Roger K. Sunahara - Publications

Affiliations: 
Chemical Biology University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
General, General Biophysics, Pharmacology

89/132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Xu X, Shonberg J, Kaindl J, Clark MJ, Stößel A, Maul L, Mayer D, Hübner H, Hirata K, Venkatakrishnan AJ, Dror RO, Kobilka BK, Sunahara RK, Liu X, Gmeiner P. Constrained catecholamines gain βAR selectivity through allosteric effects on pocket dynamics. Nature Communications. 14: 2138. PMID 37059717 DOI: 10.1038/s41467-023-37808-y  0.337
2023 Huang SK, Picard LP, Rahmatullah RSM, Pandey A, Van Eps N, Sunahara RK, Ernst OP, Sljoka A, Prosser RS. Mapping the conformational landscape of the stimulatory heterotrimeric G protein. Nature Structural & Molecular Biology. PMID 36997760 DOI: 10.1038/s41594-023-00957-1  0.438
2021 Huang SK, Pandey A, Tran DP, Villanueva NL, Kitao A, Sunahara RK, Sljoka A, Prosser RS. Delineating the conformational landscape of the adenosine A receptor during G protein coupling. Cell. PMID 33743210 DOI: 10.1016/j.cell.2021.02.041  0.47
2020 Maeda S, Xu J, N Kadji FM, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK. Structure and selectivity engineering of the M muscarinic receptor toxin complex. Science (New York, N.Y.). 369: 161-167. PMID 32646996 DOI: 10.1126/Science.Aax2517  0.47
2020 Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM. Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature. PMID 32528175 DOI: 10.1038/S41586-020-2379-5  0.536
2020 Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, et al. An allosteric modulator binds to a conformational hub in the β adrenergic receptor. Nature Chemical Biology. PMID 32483378 DOI: 10.1038/S41589-020-0549-2  0.469
2019 Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, ... ... Sunahara R, et al. Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. Nature Structural & Molecular Biology. PMID 31740855 DOI: 10.1038/S41594-019-0330-Y  0.49
2018 Glukhova A, Draper-Joyce CJ, Sunahara RK, Christopoulos A, Wootten D, Sexton PM. Rules of Engagement: GPCRs and G Proteins. Acs Pharmacology & Translational Science. 1: 73-83. PMID 32219204 DOI: 10.1021/acsptsci.8b00026  0.457
2018 Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, ... ... Sunahara RK, et al. Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. Proceedings of the National Academy of Sciences of the United States of America. PMID 30404914 DOI: 10.1073/Pnas.1813988115  0.366
2018 Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, et al. Structural insights into binding specificity, efficacy and bias of a βAR partial agonist. Nature Chemical Biology. 14: 1059-1066. PMID 30327561 DOI: 10.1038/S41589-018-0145-X  0.476
2018 Valnohova J, Kowalski-Jahn M, Sunahara RK, Schulte G. Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment. The Journal of Biological Chemistry. PMID 30237173 DOI: 10.1074/Jbc.Ra118.004763  0.454
2018 Livingston KE, Mahoney JP, Manglik A, Sunahara R, Traynor JR. Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. Elife. 7. PMID 29932421 DOI: 10.7554/Elife.32499  0.483
2018 Ye L, Neale C, Sljoka A, Lyda B, Pichugin D, Tsuchimura N, Larda ST, Pomès R, García AE, Ernst OP, Sunahara RK, Prosser RS. Mechanistic insights into allosteric regulation of the A adenosine G protein-coupled receptor by physiological cations. Nature Communications. 9: 1372. PMID 29636462 DOI: 10.1038/S41467-018-03314-9  0.527
2018 Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, ... ... Sunahara RK, et al. Structure-based discovery of selective positive allosteric modulators of antagonists for the Mmuscarinic acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 29453275 DOI: 10.1073/Pnas.1718037115  0.433
2018 Livingston KE, Mahoney JP, Manglik A, Sunahara RK, Traynor JR. Author response: Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor Elife. DOI: 10.7554/Elife.32499.015  0.355
