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Peter A. Edwards, Ph.D. - Publications

Affiliations: 
1975- Biological chemistry University of California, Los Angeles, Los Angeles, CA 
Area:
Molecular Biology, Biochemistry
Website:
http://www.biolchem.ucla.edu/people/faculty/peter-edwards
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101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, ... ... Edwards PA, et al. FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metabolism. PMID 34270928 DOI: 10.1016/j.cmet.2021.06.012  0.33
2021 von Scheidt M, Zhao Y, de Aguiar Vallim TQ, Che N, Wierer M, Seldin MM, Franzén O, Kurt Z, Pang S, Bongiovanni D, Yamamoto M, Edwards PA, Ruusalepp A, Kovacic JC, Mann M, et al. The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation. PMID 33626882 DOI: 10.1161/CIRCULATIONAHA.120.050186  0.317
2018 Von Scheidt M, Zhao Y, De Aguiar Vallim TQ, Che N, Franzen O, Kurt Z, Yamamoto M, Edwards PA, Ruusalepp A, Kovacic J, Bjorkegren JLM, Lusis AJ, Yang X, Schunkert H. P1844The transcription factor MAFF regulates an atherosclerosis relevant gene network European Heart Journal. 39. DOI: 10.1093/Eurheartj/Ehy565.P1844  0.332
2016 Tarling EJ, Edwards PA. Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27230131 DOI: 10.1161/Atvbaha.116.307414  0.305
2015 de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metabolism. 21: 298-310. PMID 25651182 DOI: 10.1016/J.Cmet.2015.01.007  0.457
2014 Das S, Edwards PA, Crockett JC, Rogers MJ. Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. Biochimica Et Biophysica Acta. 1841: 569-73. PMID 24369118 DOI: 10.1016/J.Bbalip.2013.12.010  0.32
2013 Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metabolism. 18: 685-97. PMID 24206663 DOI: 10.1016/J.Cmet.2013.10.002  0.409
2013 de Aguiar Vallim TQ, Tarling EJ, Edwards PA. Pleiotropic roles of bile acids in metabolism. Cell Metabolism. 17: 657-69. PMID 23602448 DOI: 10.1016/J.Cmet.2013.03.013  0.479
2013 Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, et al. Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metabolism. 17: 549-61. PMID 23562078 DOI: 10.1016/J.Cmet.2013.03.009  0.628
2013 de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circulation Research. 112: 1602-12. PMID 23519696 DOI: 10.1161/Circresaha.112.300648  0.696
2013 Tarling EJ, de Aguiar Vallim TQ, Edwards PA. Role of ABC transporters in lipid transport and human disease. Trends in Endocrinology and Metabolism: Tem. 24: 342-50. PMID 23415156 DOI: 10.1016/J.Tem.2013.01.006  0.389
2013 Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metabolism. 17: 49-60. PMID 23312283 DOI: 10.1016/J.Cmet.2012.12.011  0.416
2012 Zhang Y, Ge X, Heemstra LA, Chen WD, Xu J, Smith JL, Ma H, Kasim N, Edwards PA, Novak CM. Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice. Molecular Endocrinology (Baltimore, Md.). 26: 272-80. PMID 22261820 DOI: 10.1210/Me.2011-1157  0.346
2012 Tarling EJ, Edwards PA. Dancing with the sterols: critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis. Biochimica Et Biophysica Acta. 1821: 386-95. PMID 21824529 DOI: 10.1016/J.Bbalip.2011.07.011  0.423
2011 Tarling EJ, Edwards PA. ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proceedings of the National Academy of Sciences of the United States of America. 108: 19719-24. PMID 22095132 DOI: 10.1073/Pnas.1113021108  0.4
2011 Yin L, Ma H, Ge X, Edwards PA, Zhang Y. Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 328-36. PMID 21071704 DOI: 10.1161/Atvbaha.110.217828  0.353
