| Year |
Citation |
Score |
| 2024 |
McGrath MK, Abolhassani A, Guy L, Elshazly AM, Barrett JT, Mivechi NF, Gewirtz DA, Schoenlein PV. Autophagy and senescence facilitate the development of antiestrogen resistance in ER positive breast cancer. Frontiers in Endocrinology. 15: 1298423. PMID 38567308 DOI: 10.3389/fendo.2024.1298423 |
0.339 |
|
| 2024 |
Chen X, Tsvetkov AS, Shen HM, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon HU, Galluzzi L, Luo S, Xu D, Gu W, Peulen O, Cai Q, Rubinsztein DC, ... ... Gewirtz DA, et al. International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy. PMID 38442890 DOI: 10.1080/15548627.2024.2319901 |
0.317 |
|
| 2023 |
Softah A, Alotaibi MR, Alhoshani AR, Saleh T, Alhazzani K, Almutairi MM, AlRowis R, Alshehri S, Albekairy NA, Harada H, Boyd R, Chakraborty E, Gewirtz DA, As Sobeai HM. The Combination of Radiation with PARP Inhibition Enhances Senescence and Sensitivity to the Senolytic, Navitoclax, in Triple Negative Breast Tumor Cells. Biomedicines. 11. PMID 38002066 DOI: 10.3390/biomedicines11113066 |
0.777 |
|
| 2023 |
Elshazly AM, Gewirtz DA. The Cytoprotective Role of Autophagy in Response to BRAF-Targeted Therapies. International Journal of Molecular Sciences. 24. PMID 37834222 DOI: 10.3390/ijms241914774 |
0.302 |
|
| 2023 |
Elshazly AM, Gewirtz DA. Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors. International Journal of Molecular Sciences. 24. PMID 37628849 DOI: 10.3390/ijms241612669 |
0.307 |
|
| 2023 |
Elshazly AM, Sinanian MM, Neely V, Chakraborty E, Alshehri MA, McGrath MK, Harada H, Schoenlein PV, Gewirtz DA. BRD4 Inhibition as a Strategy to Prolong the Response to Standard of Care in Estrogen Receptor-Positive Breast Cancer. Cancers. 15. PMID 37627092 DOI: 10.3390/cancers15164066 |
0.346 |
|
| 2023 |
Elshazly AM, Gewirtz DA. Is Autophagy Inhibition in Combination with Temozolomide a Therapeutically Viable Strategy? Cells. 12. PMID 36831202 DOI: 10.3390/cells12040535 |
0.39 |
|
| 2023 |
Finnegan RM, Elshazly AM, Patel NH, Tyutyunyk-Massey L, Tran TH, Kumarasamy V, Knudsen ES, Gewirtz DA. The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant + Palbociclib and suppresses proliferative recovery in ER-positive breast cancer. Frontiers in Oncology. 12: 966441. PMID 36741704 DOI: 10.3389/fonc.2022.966441 |
0.435 |
|
| 2022 |
Elshazly AM, Wright PA, Xu J, Gewirtz DA. Topoisomerase I poisons-induced autophagy: Cytoprotective, Cytotoxic or Non-protective. Autophagy Reports. 2: 1-16. PMID 36936397 DOI: 10.1080/27694127.2022.2155904 |
0.38 |
|
| 2022 |
Hagan ML, Mander S, Joseph C, McGrath M, Barrett A, Lewis A, Hill WD, Browning D, McGee-Lawrence ME, Cai H, Liu K, Barrett JT, Gewirtz DA, Thangaraju M, Schoenlein PV. Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen‑induced BimEL dependent apoptosis in ER breast cancer cells. International Journal of Oncology. 62. PMID 36524361 DOI: 10.3892/ijo.2022.5468 |
0.368 |
|
| 2022 |
Finnegan RM, Elshazly AM, Schoenlein PV, Gewirtz DA. Therapeutic Potential for Targeting Autophagy in ER+ Breast Cancer. Cancers. 14. PMID 36077830 DOI: 10.3390/cancers14174289 |
0.429 |
|
| 2022 |
Nelczyk AT, Ma L, Gupta AD, Gamage HEV, McHenry MT, Henn MA, Kadiri M, Wang Y, Krawczynska N, Bendre S, He S, Shahoei SH, Madak-Erdogan Z, Hsiao SH, Saleh T, ... ... Gewirtz DA, et al. The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 166515. PMID 35932893 DOI: 10.1016/j.bbadis.2022.166515 |
0.322 |
|
| 2022 |
Xu J, Elshazly AM, Gewirtz DA. The Cytoprotective, Cytotoxic and Nonprotective Functional Forms of Autophagy Induced by Microtubule Poisons in Tumor Cells-Implications for Autophagy Modulation as a Therapeutic Strategy. Biomedicines. 10. PMID 35884937 DOI: 10.3390/biomedicines10071632 |
0.4 |
|
| 2022 |
Xu J, Gewirtz DA. Is Autophagy Always a Barrier to Cisplatin Therapy? Biomolecules. 12. PMID 35327655 DOI: 10.3390/biom12030463 |
0.397 |
|
| 2022 |
Saleh T, Gewirtz DA. Considering therapy-induced senescence as a mechanism of tumour dormancy contributing to disease recurrence. British Journal of Cancer. PMID 35304605 DOI: 10.1038/s41416-022-01787-6 |
0.332 |
|
| 2021 |
As Sobeai HM, Alohaydib M, Alhoshani AR, Alhazzani K, Almutairi MM, Saleh T, Gewirtz DA, Alotiabi MR. Sorafenib, rapamycin, and venetoclax attenuate doxorubicin-induced senescence and promote apoptosis in HCT116 cells. Saudi Pharmaceutical Journal : Spj : the Official Publication of the Saudi Pharmaceutical Society. 30: 91-101. PMID 35145348 DOI: 10.1016/j.jsps.2021.12.004 |
0.46 |
|
| 2021 |
Ahmadinejad F, Bos T, Hu B, Britt E, Koblinski J, Souers AJ, Leverson JD, Faber AC, Gewirtz DA, Harada H. . Molecular Pharmacology. PMID 34907000 DOI: 10.1124/molpharm.121.000354 |
0.38 |
|
| 2021 |
Mahapatra KK, Mishra SR, Behera BP, Patil S, Gewirtz DA, Bhutia SK. The lysosome as an imperative regulator of autophagy and cell death. Cellular and Molecular Life Sciences : Cmls. PMID 34716768 DOI: 10.1007/s00018-021-03988-3 |
0.333 |
|
| 2021 |
Carpenter V, Saleh T, Min Lee S, Murray G, Reed J, Souers A, Faber A, Harada H, Gewirtz DA. Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy. Biochemical Pharmacology. 114765. PMID 34536356 DOI: 10.1016/j.bcp.2021.114765 |
0.373 |
|
| 2021 |
Patel NH, Bloukh S, Alwohosh E, Alhesa A, Saleh T, Gewirtz DA. Autophagy and senescence in cancer therapy. Advances in Cancer Research. 150: 1-74. PMID 33858594 DOI: 10.1016/bs.acr.2021.01.002 |
0.443 |
|
| 2021 |
