| Year |
Citation |
Score |
| 2024 |
Patterson AR, Needle GA, Sugiura A, Jennings EQ, Chi C, Steiner KK, Fisher EL, Robertson GL, Bodnya C, Markle JG, Sheldon RD, Jones RG, Gama V, Rathmell JC. Functional overlap of inborn errors of immunity and metabolism genes defines T cell metabolic vulnerabilities. Science Immunology. 9: eadh0368. PMID 39151020 DOI: 10.1126/sciimmunol.adh0368 |
0.331 |
|
| 2024 |
Steiner KK, Young AC, Patterson AR, Jennings EQ, Chi C, Hatem Z, Heintzman D, Sugiura A, Arner EN, Sewell AE, Madden MZ, Okparaugo R, Fallman EV, Gibson-Corley K, Voss K, ... ... Rathmell J, et al. Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism. Biorxiv : the Preprint Server For Biology. PMID 39026793 DOI: 10.1101/2024.07.08.602554 |
0.37 |
|
| 2024 |
Rodriguez-Garcia GJ, Graves DK, Mirza MB, Idrees K, Kim YJ, Korrer MJ, Rathmell JC. Cancer Cell Small Molecule Secretome Induces the Immune Checkpoint NKG2A and Dysfunction of Human CD8+ T Cells. Immunohorizons. 8: 464-477. PMID 38922288 DOI: 10.4049/immunohorizons.2400046 |
0.33 |
|
| 2024 |
De Martino M, Rathmell JC, Galluzzi L, Vanpouille-Box C. Cancer cell metabolism and antitumour immunity. Nature Reviews. Immunology. PMID 38649722 DOI: 10.1038/s41577-024-01026-4 |
0.328 |
|
| 2024 |
Hathaway ES, Jennings EQ, Rathmell JC. Immunometabolic Maladaptations to the Tumor Microenvironment. Cold Spring Harbor Perspectives in Medicine. PMID 38438220 DOI: 10.1101/cshperspect.a041547 |
0.336 |
|
| 2024 |
Monteith AJ, Ramsey HE, Silver AJ, Brown D, Greenwood D, Smith BN, Wise AD, Liu J, Olmstead SD, Watke J, Arrate MP, Gorska AE, Fuller L, Locasale JW, Stubbs MC, ... Rathmell JC, et al. Lactate utilization enables metabolic escape to confer resistance to BET inhibition in acute myeloid leukemia. Cancer Research. PMID 38285895 DOI: 10.1158/0008-5472.CAN-23-0291 |
0.305 |
|
| 2023 |
Bacigalupa ZA, Landis MD, Rathmell JC. Nutrient inputs and social metabolic control of T cell fate. Cell Metabolism. 36: 10-20. PMID 38118440 DOI: 10.1016/j.cmet.2023.12.009 |
0.411 |
|
| 2023 |
Brookens SK, Cho SH, Paik Y, Meyer K, Raybuck AL, Park C, Greenwood DL, Rathmell JC, Boothby MR. Plasma Cell Differentiation, Antibody Quality, and Initial Germinal Center B Cell Population Depend on Glucose Influx Rate. Journal of Immunology (Baltimore, Md. : 1950). PMID 37955416 DOI: 10.4049/jimmunol.2200756 |
0.461 |
|
| 2023 |
Fu H, Vuononvirta J, Fanti S, Bonacina F, D'Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi MP, Grevitt P, ... ... Rathmell JC, et al. The glucose transporter 2 regulates CD8 T cell function via environment sensing. Nature Metabolism. PMID 37884694 DOI: 10.1038/s42255-023-00913-9 |
0.514 |
|
| 2023 |
Brookens SK, Cho SH, Paik Y, Meyer K, Raybuck AL, Park C, Greenwood DL, Rathmell JC, Boothby MR. Plasma cell differentiation, antibody quality, and initial germinal center B cell population depend on glucose influx rate. Biorxiv : the Preprint Server For Biology. PMID 37745429 DOI: 10.1101/2023.09.13.557599 |
0.457 |
|
| 2023 |
Sugiura A, Beier KL, Chi C, Heintzman DR, Ye X, Wolf MM, Patterson AR, Cephus JY, Hong HS, Lyssiotis CA, Newcomb DC, Rathmell JC. Tissue-Specific Dependence of Th1 Cells on the Amino Acid Transporter SLC38A1 in Inflammation. Biorxiv : the Preprint Server For Biology. PMID 37745344 DOI: 10.1101/2023.09.13.557496 |
0.304 |
|
| 2023 |
Madden MZ, Ye X, Chi C, Fisher EL, Wolf MM, Needle GA, Bader JE, Patterson AR, Reinfeld BI, Landis MD, Hathaway ES, Muka JE, O'Neil RT, Karijolich J, Philip M, ... Rathmell JC, et al. Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 37341499 DOI: 10.4049/jimmunol.2200715 |
0.413 |
|
| 2023 |
Gong M, Choi SC, Park YP, Zou X, Elshikha AS, Gerriets VA, Rathmell JC, Mohamazadeh M, Morel L. Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice. Iscience. 26: 106774. PMID 37216123 DOI: 10.1016/j.isci.2023.106774 |
0.383 |
|
| 2023 |
Arner EN, Rathmell JC. Metabolic programming and immune suppression in the tumor microenvironment. Cancer Cell. 41: 421-433. PMID 36801000 DOI: 10.1016/j.ccell.2023.01.009 |
0.37 |
|
| 2023 |
Patterson AR, Needle GA, Sugiura A, Chi C, Steiner KK, Fisher EL, Robertson GL, Bodnya C, Markle JG, Gama V, Rathmell JC. Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities. Biorxiv : the Preprint Server For Biology. PMID 36747715 DOI: 10.1101/2023.01.24.525419 |
0.323 |
