Stephan R. Targan - Publications

Affiliations: 
Cedars-Sinai Medical Center, Los Angeles, CA, United States 

310 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Parrish AB, Lopez NE, Truong A, Zaghiyan K, Melmed GY, McGovern DPB, Ha C, Syal G, Bonthala N, Jain A, Landers CJ, Targan SR, Fleshner P. Preoperative Serum Vedolizumab Levels Do Not Impact Postoperative Outcomes in Inflammatory Bowel Disease. Diseases of the Colon and Rectum. 64: 1259-1266. PMID 34516445 DOI: 10.1097/DCR.0000000000001920  1
2021 Wenxiu J, Mingyue Y, Fei H, Yuxin L, Mengyao W, Chenyang L, Jia S, Hong Z, Shih DQ, Targan SR, Xiaolan Z. Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis. Mediators of Inflammation. 2021: 5927064. PMID 34257516 DOI: 10.1155/2021/5927064  1
2021 Truong A, Zaghiyan KN, Mirocha J, Melmed GY, McGovern DP, Syal G, Ha CY, Targan SR, Fleshner PR. Anti-Tumour Necrosis Factor Therapy is Associated with Denovo Crohn's Disease After Ileal Pouch-Anal Anastomosis. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland. PMID 34157179 DOI: 10.1111/codi.15772  1
2021 Sandborn WJ, Rebuck R, Wang Y, Zou B, Adedokun OJ, Gasink C, Sands BE, Hanauer SB, Targan S, Ghosh S, de Villiers WJ, Colombel JF, Feagan BG, Lynch JP. Five-year Efficacy and Safety of Ustekinumab Treatment in Crohn's Disease: the IM-UNITI trial. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. PMID 33618023 DOI: 10.1016/j.cgh.2021.02.025  1
2020 Workman MJ, Troisi E, Targan SR, Svendsen CN, Barrett RJ. Modeling Intestinal Epithelial Response to Interferon-γ in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids. International Journal of Molecular Sciences. 22. PMID 33396621 DOI: 10.3390/ijms22010288  1
2020 Syal G, Shemtov R, Bonthala N, Vasiliauskas EA, Feldman EJ, Zaghiyan K, Ha CY, McGovern DPB, Targan SR, Melmed GY, Fleshner PR. Pre-Pouch Ileitis is Associated with Development of Crohn's Disease-Like Complications and Pouch Failure. Journal of Crohn's & Colitis. PMID 33300546 DOI: 10.1093/ecco-jcc/jjaa251  1
2020 Potdar AA, Dube S, Naito T, Li K, Botwin G, Haritunians T, Li D, Casero D, Yang S, Bilsborough J, Perrigoue JG, Denson LA, Daly M, Targan SR, Fleshner P, et al. Altered intestinal ACE2 levels are associated with inflammation, severe disease and response to anti-cytokine therapy in IBD. Gastroenterology. PMID 33160965 DOI: 10.1053/j.gastro.2020.10.041  1
2020 Halloran BP, Jamil LH, Lo SK, Reeson M, Vasiliauskas EA, Targan S, Ippoliti A, Mann NK, Melmed GY. Double-Balloon Endoscopy in Crohn Disease: A Tertiary Referral Center Experience. Inflammatory Bowel Diseases. PMID 33155643 DOI: 10.1093/ibd/izaa287  1
2020 Jacob N, Kumagai K, Abraham JP, Shimodaira Y, Ye Y, Luu J, Blackwood AY, Castanon SL, Stamps DT, Thomas LS, Gonsky R, Shih DQ, Michelsen KS, Targan SR. Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo. Scientific Reports. 10: 18189. PMID 33097818 DOI: 10.1038/s41598-020-75168-5  1
2020 Panaccione R, Danese S, Sandborn WJ, O'Brien CD, Zhou Y, Zhang H, Adedokun OJ, Tikhonov I, Targan S, Abreu MT, Hisamatsu T, Scherl EJ, Leong RW, Rowbotham DS, Arasaradnam RP, et al. Ustekinumab is effective and safe for ulcerative colitis through 2 years of maintenance therapy. Alimentary Pharmacology & Therapeutics. PMID 33086438 DOI: 10.1111/apt.16119  1
2020 Han F, Song J, Jia W, Yang M, Wang D, Zhang H, Shih DQ, Targan SR, Zhang X. TL1A primed dendritic cells activation exacerbated chronic murine colitis. Life Sciences. 118220. PMID 32781075 DOI: 10.1016/j.lfs.2020.118220  1
2020 Potdar AA, Dube S, Naito T, Botwin G, Haritunians T, Li D, Yang S, Bilsborough J, Denson LA, Daly M, Targan SR, Fleshner P, Braun J, Kugathasan S, Stappenbeck TS, et al. Reduced expression of COVID-19 host receptor, is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn's disease. Medrxiv : the Preprint Server For Health Sciences. PMID 32511625 DOI: 10.1101/2020.04.19.20070995  1
2020 Syal G, Robbins L, Kashani A, Bonthala N, Feldman E, Fleshner P, Vasiliauskas E, McGovern D, Ha C, Targan S, Melmed GY. Hypoalbuminemia and Bandemia Predict Failure of Infliximab Rescue Therapy in Acute Severe Ulcerative Colitis. Digestive Diseases and Sciences. PMID 32170473 DOI: 10.1007/S10620-020-06177-7  1
2020 Gleeson JP, Estrada HQ, Yamashita M, Svendsen CN, Targan SR, Barrett RJ. Development of Physiologically Responsive Human iPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD. International Journal of Molecular Sciences. 21. PMID 32093254 DOI: 10.3390/Ijms21041438  1
2020 Du L, Li D, Syal G, Bonthala N, Melmed G, Targan SR, Vasiliauskas E, Ziring D, Haritunians T, Botwin GJ, Hwang L, Yang S, Rabizadeh S, Ha C, McGovern DPB. Mo1859 CLINICAL, SEROLOGIC, AND GENOMIC PREDICTORS OF RESPONSE TO USTEKINUMAB IN CROHN'S DISEASE Gastroenterology. 158. DOI: 10.1016/S0016-5085(20)33059-6  1
2020 Li D, Botwin GJ, Haritunians T, Targan SR, McGovern DPB. Mo1110 INTEGRATING EQTL EVIDENCE AND GWAS SUMMARY STATISTICS TO REFINE KNOWN SIGNALS AND IDENTIFY NOVEL CD GENES USING MENDELIAN RANDOMIZATION Gastroenterology. 158. DOI: 10.1016/S0016-5085(20)32651-2  1
2020 Dube S, Haritunians T, Li D, Hwang L, Yang S, Targan SR, Kallman C, McGovern DPB. Su1979 NOVEL ASSOCIATIONS OF ADIPOSE TISSUE (AT) VOLUMETRIC MEASURES WITH CLINICAL, SEROLOGIC, AND GENETIC VARIABLES IN CROHN'S DISEASE (CD) AND ULCERATIVE COLITIS (UC) Gastroenterology. 158. DOI: 10.1016/S0016-5085(20)32505-1  1
2020 Potdar AA, Li D, Haritunians T, Targan SR, McGovern DPB, Bilsborough J. Su1877 ENRICHMENT OF POST-TRANSLATIONAL MODIFICATIONS IN INFLAMMATORY BOWEL DISEASE Gastroenterology. 158. DOI: 10.1016/S0016-5085(20)32404-5  1
2020 Dube S, Li D, Haritunians T, Hwang L, Yang S, Targan SR, Kallman C, McGovern DPB. 717 Novel Associations Of Brain Morphometry With Clinical, Serologic, And Genetic Variables In Crohn'S Disease (Cd) And Ulcerative Colitis (Uc) Gastroenterology. 158. DOI: 10.1016/S0016-5085(20)31063-5  1
2020 Ye Y, Shimodaira Y, Blackwood AY, Hamade H, Castanon S, Jacob N, Jacobs JP, Potdar AA, McGovern DPB, Targan SR, Michelsen KS. 567 Tl1A Overexpression In Cd Patients And Mice Alters Paneth Cell Biology And Intestinal Microbiota In Promoting Ileal Inflammation Gastroenterology. 158. DOI: 10.1016/S0016-5085(20)30973-2  1
2019 Sands BE, Sandborn WJ, Panaccione R, O'Brien CD, Zhang H, Johanns J, Adedokun OJ, Li K, Peyrin-Biroulet L, Van Assche G, Danese S, Targan S, Abreu MT, Hisamatsu T, Szapary P, et al. Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis. The New England Journal of Medicine. 381: 1201-1214. PMID 31553833 DOI: 10.1056/NEJMoa1900750  1
2019 Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, ... ... Targan S, et al. Correction: Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. Plos Genetics. 15: e1008190. PMID 31145742 DOI: 10.1371/journal.pgen.1008190  1
2019 Potdar AA, Li D, Haritunians T, VanDussen KL, Fiorino MF, Liu TC, Stappenbeck TS, Fleshner P, Targan SR, McGovern DPB, Bilsborough J. Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Sub-Groups. Journal of Crohn's & Colitis. PMID 30877309 DOI: 10.1093/Ecco-Jcc/Jjz021  1
2019 Limon JJ, Tang J, Li D, Wolf AJ, Michelsen KS, Funari V, Gargus M, Nguyen C, Sharma P, Maymi VI, Iliev ID, Skalski JH, Brown J, Landers C, Borneman J, ... ... Targan SR, et al. Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models. Cell Host & Microbe. PMID 30850233 DOI: 10.1016/J.Chom.2019.01.007  1
2019 Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, ... ... Targan SR, et al. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science (New York, N.Y.). 363: 993-998. PMID 30819965 DOI: 10.1126/Science.Aat7186  1
2019 Tsuda M, Hamade H, Thomas LS, Salumbides BC, Potdar AA, Wong MH, Nunnelee JS, Stamps JT, Neutzsky-Wulff AV, Barrett RJ, Wang Y, Tang J, Funari VA, Targan SR, Michelsen KS. A role for BATF3 in T9 differentiation and T-cell-driven mucosal pathologies. Mucosal Immunology. PMID 30617301 DOI: 10.1038/S41385-018-0122-4  1
2019 Sands B, Peyrin-Biroulet L, Marano C, O'Brien C, Zhang H, Johanns J, Szapary P, Rowbotham D, Leong R, Arasaradnam R, Danese S, Assche Gv, Targan S, Sandborn W. Efficacy in Biologic Failure and Nonbiologic-Failure Populations in a Phase 3 Study of Ustekinumab in Moderate-Severe Ulcerative Colitis: UNIFI Zeitschrift Fur Gastroenterologie. 57: 9. DOI: 10.1055/S-0039-1691869  1
2019 Dube S, Li D, Haritunians T, Yang S, Targan SR, McGovern D. Tu1761 – Polygenic Risk Scores are Associated with Serological Markers Highlighting Disease Heterogeneity in Crohn's Disease (CD) and Ulcerative Colitis (UC) Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)39747-1  1
2019 Dube S, Li D, Haritunians T, Yang S, Botwin GJ, Targan SR, McGovern D. Su1923 – Novel Associations of Platelets with Clinical and Serologic Variables in Crohn’s Disease (CD) and Ulcerative Colitis (UC) Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)38560-9  1
2019 Potdar AA, Haritunians T, Fiorino MF, Botwin GJ, Li D, Targan SR, McGovern D, Bilsborough J. Su1906 – Markers for Severe, Refractory Crohn’s Disease Derived from Cell Specific Gene Signatures Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)38543-9  1
2019 Li D, Haritunians T, Mengesha E, Targan SR, McGovern D. 151 – Using Deeplearning and Genetic Bigdata to Predict Crohn's Disease Gastroenterology. 156. DOI: 10.1016/S0016-5085(19)36864-7  1
2018 Castellanos JG, Woo V, Viladomiu M, Putzel G, Lima S, Diehl GE, Marderstein AR, Gandara J, Perez AR, Withers DR, Targan SR, Shih DQ, Scherl EJ, Longman RS. Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis. Immunity. PMID 30552020 DOI: 10.1016/J.Immuni.2018.10.014  1
2018 Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunology. PMID 29988118 DOI: 10.1038/S41385-018-0055-Y  1
2018 Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology. 5: 669-677.e2. PMID 29930984 DOI: 10.1016/J.Jcmgh.2017.12.008  1
2018 Lee CK, Melmed GY, Mann A, Danovitch I, Hedrick R, McGovern DPB, Targan S, Shih D, Vasiliauskas E, IsHak WW, Feldman E. A Multidisciplinary Approach to Biopsychosocial Care for Adults With Inflammatory Bowel Disease: A Pilot Study. Inflammatory Bowel Diseases. PMID 29920581 DOI: 10.1093/Ibd/Izy215  1
2018 Li D, Haritunians T, Landers C, Potdar AA, Yang S, Huang H, Schumm LP, Daly M, Targan SR, McGovern DPB. Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics. Inflammatory Bowel Diseases. PMID 29860388 DOI: 10.1093/Ibd/Izy148  1
2018 Sandborn WJ, Rutgeerts P, Gasink C, Jacobstein D, Zou B, Johanns J, Sands BE, Hanauer SB, Targan S, Ghosh S, de Villiers WJS, Colombel JF, Feagan BG. Long-term efficacy and safety of ustekinumab for Crohn's disease through the second year of therapy. Alimentary Pharmacology & Therapeutics. PMID 29797519 DOI: 10.1111/apt.14794  1
