| Year |
Citation |
Score |
| 2023 |
Chowdhury NN, Yang Y, Dutta A, Luo M, Wei Z, Abrahams SR, Revenko AS, Shah F, Miles LA, Parmer RJ, de Laat B, Wolberg AS, Luyendyk JP, Fishel ML, Flick MJ. Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression. Molecular Oncology. PMID 37971174 DOI: 10.1002/1878-0261.13552 |
0.484 |
|
| 2023 |
Hur WS, Kawano T, Mwiza JMN, Paul DS, Lee RH, Clark EG, Bouck EG, Dutta A, Cai C, Baker SR, Guthold M, Mackman N, Mangin PH, Wolberg AS, Bergmeier W, ... Flick MJ, et al. Mice expressing nonpolymerizable fibrinogen have reduced arterial and venous thrombosis with preserved hemostasis. Blood. PMID 37832029 DOI: 10.1182/blood.2023020805 |
0.371 |
|
| 2023 |
Ballard-Kordeliski A, Lee RH, O'Shaughnessy EC, Kim PY, Jones S, Mackman N, Flick MJ, Paul DS, Adalsteinsson D, Bergmeier W. 4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse model of hemostasis. Biorxiv : the Preprint Server For Biology. PMID 37662350 DOI: 10.1101/2023.08.25.554449 |
0.318 |
|
| 2022 |
Hur WS, King KC, Patel YN, Nguyen YV, Wei Z, Yang Y, Juang LJ, Leung J, Kastrup CJ, Wolberg AS, Luyendyk JP, Flick MJ. Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies. Journal of Thrombosis and Haemostasis : Jth. PMID 36111375 DOI: 10.1111/jth.15877 |
0.322 |
|
| 2022 |
Lee RH, Ghalloussi D, Harousseau GL, Kenny JP, Kramer PA, Proamer F, Nieswandt B, Flick MJ, Gachet C, Casari C, Eckly A, Bergmeier W. Rasa3 deficiency minimally impacts thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance. Jci Insight. PMID 35290242 DOI: 10.1172/jci.insight.155676 |
0.328 |
|
| 2022 |
Negrón O, Hur WS, Prasad J, Paul DS, Rowe SE, Degen JL, Abrahams SR, Antoniak S, Conlon BP, Bergmeier W, Hӧӧk M, Flick MJ. Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection. Plos Pathogens. 18: e1010227. PMID 35041705 DOI: 10.1371/journal.ppat.1010227 |
0.571 |
|
| 2021 |
Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, ... Flick MJ, et al. Suppression of fibrin(ogen)-driven pathologies through controlled knockdown by lipid nanoparticle delivery of siRNA. Blood. PMID 34958662 DOI: 10.1182/blood.2021014559 |
0.352 |
|
| 2021 |
Hur WS, Paul DS, Bouck EG, Negron O, Mwiza JMN, Poole LG, Cline-Fedewa HM, Clark EG, Juang LJ, Leung J, Kastrup CJ, Ugarova TP, Wolberg AS, Luyendyk JP, Bergmeier W, ... Flick MJ, et al. Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with a Fga truncation mutation. Blood. PMID 34905618 DOI: 10.1182/blood.2021012537 |
0.379 |
|
| 2021 |
Henderson MW, Sparkenbaugh EM, Wang S, Ilich A, Noubouossie DF, Mailer RK, Renné T, Flick MJ, Luyendyk JP, Chen ZL, Strickland S, Stravitz RT, McCrae KR, Key NS, Pawlinski R. Plasmin-mediated Cleavage of High Molecular Weight Kininogen Contributes to Acetaminophen-Induced Acute Liver Failure. Blood. PMID 33827130 DOI: 10.1182/blood.2020006198 |
0.31 |
|
| 2021 |
Prasad JM, Negrón O, Du X, Mullins ES, Palumbo JS, Gilbertie JM, Höök M, Grover SP, Pawlinski R, Mackman N, Degen JL, Flick MJ. Host fibrinogen drives antimicrobial function in peritonitis through bacterial-mediated prothrombin activation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33443167 DOI: 10.1073/pnas.2009837118 |
0.621 |
|
| 2020 |
Choi SR, Yang Y, Huang KY, Kong HJ, Flick MJ, Han B. Engineering of biomaterials for tumor modeling. Materials Today. Advances. 8. PMID 34541484 DOI: 10.1016/j.mtadv.2020.100117 |
0.62 |
|
| 2020 |
Schweickert PG, Yang Y, White EE, Cresswell GM, Elzey BD, Ratliff TL, Arumugam P, Antoniak S, Mackman N, Flick MJ, Konieczny SF. Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment. Journal of Thrombosis and Haemostasis : Jth. PMID 33064371 DOI: 10.1111/jth.15115 |
0.733 |
|
| 2020 |