2010 Jiang YJ, Lu B, Tarling EJ, Kim P, Man MQ, Crumrine D, Edwards PA, Elias PM, Feingold KR. Regulation of ABCG1 expression in human keratinocytes and murine epidermis. Journal of Lipid Research. 51: 3185-95. PMID 20675829 DOI: 10.1194/Jlr.M006445  0.498
2010 Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA. Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Molecular Endocrinology (Baltimore, Md.). 24: 1626-36. PMID 20573685 DOI: 10.1210/Me.2010-0117  0.698
2010 Chong HK, Infante AM, Seo YK, Jeon TI, Zhang Y, Edwards PA, Xie X, Osborne TF. Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1. Nucleic Acids Research. 38: 6007-17. PMID 20483916 DOI: 10.1093/Nar/Gkq397  0.459
2010 Tarling EJ, Bojanic DD, Tangirala RK, Wang X, Lovgren-Sandblom A, Lusis AJ, Bjorkhem I, Edwards PA. Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1174-80. PMID 20299684 DOI: 10.1161/Atvbaha.110.205617  0.772
2010 Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA. Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. The Journal of Biological Chemistry. 285: 3035-43. PMID 19996107 DOI: 10.1074/Jbc.M109.083899  0.52
2010 Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lövgren-Sandblom A, Björkhem I, Edwards PA. Differential expression and function of ABCG1 and ABCG4 during development and aging. Journal of Lipid Research. 51: 169-81. PMID 19633360 DOI: 10.1194/Jlr.M900250-Jlr200  0.799
2010 Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA. Activation of the Farnesoid X-Activated Receptor Provides Protection against Acetaminophen-Induced Hepatic Toxicity The Journal of Clinical Endocrinology & Metabolism. 95: 3563-3563. DOI: 10.1210/Jcem.95.7.9994  0.698
2009 Vallim TQ, Edwards PA. Bile acids have the gall to function as hormones. Cell Metabolism. 10: 162-4. PMID 19723491 DOI: 10.1016/J.Cmet.2009.08.005  0.371
2009 A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 31: 245-58. PMID 19646905 DOI: 10.1016/J.Immuni.2009.06.018  0.717
2009 Tarr PT, Tarling EJ, Bojanic DD, Edwards PA, Baldán A. Emerging new paradigms for ABCG transporters. Biochimica Et Biophysica Acta. 1791: 584-93. PMID 19416657 DOI: 10.1016/J.Bbalip.2009.01.007  0.752
2009 Baldán A, Bojanic DD, Edwards PA. The ABCs of sterol transport. Journal of Lipid Research. 50: S80-5. PMID 18997165 DOI: 10.1194/Jlr.R800044-Jlr200  0.829
2008 Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 134: 97-111. PMID 18614014 DOI: 10.1016/J.Cell.2008.04.052  0.727
2008 Baldán A, Gomes AV, Ping P, Edwards PA. Loss of ABCG1 results in chronic pulmonary inflammation. Journal of Immunology (Baltimore, Md. : 1950). 180: 3560-8. PMID 18292583 DOI: 10.4049/Jimmunol.180.5.3560  0.659
2008 Zhang Y, Edwards PA. FXR signaling in metabolic disease. Febs Letters. 582: 10-8. PMID 18023284 DOI: 10.1016/J.Febslet.2007.11.015  0.411
2008 Tarr PT, Edwards PA. ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. Journal of Lipid Research. 49: 169-82. PMID 17916878 DOI: 10.1194/Jlr.M700364-Jlr200  0.763
2007 Lee H, Hubbert ML, Osborne TF, Woodford K, Zerangue N, Edwards PA. Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha. The Journal of Biological Chemistry. 282: 21653-61. PMID 17545158 DOI: 10.1074/Jbc.M700897200  0.461
2007 Hubbert ML, Zhang Y, Lee FY, Edwards PA. Regulation of hepatic Insig-2 by the farnesoid X receptor. Molecular Endocrinology (Baltimore, Md.). 21: 1359-69. PMID 17440045 DOI: 10.1210/Me.2007-0089  0.71