Tyutyunyk-Massey L, Sun Y, Dao N, Ngo H, Dammalapati M, Vaidyanathan A, Singh M, Haqqani S, Haueis J, Finnegan R, Xiaoyan D, Kirberger S, Bos P, Bandyopadhyay D, Pomerantz W, ... ... Gewirtz D, et al. Autophagy Dependent Sensitization of Triple Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of The Nucleosome Remodeling Factor. Molecular Cancer Research : McR. PMID 33811160 DOI: 10.1158/1541-7786.MCR-20-0743 |
0.421 |
|
| 2021 |
Prasanna PG, Citrin DE, Hildesheim J, Ahmed MM, Venkatachalam S, Riscuta G, Xi D, Zheng G, van Deursen J, Goronzy J, Kron SJ, Anscher MS, Sharpless NE, Campisi J, Brown SL, ... ... Gewirtz DA, et al. Therapy-Induced Senescence: Opportunities to Improve Anti-Cancer Therapy. Journal of the National Cancer Institute. PMID 33792717 DOI: 10.1093/jnci/djab064 |
0.422 |
|
| 2021 |
Carpenter VJ, Saleh T, Gewirtz DA. Senolytics for Cancer Therapy: Is All That Glitters Really Gold? Cancers. 13. PMID 33578753 DOI: 10.3390/cancers13040723 |
0.322 |
|
| 2020 |
Saleh T, Carpenter VJ, Bloukh S, Gewirtz DA. Targeting tumor cell senescence and polyploidy as potential therapeutic strategies. Seminars in Cancer Biology. PMID 33358748 DOI: 10.1016/j.semcancer.2020.12.010 |
0.42 |
|
| 2020 |
Xu J, Patel NH, Gewirtz DA. Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance. International Journal of Molecular Sciences. 21. PMID 33256191 DOI: 10.3390/ijms21238991 |
0.332 |
|
| 2020 |
Carpenter VJ, Patel BB, Autorino R, Smith SC, Gewirtz DA, Saleh T. Senescence and castration resistance in prostate cancer: A review of experimental evidence and clinical implications. Biochimica Et Biophysica Acta. Reviews On Cancer. 188424. PMID 32956765 DOI: 10.1016/J.Bbcan.2020.188424 |
0.426 |
|
| 2020 |
Patel NH, Sohal SS, Manjili MH, Harrell JC, Gewirtz DA. The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation. Radiation Research. 194: 103-115. PMID 32845995 DOI: 10.1667/Rade-20-00009 |
0.616 |
|
| 2020 |
Saleh T, Carpenter VJ, Tyutyunyk-Massey L, Murray G, Leverson JD, Souers AJ, Alotaibi MR, Faber A, Reed J, Harada H, Gewirtz DA. Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX Interaction. Molecular Oncology. PMID 32652830 DOI: 10.1002/1878-0261.12761 |
0.753 |
|
| 2020 |
Paez PA, Kolawole EM, Taruselli MT, Ajith S, Dailey JM, Kee SA, Haque TT, Barnstein BO, McLeod JJA, Caslin HL, Kiwanuka KN, Fukuoka Y, Le QT, Schwartz LB, Straus DB, ... Gewirtz DA, et al. Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells. The Journal of Pharmacology and Experimental Therapeutics. PMID 32434944 DOI: 10.1124/Jpet.119.264234 |
0.5 |
|
| 2020 |
Saleh T, Bloukh S, Carpenter VJ, Alwohoush E, Bakeer J, Darwish S, Azab B, Gewirtz DA. Therapy-Induced Senescence: An "Old" Friend Becomes the Enemy. Cancers. 12. PMID 32235364 DOI: 10.3390/Cancers12040822 |
0.548 |
|
| 2020 |
Patel NH, Xu J, Saleh T, Wu Y, Lima S, Gewirtz DA. Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells. Biochemical Pharmacology. 113896. PMID 32135156 DOI: 10.1016/J.Bcp.2020.113896 |
0.561 |
|
| 2020 |
Gewirtz DA. The Switch between Protective and Nonprotective Autophagy; Implications for Autophagy Inhibition as a Therapeutic Strategy in Cancer. Biology. 9. PMID 31947952 DOI: 10.3390/Biology9010012 |
0.588 |
|
| 2019 |
Tyutyunyk-Massey L, Gewirtz DA. Roles of autophagy in breast cancer treatment: target, bystander or benefactor. Seminars in Cancer Biology. PMID 31887364 DOI: 10.1016/J.Semcancer.2019.11.008 |
0.462 |
|
| 2019 |
Toma W, Kyte SL, Bagdas D, Jackson A, Meade JA, Rahman F, Chen ZJ, Del Fabbro E, Cantwell L, Kulkarni A, Thakur GA, Papke RL, Bigbee JW, Gewirtz DA, Damaj MI. The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal. Experimental Neurology. 113010. PMID 31299179 DOI: 10.1016/J.Expneurol.2019.113010 |
0.35 |
|
| 2019 |
Saleh T, Tyutyunyk-Massey L, Gewirtz DA. Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after Dormancy. Cancer Research. PMID 30803994 DOI: 10.1158/0008-5472.Can-18-3437 |
0.484 |
|
| 2019 |
Carpenter VJ, Saleh T, Gewirtz DA. Abstract 902: The antiandrogen bicalutamide induces senescence in LNCaP cells and quiescence in Myc CaP cells Cancer Research. 79: 902-902. DOI: 10.1158/1538-7445.Am2019-902 |
0.5 |
|
| 2019 |
Saleh T, Tyutyunyk-Massey L, Murray GF, Alotaibi MR, Kawale AS, Elsayed Z, Henderson SC, Yakovlev V, Elmore LW, Toor A, Harada H, Reed J, Landry JW, Gewirtz DA. Abstract 901: Elimination of senescent tumor cells by ABT263 interferes with proliferative recovery and provides a two-hit therapeutic approach Cancer Research. 79: 901-901. DOI: 10.1158/1538-7445.Am2019-901 |
0.768 |
|
| 2019 |
Tyutyunyk L, Saleh T, Gewirtz DA. Abstract 899: Selective clearance of cells undergoing therapy-induced senescence in a model of triple negative breast cancer Cancer Research. 79: 899-899. DOI: 10.1158/1538-7445.Am2019-899 |
0.614 |
|
| 2019 |
Xu J, Patel N, Saleh T, Wu Y, Lima S, Gewirtz DA. Abstract 4278: A comparison of drug sensitivity in isogenic tumor cell lines confirms that cytoprotective autophagy confers intrinsic resistance to cisplatin Cancer Research. 79: 4278-4278. DOI: 10.1158/1538-7445.Am2019-4278 |
0.595 |
|
| 2019 |
Tyutyunyk L, Gewirtz DA, Landry J, Dao N. Abstract 4272: Suppression of epigenetic regulator NURF leads to autophagy mediated chemo-and immune sensitization of triple negative breast cancer Cancer Research. 79: 4272-4272. DOI: 10.1158/1538-7445.Am2019-4272 |
0.594 |
|
| 2018 |
Saleh T, Tyutyunyk-Massey L, Murray GF, Alotaibi MR, Kawale AS, Elsayed Z, Henderson SC, Yakovlev V, Elmore LW, Toor A, Harada H, Reed J, Landry JW, Gewirtz DA. Tumor cell escape from therapy-induced senescence. Biochemical Pharmacology. PMID 30576620 DOI: 10.1016/J.Bcp.2018.12.013 |