2018 Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, ... ... Targan S, et al. Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population. Plos Genetics. 14: e1007329. PMID 29795570 DOI: 10.1371/Journal.Pgen.1007329  1
2018 Rolston VS, Patel AV, Learch TJ, Li D, Karayev D, Williams C, Siddanthi ML, Targan SR, Weisman MH, McGovern DPB. Prevalence and Associations of Avascular Necrosis of the Hip in a Large Well-characterized Cohort of Patients With Inflammatory Bowel Disease. Journal of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases. PMID 29794876 DOI: 10.1097/Rhu.0000000000000797  1
2018 Clerc F, Novokmet M, Dotz V, Reiding KR, de Haan N, Kammeijer GSM, Dalebout H, Bladergroen MR, Vukovic F, Rapp E, Targan SR, Barron G, Manetti N, Latiano A, et al. Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases. Gastroenterology. 155: 829-843. PMID 29792883 DOI: 10.1053/J.Gastro.2018.05.030  1
2018 Sands BE, Han C, Gasink C, Jacobstein D, Szapary P, Gao LL, Lang Y, Targan S, Sandborn WJ, Feagan BG. The Effects of Ustekinumab on Health-Related Quality of Life in Patients with Moderate to Severe Crohn's Disease. Journal of Crohn's & Colitis. PMID 29726939 DOI: 10.1093/Ecco-Jcc/Jjy055  1
2018 Šimurina M, de Haan N, Vučković F, Kennedy NA, Štambuk J, Falck D, Trbojević-Akmačić I, Clerc F, Razdorov G, Khon A, Latiano A, D'Incà R, Danese S, Targan S, Landers C, et al. Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases. Gastroenterology. PMID 29309774 DOI: 10.1053/J.Gastro.2018.01.002  1
2018 Castellanos JG, Woo V, Viladomiu M, Putzel G, Diehl G, Scherl E, Targan SR, Shih DQ, Longman RS. P075 Microbial Induction Of Tl1A Links Protective And Pathogenic Roles For Group 3 Innate Lymphoid Cells In Colitis Gastroenterology. 154. DOI: 10.1053/J.Gastro.2017.11.115  1
2018 Lee CK, Li D, Haritunians T, Targan SR, Melmed G, McGovern D. Tu1821 - Multi-Omics Analyses in Crohn's Disease do not Incrementally Predict Poor Outcomes over Endoscopic and Serologic Variables Gastroenterology. 154. DOI: 10.1016/S0016-5085(18)33447-4  1
2018 Gu P, Dube S, Ko JZ, Li D, Haritunians T, Vasiliauskas E, Syal G, Bonthala N, Yang S, Fleshner P, Melmed G, Targan SR, McGovern D. Sa1809 - Clinical, Serologic, and Genetic Markers are Associated with Complicated Disease Behavior in Patients with Crohn's Disease (CD) Gastroenterology. 154. DOI: 10.1016/S0016-5085(18)31633-0  1
2018 Khrom M, Potdar AA, Mengesha E, Li D, Targan SR, McGovern D, Haritunians T. 592 - Gender-Stratified Analyses Identifies Sex-Specific IBD Associations Gastroenterology. 154. DOI: 10.1016/S0016-5085(18)30845-X  1
2017 Li H, Song J, Niu G, Zhang H, Guo J, Shih DQ, Targan SR, Zhang X. TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice. Pathology, Research and Practice. PMID 29254800 DOI: 10.1016/J.Prp.2017.11.017  1
2017 Gu P, Kapur A, Li D, Haritunians T, Vasiliauskas E, Shih DQ, Targan SR, Spiegel BMR, McGovern DPB, Black JT, Melmed GY. Serologic, Genetic, and Clinical Associations with Increased Healthcare Resource Utilization in Inflammatory Bowel Disease. Journal of Digestive Diseases. PMID 29251413 DOI: 10.1111/1751-2980.12566  1
2017 Yoon SM, Haritunians T, Chhina S, Liu Z, Yang S, Landers C, Li D, Ye BD, Shih D, Vasiliauskas EA, Ippoliti A, Rabizadeh S, Targan SR, Melmed GY, McGovern DPB. Colonic Phenotypes Are Associated with Poorer Response to Anti-TNF Therapies in Patients with IBD. Inflammatory Bowel Diseases. PMID 28590340 DOI: 10.1097/Mib.0000000000001150  1
2017 Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DP, Targan SR. Association of RNASET2 Gene Polymorphisms with Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease. Gastroenterology. PMID 28400196 DOI: 10.1053/J.Gastro.2017.04.002  1
2017 Feagan BG, Gasink C, Pollack P, Jacobstein D, Gao LL, Johanns J, Miao Y, Targan S, Ghosh S. P549 Effect of maintenance Ustekinumab on corticosteroid-free clinical outcomes in patients with Crohn's disease. Journal of Crohn's & Colitis. 11: S359-S360. PMID 28175147 DOI: 10.1093/ecco-jcc/jjx002.673  1
2017 Sandborn W, Rutgeerts P, Gasink C, Jacobstein D, Gao LL, Johanns J, Sands B, Hanauer SB, Targan S, Ghosh S, de Villiers WJ, Colombel JF, Feagan BG. OP010 Long term efficacy and safety of Ustekinumab for Crohn's disease: results from IM-UNITI long-term extension through 2 years. Journal of Crohn's & Colitis. 11: S6. PMID 28172686 DOI: 10.1093/ecco-jcc/jjx002.009  1
2017 Zhang H, Zheng L, McGovern DP, Hamill AM, Ichikawa R, Kanazawa Y, Luu J, Kumagai K, Cilluffo M, Fukata M, Targan SR, Underhill DM, Zhang X, Shih DQ. Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis. Journal of Immunology (Baltimore, Md. : 1950). PMID 28130498 DOI: 10.4049/Jimmunol.1601293  1
2017 Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, ... ... Targan SR, et al. Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis. The Journal of Experimental Medicine. PMID 28082357 DOI: 10.1084/Jem.20160791  1
2017 Potdar AA, Li D, Haritunians T, McGovern D, Targan SR, Bilsborough J. Expression Data From Crohn’s Disease Small Bowel Resections Indicate Distinct Clinical Sub-Groups Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)32165-0  1
2017 Zhu L, Melmed G, Yan X, Haritunians T, Shih DQ, Vasiliauskas E, Ippoliti A, Rabizadeh S, Singh N, Targan SR, Liu Z, Li D, McGovern D. UBE2L3, ANCA, ASCA, and CBIR1 are Associated with Mechanisms of non-Response to Anti-TNF in IBD Patients with Adequate Drug Levels Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)31514-7  1
2017 Gu P, Ko JZ, Yan X, Li D, Haritunians T, Vasiliauskas E, Targan SR, Melmed G, McGovern D, Shih DQ. Serologic and Genetic Markers May Help Predict Disease Behavior in Patients with Crohn'S Disease (CD) Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)31467-1  1
2017 Haritunians T, Li D, Liu Z, Khrom M, Fleshner P, Targan SR, McGovern D. Genetic Associations with Visceral Fat Deposition in Crohn'S Disease Gastroenterology. 152. DOI: 10.1016/S0016-5085(17)31458-0  1
2016 Thomas LS, Targan SR, Tsuda M, Yu QT, Salumbides BC, Haritunians T, Mengesha E, McGovern DP, Michelsen KS. The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction. Journal of Leukocyte Biology. PMID 27733581 DOI: 10.1189/Jlb.3A0316-129R  1
2016 Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, ... ... Targan SR, et al. Genome-wide Association Study Identifies African-Specific Susceptibility Loci in African Americans with Inflammatory Bowel Disease. Gastroenterology. PMID 27693347 DOI: 10.1053/J.Gastro.2016.09.032  1
2016 Jacob N, Targan SR, Shih DQ. Cytokine and anti-cytokine therapies in prevention or treatment of fibrosis in IBD. United European Gastroenterology Journal. 4: 531-40. PMID 27536363 DOI: 10.1177/2050640616649356  1
2016 Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, ... ... Targan SR, et al. A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition. Gastroenterology. PMID 27492617 DOI: 10.1053/J.Gastro.2016.06.051  1
2016 Targan SR, Feagan B, Vermeire S, Panaccione R, Melmed GY, Landers C, Li D, Russell C, Newmark R, Zhang N, Chon Y, Hsu YH, Lin SL, Klekotka P. A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn's Disease. The American Journal of Gastroenterology. PMID 27481309 DOI: 10.1038/Ajg.2016.298  1
2016 Robbins L, Zaghiyan K, Melmed G, Vasiliauskas E, Ahmed S, McGovern D, Rabizadeh S, Singh N, Landers C, Ippoliti A, Shih D, Targan S, Fleshner P. Outcomes with Anti-Tumor Necrosis Factor-Alpha Therapy and Serology in Patients with denovo Crohn's Disease after Ileal Pouch Anal Anastomosis. Journal of Crohn's & Colitis. PMID 27466172 DOI: 10.1093/Ecco-Jcc/Jjw134  1
2016 Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, ... ... Targan S, et al. A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GMCSF. Gastroenterology. PMID 27377463 DOI: 10.1053/J.Gastro.2016.06.045  1
2016 Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, et al. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science (New York, N.Y.). 352: 1116-20. PMID 27230380 DOI: 10.1126/Science.Aad9948  1
2016 Tran DY, Tran DN, Mattai SA, Sallam T, Ortiz C, Lee EC, Robbins L, Ho S, Lee JE, Fisseha E, Shieh C, Sideri A, Shih DQ, Fleshner P, McGovern DP, ... ... Targan SR, et al. Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. International Journal of Obesity (2005). PMID 27163748 DOI: 10.1038/Ijo.2016.90  1
2016 Li D, Silverberg MS, Haritunians T, Dubinsky MC, Landers C, Stempak JM, Milgrom R, Guo X, Chen YI, Rotter JI, Taylor KD, McGovern DP, Targan SR. TNFRSF1B Is Associated with ANCA in IBD. Inflammatory Bowel Diseases. PMID 27104820 DOI: 10.1097/Mib.0000000000000771  1
2016 Koh SZ, Zaghiyan KN, Li Q, Rabizadeh S, Melmed GY, Targan SR, Fleshner PR. Clinical Factors Associated with the Development of Crohn's Disease in Inflammatory Bowel Disease-unclassified Patients Undergoing Ileal Pouch-anal Anastomosis. Inflammatory Bowel Diseases. 22: 1397-402. PMID 26978722 DOI: 10.1097/Mib.0000000000000744  1
2016 Kaur M, Panikkath D, Yan X, Liu Z, Berel D, Li D, Vasiliauskas EA, Ippoliti A, Dubinsky M, Shih DQ, Melmed GY, Haritunians T, Fleshner P, Targan SR, McGovern DP. Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway. Inflammatory Bowel Diseases. PMID 26937622 DOI: 10.1097/Mib.0000000000000705  1
2016 Sandborn W, Gasink C, Blank M, Lang Y, Johanns J, Gao LL, Sands B, Hanauer S, Feagan B, Targan S, Ghosh S, de Villiers W, Colombel JF, Lee S, Desreumaux P, et al. O-001 A Multicenter, Double-Blind, Placebo-Controlled Phase3 Study of Ustekinumab, a Human IL-12/23P40 mAB, in Moderate-Service Crohn's Disease Refractory to Anti-TFNα: UNITI-1. Inflammatory Bowel Diseases. 22: S1. PMID 26849718 DOI: 10.1097/Mib.0000000000000720  1
2016 Sidhu-Varma M, Shih DQ, Targan SR. Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis. Inflammatory Bowel Diseases. 22: 548-59. PMID 26818423 DOI: 10.1097/Mib.0000000000000653  1
2016 Li D, Huang H, Haritunians T, Rabizadeh S, Daly MJ, Targan S, McGovern D. Su1855 Genetic Burden Analysis Identified Late-Onset Crohn's Disease(CD) As a Distinct Subgroup Characterized by Low Genetic Burden, UC-Like Serological Markers, Mild Clinical Phenotypes and High Proportion of Smoking Cessation at Diagnosis Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)31954-0  1
