Leslie A. Leinwand - Publications

Affiliations: 
Molecular, Cellular and Developmental Biology University of Colorado, Boulder, Boulder, CO, United States 
Area:
Medical Biophysics, Physiology Biology, Biochemistry

223 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Magida JA, Tan Y, Wall CE, Harrison BC, Marr TG, Peter AK, Riquelme CA, Leinwand LA. Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage. The Journal of General Physiology. 154. PMID 35323838 DOI: 10.1085/jgp.202113008  0.756
2020 Ceccato TL, Starbuck RB, Hall JK, Walker CJ, Brown TE, Killgore JP, Anseth KS, Leinwand LA. Defining the Cardiac Fibroblast Secretome in a Fibrotic Microenvironment. Journal of the American Heart Association. e017025. PMID 32924724 DOI: 10.1161/Jaha.120.017025  0.328
2020 Karabina A, Liu C, Spudich JA, Leinwand LA. Functional Comparison of Homologous Mutations in Human Beta, Perinatal, and Embryonic Muscle Myosin Isoforms Biophysical Journal. 118: 433a. DOI: 10.1016/J.Bpj.2019.11.2432  0.305
2019 Iñigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, ... ... Leinwand LA, et al. Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Molecular Metabolism. 34: 1-15. PMID 32180550 DOI: 10.1016/J.Molmet.2019.12.010  0.31
2019 Liu Y, Afzal J, Vakrou S, Greenland GV, Talbot CC, Hebl VB, Guan Y, Karmali R, Tardiff JC, Leinwand LA, Olgin JE, Das S, Fukunaga R, Abraham MR. Differences in microRNA-29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy. Frontiers in Cardiovascular Medicine. 6: 170. PMID 31921893 DOI: 10.3389/Fcvm.2019.00170  0.316
2019 Bjorkman KK, Buvoli M, Pugach EK, Polmear MM, Leinwand LA. miR-1/206 downregulates splicing factor Srsf9 to promote C2C12 differentiation. Skeletal Muscle. 9: 31. PMID 31791406 DOI: 10.1186/S13395-019-0211-4  0.315
2019 Vera CD, Johnson CA, Walklate J, Adhikari A, Svicevic M, Mijailovich SM, Combs AC, Langer SJ, Ruppel KM, Spudich JA, Geeves MA, Leinwand LA. Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties. The Journal of Biological Chemistry. PMID 31582565 DOI: 10.1074/Jbc.Ra119.010563  0.324
2019 Johnson CA, Walklate J, Svicevic M, Mijailovich SM, Vera CD, Karabina A, Leinwand LA, Geeves MA. The ATPase cycle of human muscle myosin II Isoforms: adaptation of a single mechanochemical cycle for different physiological roles. The Journal of Biological Chemistry. PMID 31387944 DOI: 10.1074/Jbc.Ra119.009825  0.325
2019 Peter AK, Rossi AC, Buvoli M, Ozeroff CD, Crocini C, Perry AR, Buvoli AE, Lee LA, Leinwand LA. Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy. Journal of the American Heart Association. 8: e013318. PMID 31364453 DOI: 10.1161/Jaha.119.013318  0.418
2019 Lee LA, Karabina A, Broadwell LJ, Leinwand LA. The ancient sarcomeric myosins found in specialized muscles. Skeletal Muscle. 9: 7. PMID 30836986 DOI: 10.1186/S13395-019-0192-3  0.335
2019 Crocini C, Woulfe KC, Leinwand LA. Novel Morphological and Functional Insights in Python Cardiac Biology Biophysical Journal. 116: 154a. DOI: 10.1016/J.Bpj.2018.11.855  0.316
2018 Ujfalusi Z, Vera CD, Mijailovich SM, Svicevic M, Yu EC, Kawana M, Ruppel K, Spudich JA, Geeves MA, Leinwand LA. Dilated cardiomyopathy myosin mutants have reduced force-generating capacity. The Journal of Biological Chemistry. PMID 29666183 DOI: 10.1074/Jbc.Ra118.001938  0.323
2018 Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O'Rourke B, Aon MA, et al. Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models. Jci Insight. 3. PMID 29563334 DOI: 10.1172/Jci.Insight.94493  0.312
2018 Peter AK, Christensen TL, Walker CJ, Trexler CL, Ozeroff CD, Lugo KR, Perry AR, Anseth KS, Leinwand LA. Abstract 266: Sex Differences in Survival and Pathological Responses of Hearts, Cardiac Myocytes and Fibroblasts Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.266  0.321
2018 Christensen T, Anseth K, Leinwand L. Matrix Stiffness Contributes to Pathological Activation of Cardiac Fibroblasts Biophysical Journal. 114: 110a. DOI: 10.1016/J.Bpj.2017.11.635  0.302
2017 Luckey SW, Haines CD, Konhilas JP, Luczak ED, Messmer-Kratzsch A, Leinwand LA. Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy. Experimental Biology and Medicine (Maywood, N.J.). 1535370217731503. PMID 28901173 DOI: 10.1177/1535370217731503  0.695
2017 Vega RB, Konhilas JP, Kelly DP, Leinwand LA. Molecular Mechanisms Underlying Cardiac Adaptation to Exercise. Cell Metabolism. 25: 1012-1026. PMID 28467921 DOI: 10.1016/J.Cmet.2017.04.025  0.307
2017 Wan W, Leinwand L. Computational Approach to Measuring Myocyte Disarray in Animal Models of Heart Disease. Current Protocols in Human Genetics. 93: 15.11.1-15.11.9. PMID 28384401 DOI: 10.1002/Cphg.35  0.311
2017 Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy C, Garza NG, Hay W, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. The Journal of Endocrinology. PMID 28053000 DOI: 10.1530/Joe-16-0123  0.315
2017 Christensen T, Anseth K, Leinwand L. Understanding the Role of Stiffness in Pathological Cardiac Fibroblast Signaling Biophysical Journal. 112: 433a. DOI: 10.1016/J.Bpj.2016.11.2312  0.345
2016 Feinstein-Linial M, Buvoli M, Buvoli A, Sadeh M, Dabby R, Straussberg R, Shelef I, Dayan D, Leinwand LA, Birk OS. Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture. Bmc Medical Genetics. 17: 57-57. PMID 27519903 DOI: 10.1186/S12881-016-0315-1  0.359
2016 Peter AK, Bjerke MA, Leinwand LA. Biology of the cardiac myocyte in heart disease. Molecular Biology of the Cell. 27: 2149-60. PMID 27418636 DOI: 10.1091/Mbc.E16-01-0038  0.778
2016 Pugach EK, Blenck CL, Dragavon JM, Langer SJ, Leinwand LA. Estrogen receptor profiling and activity in cardiac myocytes. Molecular and Cellular Endocrinology. PMID 27164442 DOI: 10.1016/J.Mce.2016.05.004  0.356
2016 Walklate J, Vera C, Bloemink MJ, Geeves MA, Leinwand L. The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects. The Journal of Biological Chemistry. 291: 10318-31. PMID 26945064 DOI: 10.1074/Jbc.M115.707489  0.348
2016 Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science (New York, N.Y.). 351: 617-21. PMID 26912705 DOI: 10.1126/Science.Aad3456  0.409
2016 Vera Velazquez CD, Walklate J, Geeves MA, Leinwand LA. β-MYHC Mutations Linked to Early-Onset HCM and DCM Show Differences in Pre-Steady and Steady State Kinetic Parameters Biophysical Journal. 110: 614a. DOI: 10.1016/J.Bpj.2015.11.3295  0.331
