer P, Bermudez H, Discher DE. Biopolymer mimicry with polymeric wormlike micelles: Molecular weight scaled flexibility, locked-in curvature, and coexisting microphases Journal of Polymer Science, Part B: Polymer Physics. 42: 168-176. DOI: 10.1002/Polb.10709  0.781
2003 Law R, Liao G, Harper S, Yang G, Speicher DW, Discher DE. Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains. Biophysical Journal. 85: 3286-93. PMID 14581229 DOI: 10.1016/S0006-3495(03)74747-X  0.5
2003 Hategan A, Law R, Kahn S, Discher DE. Adhesively-tensed cell membranes: lysis kinetics and atomic force microscopy probing. Biophysical Journal. 85: 2746-59. PMID 14507737 DOI: 10.1016/S0006-3495(03)74697-9  0.533
2003 Photos PJ, Bacakova L, Discher B, Bates FS, Discher DE. Polymer vesicles in vivo: correlations with PEG molecular weight. Journal of Controlled Release : Official Journal of the Controlled Release Society. 90: 323-34. PMID 12880699 DOI: 10.1016/S0168-3659(03)00201-3  0.78
2003 Law R, Carl P, Harper S, Dalhaimer P, Speicher DW, Discher DE. Cooperativity in forced unfolding of tandem spectrin repeats. Biophysical Journal. 84: 533-44. PMID 12524305 DOI: 10.1016/S0006-3495(03)74872-3  0.746
2003 Dahl KN, Westhoff CM, Discher DE. Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual colocalization with Rh protein complexes. Blood. 101: 1194-9. PMID 12393442 DOI: 10.1182/Blood-2002-04-1187  0.616
2003 Bermúdez H, Aranda-Espinoza H, Hammer DA, Discher DE. Pore stability and dynamics in polymer membranes Europhysics Letters. 64: 550-556. DOI: 10.1209/Epl/I2003-00264-2  0.682
2003 Pata V, Dan N, Photos PJ, Discher DE. Protein adsorption into polymersomes: Effect of chain length on circulation time in vivo Bioengineering, Proceedings of the Northeast Conference. 301-302. DOI: 10.1109/NEBC.2003.1216115  0.763
2003 Dalhaimer P, Bates FS, Discher DE. Single molecule visualization of stable, stiffness-tunable, flow-conforming worm micelles Macromolecules. 36: 6873-6877. DOI: 10.1021/Ma034120D  0.695
2003 Dalhaimer P, Bates FS, Aranda-Espinoza H, Discher D. Synthetic cell elements from block copolymers - Hydrodynamic aspects Comptes Rendus Physique. 4: 251-258. DOI: 10.1016/S1631-0705(03)00028-8  0.717
2002 Popescu AL, Law RJ, Discher DE. Imaging unfixed cell membranes by atomic force microscopy Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2002: 169-170. DOI: 10.1109/NEBC.2002.999519  0.439
2002 Bermudez H, Brannan AK, Hammer DA, Bates FS, Discher DE. Molecular weight dependence of polymersome membrane structure, elasticity, and stability Macromolecules. 35: 8203-8208. DOI: 10.1021/Ma020669L  0.685
2002 Santore MM, Discher DE, Won YY, Bates FS, Hammer DA. Effect of surfactant on unilamellar polymeric vesicles: Altered membrane properties and stability in the limit of weak surfactant partitioning Langmuir. 18: 7299-7308. DOI: 10.1021/La0201319  0.473
2002 Lee JCM, Law RJ, Discher DE. Bending contributions to hydration of phospholipid and block copolymer membranes: Unifying correlations between probe fluorescence and vesicle thermoelasticity Langmuir. 17: 3592-3597. DOI: 10.1021/La001678V  0.501
2002 Discher BM, Bermudez H, Hammer DA, Discher DE, Won Yy, Bates FS. Cross-linked polymersome membranes: Vesicles with broadly adjustable properties Journal of Physical Chemistry B. 106: 2848-2854. DOI: 10.1021/Jp011958Z  0.681
2002 Ahmed F, Photos PJ, Osmaswa I, Bates FS, Discher DE. Controlled release and stealthy circulation of polymersomes Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 466-467.  0.755
2002 Dahl KN, Photos PJ, Parthasarathy R, Westhoff CM, Boder ET, Discher DE. "Marker of self" CD47: From erythrocyte to drug delivery Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 606-607.  0.77
2002 Engler A, Newman C, Hategan A, Sheehan M, Discher D. Cells on gels: Smooth and skeletal muscle cell responses to substrate compliance Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 402-403.  0.499
2002 Dahl KN, Kahn SM, Discher DE. Micromechanical properties of isolated nuclei and nuclear components Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 302-303.  0.54
2002 Law RJ, Carl P, Harper S, Dalhaimer P, Speicer D, Discher DE. Low force cooperativity in the extensible unfolding of cytoskeletal proteins Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 1: 599-600.  0.423
2001 Lee JC, Discher DE. Deformation-enhanced fluctuations in the red cell skeleton with theoretical relations to elasticity, connectivity, and spectrin unfolding. Biophysical Journal. 81: 3178-92. PMID 11720984 DOI: 10.1016/S0006-3495(01)75954-1  0.454
2001 Aranda-Espinoza H, Bermudez H, Bates FS, Discher DE. Electromechanical limits of polymersomes. Physical Review Letters. 87: 208301. PMID 11690515 DOI: 10.1103/Physrevlett.87.208301  0.605
2001 Lee JC, Discher DE. Deformation-Enhanced Fluctuations of the Erythrocyte's Spectrin-Actin Nodes and Relation to Single Molecule Measures of Spectrin Unfolding. Cellular & Molecular Biology Letters. 6: 217. PMID 11544669  0.313
2001 Lee JC, Bermudez H, Discher BM, Sheehan MA, Won YY, Bates FS, Discher DE. Preparation, stability, and in vitro performance of vesicles made with diblock copolymers. Biotechnology and Bioengineering. 73: 135-45. PMID 11255161 DOI: 10.1002/Bit.1045  0.676
2000 Picart C, Dalhaimer P, Discher DE. Actin protofilament orientation in deformation of the erythrocyte membrane skeleton. Biophysical Journal. 79: 2987-3000. PMID 11106606 DOI: 10.1016/S0006-3495(00)76535-0  0.692
2000 Discher BM, Hammer DA, Bates FS, Discher DE. Polymer vesicles in various media Current Opinion in Colloid & Interface Science. 5: 125-131. DOI: 10.1016/S1359-0294(00)00045-5  0.484
1999 Lee JC, Wong DT, Discher DE. Direct measures of large, anisotropic strains in deformation of the erythrocyte cytoskeleton. Biophysical Journal. 77: 853-64. PMID 10423431 DOI: 10.1016/S0006-3495(99)76937-7  0.458
1999 Discher BM, Won YY, Ege DS, Lee JC, Bates FS, Discher DE, Hammer DA. Polymersomes: tough vesicles made from diblock copolymers. Science (New York, N.Y.). 284: 1143-6. PMID 10325219 DOI: 10.1126/Science.284.5417.1143  0.476
1996 Kuypers FA, Lewis RA, Hua M, Schott MA, Discher D, Ernst JD, Lubin BH. Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V. Blood. 87: 1179-87. PMID 8562945 DOI: 10.1182/Blood.V87.3.1179.Bloodjournal8731179  0.332
1994 Discher DE, Mohandas N, Evans EA. Molecular maps of red cell deformation: hidden elasticity and in situ connectivity. Science (New York, N.Y.). 266: 1032-5. PMID 7973655 DOI: 10.1126/Science.7973655  0.554
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