0.764 |
|
| 2018 |
Xu J, Patel NH, Saleh T, Cudjoe EK, Alotaibi M, Wu Y, Lima S, Hawkridge AM, Gewirtz DA. Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy. Radiation Research. PMID 30132722 DOI: 10.1667/Rr15099.1 |
0.812 |
|
| 2018 |
Saleh T, Tyutynuk-Massey L, Cudjoe EK, Idowu MO, Landry JW, Gewirtz DA. Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy. Frontiers in Oncology. 8: 164. PMID 29868482 DOI: 10.3389/Fonc.2018.00164 |
0.481 |
|
| 2018 |
Kyte SL, Gewirtz DA. The Influence of Nicotine on Lung Tumor Growth, Cancer Chemotherapy, and Chemotherapy-Induced Peripheral Neuropathy. The Journal of Pharmacology and Experimental Therapeutics. PMID 29866790 DOI: 10.1124/Jpet.118.249359 |
0.385 |
|
| 2018 |
Aqbi HF, Tyutyunyk-Massey L, Keim RC, Butler SE, Thekkudan T, Joshi S, Smith TM, Bandyopadhyay D, Idowu MO, Bear HD, Payne KK, Gewirtz DA, Manjili MH. Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy. Oncotarget. 9: 22113-22122. PMID 29774126 DOI: 10.18632/Oncotarget.25197 |
0.535 |
|
| 2018 |
Tyutyunyk-Massey L, Haqqani SU, Mandava R, Kentiba K, Dammalapati M, Dao N, Haueis J, Gewirtz D, Landry JW. Leveraging Epigenetics to Enhance the Cellular Response to Chemotherapies and Improve Tumor Immunogenicity. Advances in Cancer Research. 138: 1-39. PMID 29551125 DOI: 10.1016/Bs.Acr.2018.02.001 |
0.501 |
|
| 2018 |
Gewirtz DA, Tyutyunyk-Massey L, Landry JW. The Potentially Conflicting Cell Autonomous and Cell Non-Autonomous Functions of Autophagy in Mediating Tumor Response to Cancer Therapy. Biochemical Pharmacology. PMID 29408462 DOI: 10.1016/J.Bcp.2018.01.048 |
0.543 |
|
| 2018 |
Saleh T, Alotaibi MR, Kyte SL, Cudjoe EK, Kawale A, Xu J, Elsayed Z, Landry JW, Henderson SC, Yakovlev V, Elmore LW, Gewirtz DA. Abstract 459: Therapy-induced senescence is reversible in vitro and in vivo Cancer Research. 78: 459-459. DOI: 10.1158/1538-7445.Am2018-459 |
0.768 |
|
| 2018 |
Xu J, Cudjoe EK, Saleh T, Patel N, Alotaibi M, Wu Y, Lima S, Gewirtz D. Abstract 1326: Nonprotective autophagy fails to confer resistance to radiation Cancer Research. 78: 1326-1326. DOI: 10.1158/1538-7445.Am2018-1326 |
0.788 |
|
| 2018 |
Xu J, Saleh T, Patel N, Wu Y, Lima S, Gewirtz D. Abstract 1323: A p53-dependent switch between cytoprotective and nonprotective autophagy influences tumor cell sensitivity to cisplatin Cancer Research. 78: 1323-1323. DOI: 10.1158/1538-7445.Am2018-1323 |
0.545 |
|
| 2017 |
Kyte SL, Toma W, Bagdas D, Meade JA, Schurman LD, Lichtman AH, Chen ZJ, Del Fabbro E, Fang X, Bigbee JW, Damaj MI, Gewirtz DA. Nicotine prevents and reverses paclitaxel-induced mechanical allodynia in a mouse model of CIPN. The Journal of Pharmacology and Experimental Therapeutics. PMID 29042416 DOI: 10.1124/Jpet.117.243972 |
0.398 |
|
| 2017 |
Cudjoe EK, Saleh T, Hawkridge A, Gewirtz DA. Proteomics Insights into Autophagy. Proteomics. PMID 28902446 DOI: 10.1002/Pmic.201700022 |
0.38 |
|
| 2017 |
Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, ... ... Gewirtz DA, et al. Molecular definitions of autophagy and related processes. The Embo Journal. PMID 28596378 DOI: 10.15252/Embj.201796697 |
0.32 |
|
| 2017 |
Toma W, Kyte SL, Bagdas D, Alkhlaif Y, Alsharari SD, Lichtman AH, Chen ZJ, Del Fabbro E, Bigbee JW, Gewirtz DA, Damaj MI. Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse. Neuropharmacology. PMID 28237807 DOI: 10.1016/J.Neuropharm.2017.02.020 |
0.345 |
|
| 2017 |
Kyte SL, Toma W, Thakur G, Damaj MI, Gewirtz DA. Abstract 986: Targeting nicotinic acetylcholine receptors for the prevention and reversal of chemotherapy-induced peripheral neuropathy Cancer Research. 77: 986-986. DOI: 10.1158/1538-7445.Am2017-986 |
0.429 |
|
| 2017 |
Saleh T, Cudjoe EK, Kyte SL, Henderson SC, Elmore LW, Gewirtz DA. Abstract 5470: Reversibility of therapy-induced senescence in non-small cell lung cancer as a model of cancer recurrence Cancer Research. 77: 5470-5470. DOI: 10.1158/1538-7445.Am2017-5470 |
0.553 |
|
| 2017 |
Tyutyunyk L, Thekkudan T, Saleh T, Gewirtz DA. Abstract 5459: Autophagy and senescence as possible mechanisms leading to proliferative recovery and escape from treatment-induced tumor dormancy Cancer Research. 77: 5459-5459. DOI: 10.1158/1538-7445.Am2017-5459 |
0.418 |
|
| 2017 |
Tyutyunyk L, Landry J, Saleh T, Gewirtz D. Abstract 3314: Synergistic effects of chemotherapy-induced autophagy and epigenetic remodeling Cancer Research. 77: 3314-3314. DOI: 10.1158/1538-7445.Am2017-3314 |
0.376 |
|
| 2017 |
Xu J, Saleh T, Tyutynuk-Massey L, Wu Y, Gewirtz DA. Abstract 3299: Radiation induced p53-dependent cytoprotective autophagy fails to reduce radiation sensitivity in H460 non-small cell lung cancer cells Cancer Research. 77: 3299-3299. DOI: 10.1158/1538-7445.Am2017-3299 |
0.546 |
|
| 2017 |
Cudjoe EK, Saleh T, Gewirtz DA, Hawkridge AM. Abstract 227: Mass spectrometry-based proteomics analysis of the non-small cell lung cancer secretome Cancer Research. 77: 227-227. DOI: 10.1158/1538-7445.Am2017-227 |
0.449 |
|
| 2016 |
Gewirtz DA. The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy. Cancer Research. PMID 27634767 DOI: 10.1158/0008-5472.Can-16-0722 |
0.488 |
|
| 2016 |
Gewirtz DA, Alotaibi M, Yakovlev VA, Povirk LF. Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition. Radiation Research. PMID 27588595 DOI: 10.1667/Rr14437.1 |
0.767 |
|
| 2016 |
Saleh T, Cuttino L, Gewirtz DA. Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer. Biochimica Et Biophysica Acta. PMID 27316314 DOI: 10.1016/J.Bbagen.2016.06.012 |