2016 Sandborn W, Feagan BG, Gasink C, Jacobstein D, Gao L, Johanns J, Sands BE, Hanauer SB, Targan S, Ghosh S, Villiers WJd, Colombel J, Lee S, Dieleman LA, Katz S, et al. 768 A Phase 3 Randomized, Multicenter, Double-Blind, Placebo-Controlled Study of Ustekinumab Maintenance Therapy in Moderate - Severe Crohn's Disease Patients: Results From IM-UNITI Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)30623-0  1
2016 Yoon SM, Haritunians T, Chhina S, Ye BD, Shih DQ, Vasiliauskas E, Ippoliti A, Targan S, Melmed GY, McGovern D. 188 Factors Predicting Response to Anti-TNF Agents for Patients With Inflammatory Bowel Disease Gastroenterology. 150. DOI: 10.1016/S0016-5085(16)30289-X  1
2015 Ahmed S, Melmed G, McGovern D, Robbins LA, Shih D, Vasiliauskas E, Singh N, Rabidzadeh S, Ippoliti A, Targan S, Fleshner P. Nonbloody Diarrhea but Not Significant Weight Loss at Diagnosis Is Associated with the Development of Denovo Crohn's Disease After Ileal Pouch-anal Anastomosis for Ulcerative Colitis. Inflammatory Bowel Diseases. PMID 26595552 DOI: 10.1097/Mib.0000000000000630  1
2015 Taleban S, Li D, Targan SR, Ippoliti A, Brant SR, Cho JH, Duerr RH, Rioux JD, Silverberg MS, Vasiliauskas EA, Rotter JI, Haritunians T, Shih DQ, Dubinsky M, Melmed GY, et al. Ocular Manifestations in Inflammatory Bowel Disease are Associated with Other Extra-Intestinal Manifestations, Gender, and Genes Implicated in Other Immune-Related Traits. Journal of Crohn's & Colitis. PMID 26449790 DOI: 10.1093/Ecco-Jcc/Jjv178  1
2015 Taleban S, Van Oijen MG, Vasiliauskas EA, Fleshner PR, Shen B, Ippoliti AF, Targan SR, Melmed GY. Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis. Digestive Diseases and Sciences. PMID 26434930 DOI: 10.1007/S10620-015-3886-3  1
2015 Huang C, Haritunians T, Okou DT, Cutler DJ, Zwick ME, Taylor KD, Datta LW, Maranville JC, Liu Z, Ellis S, Chopra P, Alexander JS, Baldassano RN, Cross RK, Dassopoulos T, ... ... Targan SR, et al. Characterization of Genetic Loci That Affect Susceptibility to Inflammatory Bowel Diseases in African Americans. Gastroenterology. PMID 26278503 DOI: 10.1053/J.Gastro.2015.07.065  1
2015 Dezfoli S, Horton HA, Thepyasuwan N, Berel D, Targan SR, Vasiliauskas EA, Dubinsky M, Shih DQ, Kaur M, McGovern DP, Ippoliti A, Feldman EJ, Melmed GY. Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases. PMID 25985242 DOI: 10.1097/Mib.0000000000000448  1
2015 Weizman AV, Huang B, Targan S, Dubinsky M, Fleshner P, Kaur M, Ippoliti A, Panikkath D, Vasiliauskas E, Shih D, McGovern DP, Melmed GY. Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study. Journal of Cutaneous Medicine and Surgery. 19: 125-31. PMID 25775631 DOI: 10.2310/7750.2014.14053  1
2015 Hyun J, Romero L, Riveron R, Flores C, Kanagavelu S, Chung KD, Alonso A, Sotolongo J, Ruiz J, Manukyan A, Chun S, Singh G, Salas P, Targan SR, Fukata M. Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk. Journal of Innate Immunity. 7: 87-101. PMID 25171731 DOI: 10.1159/000365417  1
2015 Lau C, Dubinsky M, Melmed G, Vasiliauskas E, Berel D, McGovern D, Ippoliti A, Shih D, Targan S, Fleshner P. The impact of preoperative serum anti-TNFα therapy levels on early postoperative outcomes in inflammatory bowel disease surgery. Annals of Surgery. 261: 487-96. PMID 24950263 DOI: 10.1097/Sla.0000000000000757  1
2015 Robbins L, Yan X, Chhina S, Dailey F, Pan D, Haritunians T, Shih D, Ippoliti A, Vasiliauskas E, Melmed G, Targan S, McGovern D. Psoriasis in Inflammatory Bowel Disease (IBD) Patients Is Associated With Erythema Nodosum and IBD-Associated Genes, But Is Less Prevalent in Patients Taking Anti-TNF Therapies Presidential Poster: 1981 The American Journal of Gastroenterology. 110. DOI: 10.14309/00000434-201510001-01981  1
2014 Halloran B, Chang J, Shih DQ, McGovern D, Famulski K, Evaschesen C, Fedorak RN, Thiesen A, Targan S, Halloran PF. Molecular patterns in human ulcerative colitis and correlation with response to infliximab. Inflammatory Bowel Diseases. 20: 2353-63. PMID 25397893 DOI: 10.1097/Mib.0000000000000239  1
2014 Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cells Translational Medicine. 3: 1429-34. PMID 25298370 DOI: 10.5966/Sctm.2014-0121  1
2014 Khanna PV, Shih DQ, Haritunians T, McGovern DP, Targan S. Use of animal models in elucidating disease pathogenesis in IBD. Seminars in Immunopathology. 36: 541-51. PMID 25212688 DOI: 10.1007/S00281-014-0444-6  1
2014 Gonsky R, Deem RL, Landers CJ, Haritunians T, Yang S, Targan SR. IFNG rs1861494 polymorphism is associated with IBD disease severity and functional changes in both IFNG methylation and protein secretion. Inflammatory Bowel Diseases. 20: 1794-801. PMID 25171510 DOI: 10.1097/Mib.0000000000000172  1
2014 Alexander KL, Targan SR, Elson CO. Microbiota activation and regulation of innate and adaptive immunity. Immunological Reviews. 260: 206-20. PMID 24942691 DOI: 10.1111/Imr.12180  1
2014 Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J. Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function. Journal of Immunology (Baltimore, Md. : 1950). 193: 940-9. PMID 24935928 DOI: 10.4049/Jimmunol.1400093  1
2014 Horton HA, Dezfoli S, Berel D, Hirsch J, Ippoliti A, McGovern D, Kaur M, Shih D, Dubinsky M, Targan SR, Fleshner P, Vasiliauskas EA, Grein J, Murthy R, Melmed GY. Antibiotics for Treatment of Clostridium difficile Infection in Hospitalized Patients with Inflammatory Bowel Disease. Antimicrobial Agents and Chemotherapy. 58: 5054-9. PMID 24913174 DOI: 10.1128/Aac.02606-13  1
2014 Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR. Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis. Mucosal Immunology. 7: 1492-503. PMID 24850426 DOI: 10.1038/Mi.2014.37  1
2014 Weizman A, Huang B, Berel D, Targan SR, Dubinsky M, Fleshner P, Ippoliti A, Kaur M, Panikkath D, Brant S, Oikonomou I, Duerr R, Rioux J, Silverberg M, Rotter JI, et al. Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients. Inflammatory Bowel Diseases. 20: 525-33. PMID 24487271 DOI: 10.1097/01.Mib.0000442011.60285.68  1
2014 Vu MP, Melmed GY, Targan SR. Weeding out the facts: The reality about cannabis and crohn's disease Clinical Gastroenterology and Hepatology. 12: 898-899. PMID 24269921 DOI: 10.1016/J.Cgh.2013.11.016  1
2014 VanDussen KL, Liu TC, Li D, Towfic F, Modiano N, Winter R, Haritunians T, Taylor KD, Dhall D, Targan SR, Xavier RJ, McGovern DP, Stappenbeck TS. Genetic variants synthesize to produce paneth cell phenotypes that define subtypes of Crohn's disease. Gastroenterology. 146: 200-9. PMID 24076061 DOI: 10.1053/J.Gastro.2013.09.048  1
2014 Chhina S, Steadman K, Goel G, Nguyen K, Targan S, Li X, Haritunians T, Li D, Yang S, McGovern D. Small Bowel Location, Stricturing Behavior, Vitamin D Receptor Polymorphism, and Metabolic Disease Susceptibility Genes Are Associated With NAFLD in Crohn’s Disease: 1704 The American Journal of Gastroenterology. 109. DOI: 10.14309/00000434-201410002-01704  1
2014 Fu N, Yan X, Haritunians T, Targan S, Melmed GY, Vasiliauskas EA, McGovern DP. Mo1242 Genetic, Serological and Clinical Associations in Inflammatory Bowel Disease (IBD) Patients With Clostridium difficile Infection (CDI) Gastroenterology. 146. DOI: 10.1016/S0016-5085(14)62157-0  1
2014 Wallace KL, Zheng L, Kanazawa Y, Zhang H, Ichikawa R, Chen J, Sidhu M, Zhang X, Pothoulakis C, Koon HW, Targan S, Shih DQ. 783 TL1A Modulates the Differential Effect of IL-17 Blockade on Mucosal Inflammation Gastroenterology. 146. DOI: 10.1016/S0016-5085(14)60471-6  1
2014 Haritunians T, Li D, Yan X, Mengesha E, Rich SS, Onengut-Gumuscu S, Chen W, Shih DQ, Li X, McGovern JF, Ippoliti A, Dubinsky M, Vasiliauskas EA, Melmed GY, Fleshner P, ... Targan S, et al. 127 Genetic Variation Associated Medically Refractory Ulcerative Colitis Requiring Colectomy Gastroenterology. 146. DOI: 10.1016/S0016-5085(14)60122-0  1
2013 Wallis D, Asaduzzaman A, Weisman M, Haroon N, Anton A, McGovern D, Targan S, Inman R. Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitis: an observational study. Arthritis Research & Therapy. 15: R166. PMID 24286190 DOI: 10.1186/Ar4350  1
2013 Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ. Erratum: Sustained TL1A (TNFSF15) expression on both lymphoid and myeloid cells leads to mild spontaneous intestinal inflammation and fibrosis (DOI: 10.1556/EuJMI.3.2013.1.2). European Journal of Microbiology & Immunology. 3: 141. PMID 24265931 DOI: 10.1556/Eujmi.3.2013.2.8  1
2013 Dubinsky MC, Kugathasan S, Kwon S, Haritunians T, Wrobel I, Wahbeh G, Quiros A, Bahar R, Silber G, Farrior S, Stephens M, Teleten N, Panikkath D, Ippoliti A, Vasiliauskas E, ... ... Targan SR, et al. Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease. Inflammatory Bowel Diseases. 19: 1662-70. PMID 23665963 DOI: 10.1097/Mib.0B013E318281F275  1
2013 Gonsky R, Deem RL, Targan SR. Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells. Cytokine. 63: 36-42. PMID 23642711 DOI: 10.1016/J.Cyto.2013.04.004  1
2013 Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ. SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS. European Journal of Microbiology & Immunology. 3: 11-20. PMID 23638306 DOI: 10.1556/Eujmi.3.2013.1.2  1
2013 Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR, Pothoulakis C. Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes. Antimicrobial Agents and Chemotherapy. 57: 3214-23. PMID 23629713 DOI: 10.1128/Aac.02633-12  1
2013 Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR. HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses Inflammatory Bowel Diseases. 19: 151-164. PMID 23292349 DOI: 10.1002/Ibd.22983  1
2013 Surti B, Spiegel B, Ippoliti A, Vasiliauskas EA, Simpson P, Shih DQ, Targan SR, McGovern DP, Melmed GY. Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale. Digestive Diseases and Sciences. 58: 1313-21. PMID 23250673 DOI: 10.1007/S10620-012-2500-1  1
2013 Sandborn WJ, Targan SR, Byers VS, Rutty DA, Mu H, Zhang X, Tang T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. The American Journal of Gastroenterology. 108: 90-8. PMID 23044768 DOI: 10.1038/Ajg.2012.340  1
2013 Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut. 62: 1295-305. PMID 22760006 DOI: 10.1136/Gutjnl-2012-302180  1
2013 Le Q, Melmed G, Dubinsky M, McGovern D, Vasiliauskas EA, Murrell Z, Ippoliti A, Shih D, Kaur M, Targan S, Fleshner P. Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn's disease. Inflammatory Bowel Diseases. 19: 30-6. PMID 22467562 DOI: 10.1002/Ibd.22955  1
2013 Wallis D, Weisman M, Haroon N, Anton A, Govern DM, Targan S, Inman R. OP0241 Anti-Flagellin Antibodies in Ankylosing Spondylitis (AS) Implicate Subclinical Bowel Inflammation and Differentiate as from Mechanical Back Pain Patients Annals of the Rheumatic Diseases. 72. DOI: 10.1136/Annrheumdis-2013-Eular.446  1