2017 Fish I, Stoessel A, Eitel K, Valant C, Albold S, Hübner H, Möller D, Clark MJ, Sunahara RK, Christopoulos A, Shoichet BK, Gmeiner P. Structure-based design and discovery of new M2 receptor agonists. Journal of Medicinal Chemistry. PMID 29094937 DOI: 10.1021/Acs.Jmedchem.7B01113  0.417
2017 Malik RU, Dysthe M, Ritt M, Sunahara RK, Sivaramakrishnan S. ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells. Scientific Reports. 7: 7749. PMID 28798477 DOI: 10.1038/S41598-017-08029-3  0.47
2017 O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS. Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK. Science Signaling. 10. PMID 28634209 DOI: 10.1126/Scisignal.Aal3395  0.351
2017 Cai Y, Liu Y, Culhane KJ, DeVree BT, Yang Y, Sunahara RK, Yan ECY. Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor. Plos One. 12: e0179568. PMID 28609478 DOI: 10.1371/Journal.Pone.0179568  0.806
2017 Brea RJ, Cole CM, Lyda BR, Ye L, Prosser RS, Sunahara RK, Devaraj NK. In Situ Reconstitution of the Adenosine A2A Receptor in Spontaneously Formed Synthetic Liposomes. Journal of the American Chemical Society. PMID 28263576 DOI: 10.1021/Jacs.6B12830  0.507
2016 Mahoney JP, Sunahara RK. Mechanistic insights into GPCR-G protein interactions. Current Opinion in Structural Biology. 41: 247-254. PMID 27871057 DOI: 10.1016/J.Sbi.2016.11.005  0.581
2016 Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, et al. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. PMID 27499021 DOI: 10.1016/J.Cell.2016.07.004  0.528
2016 DeVree BT, Mahoney JP, Vélez-Ruiz GA, Rasmussen SG, Kuszak AJ, Edwald E, Fung JJ, Manglik A, Masureel M, Du Y, Matt RA, Pardon E, Steyaert J, Kobilka BK, Sunahara RK. Allosteric coupling from G protein to the agonist-binding pocket in GPCRs. Nature. PMID 27362234 DOI: 10.1038/Nature18324  0.831
2016 Sunahara RK, Insel PA. The molecular pharmacology of G protein signaling then and now: A tribute to Alfred G. Gilman. Molecular Pharmacology. PMID 26984025 DOI: 10.1124/Mol.116.104216  0.466
2015 Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. Pharmacological chaperone for α-crystallin partially restores transparency in cataract models. Science (New York, N.Y.). 350: 674-7. PMID 26542570 DOI: 10.1126/Science.Aac9145  0.746
2015 Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE. SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. Science (New York, N.Y.). 348: 1361-5. PMID 26089515 DOI: 10.1126/Science.Aaa5264  0.497
2013 Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S. Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells. The Journal of Biological Chemistry. 288: 17167-78. PMID 23629648 DOI: 10.1074/Jbc.M113.464065  0.802
2013 Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 495: 534-8. PMID 23515162 DOI: 10.1038/Nature12000  0.533
2013 Chung KY, Day PW, Vélez-Ruiz G, Sunahara RK, Kobilka BK. Identification of GPCR-interacting cytosolic proteins using HDL particles and mass spectrometry-based proteomic approach. Plos One. 8: e54942. PMID 23372797 DOI: 10.1371/Journal.Pone.0054942  0.505
2013 Mitra N, Liu Y, Liu J, Serebryany E, Mooney V, DeVree BT, Sunahara RK, Yan EC. Calcium-dependent ligand binding and G-protein signaling of family B GPCR parathyroid hormone 1 receptor purified in nanodiscs. Acs Chemical Biology. 8: 617-25. PMID 23237450 DOI: 10.1021/Cb300466N  0.806
2012 Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature. 485: 321-6. PMID 22437502 DOI: 10.1038/Nature10954  0.457
2011 Chung KY, Rasmussen SG, Liu T, Li S, DeVree BT, Chae PS, Calinski D, Kobilka BK, Woods VL, Sunahara RK. Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature. 477: 611-5. PMID 21956331 DOI: 10.1038/Nature10488  0.835
2011 Westfield GH, Rasmussen SG, Su M, Dutta S, DeVree BT, Chung KY, Calinski D, Velez-Ruiz G, Oleskie AN, Pardon E, Chae PS, Liu T, Li S, Woods VL, Steyaert J, ... ... Sunahara RK, et al. Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 16086-91. PMID 21914848 DOI: 10.1073/Pnas.1113645108  0.804
