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Dewey G. McCafferty - Publications

Affiliations: 
Chemistry Duke University, Durham, NC 
Area:
chemical biology, mechanistic enzymology and molecular medicine
Website:
http://fds.duke.edu/db/aas/Chemistry/dewey
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Morgan KT, Zheng J, McCafferty D. Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin. Chembiochem : a European Journal of Chemical Biology. PMID 32805078 DOI: 10.1002/Cbic.202000555  0.446
2020 Hatstat AK, McCafferty DG. Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli. Protein Expression and Purification. 105649. PMID 32334140 DOI: 10.1016/J.Pep.2020.105649  0.36
2019 Dudiak BM, Maksimchuk KR, Bednar MM, Podracky CJ, Burg JM, Nguyen TM, Nwogbo FO, Valdivia RH, McCafferty DG. Insights into the Autoproteolytic Processing and Catalytic Mechanism of the Virulence-Associated Protease CPAF. Biochemistry. PMID 31386347 DOI: 10.1021/Acs.Biochem.9B00522  0.591
2016 Biniossek ML, Niemer M, Maksimchuk K, Mayer B, Fuchs J, Huesgen PF, McCafferty DG, Turk B, Fritz G, Mayer J, Haecker G, Mach L, Schilling O. Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics. Molecular & Cellular Proteomics : McP. PMID 27122596 DOI: 10.1074/Mcp.O115.056671  0.346
2016 Maksimchuk KR, Alser KA, Mou R, Valdivia RH, McCafferty DG. The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. Plos One. 11: e0147233. PMID 26829550 DOI: 10.1371/Journal.Pone.0147233  0.3
2015 Burg JM, Gonzalez JJ, Maksimchuk KR, McCafferty DG. Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones. Biochemistry. PMID 26673564 DOI: 10.1021/Acs.Biochem.5B01135  0.328
2015 Burg JM, Makhoul AT, Pemble CW, Link JE, Heller FJ, McCafferty DG. A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity. Febs Letters. 589: 2340-6. PMID 26226427 DOI: 10.1016/J.Febslet.2015.07.028  0.315
2015 Burg JM, Link JE, Morgan BS, Heller FJ, Hargrove AE, McCafferty DG. KDM1 Class Flavin-Dependent Protein Lysine Demethylases. Biopolymers. PMID 25787087 DOI: 10.1002/Bip.22643  0.376
2014 Snavely EA, Kokes M, Dunn JD, Saka HA, Nguyen BD, Bastidas RJ, McCafferty DG, Valdivia RH. Reassessing the role of the secreted protease CPAF in Chlamydia trachomatis infection through genetic approaches. Pathogens and Disease. 71: 336-51. PMID 24838663 DOI: 10.1111/2049-632X.12179  0.342
2013 Qi Y, Amiram M, Gao W, McCafferty DG, Chilkoti A. Sortase-catalyzed initiator attachment enables high yield growth of a stealth polymer from the C terminus of a protein. Macromolecular Rapid Communications. 34: 1256-60. PMID 23836349 DOI: 10.1002/Marc.201300460  0.306
2013 McCafferty DG, Melvin JA. Sortases Handbook of Proteolytic Enzymes. 2: 2459-2465. DOI: 10.1016/B978-0-12-382219-2.00549-4  0.663
2012 Folk DS, Torosian JC, Hwang S, McCafferty DG, Franz KJ. Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe. Angewandte Chemie (International Ed. in English). 51: 10795-9. PMID 23023944 DOI: 10.1002/Anie.201206673  0.512
2012 Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners. Acs Chemical Biology. 7: 1221-31. PMID 22533360 DOI: 10.1021/Cb300108C  0.605
2012 Hoertz AJ, Hamburger JB, Gooden DM, Bednar MM, McCafferty DG. Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2. Bioorganic & Medicinal Chemistry. 20: 859-65. PMID 22222159 DOI: 10.1016/J.Bmc.2011.11.062  0.739
