| Year |
Citation |
Score |
| 2018 |
Gunaratnam M, Collie GW, Reszka AP, Todd AK, Parkinson GN, Neidle S. A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line. Bioorganic & Medicinal Chemistry. PMID 29724653 DOI: 10.1016/J.Bmc.2018.04.050 |
0.577 |
|
| 2018 |
Marchetti C, Zyner KG, Ohnmacht SA, Robson M, Haider SM, Morton JP, Marsico G, Vo T, Laughlin-Toth S, Ahmed AA, Di Vita G, Pazitna I, Gunaratnam M, Besser RJ, Andrade AC, et al. Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule. Journal of Medicinal Chemistry. PMID 29356532 DOI: 10.1021/Acs.Jmedchem.7B01781 |
0.607 |
|
| 2015 |
Roe S, Gunaratnam M, Spiteri C, Sharma P, Alharthy RD, Neidle S, Moses JE. Synthesis and biological evaluation of hybrid acridine-HSP90 ligand conjugates as telomerase inhibitors. Organic & Biomolecular Chemistry. PMID 26156660 DOI: 10.1039/C5Ob01177A |
0.555 |
|
| 2015 |
Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Pedley RB, Hartley JA, Neidle S. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer. Scientific Reports. 5: 11385. PMID 26077929 DOI: 10.1038/Srep11385 |
0.591 |
|
| 2015 |
Marchetti C, Minarini A, Tumiatti V, Moraca F, Parrotta L, Alcaro S, Rigo R, Sissi C, Gunaratnam M, Ohnmacht SA, Neidle S, Milelli A. Macrocyclic naphthalene diimides as G-quadruplex binders. Bioorganic & Medicinal Chemistry. 23: 3819-30. PMID 25935290 DOI: 10.1016/J.Bmc.2015.03.076 |
0.659 |
|
| 2015 |
Lavrado J, Brito H, Borralho PM, Ohnmacht SA, Kim NS, Leitão C, Pisco S, Gunaratnam M, Rodrigues CM, Moreira R, Neidle S, Paulo A. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines. Scientific Reports. 5: 9696. PMID 25853628 DOI: 10.1038/Srep09696 |
0.636 |
|
| 2015 |
Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJ, Paulo A. Indolo[3,2-c]quinoline G-quadruplex stabilizers: a structural analysis of binding to the human telomeric G-quadruplex. Chemmedchem. 10: 836-49. PMID 25820698 DOI: 10.1002/Cmdc.201500067 |
0.583 |
|
| 2015 |
Ohnmacht SA, Marchetti C, Gunaratnam M, Besser RJ, Haider SM, Di Vita G, Lowe HL, Mellinas-Gomez M, Diocou S, Robson M, Šponer J, Islam B, Barbara Pedley R, Hartley JA, Neidle S. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer Scientific Reports. 5. DOI: 10.1038/srep11385 |
0.562 |
|
| 2015 |
Marchetti C, Minarini A, Tumiatti V, Moraca F, Parrotta L, Alcaro S, Rigo R, Sissi C, Gunaratnam M, Ohnmacht SA, Neidle S, Milelli A. Macrocyclic naphthalene diimides as G-quadruplex binders Bioorganic and Medicinal Chemistry. 23: 3819-3830. DOI: 10.1016/j.bmc.2015.03.076 |
0.476 |
|
| 2015 |
Lavrado J, Ohnmacht SA, Correia I, Leitão C, Pisco S, Gunaratnam M, Moreira R, Neidle S, Santos DJVAD, Paulo A. Indolo[3,2-c]quinoline G-quadruplex stabilizers: A structural analysis of binding to the human telomeric G-quadruplex Chemmedchem. 10: 836-849. DOI: 10.1002/cmdc.201500067 |
0.516 |
|
| 2014 |
Ohnmacht SA, Varavipour E, Nanjunda R, Pazitna I, Di Vita G, Gunaratnam M, Kumar A, Ismail MA, Boykin DW, Wilson WD, Neidle S. Discovery of new G-quadruplex binding chemotypes. Chemical Communications (Cambridge, England). 50: 960-3. PMID 24302123 DOI: 10.1039/C3Cc48616H |
0.622 |
|
| 2013 |
Wei D, Todd AK, Zloh M, Gunaratnam M, Parkinson GN, Neidle S. Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex Journal of the American Chemical Society. 135: 19319-19329. PMID 24295054 DOI: 10.1021/Ja4101358 |
0.517 |
|
| 2013 |