|
| 2022 |
Song W, Postoak JL, Yang G, Guo X, Pua HH, Bader J, Rathmell JC, Kobayashi H, Haase VH, Leaptrot KL, Schrimpe-Rutledge AC, Sherrod SD, McLean JA, Zhang J, Wu L, et al. Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. Proceedings of the National Academy of Sciences of the United States of America. 120: e2214874120. PMID 36574710 DOI: 10.1073/pnas.2214874120 |
0.312 |
|
| 2022 |
Greenwood DL, Ramsey HE, Nguyen PTT, Patterson AR, Voss K, Bader JE, Sugiura A, Bacigalupa ZA, Schaefer S, Ye X, Dahunsi DO, Madden MZ, Wellen KE, Savona MR, Ferrell PB, ... Rathmell JC, et al. Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk. Immunohorizons. 6: 837-850. PMID 36547387 DOI: 10.4049/immunohorizons.2200086 |
0.364 |
|
| 2022 |
Kaviany S, Bartkowiak T, Dulek DE, Khan YW, Hayes MJ, Schaefer SG, Ye X, Dahunsi DO, Connelly JA, Irish JM, Rathmell JC. Systems Immunology Analyses of Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1. Immunohorizons. 6: 447-464. PMID 35840326 DOI: 10.4049/immunohorizons.2200041 |
0.366 |
|
| 2022 |
Chen Z, Simon-Molas H, Cretenet G, Valle-Argos B, Smith LD, Forconi F, Schomakers BV, van Weeghel M, Bryant D, van Bruggen JAC, Peters FS, Rathmell JC, van der Windt GJW, Kater AP, Packham G, et al. Characterization of metabolic alterations of Chronic Lymphocytic Leukemia in the lymph node microenvironment. Blood. PMID 35486832 DOI: 10.1182/blood.2021013990 |
0.435 |
|
| 2022 |
Huang Y, Zou Y, Jiao Y, Shi P, Nie X, Huang W, Xiong C, Choi M, Huang C, Macintyre AN, Nichols A, Li F, Li CY, MacIver NJ, Cardona DM, ... ... Rathmell JC, et al. Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft--Host Disease While Preserving Graft-Versus-Leukemia Effect. Frontiers in Immunology. 13: 751296. PMID 35296079 DOI: 10.3389/fimmu.2022.751296 |
0.386 |
|
| 2022 |
Heintzman DR, Fisher EL, Rathmell JC. Microenvironmental influences on T cell immunity in cancer and inflammation. Cellular & Molecular Immunology. 19: 316-326. PMID 35039633 DOI: 10.1038/s41423-021-00833-2 |
0.355 |
|
| 2021 |
Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, ... ... Rathmell JC, et al. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. PMID 34767747 DOI: 10.1016/j.immuni.2021.10.011 |
0.44 |
|
| 2021 |
Mohamed FA, Thangavelu G, Rhee SY, Sage PT, O'Connor RS, Rathmell JC, Blazar BR. Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease. Frontiers in Immunology. 12: 757836. PMID 34712243 DOI: 10.3389/fimmu.2021.757836 |
0.352 |
|
| 2021 |
Reinfeld BI, Rathmell WK, Kim TK, Rathmell JC. The therapeutic implications of immunosuppressive tumor aerobic glycolysis. Cellular & Molecular Immunology. PMID 34239083 DOI: 10.1038/s41423-021-00727-3 |
0.332 |
|
| 2021 |
Voss K, Hong HS, Bader JE, Sugiura A, Lyssiotis CA, Rathmell JC. A guide to interrogating immunometabolism. Nature Reviews. Immunology. PMID 33859379 DOI: 10.1038/s41577-021-00529-8 |
0.319 |
|
| 2021 |
Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, ... ... Rathmell JC, et al. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature. PMID 33828302 DOI: 10.1038/s41586-021-03442-1 |
0.766 |
|
| 2021 |
Madden MZ, Rathmell JC. The Complex Integration of T-cell Metabolism and Immunotherapy. Cancer Discovery. PMID 33795235 DOI: 10.1158/2159-8290.CD-20-0569 |
0.369 |
|
| 2021 |
Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8 T cells during the primary immune response. Immunity. PMID 33705706 DOI: 10.1016/j.immuni.2021.02.018 |
0.409 |
|
| 2021 |
Contreras Healey DC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, ... ... Rathmell JC, et al. Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. Journal of Immunology (Baltimore, Md. : 1950). PMID 33558372 DOI: 10.4049/jimmunol.2001029 |
0.452 |
|
| 2020 |
Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer. The Journal of Clinical Investigation. PMID 33320840 DOI: 10.1172/JCI140100 |
0.358 |
|
| 2020 |
Beckermann KE, Hongo R, Ye X, Young K, Carbonell K, Healey DCC, Siska PJ, Barone S, Roe CE, Smith CC, Vincent BG, Mason FM, Irish JM, Rathmell WK, Rathmell JC. CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation. Jci Insight. 5. PMID 32814710 DOI: 10.1172/Jci.Insight.138729 |
0.328 |
|
| 2020 |
Contat C, Ancey PB, Zangger N, Sabatino S, Pascual J, Escrig S, Jensen L, Goepfert C, Lanz B, Lepore M, Gruetter R, Rossier A, Berezowska S, Neppl C, Zlobec I, ... ... Rathmell JC, et al. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. Elife. 9. PMID 32571479 DOI: 10.7554/Elife.53618 |