Rosell A, Moser B, Hisada Y, Chinthapatla R, Lian G, Yang Y, Flick MJ, Mackman N. Evaluation of different commercial antibodies for their ability to detect human and mouse tissue factor by western blotting. Research and Practice in Thrombosis and Haemostasis. 4: 1013-1023. PMID 32864552 DOI: 10.1002/rth2.12363 |
0.309 |
|
| 2020 |
Ni R, Neves MAD, Wu C, Cerroni SE, Flick MJ, Ni H, Weitz JI, Gross PL, Kim PY. Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates fibrin-dependent plasmin generation on thrombin-activated platelets. Journal of Thrombosis and Haemostasis : Jth. PMID 32506822 DOI: 10.1111/Jth.14950 |
0.328 |
|
| 2020 |
Miszta A, Kopec AK, Pant A, Holle L, Byrnes JR, Lawrence DA, Hansen K, Flick MJ, Luyendyk JP, de Laat B, Wolberg AS. High fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice. Blood. PMID 32315384 DOI: 10.1182/Blood.2019004267 |
0.314 |
|
| 2019 |
Anokhin BA, Dean WL, Smith KA, Flick MJ, Ariëns RAS, Philippou H, Maurer MC. Proteolytic and Nonproteolytic Activation Mechanisms Result in Conformationally and Functionally Different Forms of Coagulation Factor XIII A. The Febs Journal. PMID 31407850 DOI: 10.1111/Febs.15040 |
0.337 |
|
| 2019 |
Sharma BK, Flick MJ, Palumbo JS. Cancer-Associated Thrombosis: A Two-Way Street. Seminars in Thrombosis and Hemostasis. PMID 31382306 DOI: 10.1055/S-0039-1693472 |
0.302 |
|
| 2019 |
Negrón O, Flick MJ. Does fibrinogen serve the host or the microbe in Staphylococcus infection? Current Opinion in Hematology. 26: 343-348. PMID 31348048 DOI: 10.1097/Moh.0000000000000527 |
0.336 |
|
| 2019 |
Silva LM, Lum AG, Tran C, Shaw MW, Gao Z, Flick MJ, Moutsopoulos N, Bugge TH, Mullins ES. Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation. Blood. PMID 31101623 DOI: 10.1182/blood.2018874859 |
0.314 |
|
| 2019 |
Yang Y, Stang A, Schweickert PG, Lanman NA, Paul EN, Monia BP, Revenko AS, Palumbo JS, Mullins ES, Elzey BD, Janssen EM, Konieczny SF, Flick MJ. Thrombin signaling promotes pancreatic adenocarcinoma through PAR-1-dependent immune evasion. Cancer Research. PMID 31048498 DOI: 10.1158/0008-5472.Can-18-3206 |
0.772 |
|
| 2019 |
Shukla S, Milewski D, Pradhan A, Rama N, Rice K, Le T, Flick MJ, Vaz S, Zhao X, Setchell KD, Logarinho E, Kalinichenko VV, Kalin TV. The FOXM1 inhibitor RCM-1 decreases carcinogenesis and nuclear β-catenin. Molecular Cancer Therapeutics. PMID 31040162 DOI: 10.1158/1535-7163.Mct-18-0709 |
0.368 |
|
| 2019 |
Landers CT, Tung HY, Knight JM, Madison MC, Wu Y, Zeng Z, Porter PC, Rodriguez A, Flick MJ, Kheradmand F, Corry DB. Selective fibrinogen cleavage by diverse proteinases initiates innate allergic and antifungal immunity through CD11b. The Journal of Biological Chemistry. PMID 30992366 DOI: 10.1074/Jbc.Ra118.006724 |
0.304 |
|
| 2019 |
Sharma B, Mureb D, Murab S, Rosenfeldt LA, Francisco BJ, Boucher AA, Cantrell R, Mast J, Flick MJ, Whitlock PW, Palumbo JS. Fibrinogen Activates FAK to Promote the Colorectal Adenocarcinoma Growth Blood. 134: 1111-1111. DOI: 10.1182/Blood-2019-130497 |
0.364 |
|
| 2018 |
Luyendyk JP, Schoenecker JG, Flick MJ. The multifaceted role of fibrinogen in tissue injury and inflammation. Blood. PMID 30523120 DOI: 10.1182/Blood-2018-07-818211 |
0.327 |
|
| 2018 |
Stagaard R, Ley CD, Almholt K, Olsen LH, Knudsen T, Flick MJ. Absence of functional compensation between coagulation factor VIII and plasminogen in double-knockout mice. Blood Advances. 2: 3126-3136. PMID 30459211 DOI: 10.1182/Bloodadvances.2018024851 |
0.448 |
|
| 2018 |
Adams GN, Sharma BK, Rosenfeldt L, Frederick M, Flick MJ, Witte DP, Mosnier LO, Harmel-Laws E, Steinbrecher KA, Palumbo JS. Protease activated receptor-1 impedes prostate and intestinal tumor progression in mice. Journal of Thrombosis and Haemostasis : Jth. PMID 30152921 DOI: 10.1111/Jth.14277 |
0.376 |
|
| 2018 |
Flick MJ, Palumbo JS. Platelets couple inflammation to tumorigenesis, a bridge too far. Journal of Thrombosis and Haemostasis : Jth. PMID 29418061 DOI: 10.1111/Jth.13967 |