2011 Bednar MM, Jorgensen I, Valdivia RH, McCafferty DG. Chlamydia protease-like activity factor (CPAF): characterization of proteolysis activity in vitro and development of a nanomolar affinity CPAF zymogen-derived inhibitor. Biochemistry. 50: 7441-3. PMID 21830778 DOI: 10.1021/Bi201098R  0.638
2011 Melvin JA, Murphy CF, Dubois LG, Thompson JW, Moseley MA, McCafferty DG. Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation. Biochemistry. 50: 7591-9. PMID 21812416 DOI: 10.1021/Bi200844H  0.729
2011 Jorgensen I, Bednar MM, Amin V, Davis BK, Ting JP, McCafferty DG, Valdivia RH. The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. Cell Host & Microbe. 10: 21-32. PMID 21767809 DOI: 10.1016/J.Chom.2011.06.008  0.639
2011 Hu X, Hu H, Melvin JA, Clancy KW, McCafferty DG, Yang W. Autocatalytic intramolecular isopeptide bond formation in gram-positive bacterial pili: a QM/MM simulation. Journal of the American Chemical Society. 133: 478-85. PMID 21142157 DOI: 10.1021/Ja107513T  0.753
2011 Hwang S, Schmitt AA, Luteran AE, Toone EJ, McCafferty DG. Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST. Biochemistry. 50: 546-57. PMID 21142040 DOI: 10.1021/Bi101776T  0.546
2010 Schmidt JW, Greenough A, Burns M, Luteran AE, McCafferty DG. Generation of ramoplanin-resistant Staphylococcus aureus. Fems Microbiology Letters. 310: 104-11. PMID 20659164 DOI: 10.1111/J.1574-6968.2010.02051.X  0.355
2010 Clancy KW, Melvin JA, McCafferty DG. Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition. Biopolymers. 94: 385-96. PMID 20593474 DOI: 10.1002/Bip.21472  0.775
2010 Clancy KW, Melvin JA, McCafferty DG. Erratum: Invited Review: Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibition Biopolymers. 94: 681-681. DOI: 10.1002/Bip.21529  0.773
2009 Hamburger JB, Hoertz AJ, Lee A, Senturia RJ, McCafferty DG, Loll PJ. A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface. Proceedings of the National Academy of Sciences of the United States of America. 106: 13759-64. PMID 19666597 DOI: 10.1073/Pnas.0904686106  0.73
2009 Gaweska H, Henderson Pozzi M, Schmidt DM, McCafferty DG, Fitzpatrick PF. Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1. Biochemistry. 48: 5440-5. PMID 19408960 DOI: 10.1021/Bi900499W  0.3
2009 Kudryavtsev KV, Bentley ML, McCafferty DG. Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform. Bioorganic & Medicinal Chemistry. 17: 2886-93. PMID 19269184 DOI: 10.1016/J.Bmc.2009.02.008  0.364
2009 Race PR, Bentley ML, Melvin JA, Crow A, Hughes RK, Smith WD, Sessions RB, Kehoe MA, McCafferty DG, Banfield MJ. Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism. The Journal of Biological Chemistry. 284: 6924-33. PMID 19129180 DOI: 10.1074/Jbc.M805406200  0.729
2008 Bentley ML, Lamb EC, McCafferty DG. Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus. The Journal of Biological Chemistry. 283: 14762-71. PMID 18375951 DOI: 10.1074/Jbc.M800974200  0.361
2008 Gooden DM, Schmidt DM, Pollock JA, Kabadi AM, McCafferty DG. Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. Bioorganic & Medicinal Chemistry Letters. 18: 3047-51. PMID 18242989 DOI: 10.1016/J.Bmcl.2008.01.003  0.634
2007 Frankel BA, Tong Y, Bentley ML, Fitzgerald MC, McCafferty DG. Mutational analysis of active site residues in the Staphylococcus aureus transpeptidase SrtA. Biochemistry. 46: 7269-78. PMID 17518446 DOI: 10.1021/Bi700448E  0.333