2011 Vélez-Ruiz GA, Sunahara RK. Reconstitution of G protein-coupled receptors into a model bilayer system: reconstituted high-density lipoprotein particles. Methods in Molecular Biology (Clifton, N.J.). 756: 167-82. PMID 21870225 DOI: 10.1007/978-1-61779-160-4_8  0.385
2011 Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, ... ... Sunahara RK, et al. Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature. 477: 549-55. PMID 21772288 DOI: 10.1038/Nature10361  0.835
2011 Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, et al. Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature. 469: 236-40. PMID 21228876 DOI: 10.1038/Nature09665  0.833
2011 Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, et al. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature. 469: 175-80. PMID 21228869 DOI: 10.1038/Nature09648  0.824
2009 Fung JJ, Deupi X, Pardo L, Yao XJ, Velez-Ruiz GA, Devree BT, Sunahara RK, Kobilka BK. Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. The Embo Journal. 28: 3315-28. PMID 19763081 DOI: 10.1038/Emboj.2009.267  0.8
2009 Kuszak AJ, Pitchiaya S, Anand JP, Mosberg HI, Walter NG, Sunahara RK. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. The Journal of Biological Chemistry. 284: 26732-41. PMID 19542234 DOI: 10.1074/Jbc.M109.026922  0.534
2009 Yao XJ, Vélez Ruiz G, Whorton MR, Rasmussen SG, DeVree BT, Deupi X, Sunahara RK, Kobilka B. The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex. Proceedings of the National Academy of Sciences of the United States of America. 106: 9501-6. PMID 19470481 DOI: 10.1073/Pnas.0811437106  0.713
2009 Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, et al. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. The Journal of Pharmacology and Experimental Therapeutics. 329: 210-7. PMID 19136638 DOI: 10.1124/Jpet.108.144048  0.309
2008 Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK. Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. The Journal of Biological Chemistry. 283: 4387-94. PMID 18033822 DOI: 10.1074/Jbc.M703346200  0.789
2007 Cunliffe JM, Sunahara RK, Kennedy RT. Detection of g protein coupled receptor mediated adenylyl cyclase activity by capillary electrophoresis using fluorescently labeled ATP. Analytical Chemistry. 79: 7534-9. PMID 17718540 DOI: 10.1021/Ac071203+  0.523
2007 Cunliffe JM, Whorton MR, Sunahara RK, Kennedy RT. A CE assay for the detection of agonist-stimulated adenylyl cyclase activity. Electrophoresis. 28: 1913-20. PMID 17480040 DOI: 10.1002/Elps.200600571  0.786
2007 Whorton MR, Bokoch MP, Rasmussen SG, Huang B, Zare RN, Kobilka B, Sunahara RK. A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein. Proceedings of the National Academy of Sciences of the United States of America. 104: 7682-7. PMID 17452637 DOI: 10.1073/Pnas.0611448104  0.817
2007 Benson MD, Li QJ, Kieckhafer K, Dudek D, Whorton MR, Sunahara RK, Iñiguez-Lluhí JA, Martens JR. SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5. Proceedings of the National Academy of Sciences of the United States of America. 104: 1805-10. PMID 17261810 DOI: 10.1073/Pnas.0606702104  0.715
2007 Bodenstein J, Sunahara RK, Neubig RR. N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells. Molecular Pharmacology. 71: 1040-50. PMID 17220356 DOI: 10.1124/Mol.106.029397  0.44
2007 Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay. Molecular Pharmacology. 71: 169-75. PMID 17012620 DOI: 10.1124/Mol.106.028670  0.486
2006 Giguère P, Rochdi MD, Laroche G, Dupré E, Whorton MR, Sunahara RK, Claing A, Dupuis G, Parent JL. ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6. Cellular Signalling. 18: 1988-94. PMID 16650966 DOI: 10.1016/J.Cellsig.2006.03.003  0.772
2006 Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR. Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins. Chemical Biology & Drug Design. 67: 266-74. PMID 16629824 DOI: 10.1111/J.1747-0285.2006.00373.X  0.422