0.389 |
|
| 2018 |
Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, ... ... Flick MJ, et al. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. Proceedings of the National Academy of Sciences of the United States of America. PMID 29386381 DOI: 10.1073/Pnas.1720553115 |
0.335 |
|
| 2018 |
Kattula S, Byrnes JR, Martin SM, Holle LA, Cooley BC, Flick MJ, Wolberg AS. Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice. Blood Advances. 2: 25-35. PMID 29344582 DOI: 10.1182/Bloodadvances.2017011890 |
0.372 |
|
| 2018 |
Negron O, Koopman J, Weggeman M, Huisman L, Stang A, Flick MJ. A Human Fibrinogen Variant with Impaired Staphylococcus Aureus Binding Function Promotes Host Survival during Septicemia in Mice Blood. 132: 3775-3775. DOI: 10.1182/Blood-2018-99-118491 |
0.396 |
|
| 2018 |
Boucher AA, Rosenfeldt LA, Mureb D, Kopec AK, Luyendyk JP, Flick MJ, Palumbo JS. Inflammation and Tissue Damage Mediated By PAR-1 Expression Is Cell Type-Specific and Varies Depending on the Inflammatory Challenge Blood. 132: 133-133. DOI: 10.1182/Blood-2018-99-117312 |
0.452 |
|
| 2018 |
Mullins ES, Shaw MA, Gao Z, Flick MJ. Plasmin-Mediated Fibrinolysis Enables Macrophage Migration Via Liberation from Fibrin-αMβ2 Interactions Blood. 132: 136-136. DOI: 10.1182/Blood-2018-99-117018 |
0.454 |
|
| 2018 |
Nasimuzzaman M, Arumugam PI, Mullins ES, James JM, VandenHeuvel K, Narciso M, Shaw MA, McGraw S, Aronow BJ, Flick MJ, Malik P. Diminished Renal Pathology in a Mouse Model of Sickle Cell Anemia in Which Fibrinogen Binding to Mac-1 Is Inhibited Blood. 132: 267-267. DOI: 10.1182/Blood-2018-99-112641 |
0.485 |
|
| 2017 |
Thornton S, Raghu H, Cruz C, Frederick MD, Palumbo JS, Mullins ES, Almholt K, Usher PA, Flick MJ. Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells. Blood Advances. 1: 545-556. PMID 29296974 DOI: 10.1182/Bloodadvances.2016004002 |
0.493 |
|
| 2017 |
Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ. Thrombin promotes diet-induced obesity through fibrin-driven inflammation. The Journal of Clinical Investigation. PMID 28737512 DOI: 10.1172/Jci92744 |
0.367 |
|
| 2017 |
Shaw MA, Gao Z, McElhinney KE, Thornton S, Flick MJ, Lane A, Degen JL, Kyu Ryu J, Akassoglou K, Mullins ES. Plasminogen deficiency delays the onset and protects from demyelination and paralysis in autoimmune neuroinflammatory disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28275164 DOI: 10.1523/Jneurosci.2932-15.2017 |
0.633 |
|
| 2017 |
Gao Z, Shaw MA, Palumbo JS, Flick MJ, Mullins ES. Mice Lacking Factor XIII Have Significant Protection from the Progression of Neuroinflammatory Disease Blood. 130: 237-237. DOI: 10.1182/Blood.V130.Suppl_1.237.237 |
0.437 |
|
| 2016 |
Kopec AK, Joshi N, Cline-Fedewa H, Wojcicki AV, Ray JL, Sullivan BP, Froehlich JE, Johnson BF, Flick MJ, Luyendyk JP. Fibri(nogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of MMP12. Journal of Hepatology. PMID 27965156 DOI: 10.1016/J.Jhep.2016.12.004 |
0.425 |
|
| 2016 |
Flick MJ, Bugge TH. Plasminogen-receptor KT : Plasminogen activation and beyond. Journal of Thrombosis and Haemostasis : Jth. PMID 27740735 DOI: 10.1111/Jth.13541 |
0.376 |
|
| 2016 |
Mignemi NA, Yuasa M, Baker CE, Moore SN, Ihejirika RC, Oelsner WK, Wallace CS, Yoshii T, Okawa A, Revenko AS, MacLeod AF, Bhattacharjee G, Barnett JV, Schwartz HS, Degen JL, ... Flick MJ, et al. Plasmin Prevents Dystrophic Calcification after Muscle Injury. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 27530373 DOI: 10.1002/Jbmr.2973 |
0.546 |
|
| 2016 |
Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES. Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Blood. PMID 27252233 DOI: 10.1182/Blood-2015-11-680280 |
0.676 |
|
| 2016 |