0.368 |
|
| 2020 |
Lim AR, Rathmell WK, Rathmell JC. The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy. Elife. 9. PMID 32367803 DOI: 10.7554/Elife.55185 |
0.383 |
|
| 2020 |
Makowski L, Chaib M, Rathmell JC. Immunometabolism: From basic mechanisms to translation. Immunological Reviews. 295: 5-14. PMID 32320073 DOI: 10.1111/imr.12858 |
0.375 |
|
| 2020 |
Beckermann K, Young K, Hongo R, Ye X, Contreras D, Barone S, Roe CE, Smith CC, Vincent BG, Irish JM, Rathmell WK, Rathmell JC. Targeting metabolic dysregulation of T cells in kidney cancer. Journal of Clinical Oncology. 38: 722-722. DOI: 10.1200/Jco.2020.38.6_Suppl.722 |
0.403 |
|
| 2019 |
Li C, Zhu B, Son YM, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins JW, Siska PJ, Vincent BG, Prakash YS, Peikert T, Edelson BT, ... ... Rathmell JC, et al. The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8 T Cell Fitness and Functionality. Immunity. 51: 491-507.e7. PMID 31533057 DOI: 10.1016/J.Immuni.2019.08.013 |
0.337 |
|
| 2019 |
van Bruggen JAC, Martens AWJ, Fraietta JA, Hofland T, Tonino SH, Eldering E, Levin MD, Siska PJ, Endstra S, Rathmell JC, June CH, Porter DL, Melenhorst JJ, Kater AP, van der Windt GJW. Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T cell efficacy. Blood. PMID 31076448 DOI: 10.1182/Blood.2018885863 |
0.322 |
|
| 2019 |
Sinclair LV, Howden AJ, Brenes A, Spinelli L, Hukelmann JL, Macintyre AN, Liu X, Thomson S, Taylor PM, Rathmell JC, Locasale JW, Lamond AI, Cantrell DA. Antigen receptor control of methionine metabolism in T cells. Elife. 8. PMID 30916644 DOI: 10.7554/Elife.44210 |
0.328 |
|
| 2019 |
Chen Z, Cretenet G, ter Burg H, Andrejeva G, Rathmell JC, Forconi F, van der Windt GJW, Kater AP, Eldering E. Linking Microenvironmental Signals to Metabolic Switches and Drug Responses in Chronic Lymphocytic Leukemia Blood. 134: 479-479. DOI: 10.1182/blood-2019-123005 |
0.406 |
|
| 2018 |
Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature. PMID 30464343 DOI: 10.1038/S41586-018-0735-5 |
0.396 |
|
| 2018 |
Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, ... ... Rathmell JC, et al. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. Cell. PMID 30392958 DOI: 10.1016/J.Cell.2018.10.001 |
0.368 |
|
| 2018 |
Chatterjee S, Chakraborty P, Daenthanasanmak A, Iamsawat S, Andrejeva G, A Luevano L, Wolf MM, Baliga UK, Krieg C, Beeson C, Mehrotra M, Hill EG, Rathmell JC, Yu XZ, Kraft AS, et al. Targeting PIM Kinase with PD1 inhibition Improves Immunotherapeutic Anti-Tumor T Cell Response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30327305 DOI: 10.1158/1078-0432.Ccr-18-0706 |
0.307 |
|
| 2018 |
Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP. xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression. Oncogene. PMID 29789716 DOI: 10.1038/S41388-018-0307-Z |
0.356 |
|
| 2018 |
Zhang Z, Zi Z, Lee EE, Zhao J, Contreras DC, South AP, Abel ED, Chong BF, Vandergriff T, Hosler GA, Scherer PE, Mettlen M, Rathmell JC, DeBerardinis RJ, Wang RC. Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. Nature Medicine. PMID 29662201 DOI: 10.1038/S41591-018-0003-0 |
0.434 |
|
| 2018 |
Chen YH, Kratchmarov R, Lin WW, Rothman NJ, Yen B, Adams WC, Nish SA, Rathmell JC, Reiner SL. Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway. Cell Reports. 22: 860-868. PMID 29420173 DOI: 10.1016/J.Celrep.2017.12.087 |
0.335 |
|
| 2018 |
Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nature Medicine. PMID 29334372 DOI: 10.1038/Nm.4464 |
0.358 |
|
| 2018 |
Sugiura A, Rathmell JC. Metabolic Barriers to T Cell Function in Tumors. Journal of Immunology (Baltimore, Md. : 1950). 200: 400-407. PMID 29311381 DOI: 10.4049/jimmunol.1701041 |
0.387 |
|
| 2018 |
Ramsey H, Zhang S, Zhao Y, Fischer MA, Gorska AE, Arrate M, Fuller L, Greenwood D, Stubbs MC, Liu P, Rathmell JC, Hiebert S, Savona MR. The BET Inhibitor INCB054329 Primes AML Cells for Venetoclax-Induced Apoptosis Blood. 132: 4074-4074. DOI: 10.1182/Blood-2018-99-111393 |
0.339 |
|
| 2018 |
Rathmell JC. T Cell Metabolism and Memory Blood. 132: SCI-6-SCI-6. DOI: 10.1182/blood-2018-99-109535 |
0.426 |
|
| 2017 |