2013 Haritunians T, Li D, Liu Z, Yan X, Eric V, Ippoliti A, Dubinsky M, Shih D, Melmed G, Fleshner P, Targan S, McGovern D. P-218 Exome Chip Analysis of Perianal Crohn’s Disease Identifies Novel Loci Not Previously Described using Immunochip Platform Inflammatory Bowel Diseases. 19. DOI: 10.1097/01.Mib.0000439016.44908.3D  1
2013 Zhang X, Li H, Shih DQ, Song J, Niu G, Zhang H, Peng C, Targan SR. Tu1650 Constitutive TL1A Expression Modulates Colonic Fibrosis on TNBS-Induced Colitis in Mice Gastroenterology. 144. DOI: 10.1016/S0016-5085(13)63019-X  1
2013 Gerich ME, Fleshner P, Panikkath D, Winter R, Yoon JL, Ocampo LH, Al-Jiboury H, Kwon S, Haritunians T, Berel D, Dubinsky M, Targan SR, Melmed GY, McGovern DP. Mo1299 Genotype and Post-Operative Immunosuppression Impact Surgical Recurrence in Crohn's Disease Gastroenterology. 144. DOI: 10.1016/S0016-5085(13)62332-X  1
2013 Zheng L, Zhang X, Ichikawa R, Chen J, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ. 735 Distinct Effects of IFN-γ and IL-17A on TL1A-Modulated Murine Regional Inflammation and Fibrosis Gastroenterology. 144. DOI: 10.1016/S0016-5085(13)60475-8  1
2012 Matzkies FG, Targan SR, Berel D, Landers CJ, Reveille JD, McGovern DP, Weisman MH. Markers of intestinal inflammation in patients with ankylosing spondylitis: a pilot study. Arthritis Research & Therapy. 14: R261. PMID 23194008 DOI: 10.1186/Ar4106  1
2012 Salehi S, Bankoti R, Benevides L, Willen J, Couse M, Silva JS, Dhall D, Meffre E, Targan S, Martins GA. B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 189: 5682-93. PMID 23162130 DOI: 10.4049/Jimmunol.1201966  1
2012 Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, ... ... Targan SR, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 491: 119-24. PMID 23128233 DOI: 10.1038/Nature11582  1
2012 Sandborn WJ, Gasink C, Gao LL, Blank MA, Johanns J, Guzzo C, Sands BE, Hanauer SB, Targan S, Rutgeerts P, Ghosh S, de Villiers WJ, Panaccione R, Greenberg G, Schreiber S, et al. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. The New England Journal of Medicine. 367: 1519-28. PMID 23075178 DOI: 10.1056/Nejmoa1203572  1
2012 White EC, Melmed GY, Vasiliauskas E, Dubinsky M, Ippoliti A, McGovern D, Targan S, Fleshner P. Does preoperative immunosuppression influence unplanned hospital readmission after surgery in patients with Crohn's disease? Diseases of the Colon and Rectum. 55: 563-8. PMID 22513435 DOI: 10.1097/Dcr.0B013E3182468961  1
2012 Sandborn WJ, Colombel JF, Sands BE, Rutgeerts P, Targan SR, Panaccione R, Bressler B, Geboes K, Schreiber S, Aranda R, Gujrathi S, Luo A, Peng Y, Salter-Cid L, Hanauer SB. Abatacept for Crohn's disease and ulcerative colitis. Gastroenterology. 143: 62-69.e4. PMID 22504093 DOI: 10.1053/J.Gastro.2012.04.010  1
2012 Basseri RJ, Basseri B, Vassilaki ME, Melmed GY, Ippoliti A, Vasiliauskas EA, Fleshner PR, Lechago J, Hu B, Berel D, Targan SR, Papadakis KA. Colorectal cancer screening and surveillance in Crohn's colitis. Journal of Crohn's & Colitis. 6: 824-9. PMID 22398087 DOI: 10.1016/J.Crohns.2012.01.005  1
2012 Murdoch TB, Xu W, Stempak JM, Landers C, Targan SR, Rotter JI, Silverberg MS. Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease. Inflammatory Bowel Diseases. 18: 1743-8. PMID 22275320 DOI: 10.1002/Ibd.22884  1
2012 Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. The American Journal of Pathology. 180: 636-49. PMID 22138299 DOI: 10.1016/J.Ajpath.2011.10.026  1
2012 Winter R, Li D, Dubinsky M, Targan S, Taylor K, Rotter J, Haritunians T, McGovern D. Association of Vitamin D and Genetic Variation in IBD: 1696 The American Journal of Gastroenterology. 107. DOI: 10.14309/00000434-201210001-01696  1
2012 Shih D, Zheng L, Zhang X, Chen J, Ichikawa R, Pothoulakis C, Koon HW, Targan S. Autophagy is Involved in Optimal Expression of TL1A (TNFSF15) by Microbes in Primary Human Monocytes: P-246 Inflammatory Bowel Diseases. 18. DOI: 10.1097/00054725-201212001-00279  1
2012 Gingold D, McGovern DP, Li D, Haritunians T, Melmed GY, Dubinsky M, Vasiliauskas EA, Ippoliti A, Kaur M, Shih DQ, Rotter JI, Taylor KD, Targan SR, Fleshner P. Tu1910 Prospective Evaluation of Genetic Determinants of Surgical Outcome After Ileal Pouch-Anal Anastomosis (IPAA) Gastroenterology. 142. DOI: 10.1016/S0016-5085(12)63397-6  1
2012 Vu M, Li D, Dubinsky M, Taylor KD, Haritunians T, Dutridge D, Rotter JI, Targan SR, McGovern DP. Tu1907 Gene-Smoking Interactions in Inflammatory Bowel Disease Gastroenterology. 142. DOI: 10.1016/S0016-5085(12)63394-0  1
2012 Shih DQ, Zhang X, Koon HW, Chang J, Chen J, Huang BL, Li C, Zheng L, Pothoulakis C, Targan SR. 357 Reversal of Murine Colitis and Fibrosis by Neutralizing TL1A Antibody: Potential Novel Therapy to Alter Natural History of Crohn's Disease Gastroenterology. 142. DOI: 10.1016/S0016-5085(12)60318-7  1
2012 Huang BL, Weizman AV, Berel D, Shih DQ, Targan SR, Dubinsky M, Li D, Kaur M, Haritunians T, Taylor KD, Melmed GY, McGovern DP. 29 Inflammatory Bowel Disease and Erythema Nodosum: Clinical, Serologic, and Genetic Associations Gastroenterology. 142. DOI: 10.1016/S0016-5085(12)60029-8  1
2011 Cohavy O, Shih DQ, Doherty TM, Ware CF, Targan SR. CD161 DEFINES EFFECTOR T CELLS THAT EXPRESS LIGHT AND RESPOND TO TL1A-DR3 SIGNALING. European Journal of Microbiology & Immunology. 1: 70-79. PMID 22348196 DOI: 10.1556/Eujmi.1.2011.1.9  1
2011 Koon HW, Shih DQ, Hing TC, Chen J, Ho S, Zhao D, Targan SR, Pothoulakis C. Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells. The American Journal of Pathology. 179: 2315-26. PMID 21945803 DOI: 10.1016/J.Ajpath.2011.07.038  1
2011 Koon HW, Shih DQ, Chen J, Bakirtzi K, Hing TC, Law I, Ho S, Ichikawa R, Zhao D, Xu H, Gallo R, Dempsey P, Cheng G, Targan SR, Pothoulakis C. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology. 141: 1852-63.e1-3. PMID 21762664 DOI: 10.1053/J.Gastro.2011.06.079  1
2011 Bernstein CN, El-Gabalawy H, Sargent M, Landers CJ, Rawsthorne P, Elias B, Targan SR. Assessing inflammatory bowel disease-associated antibodies in Caucasian and First Nations cohorts Canadian Journal of Gastroenterology. 25: 269-273. PMID 21647462 DOI: 10.1155/2011/712350  1
2011 Kwan LY, Targan SR, Shih DQ. A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease. World Journal of Gastroenterology. 17: 2446-9. PMID 21633646 DOI: 10.3748/Wjg.V17.I19.2446  1
2011 Plevy SE, Targan SR. Future therapeutic approaches for inflammatory bowel diseases. Gastroenterology. 140: 1838-46. PMID 21530750 DOI: 10.1053/J.Gastro.2011.02.014  1
2011 Lichtenstein GR, Targan SR, Dubinsky MC, Rotter JI, Barken DM, Princen F, Carroll S, Brown M, Stachelski J, Chuang E, Landers CJ, Stempak JM, Singh S, Silverberg MS. Combination of genetic and quantitative serological immune markers are associated with complicated Crohn's disease behavior. Inflammatory Bowel Diseases. 17: 2488-96. PMID 21391291 DOI: 10.1002/Ibd.21661  1
2011 Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, ... ... Targan SR, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nature Genetics. 43: 246-52. PMID 21297633 DOI: 10.1038/Ng.764  1
2011 Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, Martins G, Pothoulakis C, Targan SR. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. Plos One. 6: e16090. PMID 21264313 DOI: 10.1371/Journal.Pone.0016090  1
2011 Haritunians T, Jones MR, McGovern DP, Shih DQ, Barrett RJ, Derkowski C, Dubinsky MC, Dutridge D, Fleshner PR, Ippoliti A, King L, Leshinsky-Silver E, Levine A, Melmed GY, Mengesha E, ... ... Targan SR, et al. Variants in ZNF365 isoform D are associated with Crohn's disease. Gut. 60: 1060-7. PMID 21257989 DOI: 10.1136/Gut.2010.227256  1
2011 Shih DQ, Michelsen KS, Barrett RJ, Biener-Ramanujan E, Gonsky R, Zhang X, Targan SR. Insights into TL1A and IBD pathogenesis. Advances in Experimental Medicine and Biology. 691: 279-88. PMID 21153332 DOI: 10.1007/978-1-4419-6612-4_29  1
2011 Targan SR. Introductory words about TL1A/DR3. Advances in Experimental Medicine and Biology. 691: 271-4. PMID 21153330 DOI: 10.1007/978-1-4419-6612-4_27  0.01
2011 Sarnaik AA, Yu B, Yu D, Morelli D, Hall M, Bogle D, Yan L, Targan S, Solomon J, Nichol G, Yellin M, Weber JS. Extended dose ipilimumab with a peptide vaccine: Immune correlates associated with clinical benefit in patients with resected high-risk stage IIIc/IV melanoma Clinical Cancer Research. 17: 896-906. PMID 21106722 DOI: 10.1158/1078-0432.Ccr-10-2463  1
2011 Yu JE, De Ravin SS, Uzel G, Landers C, Targan S, Malech HL, Holland SM, Cao W, Harpaz N, Mayer L, Cunningham-Rundles C. High levels of Crohn's disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease. Clinical Immunology (Orlando, Fla.). 138: 14-22. PMID 20956091 DOI: 10.1016/J.Clim.2010.08.003  1
2011 Gonsky R, Deem RL, Landers CJ, Derkowski CA, Berel D, McGovern DP, Targan SR. Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens. Inflammatory Bowel Diseases. 17: 171-8. PMID 20848535 DOI: 10.1002/Ibd.21352  1
2011 McGovern DPB, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RTH, Lagace C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, ... ... Targan SR, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci (vol 42, pg 332, 2010) Nature Genetics. 43: 388-388. DOI: 10.1038/Ng0411-388C  1
2011 Gonsky R, Deem R, McGovern DP, Haritunians T, Taylor KD, Targan SR. An IFNG SNP Within a Linkage Disequilibrium Block Associated With UC and Severity is Functionally Associated With Altered IFNG Methylation and IFN-γ Protein Secretion Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)63464-1  1
2011 Modiano N, Fleshner P, Taylor KD, Dubinsky M, Vasiliauskas EA, Ippoliti A, Shih DQ, Melmed GY, Targan SR, Berel D, Haritunians T, Rotter JI, McGovern DP. Intestinal Granulomas in Crohn's Disease: Association With Patient Characteristics, Serologic Markers, and Genetics Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)61996-3  1
2011 Nguyen M, Bradford K, Huang BL, Haritunians T, Fleshner P, Himmelfarb E, Landers CJ, Vasiliauskas EA, Ippoliti A, Melmed GY, Dubinsky M, Gonsky R, Rotter JI, Targan SR, McGovern DP, et al. Genetic Predictors of Cytomegalovirus Infection in Patients With Inflammatory Bowel Disease Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)61091-3  1
2011 Taylor KD, Haritunians T, McGovern DP, Landers CJ, Ippoliti A, Vasiliauskas EA, Guo X, Dubinsky M, Targan SR, Rotter JI. Genome-Wide Association Study of CD-Associated Anti-Microbial Antibodies Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)61084-6  1