2016 Adhikari AS, Bezold Kooiker K, Sutton S, Bernstein D, Leinwand LA, Ruppel KM, Spudich JA. The Effect of Pediatric Specific Hypertrophic Cardiomyopathy Mutations on the Biomechanics of Beta Cardiac Myosin Biophysical Journal. 110: 295a. DOI: 10.1016/J.Bpj.2015.11.1592  0.326
2015 Nag S, Sommese RF, Ujfalusi Z, Combs A, Langer S, Sutton S, Leinwand LA, Geeves MA, Ruppel KM, Spudich JA. Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function. Science Advances. 1: e1500511. PMID 26601291 DOI: 10.1126/Sciadv.1500511  0.359
2015 Schiaffino S, Rossi AC, Smerdu V, Leinwand LA, Reggiani C. Developmental myosins: expression patterns and functional significance. Skeletal Muscle. 5: 22. PMID 26180627 DOI: 10.1186/S13395-015-0046-6  0.344
2015 Pugach EK, Richmond PA, Azofeifa JG, Dowell RD, Leinwand LA. Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic. Journal of Molecular and Cellular Cardiology. 86: 54-61. PMID 26141530 DOI: 10.1016/J.Yjmcc.2015.06.019  0.396
2015 Hajj GP, Chu Y, Lund DD, Magida JA, Funk ND, Brooks RM, Baumbach GL, Zimmerman KA, Davis MK, El Accaoui RN, Hameed T, Doshi H, Chen B, Leinwand LA, Song LS, et al. Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 1653-62. PMID 25997932 DOI: 10.1161/Atvbaha.115.305729  0.763
2015 Haizlip KM, Harrison BC, Leinwand LA. Sex-based differences in skeletal muscle kinetics and fiber-type composition. Physiology (Bethesda, Md.). 30: 30-9. PMID 25559153 DOI: 10.1152/Physiol.00024.2014  0.313
2015 Konhilas JP, Chen H, Luczak E, McKee LA, Regan J, Watson PA, Stauffer BL, Khalpey ZI, Mckinsey TA, Horn T, LaFleur B, Leinwand LA. Diet and sex modify exercise and cardiac adaptation in the mouse. American Journal of Physiology. Heart and Circulatory Physiology. 308: H135-45. PMID 25398983 DOI: 10.1152/Ajpheart.00532.2014  0.689
2015 Velazquez CV, Walklate J, Deacon J, Geeves MA, Leinwand LA. Functional Analysis of Freeman-Sheldon Syndrome Causing Mutations on Embryonic Myosin Biophysical Journal. 108: 304a. DOI: 10.1016/J.Bpj.2014.11.1652  0.302
2014 Wang H, Leinwand LA, Anseth KS. Cardiac valve cells and their microenvironment--insights from in vitro studies. Nature Reviews. Cardiology. 11: 715-27. PMID 25311230 DOI: 10.1038/Nrcardio.2014.162  0.319
2014 Wang H, Leinwand LA, Anseth KS. Roles of transforming growth factor-β1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4551-62. PMID 25008089 DOI: 10.1096/Fj.14-254623  0.312
2014 Magida JA, Leinwand LA. Metabolic crosstalk between the heart and liver impacts familial hypertrophic cardiomyopathy. Embo Molecular Medicine. 6: 482-95. PMID 24567073 DOI: 10.1002/Emmm.201302852  0.791
2014 Chung E, Leinwand LA. Pregnancy as a cardiac stress model. Cardiovascular Research. 101: 561-70. PMID 24448313 DOI: 10.1093/Cvr/Cvu013  0.303
2014 Bloemink M, Deacon J, Langer S, Vera C, Combs A, Leinwand L, Geeves MA. The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin. The Journal of Biological Chemistry. 289: 5158-67. PMID 24344137 DOI: 10.1074/Jbc.M113.511204  0.772
2014 Lee W, Park Y, Leinwand LA, Chung E. The Akt/FoxO3a/Atrogin-1 Signaling Pathways Underlying Cardiac Regression after Detraining in a Mouse Heart.: 1305 Board #45 May 29, 9 Medicine and Science in Sports and Exercise. 46: 338. DOI: 10.1249/01.Mss.0000494194.09895.3E  0.321
2014 Bloemink M, Deacon J, Langer S, Vera C, Combs A, Leinwand L, Geeves MA. The Hcm Mutation R453C in the Human Beta Myosin Motor Domain Alters the ATP-Binding and Hydrolysis Steps Biophysical Journal. 106: 561a. DOI: 10.1016/J.Bpj.2013.11.3119  0.318
2013 Kucherlapati R, Leinwand LA. Frank Ruddle (1929-2013). American Journal of Human Genetics. 92: 839-40. PMID 24242788 DOI: 10.1016/J.Ajhg.2013.05.012  0.488
2013 Wang H, Sridhar B, Leinwand LA, Anseth KS. Characterization of cell subpopulations expressing progenitor cell markers in porcine cardiac valves. Plos One. 8: e69667. PMID 23936071 DOI: 10.1371/Journal.Pone.0069667  0.319
2013 Guess MG, Barthel KK, Pugach EK, Leinwand LA. Measuring microRNA reporter activity in skeletal muscle using hydrodynamic limb vein injection of plasmid DNA combined with in vivo imaging. Skeletal Muscle. 3: 19. PMID 23915674 DOI: 10.1186/2044-5040-3-19  0.327
2013 Bloemink MJ, Deacon JC, Resnicow DI, Leinwand LA, Geeves MA. The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms. The Journal of Biological Chemistry. 288: 27469-79. PMID 23908353 DOI: 10.1074/Jbc.M113.488130  0.788
2013 Sommese RF, Sung J, Nag S, Sutton S, Deacon JC, Choe E, Leinwand LA, Ruppel K, Spudich JA. Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function. Proceedings of the National Academy of Sciences of the United States of America. 110: 12607-12. PMID 23798412 DOI: 10.1073/Pnas.1309493110  0.791
2013 Leinwand LA, Harrison BC. Young at heart. Cell. 153: 743-5. PMID 23663775 DOI: 10.1016/J.Cell.2013.04.038  0.316
2013 Xu R, Andres-Mateos E, Mejias R, MacDonald EM, Leinwand LA, Merriman DK, Fink RH, Cohn RD. Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization. Experimental Neurology. 247: 392-401. PMID 23333568 DOI: 10.1016/J.Expneurol.2013.01.005  0.32
2013 Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Files DC, Steinberger M, Soleimani A, Marx R, Simmers JL, Lin B, Finanger Hedderick E, Marr TG, Lin BM, Hourdé C, Leinwand LA, et al. Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. Embo Molecular Medicine. 5: 80-91. PMID 23161797 DOI: 10.1002/Emmm.201201443  0.305
2012 Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, ... Leinwand LA, et al. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 151: 1319-31. PMID 23217713 DOI: 10.1016/J.Cell.2012.10.050  0.334
2012 Andres-Mateos E, Mejias R, Soleimani A, Lin BM, Burks TN, Marx R, Lin B, Zellars RC, Zhang Y, Huso DL, Marr TG, Leinwand LA, Merriman DK, Cohn RD. Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels. Plos One. 7: e48884. PMID 23155423 DOI: 10.1371/Journal.Pone.0048884  0.307
2012 Cosper PF, Harvey PA, Leinwand LA. Interferon-γ causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis. The American Journal of Pathology. 181: 2038-46. PMID 23058369 DOI: 10.1016/J.Ajpath.2012.08.040  0.741
2012 Deacon JC, Bloemink MJ, Rezavandi H, Geeves MA, Leinwand LA. Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors. Cellular and Molecular Life Sciences : Cmls. 69: 4239-55. PMID 23001010 DOI: 10.1007/S00018-012-1111-5  0.773
2012 Moore JR, Leinwand L, Warshaw DM. Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor. Circulation Research. 111: 375-85. PMID 22821910 DOI: 10.1161/Circresaha.110.223842  0.325
