| Year |
Citation |
Score |
| 2024 |
Dunkelmann DL, Piedrafita C, Dickson A, Liu KC, Elliott TS, Fiedler M, Bellini D, Zhou A, Cervettini D, Chin JW. Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism. Nature. PMID 38200312 DOI: 10.1038/s41586-023-06897-6 |
0.325 |
|
| 2023 |
Zürcher JF, Kleefeldt AA, Funke LFH, Birnbaum J, Fredens J, Grazioli S, Liu KC, Spinck M, Petris G, Murat P, Rehm FBH, Sale JE, Chin JW. Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly. Nature. PMID 37380776 DOI: 10.1038/s41586-023-06268-1 |
0.778 |
|
| 2023 |
Kehrloesser S, Cast O, Elliott TS, Ernst RJ, Machel AC, Chen JX, Chin JW, Miller ML. Cell-of-origin-specific proteomics of extracellular vesicles. Pnas Nexus. 2: pgad107. PMID 37091541 DOI: 10.1093/pnasnexus/pgad107 |
0.805 |
|
| 2022 |
Spinck M, Piedrafita C, Robertson WE, Elliott TS, Cervettini D, de la Torre D, Chin JW. Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles. Nature Chemistry. PMID 36550233 DOI: 10.1038/s41557-022-01082-0 |
0.302 |
|
| 2021 |
Davis L, Radman I, Goutou A, Tynan A, Baxter K, Xi Z, O'Shea JM, Chin JW, Greiss S. Precise optical control of gene expression in using improved genetic code expansion and Cre recombinase. Elife. 10. PMID 34350826 DOI: 10.7554/eLife.67075 |
0.78 |
|
| 2021 |
Robertson WE, Funke LFH, de la Torre D, Fredens J, Elliott TS, Spinck M, Christova Y, Cervettini D, Böge FL, Liu KC, Buse S, Maslen S, Salmond GPC, Chin JW. Sense codon reassignment enables viral resistance and encoded polymer synthesis. Science (New York, N.Y.). 372: 1057-1062. PMID 34083482 DOI: 10.1126/science.abg3029 |
0.819 |
|
| 2021 |
Robertson WE, Funke LFH, de la Torre D, Fredens J, Wang K, Chin JW. Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS. Nature Protocols. PMID 33903757 DOI: 10.1038/s41596-020-00464-3 |
0.776 |
|
| 2021 |
Morgan CW, Dale IL, Thomas AP, Hunt J, Chin JW. Selective CRAF Inhibition Elicits Transactivation. Journal of the American Chemical Society. PMID 33750116 DOI: 10.1021/jacs.0c11958 |
0.704 |
|
| 2021 |
Watson JL, Aich S, Oller-Salvia B, Drabek AA, Blacklow SC, Chin J, Derivery E. High-efficacy subcellular micropatterning of proteins using fibrinogen anchors. The Journal of Cell Biology. 220. PMID 33416860 DOI: 10.1083/jcb.202009063 |
0.301 |
|
| 2020 |
de la Torre D, Chin JW. Reprogramming the genetic code. Nature Reviews. Genetics. PMID 33318706 DOI: 10.1038/s41576-020-00307-7 |
0.372 |
|
| 2020 |
Dunkelmann DL, Willis JCW, Beattie AT, Chin JW. Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids. Nature Chemistry. PMID 32472101 DOI: 10.1038/S41557-020-0472-X |
0.821 |
|
| 2020 |
Cervettini D, Tang S, Fried SD, Willis JCW, Funke LFH, Colwell LJ, Chin JW. Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase-tRNA pairs. Nature Biotechnology. PMID 32284585 DOI: 10.1038/S41587-020-0479-2 |
0.83 |
|
| 2019 |
Wang K, de la Torre D, Robertson WE, Chin JW. Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly. Science (New York, N.Y.). 365: 922-926. PMID 31467221 DOI: 10.1126/Science.Aay0737 |
0.669 |
|
| 2019 |
Oller-Salvia B, Chin JW. Efficient phage display with multiple distinct non-canonical amino acids via orthogonal ribosome mediated genetic code expansion. Angewandte Chemie (International Ed. in English). PMID 31157495 DOI: 10.1002/Anie.201902658 |
0.507 |
|
| 2019 |
Fredens J, Wang K, de la Torre D, Funke LFH, Robertson WE, Christova Y, Chia T, Schmied WH, Dunkelmann DL, Beránek V, Uttamapinant C, Llamazares AG, Elliott TS, Chin JW. Total synthesis of Escherichia coli with a recoded genome. Nature. PMID 31092918 DOI: 10.1038/S41586-019-1192-5 |
0.789 |
|
| 2019 |
Fried SD, Elliott TS, Wagner M, Carell T, Chin JW. The Genetic Code is Read by an Idiosyncratic and Highly-Connected Decoding Network Biophysical Journal. 116: 360a-361a. DOI: 10.1016/J.Bpj.2018.11.1963 |
0.765 |
|
| 2018 |
Huguenin-Dezot N, Alonzo DA, Heberlig GW, Mahesh M, Nguyen DP, Dornan MH, Boddy CN, Schmeing TM, Chin JW. Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid. Nature. PMID 30542153 DOI: 10.1038/S41586-018-0781-Z |
0.343 |
|
| 2018 |
Schmied WH, Tnimov Z, Uttamapinant C, Rae CD, Fried SD, Chin JW. Controlling orthogonal ribosome subunit interactions enables evolution of new function. Nature. PMID 30518861 DOI: 10.1038/S41586-018-0773-Z |