0.5 |
|
| 2016 |
Alotaibi M, Sharma K, Saleh T, Povirk LF, Hendrickson EA, Gewirtz DA. Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Radiation Research. PMID 26934368 DOI: 10.1667/Rr14202.1 |
0.863 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Gewirtz DA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.35 |
|
| 2016 |
Chakradeo S, Elmore LW, Gewirtz DA. Is Senescence Reversible? Current Drug Targets. 17: 460-6. PMID 26302802 DOI: 10.2174/1389450116666150825113500 |
0.592 |
|
| 2016 |
Kyte SL, Toma W, Damaj MI, Fang X, Gewirtz DA. Abstract 3574: Nicotine prevents chemotherapy-induced peripheral neuropathy in vivo, and fails to stimulate the growth of lung cancer cells or interfere with the effectiveness of chemotherapy in vitro Cancer Research. 76: 3574-3574. DOI: 10.1158/1538-7445.Am2016-3574 |
0.431 |
|
| 2016 |
Thekkudan T, Sharma K, Saleh T, Gewirtz D. Abstract 3539: Vitamin D/EB 1089 mediated radio-sensitization of lung cancer cells and head and neck cancer cells Cancer Research. 76: 3539-3539. DOI: 10.1158/1538-7445.Am2016-3539 |
0.796 |
|
| 2016 |
Thekkudan T, Joshi S, Gewirtz D. Abstract 3528: Induction of cytoprotective autophagy and senescence in response to chemotherapy and ionizing-radiation as possible mechanisms of tumor dormancy Cancer Research. 76: 3528-3528. DOI: 10.1158/1538-7445.Am2016-3528 |
0.632 |
|
| 2016 |
Alotaibi MR, Sharma K, Saleh T, Povirk L, Hendrickson E, Gewirtz D. Abstract 2848: Autophagy, senescence and proliferative recovery subsequent to DNA damage in radiation sensitization by PARP inhibition Cancer Research. 76: 2848-2848. DOI: 10.1158/1538-7445.Am2016-2848 |
0.863 |
|
| 2016 |
Saleh T, Thekkudan T, Alotaibi MR, Gewirtz DA. Abstract 2846: Proliferative recovery after chemotherapy-induced senescence in non-small cell lung cancer (NSCLC) cells as a model of tumor dormancy and disease recurrence Cancer Research. 76: 2846-2846. DOI: 10.1158/1538-7445.Am2016-2846 |
0.766 |
|
| 2015 |
Mezzaroma E, Mikkelsen RB, Toldo S, Mauro AG, Sharma K, Marchetti C, Alam A, Van Tassell BW, Gewirtz DA, Abbate A. Role of Interleukin-1 in Radiation-Induced Cardiomyopathy. Molecular Medicine (Cambridge, Mass.). 21: 210-8. PMID 25822795 DOI: 10.2119/Molmed.2014.00243 |
0.669 |
|
| 2015 |
Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, et al. Autophagy in malignant transformation and cancer progression. The Embo Journal. 34: 856-80. PMID 25712477 DOI: 10.15252/Embj.201490784 |
0.477 |
|
| 2015 |
Chakradeo S, Sharma K, Alhaddad A, Bakhshwin D, Le N, Harada H, Nakajima W, Yeudall WA, Torti SV, Torti FM, Gewirtz DA. Yet another function of p53--the switch that determines whether radiation-induced autophagy will be cytoprotective or nonprotective: implications for autophagy inhibition as a therapeutic strategy. Molecular Pharmacology. 87: 803-14. PMID 25667224 DOI: 10.1124/Mol.114.095273 |
0.82 |
|
| 2015 |
Chakradeo S, Sharma K, Alhaddad A, Bakhshwin D, Le N, Harada H, Yeudall WA, Torti S, Torti F, Gewirtz D. Abstract 998: Induction of non-protective autophagy by radiation in tumor cells: Implications for autophagy inhibition as a therapeutic strategy Cancer Research. 75: 998-998. DOI: 10.1158/1538-7445.Am2015-998 |
0.835 |
|
| 2015 |
Sharma K, Thekkudan T, Gewirtz D, Harada H, Torti F, Torti S. Abstract 1013: Understanding the molecular pathways underlying radio-sensitization of non-small cell lung cancer (NSCLC) by vitamin D (EB1089) Cancer Research. 75: 1013-1013. DOI: 10.1158/1538-7445.Am2015-1013 |
0.793 |
|
| 2014 |
Sharma K, Goehe R, Beckta JM, Valerie K, Gewirtz DA. Autophagy and radiosensitization in cancer. Excli Journal. 13: 178-91. PMID 26417252 DOI: 10.17877/De290R-197 |
0.812 |
|
| 2014 |
Sharma K, Goehe RW, Di X, Hicks MA, Torti SV, Torti FM, Harada H, Gewirtz DA. A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Autophagy. 10: 2346-61. PMID 25629933 DOI: 10.4161/15548627.2014.993283 |
0.854 |
|
| 2014 |
Gewirtz DA. The autophagic response to radiation: relevance for radiation sensitization in cancer therapy. Radiation Research. 182: 363-7. PMID 25184372 DOI: 10.1667/Rr13774.1 |
0.553 |
|
| 2014 |
Poklepovic A, Gewirtz DA. Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer. Autophagy. 10: 1478-80. PMID 24991829 DOI: 10.4161/Auto.29428 |
0.318 |
|
| 2014 |
Sharma K, Le N, Alotaibi M, Gewirtz DA. Cytotoxic autophagy in cancer therapy. International Journal of Molecular Sciences. 15: 10034-51. PMID 24905404 DOI: 10.3390/Ijms150610034 |
0.858 |
|
| 2014 |
Gewirtz DA. An autophagic switch in the response of tumor cells to radiation and chemotherapy. Biochemical Pharmacology. 90: 208-11. PMID 24875447 DOI: 10.1016/J.Bcp.2014.05.016 |
0.566 |
|
| 2014 |
Gewirtz DA. The four faces of autophagy: implications for cancer therapy. Cancer Research. 74: 647-51. PMID 24459182 DOI: 10.1158/0008-5472.Can-13-2966 |
0.605 |
|
| 2014 |
Gewirtz DA. When cytoprotective autophagy isn't… and even when it is. Autophagy. 10: 391-2. PMID 24419177 DOI: 10.4161/Auto.27719 |
0.598 |
|
| 2014 |
Emery SM, Alotaibi MR, Tao Q, Selley DE, Lichtman AH, Gewirtz DA. Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. The Journal of Pharmacology and Experimental Therapeutics. 348: 293-302. PMID 24259678 DOI: 10.1124/Jpet.113.205120 |
0.763 |
|
| 2014 |
Gewirtz DA. Autophagy and senescence in cancer therapy. Journal of Cellular Physiology. 229: 6-9. PMID 23794221 DOI: 10.1002/Jcp.24420 |
0.557 |
|
| 2013 |