2012 Wang H, Haeger SM, Kloxin AM, Leinwand LA, Anseth KS. Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus. Plos One. 7: e39969. PMID 22808079 DOI: 10.1371/Journal.Pone.0039969  0.322
2012 Haines CD, Harvey PA, Luczak ED, Barthel KK, Konhilas JP, Watson PA, Stauffer BL, Leinwand LA. Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease. Endocrinology. 153: 4470-9. PMID 22778230 DOI: 10.1210/En.2012-1391  0.689
2012 Leinwand LA, Tardiff JC, Gregorio CC. Mutations in the sensitive giant titin result in a broken heart. Circulation Research. 111: 158-61. PMID 22773424 DOI: 10.1161/Res.0B013E3182635Ca2  0.343
2012 Haines CD, Harvey PA, Leinwand LA. Estrogens mediate cardiac hypertrophy in a stimulus-dependent manner. Endocrinology. 153: 4480-90. PMID 22759381 DOI: 10.1210/En.2012-1353  0.342
2012 Yeung F, Chung E, Guess MG, Bell ML, Leinwand LA. Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos. Nucleic Acids Research. 40: 7303-18. PMID 22638570 DOI: 10.1093/Nar/Gks466  0.325
2012 Spangenburg EE, Geiger PC, Leinwand LA, Lowe DA. Regulation of physiological and metabolic function of muscle by female sex steroids. Medicine and Science in Sports and Exercise. 44: 1653-62. PMID 22525764 DOI: 10.1249/Mss.0B013E31825871Fa  0.301
2012 Deacon JC, Bloemink MJ, Rezavandi H, Geeves MA, Leinwand LA. Identification of functional differences between recombinant human α and β cardiac myosin motors. Cellular and Molecular Life Sciences : Cmls. 69: 2261-77. PMID 22349210 DOI: 10.1007/S00018-012-0927-3  0.773
2012 Chung E, Yeung F, Leinwand LA. Akt and MAPK signaling mediate pregnancy-induced cardiac adaptation. Journal of Applied Physiology (Bethesda, Md. : 1985). 112: 1564-75. PMID 22345431 DOI: 10.1152/Japplphysiol.00027.2012  0.339
2012 Buvoli M, Buvoli A, Leinwand LA. Effects of pathogenic proline mutations on myosin assembly. Journal of Molecular Biology. 415: 807-18. PMID 22155079 DOI: 10.1016/J.Jmb.2011.11.042  0.314
2012 Cosper PF, Leinwand LA. Myosin heavy chain is not selectively decreased in murine cancer cachexia. International Journal of Cancer. 130: 2722-7. PMID 21796617 DOI: 10.1002/Ijc.26298  0.721
2012 Sung J, Choe E, Elting M, Nag S, Sutton S, Deacon J, Leinwand L, Ruppel K, Spudich J. Single Molecule Studies of Recombinant Human α- and β-Cardiac Myosin to Elucidate Molecular Mechanism of Familial Hypertrophic and Dilated Cardiomyopathies Biophysical Journal. 102: 613a-614a. DOI: 10.1016/J.Bpj.2011.11.3345  0.79
2012 McKee L, Regan J, Chen H, Walker J, Leinwand LA, Konhilas JP. Target Specific Phosphorylation of Cardiac Troponin I and Sex Dimorphic Myofilament Function in R403Q Mice Biophysical Journal. 102: 555a-556a. DOI: 10.1016/J.Bpj.2011.11.3027  0.364
2012 Solaro RJ, Leinwand LA. Role of sarcomeres in cellular tension, shortening, and signaling in cardiac muscle Muscle. 1: 161-172. DOI: 10.1016/B978-0-12-381510-1.00013-2  0.363
2011 Riquelme CA, Magida JA, Harrison BC, Wall CE, Marr TG, Secor SM, Leinwand LA. Fatty acids identified in the Burmese python promote beneficial cardiac growth. Science (New York, N.Y.). 334: 528-31. PMID 22034436 DOI: 10.1126/Science.1210558  0.781
2011 Harvey PA, Leinwand LA. The cell biology of disease: cellular mechanisms of cardiomyopathy. The Journal of Cell Biology. 194: 355-65. PMID 21825071 DOI: 10.1083/Jcb.201101100  0.366
2011 Harrison BC, Allen DL, Leinwand LA. IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men. Skeletal Muscle. 1: 5. PMID 21798083 DOI: 10.1186/2044-5040-1-5  0.361
2011 Lemon DD, Horn TR, Cavasin MA, Jeong MY, Haubold KW, Long CS, Irwin DC, McCune SA, Chung E, Leinwand LA, McKinsey TA. Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. Journal of Molecular and Cellular Cardiology. 51: 41-50. PMID 21539845 DOI: 10.1016/J.Yjmcc.2011.04.005  0.78
2011 Luczak ED, Barthel KK, Stauffer BL, Konhilas JP, Cheung TH, Leinwand LA. Remodeling the cardiac transcriptional landscape with diet. Physiological Genomics. 43: 772-80. PMID 21487031 DOI: 10.1152/Physiolgenomics.00237.2010  0.706
2011 Leinwand LA, Moss RL. Medicine. Chemically tuned myosin motors. Science (New York, N.Y.). 331: 1392-3. PMID 21415340 DOI: 10.1126/Science.1204207  0.343
2011 Cosper PF, Leinwand LA. Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner. Cancer Research. 71: 1710-20. PMID 21163868 DOI: 10.1158/0008-5472.Can-10-3145  0.741
2011 Wall CE, Cozza S, Riquelme CA, McCombie WR, Heimiller JK, Marr TG, Leinwand LA. Whole transcriptome analysis of the fasting and fed Burmese python heart: Insights into extreme physiological cardiac adaptation Physiological Genomics. 43: 69-76. PMID 21045117 DOI: 10.1152/Physiolgenomics.00162.2010  0.375
2011 Deacon JC, Bloemink MJ, Geeves MA, Leinwand LA. Kinetic Analysis of Human α and β Cardiac Myosin Motor Domains Biophysical Journal. 100: 369a-370a. DOI: 10.1016/J.Bpj.2010.12.2204  0.764
2010 Konhilas JP, Boucek DM, Horn TR, Johnson GL, Leinwand LA. The role of MEKK1 in hypertrophic cardiomyopathy. International Heart Journal. 51: 277-84. PMID 20716846 DOI: 10.1536/Ihj.51.277  0.347
2010 Resnicow DI, Deacon JC, Warrick HM, Spudich JA, Leinwand LA. Functional diversity among a family of human skeletal muscle myosin motors. Proceedings of the National Academy of Sciences of the United States of America. 107: 1053-8. PMID 20080549 DOI: 10.1073/Pnas.0913527107  0.785
2010 Armel TZ, Leinwand LA. A mutation in the beta-myosin rod associated with hypertrophic cardiomyopathy has an unexpected molecular phenotype. Biochemical and Biophysical Research Communications. 391: 352-6. PMID 19913502 DOI: 10.1016/J.Bbrc.2009.11.062  0.301
2010 Armel TZ, Leinwand LA. Mutations at the same amino acid in myosin that cause either skeletal or cardiac myopathy have distinct molecular phenotypes. Journal of Molecular and Cellular Cardiology. 48: 1007-13. PMID 19854198 DOI: 10.1016/J.Yjmcc.2009.10.011  0.317
2010 Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, ... ... Leinwand LA, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95. PMID 19679181 DOI: 10.1016/J.Bbi.2009.08.004  0.584
2010 Resnicow DI, Deacon JC, Warrick HM, Spudich JA, Leinwand LA. Functional diversity among a family of human skeletal muscle myosin motors (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 3 (1053-1058) DOI: 10.1073/pnas.0913527107) Proceedings of the National Academy of Sciences of the United States of America. 107: 10765. DOI: 10.1073/pnas.1005980107  0.752
