| Year |
Citation |
Score |
| 2023 |
Manieri E, Tie G, Malagola E, Seruggia D, Madha S, Maglieri A, Huang K, Fujiwara Y, Zhang K, Orkin SH, Wang TC, He R, McCarthy N, Shivdasani RA. Role of PDGFRA cells and a CD55 PDGFRA fraction in the gastric mesenchymal niche. Nature Communications. 14: 7978. PMID 38042929 DOI: 10.1038/s41467-023-43619-y |
0.749 |
|
| 2023 |
Li BE, Li GY, Cai W, Zhu Q, Seruggia D, Fujiwara Y, Vakoc CR, Orkin S. In vivo CRISPR/Cas9 Screening Identifies Pbrm1 as a Regulator of Mouse Myeloid Leukemia Development. Blood Advances. PMID 37428871 DOI: 10.1182/bloodadvances.2022009455 |
0.822 |
|
| 2023 |
Lu HY, Orkin SH, Sankaran VG. Fetal Hemoglobin Regulation in Beta-Thalassemia. Hematology/Oncology Clinics of North America. 37: 301-312. PMID 36907604 DOI: 10.1016/j.hoc.2022.12.002 |
0.505 |
|
| 2023 |
Manieri E, Tie G, Seruggia D, Madha S, Maglieri A, Huang K, Fujiwara Y, Zhang K, Orkin SH, He R, McCarthy N, Shivdasani RA. Defining the structure, signals, and cellular elements of the gastric mesenchymal niche. Biorxiv : the Preprint Server For Biology. PMID 36798304 DOI: 10.1101/2023.02.11.527728 |
0.741 |
|
| 2022 |
Mehta S, Buyanbat A, Kai Y, Karayel O, Goldman SR, Seruggia D, Zhang K, Fujiwara Y, Donovan KA, Zhu Q, Yang H, Nabet B, Gray NS, Mann M, Fischer ES, ... ... Orkin SH, et al. Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chemical Biology. PMID 35839780 DOI: 10.1016/j.chembiol.2022.06.007 |
0.762 |
|
| 2022 |
Somuncular E, Hauenstein J, Khalkar P, Johansson AS, Dumral Ö, Frengen NS, Gustafsson C, Mocci G, Su TY, Brouwer H, Trautmann CL, Vanlandewijck M, Orkin SH, Månsson R, Luc S. CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells. Stem Cell Reports. 17: 1546-1560. PMID 35714596 DOI: 10.1016/j.stemcr.2022.05.014 |
0.339 |
|
| 2022 |
Ellegast JM, Alexe G, Hamze A, Lin S, Uckelmann HJ, Rauch PJ, Pimkin M, Ross LS, Dharia NV, Robichaud AL, Saur Conway A, Khalid D, Perry JA, Wunderlich M, Benajiba L, ... ... Orkin SH, et al. Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts. Cancer Discovery. PMID 35405016 DOI: 10.1158/2159-8290.CD-21-0956 |
0.302 |
|
| 2022 |
Ludwig L, Lareau CA, Bao EL, Liu N, Utsugisawa T, Tseng AM, Myers SA, Verboon JM, Ulirsch JC, Luo W, Muus C, Fiorini C, Olive ME, Vockley CM, Munschauer M, ... ... Orkin S, et al. A Congenital Anemia Reveals Distinct Targeting Mechanisms for Master Transcription Factor GATA1. Blood. PMID 35030251 DOI: 10.1182/blood.2021013753 |
0.611 |
|
| 2021 |
Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA. Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Genes & Development. PMID 34969824 DOI: 10.1101/gad.348983.121 |
0.737 |
|
| 2021 |
Cha HJ, Uyan Ö, Kai Y, Liu T, Zhu Q, Tothova Z, Botten GA, Xu J, Yuan GC, Dekker J, Orkin SH. Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture. Nature Communications. 12: 6241. PMID 34716321 DOI: 10.1038/s41467-021-26574-4 |
0.365 |
|
| 2021 |
Beyaz S, Chung C, Mou H, Bauer-Rowe KE, Xifaras ME, Ergin I, Dohnalova L, Biton M, Shekhar K, Eskiocak O, Papciak K, Ozler K, Almeqdadi M, Yueh B, Fein M, ... ... Orkin SH, et al. Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis. Cell Stem Cell. PMID 34529935 DOI: 10.1016/j.stem.2021.08.007 |
0.77 |
|
| 2021 |
Shen Y, Verboon JM, Zhang Y, Liu N, Kim YJ, Marglous S, Nandakumar SK, Voit RA, Fiorini C, Ejaz A, Basak A, Orkin SH, Xu J, Sankaran VG. A unified model of human hemoglobin switching through single-cell genome editing. Nature Communications. 12: 4991. PMID 34404810 DOI: 10.1038/s41467-021-25298-9 |
0.578 |
|
| 2021 |
Barthlott T, Handel AE, Teh HY, Wirasinha RC, Hafen K, Žuklys S, Roch B, Orkin SH, de Villartay JP, Daley SR, Holländer GA. Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2. Nature Communications. 12: 3933. PMID 34168132 DOI: 10.1038/s41467-021-24158-w |
0.312 |
|
| 2020 |
Terzi Cizmecioglu N, Huang J, Keskin EG, Wang X, Esen I, Chen F, Orkin SH. ARID4B is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit. The Journal of Biological Chemistry. 295: 17738-17751. PMID 33454011 DOI: 10.1074/jbc.RA120.015534 |
0.412 |
|
| 2020 |
Terzi Cizmecioglu N, Huang J, Keskin EG, Wang X, Esen I, Chen F, Orkin SH. Arid4b is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit. The Journal of Biological Chemistry. PMID 33060200 DOI: 10.1074/jbc.RA120.015534 |
0.402 |
|
| 2020 |
Cai W, Huang J, Zhu Q, Li BE, Seruggia D, Zhou P, Nguyen M, Fujiwara Y, Xie H, Yang Z, Hong D, Ren P, Xu J, Pu WT, Yuan GC, ... Orkin SH, et al. Enhancer dependence of cell-type-specific gene expression increases with developmental age. Proceedings of the National Academy of Sciences of the United States of America. PMID 32817427 DOI: 10.1073/Pnas.2008672117 |
0.798 |
|
| 2020 |
Bowling S, Sritharan D, Osorio FG, Nguyen M, Cheung P, Rodriguez-Fraticelli A, Patel S, Yuan WC, Fujiwara Y, Li BE, Orkin SH, Hormoz S, Camargo FD. An Engineered CRISPR-Cas9 Mouse Line for Simultaneous Readout of Lineage Histories and Gene Expression Profiles in Single Cells. Cell. PMID 32413320 DOI: 10.1016/J.Cell.2020.04.048 |
0.446 |
|
| 2020 |
Liu X, Chen Y, Zhang Y, Liu Y, Liu N, Botten GA, Cao H, Orkin SH, Zhang MQ, Xu J. Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9. Genome Biology. 21: 59. PMID 32138752 DOI: 10.1186/S13059-020-01973-W |
0.334 |
|
| 2020 |
Christodoulou C, Spencer JA, Yeh SA, Turcotte R, Kokkaliaris KD, Panero R, Ramos A, Guo G, Seyedhassantehrani N, Esipova TV, Vinogradov SA, Rudzinskas S, Zhang Y, Perkins AS, Orkin SH, et al. Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. PMID 32025033 DOI: 10.1038/S41586-020-1971-Z |
0.331 |
|
| 2020 |
Basak A, Munschauer M, Lareau CA, Montbleau KE, Ulirsch JC, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, Wu X, Gehrke L, Rice CM, An X, Christou HA, ... ... Orkin SH, et al. Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nature Genetics. PMID 31959994 DOI: 10.1038/S41588-019-0568-7 |
0.618 |
|
| 2019 |
Debruyne DN, Dries R, Sengupta S, Seruggia D, Gao Y, Sharma B, Huang H, Moreau L, McLane M, Day DS, Marco E, Chen T, Gray NS, Wong KK, Orkin SH, et al. BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells. Nature. PMID 31391581 DOI: 10.1038/S41586-019-1472-0 |
0.784 |
|
| 2019 |
Sher F, Hossain M, Seruggia D, Schoonenberg VAC, Yao Q, Cifani P, Dassama LMK, Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver MC, ... ... Orkin SH, et al. Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis. Nature Genetics. PMID 31253978 DOI: 10.1038/S41588-019-0453-4 |
0.759 |
|
| 2019 |
Seruggia D, Oti M, Tripathi P, Canver MC, LeBlanc L, Di Giammartino DC, Bullen MJ, Nefzger CM, Sun YBY, Farouni R, Polo JM, Pinello L, Apostolou E, Kim J, Orkin SH, et al. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Molecular Cell. PMID 31005419 DOI: 10.1016/J.Molcel.2019.03.025 |
0.806 |
|
| 2019 |
Jadhav U, Cavazza A, Banerjee KK, Xie H, O'Neill NK, Saenz-Vash V, Herbert Z, Madha S, Orkin SH, Zhai H, Shivdasani RA. Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA. Molecular Cell. PMID 30905509 DOI: 10.1016/J.Molcel.2019.02.024 |
0.363 |
|
| 2019 |
Pimkin M, Ferrucio JX, Dharia NV, Harada T, Kossenkov A, Elsarrag S, Ewers J, Lin CY, Stegmaier K, Orkin SH. Core Transcriptional Regulatory Circuitries in AML Blood. 134: 280-280. DOI: 10.1182/Blood-2019-129297 |
0.346 |
|
| 2018 |
Barros-Silva JD, Linn DE, Steiner I, Guo G, Ali A, Pakula H, Ashton G, Peset I, Brown M, Clarke NW, Bronson RT, Yuan GC, Orkin SH, Li Z, Baena E. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Reports. 25: 3504-3518.e6. PMID 30566873 DOI: 10.1016/J.Celrep.2018.11.069 |
0.37 |
|
| 2018 |
LeBlanc L, Lee BK, Yu AC, Kim M, Kambhampati AV, Dupont SM, Seruggia D, Ryu BU, Orkin SH, Kim J. Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation. Elife. 7. PMID 30561326 DOI: 10.7554/Elife.40167 |
0.813 |
|
| 2018 |
Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, ... ... Orkin SH, et al. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of Biological Chemistry. PMID 30366982 DOI: 10.1074/Jbc.Ra118.002742 |
0.455 |
|
| 2018 |
Orkin SH, Bauer DE. Emerging Genetic Therapy for Sickle Cell Disease. Annual Review of Medicine. PMID 30355263 DOI: 10.1146/Annurev-Med-041817-125507 |
0.37 |
|
| 2018 |
Singarapu N, Ma K, Reeh KAG, Shen J, Lancaster JN, Yi S, Xie H, Orkin SH, Manley NR, Ehrlich LIR, Jiang N, Richie ER. Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment. Scientific Reports. 8: 14335. PMID 30254371 DOI: 10.1038/S41598-018-32729-Z |
0.482 |
|
| 2018 |
Michalak EM, Milevskiy MJG, Joyce RM, Dekkers JF, Jamieson PR, Pal B, Dawson CA, Hu Y, Orkin SH, Alexander WS, Lindeman GJ, Smyth GK, Visvader JE. Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids. Plos Biology. 16: e2004986. PMID 30080881 DOI: 10.1371/Journal.Pbio.2004986 |
0.427 |
|
| 2018 |
Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... ... Orkin SH, et al. Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. PMID 29849139 DOI: 10.1038/S41586-018-0187-Y |
0.727 |
|
| 2018 |
MacLean GA, McEldoon J, Huang J, Allred J, Canver MC, Orkin SH. Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells. Scientific Reports. 8: 8001. PMID 29789608 DOI: 10.1038/S41598-018-26123-Y |
0.42 |
|
| 2018 |
Lu TT, Heyne S, Dror E, Casas E, Leonhardt L, Boenke T, Yang CH, Sagar, Arrigoni L, Dalgaard K, Teperino R, Enders L, Selvaraj M, Ruf M, Raja SJ, ... ... Orkin SH, et al. The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes. Cell Metabolism. PMID 29754954 DOI: 10.1016/J.Cmet.2018.04.013 |
0.378 |
|
| 2018 |
Liu N, Hargreaves VV, Zhu Q, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan GC, Bauer DE, Xu J, Bulyk ML, ... Orkin SH, et al. Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. Cell. PMID 29606353 DOI: 10.1016/J.Cell.2018.03.016 |
0.429 |
|
| 2018 |
Huang J, Li K, Cai W, Liu X, Zhang Y, Orkin SH, Xu J, Yuan GC. Dissecting super-enhancer hierarchy based on chromatin interactions. Nature Communications. 9: 943. PMID 29507293 DOI: 10.1038/S41467-018-03279-9 |
0.354 |
|
| 2018 |
Yamauchi T, Masuda T, Canver MC, Seiler M, Semba Y, Shboul M, Al-Raqad M, Maeda M, Schoonenberg VAC, Cole MA, Macias-Trevino C, Ishikawa Y, Yao Q, Nakano M, Arai F, ... Orkin SH, et al. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS. Cancer Cell. PMID 29478914 DOI: 10.1016/J.Ccell.2018.01.012 |
0.347 |
|
| 2018 |
Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, Saadatpour A, Zhou Z, Chen H, Ye F, Huang D, Xu Y, Huang W, Jiang M, Jiang X, ... ... Orkin SH, et al. Mapping the Mouse Cell Atlas by Microwell-Seq. Cell. 172: 1091-1107.e17. PMID 29474909 DOI: 10.1016/J.Cell.2018.02.001 |
0.379 |
|
| 2018 |
Lessard S, Beaudoin M, Orkin SH, Bauer DE, Lettre G. 14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts. Human Molecular Genetics. PMID 29432581 DOI: 10.1093/Hmg/Ddy051 |
0.404 |
|
| 2018 |
Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. PMID 29342143 DOI: 10.1038/Nature25435 |
0.458 |
|
| 2018 |
LeBlanc L, Lee B, Yu AC, Kim M, Kambhampati AV, Dupont SM, Seruggia D, Ryu BU, Orkin SH, Kim J. Author response: Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation Elife. DOI: 10.7554/Elife.40167.035 |
0.8 |
|
| 2018 |
Yien YY, Shi J, Chen C, Cheung J, Grillo A, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King M, Ablain J, Zon LI, Palis J, Burke M, ... ... Orkin SH, et al. Target of Erythropoietin, Fam210b, Regulates Erythroid Heme Synthesis By Control of Mitochondrial Iron Import and Regulation of Fech Activity Blood. 132: 849-849. DOI: 10.1182/Blood-2018-99-120299 |
0.468 |
|
| 2018 |
Basak A, Munschauer M, Ulirsch JC, Montbleau KE, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, Wu X, Gehrke L, Rice CM, An X, Christou HA, Narla M, ... ... Orkin SH, et al. Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation Blood. 132: 412-412. DOI: 10.1182/Blood-2018-99-117440 |
0.652 |
|
| 2018 |
Rosanwo TO, Kinney M, Clark MA, Vo LT, Rowe RG, Archer NM, Heeney MM, Schlaeger T, Bauer DE, Fleming MD, Duraisingh MT, Orkin SH, Brugnara C, North T, Daley GQ. Optimized Beta-Globin Expression and Enucleation from Induced Red Blood Cells for In Vitro Modeling of Sickle Cell Disease Blood. 132: 2359-2359. DOI: 10.1182/Blood-2018-99-114136 |
0.461 |
|
| 2017 |
Pittermann E, Lachmann N, MacLean G, Emmrich S, Ackermann M, Göhring G, Schlegelberger B, Welte K, Schambach A, Heckl D, Orkin SH, Cantz T, Klusmann JH. Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. Blood Advances. 1: 903-914. PMID 29296734 DOI: 10.1182/Bloodadvances.2016003798 |
0.432 |
|
| 2017 |
Vinjamur DS, Bauer DE, Orkin SH. Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies. British Journal of Haematology. PMID 29193029 DOI: 10.1111/Bjh.15038 |
0.439 |
|
| 2017 |
Moody JD, Levy S, Mathieu J, Xing Y, Kim W, Dong C, Tempel W, Robitaille AM, Dang LT, Ferreccio A, Detraux D, Sidhu S, Zhu L, Carter L, Xu C, ... ... Orkin SH, et al. First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proceedings of the National Academy of Sciences of the United States of America. PMID 28864533 DOI: 10.1073/Pnas.1706907114 |
0.415 |
|
| 2017 |
Hsu JH, Hubbell-Engler B, Adelmant G, Huang J, Joyce CE, Vazquez F, Weir BA, Montgomery P, Tsherniak A, Giacomelli AO, Perry JA, Trowbridge J, Fujiwara Y, Cowley GS, Xie H, ... ... Orkin SH, et al. Prmt1-mediated translation regulation is a crucial vulnerability of cancer. Cancer Research. PMID 28655788 DOI: 10.1158/0008-5472.Can-17-0216 |
0.349 |
|
| 2017 |
Chung J, Wittig JG, Ghamari A, Maeda M, Dailey TA, Bergonia H, Kafina MD, Coughlin EE, Minogue CE, Hebert AS, Li L, Kaplan J, Lodish HF, Bauer DE, Orkin SH, et al. Erythropoietin signaling regulates heme biosynthesis. Elife. 6. PMID 28553927 DOI: 10.7554/Elife.24767 |
0.348 |
|
| 2017 |
Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I. Challenges and emerging directions in single-cell analysis. Genome Biology. 18: 84. PMID 28482897 DOI: 10.1186/S13059-017-1218-Y |
0.357 |
|
| 2017 |
Xie Y, Koch ML, Zhang X, Hamblen MJ, Godinho FJ, Fujiwara Y, Xie H, Klusmann JH, Orkin SH, Li Z. Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells. Stem Cells (Dayton, Ohio). PMID 28436588 DOI: 10.1002/Stem.2627 |
0.489 |
|
| 2017 |
Ai S, Peng Y, Li C, Gu F, Yu X, Yue Y, Ma Q, Chen J, Lin Z, Zhou P, Xie H, Prendiville TW, Zheng W, Liu Y, Orkin SH, et al. EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent. Elife. 6. PMID 28394251 DOI: 10.7554/Elife.24570 |
0.417 |
|
| 2017 |