Shiu WK, Malkinson JP, Rahman MM, Curry J, Stapleton P, Gunaratnam M, Neidle S, Mushtaq S, Warner M, Livermore DM, Evangelopoulos D, Basavannacharya C, Bhakta S, Schindler BD, Seo SM, et al. A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus. International Journal of Antimicrobial Agents. 42: 513-8. PMID 24119569 DOI: 10.1016/J.Ijantimicag.2013.08.007 |
0.49 |
|
| 2013 |
Ohnmacht SA, Ciancimino C, Vignaroli G, Gunaratnam M, Neidle S. Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands Bioorganic and Medicinal Chemistry Letters. 23: 5351-5355. PMID 23972440 DOI: 10.1016/J.Bmcl.2013.07.057 |
0.632 |
|
| 2013 |
Mpima S, Ohnmacht SA, Barletta M, Husby J, Pett LC, Gunaratnam M, Hilton ST, Neidle S. The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds. Bioorganic & Medicinal Chemistry. 21: 6162-70. PMID 23769166 DOI: 10.1016/J.Bmc.2013.05.027 |
0.598 |
|
| 2013 |
Micco M, Collie GW, Dale AG, Ohnmacht SA, Pazitna I, Gunaratnam M, Reszka AP, Neidle S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. Journal of Medicinal Chemistry. 56: 2959-74. PMID 23514618 DOI: 10.1021/Jm301899Y |
0.671 |
|
| 2013 |
Baud MG, Leiser T, Petrucci V, Gunaratnam M, Neidle S, Meyer-Almes FJ, Fuchter MJ. Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors. Beilstein Journal of Organic Chemistry. 9: 81-8. PMID 23400330 DOI: 10.3762/Bjoc.9.11 |
0.564 |
|
| 2013 |
Baud MGJ, Leiser T, Petrucci V, Gunaratnam M, Neidle S, Meyer-Almes FJ, Fuchter MJ. Thioester derivatives of the natural product psammaplin A as potent histone deacetylase inhibitors Beilstein Journal of Organic Chemistry. 9: 81-88. DOI: 10.3762/bjoc.9.11 |
0.398 |
|
| 2012 |
Ohnmacht SA, Micco M, Petrucci V, Todd AK, Reszka AP, Gunaratnam M, Carvalho MA, Zloh M, Neidle S. Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives Bioorganic and Medicinal Chemistry Letters. 22: 5930-5935. PMID 22892119 DOI: 10.1016/J.Bmcl.2012.07.065 |
0.609 |
|
| 2012 |
Rahman KM, Hossain MD, Sohrab MH, Drake AF, Bui TT, Husby J, Gunaratnam M, Neidle S, Hasan CM, Thurston DE. The prenylated dioxopiperazine alkaloid Cristatin A has selective telomeric DNA G-quadruplex stabilising properties Chemical Communications. 48: 8760-8762. PMID 22836516 DOI: 10.1039/C2Cc31277H |
0.576 |
|
| 2012 |
Wangteeraprasert R, Lipipun V, Gunaratnam M, Neidle S, Gibbons S, Likhitwitayawuid K. Bioactive compounds from Carissa spinarum Phytotherapy Research. 26: 1496-1499. PMID 22308099 DOI: 10.1002/Ptr.4607 |
0.528 |
|
| 2012 |
Baud MGJ, Leiser T, Haus P, Samlal S, Wong AC, Wood RJ, Petrucci V, Gunaratnam M, Hughes SM, Buluwela L, Turlais F, Neidle S, Meyer-Almes FJ, White AJP, Fuchter MJ. Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets Journal of Medicinal Chemistry. 55: 1731-1750. PMID 22280363 DOI: 10.1021/Jm2016182 |
0.573 |
|
| 2012 |
Campbell NH, Karim NHA, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle S. Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes Journal of Medicinal Chemistry. 55: 209-222. PMID 22112241 DOI: 10.1021/Jm201140V |
0.565 |
|
| 2012 |
Micco M, Collie G, Gunaratnam M, Ohnmacht SA, Reszka AP, Neidle S. Abstract LB-2: Structure-based design of G-quadruplex ligands leads to enhanced potency against pancreatic cancer cells Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-2 |
0.656 |
|
| 2011 |
Gunaratnam M, Fuente MDL, Hampel SM, Todd AK, Reszka AP, Schätzlein A, Neidle S. Targeting pancreatic cancer with a G-quadruplex ligand Bioorganic and Medicinal Chemistry. 19: 7151-7157. PMID 22041170 DOI: 10.1016/J.Bmc.2011.09.055 |