2006 Lee FY, Lee H, Hubbert ML, Edwards PA, Zhang Y. FXR, a multipurpose nuclear receptor. Trends in Biochemical Sciences. 31: 572-80. PMID 16908160 DOI: 10.1016/J.Tibs.2006.08.002  0.66
2006 Baldán A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2301-7. PMID 16888235 DOI: 10.1161/01.Atv.0000240051.22944.Dc  0.78
2006 Baldán A, Tarr P, Vales CS, Frank J, Shimotake TK, Hawgood S, Edwards PA. Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis. The Journal of Biological Chemistry. 281: 29401-10. PMID 16887795 DOI: 10.1074/Jbc.M606597200  0.799
2006 Zhang Y, Wang X, Vales C, Lee FY, Lee H, Lusis AJ, Edwards PA. FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2316-21. PMID 16825595 DOI: 10.1161/01.Atv.0000235697.35431.05  0.602
2006 Baldán A, Tarr P, Lee R, Edwards PA. ATP-binding cassette transporter G1 and lipid homeostasis. Current Opinion in Lipidology. 17: 227-32. PMID 16680026 DOI: 10.1097/01.Mol.0000226113.89812.Bb  0.778
2006 Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, Edwards PA. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 1006-11. PMID 16410358 DOI: 10.1073/Pnas.0506982103  0.631
2006 Shih DM, Kast-Woelbern HR, Wong J, Xia YR, Edwards PA, Lusis AJ. A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. Journal of Lipid Research. 47: 384-92. PMID 16269825 DOI: 10.1194/Jlr.M500378-Jlr200  0.497
2006 Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. Journal of Lipid Research. 47: 201-14. PMID 16251721 DOI: 10.1194/Jlr.M500417-Jlr200  0.669
2005 Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metabolism. 1: 201-13. PMID 16054063 DOI: 10.1016/J.Cmet.2005.02.002  0.669
2005 Kennedy MA, Barrera GC, Nakamura K, Baldán A, Tarr P, Fishbein MC, Frank J, Francone OL, Edwards PA. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metabolism. 1: 121-31. PMID 16054053 DOI: 10.1016/J.Cmet.2005.01.002  0.808
2005 Lee FY, Kast-Woelbern HR, Chang J, Luo G, Jones SA, Fishbein MC, Edwards PA. Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers. The Journal of Biological Chemistry. 280: 31792-800. PMID 16012168 DOI: 10.1074/Jbc.M503182200  0.66
2005 Anisfeld AM, Kast-Woelbern HR, Lee H, Zhang Y, Lee FY, Edwards PA. Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling. Journal of Lipid Research. 46: 458-68. PMID 15604525 DOI: 10.1194/Jlr.M400292-Jlr200  0.823
2004 Nakamura K, Kennedy MA, Baldán A, Bojanic DD, Lyons K, Edwards PA. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. The Journal of Biological Chemistry. 279: 45980-9. PMID 15319426 DOI: 10.1074/Jbc.M408652200  0.814
2004 Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA. Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes & Development. 18: 157-69. PMID 14729567 DOI: 10.1101/Gad.1138104  0.409
2003 Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Molecular Cell. 11: 1079-92. PMID 12718892 DOI: 10.1016/S1097-2765(03)00104-7  0.818
2003 Anisfeld AM, Kast-Woelbern HR, Meyer ME, Jones SA, Zhang Y, Williams KJ, Willson T, Edwards PA. Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor. The Journal of Biological Chemistry. 278: 20420-8. PMID 12660231 DOI: 10.1074/Jbc.M302505200  0.83
2003 Zhang Y, Kast-Woelbern HR, Edwards PA. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. The Journal of Biological Chemistry. 278: 104-10. PMID 12393883 DOI: 10.1074/Jbc.M209505200  0.539