Erb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, ... ... Orkin SH, et al. Transcription control by the ENL YEATS domain in acute leukaemia. Nature. PMID 28241139 DOI: 10.1038/Nature21688 |
0.402 |
|
| 2017 |
Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, ... ... Orkin SH, et al. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nature Genetics. PMID 28218758 DOI: 10.1038/Ng.3793 |
0.314 |
|
| 2017 |
Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, ... ... Orkin SH, et al. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Research. PMID 28128194 DOI: 10.1038/Cr.2017.17 |
0.447 |
|
| 2016 |
Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, ... Orkin SH, et al. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nature Immunology. PMID 27992400 DOI: 10.1038/Ni.3644 |
0.815 |
|
| 2016 |
Smith EC, Luc S, Croney DM, Woodworth MB, Greig LC, Fujiwara Y, Nguyen M, Sher F, Macklis JD, Bauer DE, Orkin SH. Strict in vivo specificity of the Bcl11a erythroid enhancer. Blood. PMID 27707736 DOI: 10.1182/Blood-2016-08-736249 |
0.423 |
|
| 2016 |
Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biology. 17: 201. PMID 27687735 DOI: 10.1186/S13059-016-1062-5 |
0.405 |
|
| 2016 |
Luc S, Huang J, McEldoon JL, Somuncular E, Li D, Rhodes C, Mamoor S, Hou S, Xu J, Orkin SH. Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype. Cell Reports. 16: 3181-94. PMID 27653684 DOI: 10.1016/J.Celrep.2016.08.064 |
0.459 |
|
| 2016 |
Xie H, Peng C, Huang J, Li BE, Kim W, Smith EC, Fujiwara Y, Qi J, Cheloni G, Das PP, Nguyen M, Li S, Bradner JE, Orkin SH. Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2. Cancer Discovery. PMID 27630126 DOI: 10.1158/2159-8290.Cd-15-1439 |
0.359 |
|
| 2016 |
Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. The Journal of Clinical Investigation. 126: 3868-3878. PMID 27599293 DOI: 10.1172/Jci87885 |
0.453 |
|
| 2016 |
Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Reports. PMID 27524622 DOI: 10.1016/J.Celrep.2016.07.056 |
0.495 |
|
| 2016 |
Shimizu T, Kubovcakova L, Nienhold R, Zmajkovic J, Meyer SC, Hao-Shen H, Geier F, Dirnhofer S, Guglielmelli P, Vannucchi AM, Feenstra JD, Kralovics R, Orkin SH, Skoda RC. Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis. The Journal of Experimental Medicine. PMID 27401344 DOI: 10.1084/Jem.20151136 |
0.465 |
|
| 2016 |
Liddicoat BJ, Hartner JC, Piskol R, Ramaswami G, Chalk AM, Kingsley PD, Sankaran VG, Wall M, Purton LE, Seeburg PH, Palis J, Orkin SH, Lu J, Li JB, Walkley CR. Adenosine-to-insoine RNA editing by ADAR1 is essential for normal murine erythropoiesis. Experimental Hematology. PMID 27373493 DOI: 10.1016/J.Exphem.2016.06.250 |
0.601 |
|
| 2016 |
Balbach ST, Orkin SH. An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation. Cancer Discovery. 6: 700-2. PMID 27371576 DOI: 10.1158/2159-8290.Cd-16-0564 |
0.309 |
|
| 2016 |
Smith EC, Orkin SH. Hemoglobin genetics: recent contributions of GWAS and gene editing. Human Molecular Genetics. PMID 27340226 DOI: 10.1093/Hmg/Ddw170 |
0.426 |
|
| 2016 |
Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nature Communications. 7: 12047. PMID 27329220 DOI: 10.1038/Ncomms12047 |
0.398 |
|
| 2016 |
Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. Mathematical modeling of erythrocyte chimerism informs genetic intervention strategies for sickle cell disease. American Journal of Hematology. 91: 931-7. PMID 27299299 DOI: 10.1002/Ajh.24449 |
0.422 |
|
| 2016 |
Orkin SH, Reilly P. MEDICINE. Paying for future success in gene therapy. Science (New York, N.Y.). 352: 1059-61. PMID 27230368 DOI: 10.1126/Science.Aaf4770 |
0.309 |
|
| 2016 |
Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA. Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. PMID 27212235 DOI: 10.1016/J.Cell.2016.04.031 |
0.443 |
|
| 2016 |
Kim PG, Canver MC, Rhee C, Ross SJ, Harriss JV, Tu HC, Orkin SH, Tucker HO, Daley GQ. Interferon-alpha signaling promotes embryonic HSC maturation. Blood. PMID 27095787 DOI: 10.1182/Blood-2016-01-689281 |
0.786 |
|
| 2016 |
Canver MC, Orkin SH. Customizing the genome as therapy for the β-hemoglobinopathies. Blood. PMID 27053533 DOI: 10.1182/Blood-2016-01-678128 |
0.313 |
|
| 2016 |
Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, ... ... Orkin SH, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 531: 53-8. PMID 26935695 DOI: 10.1038/Nature17173 |
0.781 |
|
| 2016 |
Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna JN, Riedel SS, Zhu N, Xie H, Orkin SH, Armstrong SA, Bernt KM, Neff T. Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell Reports. PMID 26904942 DOI: 10.1016/J.Celrep.2016.01.064 |
0.468 |
|
| 2016 |
Orkin SH. Recent advances in globin research using genome-wide association studies and gene editing. Annals of the New York Academy of Sciences. PMID 26866328 DOI: 10.1111/Nyas.13001 |
0.348 |
|
| 2016 |
Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, ... ... Orkin SH, et al. Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science (New York, N.Y.). 351: 285-9. PMID 26816381 DOI: 10.1126/Science.Aad3312 |
0.421 |
|
| 2016 |
Guo G, Pinello L, Han X, Lai S, Shen L, Lin TW, Zou K, Yuan GC, Orkin SH. Serum-Based Culture Conditions Provoke Gene Expression Variability in Mouse Embryonic Stem Cells as Revealed by Single-Cell Analysis. Cell Reports. PMID 26804902 DOI: 10.1016/J.Celrep.2015.12.089 |
0.438 |
|
| 2016 |
Huang J, Liu X, Li D, Shao Z, Cao H, Zhang Y, Trompouki E, Bowman TV, Zon LI, Yuan GC, Orkin SH, Xu J. Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis. Developmental Cell. 36: 9-23. PMID 26766440 DOI: 10.1016/J.Devcel.2015.12.014 |
0.568 |
|
| 2016 |
Hoban MD, Orkin SH, Bauer DE. Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease. Blood. PMID 26758916 DOI: 10.1182/Blood-2015-09-618587 |
0.357 |
|
| 2016 |
Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland K, Hulsman D, Citterio E, Orkin S, Berns A, Lohuizen Mv. Abstract IA05: Polycomb repressive complex-2 is a barrier to Kras-driven inflammation and epithelial-mesenchymal transition in non-small cell lung cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Ia05 |
0.356 |
|
| 2016 |
Hsu JH, Hubbell-Engler B, Adelmant G, Perry J, Cowley G, Marto J, Orkin SH. Abstract PR03: Prmt1 and Prmt1-dependent translation initiation are critical vulnerabilities of osteosarcoma Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-Pr03 |
0.386 |
|
| 2016 |
Linn DE, Barros-Silva J, Guo G, Brown M, Ashton G, Clarke NW, Yuan G, Orkin SH, Baena E, Li Z. Abstract LB-275: Single cell analysis identified LY6D as a novel marker of castration-resistant multipotent luminal progenitors Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-275 |
0.36 |
|
| 2016 |
Altrock PM, Brendel C, Renella R, Orkin SH, Williams DA, Michor F. 314. Mathematical Modeling of Erythrocyte Chimerism Informs Clinical Strategies for Sickle Cell Disease Molecular Therapy. 24: S126-S127. DOI: 10.1016/S1525-0016(16)33123-9 |
0.402 |
|
| 2016 |
Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim Y, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. 282. Circumventing Hematopoietic Toxicities and Reversing Sickle Phenotype by Lineage-Specific BCL11A Knock Down and γ-Globin Induction Molecular Therapy. 24: S113. DOI: 10.1016/S1525-0016(16)33091-X |
0.484 |
|
| 2016 |
Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland KD, Hulsman D, Citterio E, Orkin S, Berns A, van Lohuizen M. Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer Cancer Cell. 29: 17-31. DOI: 10.1016/J.Ccell.2015.12.006 |
0.387 |
|
| 2015 |
Yin J, Leavenworth JW, Li Y, Luo Q, Xie H, Liu X, Huang S, Yan H, Fu Z, Zhang LY, Zhang L, Hao J, Wu X, Deng X, Roberts CW, ... Orkin SH, et al. Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26668377 DOI: 10.1073/Pnas.1521740112 |
0.405 |
|
| 2015 |
Kim J, Singh AK, Takata Y, Lin K, Shen J, Lu Y, Kerenyi MA, Orkin SH, Chen T. LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nature Communications. 6: 10116. PMID 26626423 DOI: 10.1038/Ncomms10116 |
0.343 |
|
| 2015 |
Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nature Medicine. PMID 26552009 DOI: 10.1038/Nm.3968 |
0.313 |
|
| 2015 |
Miles WO, Lepesant JM, Bourdeaux J, Texier M, Kerenyi MA, Nakakido M, Hamamoto R, Orkin SH, Dyson NJ, Di Stefano L. The LSD1 family of histone demethylases and the PUMILIO post-transcriptional repressor function in a complex regulatory feedback loop. Molecular and Cellular Biology. PMID 26438601 DOI: 10.1128/Mcb.00755-15 |
0.375 |
|
| 2015 |
Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, ... ... Orkin SH, et al. Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. PMID 26385351 DOI: 10.1182/Blood-2015-07-659276 |
0.779 |
|
| 2015 |
Bauer DE, Orkin SH. Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin. Current Opinion in Genetics & Development. 33: 62-70. PMID 26375765 DOI: 10.1016/J.Gde.2015.08.001 |
0.403 |
|
| 2015 |
Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, ... ... Orkin SH, et al. BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. Nature. PMID 26375006 DOI: 10.1038/Nature15521 |
0.348 |
|
| 2015 |
Vierstra J, Reik A, Chang KH, Stehling-Sun S, Zhou Y, Hinkley SJ, Paschon DE, Zhang L, Psatha N, Bendana YR, O'Neil CM, Song AH, Mich AK, Liu PQ, Lee G, ... ... Orkin SH, et al. Functional footprinting of regulatory DNA. Nature Methods. PMID 26322838 DOI: 10.1038/Nmeth.3554 |
0.326 |
|
| 2015 |
Renneville A, Van Galen P, Canver MC, McConkey M, Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, Ebert BL. EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression. Blood. 126: 1930-9. PMID 26320100 DOI: 10.1182/Blood-2015-06-649087 |
0.47 |
|
| 2015 |
Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, ... ... Orkin SH, et al. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Reports. 12: 1456-1470. PMID 26299972 DOI: 10.1016/J.Celrep.2015.07.053 |
0.791 |
|
| 2015 |
Danis E, Yamauchi T, Echanique K, Haladyna J, Kalkur R, Riedel S, Zhu N, Xie H, Bernt KM, Orkin SH, Armstrong SA, Neff T. Inactivation of Eed Impedes MLL-AF9 Mediated Leukemogenesis Through Cdkn2a-Dependent and Cdkn2a-Independent Mechanisms in a Murine Model. Experimental Hematology. PMID 26118502 DOI: 10.1016/J.Exphem.2015.06.005 |
0.425 |
|
| 2015 |
Guda S, Brendel C, Renella R, Du P, Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J, de Boer H, Root DE, Milsom MD, Orkin SH, Gregory RI, et al. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 1465-74. PMID 26080908 DOI: 10.1038/Mt.2015.113 |
0.327 |
|
| 2015 |
Ma KH, Hung HA, Srinivasan R, Xie H, Orkin SH, Svaren J. Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8640-52. PMID 26041929 DOI: 10.1523/Jneurosci.2257-14.2015 |
0.349 |
|
| 2015 |
Canver MC, Bauer DE, Orkin SH. Embryonic stem cells as sources of donor-independent platelets. The Journal of Clinical Investigation. 125: 2261-3. PMID 25961451 DOI: 10.1172/Jci82348 |
0.393 |
|
| 2015 |
Basak A, Hancarova M, Ulirsch JC, Balci TB, Trkova M, Pelisek M, Vlckova M, Muzikova K, Cermak J, Trka J, Dyment DA, Orkin SH, Daly MJ, Sedlacek Z, Sankaran VG. BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. The Journal of Clinical Investigation. 125: 2363-8. PMID 25938782 DOI: 10.1172/Jci81163 |
0.602 |
|
| 2015 |
Yin Y, Yan P, Lu J, Song G, Zhu Y, Li Z, Zhao Y, Shen B, Huang X, Zhu H, Orkin SH, Shen X. Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation. Cell Stem Cell. 16: 504-16. PMID 25891907 DOI: 10.1016/J.Stem.2015.03.007 |
0.433 |
|
| 2015 |
Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, et al. The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability. Science Signaling. 8: ra34. PMID 25872869 DOI: 10.1126/Scisignal.Aaa5903 |
0.377 |
|
| 2015 |
Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. The Journal of Experimental Medicine. 212: 633-48. PMID 25870201 DOI: 10.1084/Jem.20141514 |
0.527 |
|
| 2015 |
Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, et al. Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling. Elife. 4. PMID 25714926 DOI: 10.7554/Elife.05544 |
0.565 |
|
| 2015 |
Maier VK, Feeney CM, Taylor JE, Creech AL, Qiao JW, Szanto A, Das PP, Chevrier N, Cifuentes-Rojas C, Orkin SH, Carr SA, Jaffe JD, Mertins P, Lee JT. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Molecular & Cellular Proteomics : McP. 14: 1435-46. PMID 25680957 DOI: 10.1074/Mcp.M114.044586 |
0.352 |
|
| 2015 |
Xu J, Shao Z, Li D, Xie H, Kim W, Huang J, Taylor JE, Pinello L, Glass K, Jaffe JD, Yuan GC, Orkin SH. Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular Cell. 57: 304-16. PMID 25578878 DOI: 10.1016/J.Molcel.2014.12.009 |
0.473 |
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| 2015 |
Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerényi MA, Sasidharan R, Rubbi L, Fujiwara Y, Pellegrini M, Orkin SH, Kurdistani SK, Mikkola HK. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. The Embo Journal. 34: 759-77. PMID 25564442 DOI: 10.15252/Embj.201490542 |
0.416 |
|
| 2015 |
Bauer DE, Canver MC, Orkin SH. Generation of genomic deletions in mammalian cell lines via CRISPR/Cas9. Journal of Visualized Experiments : Jove. PMID 25549070 DOI: 10.3791/52118 |
0.328 |
|
| 2015 |
Lin MI, Price EN, Boatman S, Hagedorn EJ, Trompouki E, Satishchandran S, Carspecken CW, Uong A, DiBiase A, Yang S, Canver MC, Dahlberg A, Lu Z, Zhang CC, Orkin SH, et al. Author response: Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling Elife. DOI: 10.7554/Elife.05544.021 |
0.428 |
|
| 2015 |
Bauer DE, Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, ... ... Orkin SH, et al. Crispr-Cas9 Saturating Mutagenesis Reveals an Achilles Heel in the BCL11A Erythroid Enhancer for Fetal Hemoglobin Induction (by Genome Editing) Blood. 126: 638-638. DOI: 10.1182/Blood.V126.23.638.638 |
0.43 |
|
| 2015 |
Perez-Ladaga A, Xie H, Orkin SH, Sykes DB, Ebert BL, Bejar R. Neutrophils Derived from Ezh2 -/- Progenitor Cells Demonstrate Aberrant Erythroid Lineage Gene Expression Blood. 126: 4112-4112. DOI: 10.1182/Blood.V126.23.4112.4112 |
0.467 |
|
| 2015 |
Yien YY, Chen C, Shi J, Li L, Bauer DE, Huston N, Kingsley PD, Ablain J, Zon LI, Palis J, Orkin SH, Kaplan J, Phillips JD, Lodish HF, Paw B. Fam210b Is Required for Optimal Cellular and Mitochondrial Iron Uptake during Erythroid Differentiation Blood. 126: 405-405. DOI: 10.1182/Blood.V126.23.405.405 |
0.494 |
|
| 2015 |
Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell APW, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu R, Kurita R, Nakamura Y, Xu J, Higgs DR, ... ... Orkin SH, et al. The LRF/ZBTB7A Transcription Factor Is a BCL11A-Independent Repressor of Fetal Hemoglobin Blood. 126: 2-2. DOI: 10.1182/Blood.V126.23.2.2 |
0.49 |
|
| 2014 |
Saadatpour A, Guo G, Orkin SH, Yuan GC. Characterizing heterogeneity in leukemic cells using single-cell gene expression analysis. Genome Biology. 15: 525. PMID 25517911 DOI: 10.1186/S13059-014-0525-9 |
0.41 |
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| 2014 |
Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen RS, Stehling-Sun S, Sabo PJ, Byron R, Humbert R, Thurman RE, Johnson AK, Vong S, Lee K, Bates D, ... ... Orkin SH, et al. Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science (New York, N.Y.). 346: 1007-12. PMID 25411453 DOI: 10.1126/Science.1246426 |
0.375 |
|
| 2014 |
Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, ... ... Orkin SH, et al. A comparative encyclopedia of DNA elements in the mouse genome. Nature. 515: 355-64. PMID 25409824 DOI: 10.1038/Nature13992 |
0.618 |
|
| 2014 |
Li Y, Esain V, Teng L, Xu J, Kwan W, Frost IM, Yzaguirre AD, Cai X, Cortes M, Maijenburg MW, Tober J, Dzierzak E, Orkin SH, Tan K, North TE, et al. Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production. Genes & Development. 28: 2597-612. PMID 25395663 DOI: 10.1101/Gad.253302.114 |
0.424 |
|
| 2014 |
Lundberg P, Takizawa H, Kubovcakova L, Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC. Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F. The Journal of Experimental Medicine. 211: 2213-30. PMID 25288396 DOI: 10.1084/Jem.20131371 |
0.462 |
|
| 2014 |
Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, ... ... Orkin SH, et al. TMEM14C is required for erythroid mitochondrial heme metabolism. The Journal of Clinical Investigation. 124: 4294-304. PMID 25157825 DOI: 10.1172/Jci76979 |
0.39 |
|
| 2014 |
Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. The Journal of Biological Chemistry. 289: 21312-24. PMID 24907273 DOI: 10.1074/Jbc.M114.564625 |
0.31 |
|
| 2014 |
Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 157: 549-64. PMID 24766805 DOI: 10.1016/J.Cell.2014.04.006 |
0.458 |
|
| 2014 |
Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H. Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. The Journal of Experimental Medicine. 211: 909-27. PMID 24711581 DOI: 10.1084/Jem.20131065 |
0.371 |
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| 2014 |
Yao H, Goldman DC, Nechiporuk T, Kawane S, McWeeney SK, Tyner JW, Fan G, Kerenyi MA, Orkin SH, Fleming WH, Mandel G. Corepressor Rcor1 is essential for murine erythropoiesis. Blood. 123: 3175-84. PMID 24652990 DOI: 10.1182/Blood-2013-11-538678 |
0.493 |
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| 2014 |
Pinello L, Xu J, Orkin SH, Yuan GC. Analysis of chromatin-state plasticity identifies cell-type-specific regulators of H3K27me3 patterns. Proceedings of the National Academy of Sciences of the United States of America. 111: E344-53. PMID 24395799 DOI: 10.1073/Pnas.1322570111 |
0.407 |
|
| 2014 |
Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, De Los Angeles A, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, ... ... Orkin SH, et al. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Molecular Cell. 53: 32-48. PMID 24361252 DOI: 10.1016/J.Molcel.2013.11.011 |
0.81 |
|
| 2014 |
Xie H, Xu J, Hsu JH, Nguyen M, Fujiwara Y, Peng C, Orkin SH. Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. Cell Stem Cell. 14: 68-80. PMID 24239285 DOI: 10.1016/J.Stem.2013.10.001 |
0.481 |
|
| 2014 |
Stankov MV, El Khatib M, Kumar Thakur B, Heitmann K, Panayotova-Dimitrova D, Schoening J, Bourquin JP, Schweitzer N, Leverkus M, Welte K, Reinhardt D, Li Z, Orkin SH, Behrens GM, Klusmann JH. Histone deacetylase inhibitors induce apoptosis in myeloid leukemia by suppressing autophagy. Leukemia. 28: 577-88. PMID 24080946 DOI: 10.1038/Leu.2013.264 |
0.396 |
|
| 2014 |
Xie H, Peng C, Qi J, Cheloni G, Das P, Huang J, Nguyen M, Li S, Bradner JE, Orkin SH. Eradication of Chronic Myelogenous Leukemia By Inactivation of the Polycomb Group Protein EZH2 Blood. 124: 778-778. DOI: 10.1182/Blood.V124.21.778.778 |
0.408 |
|
| 2014 |
Danis E, Yamauchi T, Echanique K, Haladyna J, Xie H, Zhu N, Riedel S, Bernt KM, Orkin SH, Armstrong SA, Neff T. Context Dependent Role of Polycomb Repressive Complex 2 in Acute Leukemia Blood. 124: 610-610. DOI: 10.1182/Blood.V124.21.610.610 |
0.459 |
|
| 2014 |
Li Y, Esain V, Teng L, Xu J, Frost I, Kwan W, Yzaguirre AD, Maijenberg MW, Orkin SH, Tan K, North TE, Speck NA. Inflammatory Signaling Regulates Embryonic Hematopoietic Stem and Lymphoid Progenitor Cell Formation Blood. 124: 2902-2902. DOI: 10.1182/Blood.V124.21.2902.2902 |
0.449 |
|
| 2014 |
Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, et al. Erythroid Cells Adapt to L-Leucine Scarcity By Reducing Hemoglobin Production Via the mTORC1/4E-BP Pathway Blood. 124: 2660-2660. DOI: 10.1182/Blood.V124.21.2660.2660 |
0.347 |
|
| 2014 |
Ghamari A, Jaensch E, Giadone R, Akie TE, Xu J, Bauer D, Orkin SH, Cantor AB. An SCF-FBXW7 Ubiquitin Ligase Mediated Feedback Loop Facilitates GATA Factor Switching and Reinforces Commitment to Terminal Erythroid Maturation Blood. 124: 245-245. DOI: 10.1182/Blood.V124.21.245.245 |
0.482 |
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| 2014 |
Xu J, Shao Z, Li D, Xie H, Kim W, Huang J, Pinello L, Glass K, Yuan G, Orkin SH. Developmental Control of Polycomb Subunit Composition Mediates a Switch to Non-Canonical Functions during Hematopoiesis Blood. 124: 241-241. DOI: 10.1182/Blood.V124.21.241.241 |
0.484 |
|
| 2014 |
Brendel C, Guda S, Renella R, Du P, Bauer DE, Canver MC, Kamran SC, Thornton J, de Boer H, Milsom MD, Orkin SH, Gregory R, Williams DA. Optimization of Bcl11a Knockdown By miRNA Scaffold Embedded Shrnas Leading to Enhanced Induction of Fetal Hemoglobin in Erythroid Cells for the Treatment of Beta-Hemoglobinopathies Blood. 124: 2150-2150. DOI: 10.1182/Blood.V124.21.2150.2150 |
0.421 |
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| 2014 |
Shimizu T, Hao-Shen H, Kubovcakova L, Lundberg P, Dirnhofer S, Orkin SH, Grisouard J, Shimizu Y, Pianta A, Szczerba B, Nienhold R, Skoda RC. JAK2V617F and Loss of Ezh2 in Hematopoietic Cells Contribute Synergistically to Myeloproliferative Neoplasm Initiation Potential, and Accelerate Progression of Disease Blood. 124: 158-158. DOI: 10.1182/Blood.V124.21.158.158 |
0.357 |
|
| 2014 |
Speck N, Li Y, Esain V, Teng L, Xu J, Phillips-Yzaguirre A, Maijenburg M, Dzierzak E, Orkin S, Tan K, North T. Inflammatory signaling regulates the number of lymphoid progenitors and HSCs in the embryo Experimental Hematology. 42: S5. DOI: 10.1016/J.Exphem.2014.07.018 |
0.308 |
|
| 2013 |
Elagib KE, Rubinstein JD, Delehanty LL, Ngoh VS, Greer PA, Li S, Lee JK, Li Z, Orkin SH, Mihaylov IS, Goldfarb AN. Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. Developmental Cell. 27: 607-20. PMID 24369834 DOI: 10.1016/J.Devcel.2013.11.013 |
0.339 |
|
| 2013 |
Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan GC, Porteus MH, ... ... Orkin SH, et al. An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Science (New York, N.Y.). 342: 253-7. PMID 24115442 DOI: 10.1126/Science.1242088 |
0.376 |
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| 2013 |
Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 13: 492-505. PMID 24035353 DOI: 10.1016/J.Stem.2013.07.017 |
0.764 |
|
| 2013 |
Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nature Chemical Biology. 9: 643-50. PMID 23974116 DOI: 10.1038/Nchembio.1331 |
0.416 |
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| 2013 |
Luc S, Orkin SH. Delineating the mixed lineage leukemia gene expression network in hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 11670-1. PMID 23824294 DOI: 10.1073/Pnas.1310349110 |
0.489 |
|
| 2013 |
Kerenyi MA, Shao Z, Hsu YJ, Guo G, Luc S, O'Brien K, Fujiwara Y, Peng C, Nguyen M, Orkin SH. Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2: e00633. PMID 23795291 DOI: 10.7554/Elife.00633 |
0.49 |
|
| 2013 |
Xu J, Bauer DE, Kerenyi MA, Vo TD, Hou S, Hsu YJ, Yao H, Trowbridge JJ, Mandel G, Orkin SH. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proceedings of the National Academy of Sciences of the United States of America. 110: 6518-23. PMID 23576758 DOI: 10.1073/Pnas.1303976110 |
0.472 |
|
| 2013 |
Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, et al. ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes & Development. 27: 683-98. PMID 23512661 DOI: 10.1101/Gad.211011.112 |
0.575 |
|
| 2013 |
Sankaran VG, Orkin SH. Genome-wide association studies of hematologic phenotypes: A window into human hematopoiesis Current Opinion in Genetics and Development. 23: 339-344. PMID 23477921 DOI: 10.1016/J.Gde.2013.02.006 |
0.543 |
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| 2013 |
Staber PB, Zhang P, Ye M, Welner RS, Nombela-Arrieta C, Bach C, Kerenyi M, Bartholdy BA, Zhang H, Alberich-Jordà M, Lee S, Yang H, Ng F, Zhang J, Leddin M, ... ... Orkin SH, et al. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Molecular Cell. 49: 934-46. PMID 23395001 DOI: 10.1016/J.Molcel.2013.01.007 |
0.478 |
|
| 2013 |
Sankaran VG, Orkin SH. The switch from fetal to adult hemoglobin Cold Spring Harbor Perspectives in Medicine. 3. PMID 23209159 DOI: 10.1101/Cshperspect.A011643 |
0.559 |
|
| 2013 |
Bai X, Trowbridge JJ, Riley E, Lee JA, DiBiase A, Kaartinen VM, Orkin SH, Zon LI. TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes. Developmental Biology. 373: 422-30. PMID 23159334 DOI: 10.1016/J.Ydbio.2012.10.008 |
0.584 |
|
| 2013 |
Kerenyi MA, Shao Z, Hsu Y, Guo G, Luc S, O'Brien K, Fujiwara Y, Peng C, Nguyen M, Orkin SH. Author response: Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation Elife. DOI: 10.7554/Elife.00633.024 |
0.414 |
|
| 2013 |
Orkin SH. Genetics and Epigenetics of Fetal Hemoglobin Control Blood. 122. DOI: 10.1182/Blood.V122.21.Sci-12.Sci-12 |
0.385 |
|
| 2013 |
Liddicoat B, Hartner J, Chalk A, Lu J, Orkin SH, Walkley CR. ADAR1 Is Essential For Erythroid Development Blood. 122: 9-9. DOI: 10.1182/Blood.V122.21.9.9 |
0.446 |
|
| 2013 |
Bauer DE, Kamran SC, Lessard S, Xu J, Fujiwara Y, Lin C, Shao Z, Canver MC, Smith EC, Pinello L, Sabo PJ, Vierstra J, Voit RA, Yuan G, Porteus MH, ... ... Orkin SH, et al. Fine-Mapping and Genome Editing Reveal An Essential Erythroid Enhancer At The HbF-Associated BCL11A Locus Blood. 122: 437-437. DOI: 10.1182/Blood.V122.21.437.437 |
0.423 |
|
| 2013 |
Bauer DE, Peng C, Smith EC, Orkin SH. Identification Of BCL11A Structure-Function Domains For Fetal Hemoglobin Silencing Blood. 122: 435-435. DOI: 10.1182/Blood.V122.21.435.435 |
0.468 |
|
| 2013 |
Perez-Ladaga A, Caughey B, Xie H, Orkin SH, Sykes DB, Ebert BL, Bejar R. Functional Defects In Neutrophils Derived From Ezh2 Null Mice Blood. 122: 1556-1556. DOI: 10.1182/Blood.V122.21.1556.1556 |
0.441 |
|
| 2013 |
Baena E, Shao Z, Linn D, Glass K, Hamblen M, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho F, Bronson RT, Mucci L, Loda M, Yuan G, Li Z, ... Orkin SH, et al. Abstract 5393: ETV1 directs androgen metabolism and confers aggressive prostate cancer in engineered mice and patients. Cancer Research. 73: 5393-5393. DOI: 10.1158/1538-7445.Am2013-5393 |
0.57 |
|
| 2013 |
Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Abstract B254: Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B254 |
0.403 |
|
| 2013 |
Duan D, Org T, Ferrari R, Montel-Hagen A, van Handel B, Sasidharan R, Fujiwara Y, Orkin S, Kurdistani S, Mikkola H. Scl represses cardiogenesis via distant enhancers during hemogenic endothelium specification Experimental Hematology. 41: S16. DOI: 10.1016/J.Exphem.2013.05.062 |
0.31 |
|
| 2012 |
Maclean GA, Menne TF, Guo G, Sanchez DJ, Park IH, Daley GQ, Orkin SH. Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 17567-72. PMID 23045682 DOI: 10.1182/Blood.V118.21.921.921 |
0.413 |
|
| 2012 |
Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HK, Yuan GC, Orkin SH. Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis. Developmental Cell. 23: 796-811. PMID 23041383 DOI: 10.1016/J.Devcel.2012.09.003 |
0.404 |
|
| 2012 |
Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes & Development. 26: 2075-87. PMID 22929040 DOI: 10.1101/Gad.197020.112 |
0.622 |
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| 2012 |
Bauer DE, Kamran SC, Orkin SH. Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders. Blood. 120: 2945-53. PMID 22904296 DOI: 10.1182/Blood-2012-06-292078 |
0.432 |
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| 2012 |
Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, et al. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 150: 590-605. PMID 22863011 DOI: 10.1016/J.Cell.2012.06.026 |
0.467 |
|
| 2012 |
Funnell AP, Norton LJ, Mak KS, Burdach J, Artuz CM, Twine NA, Wilkins MR, Power CA, Hung TT, Perdomo J, Koh P, Bell-Anderson KS, Orkin SH, Fraser ST, Perkins AC, et al. The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo. Molecular and Cellular Biology. 32: 3281-92. PMID 22711990 DOI: 10.1128/Mcb.00173-12 |
0.497 |
|
| 2012 |
Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. The Journal of Clinical Investigation. 122: 2439-43. PMID 22706301 DOI: 10.1172/Jci63597 |
0.591 |
|
| 2012 |
Shao Z, Zhang Y, Yuan GC, Orkin SH, Waxman DJ. MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets. Genome Biology. 13: R16. PMID 22424423 DOI: 10.1186/Gb-2012-13-3-R16 |
0.411 |
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| 2012 |
Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proceedings of the National Academy of Sciences of the United States of America. 109: 5028-33. PMID 22396593 DOI: 10.1073/Pnas.1202258109 |
0.423 |
|
| 2012 |
Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes & Development. 26: 344-9. PMID 22345515 DOI: 10.1101/gad.184341.111 |
0.417 |
|
| 2012 |
Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, ... ... Orkin SH, et al. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Science Translational Medicine. 4: 121ra18. PMID 22344686 DOI: 10.1126/Scitranslmed.3003205 |
0.626 |
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| 2012 |
Shi Y, Kirwan P, Smith J, MacLean G, Orkin SH, Livesey FJ. A human stem cell model of early Alzheimer's disease pathology in Down syndrome. Science Translational Medicine. 4: 124ra29. PMID 22344463 DOI: 10.1126/Scitranslmed.3003771 |
0.322 |