2011 Haritunians T, Taylor KD, McGovern DP, Landers CJ, Guo X, Dubinsky M, Fleshner P, Rotter JI, Targan SR. Two Distinct Loci on Chromosome 4 Affect Antibody Expression in UC Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)61083-4  1
2011 Essers JB, Cole EB, Dubinsky M, Haritunians T, Korzenik JR, McGovern DP, Sands BE, Targan SR, Taylor KD, Teleten N, Xavier RJ, Daly MJ, Rotter JI, Silverberg MS. The Utility of Genetics in Classifying Ulcerative Colitis and Crohn's Disease Patients Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)61074-3  1
2011 Choi JM, McGovern DP, Lee ES, Berel D, Kwon S, Landers CJ, Haritunians T, Targan SR, Rotter JI, Taylor KD, Dubinsky M. Predictors of Therapeutic Remission to Thiopurines in Pediatric Inflammatory Bowel Disease Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)60623-9  1
2011 Siegel CA, Fleshner P, Siegel LS, Rotter JI, Dubinsky M, Vasiliauskas EA, Ippoliti A, Shih DQ, Melmed GY, Landers CJ, Haritunians T, Targan SR, Taylor KD, McGovern DP. Predicting Crohn's Disease Post-Operative Recurrence Using Clinical, Endoscopic, Serologic and Genetic Factors Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)60622-7  1
2011 Barrett R, Zhang X, Yeager N, Koon HW, Nguyen MA, Phaosawasdi P, Li C, Pothoulakis C, Targan SR, Shih DQ. In Vivo Constitutive Expression of an IBD Associated Gene TNFSF15 Causes Severe Inflammation and Induces Fibrostenotic Disease in 2 Murine Models of Chronic Colitis Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)60612-4  1
2011 deFonseka AM, Haritunians T, Berel D, Targan SR, Landers CJ, Rotter JI, Vasiliauskas EA, Ippoliti A, Melmed GY, Shih DQ, Dubinsky M, Taylor KD, McGovern DP. Clinical, Serologic, and Genetic Associations With Low Bone Density in Patients With Inflammatory Bowel Disease Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)60021-8  1
2010 Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, ... ... Targan SR, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nature Genetics. 42: 1118-25. PMID 21102463 DOI: 10.1038/Ng.717  1
2010 Berman D, Parker SM, Siegel J, Chasalow SD, Weber J, Galbraith S, Targan SR, Wang HL. Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma. Cancer Immunity. 10: 11. PMID 21090563  0.01
2010 Sandborn WJ, Colombel JF, Frankel M, Hommes D, Lowder JN, Mayer L, Plevy S, Stokkers P, Travis S, Van Assche G, Baumgart DC, Targan SR. Anti-CD3 antibody visilizumab is not effective in patients with intravenous corticosteroid-refractory ulcerative colitis. Gut. 59: 1485-92. PMID 20947884 DOI: 10.1136/Gut.2009.205443  1
2010 Haritunians T, Taylor KD, Targan SR, Dubinsky M, Ippoliti A, Kwon S, Guo X, Melmed GY, Berel D, Mengesha E, Psaty BM, Glazer NL, Vasiliauskas EA, Rotter JI, Fleshner PR, et al. Genetic predictors of medically refractory ulcerative colitis. Inflammatory Bowel Diseases. 16: 1830-40. PMID 20848476 DOI: 10.1002/Ibd.21293  1
2010 McGovern DP, Jones MR, Taylor KD, Marciante K, Yan X, Dubinsky M, Ippoliti A, Vasiliauskas E, Berel D, Derkowski C, Dutridge D, Fleshner P, Shih DQ, Melmed G, Mengesha E, ... ... Targan SR, et al. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Human Molecular Genetics. 19: 3468-76. PMID 20570966 DOI: 10.1093/Hmg/Ddq248  1
2010 White E, Melmed GY, Vasiliauskas EA, Dubinsky M, Berel D, Targan SR, Fleshner PR. A prospective analysis of clinical variables, serologic factors, and outcome of ileal pouch-anal anastomosis in patients with backwash ileitis. Diseases of the Colon and Rectum. 53: 987-94. PMID 20551749 DOI: 10.1007/Dcr.0B013E3181Dcb3F2  1
2010 Biener-Ramanujan E, Gonsky R, Ko B, Targan SR. Functional signaling of membrane-bound TL1A induces IFN-gamma expression. Febs Letters. 584: 2376-80. PMID 20403353 DOI: 10.1016/J.Febslet.2010.04.030  1
2010 Heidemann SC, Chavez V, Landers CJ, Kucharzik T, Prehn JL, Targan SR. TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets Journal of Clinical Immunology. 30: 531-538. PMID 20349123 DOI: 10.1007/S10875-010-9382-9  1
2010 McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, ... ... Targan SR, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nature Genetics. 42: 332-7. PMID 20228799 DOI: 10.1038/Ng.549  1
2010 Melmed GY, Targan SR. Future biologic targets for IBD: potentials and pitfalls. Nature Reviews. Gastroenterology & Hepatology. 7: 110-7. PMID 20134493 DOI: 10.1038/Nrgastro.2009.218  1
2010 Ippoliti A, Devlin S, Mei L, Yang H, Papadakis KA, Vasiliauskas EA, McGovern DP, Abreu MT, Melmed G, Shaye O, Enayati P, Chen G, Choi J, Taylor K, Landers CJ, ... ... Targan SR, et al. Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease. Inflammatory Bowel Diseases. 16: 1279-85. PMID 20027650 DOI: 10.1002/Ibd.21196  1
2010 Dubinsky MC, Mei L, Friedman M, Dhere T, Haritunians T, Hakonarson H, Kim C, Glessner J, Targan SR, McGovern DP, Taylor KD, Rotter JI. Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease. Inflammatory Bowel Diseases. 16: 1357-66. PMID 20014019 DOI: 10.1002/Ibd.21174  1
2010 Melmed GY, Agarwal N, Frenck RW, Ippoliti AF, Ibanez P, Papadakis KA, Simpson P, Barolet-Garcia C, Ward J, Targan SR, Vasiliauskas EA. Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease. The American Journal of Gastroenterology. 105: 148-54. PMID 19755964 DOI: 10.1038/Ajg.2009.523  1
2010 Baumgart DC, Targan SR, Dignass AU, Mayer L, van Assche G, Hommes DW, Hanauer SB, Mahadevan U, Reinisch W, Plevy SE, Salzberg BA, Buchman AL, Mechkov GM, Krastev ZA, Lowder JN, et al. Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis. Inflammatory Bowel Diseases. 16: 620-9. PMID 19714757 DOI: 10.1002/Ibd.21084  1
2010 Yokota A, Takeuchi H, Ohoka Y, Song S, Iwata M, Villablanca EJ, Wang S, Gomes DC, Calisto Jd, Kane MA, Rossi-Bergmann B, Napoli JL, Blaner WS, Chen Y, Blomhoff R, ... ... Targan S, et al. Mucosal immunity: homeostasis (WS-064) Chairpersons: Toshiaki Ohteki, Makoto Iwata International Immunology. 22. DOI: 10.1093/Intimm/Dxq412  1
2010 Jones MR, Haritunians T, McGovern DP, Dubinsky M, Ippoliti A, Vasiliauskas EA, Melmed GY, Shih DQ, Fleshner P, Levine A, Leshinsky ES, Siscovick D, Marciante KD, Targan SR, Rotter JI, et al. W1213 Genome Wide Association Study in Ashkenazi Jewish Crohn's Disease Patients Reveals Novel Susceptibility Loci Gastroenterology. 138. DOI: 10.1016/S0016-5085(10)63106-X  1
2010 Nguyen M, Bradford K, Zhang X, Simpson P, Targan SR, Vasiliauskas EA, Shih DQ. 1004 Severity of Cytomegalovirus Infection on Pathology Specimens is Associated With Colectomy Rates and Response to Antiviral Therapy in Inflammatory Bowel Disease Patients Gastroenterology. 138. DOI: 10.1016/S0016-5085(10)60663-4  1
2010 Shih DQ, Barrett R, Zhang X, Ko B, Wong MH, Phaosawasdi P, Yeager N, Martins G, Takedatsu H, Michelsen KS, Targan SR. 85 Constitutive In Vivo Expression of TNFSF15 in Myeloid or Lymphoid Cells Induce Mild Small Bowel Inflammation in Mice Gastroenterology. 138. DOI: 10.1016/S0016-5085(10)60068-6  1
2010 Haritunians T, Jones MR, McGovern DP, Fleshner P, Ippoliti A, Dubinsky M, Vasiliauskas EA, Melmed GY, Shih DQ, Barrett R, Rotter JI, Targan SR, Taylor KD. 30 Variants in Znf365 on 10q21 are Associated With Crohn's Disease Gastroenterology. 138. DOI: 10.1016/S0016-5085(10)60024-8  1
2010 Karp LC, Targan SR. Heterogeneity of Inflammatory Bowel Diseases Inflammatory Bowel Disease: Translating Basic Science Into Clinical Practice. 3-8. DOI: 10.1002/9781444318418.ch2  1
2009 Shih DQ, Targan SR. Insights into IBD Pathogenesis. Current Gastroenterology Reports. 11: 473-80. PMID 19903423 DOI: 10.1007/S11894-009-0072-9  1
2009 Shih DQ, Kwan LY, Chavez V, Cohavy O, Gonsky R, Chang EY, Chang C, Elson CO, Targan SR. Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. European Journal of Immunology. 39: 3239-50. PMID 19839006 DOI: 10.1002/Eji.200839087  1
2009 Saruta M, Michelsen KS, Thomas LS, Yu QT, Landers CJ, Targan SR. TLR8-mediated activation of human monocytes inhibits TL1A expression European Journal of Immunology. 39: 2195-2202. PMID 19637197 DOI: 10.1002/Eji.200939216  1
2009 Murrell ZA, Melmed GY, Ippoliti A, Vasiliauskas EA, Dubinsky M, Targan SR, Fleshner PR. A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis. Diseases of the Colon and Rectum. 52: 872-8. PMID 19502850 DOI: 10.1007/Dcr.0B013E31819F5D4C  1
2009 Gonsky R, Deem RL, Targan SR. Distinct Methylation of IFNG in the Gut. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 29: 407-14. PMID 19450149 DOI: 10.1089/Jir.2008.0109  1
2009 Michelsen KS, Thomas LS, Taylor KD, Yu QT, Mei L, Landers CJ, Derkowski C, McGovern DP, Rotter JI, Targan SR. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. Plos One. 4: e4719. PMID 19262684 DOI: 10.1371/Journal.Pone.0004719  1
2009 Baumgart DC, Lowder JN, Targan SR, Sandborn WJ, Frankel MB. Transient cytokine-induced liver injury following administration of the humanized anti-CD3 antibody visilizumab (HuM291) in Crohn's disease. The American Journal of Gastroenterology. 104: 868-76. PMID 19240707 DOI: 10.1038/Ajg.2008.138  1
2009 McGovern DP, Rotter JI, Mei L, Haritunians T, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mengesha E, King L, Pressman S, Targan SR, Taylor KD. Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease. Inflammatory Bowel Diseases. 15: 883-9. PMID 19235914 DOI: 10.1002/Ibd.20855  1
2009 Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, ... ... Targan SR, et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nature Genetics. 41: 216-20. PMID 19122664 DOI: 10.1038/Ng.275  1
2009 Markowitz J, Kugathasan S, Dubinsky M, Mei L, Crandall W, LeLeiko N, Oliva-Hemker M, Rosh J, Evans J, Mack D, Otley A, Pfefferkorn M, Bahar R, Vasiliauskas E, Wahbeh G, ... ... Targan S, et al. Age of diagnosis influences serologic responses in children with Crohn's disease: a possible clue to etiology? Inflammatory Bowel Diseases. 15: 714-9. PMID 19107777 DOI: 10.1002/Ibd.20831  1
2009 Saruta M, Targan SR, Mei L, Ippoliti AF, Taylor KD, Rotter JI. High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females. Inflammatory Bowel Diseases. 15: 321-7. PMID 18942751 DOI: 10.1002/Ibd.20754  1
2009 Takedatsu H, Taylor KD, Mei L, McGovern DP, Landers CJ, Gonsky R, Cong Y, Vasiliauskas EA, Ippoliti A, Elson CO, Rotter JI, Targan SR. Linkage of Crohn's disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation. Gut. 58: 60-7. PMID 18832525 DOI: 10.1136/Gut.2008.156422  1
2009 McGovern DP, Taylor KD, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mei L, Mengesha E, King L, Pressman S, Targan SR, Rotter JI. MAGI2 genetic variation and inflammatory bowel disease. Inflammatory Bowel Diseases. 15: 75-83. PMID 18720471 DOI: 10.1002/Ibd.20611  1