Ko YP, Flick MJ. Fibrinogen Is at the Interface of Host Defense and Pathogen Virulence in Staphylococcus aureus Infection. Seminars in Thrombosis and Hemostasis. PMID 27056151 DOI: 10.1055/S-0036-1579635 |
0.309 |
|
| 2016 |
Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP. Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism. Blood. PMID 26921287 DOI: 10.1182/Blood-2015-09-670703 |
0.432 |
|
| 2015 |
Motley MP, Madsen DH, Jürgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH. A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood. PMID 26647393 DOI: 10.1182/Blood-2015-05-644260 |
0.389 |
|
| 2015 |
Yuasa M, Mignemi NA, Nyman JS, Duvall CL, Schwartz HS, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible JE, Obremskey WT, Flick MJ, Degen JL, Barnett JV, Cates JM, et al. Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. The Journal of Clinical Investigation. 125: 3723. PMID 26325037 DOI: 10.1172/JCI84059 |
0.438 |
|
| 2015 |
Adams GN, Rosenfeldt L, Frederick M, Miller W, Waltz D, Kombrinck K, McElhinney KE, Flick MJ, Monia BP, Revenko AS, Palumbo JS. Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen. Cancer Research. PMID 26238780 DOI: 10.1158/0008-5472.Can-15-0964 |
0.444 |
|
| 2015 |
Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. PMID 26228483 DOI: 10.1182/Blood-2015-04-639849 |
0.676 |
|
| 2015 |
Yuasa M, Mignemi NA, Nyman JS, Duvall CL, Schwartz HS, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible JE, Obremskey WT, Flick MJ, Degen JL, Barnett JV, Cates JM, et al. Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. The Journal of Clinical Investigation. PMID 26214526 DOI: 10.1172/Jci80313 |
0.547 |
|
| 2015 |
Joshi N, Kopec AK, O'Brien KM, Towery KL, Cline-Fedewa H, Williams KJ, Copple BL, Flick MJ, Luyendyk JP. Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice. Journal of Thrombosis and Haemostasis : Jth. 13: 57-71. PMID 25353084 DOI: 10.1111/Jth.12770 |
0.32 |
|
| 2015 |
Raghu H, Cruz C, Rewerts CL, Frederick MD, Thornton S, Mullins ES, Schoenecker JG, Degen JL, Flick MJ. Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. Blood. 125: 427-37. PMID 25336631 DOI: 10.1182/Blood-2014-08-594754 |
0.652 |
|
| 2015 |
Flick MJ, Rewerts C, Cruz C, Palumbo JS, Luyendyk JP, Yang Y, Konieczny SF. Tumor Cell Thrombin/PAR-1 Signaling Drives Pancreatic Ductal Adenocarcinoma Growth and Dissemination Blood. 126: 1070-1070. DOI: 10.1182/Blood.V126.23.1070.1070 |
0.768 |
|
| 2014 |
Kopec AK, Joshi N, Towery KL, Kassel KM, Sullivan BP, Flick MJ, Luyendyk JP. Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice. The Journal of Pharmacology and Experimental Therapeutics. 351: 288-97. PMID 25138021 DOI: 10.1124/Jpet.114.218545 |
0.371 |
|
| 2014 |
Aleman MM, Byrnes JR, Wang JG, Tran R, Lam WA, Paola JD, Mackman N, Degen JL, Flick MJ, Wolberg AS. Factor XIII activity mediates red blood cell retention in venous thrombi Journal of Clinical Investigation. 124: 3590-3600. PMID 24983320 DOI: 10.1172/Jci75386 |
0.667 |
|
| 2014 |
Turpin B, Miller W, Rosenfeldt L, Kombrinck K, Flick MJ, Steinbrecher KA, Harmel-Laws E, Mullins ES, Shaw M, Witte DP, Revenko A, Monia B, Palumbo JS. Thrombin drives tumorigenesis in colitis-associated colon cancer Cancer Research. 74: 3020-3030. PMID 24710407 DOI: 10.1158/0008-5472.Can-13-3276 |
0.448 |
|
| 2014 |
Cole HA, Ohba T, Nyman JS, Hirotaka H, Cates JMM, Flick MJ, Degen JL, Schoenecker JG. Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice Arthritis and Rheumatology. 66: 2222-2233. PMID 24664548 DOI: 10.1002/Art.38639 |
0.625 |
|
| 2014 |
Raghu H, Jone A, Cruz C, Rewerts CL, Frederick MD, Thornton S, Degen JL, Flick MJ. Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice. Arthritis & Rheumatology (Hoboken, N.J.). 66: 1504-16. PMID 24574269 DOI: 10.1002/Art.38402 |
0.621 |
|
| 2014 |
