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Joshua R. Sacher, Ph.D. - Publications

Affiliations: 
2014- Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard, USA 
Area:
chemistry, synthesis, organic chemistry, medicinal chemistry, neuroscience
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13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wagner FF, Benajiba L, Campbell AJ, Weïwer M, Sacher JR, Gale JP, Ross L, Puissant A, Alexe G, Conway A, Back M, Pikman Y, Galinsky I, DeAngelo DJ, Stone RM, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Science Translational Medicine. 10. PMID 29515000 DOI: 10.1126/Scitranslmed.Aam8460  0.301
2017 Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS. Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In Vivo (Athens, Greece). 31: 39-43. PMID 28064218 DOI: 10.21873/Invivo.11022  0.417
2016 Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P. A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. Acs Central Science. 2: 653-659. PMID 27725964 DOI: 10.1021/Acscentsci.6B00199  0.45
2015 Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 26159482 DOI: 10.1016/J.Bmcl.2015.06.073  0.445
2015 Chauhan PS, Sacher JR, Weinreb SM. Synthesis of the tetracyclic skeleton of the Lycopodium alkaloid lycopladine H via a pivotal double hydroformylation/intramolecular reductive amination sequence. Organic Letters. 17: 806-8. PMID 25658603 DOI: 10.1021/Ol503571A  0.53
2015 Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.06.073  0.365
2014 Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. Journal of Molecular and Cellular Cardiology. 77: 136-46. PMID 25451170 DOI: 10.1016/J.Yjmcc.2014.10.009  0.406
2014 Skoda EM, Sacher JR, Kazancioglu MZ, Saha J, Wipf P. An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility. Acs Medicinal Chemistry Letters. 5: 900-4. PMID 25147611 DOI: 10.1021/Ml5001504  0.39
2014 Sacher JR, Weinreb SM. DISCUSSION ADDENDUM for: 2‐Trimethylsilylethanesulfonyl Chloride (SES‐Cl) Organic Syntheses. 34-43. DOI: 10.1002/0471264229.Os089.03  0.434
2013 Frantz MC, Skoda EM, Sacher JR, Epperly MW, Goff JP, Greenberger JS, Wipf P. Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria. Organic & Biomolecular Chemistry. 11: 4147-53. PMID 23715589 DOI: 10.1039/C3Ob40489G  0.467
2012 Sacher JR, Weinreb SM. Construction of the azocane (azacyclooctane) moiety of the Lycopodium alkaloid lycopladine H via an intramolecular hydroaminomethylation strategy. Organic Letters. 14: 2172-5. PMID 22486178 DOI: 10.1021/Ol3007277  0.519
2011 Sacher JR, Weinreb SM. Exploratory studies towards a total synthesis of the unusual bridged tetracyclic Lycopodium alkaloid lycopladine H. Tetrahedron. 67: 10203-10207. PMID 22125345 DOI: 10.1016/J.Tet.2011.04.016  0.541
2009 Evans MA, Sacher JR, Weinreb SM. Exploratory studies toward a total synthesis of the marine ascidian metabolite perophoramidine Tetrahedron. 65: 6712-6719. DOI: 10.1016/J.Tet.2008.10.060  0.519
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