2002 Mak PA, Kast-Woelbern HR, Anisfeld AM, Edwards PA. Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. Journal of Lipid Research. 43: 2037-41. PMID 12454263 DOI: 10.1194/Jlr.C200014-Jlr200  0.823
2002 Edwards PA, Kennedy MA, Mak PA. LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vascular Pharmacology. 38: 249-56. PMID 12449021 DOI: 10.1016/S1537-1891(02)00175-1  0.431
2002 Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. The Journal of Biological Chemistry. 277: 31900-8. PMID 12032151 DOI: 10.1074/Jbc.M202993200  0.761
2002 Edwards PA, Kast HR, Anisfeld AM. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. Journal of Lipid Research. 43: 2-12. PMID 11792716  0.801
2002 Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. The Journal of Biological Chemistry. 277: 2908-15. PMID 11706036 DOI: 10.1074/Jbc.M109326200  0.794
2001 Kast HR, Nguyen CM, Sinal CJ, Jones SA, Laffitte BA, Reue K, Gonzalez FJ, Willson TM, Edwards PA. Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. Molecular Endocrinology (Baltimore, Md.). 15: 1720-8. PMID 11579204 DOI: 10.1210/Mend.15.10.0712  0.82
2001 Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA. Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. The Journal of Biological Chemistry. 276: 39438-47. PMID 11500512 DOI: 10.1074/Jbc.M105863200  0.775
2001 Kast HR, Nguyen CM, Anisfeld AM, Ericsson J, Edwards PA. CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene. Journal of Lipid Research. 42: 1266-72. PMID 11483628  0.805
2001 Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Molecular Cell. 7: 161-71. PMID 11172721 DOI: 10.1016/S1097-2765(01)00164-2  0.751
2000 Edwards PA, Tabor D, Kast HR, Venkateswaran A. Regulation of gene expression by SREBP and SCAP. Biochimica Et Biophysica Acta. 1529: 103-13. PMID 11111080 DOI: 10.1016/S1388-1981(00)00140-2  0.817
2000 Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proceedings of the National Academy of Sciences of the United States of America. 97: 12097-102. PMID 11035776 DOI: 10.1073/Pnas.200367697  0.783
2000 Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. The Journal of Biological Chemistry. 275: 14700-7. PMID 10799558 DOI: 10.1074/Jbc.275.19.14700  0.522
2000 Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. The Journal of Biological Chemistry. 275: 10638-47. PMID 10744760 DOI: 10.1074/Jbc.275.14.10638  0.789
1999 Edwards PA, Ericsson J. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annual Review of Biochemistry. 68: 157-85. PMID 10872447 DOI: 10.1146/Annurev.Biochem.68.1.157  0.401
1999 Tabor DE, Kim JB, Spiegelman BM, Edwards PA. Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2. The Journal of Biological Chemistry. 274: 20603-10. PMID 10400691 DOI: 10.1074/Jbc.274.29.20603  0.448
1999 Ericsson J, Usheva A, Edwards PA. YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes. The Journal of Biological Chemistry. 274: 14508-13. PMID 10318878 DOI: 10.1074/jbc.274.20.14508  0.42
1998 Edwards PA, Ericsson J. Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease. Current Opinion in Lipidology. 9: 433-40. PMID 9812197 DOI: 10.1097/00041433-199810000-00007  0.407
1998 Tabor DE, Kim JB, Spiegelman BM, Edwards PA. Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1. The Journal of Biological Chemistry. 273: 22052-8. PMID 9705348 DOI: 10.1074/Jbc.273.34.22052  0.475
1998 Ericsson J, Edwards PA. CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription. The Journal of Biological Chemistry. 273: 17865-70. PMID 9651391 DOI: 10.1074/Jbc.273.28.17865  0.516