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| 2012 |
Chan KS, Xu J, Wardan H, McColl B, Orkin S, Vadolas J. Generation of a genomic reporter assay system for analysis of γ- and β-globin gene regulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1736-44. PMID 22267339 DOI: 10.1096/Fj.11-199356 |
0.412 |
|
| 2012 |
He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes & Development. 26: 37-42. PMID 22215809 DOI: 10.1101/Gad.173930.111 |
0.377 |
|
| 2012 |
Trowbridge JJ, Orkin SH. Dnmt3a silences hematopoietic stem cell self-renewal. Nature Genetics. 44: 13-4. PMID 22200773 DOI: 10.1038/Ng.1043 |
0.428 |
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| 2012 |
He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, et al. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circulation Research. 110: 406-15. PMID 22158708 DOI: 10.1161/Circresaha.111.252205 |
0.536 |
|
| 2012 |
Basu-Roy U, Seo E, Ramanathapuram L, Rapp TB, Perry JA, Orkin SH, Mansukhani A, Basilico C. Sox2 maintains self renewal of tumor-initiating cells in osteosarcomas. Oncogene. 31: 2270-82. PMID 21927024 DOI: 10.1038/Onc.2011.405 |
0.43 |
|
| 2012 |
Bauer DE, Kamran SC, Xu J, Lin C, Shao Z, Fujiwara Y, Voit RA, Porteus MH, Stamatoyannopoulos JA, Orkin SH. HbF-Associated Genetic Variation Marks an Erythroid Regulatory Element Essential for BCL11A Transcription and Subsequent Stage-Specific Globin Expression Blood. 120: 828-828. DOI: 10.1182/Blood.V120.21.828.828 |
0.449 |
|
| 2012 |
Renella R, Perlov A, Harris CE, Bauer DE, Xu J, Guda S, Milsom MD, Orkin SH, Williams DA. Hematopoietic SIN Lentiviral Micro RNA-Mediated Silencing of BCL11A: Pre-Clinical Evidence for a Sickle Cell Disease Gene-Therapy Trial Blood. 120: 753-753. DOI: 10.1182/Blood.V120.21.753.753 |
0.44 |
|
| 2012 |
Org T, Duan D, Montel-Hagen A, Ferrari R, Van Handel B, Sasidharan R, Orkin SH, Kurdistani S, Mikkola H. Scl/Tal1 Directly Activates Hematopoiesis and Represses Cardiogenesis During Mesodermal Diversification Blood. 120: 3446-3446. DOI: 10.1182/Blood.V120.21.3446.3446 |
0.482 |
|
| 2012 |
Trowbridge JJ, Li M, Roberts CWM, Orkin SH. Genetic or Pharmacological Reductions in DNA Methylation Selectively Inhibit Peripheral T-Cell Lymphomagenesis. Blood. 120: 2760-2760. DOI: 10.1182/Blood.V120.21.2760.2760 |
0.317 |
|
| 2012 |
Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HKA, Yuan G, Orkin SH. Genomic Determinants of Human Fetal and Adult Erythroid Gene Expression Blood. 120: 1227-1227. DOI: 10.1182/Blood.V120.21.1227.1227 |
0.474 |
|
| 2012 |
Dou DR, Minasian A, Sierra MI, Saarikoski P, Xu J, Orkin SH, Prashad SL, Magnusson M, Zack JA, Crooks GM, Galic Z, Mikkola HKA. Inability to Express HOXA Cluster and BCL11A Genes Compromises Self-Renewal and Multipotency of hESC-Derived Hematopoietic Cells Blood. 120: 1190-1190. DOI: 10.1182/Blood.V120.21.1190.1190 |
0.435 |
|
| 2012 |
Koch ML, Zhang X, Hamblen M, Godinho F, Reinhardt D, Klusmann J, Orkin SH, Li Z. Reduced Erg Dosage Perturbs Fetal and Adult Hematopoiesis Blood. 120: 1189-1189. DOI: 10.1182/Blood.V120.21.1189.1189 |
0.482 |
|
| 2012 |
Perry JA, Orkin S. Abstract 4234: A genome-wide RNAi screen implicates histone deacetylases as a therapeutic target for osteosarcoma Cancer Research. 72: 4234-4234. DOI: 10.1158/1538-7445.Am2012-4234 |
0.355 |
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| 2012 |
Baena E, Shao Z, Linn D, Hamblen M, Glass K, Saumyadipta P, Fujiwara Y, Godinho F, Kim J, Al-Shhrour F, Nguyen M, Yuan G, Bronson RT, Loda M, Orkin SH, et al. Abstract 2965: ERG and ETV1 regulate a common transcriptional network in prostate cells but in an opposite fashion Cancer Research. 72: 2965-2965. DOI: 10.1158/1538-7445.Am2012-2965 |
0.577 |
|
| 2011 |
Kim J, Orkin SH. Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine. Genome Medicine. 3: 75. PMID 22126538 DOI: 10.1186/Gm291 |
0.656 |
|
| 2011 |
Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science (New York, N.Y.). 334: 993-6. PMID 21998251 DOI: 10.1126/Science.1211053 |
0.603 |
|
| 2011 |
Fidalgo M, Shekar PC, Ang YS, Fujiwara Y, Orkin SH, Wang J. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells (Dayton, Ohio). 29: 1705-16. PMID 21915945 DOI: 10.1002/Stem.736 |
0.516 |
|
| 2011 |
Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. A functional element necessary for fetal hemoglobin silencing. The New England Journal of Medicine. 365: 807-14. PMID 21879898 DOI: 10.1056/Nejmoa1103070 |
0.597 |
|
| 2011 |
Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, ... ... Orkin SH, et al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proceedings of the National Academy of Sciences of the United States of America. 108: 13379-86. PMID 21788502 DOI: 10.1073/Pnas.1110104108 |
0.307 |
|
| 2011 |
Orkin SH, Hochedlinger K. Chromatin connections to pluripotency and cellular reprogramming. Cell. 145: 835-50. PMID 21663790 DOI: 10.1016/J.Cell.2011.05.019 |
0.436 |
|
| 2011 |
Orkin SH. Genome Medicine: stem cells, genomics and translational research. Genome Medicine. 3: 34. PMID 21658298 DOI: 10.1186/Gm250 |
0.453 |
|
| 2011 |
Xu J, Orkin SH. The erythroid/myeloid lineage fate paradigm takes a new player. The Embo Journal. 30: 983-5. PMID 21407249 DOI: 10.1038/Emboj.2011.45 |
0.375 |
|
| 2011 |
Snow JW, Trowbridge JJ, Johnson KD, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. Context-dependent function of "GATA switch" sites in vivo. Blood. 117: 4769-72. PMID 21398579 DOI: 10.1182/Blood-2010-10-313031 |
0.436 |
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| 2011 |
Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 8: 200-13. PMID 21295276 DOI: 10.1016/J.Stem.2011.01.008 |
0.468 |
|
| 2011 |
Sankaran VG, Menne TF, Šćepanović D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proceedings of the National Academy of Sciences of the United States of America. 108: 1519-24. PMID 21205891 DOI: 10.1073/Pnas.1018384108 |
0.606 |
|
| 2011 |
Bauer DE, Orkin SH. Update on fetal hemoglobin gene regulation in hemoglobinopathies. Current Opinion in Pediatrics. 23: 1-8. PMID 21157349 DOI: 10.1097/Mop.0B013E3283420Fd0 |
0.348 |
|
| 2011 |
Wilber A, Hargrove PW, Kim YS, Riberdy JM, Sankaran VG, Papanikolaou E, Georgomanoli M, Anagnou NP, Orkin SH, Nienhuis AW, Persons DA. Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood. 117: 2817-26. PMID 21156846 DOI: 10.1182/Blood-2010-08-300723 |
0.606 |
|
| 2011 |
Elagib K, Rubinstein JD, Delehanty LL, Greer PA, Li S, Lee JK, Mihaylov IS, Li Z, Orkin SH, Goldfarb A. Calpain Drives Megakaryopoiesis by Targeting the 7SK snRNP Complex: A Connection to Down Syndrome Megakaryocytic Neoplasia Blood. 118: 552-552. DOI: 10.1182/Blood.V118.21.552.552 |
0.396 |
|
| 2011 |
Kerenyi MA, Hsu J, Shao Z, Orkin SH. Histone Demethylase LSD1 Is Required to Repress Hematopoietic Stem Cell Signatures in Mature Blood Cells to Permit Terminal Differentiation Blood. 118: 550-550. DOI: 10.1182/Blood.V118.21.550.550 |
0.525 |
|
| 2011 |
Stankov MV, Heitmann K, Li Z, Thakur BK, Panayotova-Dimitrova D, Schöning J, Bourquin J, Dittrich T, Emmrich S, Schweitzer N, Leverkus M, Reinhardt D, Orkin SH, Behrens GMN, Klusmann J. mTOR Pathway Links Suppressed Autophagy to HDAC Inhibitor-Induced Apoptosis in Myeloid Leukemia, Blood. 118: 3614-3614. DOI: 10.1182/Blood.V118.21.3614.3614 |
0.344 |
|
| 2011 |
Esrick EB, Xu J, Lin K, McConkey ME, Frisbee A, Poveromo L, Orkin SH, Bradner JE, Ebert BL. Induction of Fetal Hemoglobin by Inactivation of HDAC1 or HDAC2 without Altering Cellular Proliferation Blood. 118: 354-354. DOI: 10.1182/Blood.V118.21.354.354 |
0.355 |
|
| 2011 |
Xu J, Peng C, Sankaran VG, Orkin SH. Correction of Murine Sickle Cell Disease Through Interference with Fetal Hemoglobin Silencing Blood. 118: 351-351. DOI: 10.1182/Blood.V118.21.351.351 |
0.586 |
|
| 2011 |
Montel-Hagen A, Handel BV, Ferrari R, Sasidharan R, Org T, Boogerd K, Nakano H, Zhou J, Li X, Pellegrini M, Orkin SH, Nakano A, Kurdistani S, Evans S, Mikkola H. Latent Cardiogenic Potential in Endocardium and Hemogenic Endothelium Revealed in the Absence of Scl/tal1 Blood. 118: 2362-2362. DOI: 10.1182/Blood.V118.21.2362.2362 |
0.412 |
|
| 2011 |
Bauer DE, Xu J, Fujiwara Y, Stamatoyannopoulos JA, Orkin SH. Functional Evaluation of HbF-Associated Region of BCL11A Locus Blood. 118: 2148-2148. DOI: 10.1182/Blood.V118.21.2148.2148 |
0.395 |
|
| 2011 |
Lu T, Fabry V, Lim E, Cole E, Orkin S, Rothenberg M. MicroRNA-21 Deficiency Leads to an Attenuated Asthma Response in Mice Journal of Allergy and Clinical Immunology. 127: AB220-AB220. DOI: 10.1016/J.Jaci.2010.12.877 |
0.326 |
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| 2010 |
Bjork BC, Fujiwara Y, Davis SW, Qiu H, Saunders TL, Sandy P, Orkin S, Camper SA, Beier DR. A transient transgenic RNAi strategy for rapid characterization of gene function during embryonic development. Plos One. 5: e14375. PMID 21179568 DOI: 10.1371/Journal.Pone.0014375 |
0.621 |
|
| 2010 |
Galarneau G, Palmer CD, Sankaran VG, Orkin SH, Hirschhorn JN, Lettre G. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation Nature Genetics. 42: 1049-1051. PMID 21057501 DOI: 10.1038/Ng.707 |
0.541 |
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| 2010 |
Sankaran VG, Lettre G, Orkin SH, Hirschhorn JN. Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Annals of the New York Academy of Sciences. 1214: 47-56. PMID 21039591 DOI: 10.1111/J.1749-6632.2010.05821.X |
0.551 |
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| 2010 |
Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW. Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell. 18: 316-28. PMID 20951942 DOI: 10.1016/J.Ccr.2010.09.006 |
0.404 |
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| 2010 |
Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell. 143: 313-24. PMID 20946988 DOI: 10.1016/J.Cell.2010.09.010 |
0.633 |
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| 2010 |
Snow JW, Trowbridge JJ, Fujiwara T, Emambokus NE, Grass JA, Orkin SH, Bresnick EH. A single cis element maintains repression of the key developmental regulator Gata2. Plos Genetics. 6: e1001103. PMID 20838598 DOI: 10.1371/Journal.Pgen.1001103 |
0.412 |
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| 2010 |
Rao S, Zhen S, Roumiantsev S, McDonald LT, Yuan GC, Orkin SH. Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. Molecular and Cellular Biology. 30: 5364-80. PMID 20837710 DOI: 10.1128/Mcb.00419-10 |
0.474 |
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| 2010 |
Sankaran VG, Xu J, Orkin SH. Transcriptional silencing of fetal hemoglobin by BCL11A. Annals of the New York Academy of Sciences. 1202: 64-8. PMID 20712774 DOI: 10.1111/J.1749-6632.2010.05574.X |
0.628 |
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| 2010 |
Klusmann JH, Godinho FJ, Heitmann K, Maroz A, Koch ML, Reinhardt D, Orkin SH, Li Z. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes & Development. 24: 1659-72. PMID 20679399 DOI: 10.1101/Gad.1903410 |
0.396 |
|
| 2010 |
Orkin SH, Higgs DR. Medicine. Sickle cell disease at 100 years. Science (New York, N.Y.). 329: 291-2. PMID 20647458 DOI: 10.1126/Science.1194035 |
0.311 |
|
| 2010 |
Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, ... ... Orkin SH, et al. Epigenetic memory in induced pluripotent stem cells. Nature. 467: 285-90. PMID 20644535 DOI: 10.1038/Nature09342 |
0.435 |
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| 2010 |
Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, et al. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 142: 133-43. PMID 20603019 DOI: 10.1016/J.Cell.2010.05.028 |
0.707 |
|
| 2010 |
Snow JW, Kim J, Currie CR, Xu J, Orkin SH. Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP). The Journal of Biological Chemistry. 285: 28064-75. PMID 20587419 DOI: 10.1074/Jbc.M109.096909 |
0.627 |
|
| 2010 |
Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes & Development. 24: 783-98. PMID 20395365 DOI: 10.1101/Gad.1897310 |
0.609 |
|
| 2010 |
Trowbridge JJ, Orkin SH. DNA methylation in adult stem cells: new insights into self-renewal. Epigenetics : Official Journal of the Dna Methylation Society. 5: 189-93. PMID 20364115 DOI: 10.4161/Epi.5.3.11374 |
0.373 |
|
| 2010 |
Sankaran VG, Xu J, Orkin SH. Advances in the understanding of haemoglobin switching. British Journal of Haematology. 149: 181-94. PMID 20201948 DOI: 10.1111/J.1365-2141.2010.08105.X |
0.573 |
|
| 2010 |
Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 115: 2928-37. PMID 20154221 DOI: 10.1182/Blood-2009-06-227629 |
0.301 |
|
| 2010 |
Kim J, Orkin SH. Systematic tracking of cell fate changes. Nature Biotechnology. 28: 146-7. PMID 20139953 DOI: 10.1038/Nbt0210-146 |
0.612 |
|
| 2010 |
Orkin SH. New Strategies to Define Regulators of Fetal Hemoglobin Blood. 116. DOI: 10.1182/Blood.V116.21.Sci-17.Sci-17 |
0.443 |
|
| 2010 |
Bai X, Trowbridge J, Lee J, Orkin SH, Zon LI. Analysis of TIF1gamma Conditional Knockout Establishes a Requirement for the Differentiation of Multiple Hematopoietic Lineages Blood. 116: 744-744. DOI: 10.1182/Blood.V116.21.744.744 |
0.607 |
|
| 2010 |
Xu J, Sankaran VG, Esrick EB, Ebert BL, Orkin SH. Reactivation of Silenced Human HbF In Adult Mice by Inactivation of BCL11A Blood. 116: 643-643. DOI: 10.1182/Blood.V116.21.643.643 |
0.604 |
|
| 2010 |
Heitmann K, Li Z, Klusmann J, Thakur BK, Schöning J, Bourquin J, Orkin SH, Reinhardt D. Gene Expression-Based Chemical Genomics Identifies Valproic Acid to Revert the Oncogenic Effect of GATA1s In Down Syndrome Megakaryoblastic Leukemia. Blood. 116: 3646-3646. DOI: 10.1182/Blood.V116.21.3646.3646 |
0.465 |
|
| 2010 |
Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho Y, Koelhoffer EC, Pomeroy SL, Orkin SH, Roberts CWM. Abstract LB-237: Epigenetic antagonism between Polycomb and SWI/SNF complexes duringoncogenic transformation Cancer Research. 71: 4799-4799. DOI: 10.1158/1538-7445.Am2011-Lb-237 |
0.335 |
|
| 2010 |
Rao S, Roumiantsev S, McDonald L, Orkin SH. The Role Of Sall4 In Embryonic Stem Cell Pluripotency Biology of Blood and Marrow Transplantation. 16. DOI: 10.1016/J.Bbmt.2009.12.111 |
0.402 |
|
| 2009 |
Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 139: 1303-14. PMID 20064376 DOI: 10.1016/J.Cell.2009.12.003 |
0.433 |
|
| 2009 |
Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB. Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Molecular Cell. 36: 682-95. PMID 19941827 DOI: 10.1016/J.Molcel.2009.11.002 |
0.443 |
|
| 2009 |