Afzal J, Chan A, Karakas MF, Woldemichael K, Vakrou S, Guan Y, Rathmell J, Wahl R, Pomper M, Foster DB, Aon MA, Tsui B, O'Rourke B, Abraham MR. Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status. Jacc. Basic to Translational Science. 2: 543-560. PMID 29520378 DOI: 10.1016/J.Jacbts.2017.03.016 |
0.608 |
|
| 2017 |
MacIver NJ, Rathmell JC. Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate. Current Opinion in Immunology. PMID 28684058 DOI: 10.1016/j.coi.2017.06.002 |
0.393 |
|
| 2017 |
Andrejeva G, Rathmell JC. Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors. Cell Metabolism. 26: 49-70. PMID 28683294 DOI: 10.1016/j.cmet.2017.06.004 |
0.354 |
|
| 2017 |
Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, ... ... Rathmell JC, et al. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. Jci Insight. 2. PMID 28614802 DOI: 10.1172/Jci.Insight.93411 |
0.429 |
|
| 2017 |
Olenchock BA, Rathmell JC, Vander Heiden MG. Biochemical Underpinnings of Immune Cell Metabolic Phenotypes. Immunity. 46: 703-713. PMID 28514672 DOI: 10.1016/j.immuni.2017.04.013 |
0.304 |
|
| 2017 |
Beckermann KE, Dudzinski SO, Rathmell JC. Dysfunctional T cell metabolism in the tumor microenvironment. Cytokine & Growth Factor Reviews. PMID 28456467 DOI: 10.1016/j.cytogfr.2017.04.003 |
0.399 |
|
| 2017 |
Rhoads JP, Major AS, Rathmell JC. Fine tuning of immunometabolism for the treatment of rheumatic diseases. Nature Reviews. Rheumatology. PMID 28381829 DOI: 10.1038/nrrheum.2017.54 |
0.332 |
|
| 2017 |
Beckermann K, Siska P, Mason F, Rathmell K, Rathmell JC. Metabolic barriers to immunotherapy in renal cell carcinoma. Journal of Clinical Oncology. 35: 11560-11560. DOI: 10.1200/jco.2017.35.15_suppl.11560 |
0.392 |
|
| 2016 |
Adams WC, Chen YH, Kratchmarov R, Yen B, Nish SA, Lin WW, Rothman NJ, Luchsinger LL, Klein U, Busslinger M, Rathmell JC, Snoeck HW, Reiner SL. Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. Cell Reports. 17: 3142-3152. PMID 28009285 DOI: 10.1016/J.Celrep.2016.11.065 |
0.39 |
|
| 2016 |
Siska PJ, Rathmell JC. Metabolic Signaling Drives IFN-γ. Cell Metabolism. 24: 651-652. PMID 27829134 DOI: 10.1016/j.cmet.2016.10.018 |
0.305 |
|
| 2016 |
Johnson MO, Siska PJ, Contreras DC, Rathmell JC. Nutrients and the microenvironment to feed a T cell army. Seminars in Immunology. PMID 27712958 DOI: 10.1016/j.smim.2016.09.003 |
0.448 |
|
| 2016 |
Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, Warmoes MO, de Cubas AA, MacIver NJ, Locasale JW, Turka LA, Wells AD, Rathmell JC. Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nature Immunology. PMID 27695003 DOI: 10.1038/Ni.3577 |
0.502 |
|
| 2016 |
Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H. mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. Immunity. PMID 27637146 DOI: 10.1016/J.Immuni.2016.08.017 |
0.516 |
|
| 2016 |
Siska PJ, Kim B, Ji X, Hoeksema MD, Massion PP, Beckermann KE, Wu J, Chi JT, Hong J, Rathmell JC. Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes. Journal of Immunological Methods. PMID 27594594 DOI: 10.1016/J.Jim.2016.08.013 |
0.452 |
|
| 2016 |
Siska PJ, van der Windt GJ, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC. Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. Journal of Immunology (Baltimore, Md. : 1950). PMID 27511728 DOI: 10.4049/jimmunol.1502464 |
0.472 |
|
| 2016 |
O'Neill LA, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nature Reviews. Immunology. 16: 553-65. PMID 27396447 DOI: 10.1038/Nri.2016.70 |
0.399 |
|
| 2016 |
Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, ... ... Rathmell JC, et al. AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. Cell Metabolism. 23: 649-62. PMID 27076078 DOI: 10.1016/J.Cmet.2016.03.008 |
0.426 |
|
| 2016 |
Park S, Chang CY, Safi R, Liu X, Baldi R, Jasper JS, Anderson GR, Liu T, Rathmell JC, Dewhirst MW, Wood KC, Locasale JW, McDonnell DP. ERRα Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Reports. PMID 27050525 DOI: 10.1016/J.Celrep.2016.03.026 |
0.384 |
|
| 2016 |
Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Developmental Cell. 36: 540-9. PMID 26954548 DOI: 10.1016/j.devcel.2016.02.012 |
0.392 |
|
| 2016 |
McFadden K, Hafez AY, Kishton R, Messinger JE, Nikitin PA, Rathmell JC, Luftig MA. Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization. Proceedings of the National Academy of Sciences of the United States of America. PMID 26802124 DOI: 10.1073/Pnas.1517141113 |
0.482 |
|
| 2016 |