2006 Cunliffe JM, Sunahara RK, Kennedy RT. Detection of adenylyl cyclase activity using a fluorescent ATP substrate and capillary electrophoresis. Analytical Chemistry. 78: 1731-8. PMID 16536404 DOI: 10.1021/Ac0521201  0.322
2005 Morishima Y, Peng HM, Lin HL, Hollenberg PF, Sunahara RK, Osawa Y, Pratt WB. Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry. 44: 16333-40. PMID 16331994 DOI: 10.1021/Bi0515570  0.31
2005 Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. Journal of Lipid Research. 46: 1239-47. PMID 15772423 DOI: 10.1194/Jlr.M400511-Jlr200  0.301
2005 Vadakkadathmeethal K, Felczak A, Davignon I, Collins J, Sunahara RK. Cloning and characterization of the G protein betagamma subunits from Trichoplusia ni (High Five cells). Insect Biochemistry and Molecular Biology. 35: 333-45. PMID 15763469 DOI: 10.1016/J.Ibmb.2004.12.011  0.48
2005 Chang FJ, Lemme S, Sun Q, Sunahara RK, Beuve A. Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase Journal of Biological Chemistry. 280: 11513-11519. PMID 15649897 DOI: 10.1074/Jbc.M412203200  0.37
2005 Jameson EE, Roof RA, Whorton MH, Mosberg HI, Sunahara RK, Neubig RR, Kennedy RT. Real-time detection of basal and stimulated G protein GTPase activity using fluorescent GTP analogues Journal of Biological Chemistry. 280: 7712-7719. PMID 15613467 DOI: 10.1074/Jbc.M413810200  0.396
2004 Whelan RJ, Sunahara RK, Neubig RR, Kennedy RT. Affinity assays using fluorescence anisotropy with capillary electrophoresis separation. Analytical Chemistry. 76: 7380-6. PMID 15595883 DOI: 10.1021/Ac0489566  0.316
2004 Klein C, Heyduk T, Sunahara RK. Zinc inhibition of adenylyl cyclase correlates with conformational changes in the enzyme. Cellular Signalling. 16: 1177-85. PMID 15240012 DOI: 10.1016/J.Cellsig.2004.03.008  0.37
2004 Krumins AM, Barker SA, Huang C, Sunahara RK, Yu K, Wilkie TM, Gold SJ, Mumby SM. Differentially regulated expression of endogenous RGS4 and RGS7. The Journal of Biological Chemistry. 279: 2593-9. PMID 14604980 DOI: 10.1074/Jbc.M311600200  0.403
2003 Jameson EE, Cunliffe JM, Neubig RR, Sunahara RK, Kennedy RT. Detection of G proteins by affinity probe capillary electrophoresis using a fluorescently labeled GTP analogue Analytical Chemistry. 75: 4297-4304. PMID 14632149 DOI: 10.1021/Ac0342976  0.369
2003 Morishima Y, Kanelakis KC, Murphy PJ, Lowe ER, Jenkins GJ, Osawa Y, Sunahara RK, Pratt WB. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. The Journal of Biological Chemistry. 278: 48754-63. PMID 14507910 DOI: 10.1074/Jbc.M309814200  0.409
2003 Whorton MR, Sunahara RK. Adenylyl Cyclases Handbook of Cell Signaling. 2: 419-426. DOI: 10.1016/B978-012124546-7/50551-9  0.726
2002 Klein C, Sunahara RK, Hudson TY, Heyduk T, Howlett AC. Zinc inhibition of cAMP signaling. The Journal of Biological Chemistry. 277: 11859-65. PMID 11805091 DOI: 10.1074/Jbc.M108808200  0.558
2002 Tesmer JJ, Sunahara RK, Fancy DA, Gilman AG, Sprang SR. Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha. Methods in Enzymology. 345: 198-206. PMID 11665605 DOI: 10.1016/S0076-6879(02)45017-3  0.509
2002 Hatley ME, Gilman AG, Sunahara RK. Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases. Methods in Enzymology. 345: 127-40. PMID 11665600 DOI: 10.1016/S0076-6879(02)45012-4  0.592
2001 Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH, Taylor SS. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proceedings of the National Academy of Sciences of the United States of America. 98: 3220-5. PMID 11248059 DOI: 10.1073/Pnas.051633398  0.37
2000 Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR. Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry. 39: 14464-71. PMID 11087399 DOI: 10.1021/Bi0015562  0.7
2000 Hatley ME, Benton BK, Xu J, Manfredi JP, Gilman AG, Sunahara RK. Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase Journal of Biological Chemistry. 275: 38626-38632. PMID 10982815 DOI: 10.1074/Jbc.M007148200  0.621