2010 Sivaramakrishnan S, Ashley E, Leinwand L, Spudich JA. Erratum: Insights into Human β-Cardiac Myosin Function from Single Molecule and Single Cell Studies Journal of Cardiovascular Translational Research. 4: 114-114. DOI: 10.1007/S12265-010-9251-1  0.313
2009 Sivaramakrishnan S, Ashley E, Leinwand L, Spudich JA. Insights into human beta-cardiac myosin function from single molecule and single cell studies. Journal of Cardiovascular Translational Research. 2: 426-40. PMID 20560001 DOI: 10.1007/S12265-009-9129-2  0.332
2009 Sloane E, Langer S, Jekich B, Mahoney J, Hughes T, Frank M, Seibert W, Huberty G, Coats B, Harrison J, Klinman D, Poole S, Maier S, Johnson K, Chavez R, ... ... Leinwand L, et al. Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain. Gene Therapy. 16: 1210-22. PMID 19571887 DOI: 10.1038/Gt.2009.79  0.617
2009 Hughes TS, Langer SJ, Virtanen SI, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression. The Journal of Gene Medicine. 11: 782-90. PMID 19533588 DOI: 10.1002/Jgm.1364  0.631
2009 Armel TZ, Leinwand LA. Mutations in the beta-myosin rod cause myosin storage myopathy via multiple mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 106: 6291-6. PMID 19336582 DOI: 10.1073/Pnas.0900107106  0.319
2009 Luckey SW, Walker LA, Smyth T, Mansoori J, Messmer-Kratzsch A, Rosenzweig A, Olson EN, Leinwand LA. The role of Akt/GSK-3β signaling in familial hypertrophic cardiomyopathy Journal of Molecular and Cellular Cardiology. 46: 739-747. PMID 19233194 DOI: 10.1016/J.Yjmcc.2009.02.010  0.375
2009 Hughes TS, Langer SJ, Johnson KW, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 88-94. PMID 18941439 DOI: 10.1038/Mt.2008.230  0.623
2009 Luczak ED, Leinwand LA. Sex-based cardiac physiology. Annual Review of Physiology. 71: 1-18. PMID 18828746 DOI: 10.1146/Annurev.Physiol.010908.163156  0.702
2008 Chung E, Leinwand LA. Rescuing cardiac malfunction: the roles of the chaperone-like small heat shock proteins. Circulation Research. 103: 1351-3. PMID 19059837 DOI: 10.1161/Circresaha.108.189720  0.346
2008 Jensen DR, Knaub LA, Konhilas JP, Leinwand LA, MacLean PS, Eckel RH. Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: An avian phenotype? Journal of Lipid Research. 49: 870-879. PMID 18175800 DOI: 10.1194/Jlr.M700519-Jlr200  0.323
2007 Sheren J, Langer SJ, Leinwand LA. A randomized library approach to identifying functional lox site domains for the Cre recombinase. Nucleic Acids Research. 35: 5464-73. PMID 17702764 DOI: 10.1093/Nar/Gkm604  0.762
2007 Watson PA, Reusch JE, McCune SA, Leinwand LA, Luckey SW, Konhilas JP, Brown DA, Chicco AJ, Sparagna GC, Long CS, Moore RL. Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise. American Journal of Physiology. Heart and Circulatory Physiology. 293: H246-59. PMID 17337597 DOI: 10.1152/Ajpheart.00734.2006  0.363
2007 Luckey SW, Mansoori J, Fair K, Antos CL, Olson EN, Leinwand LA. Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males. American Journal of Physiology. Heart and Circulatory Physiology. 292: H838-45. PMID 17012357 DOI: 10.1152/Ajpheart.00615.2006  0.315
2006 Milligan ED, Soderquist RG, Malone SM, Mahoney JH, Hughes TS, Langer SJ, Sloane EM, Maier SF, Leinwand LA, Watkins LR, Mahoney MJ. Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain. Neuron Glia Biology. 2: 293-308. PMID 18079973 DOI: 10.1017/S1740925X07000488  0.617
2006 Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, et al. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain. 126: 294-308. PMID 16949747 DOI: 10.1016/J.Pain.2006.07.009  0.616
2006 Dennehey BK, Leinwand LA, Krauter KS. Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts. Journal of Muscle Research and Cell Motility. 27: 559-75. PMID 16819597 DOI: 10.1007/S10974-006-9071-8  0.362
2006 Konhilas JP, Leinwand LA. Partnering up for cardiac hypertrophy. Circulation Research. 98: 985-7. PMID 16645146 DOI: 10.1161/01.Res.0000221823.31424.47  0.388
2006 Beylkin DH, Allen DL, Leinwand LA. MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes. Developmental Biology. 294: 541-53. PMID 16584724 DOI: 10.1016/J.Ydbio.2006.02.049  0.752
2006 Stauffer BL, Konhilas JP, Luczak ED, Leinwand LA. Soy diet worsens heart disease in mice. The Journal of Clinical Investigation. 116: 209-16. PMID 16395406 DOI: 10.1172/Jci24676  0.7
2006 Langer SJ, Busha D, Milligan ED, Hughes TS, Wieseler-Frank J, Watkins LR, Leinwand LA. 261. In Vivo Over-Expression of Fractalkine, a Putative Neuron-to-Glia Signal, To Characterize Underlying Mechanisms of Neuropathic Pain Molecular Therapy. 13: S100. DOI: 10.1016/J.Ymthe.2006.08.288  0.728
2006 Hughes T, Langer S, Sloane E, Mahoney J, Jekich B, Johnson K, Chavez R, Milligan E, Watkins L, Leinwand L. 260. ITRs Necessary for IL-10 Encoding Naked Plasmid Induced Reversal of Chronic Pain State in Rat Molecular Therapy. 13: S100. DOI: 10.1016/J.Ymthe.2006.08.287  0.628
2006 Milligan ED, Langer SJ, Hughes TS, Sloane EM, Mahoney JH, Jekich BM, Maier SF, Leinwand LA, Watkins LR. 259. Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) for Chronic Pain Control: Taking Advantage of Nuclear Scaffold/Matrix Attachment Regions Molecular Therapy. 13: S99. DOI: 10.1016/J.Ymthe.2006.08.286  0.619
2005 Konhilas JP, Widegren U, Allen DL, Paul AC, Cleary A, Leinwand LA. Loaded wheel running and muscle adaptation in the mouse. American Journal of Physiology. Heart and Circulatory Physiology. 289: H455-65. PMID 15734890 DOI: 10.1152/Ajpheart.00085.2005  0.342
2005 Allen DL, Weber JN, Sycuro LK, Leinwand LA. Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. The Journal of Biological Chemistry. 280: 17126-34. PMID 15728583 DOI: 10.1074/Jbc.M501207200  0.587
2005 Mariner PD, Luckey SW, Long CS, Sucharov CC, Leinwand LA. Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy. Biochemical and Biophysical Research Communications. 326: 79-86. PMID 15567155 DOI: 10.1016/J.Bbrc.2004.11.008  0.327
2005 Sheren JE, Ketner E, Keith J, Langer SJ, Leinwand LA. 1099. Beyond LoxP: Defining Functional Lox-Like Sequences for the Cre Recombinase Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.647  0.76
2005 Milligan ED, Mahoney MJ, Langer SJ, Hughes T, Sloane EM, Mahoney J, Jekich B, Cruz PE, Flotte TR, Maier SF, Johnson KW, Leinwand LA, Chavez RA, Watkins LR. 644. Gene Delivery for Chronic Pain Control: Micrcroencapsulated Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.184  0.618