Trowbridge JJ, Snow JW, Kim J, Orkin SH. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell. 5: 442-9. PMID 19796624 DOI: 10.1182/Blood.V114.22.392.392 |
0.63 |
|
| 2009 |
Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Developmental and species-divergent globin switching are driven by BCL11A. Nature. 460: 1093-7. PMID 19657335 DOI: 10.1038/Nature08243 |
0.618 |
|
| 2009 |
Snow JW, Orkin SH. Translational isoforms of FOG1 regulate GATA1-interacting complexes. The Journal of Biological Chemistry. 284: 29310-9. PMID 19654328 DOI: 10.1074/Jbc.M109.043497 |
0.354 |
|
| 2009 |
Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Molecular and Cellular Biology. 29: 5168-80. PMID 19620289 DOI: 10.1128/Mcb.00482-09 |
0.677 |
|
| 2009 |
Schindler JW, Van Buren D, Foudi A, Krejci O, Qin J, Orkin SH, Hock H. TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 5: 43-53. PMID 19570513 DOI: 10.1016/J.Stem.2009.04.019 |
0.447 |
|
| 2009 |
Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJ. A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal Genes and Development. 23: 837-848. PMID 19339689 DOI: 10.1101/Gad.1769609 |
0.661 |
|
| 2009 |
Kim J, Cantor AB, Orkin SH, Wang J. Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nature Protocols. 4: 506-17. PMID 19325547 DOI: 10.1038/Nprot.2009.23 |
0.609 |
|
| 2009 |
Wang J, Cantor AB, Orkin SH. Tandem affinity purification of protein complexes in mouse embryonic stem cells using in vivo biotinylation. Current Protocols in Stem Cell Biology. Unit1B.5. PMID 19306258 DOI: 10.1002/9780470151808.Sc01B05S8 |
0.402 |
|
| 2009 |
Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 113: 3461-71. PMID 19211936 DOI: 10.1182/Blood-2008-07-167577 |
0.483 |
|
| 2009 |
Shen X, Orkin SH. Glimpses of the epigenetic landscape. Cell Stem Cell. 4: 1-2. PMID 19128786 DOI: 10.1016/J.Stem.2008.12.006 |
0.378 |
|
| 2009 |
Xu J, Sankaran VG, Fujiwara Y, Orkin SH. Control of Hemoglobin Switching by BCL11A. Blood. 114: 5-5. DOI: 10.1182/Blood.V114.22.5.5 |
0.63 |
|
| 2009 |
Klusmann J, Godinho F, Heitmann K, Maroz A, Reinhardt D, Orkin SH, Li Z. Developmental Stage-Specific Interplay Between GATA1 and IGF Signaling in Fetal Hematopoiesis and Leukemogenesis. Blood. 114: 386-386. DOI: 10.1182/Blood.V114.22.386.386 |
0.435 |
|
| 2009 |
Heitmann K, Thakur B, Li Z, Schöning J, Bourquin J, Reinhardt D, Orkin S, Klusmann J. Gene expression-based chemical genomics identifies VPA to revert the oncogenic effect of GATA1s in Down syndrome leukemia Klinische Padiatrie. 221. DOI: 10.1055/S-0029-1222645 |
0.327 |
|
| 2009 |
Fujiwara Y, Orkin SH. Molecular regulation of the state of embryonic stem cells Stem Cells and Cancer. 33-60. DOI: 10.1007/978-0-387-89611-3_2 |
0.317 |
|
| 2008 |
Wang J, Trowbridge JJ, Rao S, Orkin SH. Proteomic studies of stem cells Stembook. PMID 20614589 DOI: 10.3824/Stembook.1.4.1 |
0.417 |
|
| 2008 |
Orkin SH, Wang J, Kim J, Chu J, Rao S, Theunissen TW, Shen X, Levasseur DN. The transcriptional network controlling pluripotency in ES cells Cold Spring Harbor Symposia On Quantitative Biology. 73: 195-202. PMID 19478325 DOI: 10.1101/Sqb.2008.72.001 |
0.662 |
|
| 2008 |
Hartner JC, Walkley CR, Lu J, Orkin SH. ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nature Immunology. 10: 109-15. PMID 19060901 DOI: 10.1038/Ni.1680 |
0.472 |
|
| 2008 |
Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (New York, N.Y.). 322: 1839-42. PMID 19056937 DOI: 10.1126/science.1165409 |
0.637 |
|
| 2008 |
Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Molecular Cell. 32: 491-502. PMID 19026780 DOI: 10.1016/J.Molcel.2008.10.016 |
0.641 |
|
| 2008 |
Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH, Peters AH. Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Developmental Cell. 15: 668-79. PMID 18848501 DOI: 10.1016/J.Devcel.2008.08.015 |
0.342 |
|
| 2008 |
Walkley CR, Sankaran VG, Orkin SH. Rb and hematopoiesis: stem cells to anemia. Cell Division. 3: 13. PMID 18775080 DOI: 10.1186/1747-1028-3-13 |
0.667 |
|
| 2008 |
Beuling E, Bosse T, aan de Kerk DJ, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Developmental Biology. 322: 179-89. PMID 18692040 DOI: 10.1016/J.Ydbio.2008.07.022 |
0.445 |
|
| 2008 |
Lettre G, Sankaran VG, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 11869-74. PMID 18667698 DOI: 10.1073/Pnas.0804799105 |
0.53 |
|
| 2008 |
Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes & Development. 22: 1662-76. PMID 18559481 DOI: 10.1101/Gad.1656808 |
0.583 |
|
| 2008 |
Wang J, Levasseur DN, Orkin SH. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proceedings of the National Academy of Sciences of the United States of America. 105: 6326-31. PMID 18436640 DOI: 10.1073/Pnas.0802288105 |
0.461 |
|
| 2008 |
Sue N, Jack BH, Eaton SA, Pearson RC, Funnell AP, Turner J, Czolij R, Denyer G, Bao S, Molero-Navajas JC, Perkins A, Fujiwara Y, Orkin SH, Bell-Anderson K, Crossley M. Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis. Molecular and Cellular Biology. 28: 3967-78. PMID 18391014 DOI: 10.1128/Mcb.01942-07 |
0.436 |
|
| 2008 |
Rhodes KE, Gekas C, Wang Y, Lux CT, Francis CS, Chan DN, Conway S, Orkin SH, Yoder MC, Mikkola HK. The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell. 2: 252-63. PMID 18371450 DOI: 10.1016/J.Stem.2008.01.001 |
0.408 |
|
| 2008 |
Kim J, Chu J, Shen X, Wang J, Orkin SH. An extended transcriptional network for pluripotency of embryonic stem cells. Cell. 132: 1049-61. PMID 18358816 DOI: 10.1016/J.Cell.2008.02.039 |
0.65 |
|
| 2008 |
Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, Lohuizen Mv, Peters AHFM. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos Nature Genetics. 40: 411-420. PMID 18311137 DOI: 10.1038/Ng.99 |
0.337 |
|
| 2008 |
Cantor AB, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH. Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. The Journal of Experimental Medicine. 205: 611-24. PMID 18299398 DOI: 10.1084/Jem.20070544 |
0.503 |
|
| 2008 |
Orkin SH, Zon LI. SnapShot: Hematopoiesis Cell. 132. PMID 18295585 DOI: 10.1016/j.cell.2008.02.013 |
0.417 |
|
| 2008 |
Orkin SH, Zon LI. Hematopoiesis: An Evolving Paradigm for Stem Cell Biology Cell. 132: 631-644. PMID 18295580 DOI: 10.1016/J.Cell.2008.01.025 |
0.576 |
|
| 2008 |
Levasseur DN, Wang J, Dorschner MO, Stamatoyannopoulos JA, Orkin SH. Oct4 dependence of chromatin structure within the extended Nanog locus in ES cells. Genes & Development. 22: 575-80. PMID 18283123 DOI: 10.1101/Gad.1606308 |
0.485 |
|
| 2008 |
Sankaran VG, Orkin SH, Walkley CR. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes & Development. 22: 463-75. PMID 18258751 DOI: 10.1182/Blood.V110.11.638.638 |
0.61 |
|
| 2008 |
Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, ... ... Orkin SH, et al. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 105: 1620-5. PMID 18245381 DOI: 10.1073/Pnas.0711566105 |
0.57 |
|
| 2008 |
Wang J, Orkin SH. A protein roadmap to pluripotency and faithful reprogramming Cells Tissues Organs. 188: 23-30. PMID 18196921 DOI: 10.1159/000113532 |
0.447 |
|
| 2008 |
Klusmann J, Godinho F, Pushpanathan T, Reinhardt D, Orkin SH, Li Z. GATA1s Mutant Protein Contributes to “Down” Syndrome Megakaryoblastic Leukemia by Derepression of E2F Targets. Blood. 112: 2248-2248. DOI: 10.1182/Blood.V112.11.2248.2248 |
0.46 |
|
| 2008 |
Kim J, Chu J, Shen X, Wang J, Orkin SH. An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells (DOI:10.1016/j.cell.2008.02.039) Cell. 133. DOI: 10.1016/J.Cell.2008.06.004 |
0.638 |
|
| 2007 |
Orkin SH, Pera M. Stem cells down under-ISSCR 2007 Cell Stem Cell. 1: 271-276. PMID 18399027 DOI: 10.1016/J.Stem.2007.08.007 |
0.369 |
|
| 2007 |
Wang J, Theunissen TW, Orkin SH. Site-directed, virus-free, and inducible RNAi in embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America. 104: 20850-20855. PMID 18093939 DOI: 10.1073/Pnas.0710565105 |
0.351 |
|
| 2007 |
Xie H, Orkin SH. Immunology: Changed destiny Nature. 449: 410-411. PMID 17898754 DOI: 10.1038/449410A |
0.436 |
|
| 2007 |
Saleque S, Kim J, Rooke HM, Orkin SH. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Molecular Cell. 27: 562-72. PMID 17707228 DOI: 10.1016/J.Molcel.2007.06.039 |
0.626 |
|
| 2007 |
North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447: 1007-11. PMID 17581586 DOI: 10.1038/Nature05883 |
0.571 |
|
| 2007 |
Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH. Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment Cell. 129: 1081-1095. PMID 17574022 DOI: 10.1016/J.Cell.2007.03.055 |
0.438 |
|
| 2007 |
Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR. Gata4 is necessary for normal pulmonary lobar development. American Journal of Respiratory Cell and Molecular Biology. 36: 391-7. PMID 17142311 DOI: 10.1165/Rcmb.2006-0211Rc |
0.554 |
|
| 2007 |
Klusmann J, Janikova K, Li Z, Orkin SH, Reinhardt D. Chromosome 21-Encoded miR-125b and Its Role in the Development of Myeloid Leukemia in Children with Down’s Syndrome. Blood. 110: 716-716. DOI: 10.1182/Blood.V110.11.716.716 |
0.312 |
|
| 2007 |
Rhodes KE, Gekas C, Wang Y, Lux CT, Francis CS, Conway S, Orkin SH, Yoder MC, Mikkola HK. Hematopoietic Stem Cells Emerge in the Placental Vasculature in the Absence of Circulation. Blood. 110: 1258-1258. DOI: 10.1182/Blood.V110.11.1258.1258 |
0.394 |
|
| 2007 |
Wang J, Rao S, Chu J, Shen X, Levasseur D, Theunissen T, Orkin S. Protein interaction network for pluripotency of ES cells: Possible clues to organization of self-renewal machinery in other stem cells Blood Cells, Molecules, and Diseases. 38: 164. DOI: 10.1016/J.Bcmd.2006.10.103 |
0.379 |
|
| 2006 |
Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 127: 1137-50. PMID 17123591 DOI: 10.1016/J.Cell.2006.10.028 |
0.419 |
|
| 2006 |
Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH. A protein interaction network for pluripotency of embryonic stem cells. Nature. 444: 364-8. PMID 17093407 DOI: 10.1038/Nature05284 |
0.442 |
|
| 2006 |
Ghinassi B, Sanchez M, Martelli F, Amabile G, Vannucchi AM, Migliaccio G, Orkin SH, Migliaccio AR. The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood. 109: 1460-71. PMID 17038527 DOI: 10.1182/Blood-2006-07-030726 |
0.451 |
|
| 2006 |
Mikkola HK, Orkin SH. The journey of developing hematopoietic stem cells. Development (Cambridge, England). 133: 3733-44. PMID 16968814 DOI: 10.1242/Dev.02568 |
0.402 |
|
| 2006 |
Rao S, Orkin SH. Unraveling the transcriptional network controlling ES cell pluripotency Genome Biology. 7. PMID 16942632 DOI: 10.1186/Gb-2006-7-8-230 |
0.442 |
|
| 2006 |
Walkley CR, Orkin SH. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells Proceedings of the National Academy of Sciences of the United States of America. 103: 9057-9062. PMID 16754850 DOI: 10.1073/Pnas.0603389103 |
0.45 |
|
| 2006 |
Pooter RFd, Schmitt TM, Pompa JLdl, Fujiwara Y, Orkin SH, Zúñiga-Pflücker JC. Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors Journal of Immunology. 176: 5267-5275. PMID 16621992 DOI: 10.4049/Jimmunol.176.9.5267 |
0.431 |
|
| 2006 |
Guyot B, Murai K, Fujiwara Y, Valverde-Garduno V, Hammett M, Wells S, Dear N, Orkin SH, Porcher C, Vyas P. Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1. Journal of Biological Chemistry. 281: 13733-13742. PMID 16551635 DOI: 10.1074/Jbc.M602052200 |
0.451 |
|
| 2006 |
Bourquin JP, Subramanian A, Langebrake C, Reinhardt D, Bernard O, Ballerini P, Baruchel A, Cavé H, Dastugue N, Hasle H, Kaspers GL, Lessard M, Michaux L, Vyas P, van Wering E, ... ... Orkin SH, et al. Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling. Proceedings of the National Academy of Sciences of the United States of America. 103: 3339-44. PMID 16492768 DOI: 10.1073/Pnas.0511150103 |
0.406 |
|
| 2006 |
Rooke HM, Orkin SH. Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo Blood. 107: 3527-3530. PMID 16391009 DOI: 10.1182/Blood-2005-10-4309 |
0.345 |
|
| 2006 |
Hock H, Orkin SH. Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Current Opinion in Hematology. 13: 1-6. PMID 16319680 DOI: 10.1097/01.Moh.0000190111.85284.8F |
0.48 |
|
| 2006 |
North TE, Goessling W, Kopani KR, Lengerke C, Walkley CR, Lord AM, Jang I, Grosser T, FitzGerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 Is a Potent Regulator of Vertebrate Hematopoietic Stem Cell Homeostasis. Blood. 108: 680-680. DOI: 10.1182/Blood.V108.11.680.680 |
0.573 |
|
| 2005 |
Muroyama Y, Fujiwara Y, Orkin SH, Rowitch DH. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube Nature. 438: 360-363. PMID 16292311 DOI: 10.1038/Nature04139 |
0.424 |
|
| 2005 |
Orkin SH. Chipping away at the embryonic stem cell network Cell. 122: 828-830. PMID 16179251 DOI: 10.1016/J.Cell.2005.09.002 |
0.462 |
|
| 2005 |
Mikkola HK, Gekas C, Orkin SH, Dieterlen-Lievre F. Placenta as a site for hematopoietic stem cell development. Experimental Hematology. 33: 1048-54. PMID 16140153 DOI: 10.1016/J.Exphem.2005.06.011 |
0.417 |
|
| 2005 |
Kadri Z, Maouche-Chretien L, Rooke HM, Orkin SH, Romeo PH, Mayeux P, Leboulch P, Chretien S. Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation Molecular and Cellular Biology. 25: 7412-7422. PMID 16107690 DOI: 10.1128/Mcb.25.17.7412-7422.2005 |
0.475 |
|
| 2005 |
Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes. Embo Reports. 6: 879-84. PMID 16082385 DOI: 10.1038/Sj.Embor.7400490 |
0.713 |
|
| 2005 |
Hock H, Orkin SH. Stem cells: the road not taken. Nature. 435: 573-5. PMID 15931202 DOI: 10.1038/435573A |
0.369 |
|
| 2005 |
Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nature Genetics. 37: 613-9. PMID 15895080 DOI: 10.1038/Ng1566 |
0.624 |
|
| 2005 |
Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh CA. Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science (New York, N.Y.). 308: 1794-8. PMID 15894532 DOI: 10.1126/Science.1110324 |
0.326 |
|
| 2005 |
Rodrigues NP, Janzen V, Forkert R, Dombkowski DM, Boyd AS, Orkin SH, Enver T, Vyas P, Scadden DT. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis Blood. 106: 477-484. PMID 15811962 DOI: 10.1182/Blood-2004-08-2989 |
0.468 |
|
| 2005 |
Gekas C, Dieterlen-Lièvre F, Orkin SH, Mikkola HK. The placenta is a niche for hematopoietic stem cells. Developmental Cell. 8: 365-75. PMID 15737932 DOI: 10.1016/J.Devcel.2004.12.016 |
0.372 |
|
| 2005 |
Schlaeger TM, Mikkola HK, Gekas C, Helgadottir HB, Orkin SH. Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development. Blood. 105: 3871-4. PMID 15677556 DOI: 10.1182/Blood-2004-11-4467 |
0.486 |
|
| 2005 |