2000 Ciliax BJ, Nash N, Heilman C, Sunahara R, Hartney A, Tiberi M, Rye DB, Caron MG, Niznik HB, Levey AI. Dopamine D(5) receptor immunolocalization in rat and monkey brain. Synapse (New York, N.Y.). 37: 125-45. PMID 10881034 DOI: 10.1002/1098-2396(200008)37:2<125::Aid-Syn7>3.0.Co;2-7  0.364
1999 Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR. Two-metal-Ion catalysis in adenylyl cyclase. Science (New York, N.Y.). 285: 756-60. PMID 10427002 DOI: 10.1126/Science.285.5428.756  0.559
1998 Sunahara RK, Beuve A, Tesmer JJ, Sprang SR, Garbers DL, Gilman AG. Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. The Journal of Biological Chemistry. 273: 16332-8. PMID 9632695 DOI: 10.1074/Jbc.273.26.16332  0.589
1997 Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science (New York, N.Y.). 278: 1907-16. PMID 9417641 DOI: 10.1126/Science.278.5345.1907  0.619
1997 Sunahara RK, Tesmer JJ, Gilman AG, Sprang SR. Crystal structure of the adenylyl cyclase activator Gsalpha. Science (New York, N.Y.). 278: 1943-7. PMID 9395396 DOI: 10.1126/Science.278.5345.1943  0.663
1997 Svenningsson P, Le Moine C, Kull B, Sunahara R, Bloch B, Fredholm BB. Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience. 80: 1171-85. PMID 9284069 DOI: 10.1016/S0306-4522(97)00180-2  0.327
1997 Sunahara RK, Dessauer CW, Whisnant RE, Kleuss C, Gilman AG. Interaction of G(sα) with the cytosolic domains of mammalian adenylyl cyclase Journal of Biological Chemistry. 272: 22265-22271. PMID 9268375 DOI: 10.1074/Jbc.272.35.22265  0.734
1996 Sunahara RK, Dessauer CW, Gilman AG. Complexity and diversity of mammalian adenylyl cyclases Annual Review of Pharmacology and Toxicology. 36: 461-480. PMID 8725398 DOI: 10.1146/Annurev.Pa.36.040196.002333  0.775
1994 Seeman P, Sunahara RK, Niznik HB. Receptor-receptor link in membranes revealed by ligand competition: example for dopamine D1 and D2 receptors. Synapse (New York, N.Y.). 17: 62-4. PMID 8042146 DOI: 10.1002/Syn.890170107  0.413
1993 Ohara K, Ulpian C, Seeman P, Sunahara RK, Van Tol HHM, Niznik HB. Schizophrenia: Dopamine D1 receptor sequence is normal, but has DNA polymorphisms Neuropsychopharmacology. 8: 131-135. PMID 8471124 DOI: 10.1038/Npp.1993.14  0.316
1993 Gelernter J, Kennedy JL, Grandy DK, Zhou QY, Civelli O, Pauls DL, Pakstis A, Kurlan R, Sunahara RK, Niznik HB. Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor. The American Journal of Psychiatry. 150: 449-53. PMID 8434661 DOI: 10.1176/Ajp.150.3.449  0.308
1993 Levey AI, Hersch SM, Rye DB, Sunahara RK, Niznik HB, Kitt CA, Price DL, Maggio R, Brann MR, Ciliax BJ. Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. Proceedings of the National Academy of Sciences of the United States of America. 90: 8861-5. PMID 8415621 DOI: 10.1073/Pnas.90.19.8861  0.33
1993 Sugamori KS, Sunahara RK, Guan HC, Bulloch AG, Tensen CP, Seeman P, Niznik HB, Van Tol HH. Serotonin receptor cDNA cloned from Lymnaea stagnalis. Proceedings of the National Academy of Sciences of the United States of America. 90: 11-5. PMID 8093556 DOI: 10.1073/Pnas.90.1.11  0.367
1993 Sunahara RK, Seeman P, Tol HHMV, Niznik HB. Dopamine Receptors and Antipsychotic Drug Response British Journal of Psychiatry. 163: 31-38. DOI: 10.1192/S000712500029257X  0.382
1992 Mengod G, Villaró MT, Landwehrmeyer GB, Martinez-Mir MI, Niznik HB, Sunahara RK, Seeman P, O'Dowd BF, Probst A, Palacios JM. Visualization of dopamine D1, D2 and D3 receptor mRNAs in human and rat brain. Neurochemistry International. 20: 33S-43S. PMID 1365451 DOI: 10.1016/0197-0186(92)90208-9  0.312
1992 Seeman P, Guan HC, Civelli O, Van Tol HH, Sunahara RK, Niznik HB. The cloned dopamine D2 receptor reveals different densities for dopamine receptor antagonist ligands. Implications for human brain positron emission tomography. European Journal of Pharmacology. 227: 139-46. PMID 1358662 DOI: 10.1016/0922-4106(92)90121-B  0.362