0.799 |
|
| 2018 |
Maywood ES, Elliott TS, Patton AP, Krogager TP, Chesham JE, Ernst RJ, Beránek V, Brancaccio M, Chin JW, Hastings MH. Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 30487216 DOI: 10.1073/Pnas.1811438115 |
0.79 |
|
| 2018 |
Uttamapinant C, Howe JD, Lang K, Beránek V, Davis L, Mahesh M, Barry NP, Chin JW. Correction to "Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins". Journal of the American Chemical Society. PMID 30351131 DOI: 10.1021/Jacs.8B10479 |
0.82 |
|
| 2018 |
Beránek V, Willis JCW, Chin JW. An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA Pair Is Highly Active and Orthogonal in Mammalian Cells. Biochemistry. PMID 30260626 DOI: 10.1021/Acs.Biochem.8B00808 |
0.82 |
|
| 2018 |
Baumdick M, Gelléri M, Uttamapinant C, Beránek V, Chin JW, Bastiaens PIH. A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation. Nature Communications. 9: 3847. PMID 30242154 DOI: 10.1038/S41467-018-06299-7 |
0.73 |
|
| 2018 |
Marmelstein AM, Morgan JAM, Penkert M, Rogerson DT, Chin JW, Krause E, Fiedler D. Pyrophosphorylation selective phosphoprotein derivatization. Chemical Science. 9: 5929-5936. PMID 30079207 DOI: 10.1039/C8Sc01233D |
0.417 |
|
| 2018 |
Beránek V, Reinkemeier CD, Zhang MS, Liang AD, Kym G, Chin JW. Genetically Encoded Protein Phosphorylation in Mammalian Cells. Cell Chemical Biology. PMID 29937407 DOI: 10.1016/J.Chembiol.2018.05.013 |
0.824 |
|
| 2018 |
Willis JCW, Chin JW. Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs. Nature Chemistry. PMID 29807989 DOI: 10.1038/S41557-018-0052-5 |
0.819 |
|
| 2018 |
Ranasinghe RT, Challand MR, Ganzinger KA, Lewis BW, Softley C, Schmied WH, Horrocks MH, Shivji N, Chin JW, Spencer J, Klenerman D. Detecting RNA base methylations in single cells by in situ hybridization. Nature Communications. 9: 655. PMID 29440632 DOI: 10.1038/S41467-017-02714-7 |
0.754 |
|
| 2018 |
Oller-Salvia B, Kym G, Chin JW. Rapid and efficient generation of stable antibody-drug conjugates via an encoded cyclopropene and an inverse electron demand Diels-Alder reaction. Angewandte Chemie (International Ed. in English). PMID 29356244 DOI: 10.1002/Anie.201712370 |
0.352 |
|
| 2018 |
Liu CC, Jewett MC, Chin JW, Voigt CA. Toward an orthogonal central dogma. Nature Chemical Biology. 14: 103-106. PMID 29337969 DOI: 10.1038/Nchembio.2554 |
0.385 |
|
| 2017 |
Krogager TP, Ernst RJ, Elliott TS, Calo L, Beránek V, Ciabatti E, Spillantini MG, Tripodi M, Hastings MH, Chin JW. Labeling and identifying cell-specific proteomes in the mouse brain. Nature Biotechnology. PMID 29251727 DOI: 10.1038/Nbt.4056 |
0.794 |
|
| 2017 |
Liaunardy-Jopeace A, Murton BL, Mahesh M, Chin JW, James JR. Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells. Nature Structural & Molecular Biology. PMID 29083415 DOI: 10.1038/Nsmb.3492 |
0.327 |
|
| 2017 |
Chin JW. Expanding and reprogramming the genetic code. Nature. 550: 53-60. PMID 28980641 DOI: 10.1038/Nature24031 |
0.439 |
|
| 2017 |
Kwan TT, Boutureira O, Frye EC, Walsh SJ, Gupta MK, Wallace S, Wu Y, Zhang F, Sore HF, Galloway WRJD, Chin JW, Welch M, Bernardes GJL, Spring DR. Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst. Chemical Science. 8: 3871-3878. PMID 28966779 DOI: 10.1039/C6Sc05313K |
0.54 |
|
| 2017 |
Lambert WD, Scinto SL, Dmitrenko O, Boyd SJ, Magboo R, Mehl RA, Chin JW, Fox JM, Wallace S. Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling. Organic & Biomolecular Chemistry. PMID 28848969 DOI: 10.1039/C7Ob90144E |
0.663 |
|
| 2017 |
Lambert WD, Scinto SL, Dmitrenko O, Boyd SJ, Magboo R, Mehl RA, Chin JW, Fox JM, Wallace S. Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling. Organic & Biomolecular Chemistry. PMID 28752889 DOI: 10.1039/C7Ob01707C |
0.703 |
|
| 2017 |
Gramespacher JA, Stevens AJ, Nguyen DP, Chin JW, Muir TW. Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis. Journal of the American Chemical Society. PMID 28562027 DOI: 10.1021/Jacs.7B02618 |
0.325 |
|
| 2017 |
Zhang MS, Brunner SF, Huguenin-Dezot N, Liang AD, Schmied WH, Rogerson DT, Chin JW. Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing. Nature Methods. PMID 28553966 DOI: 10.1038/Nmeth.4302 |