Alotaibi MR, Asnake B, Di X, Beckman MJ, Durrant D, Simoni D, Baruchello R, Lee RM, Schwartz EL, Gewirtz DA. Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death. Biochemical Pharmacology. 86: 1688-98. PMID 24144631 DOI: 10.1016/J.Bcp.2013.10.007 |
0.83 |
|
| 2013 |
Gewirtz DA. Cytoprotective and nonprotective autophagy in cancer therapy. Autophagy. 9: 1263-5. PMID 23800720 DOI: 10.4161/Auto.25233 |
0.568 |
|
| 2013 |
Gewirtz DA. Autophagy and senescence: a partnership in search of definition. Autophagy. 9: 808-12. PMID 23422284 DOI: 10.4161/Auto.23922 |
0.526 |
|
| 2013 |
Bristol ML, Emery SM, Maycotte P, Thorburn A, Chakradeo S, Gewirtz DA. Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? The Journal of Pharmacology and Experimental Therapeutics. 344: 544-52. PMID 23291713 DOI: 10.1124/Jpet.112.199802 |
0.525 |
|
| 2013 |
Biggers JW, Nguyen T, Di X, Gupton JT, Henderson SC, Emery SM, Alotaibi M, White KL, Brown R, Almenara J, Gewirtz DA. Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14. Cancer Chemotherapy and Pharmacology. 71: 441-55. PMID 23178952 DOI: 10.1007/S00280-012-2024-6 |
0.837 |
|
| 2013 |
Goehe RW, Bristol ML, Wilson EN, Gewirtz DA. Autophagy, senescence, and apoptosis. Methods in Molecular Biology (Clifton, N.J.). 962: 31-48. PMID 23150435 DOI: 10.1007/978-1-62703-236-0_3 |
0.827 |
|
| 2013 |
Sharma K, Gewirtz D. Abstract 1329: Sensitization of non-small cell lung cancer cells (NSCLC) to radiation by Vitamin D (EB 1089) Cancer Research. 74: 1329-1329. DOI: 10.1158/1538-7445.Am2014-1329 |
0.797 |
|
| 2013 |
Dcona MM, Mitra D, Goehe RW, Gewirtz DA, Lebman DA, Hartman MCT. Abstract 5665: New alternatives to photodynamic therapy based on light-enabled drug delivery. Cancer Research. 73: 5665-5665. DOI: 10.1158/1538-7445.Am2013-5665 |
0.413 |
|
| 2013 |
Sharma K, Gewirtz D. Abstract 1329: Sensitization of non-small cell lung cancer cells (NSCLC) to radiation by Vitamin D (EB 1089) Molecular and Cellular Biology. DOI: 10.1158/1538-7445.Am2013-1670 |
0.757 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Gewirtz DA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.329 |
|
| 2012 |
Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, Rodier F, Davalos AR, Gewirtz DA. The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? The Journal of Pharmacology and Experimental Therapeutics. 343: 763-78. PMID 22927544 DOI: 10.1124/Jpet.112.197590 |
0.835 |
|
| 2012 |
Bristol ML, Di X, Beckman MJ, Wilson EN, Henderson SC, Maiti A, Fan Z, Gewirtz DA. Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3. Autophagy. 8: 739-53. PMID 22498493 DOI: 10.4161/Auto.19313 |
0.86 |
|
| 2012 |
Dcona MM, Mitra D, Goehe RW, Gewirtz DA, Lebman DA, Hartman MC. Photocaged permeability: a new strategy for controlled drug release. Chemical Communications (Cambridge, England). 48: 4755-7. PMID 22473358 DOI: 10.1039/C2Cc30819C |
0.333 |
|
| 2012 |
Mezzaroma E, Di X, Graves P, Toldo S, Van Tassell BW, Kannan H, Baumgarten C, Voelkel N, Gewirtz DA, Abbate A. A mouse model of radiation-induced cardiomyopathy. International Journal of Cardiology. 156: 231-3. PMID 22340985 DOI: 10.1016/J.Ijcard.2012.01.038 |
0.726 |
|
| 2012 |
Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Rodier F, Davalos AR, Gewirtz DA. Abstract 4652: The autophagy-senescence connection in chemotherapy of breast tumor cells; senescence accelerated by autophagy but not dependent on autophagy Cancer Research. 72: 4652-4652. DOI: 10.1158/1538-7445.Am2012-4652 |
0.84 |
|
| 2012 |
Bristol ML, Gewirtz DA. Abstract 4114: Dual cytoprotective and cytotoxic functions of autophagy in the response of breast tumor cells to radiation and in radiosensitization by vitamin D3 Molecular and Cellular Biology. DOI: 10.1158/1538-7445.Am2012-4114 |
0.56 |
|
| 2012 |
Alotaibi MR, Beckman MJ, Di X, Lee R, Gewirtz DA. Abstract 3957: Cell death and growth arrest pathways mediating the actions of stilbene 5C in HCT-116 colon cancer cells Cancer Research. 72: 3957-3957. DOI: 10.1158/1538-7445.Am2012-3957 |
0.832 |
|
| 2012 |
Goehe RW, Sharma K, Maiti A, Gewirtz DA. Abstract 1465: Radiosensitization of NSCLC through modulation of autophagy and senescence Cancer Research. 72: 1465-1465. DOI: 10.1158/1538-7445.Am2012-1465 |
0.795 |
|
| 2012 |
Wilson EN, Goehe RW, Maltese WA, Gewirtz DA. Abstract 1454: The role of AMPK in the radiosensitization of breast tumor cells by Vitamin D Cancer Research. 72: 1454-1454. DOI: 10.1158/1538-7445.Am2012-1454 |
0.858 |
|
| 2012 |
Emery SM, Sumner ET, Lichtman AH, Gewirtz DA. Abstract 1453: The cannabinoid Win55, 212-2 enhances the response of breast cancer cells to radiation Cancer Research. 72: 1453-1453. DOI: 10.1158/1538-7445.Am2012-1453 |
0.517 |
|
| 2011 |
Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, et al. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 7: 1273-94. PMID 21997368 DOI: 10.4161/Auto.7.11.17661 |
0.343 |
|
| 2011 |
Wilson EN, Bristol ML, Di X, Maltese WA, Koterba K, Beckman MJ, Gewirtz DA. A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Hormones & Cancer. 2: 272-85. PMID 21887591 DOI: 10.1007/S12672-011-0081-7 |
0.853 |
|
| 2011 |
Wilson EN, Bristol ML, Di X, Beckman MJ, Koterba K, Gewirtz DA. Abstract 2675: Radiosensitization of breast cancer cells by Vitamin D or chloroquine through modulation of the dual cytoprotective and cytotoxic functions of autophagy Cancer Research. 71: 2675-2675. DOI: 10.1158/1538-7445.Am2011-2675 |
0.871 |
|
| 2011 |