1992 Demchyshyn L, Sunahara RK, Miller K, Teitler M, Hoffman BJ, Kennedy JL, Seeman P, Van Tol HH, Niznik HB. A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6. Proceedings of the National Academy of Sciences of the United States of America. 89: 5522-6. PMID 1351684 DOI: 10.1073/Pnas.89.12.5522  0.442
1991 Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature. 350: 610-4. PMID 1840645 DOI: 10.1038/350610A0  0.391
1991 Sunahara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HHM, Niznik HB. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1 Nature. 350: 614-619. PMID 1826762 DOI: 10.1038/350614A0  0.412
1991 Mengod G, Vilaró MT, Niznik HB, Sunahara RK, Seeman P, O'Dowd BF, Palacios JM. Visualization of a dopamine D1 receptor mRNA in human and rat brain. Brain Research. Molecular Brain Research. 10: 185-91. PMID 1649371 DOI: 10.1016/0169-328X(91)90110-J  0.333
1990 Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL, Israel Y. Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature. 347: 80-3. PMID 1975640 DOI: 10.1038/347080A0  0.435
Low-probability matches (unlikely to be authored by this person)
2012 Lee TY, Park YS, Garcia GA, Sunahara RK, Woods JH, Yang VC. Cell permeable cocaine esterases constructed by chemical conjugation and genetic recombination. Molecular Pharmaceutics. 9: 1361-73. PMID 22404344 DOI: 10.1021/Mp200623W  0.3
2022 Kwon Y, Mehta S, Clark M, Walters G, Zhong Y, Lee HN, Sunahara RK, Zhang J. Non-canonical β-adrenergic activation of ERK at endosomes. Nature. PMID 36289326 DOI: 10.1038/s41586-022-05343-3  0.297
2011 Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J, Ko MC, Woods JH, Tesmer JJ, Sunahara RK. Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time. Molecular Pharmacology. 80: 1056-65. PMID 21890748 DOI: 10.1124/Mol.111.074997  0.292
2007 Vadakkadathmeethal K, Cunliffe JM, Swift J, Kennedy RT, Neubig RR, Sunahara RK. Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening. Combinatorial Chemistry & High Throughput Screening. 10: 289-98. PMID 17506713 DOI: 10.2174/138620707780636600  0.291
2018 Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, et al. Publisher Correction: Structural insights into binding specificity, efficacy and bias of a βAR partial agonist. Nature Chemical Biology. PMID 30504785 DOI: 10.1038/S41589-018-0182-5  0.289
2015 Mallik L, Dhakal S, Nichols J, Mahoney J, Dosey AM, Jiang S, Sunahara RK, Skiniotis G, Walter NG. Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami. Acs Nano. PMID 26149412 DOI: 10.1021/Acsnano.5B01841  0.287
2020 Xu X, Kaindl J, Clark MJ, Hübner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X. Binding pathway determines norepinephrine selectivity for the human βAR over βAR. Cell Research. PMID 33093660 DOI: 10.1038/s41422-020-00424-2  0.285
2010 Kuszak AJ, Yao XJ, Rasmussen SGF, Kobilka BK, Sunahara RK. Functional studies of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein particles G Protein-Coupled Receptors: Structure, Signaling, and Physiology. 32-52. DOI: 10.1017/CBO9780511760334.003  0.273
2019 Copits B, O'Neill P, Parker K, Yoo J, Vasquez A, Samineni V, Stander C, Sunahara R, Gereau R, Bruchas M. (344) A Photoswitchable GPCR-Based Opsin for Synaptic Inhibition The Journal of Pain. 20: S60-S61. DOI: 10.1016/J.Jpain.2019.02.040  0.272
2010 Park JB, Kwon YM, Lee TY, Brim R, Ko MC, Sunahara RK, Woods JH, Yang VC. PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity. Journal of Controlled Release : Official Journal of the Controlled Release Society. 142: 174-9. PMID 19857534 DOI: 10.1016/J.Jconrel.2009.10.015  0.271
1997 Durante W, Christodoulides N, Cheng K, Peyton KJ, Sunahara RK, Schafer AI. cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle. The American Journal of Physiology. 273: H317-23. PMID 9249506 DOI: 10.1152/Ajpheart.1997.273.1.H317  0.27