0.819 |
|
| 2017 |
Perdios L, Lowe AR, Saladino G, Bunney TD, Thiyagarajan N, Alexandrov Y, Dunsby C, French PM, Chin JW, Gervasio FL, Tate EW, Katan M. Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET. Scientific Reports. 7: 39841. PMID 28045057 DOI: 10.1038/Srep39841 |
0.338 |
|
| 2017 |
Zhang MS, Brunner S, Huguenin-Dezot N, Liang AD, Schmied W, Rogerson D, Chin J. Parallel positive selections, deep sequencing and analysis for reprogramming aminoacyl-tRNA synthetase specificity Protocol Exchange. DOI: 10.1038/Protex.2017.046 |
0.752 |
|
| 2016 |
Wang K, Fredens J, Brunner SF, Kim SH, Chia T, Chin JW. Defining synonymous codon compression schemes by genome recoding. Nature. PMID 27776354 DOI: 10.1038/Nature20124 |
0.775 |
|
| 2016 |
Ernst RJ, Krogager TP, Maywood ES, Zanchi R, Beránek V, Elliott TS, Barry NP, Hastings MH, Chin JW. Genetic code expansion in the mouse brain. Nature Chemical Biology. PMID 27571478 DOI: 10.1038/Nchembio.2160 |
0.812 |
|
| 2016 |
Elliott TS, Bianco A, Townsley FM, Fried SD, Chin JW. Tagging and Enriching Proteins Enables Cell-Specific Proteomics. Cell Chemical Biology. 23: 805-15. PMID 27447048 DOI: 10.1016/J.Chembiol.2016.05.018 |
0.825 |
|
| 2016 |
Huguenin-Dezot N, De Cesare V, Peltier J, Knebel A, Kristaryianto YA, Rogerson DT, Kulathu Y, Trost M, Chin JW. Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity. Cell Reports. PMID 27425610 DOI: 10.1016/J.Celrep.2016.06.064 |
0.36 |
|
| 2016 |
Luo J, Arbely E, Zhang J, Chou C, Uprety R, Chin JW, Deiters A. Genetically encoded optical activation of DNA recombination in human cells. Chemical Communications (Cambridge, England). PMID 27277957 DOI: 10.1039/C6Cc03934K |
0.779 |
|
| 2016 |
Walker OS, Elsässer SJ, Mahesh M, Bachman M, Balasubramanian S, Chin JW. Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes. Journal of the American Chemical Society. PMID 26761588 DOI: 10.1021/Jacs.5B07627 |
0.354 |
|
| 2016 |
Elsässer SJ, Ernst RJ, Walker OS, Chin JW. Genetic code expansion in stable cell lines enables encoded chromatin modification. Nature Methods. PMID 26727110 DOI: 10.1038/Nmeth.3701 |
0.835 |
|
| 2015 |
Fried SD, Schmied WH, Uttamapinant C, Chin JW. Ribosome Subunit Stapling for Orthogonal Translation in E. coli. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 127: 12982-12985. PMID 27570300 DOI: 10.1002/ange.201506311 |
0.798 |
|
| 2015 |
Kuhlmann N, Wroblowski S, Knyphausen P, de Boor S, Brenig J, Zienert AY, Meyer-Teschendorf K, Praefcke GJ, Nolte H, Krüger M, Schacherl M, Baumann U, James LC, Chin JW, Lammers M. Structural and mechanistic insights into the regulation of the fundamental Rho-regulator RhoGDIα by lysine acetylation. The Journal of Biological Chemistry. PMID 26719334 DOI: 10.1074/Jbc.M115.707091 |
0.77 |
|
| 2015 |
Fried SD, Schmied WH, Uttamapinant C, Chin JW. Ribosome Subunit Stapling for Orthogonal Translation in E. coli. Angewandte Chemie (International Ed. in English). 54: 12791-4. PMID 26465656 DOI: 10.1002/Anie.201506311 |
0.797 |
|
| 2015 |
Tsai YH, Essig S, James JR, Lang K, Chin JW. Selective, rapid and optically switchable regulation of protein function in live mammalian cells. Nature Chemistry. 7: 554-61. PMID 26100803 DOI: 10.1038/Nchem.2253 |
0.795 |
|
| 2015 |
Rogerson DT, Sachdeva A, Wang K, Haq T, Kazlauskaite A, Hancock SM, Huguenin-Dezot N, Muqit MM, Fry AM, Bayliss R, Chin JW. Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog. Nature Chemical Biology. 11: 496-503. PMID 26030730 DOI: 10.1038/Nchembio.1823 |
0.799 |
|
| 2015 |
Machida T, Lang K, Xue L, Chin JW, Winssinger N. Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne. Bioconjugate Chemistry. 26: 802-6. PMID 25897481 DOI: 10.1021/Acs.Bioconjchem.5B00101 |
0.765 |
|
| 2015 |
Uttamapinant C, Howe JD, Lang K, Beránek V, Davis L, Mahesh M, Barry NP, Chin JW. Genetic code expansion enables live-cell and super-resolution imaging of site-specifically labeled cellular proteins. Journal of the American Chemical Society. 137: 4602-5. PMID 25831022 DOI: 10.1021/Ja512838Z |
0.821 |
|
| 2015 |