Bristol ML, Di X, Gewirtz DA. Abstract 2663: Dual cytoprotective and cytotoxic functions of autophagy in the response ofbreast tumor cells to radiation and in radiosensitization by vitamin D3 Cancer Research. 71: 2663-2663. DOI: 10.1158/1538-7445.Am2011-2663 |
0.657 |
|
| 2011 |
Di X, Bristol ML, Valerie K, Hawkins AJ, Gewirtz DA. Abstract 2638: Association between Adriamycin-induced autophagy and senescence in breast cancer cells Cancer Research. 71: 2638-2638. DOI: 10.1158/1538-7445.Am2011-2638 |
0.539 |
|
| 2011 |
Mezzaroma E, Di X, Graves P, Toldo S, Van Tassell BW, Gewirtz DA, Abbate A. SILDENAFIL PREVENTS RADIATION-INDUCED CARDIOMYOPATHY IN THE MOUSE Journal of the American College of Cardiology. 57: E190. DOI: 10.1016/S0735-1097(11)60190-3 |
0.749 |
|
| 2010 |
Zhang X, Haney KM, Richardson AC, Wilson E, Gewirtz DA, Ware JL, Zehner ZE, Zhang Y. Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents. Bioorganic & Medicinal Chemistry Letters. 20: 4627-30. PMID 20579875 DOI: 10.1016/J.Bmcl.2010.06.003 |
0.774 |
|
| 2010 |
Klionsky DJ, Codogno P, Cuervo AM, Deretic V, Elazar Z, Fueyo-Margareto J, Gewirtz DA, Kroemer G, Levine B, Mizushima N, Rubinsztein DC, Thumm M, Tooze SA. A comprehensive glossary of autophagy-related molecules and processes. Autophagy. 6: 438-48. PMID 20484971 DOI: 10.4161/Auto.6.4.12244 |
0.339 |
|
| 2010 |
Di X, Gennings C, Bear HD, Graham LJ, Sheth CM, White KL, Gewirtz DA. Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells. Breast Cancer Research and Treatment. 124: 349-60. PMID 20155316 DOI: 10.1007/S10549-010-0765-7 |
0.807 |
|
| 2010 |
Hilliker ML, Di X, Henderson S, Gewirtz DA. Abstract 5550: Autophagic potentiation of radiosensitization by vitamin D3 and the analog, EB1089 Cancer Research. 70: 5550-5550. DOI: 10.1158/1538-7445.Am10-5550 |
0.849 |
|
| 2010 |
Di X, Henderson SC, Gewirtz DA. Abstract 3221: Analysis of the relationship between autophagy and senescence in response to Adriamycin in breast tumor cells Cancer Research. 70: 3221-3221. DOI: 10.1158/1538-7445.Am10-3221 |
0.595 |
|
| 2010 |
Wang J, Lin P, Mikkelsen RB, Gewirtz D, Anscher MS, Graves PR. Abstract 1400: Mitigation of radiation-induced injury with the nitric oxide synthase co-factor, tetrahydrobiopterin Cancer Research. 70: 1400-1400. DOI: 10.1158/1538-7445.Am10-1400 |
0.42 |
|
| 2009 |
Gewirtz DA. Autophagy, senescence and tumor dormancy in cancer therapy. Autophagy. 5: 1232-4. PMID 19770583 DOI: 10.4161/Auto.5.8.9896 |
0.492 |
|
| 2009 |
Dalyot-Herman N, Delgado-Lopez F, Gewirtz DA, Gupton JT, Schwartz EL. Interference with endothelial cell function by JG-03-14, an agent that binds to the colchicine site on microtubules. Biochemical Pharmacology. 78: 1167-77. PMID 19576183 DOI: 10.1016/J.Bcp.2009.06.093 |
0.319 |
|
| 2009 |
Gewirtz DA, Hilliker ML, Wilson EN. Promotion of autophagy as a mechanism for radiation sensitization of breast tumor cells. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 92: 323-8. PMID 19541381 DOI: 10.1016/J.Radonc.2009.05.022 |
0.864 |
|
| 2009 |
Di X, Shiu RP, Newsham IF, Gewirtz DA. Apoptosis, autophagy, accelerated senescence and reactive oxygen in the response of human breast tumor cells to adriamycin. Biochemical Pharmacology. 77: 1139-50. PMID 19185564 DOI: 10.1016/J.Bcp.2008.12.016 |
0.819 |
|
| 2008 |
Gewirtz DA, Holt SE, Elmore LW. Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochemical Pharmacology. 76: 947-57. PMID 18657518 DOI: 10.1016/J.Bcp.2008.06.024 |
0.588 |
|
| 2008 |
Di X, Bright AT, Bellott R, Gaskins E, Robert J, Holt S, Gewirtz D, Elmore L. A chemotherapy-associated senescence bystander effect in breast cancer cells. Cancer Biology & Therapy. 7: 864-72. PMID 18340112 DOI: 10.4161/Cbt.7.6.5861 |
0.793 |
|
| 2008 |
Lee RM, Gewirtz DA. Colchicine site inhibitors of microtubule integrity as vascular disrupting agents Drug Development Research. 69: 352-358. DOI: 10.1002/Ddr.20267 |
0.37 |
|
| 2007 |
Arthur CR, Gupton JT, Kellogg GE, Yeudall WA, Cabot MC, Newsham IF, Gewirtz DA. Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison Biochemical Pharmacology. 74: 981-991. PMID 17692290 DOI: 10.1016/J.Bcp.2007.07.003 |
0.591 |
|
| 2007 |
Aris SM, Gewirtz DA, Ryan JJ, Knott KM, Farrell NP. Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes. Biochemical Pharmacology. 73: 1749-57. PMID 17418817 DOI: 10.1016/J.Bcp.2007.02.013 |
0.385 |
|
| 2007 |
Gewirtz DA. Autophagy as a mechanism of radiation sensitization in breast tumor cells. Autophagy. 3: 249-50. PMID 17204856 DOI: 10.4161/Auto.3723 |
0.646 |
|
| 2006 |
Sundaram S, Beckman MJ, Bajwa A, Wei J, Smith KM, Posner GH, Gewirtz DA. QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells Molecular Cancer Therapeutics. 5: 2806-2814. PMID 17121927 DOI: 10.1158/1535-7163.Mct-06-0092 |
0.447 |
|
| 2006 |
Demasters G, Di X, Newsham I, Shiu R, Gewirtz DA. Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery. Molecular Cancer Therapeutics. 5: 2786-97. PMID 17121925 DOI: 10.1158/1535-7163.Mct-06-0316 |
0.852 |
|
| 2006 |
Quick QA, Gewirtz DA. An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells. Journal of Neurosurgery. 105: 111-8. PMID 16871885 DOI: 10.3171/Jns.2006.105.1.111 |
0.485 |
|
| 2006 |
Quick QA, Gewirtz DA. Enhancement of radiation sensitivity, delay of proliferative recovery after radiation and abrogation of MAPK (p44/42) signaling by imatinib in glioblastoma cells. International Journal of Oncology. 29: 407-12. PMID 16820883 DOI: 10.3892/Ijo.29.2.407 |
0.526 |
|
| 2006 |
Gewirtz DA. Caveolin and STAT-5 signaling: potential overlap in lactation and breast tumor promotion. Cancer Biology & Therapy. 5: 298-9. PMID 16627971 DOI: 10.4161/Cbt.5.3.2704 |