2010 Narasimhan D, Nance MR, Gao D, Ko MC, Macdonald J, Tamburi P, Yoon D, Landry DM, Woods JH, Zhan CG, Tesmer JJ, Sunahara RK. Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Engineering, Design & Selection : Peds. 23: 537-47. PMID 20436035 DOI: 10.1093/Protein/Gzq025  0.267
1995 Durante W, Cheng K, Sunahara RK, Schafer AI. Ethanol potentiates interleukin-1 beta-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells. The Biochemical Journal. 231-6. PMID 7538755 DOI: 10.1042/Bj3080231  0.267
2011 Brim RL, Noon KR, Nichols J, Narasimhan D, Woods JH, Sunahara RK. Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs. Drug and Alcohol Dependence. 119: 224-8. PMID 21775073 DOI: 10.1016/J.Drugalcdep.2011.06.018  0.264
2002 Sunahara RK, Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Molecular Interventions. 2: 168-84. PMID 14993377 DOI: 10.1124/Mi.2.3.168  0.264
1991 Weiner DM, Levey AI, Sunahara RK, Niznik HB, O'Dowd BF, Seeman P, Brann MR. D1 and D2 dopamine receptor mRNA in rat brain. Proceedings of the National Academy of Sciences of the United States of America. 88: 1859-63. PMID 1825729 DOI: 10.1073/Pnas.88.5.1859  0.264
2012 Narasimhan D, Woods JH, Sunahara RK. Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction. Future Medicinal Chemistry. 4: 137-50. PMID 22300094 DOI: 10.4155/Fmc.11.194  0.258
2020 Kwon Y, Clark MJ, Keyes J, Walters G, Sunahara RK, Zhang J. Spatiotemporal Control of ERK Activity by b 2 ‐adrenergic Signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07537  0.254
1991 Nguyen T, Sunahara R, Marchese A, Van Tol HH, Seeman P, O'Dowd BF. Transcription of a human dopamine D5 pseudogene. Biochemical and Biophysical Research Communications. 181: 16-21. PMID 1958184 DOI: 10.1016/S0006-291X(05)81375-0  0.253
2010 Brim RL, Nance MR, Youngstrom DW, Narasimhan D, Zhan CG, Tesmer JJ, Sunahara RK, Woods JH. A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Molecular Pharmacology. 77: 593-600. PMID 20086035 DOI: 10.1124/Mol.109.060806  0.247
2012 Collins GT, Narasimhan D, Cunningham AR, Zaks ME, Nichols J, Ko MC, Sunahara RK, Woods JH. Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1092-103. PMID 21993206 DOI: 10.1038/Npp.2011.226  0.245
2009 Gao D, Narasimhan DL, Macdonald J, Brim R, Ko MC, Landry DW, Woods JH, Sunahara RK, Zhan CG. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Molecular Pharmacology. 75: 318-23. PMID 18987161 DOI: 10.1124/Mol.108.049486  0.245
2012 Brim RL, Noon KR, Collins GT, Stein A, Nichols J, Narasimhan D, Ko MC, Woods JH, Sunahara RK. The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination. The Journal of Pharmacology and Experimental Therapeutics. 340: 83-95. PMID 21990608 DOI: 10.1124/Jpet.111.186049  0.24
2006 Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Molecular Pharmacology. 70: 1885-91. PMID 16968810 DOI: 10.1124/Mol.106.025999  0.239
2009 Collins GT, Brim RL, Narasimhan D, Ko MC, Sunahara RK, Zhan CG, Woods JH. Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats. The Journal of Pharmacology and Experimental Therapeutics. 331: 445-55. PMID 19710369 DOI: 10.1124/Jpet.108.150029  0.237
2011 Collins GT, Carey KA, Narasimhan D, Nichols J, Berlin AA, Lukacs NW, Sunahara RK, Woods JH, Ko MC. Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1047-59. PMID 21289605 DOI: 10.1038/Npp.2010.242  0.23
2011 Brim RL, Noon KR, Collins GT, Nichols J, Narasimhan D, Sunahara RK, Woods JH. The ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometry. Molecular Pharmacology. 80: 1119-27. PMID 21885621 DOI: 10.1124/Mol.111.074534  0.229
2012 Collins GT, Brim RL, Noon KR, Narasimhan D, Lukacs NW, Sunahara RK, Woods JH, Ko MC. Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 342: 205-13. PMID 22518021 DOI: 10.1124/Jpet.112.194639  0.227
2009 Jutkiewicz EM, Baladi MG, Cooper ZD, Narasimhan D, Sunahara RK, Woods JH. A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. Annals of Emergency Medicine. 54: 409-20. PMID 19013687 DOI: 10.1016/J.Annemergmed.2008.09.023  0.227