Cantor AB, Orkin SH. Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins. Seminars in Cell & Developmental Biology. 16: 117-28. PMID 15659346 DOI: 10.1016/J.Semcdb.2004.10.006 |
0.378 |
|
| 2005 |
Tsuneto M, Tominaga A, Yamazaki H, Yoshino M, Orkin SH, Hayashi S. Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. Stem Cells. 23: 134-143. PMID 15625130 DOI: 10.1634/Stemcells.2004-0154 |
0.48 |
|
| 2005 |
Mikkola HK, Orkin SH. Gene targeting and transgenic strategies for the analysis of hematopoietic development in the mouse. Methods in Molecular Medicine. 105: 3-22. PMID 15492385 DOI: 10.1385/1-59259-826-9:003 |
0.387 |
|
| 2005 |
Guyot B, Murai K, Fujiwara Y, Valverde-Garduno V, Hammett M, Wells S, Dear N, Orkin SH, Porcher C, Vyas P. Characterization of a Megakaryocyte-Specific Enhancer of the Key Hemopoietic Transcription Factor GATA1. Blood. 106: 834-834. DOI: 10.1182/Blood.V106.11.834.834 |
0.463 |
|
| 2005 |
Li Z, Klusmann J, Godinho FJ, Lee H, Reinhardt D, Orkin SH. A Genome-Wide Retroviral Insertional Mutagenesis Screen for Genes Cooperating with Truncated, Oncogenic GATA1s. Blood. 106: 2990-2990. DOI: 10.1182/Blood.V106.11.2990.2990 |
0.422 |
|
| 2004 |
Ling KW, Ottersbach K, van Hamburg JP, Oziemlak A, Tsai FY, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. The Journal of Experimental Medicine. 200: 871-82. PMID 15466621 DOI: 10.1084/Jem.20031556 |
0.418 |
|
| 2004 |
Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 431: 1002-7. PMID 15457180 DOI: 10.1038/Nature02994 |
0.443 |
|
| 2004 |
Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C. A critical role for eosinophils in allergic airways remodeling. Science (New York, N.Y.). 305: 1776-9. PMID 15375268 DOI: 10.1126/Science.1100283 |
0.514 |
|
| 2004 |
Hock H, Meade E, Medeiros S, Schindler JW, Valk PJ, Fujiwara Y, Orkin SH. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes & Development. 18: 2336-41. PMID 15371326 DOI: 10.1101/Gad.1239604 |
0.417 |
|
| 2004 |
Ransom DG, Bahary N, Niss K, Traver D, Burns C, Trede NS, Paffett-Lugassy N, Saganic WJ, Lim CA, Hersey C, Zhou Y, Barut BA, Lin S, Kingsley PD, Palis J, ... Orkin SH, et al. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. Plos Biology. 2: E237. PMID 15314655 DOI: 10.1371/Journal.Pbio.0020237 |
0.846 |
|
| 2004 |
Schlaeger TM, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin SH, Vyas P, Porcher C. Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Molecular and Cellular Biology. 24: 7491-502. PMID 15314159 DOI: 10.1128/Mcb.24.17.7491-7502.2004 |
0.392 |
|
| 2004 |
Garriga-Canut M, Orkin SH. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis Journal of Biological Chemistry. 279: 23597-23605. PMID 15037632 DOI: 10.1074/Jbc.M313987200 |
0.469 |
|
| 2004 |
Hahm K, Sum EY, Fujiwara Y, Lindeman GJ, Visvader JE, Orkin SH. Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Molecular and Cellular Biology. 24: 2074-82. PMID 14966286 DOI: 10.1128/Mcb.24.5.2074-2082.2004 |
0.445 |
|
| 2004 |
Roberts CW, Orkin SH. The SWI/SNF complex--chromatin and cancer. Nature Reviews. Cancer. 4: 133-42. PMID 14964309 DOI: 10.1038/Nrc1273 |
0.309 |
|
| 2004 |
Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD. More than blood, a novel gene required for mammalian postimplantation development. Molecular and Cellular Biology. 24: 1168-73. PMID 14729962 DOI: 10.1128/Mcb.24.3.1168-1173.2004 |
0.816 |
|
| 2004 |
Pal S, Cantor AB, Johnson KD, Moran TB, Boyer ME, Orkin SH, Bresnick EH. Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 101: 980-5. PMID 14715908 DOI: 10.1073/Pnas.0307612100 |
0.388 |
|
| 2004 |
Fujiwara Y, Chang AN, Williams AM, Orkin SH. Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood. 103: 583-5. PMID 14504093 DOI: 10.1182/Blood-2003-08-2870 |
0.708 |
|
| 2004 |
Li Z, Godinho F, Garriga-Canut M, Yu C, Orkin SH. Developmental Stage-Selective Effect of Somatically Mutated GATA-1 in Down Syndrome AML M7--a Potential Basis for Transient Myeloproliferative Disorder. Blood. 104: 463-463. DOI: 10.1182/Blood.V104.11.463.463 |
0.619 |
|
| 2004 |
Mikkola HKA, Gekas C, Dieterlen-Lievre F, Orkin SH. Placenta Is a Niche for Hematopoietic Stem Cells. Blood. 104: 2671-2671. DOI: 10.1182/Blood.V104.11.2671.2671 |
0.372 |
|
| 2004 |
Bourquin J, Langebrake C, Subramanian A, Li X, Reinhardt D, Bernard O, Zwaan CM, Hasle H, Schrappe M, Golub TR, Orkin SH. A Molecular Signature of the Transcription Factor GATA1 in Acute Megakaryoblastic Leukemia of Childhood. Blood. 104: 1117-1117. DOI: 10.1182/Blood.V104.11.1117.1117 |
0.308 |
|
| 2003 |
Orkin SH. Priming the hematopoietic pump Immunity. 19: 633-634. PMID 14614848 DOI: 10.1016/S1074-7613(03)00302-9 |
0.416 |
|
| 2003 |
Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings of the National Academy of Sciences of the United States of America. 100: 14030-5. PMID 14614148 DOI: 10.1073/Pnas.1936250100 |
0.361 |
|
| 2003 |
Fossett N, Hyman K, Gajewski K, Orkin SH, Schulz RA. Combinatorial interactions of serpent, lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 11451-6. PMID 14504400 DOI: 10.1073/Pnas.1635050100 |
0.4 |
|
| 2003 |
Neumann CA, Krause DS, Carman CV, Das S, Dubey DP, Abraham JL, Bronson RT, Fujiwara Y, Orkin SH, Van Etten RA. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature. 424: 561-5. PMID 12891360 DOI: 10.1038/Nature01819 |
0.312 |
|
| 2003 |
Ema M, Faloon P, Zhang WJ, Hirashima M, Reid T, Stanford WL, Orkin S, Choi K, Rossant J. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse Genes and Development. 17: 380-393. PMID 12569129 DOI: 10.1101/Gad.1049803 |
0.427 |
|
| 2003 |
Migliaccio AR, Rana RA, Sanchez M, Lorenzini R, Centurione L, Bianchi L, Vannucchi AM, Migliaccio G, Orkin SH. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. The Journal of Experimental Medicine. 197: 281-96. PMID 12566412 DOI: 10.1084/Jem.20021149 |
0.481 |
|
| 2003 |
Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 421: 547-51. PMID 12540851 DOI: 10.1038/Nature01345 |
0.502 |
|
| 2003 |
Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity. 18: 109-20. PMID 12530980 DOI: 10.1016/S1074-7613(02)00501-0 |
0.431 |
|
| 2003 |
Wallis D, Hamblen M, Zhou Y, Venken KJ, Schumacher A, Grimes HL, Zoghbi HY, Orkin SH, Bellen HJ. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development (Cambridge, England). 130: 221-32. PMID 12441305 DOI: 10.1242/Dev.00190 |
0.431 |
|
| 2003 |
Turner J, Holmes M, Czoli R, Gaensler K, Yang H, Fujiwara Y, Chong B, Koh P, Perkins A, Orkin S, Crossley M. Basic Kruppel-like factor recruits multiple co-repressors to silence gene expression Blood Cells Molecules and Diseases. 31: 135-136. DOI: 10.1016/S1079-9796(03)00043-3 |
0.389 |
|
| 2002 |
Endoh M, Ogawa M, Orkin S, Nishikawa Si. SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation The Embo Journal. 21: 6700-6708. PMID 12485991 DOI: 10.1093/Emboj/Cdf674 |
0.414 |
|
| 2002 |
Roberts CW, Leroux MM, Fleming MD, Orkin SH. Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell. 2: 415-25. PMID 12450796 DOI: 10.1016/S1535-6108(02)00185-X |
0.332 |
|
| 2002 |
Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood. 100: 2430-40. PMID 12239153 DOI: 10.1182/Blood-2002-02-0568 |
0.465 |
|
| 2002 |
Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH. Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development (Cambridge, England). 129: 4627-34. PMID 12223418 |
0.782 |
|
| 2002 |
Ritchie KJ, Malakhov MP, Hetherington CJ, Zhou L, Little MT, Malakhova OA, Sipe JC, Orkin SH, Zhang DE. Dysregulation of protein modification by ISG15 results in brain cell injury. Genes & Development. 16: 2207-12. PMID 12208842 DOI: 10.1101/Gad.1010202 |
0.315 |
|
| 2002 |
Yu C, Niakan KK, Matsushita M, Stamatoyannopoulos G, Orkin SH, Raskind WH. X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction. Blood. 100: 2040-5. PMID 12200364 DOI: 10.1182/Blood-2002-02-0387 |
0.577 |
|
| 2002 |
Orkin SH, Morrison SJ. Stem-cell competition. Nature. 418: 25-7. PMID 12097889 DOI: 10.1038/418025A |
0.389 |
|
| 2002 |
Chang AN, Cantor AB, Fujiwara Y, Lodish MB, Droho S, Crispino JD, Orkin SH. GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 9237-42. PMID 12077323 DOI: 10.1073/Pnas.142302099 |
0.745 |
|
| 2002 |
Crispino JD, Orkin SH. The use of altered specificity mutants to probe specific protein-protein interactions involved in the activation of GATA-1 target genes. Methods (San Diego, Calif.). 26: 84-92. PMID 12054907 DOI: 10.1016/S1046-2023(02)00010-5 |
0.571 |
|
| 2002 |
Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, Orkin SH. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. The Journal of Experimental Medicine. 195: 1387-95. PMID 12045237 DOI: 10.1084/Jem.20020656 |
0.64 |
|
| 2002 |
Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 21: 3368-76. PMID 12032775 DOI: 10.1038/Sj.Onc.1205326 |
0.434 |
|
| 2002 |
Cantor AB, Katz SG, Orkin SH. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Molecular and Cellular Biology. 22: 4268-79. PMID 12024038 DOI: 10.1128/Mcb.22.12.4268-4279.2002 |
0.425 |
|
| 2002 |
Katz SG, Cantor AB, Orkin SH. Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo. Molecular and Cellular Biology. 22: 3121-8. PMID 11940669 DOI: 10.1128/Mcb.22.9.3121-3128.2002 |
0.351 |
|
| 2002 |
Orkin SH, Zon LI. Hematopoiesis and stem cells: Plasticity versus development heterogeneity Nature Immunology. 3: 323-328. PMID 11919568 DOI: 10.1038/Ni0402-323 |
0.552 |
|
| 2002 |
Saleque S, Cameron S, Orkin SH. The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages Genes and Development. 16: 301-306. PMID 11825872 DOI: 10.1101/Gad.959102 |
0.389 |
|
| 2001 |
Murga M, Fernández-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, Balomenos D, Vicario A, Carrera AC, Orkin SH, Greenberg ME, Zubiaga AM. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 15: 959-70. PMID 11754817 DOI: 10.1016/S1074-7613(01)00254-0 |
0.347 |
|
| 2001 |
Han AP, Yu C, Lu L, Fujiwara Y, Browne C, Chin G, Fleming M, Leboulch P, Orkin SH, Chen JJ. Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. The Embo Journal. 20: 6909-18. PMID 11726526 DOI: 10.1093/Emboj/20.23.6909 |
0.626 |
|
| 2001 |
Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 414: 457-62. PMID 11719808 DOI: 10.1038/35106593 |
0.412 |
|
| 2001 |
Zhou M, Ouyang W, Gong Q, Katz SG, White JM, Orkin SH, Murphy KM. Friend of GATA-1 represses GATA-3-dependent activity in CD4+ T cells. The Journal of Experimental Medicine. 194: 1461-71. PMID 11714753 DOI: 10.1084/Jem.194.10.1461 |
0.354 |
|
| 2001 |
Zhu JW, Field SJ, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff RD, Greenberg M, Orkin SH, DeGregori J. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis Molecular and Cellular Biology. 21: 8547-8564. PMID 11713289 DOI: 10.1128/Mcb.21.24.8547-8564.2001 |
0.38 |
|
| 2001 |
Jasinski M, Keller P, Fujiwara Y, Orkin SH, Bessler M. GATA1-Cre mediates Piga gene inactivation in the erythroid/megakaryocytic lineage and leads to circulating red cells with a partial deficiency in glycosyl phosphatidylinositol-linked proteins (paroxysmal nocturnal hemoglobinuria type II cells). Blood. 98: 2248-2255. PMID 11568013 DOI: 10.1182/Blood.V98.7.2248 |
0.444 |
|
| 2001 |
Cantor AB, Orkin SH. Hematopoietic development: a balancing act. Current Opinion in Genetics & Development. 11: 513-9. PMID 11532392 DOI: 10.1016/S0959-437X(00)00226-4 |
0.452 |
|
| 2001 |
Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, et al. Myc requires distinct E2F activities to induce S phase and apoptosis. Molecular Cell. 8: 105-13. PMID 11511364 DOI: 10.1016/S1097-2765(01)00275-1 |
0.383 |
|
| 2001 |
Mead PE, Deconinck AE, Huber TL, Orkin SH, Zon LI. Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Development (Cambridge, England). 128: 2301-8. PMID 11493549 |
0.641 |
|
| 2001 |
Fossett N, Tevosian SG, Gajewski K, Zhang Q, Orkin SH, Schulz RA. The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 98: 7342-7. PMID 11404479 DOI: 10.1073/Pnas.131215798 |
0.729 |
|
| 2001 |
Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors Genes and Development. 15: 839-844. PMID 11297508 DOI: 10.1101/Gad.875201 |
0.551 |
|
| 2001 |
Mao X, Fujiwara Y, Chapdelaine A, Yang H, Orkin SH. Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood. 97: 324-6. PMID 11133778 DOI: 10.1182/Blood.V97.1.324 |
0.41 |
|
| 2001 |
Lassar AB, Orkin S. Cell differentiation: Plasticity and commitment - Developmental decisions in the life of a cell Current Opinion in Cell Biology. 13: 659-661. DOI: 10.1016/S0955-0674(00)00267-2 |
0.35 |
|
| 2000 |
Orkin SH. Diversification of haematopoietic stem cells to specific lineages Nature Reviews Genetics. 1: 57-64. PMID 11262875 DOI: 10.1038/35049577 |
0.432 |
|
| 2000 |
Roberts CWM, Galusha SA, McMenamin ME, Fletcher CDM, Orkin SH. Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice Proceedings of the National Academy of Sciences of the United States of America. 97: 13796-13800. PMID 11095756 DOI: 10.1073/Pnas.250492697 |
0.314 |
|
| 2000 |
Vyas P, Norris FA, Joseph R, Majerus PW, Orkin SH. Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 97: 13696-701. PMID 11087841 DOI: 10.1073/Pnas.250476397 |
0.419 |
|
| 2000 |
Orkin SH. Stem cell alchemy Nature Medicine. 6: 1212-1213. PMID 11062526 DOI: 10.1038/81303 |
0.405 |
|
| 2000 |
Zhang P, Zhang X, Iwama A, Yu C, Smith KA, Mueller BU, Narravula S, Torbett BE, Orkin SH, Tenen DG. PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood. 96: 2641-8. PMID 11023493 DOI: 10.1182/Blood.V96.8.2641 |
0.626 |
|
| 2000 |
Querfurth E, Schuster M, Kulessa H, Crispino JD, Döderlein G, Orkin SH, Graf T, Nerlov C. Antagonism between C/EBPβ and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors Genes and Development. 14: 2515-2525. PMID 11018018 DOI: 10.1101/Gad.177200 |
0.657 |
|
| 2000 |
Yamane T, Kunisada T, Yamazaki H, Nakano T, Orkin SH, Hayashi S. Sequential requirements for SCL/tal-1, GATA-2, macrophage colony-stimulating factor, and osteoclast differentiation factor/osteoprotegerin ligand in osteoclast development. Experimental Hematology. 28: 833-840. PMID 10907645 DOI: 10.1016/S0301-472X(00)00175-2 |
0.435 |
|
| 2000 |
Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Current Biology : Cb. 10: 758-65. PMID 10898977 DOI: 10.1016/S0960-9822(00)00571-6 |
0.434 |
|
| 2000 |
Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH. FOG-2, a Cofactor for GATA Transcription Factors, Is Essential for Heart Morphogenesis and Development of Coronary Vessels from Epicardium Cell. 101: 729-739. PMID 10892744 DOI: 10.1016/S0092-8674(00)80885-5 |