Johnson MO, Rathmell JC. AIF Is "Always In Fashion" for T Cells. Immunity. 44: 11-3. PMID 26789917 DOI: 10.1016/j.immuni.2015.12.015 |
0.444 |
|
| 2016 |
Jia W, Poe JC, Su H, Matsushima GK, Rathmell J, Imai K, Reyes NJ, Cardona DM, Anand S, Deoliveira D, Li Z, Saban DR, Chen BJ, Chao NJ, Sarantopoulos S. Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd Blood. 128: 498-498. DOI: 10.1182/Blood.V128.22.498.498 |
0.355 |
|
| 2015 |
Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, ... ... Rathmell JC, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002 |
0.353 |
|
| 2015 |
Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, et al. MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metabolism. 22: 1009-19. PMID 26387865 DOI: 10.1016/J.Cmet.2015.09.003 |
0.719 |
|
| 2015 |
Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, ... ... Rathmell JC, et al. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. Cell. PMID 26321681 DOI: 10.1016/J.Cell.2015.08.012 |
0.366 |
|
| 2015 |
Murray PJ, Rathmell J, Pearce E. SnapShot: Immunometabolism. Cell Metabolism. 22: 190-190.e1. PMID 26154058 DOI: 10.1016/j.cmet.2015.06.014 |
0.328 |
|
| 2015 |
Siska PJ, Rathmell JC. PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1. Molecular Cell. 58: 711-2. PMID 26046643 DOI: 10.1016/j.molcel.2015.05.025 |
0.44 |
|
| 2015 |
Kishton RJ, Rathmell JC. Novel therapeutic targets of tumor metabolism. Cancer Journal (Sudbury, Mass.). 21: 62-9. PMID 25815845 DOI: 10.1097/PPO.0000000000000099 |
0.376 |
|
| 2015 |
Siska PJ, Rathmell JC. T cell metabolic fitness in antitumor immunity. Trends in Immunology. 36: 257-64. PMID 25773310 DOI: 10.1016/j.it.2015.02.007 |
0.412 |
|
| 2015 |
Gerriets VA, Kishton RJ, Nichols AG, Macintyre AN, Inoue M, Ilkayeva O, Winter PS, Liu X, Priyadharshini B, Slawinska ME, Haeberli L, Huck C, Turka LA, Wood KC, Hale LP, ... ... Rathmell JC, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. The Journal of Clinical Investigation. 125: 194-207. PMID 25437876 DOI: 10.1172/Jci76012 |
0.374 |
|
| 2015 |
Stathem M, Marimuthu S, O'Neal J, Rathmell JC, Chesney JA, Beverly LJ, Siskind LJ. Glucose availability and glycolytic metabolism dictate glycosphingolipid levels. Journal of Cellular Biochemistry. 116: 67-80. PMID 25145677 DOI: 10.1002/Jcb.24943 |
0.499 |
|
| 2014 |
Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, et al. Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways Nature Immunology. 15: 996-996. PMID 25232822 DOI: 10.1038/Ni0910-996 |
0.378 |
|
| 2014 |
Cao Y, Rathmell JC, Macintyre AN. Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. Plos One. 9: e104104. PMID 25090630 DOI: 10.1371/journal.pone.0104104 |
0.357 |
|
| 2014 |
Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metabolism. 20: 61-72. PMID 24930970 DOI: 10.1016/J.Cmet.2014.05.004 |
0.53 |
|
| 2014 |
Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. Plos One. 9: e98705. PMID 24879016 DOI: 10.1371/Journal.Pone.0098705 |
0.756 |
|
| 2014 |
Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. Journal of Immunology (Baltimore, Md. : 1950). 192: 3626-36. PMID 24616478 DOI: 10.4049/Jimmunol.1302062 |
0.449 |
|
| 2014 |
Saucillo DC, Gerriets VA, Sheng J, Rathmell JC, Maciver NJ. Leptin metabolically licenses T cells for activation to link nutrition and immunity. Journal of Immunology (Baltimore, Md. : 1950). 192: 136-44. PMID 24273001 DOI: 10.4049/jimmunol.1301158 |
0.464 |
|
| 2014 |
Siska PJ, Weinberg JB, Rao AV, Bain JR, Muehlbauer MJ, Liu T, Rathmell J. Acute and Chronic Lymphocytic Leukemia Induces Exhaustion and Suppresses Metabolic Reprogramming in T Cell Activation Blood. 124: 4121-4121. DOI: 10.1182/Blood.V124.21.4121.4121 |
0.512 |
|
| 2014 |
Hsieh A, Altman B, Stine Z, Gouw A, Venkataraman A, Li B, Goraksha-Hicks P, Diskin S, Bellovin D, Celeste Simon M, Rathmell J, Lazar M, Maris J, Felsher D, Hogenesch J, et al. TM-06 * MYC AND MYCN DISRUPTION OF THE MOLECULAR CLOCK IN CANCER CELLS Neuro-Oncology. 16: v214-v214. DOI: 10.1093/Neuonc/Nou278.6 |
0.765 |
|
| 2013 |
Macintyre AN, Rathmell JC. Activated lymphocytes as a metabolic model for carcinogenesis. Cancer & Metabolism. 1: 5. PMID 24280044 DOI: 10.1186/2049-3002-1-5 |
0.454 |
|
| 2013 |
Green DR, Rathmell J. Sweet nothings: sensing of sugar metabolites controls T cell function. Cell Metabolism. 18: 7-8. PMID 23823473 DOI: 10.1016/J.Cmet.2013.06.009 |
0.493 |
|