Lang K, Davis L, Chin JW. Genetic encoding of unnatural amino acids for labeling proteins. Methods in Molecular Biology (Clifton, N.J.). 1266: 217-28. PMID 25560078 DOI: 10.1007/978-1-4939-2272-7_15 |
0.729 |
|
| 2015 |
Bett JS, Ritorto MS, Ewan R, Jaffray EG, Virdee S, Chin JW, Knebel A, Kurz T, Trost M, Tatham MH, Hay RT. Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers. The Biochemical Journal. 466: 489-98. PMID 25489924 DOI: 10.1042/Bj20141349 |
0.74 |
|
| 2015 |
Fried SD, Schmied WH, Uttamapinant C, Chin JW. Ribosome Subunit Stapling for Orthogonal Translation in E. coli Angewandte Chemie - International Edition. DOI: 10.1002/anie.201506311 |
0.777 |
|
| 2014 |
Darko A, Wallace S, Dmitrenko O, Machovina MM, Mehl RA, Chin JW, Fox JM. Conformationally Strained trans-Cyclooctene with Improved Stability and Excellent Reactivity in Tetrazine Ligation. Chemical Science. 5: 3770-3776. PMID 26113970 DOI: 10.1039/C4Sc01348D |
0.685 |
|
| 2014 |
Wallace S, Chin JW. Strain-promoted sydnone bicyclo-[6.1.0]-nonyne cycloaddition†Electronic supplementary information (ESI) available: Full experimental details, (1)H/(13)C NMR spectral data, protein synthesis and purification. See DOI: 10.1039/c3sc53332h. Chemical Science. 5: 1742-1744. PMID 25580211 DOI: 10.1039/C3Sc53332H |
0.554 |
|
| 2014 |
Schmied WH, Elsässer SJ, Uttamapinant C, Chin JW. Efficient multisite unnatural amino acid incorporation in mammalian cells via optimized pyrrolysyl tRNA synthetase/tRNA expression and engineered eRF1. Journal of the American Chemical Society. 136: 15577-83. PMID 25350841 DOI: 10.1021/Ja5069728 |
0.817 |
|
| 2014 |
Luo J, Uprety R, Naro Y, Chou C, Nguyen DP, Chin JW, Deiters A. Genetically encoded optochemical probes for simultaneous fluorescence reporting and light activation of protein function with two-photon excitation. Journal of the American Chemical Society. 136: 15551-8. PMID 25341086 DOI: 10.1021/Ja5055862 |
0.629 |
|
| 2014 |
Elliott TS, Bianco A, Chin JW. Genetic code expansion and bioorthogonal labelling enables cell specific proteomics in an animal. Current Opinion in Chemical Biology. 21: 154-60. PMID 25159020 DOI: 10.1016/J.Cbpa.2014.07.001 |
0.728 |
|
| 2014 |
Sachdeva A, Wang K, Elliott T, Chin JW. Concerted, rapid, quantitative, and site-specific dual labeling of proteins. Journal of the American Chemical Society. 136: 7785-8. PMID 24857040 DOI: 10.1021/Ja4129789 |
0.823 |
|
| 2014 |
Wang K, Sachdeva A, Cox DJ, Wilf NM, Wilf NW, Lang K, Wallace S, Mehl RA, Chin JW. Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET. Nature Chemistry. 6: 393-403. PMID 24755590 DOI: 10.1038/Nchem.1919 |
0.833 |
|
| 2014 |
Elliott TS, Townsley FM, Bianco A, Ernst RJ, Sachdeva A, Elsässer SJ, Davis L, Lang K, Pisa R, Greiss S, Lilley KS, Chin JW. Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal. Nature Biotechnology. 32: 465-72. PMID 24727715 DOI: 10.1038/Nbt.2860 |
0.794 |
|
| 2014 |
Lang K, Chin JW. Cellular incorporation of unnatural amino acids and bioorthogonal labeling of proteins. Chemical Reviews. 114: 4764-806. PMID 24655057 DOI: 10.1021/Cr400355W |
0.684 |
|
| 2014 |
Chin JW. Expanding and reprogramming the genetic code of cells and animals. Annual Review of Biochemistry. 83: 379-408. PMID 24555827 DOI: 10.1146/Annurev-Biochem-060713-035737 |
0.481 |
|
| 2014 |
Nguyen DP, Mahesh M, Elsässer SJ, Hancock SM, Uttamapinant C, Chin JW. Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells. Journal of the American Chemical Society. 136: 2240-3. PMID 24479649 DOI: 10.1021/Ja412191M |
0.433 |
|
| 2014 |
Lang K, Chin JW. Bioorthogonal reactions for labeling proteins. Acs Chemical Biology. 9: 16-20. PMID 24432752 DOI: 10.1021/Cb4009292 |
0.665 |
|
| 2014 |
Price A, Jacques D, Essig S, Elliott T, Halambage U, Chin J, Aiken C, James L. HIV-1 capsid binds host cofactors to mediate nuclear import Acta Crystallographica Section a Foundations and Advances. 70: C120-C120. DOI: 10.1107/S2053273314098799 |
0.593 |
|
| 2014 |
Wang K, Sachdeva A, Cox DJ, Wilf NM, Lang K, Wallace S, Mehl RA, Chin JW. Erratum: Corrigendum: Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double-labelling and FRET Nature Chemistry. 7: 178-178. DOI: 10.1038/Nchem.2175 |
0.778 |
|
| 2013 |