Thornton S, Raghu H, Jone A, Cruz C, Rewerts CL, Frederick MD, Degen JL, Flick MJ. Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis Blood. 124: 580-580. DOI: 10.1182/Blood.V124.21.580.580 |
0.665 |
|
| 2013 |
Flick MJ, Du X, Prasad JM, Raghu H, Palumbo JS, Smeds E, Ḧöok M, Degen JL. Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia Blood. 121: 1783-1794. PMID 23299312 DOI: 10.1182/Blood-2012-09-453894 |
0.636 |
|
| 2013 |
Aleman MM, Byrnes JR, Wang J, Mackman N, Degen JL, Flick MJ, Wolberg AS. Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi, Blood. 122: 451-451. DOI: 10.1182/Blood.V122.21.451.451 |
0.588 |
|
| 2012 |
Sullivan BP, Kassel KM, Jone A, Flick MJ, Luyendyk JP. Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury. The American Journal of Pathology. 180: 2321-9. PMID 22507835 DOI: 10.1016/J.Ajpath.2012.02.011 |
0.346 |
|
| 2012 |
Qi X, Flick MJ, Frederick M, Chu Z, Mason R, DeLay M, Thornton S. Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity Plos One. 7. PMID 22470501 DOI: 10.1371/Journal.Pone.0033966 |
0.319 |
|
| 2012 |
Vidal B, Ardite E, Suelves M, Ruiz-Bonilla V, Janué A, Flick MJ, Degen JL, Serrano AL, Muñoz-Cánoves P. Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the α mβ 2 leukocyte integrin receptor Human Molecular Genetics. 21: 1989-2004. PMID 22381526 DOI: 10.1093/Hmg/Dds012 |
0.637 |
|
| 2012 |
Mullins ES, Shaw MA, McElhinney KE, Kombrinck KW, Flick MJ, Brill A, Wagner DD, Degen JL. Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation Blood. 120: 496-496. DOI: 10.1182/Blood.V120.21.496.496 |
0.688 |
|
| 2012 |
Turpin BK, Steinbrecher K, Shaw M, McElhinney KE, Baylis R, Flick MJ, Miller WM, Palumbo JS. PAR-1 Is a Context Dependent Determinant of Colitis and Colitis-Associated Cancer. Blood. 120: 2221-2221. DOI: 10.1182/Blood.V120.21.2221.2221 |
0.48 |
|
| 2011 |
Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood. 118: 2889-95. PMID 21788337 DOI: 10.1182/Blood-2011-03-341222 |
0.65 |
|
| 2011 |
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, et al. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 117: 6326-37. PMID 21436072 DOI: 10.1182/Blood-2010-08-304915 |
0.683 |
|
| 2011 |
Raghu H, Flick MJ. Targeting the coagulation factor fibrinogen for arthritis therapy Current Pharmaceutical Biotechnology. 12: 1497-1506. PMID 21401516 DOI: 10.2174/138920111798281144 |
0.372 |
|
| 2011 |
Raghu H, Frederick MD, Jone A, Talmage KE, Kombrinck KW, Flick MJ. Plasminogen Mediates Both Positive and Negative Effects on Disease Severity in a Mouse Model of TNFα-Driven Arthritis Blood. 118: 854-854. DOI: 10.1182/Blood.V118.21.854.854 |
0.459 |
|
| 2011 |
Turpin BK, Miller WM, Mullins ES, Degen JL, Flick MJ, Monia BP, MacLeod R, Revenko AS, Palumbo JS. Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis Blood. 118: 2237-2237. DOI: 10.1182/Blood.V118.21.2237.2237 |
0.661 |
|
| 2010 |
Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS. Colitis-associated cancer Is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin αMβ2 engagement of fibrinogen Cancer Research. 70: 2634-2643. PMID 20233870 DOI: 10.1158/0008-5472.Can-09-3465 |
0.469 |
|
| 2010 |
Lykens JE, Terrell CE, Zoller EE, Divanovic S, Trompette A, Karp CL, Aliberti J, Flick MJ, Jordan MB. Mice with a selective impairment of IFN-γ signaling in macrophage lineage cells demonstrate the critical role of IFN-γ-activated macrophages for the control of protozoan parasitic infections in vivo Journal of Immunology. 184: 877-885. PMID 20018611 DOI: 10.4049/Jimmunol.0902346 |
0.405 |
|
| 2010 |
Flick MJ, Du X, Fausnacht L, Raghu H, Talmage KE, Kombrinck KW, Blevins EA, Mullins ES, Palumbo JS, Degen JL. Host Prothrombin and Fibrinogen Support S. Aureus Virulence In the Context of Acute Bacteremia Blood. 116: 821-821. DOI: 10.1182/Blood.V116.21.821.821 |
0.643 |
|
| 2010 |