| 2013 |
Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, et al. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nature Immunology. 14: 611-8. PMID 23644504 DOI: 10.1038/Ni.2607 |
0.427 |
|
| 2013 |
McCarthy SA, Mufson RA, Pearce EJ, Rathmell JC, Howcroft TK. Metabolic reprogramming of the immune response in the tumor microenvironment. Cancer Biology & Therapy. 14: 315-8. PMID 23358474 DOI: 10.4161/cbt.23616 |
0.304 |
|
| 2013 |
Kurokawa M, Ito T, Yang CS, Zhao C, Macintyre AN, Rizzieri DA, Rathmell JC, Deininger MW, Reya T, Kornbluth S. Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2300-5. PMID 23324740 DOI: 10.1073/Pnas.1206551110 |
0.363 |
|
| 2013 |
MacIver NJ, Michalek RD, Rathmell JC. Metabolic regulation of T lymphocytes. Annual Review of Immunology. 31: 259-83. PMID 23298210 DOI: 10.1146/annurev-immunol-032712-095956 |
0.44 |
|
| 2012 |
Caro-Maldonado A, Gerriets VA, Rathmell JC. Matched and mismatched metabolic fuels in lymphocyte function. Seminars in Immunology. 24: 405-13. PMID 23290889 DOI: 10.1016/j.smim.2012.12.002 |
0.384 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Rathmell JC, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.671 |
|
| 2012 |
Altman BJ, Rathmell JC. Metabolic stress in autophagy and cell death pathways. Cold Spring Harbor Perspectives in Biology. 4: a008763. PMID 22952396 DOI: 10.1101/Cshperspect.A008763 |
0.794 |
|
| 2012 |
Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, Damania B. Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 109: 11818-23. PMID 22752304 DOI: 10.1073/Pnas.1205995109 |
0.684 |
|
| 2012 |
Gerriets VA, Rathmell JC. Metabolic pathways in T cell fate and function. Trends in Immunology. 33: 168-73. PMID 22342741 DOI: 10.1016/j.it.2012.01.010 |
0.408 |
|
| 2012 |
Kim JS, Sklarz T, Waickman A, Li MO, Rathmell J, Birnbaum M, Powell J, Jordan MS, Koretzky GA. Akt and mTOR Pathways Differentially Regulate the Development of Natural and Inducible IL-17-Producing CD4+ T Cells Blood. 120: 838-838. DOI: 10.1182/Blood.V120.21.838.838 |
0.484 |
|
| 2012 |
Liu T, Weinberg JB, Davis ED, Volkheimer AD, Rathmell J. The Metabolic Signature of CLL: Enhanced Glucose Metabolism in A Subset of High-Risk CLL Patients Blood. 120: 1785-1785. DOI: 10.1182/Blood.V120.21.1785.1785 |
0.548 |
|
| 2011 |
Rathmell JC. T cell Myc-tabolism. Immunity. 35: 845-6. PMID 22195738 DOI: 10.1016/j.immuni.2011.12.001 |
0.408 |
|
| 2011 |
Michalek RD, Gerriets VA, Nichols AG, Inoue M, Kazmin D, Chang CY, Dwyer MA, Nelson ER, Pollizzi KN, Ilkayeva O, Giguere V, Zuercher WJ, Powell JD, Shinohara ML, McDonnell DP, ... Rathmell JC, et al. Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 108: 18348-53. PMID 22042850 DOI: 10.1073/Pnas.1108856108 |
0.532 |
|
| 2011 |
MacIver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG. The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. Journal of Immunology (Baltimore, Md. : 1950). 187: 4187-98. PMID 21930968 DOI: 10.4049/jimmunol.1100367 |
0.422 |
|
| 2011 |
Macintyre AN, Rathmell JC. PKM2 and the tricky balance of growth and energy in cancer. Molecular Cell. 42: 713-4. PMID 21700216 DOI: 10.1016/j.molcel.2011.06.003 |
0.322 |
|
| 2011 |
Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC. Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. Cancer Research. 71: 5204-13. PMID 21670080 DOI: 10.1158/0008-5472.Can-10-4531 |
0.837 |
|
| 2011 |
Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S. Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability. Molecular Biology of the Cell. 22: 1207-16. PMID 21325626 DOI: 10.1091/Mbc.E10-07-0567 |
0.678 |
|
| 2011 |
Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, Sullivan SA, Nichols AG, Rathmell JC. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. Journal of Immunology (Baltimore, Md. : 1950). 186: 3299-303. PMID 21317389 DOI: 10.4049/Jimmunol.1003613 |
0.822 |
|
| 2011 |
Wang X, Eno CO, Altman BJ, Zhu Y, Zhao G, Olberding KE, Rathmell JC, Li C. ER stress modulates cellular metabolism. The Biochemical Journal. 435: 285-96. PMID 21241252 DOI: 10.1042/Bj20101864 |
0.763 |
|
| 2011 |
Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. The Journal of Biological Chemistry. 286: 5921-33. PMID 21159778 DOI: 10.1074/Jbc.M110.179101 |
0.824 |
|
| 2011 |