2009 Haritunians T, Taylor KD, Rotter JI, Ippoliti A, Dubinsky M, Vasiliauskas EA, Melmed GY, Psaty BM, Targan SR, Fleshner P, McGovern DP. 857 Genetic Predictors of Medically Refractive Ulcerative Colitis (UC) Requiring Colectomy Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)60586-2  1
2008 Shih DQ, Targan SR, McGovern D. Recent advances in IBD pathogenesis: genetics and immunobiology. Current Gastroenterology Reports. 10: 568-75. PMID 19006613 DOI: 10.1007/S11894-008-0104-X  1
2008 Shen C, Landers CJ, Derkowski C, Elson CO, Targan SR. Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease. Inflammatory Bowel Diseases. 14: 1641-51. PMID 18825772 DOI: 10.1002/Ibd.20645  1
2008 Melmed GY, Targan SR, Yasothan U, Hanicq D, Kirkpatrick P. Certolizumab pegol. Nature Reviews. Drug Discovery. 7: 641-2. PMID 18670430 DOI: 10.1038/nrd2654  1
2008 Brewer S, McPherson M, Fujiwara D, Turovskaya O, Ziring D, Chen L, Takedatsu H, Targan SR, Wei B, Braun J. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography. Gastroenterology. 135: 744-55. PMID 18639553 DOI: 10.1053/J.Gastro.2008.06.040  1
2008 Dubinsky MC, Kugathasan S, Mei L, Picornell Y, Nebel J, Wrobel I, Quiros A, Silber G, Wahbeh G, Katzir L, Vasiliauskas E, Bahar R, Otley A, Mack D, Evans J, ... ... Targan SR, et al. Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 6: 1105-11. PMID 18619921 DOI: 10.1016/J.Cgh.2008.04.032  1
2008 Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology. 135: 552-67. PMID 18598698 DOI: 10.1053/J.Gastro.2008.04.037  1
2008 Colbert RA, Deodhar AA, Khan MA, Lories RJ, Maksymowych WP, Reveille JD, Ritchlin CT, Rosenbaum JT, Targan SR, Weisman M, Clegg DO. 2007 annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN). The Journal of Rheumatology. 35: 1398-402. PMID 18484685  1
2008 Taylor KD, Targan SR, Mei L, Ippoliti AF, McGovern D, Mengesha E, King L, Rotter JI. IL23R haplotypes provide a large population attributable risk for Crohn's disease. Inflammatory Bowel Diseases. 14: 1185-91. PMID 18470928 DOI: 10.1002/Ibd.20478  1
2008 Fleshner P, Ippoliti A, Dubinsky M, Vasiliauskas E, Mei L, Papadakis KA, Rotter JI, Landers C, Targan S. Both preoperative perinuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients influence pouchitis development after ileal pouch-anal anastomosis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 6: 561-8. PMID 18378498 DOI: 10.1016/J.Cgh.2008.01.002  1
2008 Mitsuhashi M, Targan SR. Ex vivo simulation of IgG Fc and T-cell receptor functions: an application to inflammatory bowel disease. Inflammatory Bowel Diseases. 14: 1061-7. PMID 18340639 DOI: 10.1002/Ibd.20428  1
2008 Shih DQ, Targan SR. Immunopathogenesis of inflammatory bowel disease. World Journal of Gastroenterology. 14: 390-400. PMID 18200661 DOI: 10.3748/Wjg.14.390  1
2008 Mitsuhashi M, Ogura M, Endo K, Obara K, Izutsu H, Targan SR, Maemura M, Tachikawa D, Shinagawa A. Ex vivo induction of mRNA in human whole blood as a new platform of drug and dietary supplement development. Pharmaceutical Research. 25: 1116-24. PMID 18183479 DOI: 10.1007/S11095-007-9510-2  1
2008 Melmed GY, Fleshner PR, Bardakcioglu O, Ippoliti A, Vasiliauskas EA, Papadakis KA, Dubinsky M, Landers C, Rotter JI, Targan SR. Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis. Diseases of the Colon and Rectum. 51: 100-8. PMID 18085333 DOI: 10.1007/S10350-007-9158-3  1
2008 Vandewalle-El Khoury P, Colombel JF, Joossens S, Standaert-Vitse A, Collot M, Halfvarson J, Ayadi A, Landers CJ, Vermeire S, Rutgeerts P, Targan SR, Chamaillard M, Mallet JM, Sendid B, Poulain D. Detection of antisynthetic mannoside antibodies (ASigmaMA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and prediction. The American Journal of Gastroenterology. 103: 949-57. PMID 18047546 DOI: 10.1111/J.1572-0241.2007.01648.X  1
2008 Hardi R, Mayer L, Targan SR, Yellin M, Cardarelli PM, Das KM. 704 A Phase 1 Open-Label, Single-Dose, Dose-Escalation Study of Mdx-1100, a High-Affinity, Neutralizing, Fully Human Igg1κ Anti-CXCL10 (Ip10) Monoclonal Antibody, in Ulcerative Colitis Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)60466-7  1
2008 Targan SR, Karp LC. Designer Drugs: From Bench to Bedside Challenges in Inflammatory Bowel Disease: Second Edition. 221-231. DOI: 10.1002/9780470753170.ch18  1
2007 Plevy S, Salzberg B, Van Assche G, Regueiro M, Hommes D, Sandborn W, Hanauer S, Targan S, Mayer L, Mahadevan U, Frankel M, Lowder J. A phase I study of visilizumab, a humanized anti-CD3 monoclonal antibody, in severe steroid-refractory ulcerative colitis. Gastroenterology. 133: 1414-22. PMID 17920064 DOI: 10.1053/J.Gastro.2007.08.035  1
2007 Schluender SJ, Ippoliti A, Dubinsky M, Vasiliauskas EA, Papadakis KA, Mei L, Targan SR, Fleshner PR. Does infliximab influence surgical morbidity of ileal pouch-anal anastomosis in patients with ulcerative colitis? Diseases of the Colon and Rectum. 50: 1747-53. PMID 17704969 DOI: 10.1007/S10350-007-9008-3  1
2007 Clark M, Colombel JF, Feagan BC, Fedorak RN, Hanauer SB, Kamm MA, Mayer L, Regueiro C, Rutgeerts P, Sandborn WJ, Sands BE, Schreiber S, Targan S, Travis S, Vermeire S. American gastroenterological association consensus development conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006. Gastroenterology. 133: 312-39. PMID 17631151 DOI: 10.1053/J.Gastro.2007.05.006  1
2007 Targan SR, Karp LC. Inflammatory bowel disease diagnosis, evaluation and classification: state-of-the art approach. Current Opinion in Gastroenterology. 23: 390-4. PMID 17545774 DOI: 10.1097/Mog.0B013E3281722271  1
2007 Fleshner P, Ippoliti A, Dubinsky M, Ognibene S, Vasiliauskas E, Chelly M, Mei L, Papadakis KA, Landers C, Targan S. A prospective multivariate analysis of clinical factors associated with pouchitis after ileal pouch-anal anastomosis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 5: 952-8; quiz 887. PMID 17544871 DOI: 10.1016/J.Cgh.2007.03.020  1
2007 Targan SR, Feagan BG, Fedorak RN, Lashner BA, Panaccione R, Present DH, Spehlmann ME, Rutgeerts PJ, Tulassay Z, Volfova M, Wolf DC, Hernandez C, Bornstein J, Sandborn WJ. Natalizumab for the Treatment of Active Crohn's Disease: Results of the ENCORE Trial Gastroenterology. 132: 1672-1683. PMID 17484865 DOI: 10.1053/J.Gastro.2007.03.024  1
2007 Melmed GY, Elashoff R, Chen GC, Nastaskin I, Papadakis KA, Vasiliauskas EA, Liu W, Landers C, Ippoliti AF, Targan SR. Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control study. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 5: 602-8; quiz 525. PMID 17478347 DOI: 10.1016/J.Cgh.2007.02.015  1
2007 Rioux JD, Xavier RJ, Taylor KD, Silverberg MS, Goyette P, Huett A, Green T, Kuballa P, Barmada MM, Datta LW, Shugart YY, Griffiths AM, Targan SR, Ippoliti AF, Bernard EJ, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nature Genetics. 39: 596-604. PMID 17435756 DOI: 10.1038/Ng2032  1
2007 Prehn JL, Thomas LS, Landers CJ, Yu QT, Michelsen KS, Targan SR. The T cell costimulator TL1A is induced by FcγR signaling in human monocytes and dendritic cells Journal of Immunology. 178: 4033-4038. PMID 17371957 DOI: 10.4049/Jimmunol.178.7.4033  1
2007 Saruta M, Yu QT, Avanesyan A, Fleshner PR, Targan SR, Papadakis KA. Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. Journal of Immunology (Baltimore, Md. : 1950). 178: 3293-300. PMID 17312180 DOI: 10.4049/Jimmunol.178.5.3293  1
2007 Dubinsky MC, Wang D, Picornell Y, Wrobel I, Katzir L, Quiros A, Dutridge D, Wahbeh G, Silber G, Bahar R, Mengesha E, Targan SR, Taylor KD, Rotter JI. IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflammatory Bowel Diseases. 13: 511-5. PMID 17309073 DOI: 10.1002/Ibd.20126  1
2007 Papadakis KA, Yang H, Ippoliti A, Mei L, Elson CO, Hershberg RM, Vasiliauskas EA, Fleshner PR, Abreu MT, Taylor K, Landers CJ, Rotter JI, Targan SR. Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associations. Inflammatory Bowel Diseases. 13: 524-30. PMID 17260364 DOI: 10.1002/Ibd.20106  1
2007 Devlin SM, Yang H, Ippoliti A, Taylor KD, Landers CJ, Su X, Abreu MT, Papadakis KA, Vasiliauskas EA, Melmed GY, Fleshner PR, Mei L, Rotter JI, Targan SR. NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives. Gastroenterology. 132: 576-86. PMID 17258734 DOI: 10.1053/J.Gastro.2006.11.013  1
2007 Hommes DW, Targan SR, Dignass A, Baumgart DC, Mayer L, Zhang L, Wilson K, Pearce T. P108 Visilizumab Therapy in Subjects With Moderate-To-Severe, Refractory Crohn's Disease Journal of Crohn's and Colitis Supplements. 1: 31-31. DOI: 10.1016/S1873-9954(07)70120-9  1
2006 Spivak J, Landers CJ, Vasiliauskas EA, Abreu MT, Dubinsky MC, Papadakis KA, Ippoliti A, Targan SR, Fleshner PR. Antibodies to I2 predict clinical response to fecal diversion in Crohn's disease. Inflammatory Bowel Diseases. 12: 1122-30. PMID 17119386 DOI: 10.1097/01.Mib.0000235833.47423.D7  1
2006 Kucharzik T, Maaser C, Lügering A, Kagnoff M, Mayer L, Targan S, Domschke W. Recent understanding of IBD pathogenesis: implications for future therapies. Inflammatory Bowel Diseases. 12: 1068-83. PMID 17075348 DOI: 10.1097/01.Mib.0000235827.21778.D5  1
2006 Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science (New York, N.Y.). 314: 1461-3. PMID 17068223 DOI: 10.1126/Science.1135245  1
2006 Elson CO, Cong Y, Qi F, Hershberg RM, Targan SR. Molecular approaches to the role of the microbiota in inflammatory bowel disease. Annals of the New York Academy of Sciences. 1072: 39-51. PMID 17057189 DOI: 10.1196/Annals.1326.010  1
2006 Vasiliauskas EA, Church JA, Silverman N, Barry M, Targan SR, Dubinsky MC. Case report: evidence for transplacental transfer of maternally administered infliximab to the newborn. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 4: 1255-8. PMID 17045211 DOI: 10.1016/J.Cgh.2006.07.018  1
2006 Melmed GY, Ippoliti AF, Papadakis KA, Tran TT, Birt JL, Lee SK, Frenck RW, Targan SR, Vasiliauskas EA. Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses. The American Journal of Gastroenterology. 101: 1834-40. PMID 16817843 DOI: 10.1111/J.1572-0241.2006.00646.X  1
2006 Gonsky R, Deem RL, Bream JH, Young HA, Targan SR. An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells. Genes and Immunity. 7: 342-51. PMID 16724074 DOI: 10.1038/Sj.Gene.6364305  1
2006 Braun J, Targan SR. Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease. Advances in Experimental Medicine and Biology. 579: 209-18. PMID 16620020 DOI: 10.1007/0-387-33778-4_13  1