2004 Maass AH, Ikeda K, Oberdorf-Maass S, Maier SK, Leinwand LA. Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T. Circulation. 110: 2102-9. PMID 15466629 DOI: 10.1161/01.Cir.0000144460.84795.E3  0.37
2004 Masters KS, Shah DN, Walker G, Leinwand LA, Anseth KS. Designing scaffolds for valvular interstitial cells: cell adhesion and function on naturally derived materials. Journal of Biomedical Materials Research. Part A. 71: 172-80. PMID 15368267 DOI: 10.1002/Jbm.A.30149  0.583
2004 Sucharov CC, Helmke SM, Langer SJ, Perryman MB, Bristow M, Leinwand L. The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression. Molecular and Cellular Biology. 24: 8705-15. PMID 15367688 DOI: 10.1128/Mcb.24.19.8705-8715.2004  0.372
2004 Walker GA, Masters KS, Shah DN, Anseth KS, Leinwand LA. Valvular myofibroblast activation by transforming growth factor-beta: implications for pathological extracellular matrix remodeling in heart valve disease. Circulation Research. 95: 253-60. PMID 15217906 DOI: 10.1161/01.Res.0000136520.07995.Aa  0.564
2004 Stelzer JE, Patel JR, Olsson MC, Fitzsimons DP, Leinwand LA, Moss RL. Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 287: H1756-61. PMID 15165990 DOI: 10.1152/Ajpheart.00172.2004  0.319
2004 Olsson MC, Palmer BM, Stauffer BL, Leinwand LA, Moore RL. Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy. Circulation Research. 94: 201-7. PMID 14670849 DOI: 10.1161/01.Res.0000111521.40760.18  0.383
2004 Stauffer BL, Leinwand LA. Sex differences in cardiac muscle and remodeling Advances in Molecular and Cell Biology. 34: 131-145. DOI: 10.1016/S1569-2558(03)34010-X  0.33
2004 Sucharov CC, Helmke S, Langer S, Perryman B, Bristow MR, Leinwand LA. The ku protein complex interacts with YY1, is up-regulated in human heart failure and represses alpha myosin heavy chain gene expression and promoter activity Journal of Cardiac Failure. 10. DOI: 10.1016/J.Cardfail.2004.06.001  0.316
2003 Rice NA, Leinwand LA. Skeletal myosin heavy chain function in cultured lung myofibroblasts. The Journal of Cell Biology. 163: 119-29. PMID 14557251 DOI: 10.1083/Jcb.200303194  0.364
2003 Leinwand LA. Hope for a broken heart? Cell. 114: 658-9. PMID 14505565 DOI: 10.1016/S0092-8674(03)00718-9  0.309
2003 Maass AH, Leinwand LA. Mechanisms of the pathogenesis of troponin T-based familial hypertrophic cardiomyopathy. Trends in Cardiovascular Medicine. 13: 232-7. PMID 12922019 DOI: 10.1016/S1050-1738(03)00100-2  0.366
2003 Leinwand LA. Sex is a potent modifier of the cardiovascular system. The Journal of Clinical Investigation. 112: 302-7. PMID 12897194 DOI: 10.1172/Jci19429  0.309
2003 Harrison BC, Allen DL, Girten B, Stodieck LS, Kostenuik PJ, Bateman TA, Morony S, Lacey D, Leinwand LA. Skeletal muscle adaptations to microgravity exposure in the mouse. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 2462-70. PMID 12882990 DOI: 10.1152/Japplphysiol.00603.2003  0.315
2003 Haubold KW, Allen DL, Capetanaki Y, Leinwand LA. Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 1617-22. PMID 12844497 DOI: 10.1152/Japplphysiol.00408.2003  0.764
2003 Maass A, Langer SJ, Oberdorf-Maass S, Bauer S, Neyses L, Leinwand LA. Rational promoter selection for gene transfer into cardiac cells. Journal of Molecular and Cellular Cardiology. 35: 823-31. PMID 12818573 DOI: 10.1016/S0022-2828(03)00140-8  0.369
2003 Carnes J, Jacobson M, Leinwand L, Yarus M. Stop codon suppression via inhibition of eRF1 expression. Rna (New York, N.Y.). 9: 648-53. PMID 12756323 DOI: 10.1261/Rna.5280103  0.697
2003 Sucharov CC, Mariner P, Long C, Bristow M, Leinwand L. Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter. The Journal of Biological Chemistry. 278: 31233-9. PMID 12754214 DOI: 10.1074/Jbc.M301917200  0.374
2003 Weisbart RH, Yang F, Chan G, Wakelin R, Ferreri K, Zack DJ, Harrison B, Leinwand LA, Cole GM. Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb. Molecular Immunology. 39: 783-9. PMID 12617993 DOI: 10.1016/S0161-5890(03)00003-8  0.309
2003 Buvoli M, Buvoli A, Leinwand LA. Suppressor tRNAs: protocols and applications for cardiac gene transfer. Methods in Molecular Biology (Clifton, N.J.). 219: 115-27. PMID 12597002 DOI: 10.1385/1-59259-350-X:115  0.301
2003 Haubold K, Herrmann H, Langer SJ, Evans RM, Leinwand LA, Klymkowsky MW. Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes. Cell Motility and the Cytoskeleton. 54: 105-21. PMID 12529857 DOI: 10.1002/Cm.10090  0.784
2003 Lucas DT, Aryal P, Szweda LI, Koch WJ, Leinwand LA. Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology. 284: H575-83. PMID 12414446 DOI: 10.1152/Ajpheart.00619.2002  0.349
2002 Maass A, Konhilas JP, Stauffer BL, Leinwand LA. From sarcomeric mutations to heart disease: Understanding familial hypertrophic cardiomyopathy Cold Spring Harbor Symposia On Quantitative Biology. 67: 409-415. PMID 12858566 DOI: 10.1101/Sqb.2002.67.409  0.3
2002 Petersen HH, Choy J, Stauffer B, Moien-Afshari F, Aalkjaer C, Leinwand L, McManus BM, Laher I. Coronary artery myogenic response in a genetic model of hypertrophic cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology. 283: H2244-9. PMID 12388227 DOI: 10.1152/Ajpheart.00606.2002  0.316
2002 Allen DL, Leinwand LA. Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter. The Journal of Biological Chemistry. 277: 45323-30. PMID 12235157 DOI: 10.1074/Jbc.M208302200  0.3
2002 Buvoli M, Leinwand LA. Direct gene transfer into mouse heart. Methods in Enzymology. 346: 134-42. PMID 11883064 DOI: 10.1016/S0076-6879(02)46053-3  0.309
2002 Buvoli M, Langer SJ, Bialik S, Leinwand LA. Potential limitations of transcription terminators used as transgene insulators in adenoviral vectors Gene Therapy. 9: 227-231. PMID 11859427 DOI: 10.1038/Sj.Gt.3301640  0.374
2002 Harrison BC, Bell ML, Allen DL, Byrnes WC, Leinwand LA. Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 92: 313-22. PMID 11744674 DOI: 10.1152/Japplphysiol.00832.2001  0.33
2001 Allen DL, Sartorius CA, Sycuro LK, Leinwand LA. Different pathways regulate expression of the skeletal myosin heavy chain genes. The Journal of Biological Chemistry. 276: 43524-33. PMID 11551968 DOI: 10.1074/Jbc.M108017200  0.362
2001 Freeman K, Nakao K, Leinwand LA. Low sequence variation in the gene encoding the human β-myosin heavy chain Genomics. 76: 73-80. PMID 11549319 DOI: 10.1006/Geno.2001.6573  0.321
2001 Maass A, Leinwand LA. A role for calreticulin in the adult heart? Journal of Clinical Investigation. 107: 1223-1225. PMID 11375411 DOI: 10.1172/Jci13125  0.381