Altman BJ, Jacobs SR, Mason EF, Michalek RD, MacIntyre AN, Coloff JL, Ilkayeva O, Jia W, He YW, Rathmell JC. Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. Oncogene. 30: 1855-67. PMID 21151168 DOI: 10.1038/Onc.2010.561 |
0.838 |
|
| 2011 |
Mason EF, Rathmell JC. Cell metabolism: an essential link between cell growth and apoptosis. Biochimica Et Biophysica Acta. 1813: 645-54. PMID 20816705 DOI: 10.1016/J.Bbamcr.2010.08.011 |
0.768 |
|
| 2010 |
Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Research. 70: 8066-76. PMID 20876800 DOI: 10.1158/0008-5472.Can-10-0608 |
0.849 |
|
| 2010 |
Michalek RD, Rathmell JC. The metabolic life and times of a T-cell. Immunological Reviews. 236: 190-202. PMID 20636818 DOI: 10.1111/j.1600-065X.2010.00911.x |
0.462 |
|
| 2010 |
Ke H, Harris R, Coloff JL, Jin JY, Leshin B, Miliani de Marval P, Tao S, Rathmell JC, Hall RP, Zhang JY. The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer Research. 70: 3080-8. PMID 20354187 DOI: 10.1158/0008-5472.Can-09-2923 |
0.711 |
|
| 2010 |
Jacobs SR, Michalek RD, Rathmell JC. IL-7 is essential for homeostatic control of T cell metabolism in vivo. Journal of Immunology (Baltimore, Md. : 1950). 184: 3461-9. PMID 20194717 DOI: 10.4049/Jimmunol.0902593 |
0.749 |
|
| 2010 |
Calamito M, Juntilla MM, Thomas M, Northrup DL, Rathmell J, Birnbaum MJ, Koretzky G, Allman D. Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood. 115: 4043-50. PMID 20042722 DOI: 10.1182/Blood-2009-09-241638 |
0.428 |
|
| 2009 |
Goraksha-Hicks P, Rathmell JC. TGF-beta: a new role for an old AktTOR. Developmental Cell. 17: 6-8. PMID 19619487 DOI: 10.1016/J.Devcel.2009.07.004 |
0.335 |
|
| 2009 |
Rathmell JC, Newgard CB. Biochemistry. A glucose-to-gene link. Science (New York, N.Y.). 324: 1021-2. PMID 19460991 DOI: 10.1126/Science.1174665 |
0.395 |
|
| 2009 |
Altman BJ, Rathmell JC. Autophagy: not good OR bad, but good AND bad. Autophagy. 5: 569-70. PMID 19398886 DOI: 10.4161/Auto.5.4.8254 |
0.786 |
|
| 2009 |
Altman BJ, Wofford JA, Zhao Y, Coloff JL, Ferguson EC, Wieman HL, Day AE, Ilkayeva O, Rathmell JC. Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. Molecular Biology of the Cell. 20: 1180-91. PMID 19109422 DOI: 10.1091/Mbc.E08-08-0829 |
0.787 |
|
| 2009 |
Wardell SE, Ilkayeva OR, Wieman HL, Frigo DE, Rathmell JC, Newgard CB, McDonnell DP. Glucose metabolism as a target of histone deacetylase inhibitors. Molecular Endocrinology (Baltimore, Md.). 23: 388-401. PMID 19106193 DOI: 10.1210/Jcem.94.2.9997 |
0.815 |
|
| 2009 |
Wieman HL, Horn SR, Jacobs SR, Altman BJ, Kornbluth S, Rathmell JC. An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. The Biochemical Journal. 418: 345-67. PMID 19016655 DOI: 10.1042/Bj20081422 |
0.819 |
|
| 2008 |
Zhao Y, Coloff JL, Ferguson EC, Jacobs SR, Cui K, Rathmell JC. Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation Journal of Biological Chemistry. 283: 36344-36353. PMID 18990690 DOI: 10.1074/Jbc.M803580200 |
0.864 |
|
| 2008 |
Michalek RD, Rathmell JC. Methed-up FOXOs can't in-Akt-ivate. Molecular Cell. 32: 160-2. PMID 18951081 DOI: 10.1016/j.molcel.2008.10.006 |
0.399 |
|
| 2008 |
Zhao Y, Wieman HL, Jacobs SR, Rathmell JC. Chapter Twenty-Two Mechanisms and Methods in Glucose Metabolism and Cell Death Methods in Enzymology. 442: 439-457. PMID 18662583 DOI: 10.1016/S0076-6879(08)01422-5 |
0.841 |
|
| 2008 |
Ferguson EC, Rathmell JC. New roles for pyruvate kinase M2: working out the Warburg effect. Trends in Biochemical Sciences. 33: 359-62. PMID 18603432 DOI: 10.1016/j.tibs.2008.05.006 |
0.339 |
|
| 2008 |
MacIver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC. Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival Journal of Leukocyte Biology. 84: 949-957. PMID 18577716 DOI: 10.1189/Jlb.0108024 |
0.83 |
|
| 2008 |
Jacobs SR, Herman CE, MacIver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC. Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways Journal of Immunology. 180: 4476-4486. PMID 18354169 DOI: 10.4049/Jimmunol.180.7.4476 |
0.831 |
|
| 2008 |
Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival Blood. 111: 2101-2111. PMID 18042802 DOI: 10.1182/blood-2007-06-096297 |
0.796 |
|
| 2007 |
Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 104: 12105-10. PMID 17609365 DOI: 10.1073/Pnas.0705285104 |
0.805 |
|
| 2007 |
Rathmell JC, Kornbluth S. Filling a GAP(DH) in caspase-independent cell death. Cell. 129: 861-3. PMID 17540167 DOI: 10.1016/J.Cell.2007.05.030 |