0.663 |
|
| 2000 |
Lewis BA, Kim TK, Orkin SH. A downstream element in the human β-globin promoter: Evidence of extended sequence-specific transcription factor IID contacts Proceedings of the National Academy of Sciences of the United States of America. 97: 7172-7177. PMID 10840054 DOI: 10.1073/Pnas.120181197 |
0.334 |
|
| 2000 |
Shirihai OS, Gregory T, Yu C, Orkin SH, Weiss MJ. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. The Embo Journal. 19: 2492-502. PMID 10835348 DOI: 10.1093/Emboj/19.11.2492 |
0.637 |
|
| 2000 |
Deconinck AE, Mead PE, Tevosian SG, Crispino JD, Katz SG, Zon LI, Orkin SH. FOG acts as a repressor of red blood cell development in Xenopus Development. 127: 2031-2040. PMID 10769228 |
0.694 |
|
| 2000 |
Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ. Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA 1 Nature Genetics. 24: 266-270. PMID 10700180 DOI: 10.1038/73480 |
0.63 |
|
| 2000 |
Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH. An essential role in liver development for transcription factor XBP-1. Genes & Development. 14: 152-7. PMID 10652269 DOI: 10.1101/Gad.14.2.152 |
0.362 |
|
| 2000 |
Kappel A, Schlaeger TM, Flamme I, Orkin SH, Risau W, Breier G. Role of SCL/Tal-1, GATA, and Ets transcription factor binding sites for the regulation of Flk-1 expression during murine vascular development Blood. 96: 3078-3085. DOI: 10.1182/Blood.V96.9.3078.H8003078_3078_3085 |
0.413 |
|
| 2000 |
Perkins AC, Peterson KR, Stamatoyannopoulos G, Witkowska HE, Orkin SH. Fetal expression of a human Aγ globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos Blood. 95: 1827-1833. DOI: 10.1182/Blood.V95.5.1827.004K10_1827_1833 |
0.405 |
|
| 1999 |
Orkin SH, Weiss MJ. Cutting red-cell production Nature. 401: 433-436. PMID 10519540 DOI: 10.1038/46699 |
0.335 |
|
| 1999 |
Porcher C, Liao EC, Fujiwara Y, Zon LI, Orkin SH. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development (Cambridge, England). 126: 4603-15. PMID 10498694 |
0.5 |
|
| 1999 |
Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-x(L) expression Blood. 94: 87-96. PMID 10381501 |
0.737 |
|
| 1999 |
Strauss EC, Orkin SH. Guanine-adenine ligation-mediated polymerase chain reaction in vivo footprinting Methods in Enzymology. 304: 572-584. PMID 10372382 DOI: 10.1016/S0076-6879(99)04033-1 |
0.391 |
|
| 1999 |
Nardelli J, Thiesson D, Fujiwara Y, Tsai F, Orkin SH. Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Developmental Biology. 210: 305-321. PMID 10357893 DOI: 10.1006/Dbio.1999.9278 |
0.387 |
|
| 1999 |
Mao X, Fujiwara Y, Orkin SH. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice Proceedings of the National Academy of Sciences of the United States of America. 96: 5037-5042. PMID 10220414 DOI: 10.1073/Pnas.96.9.5037 |
0.346 |
|
| 1999 |
Crispino JD, Lodish MB, MacKay JP, Orkin SH. Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: The GATA-1:FOG complex Molecular Cell. 3: 219-228. PMID 10078204 DOI: 10.1016/S1097-2765(00)80312-3 |
0.593 |
|
| 1999 |
Tevosian SG, Deconinck AE, Cantor AB, Rieff HI, Fujiwara Y, Corfas G, Orkin SH. FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proceedings of the National Academy of Sciences of the United States of America. 96: 950-5. PMID 9927674 DOI: 10.1073/Pnas.96.3.950 |
0.724 |
|
| 1999 |
Gregory T, Yu C, Ma A, Orkin SH, Blobel GA, Weiss MJ. GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression Blood. 94: 87-96. DOI: 10.1182/Blood.V94.1.87.413K41_87_96 |
0.754 |
|
| 1999 |
Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA. Consequences of GATA-1 Deficiency in Megakaryocytes and Platelets Blood. 93: 2867-2875. DOI: 10.1182/Blood.V93.9.2867.409K24_2867_2875 |
0.37 |
|
| 1998 |
Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA. Transcription factor GATA-1 in megakaryocyte development Stem Cells (Dayton, Ohio). 16: 79-83. PMID 11012179 DOI: 10.1002/Stem.5530160710 |
0.447 |
|
| 1998 |
Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, ... ... Orkin SH, et al. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 95: 891-902. PMID 9875844 DOI: 10.1016/S0092-8674(00)81714-6 |
0.342 |
|
| 1998 |
Orkin SH. Embryonic stem cells and transgenic mice in the study of hematopoiesis International Journal of Developmental Biology. 42: 927-934. PMID 9853823 DOI: 10.1387/Ijdb.9853823 |
0.525 |
|
| 1998 |
Zhou Y, Lim KC, Onodera K, Takahashi S, Ohta J, Minegishi N, Tsai FY, Orkin SH, Yamamoto M, Engel JD. Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development Embo Journal. 17: 6689-6700. PMID 9822612 DOI: 10.1093/Emboj/17.22.6689 |
0.45 |
|
| 1998 |
Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, Alt FW, Gilliland DG, Golub TR, Orkin SH. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes & Development. 12: 2392-402. PMID 9694803 DOI: 10.1101/Gad.12.15.2392 |
0.386 |
|
| 1998 |
Tsai FY, Browne CP, Orkin SH. Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Developmental Biology. 196: 218-27. PMID 9576834 DOI: 10.1006/Dbio.1997.8842 |
0.496 |
|
| 1998 |
Tsang AP, Fujiwara Y, Horn DB, Orkin SH. Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG Genes and Development. 12: 1176-1188. PMID 9553047 DOI: 10.1101/Gad.12.8.1176 |
0.479 |
|
| 1998 |
Blobel GA, Nakajima T, Eckner R, Montminy M, Orkin SH. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation Proceedings of the National Academy of Sciences of the United States of America. 95: 2061-2066. PMID 9482838 DOI: 10.1073/Pnas.95.5.2061 |
0.665 |
|
| 1998 |
Visvader JE, Fujiwara Y, Orkin SH. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes & Development. 12: 473-9. PMID 9472016 DOI: 10.1101/Gad.12.4.473 |
0.381 |
|
| 1998 |
Guy LG, Mei Q, Perkins AC, Orkin SH, Wall L. Erythroid Krüppel-Like Factor Is Essential for β-Globin Gene Expression Even in Absence of Gene Competition, But Is Not Sufficient to Induce the Switch From γ-Globin to β-Globin Gene Expression Blood. 91: 2259-2263. DOI: 10.1182/Blood.V91.7.2259.2259_2259_2263 |
0.386 |
|
| 1997 |
Orkin SH, Zon LI. Genetics of erythropoiesis: Induced mutations in mice and zebrafish Annual Review of Genetics. 31: 33-60. PMID 9442889 DOI: 10.1146/Annurev.Genet.31.1.33 |
0.591 |
|
| 1997 |
Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proceedings of the National Academy of Sciences of the United States of America. 94: 13707-12. PMID 9391090 DOI: 10.1073/Pnas.94.25.13707 |
0.455 |
|
| 1997 |
Deveaux S, Cohen-Kaminsky S, Shivdasani RA, Andrews NC, Filipe A, Kuzniak I, Orkin SH, Roméo PH, Mignotte V. p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. The Embo Journal. 16: 5654-61. PMID 9312024 DOI: 10.1093/Emboj/16.18.5654 |
0.379 |
|
| 1997 |
Qu C, Shi ZQ, Shen R, Tsai FY, Orkin SH, Feng GS. A Deletion Mutation in the SH2-N Domain of Shp-2 Severely Suppresses Hematopoietic Cell Development Molecular and Cellular Biology. 17: 5499-5507. PMID 9271425 DOI: 10.1128/Mcb.17.9.5499 |
0.47 |
|
| 1997 |
Wang LC, Kuo F, Fujiwara Y, Gilliland DG, Golub TR, Orkin SH. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. The Embo Journal. 16: 4374-83. PMID 9250681 DOI: 10.1093/Emboj/16.14.4374 |
0.397 |
|
| 1997 |
Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. The Embo Journal. 16: 3965-73. PMID 9233806 DOI: 10.1093/Emboj/16.13.3965 |
0.491 |
|
| 1997 |
Tsang AP, Visvader JE, Turner CA, Fujiwara Y, Yu C, Weiss MJ, Crossley M, Orkin SH. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 90: 109-19. PMID 9230307 DOI: 10.1016/S0092-8674(00)80318-9 |
0.672 |
|
| 1997 |
McDevitt MA, Fujiwara Y, Shivdasani RA, Orkin SH. An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 7976-81. PMID 9223298 DOI: 10.1073/Pnas.94.15.7976 |
0.455 |
|
| 1997 |
McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH. A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 94: 6781-5. PMID 9192642 DOI: 10.1073/Pnas.94.13.6781 |
0.463 |
|
| 1997 |
Tsai FY, Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation Blood. 89: 3636-3643. PMID 9160668 DOI: 10.1182/Blood.V89.10.3636.3636_3636_3643 |
0.467 |
|
| 1997 |
Lien LL, Lee Y, Orkin SH. Regulation of the myeloid-cell-expressed human gp91-phox gene as studied by transfer of yeast artificial chromosome clones into embryonic stem cells: Suppression of a variegated cellular pattern of expression requires a full complement of distant cis elements Molecular and Cellular Biology. 17: 2279-2290. PMID 9121478 DOI: 10.1128/Mcb.17.4.2279 |
0.488 |
|
| 1997 |
Weiss MJ, Yu C, Orkin SH. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line. Molecular and Cellular Biology. 17: 1642-51. PMID 9032291 DOI: 10.1128/Mcb.17.3.1642 |
0.673 |
|
| 1997 |
Strauss EC, Orkin SH. Guanine-adenine ligation-mediated PCR in vivo footprinting Methods: a Companion to Methods in Enzymology. 11: 164-170. PMID 8993028 DOI: 10.1006/Meth.1996.0402 |
0.39 |
|
| 1997 |
Shivdasani RA, Fielder P, Keller G, Orkin SH, de Sauvage FJ. Regulation of the Serum Concentration of Thrombopoietin in Thrombocytopenic NF-E2 Knockout Mice Blood. 90: 1821-1827. DOI: 10.1182/Blood.V90.5.1821 |
0.314 |
|
| 1997 |
Strauss EC, Orkin SH. Analysis of the GATA-1 Gene Promoter and Globin Locus Control Region Elements by in Vivo Footprinting Advances in Molecular and Cell Biology. 21: 135-158. DOI: 10.1016/S1569-2558(08)60285-4 |
0.428 |
|
| 1996 |
Orkin SH. Development of the hematopoietic system Current Opinion in Genetics and Development. 6: 597-602. PMID 8939717 DOI: 10.1016/S0959-437X(96)80089-X |
0.409 |
|
| 1996 |
Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 93: 12355-8. PMID 8901585 DOI: 10.1073/Pnas.93.22.12355 |
0.495 |
|
| 1996 |
Perkins AC, Gaensler KML, Orkin SH. Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF. Proceedings of the National Academy of Sciences of the United States of America. 93: 12267-12271. PMID 8901569 DOI: 10.1073/Pnas.93.22.12267 |
0.394 |
|
| 1996 |
Kieran MW, Perkins AC, Orkin SH, Zon LI. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proceedings of the National Academy of Sciences of the United States of America. 93: 9126-31. PMID 8799165 DOI: 10.1073/Pnas.93.17.9126 |
0.54 |
|
| 1996 |
Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW, Orkin SH. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 86: 47-57. PMID 8689686 DOI: 10.1016/S0092-8674(00)80076-8 |
0.458 |
|
| 1996 |
Crossley M, Whitelaw E, Perkins A, Williams G, Fujiwara Y, Orkin SH. Isolation And Characterization Of The Cdna Encoding Bklf/Tef-2, A Major Caccc-Box-Binding Protein In Erythroid Cells And Selected Other Cells Molecular and Cellular Biology. 16: 1695-1705. PMID 8657145 DOI: 10.1128/Mcb.16.4.1695 |
0.493 |
|
| 1996 |
Blobel GA, Orkin SH. Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1 Molecular and Cellular Biology. 16: 1687-1694. PMID 8657144 DOI: 10.1128/Mcb.16.4.1687 |
0.592 |
|
| 1996 |
Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 85: 549-61. PMID 8653790 DOI: 10.1016/S0092-8674(00)81255-6 |
0.568 |
|
| 1996 |
Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis Blood. 87: 4025-4039. PMID 8639758 DOI: 10.1182/Blood.V87.10.4025.Bloodjournal87104025 |
0.317 |
|
| 1996 |
Kotkow KJ, Orkin SH. Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus Proceedings of the National Academy of Sciences of the United States of America. 93: 3514-3518. PMID 8622968 DOI: 10.1073/Pnas.93.8.3514 |
0.323 |
|
| 1996 |
Weiss MJ, Orkin SH. In vitro differentiation of murine embryonic stem cells: New approaches to old problems Journal of Clinical Investigation. 97: 591-595. PMID 8609212 DOI: 10.1172/Jci118454 |
0.372 |
|
| 1995 |
Orkin SH. Hematopoiesis: how does it happen? Current Opinion in Cell Biology. 7: 870-877. PMID 8608018 DOI: 10.1016/0955-0674(95)80072-7 |
0.464 |
|
| 1995 |
Orkin SH. Transcription factors and hematopoietic development Journal of Biological Chemistry. 270: 4955-4958. PMID 7890597 DOI: 10.1074/Jbc.270.10.4955 |
0.364 |
|
| 1995 |
Shivdasanl RA, Mayer EL, Orkin SH. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL Nature. 373: 432-434. PMID 7830794 DOI: 10.1038/373432A0 |
0.488 |
|
| 1995 |
Visvader JE, Crossley M, Hill J, Orkin SH, Adams JM. The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line. Molecular and Cellular Biology. 15: 634-41. PMID 7823932 DOI: 10.1128/Mcb.15.2.634 |
0.43 |
|
| 1995 |
Blobel GA, Simon MC, Orkin SH. Rescue of GATA-1-deficient embryonic stem cells by heterologous GATA- binding proteins Molecular and Cellular Biology. 15: 626-633. PMID 7823931 DOI: 10.1128/Mcb.15.2.626 |
0.688 |
|
| 1995 |
Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 81: 695-704. PMID 7774011 DOI: 10.1016/0092-8674(95)90531-6 |
0.325 |
|
| 1995 |
Blobel GA, Sieff CA, Orkin SH. Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor Molecular and Cellular Biology. 15: 3147-3153. PMID 7760810 DOI: 10.1128/Mcb.15.6.3147 |
0.634 |
|
| 1995 |
Parkins AC, Sharpe AH, Orkin SH. Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF Nature. 375: 318-322. PMID 7753195 DOI: 10.1038/375318A0 |
0.387 |
|
| 1995 |
Crossley M, Merika M, Orkin SH. Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains Molecular and Cellular Biology. 15: 2448-2456. PMID 7739529 DOI: 10.1128/Mcb.15.5.2448 |
0.433 |
|
| 1995 |
Merika M, Orkin SH. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF Molecular and Cellular Biology. 15: 2437-2447. PMID 7739528 DOI: 10.1128/Mcb.15.5.2437 |
0.425 |
|
| 1995 |
Chui DHK, Tang W, Orkin SH. cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor Biochemical and Biophysical Research Communications. 209: 40-46. PMID 7726861 DOI: 10.1006/Bbrc.1995.1467 |
0.339 |
|
| 1995 |
Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. The Journal of Experimental Medicine. 181: 1603-13. PMID 7722440 DOI: 10.1084/Jem.181.5.1603 |
0.569 |
|
| 1995 |
Zhang R, Alt FW, Davidson L, Orkin SH, Swat W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature. 374: 470-3. PMID 7700359 DOI: 10.1038/374470A0 |
0.35 |
|
| 1995 |
Orkin SH. Regulation of globin gene expression in erythroid cells European Journal of Biochemistry. 231: 271-281. PMID 7635138 DOI: 10.1111/J.1432-1033.1995.0271E.X |
0.471 |
|
| 1995 |
Kotkow KJ, Orkin SH. Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer Molecular and Cellular Biology. 15: 4640-4647. PMID 7623856 DOI: 10.1128/Mcb.15.8.4640 |
0.365 |
|
| 1995 |
Weiss MJ, Orkin SH. Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis Proceedings of the National Academy of Sciences of the United States of America. 92: 9623-9627. PMID 7568185 DOI: 10.1073/Pnas.92.21.9623 |