0.667 |
|
| 2011 |
Parkinson GN, Gunaratnam M, Li XW, Collie G, Reszka AP, Todd AR, Fletcher JA, Neidle S. Abstract 2310: Down-regulating BCL-2 gene expression in a resistant GIST cell line by a RNA G-quadruplex interacting small molecule ligand Cancer Research. 71: 2310-2310. DOI: 10.1158/1538-7445.Am2011-2310 |
0.611 |
|
| 2011 |
Fuchter MJ, Baud MGJ, Leiser T, Samlal S, Wong AC, Wood RJ, Gunaratnam M, Hughes SM, Buluwela L, Turlais F, Neidle S, Meyer-Almes F. Abstract B166: Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B166 |
0.604 |
|
| 2010 |
Bejugam M, Gunaratnam M, Müller S, Sanders DA, Sewitz S, Fletcher JA, Neidle S, Balasubramanian S. Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines. Acs Medicinal Chemistry Letters. 1: 306-10. PMID 24900212 DOI: 10.1021/Ml100062Z |
0.613 |
|
| 2010 |
Hampel SM, Sidibe A, Gunaratnam M, Riou JF, Neidle S. Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells Bioorganic and Medicinal Chemistry Letters. 20: 6459-6463. PMID 20932753 DOI: 10.1016/J.Bmcl.2010.09.066 |
0.683 |
|
| 2010 |
Sparapani S, Haider SM, Doria F, Gunaratnam M, Neidle S. Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes Journal of the American Chemical Society. 132: 12263-12272. PMID 20718414 DOI: 10.1021/Ja1003944 |
0.656 |
|
| 2010 |
Sparapani S, Bellini S, Gunaratnam M, Haider SM, Andreani A, Rambaldi M, Locatelli A, Morigi R, Granaiola M, Varoli L, Burnelli S, Leoni A, Neidle S. Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Chemical Communications (Cambridge, England). 46: 5680-2. PMID 20582382 DOI: 10.1039/C0Cc00020E |
0.595 |
|
| 2010 |
Gunaratnam M, Neidle S. An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells. Methods in Molecular Biology (Clifton, N.J.). 613: 303-313. PMID 19997892 DOI: 10.1007/978-1-60327-418-0_19 |
0.634 |
|
| 2010 |
Hampel S, Gunaratnam M, Fuente Mdl, Schatzlein A, Neidle S. Abstract 739: Targeting pancreatic cancers with a quadruplex-binding small molecule Cancer Research. 70: 739-739. DOI: 10.1158/1538-7445.Am10-739 |
0.614 |
|
| 2010 |
Gunaratnam M, Collie G, Reszka A, Todd A, Parkinson G, Fletcher J, Neidle S. Abstract 3679: Targeting drug-resistant GIST cells with a quadruplex-binding small molecule Cancer Research. 70: 3679-3679. DOI: 10.1158/1538-7445.Am10-3679 |
0.631 |
|
| 2010 |
Bejugam M, Gunaratnam M, Müller S, Sanders DA, Sewitz S, Fletcher JA, Neidle S, Balasubramanian S. Correction to Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines Acs Medicinal Chemistry Letters. 1: 546-546. DOI: 10.1021/Ml100241W |
0.523 |
|
| 2010 |
Bejugam M, Gunaratnam M, Müller S, Sanders DA, Sewitz S, Fletcher JA, Neidle S, Balasubramanian S. Targeting the c-Kit promoter g-quadruplexes with 6-substituted indenoisoquinolines Acs Medicinal Chemistry Letters. 1: 306-310. DOI: 10.1021/ml100062z |
0.487 |
|
| 2009 |
Rahman KM, Reszka AP, Gunaratnam M, Haider SM, Howard PW, Fox KR, Neidle S, Thurston DE. Biaryl polyamides as a new class of DNA quadruplex-binding ligands Chemical Communications. 4097-4099. PMID 19568645 DOI: 10.1039/B902359C |
0.614 |
|
| 2009 |
Gunaratnam M, Green C, Moreira JB, Moorhouse AD, Kelland LR, Moses JE, Neidle S. G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo. Biochemical Pharmacology. 78: 115-22. PMID 19475728 DOI: 10.1016/J.Bcp.2009.03.018 |
0.606 |
|