1997 Jackson SM, Ericsson J, Edwards PA. Signaling molecules derived from the cholesterol biosynthetic pathway. Sub-Cellular Biochemistry. 28: 1-21. PMID 9090289 DOI: 10.1007/978-1-4615-5901-6_1  0.329
1997 Ericsson J, Jackson SM, Kim JB, Spiegelman BM, Edwards PA. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. The Journal of Biological Chemistry. 272: 7298-305. PMID 9054427 DOI: 10.1074/Jbc.272.11.7298  0.454
1996 Ericsson J, Jackson SM, Edwards PA. Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene. The Journal of Biological Chemistry. 271: 24359-64. PMID 8798690 DOI: 10.1074/Jbc.271.40.24359  0.408
1996 Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arteriosclerosis, Thrombosis, and Vascular Biology. 16: 831-42. PMID 8673557 DOI: 10.1161/01.Atv.16.7.831  0.366
1996 Ericsson J, Jackson SM, Lee BC, Edwards PA. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Proceedings of the National Academy of Sciences of the United States of America. 93: 945-50. PMID 8570665 DOI: 10.1073/Pnas.93.2.945  0.441
1996 Edwards PA, Davis R. Chapter 13 Isoprenoids, sterols and bile acids New Comprehensive Biochemistry. 31: 341-362. DOI: 10.1016/S0167-7306(08)60520-7  0.304
1995 Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation. 91: 2488-96. PMID 7729036 DOI: 10.1161/01.Cir.91.9.2488  0.373
1995 Jackson SM, Ericsson J, Osborne TF, Edwards PA. NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes. The Journal of Biological Chemistry. 270: 21445-8. PMID 7665553 DOI: 10.1074/Jbc.270.37.21445  0.47
1995 Navab M, Fogelman AM, Berliner JA, Territo MC, Demer LL, Frank JS, Watson AD, Edwards PA, Lusis AJ. Pathogenesis of atherosclerosis. The American Journal of Cardiology. 76: 18C-23C. PMID 7572682 DOI: 10.1016/S0002-9149(99)80466-4  0.421
1992 Bork RW, Svenson KL, Mehrabian M, Lusis AJ, Fogelman AM, Edwards PA. Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology. 12: 800-6. PMID 1616905 DOI: 10.1161/01.Atv.12.7.800  0.422
1991 Teruya JH, Salido EC, Edwards PA, Clarke CF. Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells. Biology of Reproduction. 44: 663-71. PMID 2043737 DOI: 10.1095/Biolreprod44.4.663  0.588
1991 Edwards PA. Chapter 13 Regulation of sterol biosynthesis and isoprenylation of proteins New Comprehensive Biochemistry. 20: 383-401. DOI: 10.1016/S0167-7306(08)60341-5  0.461
1990 Teruya JH, Kutsunai SY, Spear DH, Edwards PA, Clarke CF. Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA. Molecular and Cellular Biology. 10: 2315-26. PMID 2325654 DOI: 10.1128/mcb.10.5.2315-2326.1990  0.623
1989 Heinzmann C, Clarke CF, Klisak I, Mohandas T, Sparkes RS, Edwards PA, Lusis AJ. Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase. Genomics. 5: 493-500. PMID 2613235 DOI: 10.1016/0888-7543(89)90015-3  0.567
1989 Levin MS, Pitt AJ, Schwartz AL, Edwards PA, Gordon JI. Developmental changes in the expression of genes involved in cholesterol biosynthesis and lipid transport in human and rat fetal and neonatal livers. Biochimica Et Biophysica Acta. 1003: 293-300. PMID 2472835 DOI: 10.1016/0005-2760(89)90235-X  0.416
1988 Fogelman AM, Van Lenten BJ, Warden C, Haberland ME, Edwards PA. Macrophage lipoprotein receptors. Journal of Cell Science. Supplement. 9: 135-49. PMID 2855802 DOI: 10.1242/Jcs.1988.Supplement_9.7  0.448
1987 Clarke CF, Tanaka RD, Svenson K, Wamsley M, Fogelman AM, Edwards PA. Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway. Molecular and Cellular Biology. 7: 3138-46. PMID 3670308 DOI: 10.1128/mcb.7.9.3138-3146.1987  0.603