Radman I, Greiss S, Chin JW. Efficient and rapid C. elegans transgenesis by bombardment and hygromycin B selection. Plos One. 8: e76019. PMID 24130756 DOI: 10.1371/Journal.Pone.0076019 |
0.762 |
|
| 2013 |
Hemphill J, Chou C, Chin JW, Deiters A. Genetically encoded light-activated transcription for spatiotemporal control of gene expression and gene silencing in mammalian cells. Journal of the American Chemical Society. 135: 13433-9. PMID 23931657 DOI: 10.1021/Ja4051026 |
0.594 |
|
| 2013 |
Lang K, Chin JW. Fluorescent imaging: Shining a light into live cells. Nature Chemistry. 5: 81-2. PMID 23344440 DOI: 10.1038/Nchem.1555 |
0.618 |
|
| 2012 |
Elsässer SJ, Huang H, Lewis PW, Chin JW, Allis CD, Patel DJ. DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition. Nature. 491: 560-5. PMID 23075851 DOI: 10.1038/Nature11608 |
0.47 |
|
| 2012 |
Price AJ, Fletcher AJ, Schaller T, Elliott T, Lee K, KewalRamani VN, Chin JW, Towers GJ, James LC. CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. Plos Pathogens. 8: e1002896. PMID 22956906 DOI: 10.1371/Journal.Ppat.1002896 |
0.63 |
|
| 2012 |
Bianco A, Townsley FM, Greiss S, Lang K, Chin JW. Expanding the genetic code of Drosophila melanogaster. Nature Chemical Biology. 8: 748-50. PMID 22864544 DOI: 10.1038/Nchembio.1043 |
0.82 |
|
| 2012 |
Arbely E, Torres-Kolbus J, Deiters A, Chin JW. Photocontrol of tyrosine phosphorylation in mammalian cells via genetic encoding of photocaged tyrosine. Journal of the American Chemical Society. 134: 11912-5. PMID 22758385 DOI: 10.1021/Ja3046958 |
0.787 |
|
| 2012 |
Lang K, Davis L, Wallace S, Mahesh M, Cox DJ, Blackman ML, Fox JM, Chin JW. Genetic Encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions. Journal of the American Chemical Society. 134: 10317-20. PMID 22694658 DOI: 10.1021/Ja302832G |
0.768 |
|
| 2012 |
Chin JW. Molecular biology. Reprogramming the genetic code. Science (New York, N.Y.). 336: 428-9. PMID 22539711 DOI: 10.1126/Science.1221761 |
0.51 |
|
| 2012 |
Lang K, Davis L, Torres-Kolbus J, Chou C, Deiters A, Chin JW. Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction. Nature Chemistry. 4: 298-304. PMID 22437715 DOI: 10.1038/Nchem.1250 |
0.778 |
|
| 2012 |
Davis L, Chin JW. Designer proteins: applications of genetic code expansion in cell biology. Nature Reviews. Molecular Cell Biology. 13: 168-82. PMID 22334143 DOI: 10.1038/Nrm3286 |
0.516 |
|
| 2012 |
Wang K, Schmied WH, Chin JW. Reprogramming the genetic code: from triplet to quadruplet codes. Angewandte Chemie (International Ed. in English). 51: 2288-97. PMID 22262408 DOI: 10.1002/Anie.201105016 |
0.83 |
|
| 2012 |
Licchesi JD, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, El Oualid F, Chin JW, Ovaa H, Bienz M, Komander D. An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. Nature Structural & Molecular Biology. 19: 62-71. PMID 22157957 DOI: 10.1038/Nsmb.2169 |
0.719 |
|
| 2012 |
Wang K, Schmied WH, Chin JW. Die Umprogrammierung des genetischen Codes: vom Triplett- zum Quadruplettcode Angewandte Chemie. 124: 2334-2344. DOI: 10.1002/Ange.201105016 |
0.697 |
|
| 2011 |
Greiss S, Chin JW. Expanding the genetic code of an animal. Journal of the American Chemical Society. 133: 14196-9. PMID 21819153 DOI: 10.1021/Ja2054034 |
0.812 |
|
| 2011 |
Nguyen DP, Elliott T, Holt M, Muir TW, Chin JW. Genetically encoded 1,2-aminothiols facilitate rapid and site-specific protein labeling via a bio-orthogonal cyanobenzothiazole condensation. Journal of the American Chemical Society. 133: 11418-21. PMID 21736333 DOI: 10.1021/Ja203111C |
0.685 |
|
| 2011 |
Virdee S, Kapadnis PB, Elliott T, Lang K, Madrzak J, Nguyen DP, Riechmann L, Chin JW. Traceless and site-specific ubiquitination of recombinant proteins. Journal of the American Chemical Society. 133: 10708-11. PMID 21710965 DOI: 10.1021/Ja202799R |
0.828 |
|
| 2011 |
Oppikofer M, Kueng S, Martino F, Soeroes S, Hancock SM, Chin JW, Fischle W, Gasser SM. A dual role of H4K16 acetylation in the establishment of yeast silent chromatin. The Embo Journal. 30: 2610-21. PMID 21666601 DOI: 10.1038/Emboj.2011.170 |
0.321 |
|
| 2011 |
Chin JW. Reprogramming the genetic code. The Embo Journal. 30: 2312-24. PMID 21602790 DOI: 10.1038/Emboj.2011.160 |
0.401 |
|
| 2011 |