Prasad JM, Du X, Mullins ES, Divanovic S, Talmage KE, Kombrinck KW, Cheng AG, Schneewind O, Flick MJ, Degen JL. Host Fibrinogen and the S. Aureus-Encoded Procoagulant Vwbp Are Context-Dependent Determinants of Bacterial Virulence. Blood. 116: 1152-1152. DOI: 10.1182/Blood.V116.21.1152.1152 |
0.634 |
|
| 2009 |
Yang H, Lang S, Zhai Z, Li L, Kahr WHA, Chen P, Brkić J, Spring CM, Flick MJ, Degen JL, Freedman J, Ni H. Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression Blood. 114: 425-436. PMID 19332769 DOI: 10.1182/Blood-2008-03-145821 |
0.564 |
|
| 2009 |
Lian L, Wang Y, Flick M, Choi J, Scott EW, Degen J, Lemmon MA, Abrams CS. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood. 113: 3577-84. PMID 19190246 DOI: 10.1182/Blood-2008-09-178913 |
0.598 |
|
| 2009 |
Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood. 113: 696-704. PMID 18927430 DOI: 10.1182/Blood-2008-07-169003 |
0.657 |
|
| 2009 |
Horowitz N, Steinbrecher KA, Shaw MA, Barney KA, Flick M, Harmel-Laws E, Witte D, Blevins EA, Palumbo JS. Fibrinogen Supports Colitis-Associated Adenoma Progression through a Mechanism Coupled to Engagement of the Leukocyte Integrin αMβ2. Blood. 114: 334-334. DOI: 10.1182/blood.v114.22.334.334 |
0.388 |
|
| 2009 |
Mullins ES, Talmage KE, Flick M, Kombrinck KW, Strait RT, Degen JL. Transfusion Related Acute Lung Injury (TRALI) Is Ameliorated by Genetic Elimination of Fibrin(ogen) in Mice. Blood. 114: 3189-3189. DOI: 10.1182/Blood.V114.22.3189.3189 |
0.611 |
|
| 2009 |
Flick MJ, Du X, Talmage KE, Kombrink KW, Blevins EA, Palumbo JS, Degen JL. The Virulence of S. Aureus Is Supported by Host Fibrinogen and Its Bacterial Receptor ClfA in the Context of Bacteremia. Blood. 114: 3188-3188. DOI: 10.1182/Blood.V114.22.3188.3188 |
0.65 |
|
| 2009 |
Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain Blood. 113: 696-704. DOI: 10.1182/blood-2008-07-169003 |
0.532 |
|
| 2008 |
Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function Journal of Thrombosis and Haemostasis. 6: 812-819. PMID 18315549 DOI: 10.1111/J.1538-7836.2008.02938.X |
0.617 |
|
| 2008 |
Steinbrecher KA, Horowitz N, Shaw MA, Barney KA, Flick MJ, Harmel-Laws E, Witte DP, Blevins EA, Palumbo JS. Hemostatic Factors Support Colitis and Colitis-Associated Colon Cancer Blood. 112: 3079-3079. DOI: 10.1182/Blood.V112.11.3079.3079 |
0.507 |
|
| 2007 |
Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin αMβ2 binding motif Journal of Clinical Investigation. 117: 3224-3235. PMID 17932565 DOI: 10.1172/Jci30134 |
0.647 |
|
| 2007 |
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and -independent mechanisms Blood. 110: 133-141. PMID 17371949 DOI: 10.1182/Blood-2007-01-065995 |
0.641 |
|
| 2007 |
Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease Journal of Experimental Medicine. 204: 571-582. PMID 17339406 DOI: 10.1084/Jem.20061931 |
0.613 |
|
| 2007 |
Mullins ES, Kombrinck KW, Flick MJ, Shaw MA, Sun W, Degen SJ, Akassoglou K, Degen JL. Reduction of Prothrombin in Mice Carrying a Conditional Knockout Allele Attenuates the Development of Paralysis Associated with Experimental Encephalitis. Blood. 110: 407-407. DOI: 10.1182/Blood.V110.11.407.407 |
0.659 |
|
| 2007 |
Flick MJ, Chauhan AK, Welch S, Shaw MA, Talmage KE, Mullins ES, Palumbo JS, Thornton S, Wagner DD, Degen JL. Mice Engineered To Express a Form of Thrombin Favoring Protein C Are Resistant to S. aureus-Induced Sepsis. Blood. 110: 267-267. DOI: 10.1182/Blood.V110.11.267.267 |
0.681 |
|
| 2007 |
Palumbo JS, Barney KA, Williams EA, Shaw MA, Mishra A, Flick MJ, Talmage KE, Degen JL. Factor XIII Supports Metastatic Potential through a Mechanism Coupled to Natural Killer Cell Function. Blood. 110: 1753-1753. DOI: 10.1182/Blood.V110.11.1753.1753 |
0.663 |
|
| 2007 |
Wang Y, Lian L, Flick M, Degen J, Lemmon M, Abrams CS. Mice Lacking Pleckstrin or Pleckstrin-2 Each Have Unique Platelet Secretion Defects. Blood. 110: 134-134. DOI: 10.1182/Blood.V110.11.134.134 |