2001 Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, Leinwand LA. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. The Journal of Clinical Investigation. 107: 967-74. PMID 11306600 DOI: 10.1172/Jci12083  0.369
2001 Allen DL, Harrison BC, Maass A, Bell ML, Byrnes WC, Leinwand LA. Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse. Journal of Applied Physiology (Bethesda, Md. : 1985). 90: 1900-8. PMID 11299284 DOI: 10.1152/Jappl.2001.90.5.1900  0.333
2001 Sébillon P, Bonne G, Flavigny J, Venin S, Rouche A, Fiszman M, Vikstrom K, Leinwand L, Carrier L, Schwartz K. COOH-terminal truncated human cardiac MyBP-C alters myosin filament organization. Comptes Rendus De L Academie Des Sciences Serie Iii-Sciences De La Vie-Life Sciences. 324: 251-260. PMID 11291312 DOI: 10.1016/S0764-4469(00)01292-0  0.342
2001 Leinwand LA. Calcineurin inhibition and cardiac hypertrophy: A matter of balance Proceedings of the National Academy of Sciences of the United States of America. 98: 2947-2949. PMID 11248009 DOI: 10.1073/Pnas.051033698  0.355
2001 Walker GA, Guerrero IA, Leinwand LA. Myofibroblasts: molecular crossdressers. Current Topics in Developmental Biology. 51: 91-107. PMID 11236717 DOI: 10.1016/S0070-2153(01)51003-0  0.62
2001 Olsson MC, Palmer BM, Leinwand LA, Moore RL. Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology. 280: H1136-44. PMID 11179057 DOI: 10.1152/Ajpheart.2001.280.3.H1136  0.348
2001 Allen DL, Harrison BC, Sartorius C, Byrnes WC, Leinwand LA. Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy. American Journal of Physiology. Cell Physiology. 280: C637-45. PMID 11171584 DOI: 10.1152/Ajpcell.2001.280.3.C637  0.315
2001 Allen DL, Leinwand LA. Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains. Developmental Biology. 229: 383-95. PMID 11150240 DOI: 10.1006/Dbio.2000.9974  0.349
2001 Freeman K, Colon-Rivera C, Olsson MC, Moore RL, Weinberger HD, Grupp IL, Vikstrom KL, Iaccarino G, Koch WJ, Leinwand LA. Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene. American Journal of Physiology. Heart and Circulatory Physiology. 280: H151-9. PMID 11123229 DOI: 10.1152/Ajpheart.2001.280.1.H151  0.372
2000 Carnes J, Frolova L, Zinnen S, Drugeon G, Phillippe M, Justesen J, Haenni AL, Leinwand L, Kisselev LL, Yarus M. Suppression of eukaryotic translation termination by selected RNAs Rna. 6: 1468-1479. PMID 11073222 DOI: 10.1017/S1355838200001242  0.665
2000 Allen DL, Harrison BC, Leinwand LA. Inactivation of myosin heavy chain genes in the mouse: diverse and unexpected phenotypes. Microscopy Research and Technique. 50: 492-9. PMID 10998638 DOI: 10.1002/1097-0029(20000915)50:6<492::Aid-Jemt6>3.0.Co;2-J  0.351
2000 Maass A, Leinwand LA. Animal models of hypertrophic cardiomyopathy Current Opinion in Cardiology. 15: 189-196. PMID 10952427 DOI: 10.1097/00001573-200005000-00012  0.349
2000 Buvoli M, Buvoli A, Leinwand LA. Suppression of nonsense mutations in cell culture and mice by multimerized suppressor tRNA genes Molecular and Cellular Biology. 20: 3116-3124. PMID 10757796 DOI: 10.1128/Mcb.20.9.3116-3124.2000  0.355
2000 Miyata S, Minobe W, Bristow MR, Leinwand LA. Myosin heavy chain isoform expression in the failing and nonfailing human heart Circulation Research. 86: 386-390. PMID 10700442 DOI: 10.1161/01.Res.86.4.386  0.357
2000 Tardiff JC, Hewett TE, Factor SM, Vikstrom KL, Robbins J, Leinwand LA. Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects American Journal of Physiology - Heart and Circulatory Physiology. 278. PMID 10666070 DOI: 10.1152/Ajpheart.2000.278.2.H412  0.39
1999 Welikson RE, Buck SH, Patel JR, Moss RL, Vikstrom KL, Factor SM, Miyata S, Weinberger HD, Leinwand LA. Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice. American Journal of Physiology. Heart and Circulatory Physiology. 276: H2148-H2158. PMID 29592415 DOI: 10.1152/Ajpheart.1999.276.6.H2148  0.4
1999 Lu BD, Allen DL, Leinwand LA, Lyons GE. Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development. Developmental Biology. 216: 312-26. PMID 10588881 DOI: 10.1006/Dbio.1999.9488  0.32
1999 Tardiff JC, Hewett TE, Palmer BM, Olsson C, Factor SM, Moore RL, Robbins J, Leinwand LA. Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 104: 469-81. PMID 10449439 DOI: 10.1172/Jci6067  0.392
1999 Weiss A, Schiaffino S, Leinwand LA. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: Implications for functional diversity Journal of Molecular Biology. 290: 61-75. PMID 10388558 DOI: 10.1006/Jmbi.1999.2865  0.334
1999 Weiss A, McDonough D, Wertman B, Acakpo-Satchivi L, Montgomery K, Kucherlapati R, Leinwand L, Krauter K. Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved. Proceedings of the National Academy of Sciences of the United States of America. 96: 2958-63. PMID 10077619 DOI: 10.1073/Pnas.96.6.2958  0.525
1998 Roopnarine O, Leinwand LA. Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy. Biophysical Journal. 75: 3023-30. PMID 9826622 DOI: 10.1016/S0006-3495(98)77743-4  0.358
1998 Tardiff JC, Factor SM, Tompkins BD, Hewett TE, Palmer BM, Moore RL, Schwartz S, Robbins J, Leinwand LA. A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 101: 2800-11. PMID 9637714 DOI: 10.1172/Jci2389  0.394
1998 Sartorius CA, Lu BD, Acakpo-Satchivi L, Jacobsen RP, Byrnes WC, Leinwand LA. Myosin heavy chains IIa and IId are functionally distinct in the mouse Journal of Cell Biology. 141: 943-953. PMID 9585413 DOI: 10.1083/Jcb.141.4.943  0.351
1998 Vikstrom KL, Bohlmeyer T, Factor SM, Leinwand LA. Hypertrophy, pathology, and molecular markers of cardiac pathogenesis Circulation Research. 82: 773-778. PMID 9562436 DOI: 10.1161/01.Res.82.7.773  0.37
1997 Nakao K, Minobe W, Roden R, Bristow MR, Leinwand LA. Myosin heavy chain gene expression in human heart failure Journal of Clinical Investigation. 100: 2362-2370. PMID 9410916 DOI: 10.1172/Jci119776  0.369
1997 Mayer DCG, Leinwand LA. Sarcomeric gene expression and contractility in myofibroblasts Journal of Cell Biology. 139: 1477-1484. PMID 9396753 DOI: 10.1083/Jcb.139.6.1477  0.328
1997 Acakpo-Satchivi LJ, Edelmann W, Sartorius C, Lu BD, Wahr PA, Watkins SC, Metzger JM, Leinwand L, Kucherlapati R. Growth and muscle defects in mice lacking adult myosin heavy chain genes. The Journal of Cell Biology. 139: 1219-29. PMID 9382868 DOI: 10.1083/Jcb.139.5.1219  0.535