Arbely E, Natan E, Brandt T, Allen MD, Veprintsev DB, Robinson CV, Chin JW, Joerger AC, Fersht AR. Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration. Proceedings of the National Academy of Sciences of the United States of America. 108: 8251-6. PMID 21525412 DOI: 10.1073/Pnas.1105028108 |
0.686 |
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| 2011 |
Gautier A, Deiters A, Chin JW. Light-activated kinases enable temporal dissection of signaling networks in living cells. Journal of the American Chemical Society. 133: 2124-7. PMID 21271704 DOI: 10.1021/Ja1109979 |
0.671 |
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| 2011 |
Akutsu M, Ye Y, Virdee S, Chin JW, Komander D. Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains. Proceedings of the National Academy of Sciences of the United States of America. 108: 2228-33. PMID 21266548 DOI: 10.1073/Pnas.1015287108 |
0.731 |
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| 2011 |
Chou C, Uprety R, Davis L, Chin JW, Deiters A. Genetically encoding an aliphatic diazirine for protein photocrosslinking Chemical Science. 2: 480-483. DOI: 10.1039/C0Sc00373E |
0.67 |
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| 2010 |
Nguyen DP, Garcia Alai MM, Virdee S, Chin JW. Genetically directing É›-N, N-dimethyl-L-lysine in recombinant histones. Chemistry & Biology. 17: 1072-6. PMID 21035729 DOI: 10.1016/J.Chembiol.2010.07.013 |
0.754 |
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| 2010 |
Hancock SM, Uprety R, Deiters A, Chin JW. Expanding the genetic code of yeast for incorporation of diverse unnatural amino acids via a pyrrolysyl-tRNA synthetase/tRNA pair. Journal of the American Chemical Society. 132: 14819-24. PMID 20925334 DOI: 10.1021/Ja104609M |
0.657 |
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| 2010 |
Virdee S, Ye Y, Nguyen DP, Komander D, Chin JW. Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase. Nature Chemical Biology. 6: 750-7. PMID 20802491 DOI: 10.1038/Nchembio.426 |
0.748 |
|
| 2010 |
Lammers M, Neumann H, Chin JW, James LC. Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. Nature Chemical Biology. 6: 331-7. PMID 20364129 DOI: 10.1038/Nchembio.342 |
0.769 |
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| 2010 |
Gautier A, Nguyen DP, Lusic H, An W, Deiters A, Chin JW. Genetically encoded photocontrol of protein localization in mammalian cells. Journal of the American Chemical Society. 132: 4086-8. PMID 20218600 DOI: 10.1021/Ja910688S |
0.766 |
|
| 2010 |
Barrett OP, Chin JW. Evolved orthogonal ribosome purification for in vitro characterization. Nucleic Acids Research. 38: 2682-91. PMID 20185573 DOI: 10.1093/Nar/Gkq120 |
0.349 |
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| 2010 |
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, ... ... Chin J, et al. Regulation of cellular metabolism by protein lysine acetylation. Science (New York, N.Y.). 327: 1000-4. PMID 20167786 DOI: 10.1126/Science.1179689 |
0.323 |
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| 2010 |
Neumann H, Wang K, Davis L, Garcia-Alai M, Chin JW. Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature. 464: 441-4. PMID 20154731 DOI: 10.1038/Nature08817 |
0.825 |
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| 2010 |
Neumann H, Slusarczyk AL, Chin JW. De novo generation of mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs. Journal of the American Chemical Society. 132: 2142-4. PMID 20121121 DOI: 10.1021/Ja9068722 |
0.727 |
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| 2010 |
Virdee S, Ye Y, Nguyen DP, Komander D, Chin JW. Engineered Diubiquitin Synthesis Reveals K29-Isopeptide Specificity of an Otu Deubiquitinase Nature Chemical Biology. 6: 750-757. DOI: 10.2210/Pdb2Xk5/Pdb |
0.69 |
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| 2010 |
Buning R, Koopmans W, Neumann H, Chin J, van Noort J. Regulation of Nucleosome Conformational Dynamics by Post-Translational Histone Modifications Studied with Single-Pair FRET Biophysical Journal. 98: 475a. DOI: 10.1016/J.Bpj.2009.12.2590 |
0.631 |
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| 2009 |