2007 Schmidt DM, McCafferty DG. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 46: 4408-16. PMID 17367163 DOI: 10.1021/Bi0618621  0.349
2007 Bentley ML, Gaweska H, Kielec JM, McCafferty DG. Engineering the substrate specificity of Staphylococcus aureus Sortase A. The beta6/beta7 loop from SrtB confers NPQTN recognition to SrtA. The Journal of Biological Chemistry. 282: 6571-81. PMID 17200112 DOI: 10.1074/Jbc.M610519200  0.312
2006 McCafferty DG. Crossing a biological velvet rope. Acs Chemical Biology. 1: 339-40. PMID 17163767 DOI: 10.1021/Cb6002948  0.301
2005 Frankel BA, Kruger RG, Robinson DE, Kelleher NL, McCafferty DG. Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism. Biochemistry. 44: 11188-200. PMID 16101303 DOI: 10.1021/Bi050141J  0.476
2004 Gaweska H, Kielec J, McCafferty D. A suppression strategy for antibiotic discovery Chemistry and Biology. 11: 1330-1332. PMID 15489159 DOI: 10.1016/J.Chembiol.2004.09.007  0.308
2004 Kruger RG, Barkallah S, Frankel BA, McCafferty DG. Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics. Bioorganic & Medicinal Chemistry. 12: 3723-9. PMID 15186858 DOI: 10.1016/J.Bmc.2004.03.066  0.391
2004 Striplin DR, Reece SY, McCafferty DG, Wall CG, Friesen DA, Erickson BW, Meyer TJ. Solvent dependence of intramolecular electron transfer in a helical oligoproline assembly. Journal of the American Chemical Society. 126: 5282-91. PMID 15099113 DOI: 10.1021/Ja0304289  0.55
2004 Frankel BA, Bentley M, Kruger RG, McCafferty DG. Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus. Journal of the American Chemical Society. 126: 3404-5. PMID 15025450 DOI: 10.1021/Ja0390294  0.34
2004 Kruger RG, Dostal P, McCafferty DG. Development of a high-performance liquid chromatography assay and revision of kinetic parameters for the Staphylococcus aureus sortase transpeptidase SrtA. Analytical Biochemistry. 326: 42-8. PMID 14769334 DOI: 10.1016/J.Ab.2003.10.023  0.364
2004 Kruger RG, Otvos B, Frankel BA, Bentley M, Dostal P, McCafferty DG. Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA. Biochemistry. 43: 1541-51. PMID 14769030 DOI: 10.1021/Bi035920J  0.454
2003 He S, Bauman D, Davis JS, Loyola A, Nishioka K, Gronlund JL, Reinberg D, Meng F, Kelleher N, McCafferty DG. Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 12033-8. PMID 14530408 DOI: 10.1073/Pnas.2035256100  0.482
2003 Kapustin GV, Fejér G, Gronlund JL, McCafferty DG, Seto E, Etzkorn FA. Phosphorus-based SAHA analogues as histone deacetylase inhibitors. Organic Letters. 5: 3053-6. PMID 12916979 DOI: 10.1021/Ol035056N  0.628
2002 McCafferty DG, Cudic P, Frankel BA, Barkallah S, Kruger RG, Li W. Chemistry and biology of the ramoplanin family of peptide antibiotics. Biopolymers. 66: 261-84. PMID 12491539 DOI: 10.1002/Bip.10296  0.734
2002 Kruger RG, Dostal P, McCafferty DG. An economical and preparative orthogonal solid phase synthesis of fluorescein and rhodamine derivatized peptides: FRET substrates for the Staphylococcus aureus sortase SrtA transpeptidase reaction. Chemical Communications (Cambridge, England). 2092-3. PMID 12357793 DOI: 10.1039/B206303D  0.339
2002 Cudic P, Behenna DC, Kranz JK, Kruger RG, Wand AJ, Veklich YI, Weisel JW, McCafferty DG. Functional analysis of the lipoglycodepsipeptide antibiotic ramoplanin. Chemistry & Biology. 9: 897-906. PMID 12204689 DOI: 10.1016/S1074-5521(02)00191-6  0.739