2006 Mei L, Targan SR, Landers CJ, Dutridge D, Ippoliti A, Vasiliauskas EA, Papadakis KA, Fleshner PR, Rotter JI, Yang H. Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease. Gastroenterology. 130: 1078-85. PMID 16618402 DOI: 10.1053/J.Gastro.2006.02.013  1
2006 Van Assche G, Sandborn WJ, Feagan BG, Salzberg BA, Silvers D, Monroe PS, Pandak WM, Anderson FH, Valentine JF, Wild GE, Geenen DJ, Sprague R, Targan SR, Rutgeerts P, Vexler V, et al. Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial. Gut. 55: 1568-74. PMID 16603634 DOI: 10.1136/gut.2005.089854  1
2006 Dubinsky MC, Lin YC, Dutridge D, Picornell Y, Landers CJ, Farrior S, Wrobel I, Quiros A, Vasiliauskas EA, Grill B, Israel D, Bahar R, Christie D, Wahbeh G, Silber G, ... ... Targan SR, et al. Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progression. The American Journal of Gastroenterology. 101: 360-7. PMID 16454844 DOI: 10.1111/J.1572-0241.2006.00456.X  1
2006 Abreu MT, Geller JL, Vasiliauskas EA, Kam LY, Vora P, Martyak LA, Yang H, Hu B, Lin YC, Keenan G, Price J, Landers CJ, Adams JS, Targan SR. Treatment with infliximab is associated with increased markers of bone formation in patients with Crohn's disease. Journal of Clinical Gastroenterology. 40: 55-63. PMID 16340635 DOI: 10.1097/01.Mcg.0000190762.80615.D4  1
2005 Sandborn WJ, Colombel JF, Enns R, Feagan BG, Hanauer SB, Lawrance IC, Panaccione R, Sanders M, Schreiber S, Targan S, van Deventer S, Goldblum R, Despain D, Hogge GS, Rutgeerts P, et al. Natalizumab induction and maintenance therapy for Crohn's disease. The New England Journal of Medicine. 353: 1912-25. PMID 16267322 DOI: 10.1056/Nejmoa043335  1
2005 Isaacs KL, Lewis JD, Sandborn WJ, Sands BE, Targan SR, Merrick M. State of the art: IBD therapy and clinical trials in IBD Inflammatory Bowel Diseases. 11. PMID 16254481 DOI: 10.1097/01.Mib.0000184852.84558.B2  1
2005 Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, Caprilli R, Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus EV, Peña AS, Riddell RH, ... ... Targan SR, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. 19: 5A-36A. PMID 16151544 DOI: 10.1155/2005/269076  1
2005 Targan SR, Karp LC. Defects in mucosal immunity leading to ulcerative colitis. Immunological Reviews. 206: 296-305. PMID 16048556 DOI: 10.1111/J.0105-2896.2005.00286.X  1
2005 Targan SR, Landers CJ, Yang H, Lodes MJ, Cong Y, Papadakis KA, Vasiliauskas E, Elson CO, Hershberg RM. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 128: 2020-8. PMID 15940634 DOI: 10.1053/J.Gastro.2005.03.046  1
2005 Hui T, Landers C, Vasiliauskas E, Abreu M, Dubinsky M, Papadakis KA, Price J, Lin YC, Huiying Y, Targan S, Fleshner P. Serologic responses in indeterminate colitis patients before ileal pouch-anal anastomosis may determine those at risk for continuous pouch inflammation. Diseases of the Colon and Rectum. 48: 1254-62. PMID 15868228 DOI: 10.1007/S10350-005-0013-0  1
2005 Papadakis KA, Zhu D, Prehn JL, Landers C, Avanesyan A, Lafkas G, Targan SR. Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 174: 4985-90. PMID 15814728 DOI: 10.4049/Jimmunol.174.8.4985  1
2005 Papadakis KA, Shaye OA, Vasiliauskas EA, Ippoliti A, Dubinsky MC, Birt J, Paavola J, Lee SK, Price J, Targan SR, Abreu MT. Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximab. The American Journal of Gastroenterology. 100: 75-9. PMID 15654784 DOI: 10.1111/J.1572-0241.2005.40647.X  1
2005 Cohavy O, Zhou J, Ware CF, Targan SR. LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling. Journal of Immunology (Baltimore, Md. : 1950). 174: 646-53. PMID 15634882 DOI: 10.4049/Jimmunol.174.2.646  1
2005 Sitaraman SV, Klapproth JM, Moore DA, Landers C, Targan S, Williams IR, Gewirtz AT. Elevated flagellin-specific immunoglobulins in Crohn's disease. American Journal of Physiology. Gastrointestinal and Liver Physiology. 288: G403-6. PMID 15388489 DOI: 10.1152/Ajpgi.00357.2004  1
2005 Karp LC, Targan SR. Ulcerative colitis: Evolving insights into pathogenesis Mucosal Immunology, Two-Volume Set. 1255-1263. DOI: 10.1016/B978-012491543-5/50075-9  1
2004 Papadakis KA, Prehn J, Zhu D, Landers C, Gaiennie J, Fleshner PR, Targan SR. Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa. Inflammatory Bowel Diseases. 10: 778-88. PMID 15626897 DOI: 10.1097/00054725-200411000-00013  1
2004 Arnott IDR, Landers CJ, Nimmo EJ, Drummond HE, Smith BKR, Targan SR, Satsangi J. Sero-reactivity to microbial components in Crohn's disease is associated with disease severity and progression, but not NOD2/CARD15 genotype American Journal of Gastroenterology. 99: 2376-2384. PMID 15571586 DOI: 10.1111/J.1572-0241.2004.40417.X  1
2004 Matuk R, Crawford J, Abreu MT, Targan SR, Vasiliauskas EA, Papadakis KA. The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease. Inflammatory Bowel Diseases. 10: 352-6. PMID 15475742 DOI: 10.1097/00054725-200407000-00005  1
2004 Youdim A, Vasiliauskas EA, Targan SR, Papadakis KA, Ippoliti A, Dubinsky MC, Lechago J, Paavola J, Loane J, Lee SK, Gaiennie J, Smith K, Do J, Abreu MT. A pilot study of adalimumab in infliximab-allergic patients. Inflammatory Bowel Diseases. 10: 333-8. PMID 15475739 DOI: 10.1097/00054725-200407000-00002  1
2004 Mow WS, Landers CJ, Steinhart AH, Feagan BG, Croitoru K, Seidman E, Greenberg GR, Targan SR. High-level serum antibodies to bacterial antigens are associated with antibiotic-induced clinical remission in Crohn's disease: a pilot study. Digestive Diseases and Sciences. 49: 1280-6. PMID 15387358 DOI: 10.1023/B:Ddas.0000037824.66186.E2  1
2004 Geller SA, Dubinsky MC, Poordad FF, Vasiliauskas EA, Cohen AH, Abreu MT, Tran T, Martin P, Vierling JM, Targan SR. Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease. The American Journal of Surgical Pathology. 28: 1204-11. PMID 15316320 DOI: 10.1097/01.Pas.0000128665.12063.97  1
2004 Cohavy O, Zhou J, Granger SW, Ware CF, Targan SR. LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine. Journal of Immunology (Baltimore, Md. : 1950). 173: 251-8. PMID 15210782 DOI: 10.4049/Jimmunol.173.1.251  1
2004 Prehn JL, Mehdizadeh S, Landers CJ, Luo X, Cha SC, Wei P, Targan SR. Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-γ, in mucosal inflammation Clinical Immunology. 112: 66-77. PMID 15207783 DOI: 10.1016/J.Clim.2004.02.007  1
2004 Papadakis KA, Prehn JL, Landers C, Han Q, Luo X, Cha SC, Wei P, Targan SR. TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. Journal of Immunology (Baltimore, Md. : 1950). 172: 7002-7. PMID 15153521 DOI: 10.4049/Jimmunol.172.11.7002  1
2004 Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, Targan SR, Fort M, Hershberg RM. Bacterial flagellin is a dominant antigen in Crohn disease. The Journal of Clinical Investigation. 113: 1296-306. PMID 15124021 DOI: 10.1172/Jci200420295  1
2004 Mow WS, Abreu-Martin MT, Papadakis KA, Pitchon HE, Targan SR, Vasiliauskas EA. High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 2: 309-13. PMID 15067625 DOI: 10.1016/S1542-3565(04)00060-6  1
2004 Mow WS, Lo SK, Targan SR, Dubinsky MC, Treyzon L, Abreu-Martin MT, Papadakis KA, Vasiliauskas EA. Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 2: 31-40. PMID 15017630 DOI: 10.1016/S1542-3565(03)00289-1  1
2004 Mow WS, Vasiliauskas EA, Lin YC, Fleshner PR, Papadakis KA, Taylor KD, Landers CJ, Abreu-Martin MT, Rotter JI, Yang H, Targan SR. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology. 126: 414-24. PMID 14762777 DOI: 10.1053/J.Gastro.2003.11.015  1
2003 Papadakis KA, Treyzon L, Abreu MT, Fleshner PR, Targan SR, Vasiliauskas EA. Infliximab in the treatment of medically refractory indeterminate colitis. Alimentary Pharmacology & Therapeutics. 18: 741-747. PMID 14510748 DOI: 10.1046/J.1365-2036.2003.01739.X  1
2003 Dubinsky MC, Vasiliauskas EA, Singh H, Abreu MT, Papadakis KA, Tran T, Martin P, Vierling JM, Geller SA, Targan SR, Poordad FF. 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology. 125: 298-303. PMID 12891528 DOI: 10.1016/S0016-5085(03)00938-7  1
2003 Papadakis KA, Landers C, Prehn J, Kouroumalis EA, Moreno ST, Gutierrez-Ramos JC, Hodge MR, Targan SR. CC chemokine receptor 9 expression defines a subset of peripheral blood lymphocytes with mucosal T cell phenotype and Th1 or T-regulatory 1 cytokine profile. Journal of Immunology (Baltimore, Md. : 1950). 171: 159-65. PMID 12816994 DOI: 10.4049/Jimmunol.171.1.159  1
2003 Elson CO, Sartor RB, Targan SR, Sandborn WJ. Challenges in IBD Research: updating the scientific agendas. Inflammatory Bowel Diseases. 9: 137-53. PMID 12792219 DOI: 10.1097/00054725-200305000-00001  1
2003 Sugimura K, Taylor KD, Lin YC, Hang T, Wang D, Tang YM, Fischel-Ghodsian N, Targan SR, Rotter JI, Yang H. A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews. American Journal of Human Genetics. 72: 509-18. PMID 12577202 DOI: 10.1086/367848  1
2003 Papadakis KA, Rosenbloom B, Targan SR. Anti-CD2O chimeric monoclonal antibody (rituximab) treatment of immune-mediated thrombocytopenia associated with Crohn's disease. Gastroenterology. 124: 583. PMID 12557172 DOI: 10.1053/Gast.2003.50081  1
2002 Landers CJ, Cohavy O, Misra R, Yang H, Lin YC, Braun J, Targan SR. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology. 123: 689-99. PMID 12198693 DOI: 10.1053/Gast.2002.35379  1
2002 Abreu MT, Taylor KD, Lin YC, Hang T, Gaiennie J, Landers CJ, Vasiliauskas EA, Kam LY, Rojany M, Papadakis KA, Rotter JI, Targan SR, Yang H. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. Gastroenterology. 123: 679-88. PMID 12198692 DOI: 10.1053/gast.2002.35393  1
2001 Prehn JL, Landers C, Muller GW, Man HW, Stirling DI, Targan SR. Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues. Journal of Clinical Immunology. 21: 357-64. PMID 11720008 DOI: 10.1023/A:1012292703871  1
2001 Sandborn WJ, Loftus EV, Colombel JF, Fleming KA, Seibold F, Homburger HA, Sendid B, Chapman RW, Tremaine WJ, Kaul DK, Wallace J, Harmsen WS, Zinsmeister AR, Targan SR. Evaluation of serologic disease markers in a population-based cohort of patients with ulcerative colitis and Crohn's disease. Inflammatory Bowel Diseases. 7: 192-201. PMID 11515844 DOI: 10.1097/00054725-200108000-00003  1
2001 Taylor KD, Plevy SE, Yang H, Landers CJ, Barry MJ, Rotter JI, Targan SR. ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease Gastroenterology. 120: 1347-1355. PMID 11313304 DOI: 10.1053/Gast.2001.23966  1
2001 Sandborn WJ, Feagan BG, Hanauer SB, Present DH, Sutherland LR, Kamm MA, Wolf DC, Baker JP, Hawkey C, Archambault A, Bernstein CN, Novak C, Heath PK, Targan SR. An engineered human antibody to TNF (CDP571) for active Crohn's disease: a randomized double-blind placebo-controlled trial. Gastroenterology. 120: 1330-8. PMID 11313302 DOI: 10.1053/Gast.2001.24042  1