Neumann H, Hancock SM, Buning R, Routh A, Chapman L, Somers J, Owen-Hughes T, van Noort J, Rhodes D, Chin JW. A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Molecular Cell. 36: 153-63. PMID 19818718 DOI: 10.1016/J.Molcel.2009.07.027 |
0.63 |
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| 2009 |
Nguyen DP, Garcia Alai MM, Kapadnis PB, Neumann H, Chin JW. Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones. Journal of the American Chemical Society. 131: 14194-5. PMID 19772323 DOI: 10.1021/Ja906603S |
0.636 |
|
| 2009 |
Nguyen DP, Lusic H, Neumann H, Kapadnis PB, Deiters A, Chin JW. Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. Journal of the American Chemical Society. 131: 8720-1. PMID 19514718 DOI: 10.1021/Ja900553W |
0.778 |
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| 2009 |
An W, Chin JW. Synthesis of orthogonal transcription-translation networks. Proceedings of the National Academy of Sciences of the United States of America. 106: 8477-82. PMID 19443689 DOI: 10.1073/Pnas.0900267106 |
0.317 |
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| 2009 |
Chin JW. Journal club. A molecular biologist gets excited about making designer proteins in cells. Nature. 457: 239. PMID 19148056 DOI: 10.1038/457239E |
0.341 |
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| 2009 |
Buning R, Koopmans WJ, Neumann H, Chin JW, Schmidt T, van Noort J. Effect of Histone Acetylation on Nucleosome Dynamics Revealed by spFRET Microscopy Biophysical Journal. 96: 55a. DOI: 10.1016/J.Bpj.2008.12.179 |
0.619 |
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| 2008 |
Neumann H, Hazen JL, Weinstein J, Mehl RA, Chin JW. Genetically encoding protein oxidative damage. Journal of the American Chemical Society. 130: 4028-33. PMID 18321101 DOI: 10.1021/Ja710100D |
0.771 |
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| 2008 |
Neumann H, Peak-Chew SY, Chin JW. Genetically encoding N(epsilon)-acetyllysine in recombinant proteins. Nature Chemical Biology. 4: 232-4. PMID 18278036 DOI: 10.1038/Nchembio.73 |
0.688 |
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| 2007 |
Cropp TA, Anderson JC, Chin JW. Reprogramming the amino-acid substrate specificity of orthogonal aminoacyl-tRNA synthetases to expand the genetic code of eukaryotic cells. Nature Protocols. 2: 2590-600. PMID 17948002 DOI: 10.1038/Nprot.2007.378 |
0.653 |
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| 2007 |
Wang K, Neumann H, Peak-Chew SY, Chin JW. Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion. Nature Biotechnology. 25: 770-7. PMID 17592474 DOI: 10.1038/Nbt1314 |
0.817 |
|
| 2007 |
Chin JW, Kohler JJ. Current and future prospects in biopolymer chemistry Current Opinion in Chemical Biology. 11: 626-627. DOI: 10.1016/J.Cbpa.2007.10.013 |
0.498 |
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| 2006 |
Cropp TA, Chin JW. Expanding nucleic acid function in vitro and in vivo. Current Opinion in Chemical Biology. 10: 601-6. PMID 17055771 DOI: 10.1016/J.Cbpa.2006.10.008 |
0.365 |
|
| 2006 |
Summerer D, Chen S, Wu N, Deiters A, Chin JW, Schultz PG. A genetically encoded fluorescent amino acid. Proceedings of the National Academy of Sciences of the United States of America. 103: 9785-9. PMID 16785423 DOI: 10.1073/Pnas.0603965103 |
0.818 |
|
| 2006 |
Chin JW. Modular approaches to expanding the functions of living matter. Nature Chemical Biology. 2: 304-11. PMID 16710339 DOI: 10.1038/Nchembio789 |
0.301 |
|
| 2006 |
Rackham O, Wang K, Chin JW. Functional epitopes at the ribosome subunit interface. Nature Chemical Biology. 2: 254-8. PMID 16582919 DOI: 10.1038/Nchembio783 |
0.784 |
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| 2006 |
Rackham O, Chin JW. Synthesizing cellular networks from evolved ribosome-mRNA pairs. Biochemical Society Transactions. 34: 328-9. PMID 16545106 DOI: 10.1042/Bst0340328 |
0.621 |
|
| 2006 |
Chin JW, Magliery TJ. Protein Expression by Expansion of the Genetic Code Reviews in Cell Biology and Molecular Medicine. DOI: 10.1002/3527600906.Mcb.200500044 |
0.818 |
|
| 2005 |
Rackham O, Chin JW. A network of orthogonal ribosome x mRNA pairs. Nature Chemical Biology. 1: 159-66. PMID 16408021 DOI: 10.1038/Nchembio719 |
0.635 |
|
| 2005 |