2002 Cudic P, Kranz JK, Behenna DC, Kruger RG, Tadesse H, Wand AJ, Veklich YI, Weisel JW, McCafferty DG. Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation. Proceedings of the National Academy of Sciences of the United States of America. 99: 7384-9. PMID 12032292 DOI: 10.1073/Pnas.102192099  0.709
2001 Cudic P, Behenna DC, Yu MK, Kruger RG, Szewczuk LM, McCafferty DG. Synthesis of P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG. Bioorganic & Medicinal Chemistry Letters. 11: 3107-10. PMID 11720853 DOI: 10.1016/S0960-894X(01)00653-9  0.634
2000 Bishop BM, McCafferty DG, Erickson BW. 4'-Aminomethyl-2,2'-bipyridyl-4-carboxylic acid (Abc) and related derivatives: Novel bipyridine amino acids for the solid-phase incorporation of a metal coordination site within a peptide backbone Tetrahedron. 56: 4629-4638. DOI: 10.1016/S0040-4020(00)00367-7  0.584
1999 McCafferty DG, Cudic P, Yu MK, Behenna DC, Kruger R. Synergy and duality in peptide antibiotic mechanisms. Current Opinion in Chemical Biology. 3: 672-80. PMID 10600730 DOI: 10.1016/S1367-5931(99)00025-3  0.711
1998 Lessard IA, Pratt SD, McCafferty DG, Bussiere DE, Hutchins C, Wanner BL, Katz L, Walsh CT. Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. Chemistry & Biology. 5: 489-504. PMID 9751644 DOI: 10.1016/S1074-5521(98)90005-9  0.457
1997 McCafferty DG, Lessard IA, Walsh CT. Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. Biochemistry. 36: 10498-505. PMID 9265630 DOI: 10.1021/Bi970543U  0.49
1996 McCafferty DG, Friesen DA, Danielson E, Wall CG, Saderholm MJ, Erickson BW, Meyer TJ. Photochemical energy conversion in a helical oligoproline assembly. Proceedings of the National Academy of Sciences of the United States of America. 93: 8200-4. PMID 8710847 DOI: 10.1073/Pnas.93.16.8200  0.75
1995 McCafferty DG, Slate CA, Nakhle BM, Graham HD, Austell TL, Vachet RW, Mullis BH, Erickson BW. Engineering of a 129-residue tripod protein by chemoselective ligation of proline-II helices Tetrahedron. 51: 9859-9872. DOI: 10.1016/0040-4020(95)00592-V  0.597
1995 McCafferty DG, Bishop BM, Wall CG, Hughes SG, Mecklenberg SL, Meyer TJ, Erickson BW. Synthesis of redox derivatives of lysine and their use in solid-phase synthesis of a light-harvesting peptide Tetrahedron. 51: 1093-1106. DOI: 10.1016/0040-4020(94)01018-U  0.594
1994 Mecklenburg SL, McCafferty DG, Schoonover JR, Peek BM, Erickson BW, Meyer TJ. Spectroscopic Study of Electron Transfer in a Trifunctional Lysine with Anthraquinone as the Electron Acceptor Inorganic Chemistry. 33: 2974-2983. DOI: 10.1021/Ic00091A042  0.551
1994 Mecklenburg SL, McCafferty DG, Schoonover JR, Peek BM, Erickson BW, Meyer TJ. Spectroscopic study of electron transfer in a trifunctional lysine with anthraquinone as the electron acceptor Inorganic Chemistry. 33: 2974-2983.  0.476
1993 Mecklenburg SL, Peek BM, Schoonover JR, McCafferty DG, Wall CG, Erickson BW, Meyer TJ. Photoinduced Electron Transfer in Amino Acid Assemblies Journal of the American Chemical Society. 115: 5479-5495. DOI: 10.1021/Ja00066A017  0.558
1993 Mecklenburg SL, Peek BM, Schoonover JR, McCafferty DG, Wall CG, Erickson BW, Meyer TJ. Photoinduced electron transfer in amino acid assemblies Journal of the American Chemical Society. 115: 5479-5495.  0.496
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