| 2009 |
Gunaratnam M, Swank S, Haider SM, Galesa K, Reszka AP, Beltran M, Cuenca F, Fletcher JA, Neidle S. Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule Journal of Medicinal Chemistry. 52: 3774-3783. PMID 19469547 DOI: 10.1021/Jm900424A |
0.575 |
|
| 2009 |
O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S. Bioactive pyridine-N-oxide disulfides from Allium stipitatum. Journal of Natural Products. 72: 360-5. PMID 19093848 DOI: 10.1021/Np800572R |
0.557 |
|
| 2008 |
Drewe WC, Nanjunda R, Gunaratnam M, Beltran M, Parkinson GN, Reszka AP, Wilson WD, Neidle S. Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. Journal of Medicinal Chemistry. 51: 7751-67. PMID 19053833 DOI: 10.1021/jm801245v |
0.585 |
|
| 2008 |
Reed J, Gunaratnam M, Beltran M, Reszka AP, Vilar R, Neidle S. TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. Analytical Biochemistry. 380: 99-105. PMID 18534183 DOI: 10.1016/J.Ab.2008.05.013 |
0.557 |
|
| 2008 |
Moorhouse AD, Haider S, Gunaratnam M, Munnur D, Neidle S, Moses JE. Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Molecular Biosystems. 4: 629-42. PMID 18493662 DOI: 10.1039/B801822G |
0.644 |
|
| 2008 |
Gunaratnam M, Grant MH. Cr (VI) inhibits DNA, RNA and protein syntheses in hepatocytes: involvement of glutathione reductase, reduced glutathione and DT-diaphorase. Toxicology in Vitro : An International Journal Published in Association With Bibra. 22: 879-86. PMID 18321676 DOI: 10.1016/J.Tiv.2008.01.005 |
0.309 |
|
| 2008 |
Cuenca F, Greciano O, Gunaratnam M, Haider S, Munnur D, Nanjunda R, Wilson WD, Neidle S. Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands Bioorganic and Medicinal Chemistry Letters. 18: 1668-1673. PMID 18243701 DOI: 10.1016/J.Bmcl.2008.01.050 |
0.667 |
|
| 2007 |
Gunaratnam M, Greciano O, Martins C, Reszka AP, Schultes CM, Morjani H, Riou JF, Neidle S. Mechanism of acridine-based telomerase inhibition and telomere shortening Biochemical Pharmacology. 74: 679-689. PMID 17631279 DOI: 10.1016/J.Bcp.2007.06.011 |
0.617 |
|
| 2007 |
Milroy LG, Zinzalla G, Prencipe G, Michel P, Ley SV, Gunaratnam M, Beltran M, Neidle S. Chemical variation of natural-product-like scaffolds: Design, synthesis, and biological activity of fused bicyclic acetal derivatives Angewandte Chemie - International Edition. 46: 2493-2496. PMID 17318936 DOI: 10.1002/Anie.200604688 |
0.48 |
|
| 2007 |
Martins C, Gunaratnam M, Stuart J, Makwana V, Greciano O, Reszka AP, Kelland LR, Neidle S. Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorganic & Medicinal Chemistry Letters. 17: 2293-8. PMID 17276687 DOI: 10.1016/J.Bmcl.2007.01.056 |
0.657 |
|
| 2006 |
Moorhouse AD, Santos AM, Gunaratnam M, Moore M, Neidle S, Moses JE. Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. Journal of the American Chemical Society. 128: 15972-3. PMID 17165715 DOI: 10.1021/Ja0661919 |
0.638 |
|
| 2006 |
Le Sann C, Baron A, Mann J, van den Berg H, Gunaratnam M, Neidle S. New mustard-linked 2-aryl-bis-benzimidazoles with anti-proliferative activity. Organic & Biomolecular Chemistry. 4: 1305-12. PMID 16557319 DOI: 10.1039/B600567E |
0.587 |
|
| 2006 |
Moore MJ, Schultes CM, Cuesta J, Cuenca F, Gunaratnam M, Tanious FA, Wilson WD, Neidle S. Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. Journal of Medicinal Chemistry. 49: 582-99. PMID 16420044 DOI: 10.1021/Jm050555A |
0.667 |
|
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