0.372 |
|
| 2006 |
Gewirtz DA, Di X, Walker TD, Sawyer ST. Erythropoietin fails to interfere with the antiproliferative and cytotoxic effects of antitumor drugs. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 2232-8. PMID 16609039 DOI: 10.1158/1078-0432.Ccr-05-2287 |
0.808 |
|
| 2005 |
Gewirtz DA, Elmore LW. Apoptosis as the predominant tumor cell response to chemotherapy and irradiation: a case of TUNEL vision? Current Opinion in Investigational Drugs (London, England : 2000). 6: 1199. PMID 16370385 |
0.411 |
|
| 2005 |
Jones KR, Elmore LW, Jackson-Cook C, Demasters G, Povirk LF, Holt SE, Gewirtz DA. p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells. International Journal of Radiation Biology. 81: 445-58. PMID 16308915 DOI: 10.1080/09553000500168549 |
0.841 |
|
| 2005 |
Jones KR, Gewirtz DA, Yannone SM, Zhou S, Schatz DG, Valerie K, Povirk LF. Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein. Molecular Cancer Therapeutics. 4: 1541-7. PMID 16227403 DOI: 10.1158/1535-7163.Mct-05-0193 |
0.713 |
|
| 2005 |
Elmore LW, Di X, Dumur C, Holt SE, Gewirtz DA. Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 2637-43. PMID 15814644 DOI: 10.1158/1078-0432.Ccr-04-1462 |
0.772 |
|
| 2004 |
DeMasters GA, Gupta MS, Jones KR, Cabot M, Wang H, Gennings C, Park M, Bratland A, Ree AH, Gewirtz DA. Potentiation of cell killing by fractionated radiation and suppression of proliferative recovery in MCF-7 breast tumor cells by the Vitamin D3 analog EB 1089. The Journal of Steroid Biochemistry and Molecular Biology. 92: 365-74. PMID 15698541 DOI: 10.1016/J.Jsbmb.2004.07.011 |
0.85 |
|
| 2004 |
Hattangadi DK, DeMasters GA, Walker TD, Jones KR, Di X, Newsham IF, Gewirtz DA. Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell. Biochemical Pharmacology. 68: 1699-708. PMID 15450935 DOI: 10.1016/J.Bcp.2004.06.033 |
0.824 |
|
| 2004 |
Farrell N, Povirk LF, Dange Y, DeMasters G, Gupta MS, Kohlhagen G, Khan QA, Pommier Y, Gewirtz DA. Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells. Biochemical Pharmacology. 68: 857-66. PMID 15294448 DOI: 10.1016/J.Bcp.2004.05.023 |
0.823 |
|
| 2003 |
Sundaram S, Sea A, Feldman S, Strawbridge R, Hoopes PJ, Demidenko E, Binderup L, Gewirtz DA. The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 2350-6. PMID 12796405 |
0.41 |
|
| 2003 |
Polar MK, Gennings C, Park M, Gupta MS, Gewirtz DA. Effect of the vitamin D3 analog ILX 23-7553 on apoptosis and sensitivity to fractionated radiation in breast tumor cells and normal human fibroblasts. Cancer Chemotherapy and Pharmacology. 51: 415-21. PMID 12690516 DOI: 10.1007/S00280-003-0606-Z |
0.597 |
|
| 2002 |
Gewirtz DA, Gupta MS, Sundaram S. Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemo-therapy and radiotherapy. Current Medicinal Chemistry. Anti-Cancer Agents. 2: 683-90. PMID 12678720 DOI: 10.2174/1568011023353697 |
0.391 |
|
| 2002 |
Elmore LW, Rehder CW, Di X, McChesney PA, Jackson-Cook CK, Gewirtz DA, Holt SE. Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. The Journal of Biological Chemistry. 277: 35509-15. PMID 12101184 DOI: 10.1074/Jbc.M205477200 |
0.796 |
|
| 2001 |
Magnet KJ, Orr MS, Cleveland JL, Rodriguez-Galindo C, Yang H, Yang C, Di YM, Jain PT, Gewirtz DA. Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells. Biochemical Pharmacology. 62: 593-602. PMID 11585056 DOI: 10.1016/S0006-2952(01)00699-2 |
0.516 |
|
| 2001 |
Posner GH, Crawford KR, Peleg S, Welsh JE, Romu S, Gewirtz DA, Gupta MS, Dolan P, Kensler TW. A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin. Bioorganic & Medicinal Chemistry. 9: 2365-71. PMID 11553477 DOI: 10.1016/S0968-0896(01)00159-6 |
0.397 |
|
| 2001 |
Chaudhary M, Sundaram S, Gennings C, Carter H, Gewirtz DA. The vitamin D3 analog, ILX-23-7553, enhances the response to Adriamycin and irradiation in MCF-7 breast tumor cells Cancer Chemotherapy and Pharmacology. 47: 429-436. PMID 11391859 DOI: 10.1007/S002800000251 |
0.621 |
|
| 2001 |
Gewirtz DA, Di YM, Randolph JK, Jain PT, Valerie K, Bullock S, Nath N, Chellappan SP. Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol. Archives of Biochemistry and Biophysics. 388: 243-52. PMID 11368161 DOI: 10.1006/Abbi.2000.2278 |
0.529 |
|
| 2001 |
Gewirtz DA, Sundaram S, Magnet KJ. Influence of topoisomerase II inhibitors and ionizing radiation on growth arrest and cell death pathways in the breast tumor cell. Cell Biochemistry and Biophysics. 33: 19-31. PMID 11322510 DOI: 10.1385/Cbb:33:1:19 |
0.643 |
|
| 2001 |
Sundaram S, Chaudhry M, Reardon D, Gupta M, Gewirtz DA. The vitamin D3 analog EB 1089 enhances the antiproliferative and apoptotic effects of adriamycin in MCF-7 breast tumor cells. Breast Cancer Research and Treatment. 63: 1-10. PMID 11079153 DOI: 10.1023/A:1006420708806 |
0.614 |
|
| 2001 |
Gewirtz DA. Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage. Breast Cancer Research and Treatment. 62: 223-35. PMID 11072787 DOI: 10.1023/A:1006414422919 |
0.578 |
|
| 1999 |
Jain PT, Seth P, Gewirtz DA. Estradiol enhances liposome-mediated uptake, preferential nuclear accumulation and functional expression of exogenous genes in MDA-MB231 breast tumor cells. Biochimica Et Biophysica Acta. 1451: 224-32. PMID 10556577 DOI: 10.1016/S0167-4889(99)00094-4 |
0.476 |
|
| 1999 |
Sundaram S, Gewirtz DA. The vitamin D3 analog EB 1089 enhances the response of human breast tumor cells to radiation Radiation Research. 152: 479-486. PMID 10521924 DOI: 10.2307/3580143 |