0.531 |
|
| 1995 |
Shivdasani RA, Orkin SH. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2 Proceedings of the National Academy of Sciences of the United States of America. 92: 8690-8694. PMID 7567998 DOI: 10.1073/Pnas.92.19.8690 |
0.414 |
|
| 1994 |
Andrews NC, Orkin SH. Transcriptional control of erythropoiesis Current Opinion in Hematology. 1: 119-124. PMID 9371270 |
0.317 |
|
| 1994 |
Crossley M, Tsang AP, Bieker JJ, Orkin SH. Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1 Journal of Biological Chemistry. 269: 15440-15444. PMID 8195185 |
0.309 |
|
| 1994 |
Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 371: 221-6. PMID 8078582 DOI: 10.1038/371221A0 |
0.501 |
|
| 1994 |
Weiss MJ, Keller G, Orkin SH. Novel insights into erythroid development revealed through in vitro differentiation of GATA-1- embryonic stem cells Genes and Development. 8: 1184-1197. PMID 7926723 DOI: 10.1101/Gad.8.10.1184 |
0.514 |
|
| 1994 |
Zhang R, Tsai FY, Orkin SH. Hematopoietic development of vav-/- mouse embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America. 91: 12755-12759. PMID 7809116 DOI: 10.1073/Pnas.91.26.12755 |
0.471 |
|
| 1994 |
Peters LL, Andrews NC, Eicher EM, Davidson MB, Orkin SH, Lux SE. Correction: Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2 Nature. 371: 358-358. DOI: 10.1038/371358B0 |
0.314 |
|
| 1993 |
Zon LI, Yamaguchi Y, Yee K, Albee EA, Kimura A, Bennett JC, Orkin SH, Ackerman SJ. Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood. 81: 3234-41. PMID 8507862 DOI: 10.1182/Blood.V81.12.3234.Bloodjournal81123234 |
0.539 |
|
| 1993 |
Crossley M, Orkin SH. Regulation of the β-globin locus Current Opinion in Genetics and Development. 3: 232-237. PMID 8504248 DOI: 10.1016/0959-437X(93)90028-N |
0.362 |
|
| 1993 |
Peters LL, Andrews NC, Eicher EM, Davidson MB, Orkin SH, Lux SE. Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Nature. 362: 768-770. PMID 8469289 DOI: 10.1038/362768A0 |
0.369 |
|
| 1993 |
Andrews NC, Erdjument-Bromage H, Davidson MB, Tempst P, Orkin SH. Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. Nature. 362: 722-8. PMID 8469283 DOI: 10.1038/362722A0 |
0.352 |
|
| 1993 |
Scherer SW, Neufeld EJ, Lievens P, Orkin SH, Kim J, Tsui LC. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids Genomics. 15: 695-696. PMID 8468066 DOI: 10.1006/Geno.1993.1130 |
0.334 |
|
| 1993 |
Arceci RJ, King AA, Simon MC, Orkin SH, Wilson DB. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Molecular and Cellular Biology. 13: 2235-46. PMID 8455608 DOI: 10.1128/Mcb.13.4.2235 |
0.441 |
|
| 1993 |
Kreider BL, Orkin SH, Ihle JN. Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene Proceedings of the National Academy of Sciences of the United States of America. 90: 6454-6458. PMID 8341654 DOI: 10.1073/Pnas.90.14.6454 |
0.479 |
|
| 1993 |
Merika M, Orkin SH. DNA-binding specificity of GATA family transcription factors Molecular and Cellular Biology. 13: 3999-4010. PMID 8321207 DOI: 10.1128/Mcb.13.7.3999 |
0.35 |
|
| 1993 |
Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P, Orkin SH. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene Proceedings of the National Academy of Sciences of the United States of America. 90: 11488-11492. PMID 8265578 DOI: 10.1073/Pnas.90.24.11488 |
0.338 |
|
| 1993 |
Zhen L, King AA, Xiao Y, Chanock SJ, Orkin SH, Dinauer MC. Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. Proceedings of the National Academy of Sciences of the United States of America. 90: 9832-6. PMID 8234321 DOI: 10.1073/Pnas.90.21.9832 |
0.359 |
|
| 1993 |
Bodine DM, Moritz T, Donahue RE, Luskey BD, Kessler SW, Martin DI, Orkin SH, Nienhuis AW, Williams DA. Long-term in vivo expression of a murine adenosine deaminase gene in rhesus monkey hematopoietic cells of multiple lineages after retroviral mediated gene transfer into CD34+ bone marrow cells. Blood. 82: 1975-80. PMID 7691243 DOI: 10.1182/Blood.V82.7.1975.Bloodjournal8271975 |
0.447 |
|
| 1993 |
Simon MC, Pevny L, Wiles MV, Keller G, Costantini F, Orkin SH. Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nature Genetics. 1: 92-8. PMID 1302015 DOI: 10.1038/Ng0592-92 |
0.517 |
|
| 1992 |
Orkin SH. GATA-binding transcription factors in hematopoietic cells Blood. 80: 575-581. PMID 1638017 DOI: 10.1182/Blood.V80.3.575.Bloodjournal803575 |
0.402 |
|
| 1992 |
Sposi NM, Zon LI, Carè A, Valtieri M, Testa U, Gabbianelli M, Mariani G, Bottero L, Mather C, Orkin SH. Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors. Proceedings of the National Academy of Sciences of the United States of America. 89: 6353-7. PMID 1631130 DOI: 10.1073/Pnas.89.14.6353 |
0.613 |
|
| 1992 |
Strauss EC, Orkin SH. In vivo protein-DNA interactions at hypersensitive site 3 of the human β- globin locus control region Proceedings of the National Academy of Sciences of the United States of America. 89: 5809-5813. PMID 1631062 DOI: 10.1073/Pnas.89.13.5809 |
0.408 |
|
| 1992 |
Zon LI, Orkin SH. Sequence of the human GATA-1 promoter Nucleic Acids Research. 20: 1812. PMID 1579480 DOI: 10.1093/Nar/20.7.1812 |
0.448 |
|
| 1992 |
Strauss EC, Andrews NC, Higgs DR, Orkin SH. In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction. Molecular and Cellular Biology. 12: 2135-42. PMID 1569944 DOI: 10.1128/Mcb.12.5.2135 |
0.38 |
|
| 1992 |
Aplan PD, Nakahara K, Orkin SH, Kirsch IR. The SCL gene product: A positive regulator of erythroid differentiation Embo Journal. 11: 4073-4081. PMID 1396592 DOI: 10.1002/J.1460-2075.1992.Tb05500.X |
0.49 |
|
| 1992 |
Neufeld EJ, Skalnik DG, Lievens PMJ, Orkin SH. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut Nature Genetics. 1: 50-55. PMID 1301999 DOI: 10.1038/Ng0492-50 |
0.378 |
|
| 1991 |
Luskey BD, Lim B, Apperley JF, Orkin SH, Williams DA. Gene transfer into murine hematopoietic stem cells and bone marrow stromal cells. Annals of the New York Academy of Sciences. 612: 398-406. PMID 2291566 DOI: 10.1111/J.1749-6632.1990.Tb24327.X |
0.425 |
|
| 1991 |
Tsai SF, Strauss E, Orkin SH. Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter Genes and Development. 5: 919-931. PMID 2044960 DOI: 10.1101/Gad.5.6.919 |
0.483 |
|
| 1991 |
Chapman VM, Stephenson DA, Mullins LJ, Keitz BT, Disteche C, Orkin SH. Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice. Genomics. 9: 309-13. PMID 2004781 DOI: 10.1016/0888-7543(91)90258-G |
0.322 |
|
| 1991 |
Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH, Costantini F. Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 349: 257-60. PMID 1987478 DOI: 10.1038/349257A0 |
0.508 |
|
| 1991 |
Zon LI, Mather C, Burgess S, Bolce ME, Harland RM, Orkin SH. Expression of GATA-binding proteins during embryonic development in Xenopus laevis. Proceedings of the National Academy of Sciences of the United States of America. 88: 10642-6. PMID 1961730 DOI: 10.1073/Pnas.88.23.10642 |
0.527 |
|
| 1991 |
Marsden PA, Dorfman DM, Collins T, Brenner BM, Orkin SH, Ballermann BJ. Regulated expression of endothelin 1 in glomerular capillary endothelial cells American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 261. PMID 1858892 DOI: 10.1152/Ajprenal.1991.261.1.F117 |
0.357 |
|
| 1991 |
Ho IC, Vorhees P, Marin N, Oakley BK, Tsai SF, Orkin SH, Leiden JM. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. The Embo Journal. 10: 1187-92. PMID 1827068 DOI: 10.1002/J.1460-2075.1991.Tb08059.X |
0.37 |
|
| 1991 |
Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. The Journal of Biological Chemistry. 266: 22948-53. PMID 1744088 |
0.546 |
|
| 1991 |
Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH. Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proceedings of the National Academy of Sciences of the United States of America. 88: 10638-41. PMID 1660143 DOI: 10.1073/Pnas.88.23.10638 |
0.618 |
|
| 1991 |
Skalnik DG, Dorfman DM, Perkins AS, Jenkins NA, Copeland NG, Orkin SH. Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies Proceedings of the National Academy of Sciences of the United States of America. 88: 8505-8509. PMID 1656446 DOI: 10.1073/Pnas.88.19.8505 |
0.393 |
|
| 1991 |
ZON L, ROSSENBERG H, BENNETT J, ORKIN S, ACKERMAN S. 843 Potential role of the hematopoietic DNA-binding protein gata-1 in control of eosinophil specific gene transcription Journal of Allergy and Clinical Immunology. 87: 350. DOI: 10.1016/0091-6749(91)92125-K |
0.528 |
|
| 1990 |
Wilson DB, Dorfman DM, Orkin SH. A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells Molecular and Cellular Biology. 10: 4854-4862. PMID 2388628 DOI: 10.1128/Mcb.10.9.4854 |
0.455 |
|
| 1990 |
Martin DI, Zon LI, Mutter G, Orkin SH. Expression of an erythroid transcription factor in megakaryocytic and mast cell lineages. Nature. 344: 444-7. PMID 2320112 DOI: 10.1038/344444A0 |
0.624 |
|
| 1990 |
Mendoza AE, Young R, Orkin SH, Collins T. Increased platelet-derived growth factor A-chain expression in human uterine smooth muscle cells during the physiologic hypertrophy of pregnancy. Proceedings of the National Academy of Sciences of the United States of America. 87: 2177-81. PMID 2315311 DOI: 10.1073/Pnas.87.6.2177 |
0.346 |
|
| 1990 |
Zon LI, Tsai SF, Burgess S, Matsudaira P, Bruns GAP, Orkin SH. The major human erythroid DNA-binding protein (GF-1): Primary sequence and localization of the gene to the X chromosome Proceedings of the National Academy of Sciences of the United States of America. 87: 668-672. PMID 2300555 DOI: 10.1073/Pnas.87.2.668 |
0.537 |
|
| 1990 |
Martin DIK, Orkin SH. Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1 Genes and Development. 4: 1886-1898. PMID 2276623 DOI: 10.1101/Gad.4.11.1886 |
0.357 |
|
| 1990 |
Yamamoto M, Ko LJ, Leonard MW, Beug H, Orkin SH, Engel JD. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family. Genes & Development. 4: 1650-1662. PMID 2249770 DOI: 10.1101/Gad.4.10.1650 |
0.4 |
|
| 1990 |
Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. The Journal of Clinical Investigation. 86: 1729-37. PMID 2243141 DOI: 10.1172/Jci114898 |
0.304 |
|
| 1990 |
Young RM, Mendoza AE, Collins T, Orkin SH. Alternatively spliced platelet-derived growth factor A-chain transcripts are not tumor specific but encode normal cellular proteins. Molecular and Cellular Biology. 10: 6051-4. PMID 2233732 DOI: 10.1128/Mcb.10.11.6051 |
0.302 |
|
| 1990 |
Orkin SH. Globin gene regulation and switching: Circa 1990 Cell. 63: 665-672. PMID 2225071 DOI: 10.1016/0092-8674(90)90133-Y |
0.467 |
|
| 1990 |
Youssoufian H, Zon LI, Orkin SH, D'Andrea AD, Lodish HF. Structure and transcription of the mouse erythropoietin receptor gene. Molecular and Cellular Biology. 10: 3675-82. PMID 2162479 DOI: 10.1128/Mcb.10.7.3675 |
0.582 |
|
| 1990 |
Gessler M, Poustka A, Cavenee W, Neve RL, Orkin SH, Bruns GA. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature. 343: 774-8. PMID 2154702 DOI: 10.1038/343774A0 |
0.373 |
|
| 1990 |
Orkin SH. Cell-specific transcription and cell differentiation in the erythroid lineage Current Opinion in Cell Biology. 2: 1003-1012. PMID 1966005 DOI: 10.1016/0955-0674(90)90149-9 |
0.465 |
|
| 1990 |
Whitelaw E, Tsai SF, Hogben P, Orkin SH. Regulated expression of globin chains and the erythroid transcription factor GATA-1 during erythropoiesis in the developing mouse Molecular and Cellular Biology. 10: 6596-6606. PMID 1701019 DOI: 10.1128/Mcb.10.12.6596 |
0.406 |
|
| 1990 |
Ezekowitz R, Sieff C, Dinauer M, Nathan D, Orkin S, Newburger P. Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell Blood. 76: 2443-2448. DOI: 10.1182/Blood.V76.12.2443.2443 |
0.371 |
|
| 1989 |
Hirschhorn R, Tzall S, Ellenbogen A, Orkin SH. Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency Journal of Clinical Investigation. 83: 497-501. PMID 2783588 DOI: 10.1172/Jci113909 |
0.311 |
|
| 1989 |
Wise RJ, Orkin SH, Collins T. Aberrant expression of platelet-derived growth factor a-chaln cDNAs due to cryptic spiking of RNA transcripts in COS-1 cells Nucleic Acids Research. 17: 6591-6601. PMID 2780289 DOI: 10.1093/Nar/17.16.6591 |
0.335 |
|
| 1989 |
Tsai SF, Martin DI, Zon LI, D'Andrea AD, Wong GG, Orkin SH. Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature. 339: 446-51. PMID 2725678 DOI: 10.1038/339446A0 |
0.574 |
|
| 1989 |
Lim B, Apperley JF, Orkin SH, Williams DA. Long-term expression of human adenosine deaminase in mice transplanted with retrovirus-infected hematopoietic stem cells Proceedings of the National Academy of Sciences of the United States of America. 86: 8892-8896. PMID 2573068 DOI: 10.1073/Pnas.86.22.8892 |
0.408 |
|
| 1989 |
Dorfman DM, Zon LI, Orkin SH. Rapid amplification of lambda gt11 bacteriophage library inserts from plaques using the polymerase chain reaction (PCR) Biotechniques. 7. PMID 2534350 |
0.308 |
|
| 1989 |
Miller BA, Salameh M, Ahmed M, Olivieri N, Huisman THJ, Orkin SH, Nathan DG. Saudi Arabian sickle cell anemia. A molecular approach Annals of the New York Academy of Sciences. 565: 143-151. PMID 2476059 DOI: 10.1111/J.1749-6632.1989.Tb24161.X |
0.311 |
|
| 1989 |
Martin DIK, Tsai SF, Orkin SH. Increased γ-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor Nature. 338: 435-438. PMID 2467208 DOI: 10.1038/338435A0 |
0.435 |
|
| 1988 |
Collins T, Bonthron DT, Orkin SH. Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain Nature. 328: 621-624. PMID 3614364 DOI: 10.1038/328621A0 |
0.364 |
|
| 1988 |
Bonthron DT, Morton CC, Orkin SH, Collins T. Platelet-derived growth factor A chain: Gene structure, chromosomal location, and basis for alternative mRNA splicing Proceedings of the National Academy of Sciences of the United States of America. 85: 1492-1496. PMID 3422746 DOI: 10.1073/Pnas.85.5.1492 |
0.352 |
|
| 1988 |
Parkos CA, Dinauer MC, Walker LE, Allen RA, Jesaitis AJ, Orkin SH. Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b Proceedings of the National Academy of Sciences of the United States of America. 85: 3319-3323. PMID 3368442 DOI: 10.1073/Pnas.85.10.3319 |
0.324 |
|
| 1988 |
Barker KA, Orkin SH, Newburger PE. Expression of the X-CGD gene during induced differentiation of myeloid leukemia cell line HL-60. Molecular and Cellular Biology. 8: 2804-10. PMID 3165493 DOI: 10.1128/Mcb.8.7.2804 |
0.424 |
|
| 1988 |
Wise RJ, Pittman DD, Handin RI, Kaufman RJ, Orkin SH. The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers. Cell. 52: 229-36. PMID 3124962 DOI: 10.1016/0092-8674(88)90511-9 |
0.352 |
|
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