1987 Clarke CF, Edwards PA, Fogelman AM. Chapter 8 Cellular regulation of cholesterol metabolism New Comprehensive Biochemistry. 14: 261-276. DOI: 10.1016/S0167-7306(08)60202-1  0.619
1986 Navab M, Hough GP, Berliner JA, Frank JA, Fogelman AM, Haberland ME, Edwards PA. Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance. The Journal of Clinical Investigation. 78: 389-97. PMID 3734098 DOI: 10.1172/Jci112589  0.374
1986 Van Lenten BJ, Fogelman AM, Haberland ME, Edwards PA. The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 83: 2704-8. PMID 3517876 DOI: 10.1073/Pnas.83.8.2704  0.35
1985 Clarke CF, Fogelman AM, Edwards PA. Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver. The Journal of Biological Chemistry. 260: 14363-7. PMID 3850901  0.577
1984 Clarke CF, Fogelman AM, Edwards PA. Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein. The Journal of Biological Chemistry. 259: 10439-47. PMID 6540773  0.536
1984 Baker DP, van Lenten BJ, Fogelman AM, Edwards PA, Kean C, Berliner JA. LDL, scavenger, and β-VLDL receptors on aortic endothelial cells Arteriosclerosis. 4: 248-255. PMID 6324733 DOI: 10.1161/01.Atv.4.3.248  0.37
1983 Clarke CF, Edwards PA, Lan SF, Tanaka RD, Fogelman AM. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver. Proceedings of the National Academy of Sciences of the United States of America. 80: 3305-8. PMID 6190175 DOI: 10.1073/Pnas.80.11.3305  0.578
1982 Haberland ME, Fogelman AM, Edwards PA. Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 79: 1712-6. PMID 6281781 DOI: 10.1073/Pnas.79.6.1712  0.423
1982 Fogelman AM, Seager J, Haberland ME, Hokom M, Tanaka R, Edwards PA. Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation. Proceedings of the National Academy of Sciences of the United States of America. 79: 922-6. PMID 6278500 DOI: 10.1073/Pnas.79.3.922  0.371
1980 Fogelman AM, Shechter I, Seager J, Hokom M, Child JS, Edwards PA. Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proceedings of the National Academy of Sciences of the United States of America. 77: 2214-8. PMID 6769124 DOI: 10.1073/Pnas.77.4.2214  0.37
1977 Fogelman AM, Seager J, Edwards PA, Hokom M, Popják G. Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. Biochemical and Biophysical Research Communications. 76: 167-73. PMID 869944 DOI: 10.1016/0006-291X(77)91682-5  0.323
1976 Edwards PA, Fogelman AM, Popják G. A direct relationship between the amount of sterol lost from rat hepatocytes and the increase in activity of HMG-CoA reductase. Biochemical and Biophysical Research Communications. 68: 64-9. PMID 1247463 DOI: 10.1016/0006-291X(76)90010-3  0.381
1974 Edwards PA, Gould RG. Dependence of the circadian rhythm of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A on ribonucleic acid synthesis. A possible second site of inhibition by dietary cholesterol. The Journal of Biological Chemistry. 249: 2891-6. PMID 4828326  0.578
1972 Edwards PA, Muroya H, Gould RG. In vivo demonstration of the circadian thythm of cholesterol biosynthesis in the liver and intestine of the rat. Journal of Lipid Research. 13: 396-401. PMID 5025468  0.617
1972 Edwards PA, Gould RG. Turnover rate of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by use of cycloheximide. The Journal of Biological Chemistry. 247: 1520-4. PMID 5012320  0.54
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