0.597 |
|
| 2006 |
Palumbo J, Barney KA, Flick MJ, Talmage KE, Kombrinck KW, Hu Z, La Jeunesse CM, Degen JL. Tumor Cell-Associated Tissue Factor Supports Metastatic Potential through Both NK Cell-Dependent and -Independent Mechanisms. Blood. 108: 66-66. DOI: 10.1182/Blood.V108.11.66.66 |
0.634 |
|
| 2006 |
Flick MJ, La Jeunesse CM, Talmage KE, Witte DP, Palumbo J, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) Exacerbates Inflammatory Joint Disease Via a Mechanism Linked to Its αMβ2 Binading Motif. Blood. 108: 64-64. DOI: 10.1182/Blood.V108.11.64.64 |
0.654 |
|
| 2006 |
Lian L, Wang Y, Chen X, Bach T, Lenox L, Zhu P, Flick M, Scott E, Degen J, Freedman B, Koretzky G, Lemmon M, Abrams CS. Knockout of the PKC Substrate Pleckstrin Causes Pleomorphic Defects in Platelets, Lymphocytes and Granulocytes. Blood. 108: 394-394. DOI: 10.1182/Blood.V108.11.394.394 |
0.613 |
|
| 2006 |
Mullins ES, Flick MJ, Kombrinck KW, Degen SJ, Sun W, Degen JL. Conditional Disruption of the Murine Prothrombin Gene. Blood. 108: 1600-1600. DOI: 10.1182/Blood.V108.11.1600.1600 |
0.688 |
|
| 2006 |
Flick M, Welch S, La Jeunesse C, Talmage K, Mullins E, Palumbo J, Thornton S, Degen J. ID: 097 Mice expressing a thrombin variant engineered to favor anticoagulant function are resistant to S. aureus-induced sepsis Journal of Thrombosis and Haemostasis. 4: 115-115. DOI: 10.1111/J.1538-7836.2006.00097.X |
0.562 |
|
| 2006 |
Adams R, Bauer J, Sikorski S, Nuriel T, Flick M, Lassmann H, Degen J, Akassoglou K. ID: 071 Fibrin/Mac-1 interactions induce microglia activation and regulate relapsing paralysis in central nervous system autoimmune disease Journal of Thrombosis and Haemostasis. 4: 133-133. DOI: 10.1111/J.1538-7836.2006.00071.X |
0.555 |
|
| 2005 |
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jirousková M, Degen JL. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells Blood. 105: 178-185. PMID 15367435 DOI: 10.1182/Blood-2004-06-2272 |
0.649 |
|
| 2005 |
Palumbo JS, Massari JV, La Jeunesse CM, Flick MJ, Hu Z, Talmage KE, Degen JL. Interplay between Tumor Cell-Associated and Circulating Coagulation Factors in Establishing Metastatic Potential. Blood. 106: 686-686. DOI: 10.1182/Blood.V106.11.686.686 |
0.635 |
|
| 2005 |
Flick MJ, Du X, Talmage KE, LaJeunesse CM, Witte DP, Palumbo JS, Degen JL. Hemostatic Factors Regulate Immune Surveillance and Contribute to the Rapid Clearance of Bacterial Pathogens In Vivo. Blood. 106: 2132-2132. DOI: 10.1182/Blood.V106.11.2132.2132 |
0.679 |
|
| 2004 |
Flick MJ, Du X, Degen JL. Fibrin(ogen)-αMβ2 interactions regulate leukocyte function and innate immunity in vivo Experimental Biology and Medicine. 229: 1105-1110. PMID 15564436 DOI: 10.1177/153537020422901104 |
0.604 |
|
| 2004 |
Flick MJ, Du X, Witte DP, Jiroušková M, Soloviev DA, Busuttil SJ, Plow EF, Degen JL. Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo Journal of Clinical Investigation. 113: 1596-1606. PMID 15173886 DOI: 10.1172/Jci20741 |
0.536 |
|
| 2004 |
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Jirouskova M, Degen JL. Hemostatic Factors Contribute to Tumor Cell Metastatic Potential by a Mechanism Linked to Natural Killer Cell Function. Blood. 104: 690-690. DOI: 10.1182/Blood.V104.11.690.690 |
0.667 |
|
| 2002 |
Flick MJ, Konieczny SF. Identification of putative mammalian D-lactate dehydrogenase enzymes. Biochemical and Biophysical Research Communications. 295: 910-6. PMID 12127981 DOI: 10.1016/S0006-291X(02)00768-4 |
0.674 |
|
| 2000 |
Flick MJ, Konieczny SF. The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of betaI-spectrin. Journal of Cell Science. 113: 1553-64. PMID 10751147 |
0.672 |
|
| 1998 |