Rackham O, Chin JW. Cellular logic with orthogonal ribosomes. Journal of the American Chemical Society. 127: 17584-5. PMID 16351070 DOI: 10.1021/Ja055338D |
0.618 |
|
| 2005 |
Farrell IS, Toroney R, Hazen JL, Mehl RA, Chin JW. Photo-cross-linking interacting proteins with a genetically encoded benzophenone. Nature Methods. 2: 377-84. PMID 16170867 DOI: 10.1038/Nmeth0505-377 |
0.647 |
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| 2004 |
Schlieker C, Weibezahn J, Patzelt H, Tessarz P, Strub C, Zeth K, Erbse A, Schneider-Mergener J, Chin JW, Schultz PG, Bukau B, Mogk A. Substrate recognition by the AAA+ chaperone ClpB. Nature Structural & Molecular Biology. 11: 607-15. PMID 15208691 DOI: 10.1038/Nsmb787 |
0.506 |
|
| 2003 |
Deiters A, Cropp TA, Mukherji M, Chin JW, Anderson JC, Schultz PG. Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae. Journal of the American Chemical Society. 125: 11782-3. PMID 14505376 DOI: 10.1021/Ja0370037 |
0.776 |
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| 2003 |
Chin JW, Cropp TA, Anderson JC, Mukherji M, Zhang Z, Schultz PG. An expanded eukaryotic genetic code. Science (New York, N.Y.). 301: 964-7. PMID 12920298 DOI: 10.1126/Science.1084772 |
0.705 |
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| 2003 |
Chin JW, Cropp TA, Chu S, Meggers E, Schultz PG. Progress toward an expanded eukaryotic genetic code. Chemistry & Biology. 10: 511-9. PMID 12837384 DOI: 10.1016/S1074-5521(03)00123-6 |
0.721 |
|
| 2002 |
Chin JW, Schultz PG. In vivo photocrosslinking with unnatural amino Acid mutagenesis. Chembiochem : a European Journal of Chemical Biology. 3: 1135-7. PMID 12404640 DOI: 10.1002/1439-7633(20021104)3:11<1135::Aid-Cbic1135>3.0.Co;2-M |
0.497 |
|
| 2002 |
Chin JW, Martin AB, King DS, Wang L, Schultz PG. Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proceedings of the National Academy of Sciences of the United States of America. 99: 11020-4. PMID 12154230 DOI: 10.1073/Pnas.172226299 |
0.7 |
|
| 2002 |
Chin JW, Santoro SW, Martin AB, King DS, Wang L, Schultz PG. Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. Journal of the American Chemical Society. 124: 9026-7. PMID 12148987 DOI: 10.1021/Ja027007W |
0.819 |
|
| 2002 |
Rutledge SE, Chin JW, Schepartz A. A view to a kill: ligands for Bcl-2 family proteins. Current Opinion in Chemical Biology. 6: 479-85. PMID 12133724 DOI: 10.1016/S1367-5931(02)00352-6 |
0.772 |
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| 2001 |
Chin JW, Schepartz A. Design and Evolution of a Miniature Bcl-2 Binding Protein. Angewandte Chemie (International Ed. in English). 40: 3806-3809. PMID 29712146 DOI: 10.1002/1521-3773(20011015)40:20<3806::Aid-Anie3806>3.0.Co;2-B |
0.582 |
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| 2001 |
Chin JW, Schepartz A. Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid analysis and Professor Jennifer Doudna (Yale University) for use of a Perseptive Voyager-DE (MALDI-TOF) mass spectrometer. We are grateful also to Dr. Junying Yuan and Dr. Alexi Degterev (Harvard Medical School) for a generous gift of Bcl-X(L)-His(6) and Stacey E. Rutledge for helpful comments. This work was supported by the National Institutes of Health. Angewandte Chemie (International Ed. in English). 40: 3806-3809. PMID 11668539 DOI: 10.1002/1521-3773(20011015)40:20<3806::AID-ANIE3806>3.0.CO;2-B |
0.458 |
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| 2001 |
Chin JW, Schepartz A. Concerted evolution of structure and function in a miniature protein. Journal of the American Chemical Society. 123: 2929-30. PMID 11456999 DOI: 10.1021/Ja0056668 |
0.557 |
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| 2001 |
Chin JW, Grotzfeld RM, Fabian MA, Schepartz A. Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display. Bioorganic & Medicinal Chemistry Letters. 11: 1501-5. PMID 11412969 DOI: 10.1016/S0960-894X(01)00139-1 |
0.565 |
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| 1999 |
Chin JW, Kohler JJ, Schneider TL, Schepartz A. Gene regulation: protein escorts to the transcription ball. Current Biology : Cb. 9: R929-32. PMID 10607579 DOI: 10.1016/S0960-9822(00)80107-4 |
0.789 |
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