0.547 |
|
| 1999 |
Jain PT, Gewirtz DA. Sustained enhancement of liposome-mediated gene delivery and gene expression in human breast tumour cells by ionizing radiation. International Journal of Radiation Biology. 75: 217-23. PMID 10072183 DOI: 10.1080/095530099140672 |
0.34 |
|
| 1999 |
Jain PT, Gewirtz DA. Enhancement of liposomal gene delivery in human breast cancer cells by dimethyl sulfoxide. International Journal of Molecular Medicine. 1: 609-11. PMID 9852273 DOI: 10.3892/IJMM.1.3.609 |
0.342 |
|
| 1998 |
Jain PT, Gewirtz DA. Estradiol enhances gene delivery to human breast tumor cells. Journal of Molecular Medicine (Berlin, Germany). 76: 709-14. PMID 9766849 DOI: 10.1007/S001090050271 |
0.467 |
|
| 1998 |
Jain PT, Fornari FA, Randolph JK, Orr MS, Gewirtz DA. Induction of DNA damage, inhibition of DNA synthesis, and suppression of c-myc expression by the topoisomerase I inhibitor, camptothecin, in MCF-7 human breast tumor cells Biochemical Pharmacology. 55: 1263-1269. PMID 9719482 DOI: 10.1016/S0006-2952(97)00618-7 |
0.431 |
|
| 1998 |
Gewirtz DA, Randolph JK, Chawla J, Orr MS, Fornari FA. Induction of DNA damage, inhibition of DNA synthesis and suppression of c-myc expression by the anthracycline analog, idarubicin (4-demethoxy-daunorubicin) in the MCF-7 breast tumor cell line Cancer Chemotherapy and Pharmacology. 41: 361-369. PMID 9523731 DOI: 10.1007/S002800050752 |
0.476 |
|
| 1997 |
Watson NC, Di YM, Orr MS, Fornari J, Randolph JK, Magnet KJ, Jain PT, Gewirtz DA. Influence of ionizing radiation on proliferation, c-myc expression and the induction of apoptotic cell death in two breast tumour cell lines differing in p53 status International Journal of Radiation Biology. 72: 547-559. PMID 9374435 DOI: 10.1080/095530097143059 |
0.573 |
|
| 1997 |
Orr MS, Watson NC, Sundaram S, Randolph JK, Jain PT, Gewirtz DA. Ionizing radiation and teniposide increase p21(waf1/cip1) and promote Rb dephosphorylation but fail to suppress E2F activity in MCF-7 breast tumor cells Molecular Pharmacology. 52: 373-379. PMID 9281598 DOI: 10.1124/Mol.52.3.373 |
0.557 |
|
| 1996 |
Fornari FA, Jarvis WD, Grant S, Orr MS, Randolph JK, White FKH, Gewirtz DA. Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin Biochemical Pharmacology. 51: 931-940. PMID 8651943 DOI: 10.1016/0006-2952(96)00050-0 |
0.493 |
|
| 1996 |
Watson NC, Jarvis WD, Orr MS, Grant S, Gewirtz DA. Radiosensitization of HL-60 human leukaemia cells by bryostatin-1 in the absence of increased DNA fragmentation or apoptotic cell death. International Journal of Radiation Biology. 69: 183-92. PMID 8609454 DOI: 10.1080/095530096146011 |
0.534 |
|
| 1995 |
Orr MS, Fornari FA, Randolph JK, Gewirtz DA. Transcriptional down-regulation of c-myc expression in the MCF-7 breast tumor cell line by the topoisomerase 11 inhibitor, VM-26 Bba - Gene Structure and Expression. 1262: 139-145. PMID 7599188 DOI: 10.1016/0167-4781(95)00064-N |
0.381 |
|
| 1994 |
Bunch RT, Povirk LF, Orr MS, Randolph JK, Fornari FA, Gewirtz DA. Influence of amsacrine (m-AMSA) on bulk and gene-specific DNA damage and c-myc expression in MCF-7 breast tumor cells Biochemical Pharmacology. 47: 317-329. PMID 8304976 DOI: 10.1016/0006-2952(94)90023-X |
0.373 |
|
| 1994 |
Jarvis WD, Kolesnick RN, Fornari FA, Traylor RS, Gewirtz DA, Grant S. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proceedings of the National Academy of Sciences of the United States of America. 91: 73-7. PMID 8278410 DOI: 10.1073/Pnas.91.1.73 |
0.321 |
|
| 1994 |
Woods KE, Randolph JK, Gewirtz DA. Antagonism between tamoxifen and doxorubicin in the MCF-7 human breast tumor cell line. Biochemical Pharmacology. 47: 1449-52. PMID 8185652 DOI: 10.1016/0006-2952(94)90346-8 |
0.447 |
|
| 1994 |
David Jarvis W, Povirk LF, Turner AJ, Traylor RS, Gewirtz DA, Pettit GR, Grant S. Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-d-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells Biochemical Pharmacology. 47: 839-852. PMID 8135859 DOI: 10.1016/0006-2952(94)90484-7 |
0.381 |
|
| 1994 |
Woods KE, Grant S, Yanovich S, Gewirtz DA. Variable effects of tamoxifen on human hematopoietic progenitor cell growth and sensitivity to doxorubicin. Cancer Chemotherapy and Pharmacology. 33: 509-14. PMID 7511065 DOI: 10.1007/Bf00686510 |
0.427 |
|
| 1993 |
Wazer DE, Joyce M, Chan W, Gewirtz D, Lin P, Solares G, Schmidt-Ullrich RK. Effects of Tamoxifen on the Radiosensitivity of Hormonally Responsive and Unresponsive Breast Carcinoma Cells Radiation Oncology Investigations. 1: 20-28. DOI: 10.1002/Roi.2970010105 |
0.524 |
|
| 1990 |
Ellis AL, Randolph JK, Conway BR, Gewirtz DA. Biochemical lesions in DNA associated with the antiproliferative effects of mitoxantrone in the hepatoma cell. Biochemical Pharmacology. 39: 1549-56. PMID 2337411 DOI: 10.1016/0006-2952(90)90520-U |
0.353 |
|
| 1985 |
Gewirtz DA, Holt SA. Protein binding as a component of drug interaction in cellular pharmacokinetic studies. Effects of probenecid on transport and accumulation of methotrexate in Ehrlich ascites tumor cells in vitro. Biochemical Pharmacology. 34: 747-54. PMID 3977951 DOI: 10.1016/0006-2952(85)90753-1 |
0.41 |
|
| 1983 |
Fry DW, Gewirtz DA, Yalowich JC, Goldman ID. Characteristics of the accumulation of methotrexate polyglutamate derivatives in Ehrlich ascites tumor cells and isolated rat hepatocytes. Advances in Experimental Medicine and Biology. 163: 215-34. PMID 6193686 DOI: 10.1007/978-1-4757-5241-0_17 |
0.429 |
|
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