2001 Cornillie F, Shealy D, D'Haens G, Geboes K, Van Assche G, Ceuppens J, Wagner C, Schaible T, Plevy SE, Targan SR, Rutgeerts P. Infliximab induces potent anti-inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease Alimentary Pharmacology and Therapeutics. 15: 463-473. PMID 11284774 DOI: 10.1046/J.1365-2036.2001.00956.X  1
2001 Gangarosa LM, Shanahan F, Talley NJ, Targan S, Winter H. Aga technical review on the evaluation of food allergy in gastrointestinal disorders Gastroenterology. 120: 1026-1040. PMID 11231958 DOI: 10.1053/Gast.2001.23031  1
2001 Gangarosa LM, Shanahan F, Talley NJ, Targan S, Winter H. American gastroenterological association medical position statement: Guidelines for the evaluation of food allergies Gastroenterology. 120: 1023-1025. PMID 11231957 DOI: 10.1053/Gast.2001.23417  1
2000 Rowe FA, Walker JH, Karp LC, Vasiliauskas EA, Plevy SE, Targan SR. Factors predictive of response to cyclosporin treatment for severe, steroid-resistant ulcerative colitis. The American Journal of Gastroenterology. 95: 2000-8. PMID 10950049 DOI: 10.1111/J.1572-0241.2000.02186.X  1
2000 Dubinsky MC, Lamothe S, Yang HY, Targan SR, Sinnett D, Théorêt Y, Seidman EG. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology. 118: 705-13. PMID 10734022 DOI: 10.1016/S0016-5085(00)70140-5  1
2000 Trachtenberg EA, Yang H, Hayes E, Vinson M, Lin C, Targan SR, Tyan D, Erlich H, Rotter JI. HLA Class II Haplotype Associations with Inflammatory Bowel Disease in Jewish (Ashkenazi) and Non-Jewish Caucasian Populations Human Immunology. 61: 326-333. PMID 10689124 DOI: 10.1016/S0198-8859(99)00134-2  1
2000 Eggena M, Cohavy O, Parseghian MH, Hamkalo BA, Clemens D, Targan SR, Gordon LK, Braun J. Identification of histone H1 as a cognate antigen of the ulcerative colitis-associated marker antibody pANCA. Journal of Autoimmunity. 14: 83-97. PMID 10648119 DOI: 10.1006/Jaut.1999.0340  1
2000 Pimentel M, Chang M, Chow EJ, Tabibzadeh S, Kirit-Kiriak V, Targan SR, Lin HC. Original contributionIdentification of a prodromal period in Crohn’s disease but not ulcerative colitis The American Journal of Gastroenterology. 95. DOI: 10.1016/S0002-9270(00)02154-7  0.01
1999 Kam LY, Targan SR. Cytokine-based therapies in inflammatory bowel disease. Current Opinion in Gastroenterology. 15: 302-307. PMID 17023962 DOI: 10.1097/00001574-199907000-00005  1
1999 Vasiliauskas EA, Kam LY, Abreu-Martin MT, Hassard PV, Papadakis KA, Yang H, Zeldis JB, Targan SR. An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease. Gastroenterology. 117: 1278-1287. PMID 10579968 DOI: 10.1016/S0016-5085(99)70277-5  1
1999 Sandborn WJ, Tremaine WJ, Wolf DC, Targan SR, Sninsky CA, Sutherland LR, Hanauer SB, McDonald JWD, Feagan BG, Fedorak RN, Isaacs KL, Pike MG, Mays DC, Lipsky JJ, Gordon S, et al. Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease Gastroenterology. 117: 527-535. PMID 10464128 DOI: 10.1016/S0016-5085(99)70445-2  1
1999 Facklis K, Plevy SE, Vasiliauskas EA, Kam L, Taylor K, Targan SR, Fleshner PR. Crohn's disease-associated genetic marker is seen in medically unresponsive ulcerative colitis patients and may be associated with pouch- specific complications Diseases of the Colon and Rectum. 42: 601-606. PMID 10344681 DOI: 10.1007/Bf02234133  1
1999 Yang H, Plevy SE, Taylor K, Tyan D, Fischel-Ghodsian N, McElree C, Targan SR, Rotter JI. Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses Gut. 44: 519-526. PMID 10075959 DOI: 10.1136/Gut.44.4.519  1
1999 Abreu-Martin MT, Palladino AA, Faris M, Carramanzana NM, Nel AE, Targan SR. Fas activates the JNK pathway in human colonic epithelial cells: lack of a direct role in apoptosis. The American Journal of Physiology. 276: G599-605. PMID 10070035 DOI: 10.1152/Ajpgi.1999.276.3.G599  1
1998 Quinton JF, Sendid B, Reumaux D, Duthilleul P, Cortot A, Grandbastien B, Charrier G, Targan SR, Colombel JF, Poulain D. Anti-Saccharomyces cerevisiae manna antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: Prevalence and diagnostic role Gut. 42: 788-791. PMID 9691915 DOI: 10.1136/Gut.42.6.788  1
1998 Satsangi J, Landers CJ, Welsh KI, Koss K, Targan S, Jewell DP. The presence of anti‐neutrophil antibodies reflects clinical and genetic heterogeneity within inflammatory bowel disease Inflammatory Bowel Diseases. 4: 18-26. PMID 9552224 DOI: 10.1097/00054725-199802000-00004  1
1998 Kaditis AG, Perrault J, Sandborn WJ, Landers CJ, Zinsmeister AR, Targan SR. Antineutrophil cytoplasmic antibody subtypes in children and adolescents after ileal pouch-anal anastomosis for ulcerative colitis. Journal of Pediatric Gastroenterology and Nutrition. 26: 386-92. PMID 9552133 DOI: 10.1097/00005176-199804000-00005  1
1997 Targan SR, Hanauer SB, Deventer SJHv, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ. A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease The New England Journal of Medicine. 337: 1029-1035. PMID 9321530 DOI: 10.1056/Nejm199710093371502  1
1997 Roussomoustakaki M, Satsangi J, Welsh K, Louis E, Fanning G, Targan S, Landers C, Jewell DP. Genetic markers may predict disease behavior in patients with ulcerative colitis. Gastroenterology. 112: 1845-1853. PMID 9178675 DOI: 10.1053/Gast.1997.V112.Pm9178675  1
1996 Vasiliauskas EA, Plevy SE, Landers CJ, Binder SW, Ferguson DM, Yang H, Rotter JI, Vidrich A, Targan SR. Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup. Gastroenterology. 110: 1810-9. PMID 8964407 DOI: 10.1053/Gast.1996.V110.Pm8964407  1
1996 Abreu-Martin MT, Targan SR. Regulation Of Immune Responses Of The Intestinal Mucosa Critical Reviews in Immunology. 16: 277-309. PMID 8922900 DOI: 10.1615/Critrevimmunol.V16.I3.30  1
1996 Ohmen JD, Yang H, Yamamoto KK, Zhao H, Ma Y, Bentley LG, Huang Z, Gerwehr S, Pressman S, McElree C, Targan S, Rotter JI, Fischel-Ghodsian N. Susceptibility Locus for Inflammatory Bowel Disease on Chromosome 16 has a Role in Crohn's disease, but Not in Ulcerative Colitis Human Molecular Genetics. 5: 1679-1683. PMID 8894707 DOI: 10.1093/Hmg/5.10.1679  1
1996 Sandborn WJ, Landers CJ, Tremaine WJ, Targan SR. Association of Antineutrophil Cytoplasmic Antibodies With Resistance to Treatment of Left-Sided Ulcerative Colitis: Results of a Pilot Study Mayo Clinic Proceedings. 71: 431-436. PMID 8628021 DOI: 10.4065/71.5.431  1
1996 Plevy SE, Targan SR, Yang H, Fernandez D, Rotter JI, Toyoda H. Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6 Gastroenterology. 110: 1053-1060. PMID 8612993 DOI: 10.1053/Gast.1996.V110.Pm8612993  1
1996 Plevy SE, Targan SR. ANTI-TUMOR NECROSIS FACTOR-α THERAPY IN CROHN'S DISEASE: A MAGIC BULLET FINALLY HITS ITS MARK. Inflammatory Bowel Diseases. 2: 158-159. DOI: 10.1002/Ibd.3780020216  1
1995 Yang H, Vora DK, Targan SR, Toyoda H, Beaudet AL, Rotter JI. Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease. Gastroenterology. 109: 440-8. PMID 7615193 DOI: 10.1016/0016-5085(95)90331-3  1
1995 Fleshner PR, Michelassi F, Rubin M, Hanauer SB, Plevy SE, Targan SR. Morbidity of subtotal colectomy in patients with severe ulcerative colitis unresponsive to cyclosporin Diseases of the Colon &Amp; Rectum. 38: 1241-1245. PMID 7497833 DOI: 10.1007/Bf02049146  1
1995 Kim WH, Choi PM, Landers CJ, Targan SR. Role of antineutrophil cytoplasmic antibodies in an ethnically distinct population: Korean patients with ulcerative colitis. The American Journal of Gastroenterology. 90: 1953-1958. DOI: 10.1111/J.1572-0241.1995.Tb10169.X  1
1995 Targan SR. New IBD markers: definition of disease heterogeneity Canadian Journal of Gastroenterology & Hepatology. 9: 301-304. DOI: 10.1007/978-94-009-0371-5_22  0.01
1993 Toyoda H, Wang SJ, Yang HY, Redford A, Magalong D, Tyan D, McElree CK, Pressman SR, Shanahan F, Targan SR. Distinct associations of HLA class II genes with inflammatory bowel disease. Gastroenterology. 104: 741-8. PMID 8440433 DOI: 10.1016/0016-5085(93)91009-7  1
1993 Yang H, Rotter JI, Toyoda H, Landers C, Tyran D, McElree CK, Targan SR. Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers. Journal of Clinical Investigation. 92: 1080-1084. PMID 8349790 DOI: 10.1172/Jci116613  1
1992 Shanahan F, Duerr RH, Rotter JI, Yang H, Sutherland LR, McElree C, Landers CJ, Targan SR. Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology. 103: 456-461. PMID 1634063 DOI: 10.1016/0016-5085(92)90834-L  1
1990 Saxon A, Shanahan F, Landers C, Ganz T, Targan S. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease The Journal of Allergy and Clinical Immunology. 86: 202-210. PMID 2200820 DOI: 10.1016/S0091-6749(05)80067-3  1
1989 Randolph LM, Toyoda H, McElree CK, Shanahan F, Targan SR, Rotter JI. Lack of an association between polymorphisms of the T-cell receptor alpha-chain and ulcerative colitis. Gastroenterology. 97: 1115-20. PMID 2571544 DOI: 10.1016/0016-5085(89)91680-6  1
1988 Karp LC, Targan SR. New enema treatments for inflammatory bowel disease. Digestive Diseases and Sciences. 33: 85S-87S. PMID 3278870 DOI: 10.1007/Bf01538136  1
1985 Stevens R, Oliver M, Brogan M, Heiserodt J, Targan S. Defective generation of tetanus-specific antibody-producing B cells after in vivo immunization of Crohn's disease and ulcerative colitis patients. Gastroenterology. 88: 1860-1866. PMID 3873371 DOI: 10.1016/0016-5085(85)90011-3  0.01
1982 Schwartz AG, Targan SR, Saxon A, Weinstein WM. Sulfasalazine-induced exacerbation of ulcerative colitis New England Journal of Medicine. 306: 409-412. PMID 6120459 DOI: 10.1056/Nejm198202183060708  1
1982 Targan SR. Mechanisms Of Nk Activation: Models To Study Induction Of Lysis And Enhancement Of Lytic Efficiency Nk Cells and Other Natural Effector Cells. 995-1002. DOI: 10.1016/B978-0-12-341360-4.50148-7  0.01
1977 Targan SR, Chow AW, Guze LB. Role of anaerobic bacteria in spontaneous peritonitis of cirrhosis: report of two cases and review of the literature. The American Journal of Medicine. 62: 397-403. PMID 190883 DOI: 10.1016/0002-9343(77)90837-3  1
1976 Bayer AS, Targan SR, Pitchon HE, Guze LB. Dilantin toxicity: miliary pulmonary infiltrates and hypoxemia. Annals of Internal Medicine. 85: 475-6. PMID 970776 DOI: 10.7326/0003-4819-85-4-475  1
1976 Targan SR, Chow AW, Gun LB. Spontaneous Peritonitis of Cirrhosis Due to Camipylobacter Fetus Gastroenterology. 71: 311-313. DOI: 10.1016/S0016-5085(76)80210-7  1
1975 Targan SR, Chassin MRG, Guze LB. Dilantin®-Induced Disseminated Intravascular Coagulation with Purpura Fulminans: A Case Report Annals of Internal Medicine. 83: 227-230. PMID 1147459 DOI: 10.7326/0003-4819-83-2-227  1
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