1997 Kass-Eisler A, Leinwand LA. DNA- and adenovirus-mediated gene transfer into cardiac muscle Methods in Cell Biology. 423-437. PMID 9379963 DOI: 10.1016/S0091-679X(08)60390-8  0.374
1997 Li K, Zhang J, Buvoli M, Yan XD, Leinwand L, He H. Ochre suppressor transfer RNA restored dystrophin expression in mdx mice. Life Sciences. 61. PMID 9328234 DOI: 10.1016/S0024-3205(97)00714-5  0.343
1997 von Harsdorf R, Edwards JG, Shen YT, Kudej RK, Dietz R, Leinwand LA, Nadal-Ginard B, Vatner SF. Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload. The Journal of Clinical Investigation. 100: 1294-304. PMID 9276748 DOI: 10.1172/Jci119643  0.3
1997 Li K, Welikson RE, Vikstrom KL, Leinwand LA. Direct gene transfer into the mouse heart Journal of Molecular and Cellular Cardiology. 29: 1499-1504. PMID 9201634 DOI: 10.1006/Jmcc.1997.0389  0.375
1997 Vikstrom KL, Seiler SH, Sohn RL, Strauss M, Weiss A, Welikson RE, Leinwand LA. The vertebrate myosin heavy chain: Genetics and assembly properties Cell Structure and Function. 22: 123-129. PMID 9113398 DOI: 10.1247/Csf.22.123  0.313
1996 Weiss A, Leinwand LA. The mammalian myosin heavy chain gene family Annual Review of Cell and Developmental Biology. 12: 417-439. PMID 8970733 DOI: 10.1146/Annurev.Cellbio.12.1.417  0.376
1996 Vikstrom KL, Factor SM, Leinwand LA. Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy Molecular Medicine. 2: 556-567. PMID 8898372 DOI: 10.1007/Bf03401640  0.385
1996 Vikstrom KL, Leinwand LA. Contractile protein mutations and heart disease Current Opinion in Cell Biology. 8: 97-105. PMID 8791411 DOI: 10.1016/S0955-0674(96)80053-6  0.366
1996 Edwards JG, Lyons GE, Micales BK, Malhotra A, Factor S, Leinwand LA. Cardiomyopathy in transgenic myf5 mice. Circulation Research. 78: 379-87. PMID 8593696 DOI: 10.1161/01.Res.78.3.379  0.389
1995 Gardin JM, Siri FM, Kitsis RN, Edwards JG, Leinwand LA. Echocardiographic assessment of left ventricular mass and systolic function in mice. Circulation Research. 76: 907-14. PMID 7729009 DOI: 10.1161/01.Res.76.5.907  0.322
1995 Edwards JG, Harsdorf Rv, Shen Y, Nadal-Ginard B, Leinwand L, Vatner SF. Characterization of a factor mediating the pressure overload induction of ANF gene expression in the heart.: 25 Medicine and Science in Sports and Exercise. 27. DOI: 10.1249/00005768-199505001-00025  0.317
1994 Straceski AJ, Geisterfer-Lowrance A, Seidman CE, Seidman JG, Leinwand LA. Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy Proceedings of the National Academy of Sciences of the United States of America. 91: 589-593. PMID 8290568 DOI: 10.1073/Pnas.91.2.589  0.309
1994 Ogata I, Sáez CG, Greenwel P, Ponce Mde L, Geerts A, Leinwand LA, Rojkind M. Rat liver fat-storing cell lines express sarcomeric myosin heavy chain mRNA and protein. Cell Motility and the Cytoskeleton. 26: 125-32. PMID 8287498 DOI: 10.1002/Cm.970260204  0.331
1994 Buttrick PM, Kaplan M, Leinwand LA, Scheuer J. Alterations in gene expressin in the rat heart after chronic pathological and physiological loads Journal of Molecular and Cellular Cardiology. 26: 61-67. PMID 8196070 DOI: 10.1006/Jmcc.1994.1008  0.345
1994 Kaplan ML, Cheslow Y, Vikstrom K, Malhotra A, Geenen DL, Nakouzi A, Leinwand LA, Buttrick PM. Cardiac adaptations to chronic exercise in mice. The American Journal of Physiology. 267: H1167-73. PMID 8092282 DOI: 10.1152/Ajpheart.1994.267.3.H1167  0.385
1994 LeBlanc-Straceski JM, Fukui Y, Sohn RL, Spudich JA, Leinwand LA. Functional analysis of a cardiac myosin rod in Dictyostelium discoideum. Cell Motility and the Cytoskeleton. 27: 313-26. PMID 8069939 DOI: 10.1002/Cm.970270404  0.336
1994 Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S. Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle American Journal of Physiology-Cell Physiology. 267. PMID 7545970 DOI: 10.1152/Ajpcell.1994.267.6.C1723  0.329
1993 Buttrick PM, Kaplan ML, Kitsis RN, Leinwand LA. Distinct behavior of cardiac myosin heavy chain gene constructs in vivo: Discordance with in vitro results Circulation Research. 72: 1211-1217. PMID 8495550 DOI: 10.1161/01.Res.72.6.1211  0.363
1993 Vikstrom KL, Rovner AS, Saez CG, Bravo-Zehnder M, Straceski AJ, Leinwand LA. Sarcomeric myosin heavy chain expressed in nonmuscle cells forms thick filaments in the presence of substoichiometric amounts of light chains. Cell Motility and the Cytoskeleton. 26: 192-204. PMID 8293476 DOI: 10.1002/Cm.970260303  0.308
1993 Kass-Eisler A, Falck-Pedersen E, Alvira M, Rivera J, Buttrick PM, Wittenberg BA, Cipriani L, Leinwand LA. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo Proceedings of the National Academy of Sciences of the United States of America. 90: 11498-11502. PMID 8265580 DOI: 10.1073/Pnas.90.24.11498  0.339
1993 Hughes SM, Cho M, Karsch-Mizrachi I, Travis M, Silberstein L, Leinwand LA, Blau HM. Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle Developmental Biology. 158: 183-199. PMID 7687223 DOI: 10.1006/Dbio.1993.1178  0.328
1993 Liao L, Sindhwani R, Leinwand L, Diamond B, Factor S. Cardiac alpha-myosin heavy chains differ in their induction of myocarditis. Identification of pathogenic epitopes. Journal of Clinical Investigation. 92: 2877-2882. PMID 7504694 DOI: 10.1172/Jci116909  0.333
1992 Buttrick P, Malhotra A, Factor S, Greenen D, Leinwand L, Scheuer J. Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart. Circulation Research. 68: 645-52. PMID 1835908 DOI: 10.1161/01.Res.68.3.645  0.319
1992 Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L. Organization of the human skeletal myosin heavy chain gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 89: 12078-82. PMID 1465443 DOI: 10.1073/Pnas.89.24.12078  0.517
1991 Leinwand LA, Leiden JM. Gene transfer into cardiac myocytes in vivo. Trends in Cardiovascular Medicine. 1: 271-6. PMID 21239293 DOI: 10.1016/1050-1738(91)90042-D  0.38
1991 Kitsis RN, Buttrick PM, Mcnally EM, Kaplan ML, Leinwand LA. Hormonal modulation of a gene injected into rat heart in vivo Proceedings of the National Academy of Sciences of the United States of America. 88: 4138-4142. PMID 2034660 DOI: 10.1073/Pnas.88.10.4138  0.375
1991 McNally E, Sohn R, Frankel S, Leinwand L. Expression of myosin and actin in Escherichia coli. Methods in Enzymology. 196: 368-389. PMID 2034131 DOI: 10.1016/0076-6879(91)96033-N  0.316
1991 McNally EM, Bravo-Zehnder MM, Leinwand LA. Identification of sequences necessary for the association of cardiac myosin subunits Journal of Cell Biology. 113: 585-590. PMID 2016338 DOI: 10.1083/Jcb.113.3.585  0.311