2007 Ko MC, Bowen LD, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Cooper ZD, Woods JH. Cocaine esterase: interactions with cocaine and immune responses in mice. The Journal of Pharmacology and Experimental Therapeutics. 320: 926-33. PMID 17114567 DOI: 10.1124/Jpet.106.114223  0.226
2011 Collins GT, Zaks ME, Cunningham AR, St Clair C, Nichols J, Narasimhan D, Ko MC, Sunahara RK, Woods JH. Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats. Drug and Alcohol Dependence. 118: 158-65. PMID 21481548 DOI: 10.1016/J.Drugalcdep.2011.03.015  0.224
2009 Ko MC, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Woods JH. Effects of cocaine esterase following its repeated administration with cocaine in mice. Drug and Alcohol Dependence. 101: 202-9. PMID 19217723 DOI: 10.1016/J.Drugalcdep.2009.01.002  0.221
2010 Wood SK, Narasimhan D, Cooper Z, Sunahara RK, Woods JH. Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats. Drug and Alcohol Dependence. 106: 219-29. PMID 19800183 DOI: 10.1016/J.Drugalcdep.2009.09.001  0.22
2007 Roman DL, Talbot JN, Roof RA, Sunahara RK, Traynor JR, Neubig RR. Characterization and mechanistic investigation of CCG‐4986, a small molecule RGS4 inhibitor The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A431  0.216
2014 Howell LL, Nye JA, Stehouwer JS, Voll RJ, Mun J, Narasimhan D, Nichols J, Sunahara R, Goodman MM, Carroll FI, Woods JH. A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates. Translational Psychiatry. 4: e407. PMID 24984194 DOI: 10.1038/Tp.2014.48  0.214
1990 Sunahara RK, Murphy BJ, Tuana BS. A sensitive and rapid method for identification and characterization of low abundance receptors. Analytical Biochemistry. 185: 143-6. PMID 2160777 DOI: 10.1016/0003-2697(90)90269-F  0.21
2007 Walter NG, Meiners JC, Meyhofer E, Neubig RR, Sunahara RK, Perkins NC, Steel DG, Swanson JA. Under the microscope: single molecule symposium at the University of Michigan, 2006. Biopolymers. 85: 106-14. PMID 17080420 DOI: 10.1002/Bip.20621  0.208
2014 Howell L, Nye J, Stehouwer J, Voll R, Mun J, Narasimhan D, Nichols J, Sunahara R, Goodman M, Carroll F, Woods J. Effects of a mutant bacterial cocaine esterase on cocaine brain levels measured with pet neuroimaging in rhesus monkeys Drug and Alcohol Dependence. 140: e92-e93. DOI: 10.1016/J.Drugalcdep.2014.02.269  0.202
1991 Tuana BS, Sunahara RK, Murphy BJ, Pierce GN. Two major antigens of heart sarcolemma are Ca2(+)-binding glycoproteins that copurify with the dihydropyridine receptor. Biochimica Et Biophysica Acta. 1091: 236-41. PMID 1847306 DOI: 10.1016/0167-4889(91)90067-8  0.181
2021 Paggi JM, Belk JA, Hollingsworth SA, Villanueva N, Powers AS, Clark MJ, Chemparathy AG, Tynan JE, Lau TK, Sunahara RK, Dror RO. Leveraging nonstructural data to predict structures and affinities of protein-ligand complexes. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34921117 DOI: 10.1073/pnas.2112621118  0.18
2021 Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, Shirley SE, Ma KKL, Vasquez AM, Stander MC, ... ... Sunahara RK, et al. A photoswitchable GPCR-based opsin for presynaptic inhibition. Neuron. PMID 33979635 DOI: 10.1016/j.neuron.2021.04.026  0.178
2021 Wheeler EC, Vora S, Mayer D, Kotini AG, Olszewska M, Park SS, Guccione E, Teruya-Feldstein J, Silverman L, Sunahara RK, Yeo GW, Papapetrou EP. Integrative RNA-omics discovers GNAS alternative splicing as a phenotypic driver of splicing factor-mutant neoplasms. Cancer Discovery. PMID 34620690 DOI: 10.1158/2159-8290.CD-21-0508  0.151
2023 Xu X, Shonberg J, Kaindl J, Clark MJ, Stößel A, Maul L, Mayer D, Hübner H, Hirata K, Venkatakrishnan AJ, Dror RO, Kobilka BK, Sunahara RK, Liu X, Gmeiner P. Author Correction: Constrained catecholamines gain βAR selectivity through allosteric effects on pocket dynamics. Nature Communications. 14: 2992. PMID 37225685 DOI: 10.1038/s41467-023-38820-y  0.07
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