Bugge TH, Lund LR, Kombrinck KK, Nielsen BS, Holmbäck K, Drew AF, Flick MJ, Witte DP, Danø K, Degen JL. Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice Oncogene. 16: 3097-3104. PMID 9671388 DOI: 10.1038/Sj.Onc.1201869 |
0.611 |
|
| 1997 |
Kong Y, Flick MJ, Kudla AJ, Konieczny SF. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Molecular and Cellular Biology. 17: 4750-60. PMID 9234731 DOI: 10.1128/Mcb.17.8.4750 |
0.682 |
|
| 1997 |
Bugge TH, Lund LR, Kombrinck KK, Nielsen BS, Holmbäck K, Drew AF, Flick MJ, Witte DP, Danø K, Degen JL. 82 Reduced breast cancer metastasis in plasminogen-deficient mice Fibrinolysis and Proteolysis. 11: 24. DOI: 10.1016/S0268-9499(97)80198-1 |
0.593 |
|
| 1997 |
Bugge TH, Danton MJS, Dang K, Daugherty CC, Drew A, Flick MJ, Holmbäck K, Kaol W, Kombrinck KW, Lund LR, Pyke C, Romcr J, Strickland S, Tsirka SE, Xiaoli Q, et al. Biological roles and substrates of plasmin in the mouse Faseb Journal. 11: A1444. |
0.507 |
|
| 1996 |
Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJS, Degen JL. Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency Cell. 87: 709-719. PMID 8929539 DOI: 10.1016/S0092-8674(00)81390-2 |
0.637 |
|
| 1996 |
Bugge TH, Xiao Q, Kombrinck KW, Flick MJ, Holmback K, Danton MJS, Colbert MC, Witte DP, Fujikawa K, Davie EW, Degen JL. Fatal embryonic bleeding events in mice lacking tissue factor, the cell- associated initiator of blood coagulation Proceedings of the National Academy of Sciences of the United States of America. 93: 6258-6263. PMID 8692802 DOI: 10.1073/Pnas.93.13.6258 |
0.65 |
|
| 1996 |
Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Dano K, Thompson WD, Stirk CM, Melvin WT, Smith EB. Plasminogen and wound healing [5] Nature Medicine. 2: 725. PMID 8673908 DOI: 10.1038/Nm0796-725A |
0.458 |
|
| 1996 |
Bugge TH, Flick MJ, Danton MJ, Daugherty CC, Romer J, Dano K, Carmeliet P, Collen D, Degen JL. Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America. 93: 5899-904. PMID 8650190 DOI: 10.1073/Pnas.93.12.5899 |
0.671 |
|
| 1996 |
Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Dano K. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Medicine. 2: 287-92. PMID 8612226 DOI: 10.1038/Nm0396-287 |
0.577 |
|
| 1996 |
Bugge TH, Flick MJ, Danton MJS, Daugherty CC, Rømer J, Danø K, Carmeliet P, Collen D, Degen JL. Urokinase-Type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-Type plasminogen activator Fibrinolysis. 10: 79. DOI: 10.1073/pnas.93.12.5899 |
0.503 |
|
| 1996 |
Bugge TH, Kombrinck K, Flick MJ, Daugherty CC, Mjs D, Degen JL. Complete rescue of the pleiotropic effects of plasminogen-deficiency by fibrinogen-deficiency Fibrinolysis. 10: 19. |
0.532 |
|
| 1996 |
Degen JL, Xiao Q, Kombrinck K, Flick MJ, Holmbäck K, Mjs D, Colbert MC, Witte DP, Fujikawa K, Davie EW, Bugge TH. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation Fibrinolysis. 10: 19. |
0.596 |
|
| 1996 |
Bugge TH, Lund LR, Kombrinck KW, Flick MJ, Degen JL. Metastatic mammary tumors in plasminogen-deficient mice Fibrinolysis. 10: 79. |
0.619 |
|
| 1996 |
Rømer J, Bugge T, Pyke C, Lund LR, Flick MJ, Degen JL, Danø K. Impaired wound healing in mice with a disrupted plasminogen gene Fibrinolysis. 10: 78. |
0.572 |
|
| 1996 |
Rømer J, Bugge T, Pyke C, Lund LR, Flick MJ, Degen JL, Danø K. Impaired wound healing in mice with a disrupted plasminogen gene Fibrinolysis. 10: 78. |
0.572 |
|
| 1995 |
Bugge TH, Flick MJ, Daugherty CC, Degen JL. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction Genes and Development. 9: 794-807. PMID 7705657 DOI: 10.1101/Gad.9.7.794 |
0.667 |
|
| 1995 |
Bugge TH, Suh TT, Flick MJ, Daugherty CC, Romer J, Solberg H, Ellis V, Dano K, Degen JL. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility Journal of Biological Chemistry. 270: 16886-16894. PMID 7622505 DOI: 10.1074/Jbc.270.28.16886 |
0.689 |
|
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