1991 Fishman GI, Hertzberg EL, Spray DC, Leinwand LA. Expression of connexin43 in the developing rat heart. Circulation Research. 68: 782-7. PMID 1660362 DOI: 10.1161/01.Res.68.3.782  0.353
1991 Fishman GI, Eddy RL, Shows TB, Rosenthal L, Leinwand LA. The human connexin gene family of gap junction proteins: Distinct chromosomal locations but similar structures Genomics. 10: 250-256. PMID 1646158 DOI: 10.1016/0888-7543(91)90507-B  0.306
1991 Leblanc JM, Leinwand LA. The diversity of myosin-based contractile systems in eukaryotic cells Integrative and Comparative Biology. 31: 514-521. DOI: 10.1093/Icb/31.3.514  0.334
1990 Karsch-Mizrachi I, Feghali R, Shows TB, Leinwand LA. Generation of a full-length human perinatal myosin heavy-chain-encoding cDNA Gene. 89: 289-294. PMID 2373371 DOI: 10.1016/0378-1119(90)90020-R  0.345
1990 Saez CG, Myers JC, Shows TB, Leinwand LA. Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation. Proceedings of the National Academy of Sciences of the United States of America. 87: 1164-8. PMID 1967836 DOI: 10.1073/Pnas.87.3.1164  0.36
1990 Fishman GI, Spray DC, Leinwand LA. Molecular characterization and functional expression of the human cardiac gap junction channel. The Journal of Cell Biology. 111: 589-98. PMID 1696265 DOI: 10.1083/Jcb.111.2.589  0.339
1990 Buttrick PM, Kass A, Kitsis RN, Kaplan ML, Leinwand LA. Behavior of genes directly injected into the rat heart in vivo Circulation Research. 70: 193-198. PMID 1309314 DOI: 10.1161/01.Res.70.1.193  0.365
1989 Mcnally EM, Gianola KM, Leinwand LA. Complete nucleotide sequence of full length cDNA for rat α cardiac myosin hea chain Nucleic Acids Research. 17: 7527-7528. PMID 2798111 DOI: 10.1093/Nar/17.18.7527  0.317
1989 Karsch-Mizrachi I, Travis M, Blau H, Leinwand LA. Expression and DNA sequence analysis of a human embryonic skeletal muscle mvosin heavy chain gene Nucleic Acids Research. 17: 6167-6179. PMID 2771643 DOI: 10.1093/Nar/17.15.6167  0.363
1989 Mcnally EM, Buttrick PM, Leinwand LA. Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension Nucleic Acids Research. 17: 2753-2768. PMID 2717409 DOI: 10.1093/Nar/17.7.2753  0.365
1989 Feghali R, Leinwand LA. Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain Journal of Cell Biology. 108: 1791-1797. PMID 2715179 DOI: 10.1083/Jcb.108.5.1791  0.354
1989 McNally EM, Kraft R, Bravo-Zehnder M, Taylor DA, Leinwand LA. Full-length rat alpha and beta cardiac myosin heavy chain sequences. Comparisons suggest a molecular basis for functional differences. Journal of Molecular Biology. 210: 665-71. PMID 2614840 DOI: 10.1016/0022-2836(89)90141-1  0.308
1987 De Lozanne A, Berlot CH, Leinwand LA, Spudich JA. Expression in Escherichia coli of a functional Dictyostelium myosin tail fragment Journal of Cell Biology. 105: 2999-3005. PMID 3320060 DOI: 10.1083/Jcb.105.6.2999  0.324
1987 Saez LJ, Gianola KM, McNally EM, Feghali R, Eddy R, Shows TB, Leinwand LA. Human cardiac myosin heavy chain genes and their linkage in the genome Nucleic Acids Research. 15: 5443-5459. PMID 3037493 DOI: 10.1093/Nar/15.13.5443  0.381
1986 Warrick HM, De Lozanne A, Leinwand LA, Spudich JA. Conserved protein domains in a myosin heavy chain gene from Dictyostelium discoideum Proceedings of the National Academy of Sciences of the United States of America. 83: 9433-9437. PMID 3540939 DOI: 10.1073/Pnas.83.24.9433  0.34
1986 Schwartz CE, McNally E, Leinwand L, Skolnick MH. A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13. Cytogenetic and Genome Research. 43: 117-120. PMID 2877813 DOI: 10.1159/000132307  0.302
1986 Saez L, Leinwand LA. Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle Nucleic Acids Research. 14: 2951-2969. PMID 2421254 DOI: 10.1093/Nar/14.7.2951  0.364
1985 DeLozanne A, Lewis M, Spudich JA, Leinwand LA. Cloning and characterization of a nonmuscle myosin heavy chain cDNA Proceedings of the National Academy of Sciences of the United States of America. 82: 6807-6810. PMID 3901008 DOI: 10.1073/Pnas.82.20.6807  0.34
1983 Leinwand LA, Saez L, McNally E, Nadal-Ginard B. Isolation and characterization of human myosin heavy chain genes Proceedings of the National Academy of Sciences of the United States of America. 80: 3716-3720. PMID 6304733 DOI: 10.1073/Pnas.80.12.3716  0.339
1982 Krauter K, Leinwand L, D'Eustachio P, Ruddle F, Darnell JE. Structural genes of the mouse major urinary protein are on chromosome 4. The Journal of Cell Biology. 94: 414-7. PMID 7107707 DOI: 10.1083/Jcb.94.2.414  0.487
1979 Leinwand L, Nichols E, Ruddle FH. Assignment of the gene for glyoxylase I to mouse chromosome 17 by somatic cell genetics. Biochemical Genetics. 16: 659-66. PMID 569476 DOI: 10.1007/Bf00484722  0.474
1979 Kozak CA, Fournier REK, Leinwand LA, Ruddle FH. Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids Biochemical Genetics. 17: 23-34. PMID 454358 DOI: 10.1007/Bf00484471  0.46
1979 Swan D, D'Eustachio P, Leinwand L, Seidman J, Keithley D, Ruddle FH. Chromosomal assignment of the mouse kappa light chain genes. Proceedings of the National Academy of Sciences of the United States of America. 76: 2735-9. PMID 111241 DOI: 10.1073/Pnas.76.6.2735  0.477
1978 Leinwand LA, Ruddle FH. Assignment of the gene for dipeptidase 2 to Mus musculus chromosome 18 by somatic cell hybridization Biochemical Genetics. 16: 477-484. PMID 736882 DOI: 10.1007/Bf00484213  0.471
1978 Leinwand LA, Kozak CA, Ruddle FH. Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization Somatic Cell Genetics. 4: 233-240. PMID 566475 DOI: 10.1007/Bf01538987  0.446
1978 Ruddle NH, Conta BS, Leinwand L, Kozak C, Ruddle F, Besmer P, Baltimore D. Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5 Journal of Experimental Medicine. 148: 451-465. PMID 212501 DOI: 10.1084/Jem.148.2.451  0.46
1978 Leinwand L, Fournier RE, Nichols EA, Ruddle FH. Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Cytogenetics and Cell Genetics. 21: 77-85. PMID 206412 DOI: 10.1159/000130880  0.462
1978 Leinwand L, Strair R, Ruddle FH. Phenotypic and molecular expression of albumin in rat hepatoma x L cell hybrids. Experimental Cell Research. 115: 261-8. PMID 28957 DOI: 10.1016/0014-4827(78)90280-X  0.459
1977 Leinwand L, Ruddle FH. Stimulation of in vitro translation of messenger RNA by actinomycin D and cordycepin. Science (New York, N.Y.). 197: 381-3. PMID 17919 DOI: 10.1126/Science.17919  0.425
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