0.358 |
|
| 2007 |
Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Molecular and Cellular Biology. 27: 4328-39. PMID 17371841 DOI: 10.1128/Mcb.00153-07 |
0.803 |
|
| 2007 |
Wieman HL, Wofford JA, Rathmell JC. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Molecular Biology of the Cell. 18: 1437-46. PMID 17301289 DOI: 10.1091/Mbc.E06-07-0593 |
0.839 |
|
| 2006 |
Coloff JL, Rathmell JC. Metabolic regulation of Akt: roles reversed. The Journal of Cell Biology. 175: 845-7. PMID 17158959 DOI: 10.1083/Jcb.200610119 |
0.746 |
|
| 2006 |
Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portocarrero CP, Keister BA, Belka GK, Cho H, Rathmell JC, Thompson CB, Birnbaum MJ, Chodosh LA. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metabolism. 4: 475-90. PMID 17141631 DOI: 10.1016/J.Cmet.2006.10.011 |
0.455 |
|
| 2006 |
Deming PB, Rathmell JC. Mitochondria, cell death, and B cell tolerance. Current Directions in Autoimmunity. 9: 95-119. PMID 16394657 DOI: 10.1159/000090774 |
0.354 |
|
| 2006 |
Jacobs SR, Rathmell JC. Lymphocyte selection by starvation: Glucose metabolism and cell death Trends in Immunology. 27: 4-7. PMID 16300996 DOI: 10.1016/J.It.2005.11.002 |
0.808 |
|
| 2005 |
Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC, Kornbluth S. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell. 123: 89-103. PMID 16213215 DOI: 10.1016/J.Cell.2005.07.032 |
0.399 |
|
| 2005 |
Cinalli RM, Herman CE, Lew BO, Wieman HL, Thompson CB, Rathmell JC. T cell homeostasis requires G protein-coupled receptor-mediated access to trophic signals that promote growth and inhibit chemotaxis. European Journal of Immunology. 35: 786-95. PMID 15719365 DOI: 10.1002/Eji.200425729 |
0.781 |
|
| 2004 |
Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, Rathmell JC, Riley JL, Thompson CB. Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1303-5. PMID 15180958 DOI: 10.1096/Fj.03-1001Fje |
0.511 |
|
| 2004 |
Rathmell JC. B-cell homeostasis: digital survival or analog growth? Immunological Reviews. 197: 116-28. PMID 14962191 |
0.438 |
|
| 2003 |
Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Molecular and Cellular Biology. 23: 7315-28. PMID 14517300 DOI: 10.1128/Mcb.23.20.7315-7328.2003 |
0.613 |
|
| 2003 |
Rathmell JC, Elstrom RL, Cinalli RM, Thompson CB. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. European Journal of Immunology. 33: 2223-32. PMID 12884297 DOI: 10.1002/Eji.200324048 |
0.394 |
|
| 2002 |
Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nature Immunology. 3: 932-9. PMID 12244308 DOI: 10.1038/Ni834 |
0.399 |
|
| 2002 |
Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB. The CD28 signaling pathway regulates glucose metabolism. Immunity. 16: 769-77. PMID 12121659 DOI: 10.1016/S1074-7613(02)00323-0 |
0.481 |
|
| 2002 |
Plas DR, Rathmell JC, Thompson CB. Homeostatic control of lymphocyte survival: potential origins and implications. Nature Immunology. 3: 515-21. PMID 12032565 DOI: 10.1038/Ni0602-515 |
0.314 |
|
| 2002 |
Rathmell JC, Thompson CB. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell. 109: S97-107. PMID 11983156 DOI: 10.1016/S0092-8674(02)00704-3 |
0.35 |
|
| 2001 |
Rathmell JC, Farkash EA, Gao W, Thompson CB. IL-7 enhances the survival and maintains the size of naive T cells. Journal of Immunology (Baltimore, Md. : 1950). 167: 6869-76. PMID 11739504 DOI: 10.4049/Jimmunol.167.12.6869 |
0.345 |
|
| 2001 |
Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB. Growth factors can influence cell growth and survival through effects on glucose metabolism Molecular and Cellular Biology. 21: 5899-5912. PMID 11486029 DOI: 10.1128/Mcb.21.17.5899-5912.2001 |
0.51 |
|
| 2001 |
Plas DR, Talapatra S, Edinger AL, Rathmell JC, Thompson CB. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. The Journal of Biological Chemistry. 276: 12041-8. PMID 11278698 DOI: 10.1074/Jbc.M010551200 |
0.403 |
|
| 2000 |
Rathmell JC, Vander Heiden MG, Harris MH, Frauwirth KA, Thompson CB. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Molecular Cell. 6: 683-92. PMID 11030347 DOI: 10.1016/S1097-2765(00)00066-6 |
0.539 |
|
| 1999 |
Rathmell JC, Thompson CB. The central effectors of cell death in the immune system Annual Review of Immunology. 17: 781-828. PMID 10358774 DOI: 10.1146/Annurev.Immunol.17.1.781 |
0.334 |
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