Year |
Citation |
Score |
2024 |
Wackelin DJ, Mao R, Sicinski KM, Zhao Y, Das A, Chen K, Arnold FH. Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society. PMID 38166100 DOI: 10.1021/jacs.3c11722 |
0.741 |
|
2023 |
Gao J, He XC, Liu YL, Ye ZP, Guan JP, Chen K, Xiang HY, Yang H. Photoredox/Nickel Dual Catalysis-Enabled Cross-Dehydrogenative C-H Amination of Indoles with Unactivated Amine. Organic Letters. PMID 37842950 DOI: 10.1021/acs.orglett.3c03073 |
0.324 |
|
2023 |
Deng KY, Wang ZW, Xie ZZ, He JT, Guan JP, Chen K, Xiang HY, Yang H. Photocatalysed C-H amidation of indoles enabled by -butyl alkyl((perfluoropyridin-4-yl)oxy)carbamate. Chemical Communications (Cambridge, England). PMID 37668188 DOI: 10.1039/d3cc03532h |
0.352 |
|
2023 |
Calvó-Tusell C, Liu Z, Chen K, Arnold FH, Garcia-Borràs M. Reversing the Enantioselectivity of Enzymatic Carbene N-H Insertion Through Mechanism-Guided Protein Engineering. Angewandte Chemie (International Ed. in English). e202303879. PMID 37260412 DOI: 10.1002/anie.202303879 |
0.583 |
|
2023 |
Yuan CP, Zheng Y, Xie ZZ, Deng KY, Chen HB, Xiang HY, Chen K, Yang H. Photosensitized Vicinal Sulfonylamination of Alkenes with Oxime Ester and DABCO·(SO). Organic Letters. 25: 1782-1786. PMID 36884012 DOI: 10.1021/acs.orglett.3c00559 |
0.301 |
|
2022 |
Li W, Zhang H, Chen K, Jiang H, Sun J, Zhu S. Palladium-catalyzed intramolecular enantioselective C(sp)-H insertion of donor/donor carbenes. Chemical Science. 13: 12396-12402. PMID 36382271 DOI: 10.1039/d2sc03524c |
0.305 |
|
2022 |
Kang QK, Li Y, Chen K, Zhu H, Wu WQ, Lin Y, Shi H. Corrigendum: Rhodium-Catalyzed Stereoselective Deuteration of Benzylic C-H Bonds via Reversible η -Coordination. Angewandte Chemie (International Ed. in English). 61: e202203820. PMID 35686879 DOI: 10.1002/anie.202203820 |
0.316 |
|
2021 |
Liu Z, Calvó-Tusell C, Zhou AZ, Chen K, Garcia-Borràs M, Arnold FH. Dual-function enzyme catalysis for enantioselective carbon-nitrogen bond formation. Nature Chemistry. 13: 1166-1172. PMID 34663919 DOI: 10.1038/s41557-021-00794-z |
0.582 |
|
2020 |
Chen K, Arnold FH. Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes. Journal of the American Chemical Society. PMID 32223130 DOI: 10.1021/Jacs.0C01313 |
0.575 |
|
2020 |
Zhou AZ, Chen K, Arnold FH. Enzymatic Lactone-Carbene C–H Insertion to Build Contiguous Chiral Centers Acs Catalysis. 10: 5393-5398. DOI: 10.1021/Acscatal.0C01349 |
0.556 |
|
2019 |
Brandenberg OF, Chen K, Arnold FH. Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds. Journal of the American Chemical Society. PMID 31070908 DOI: 10.1021/Jacs.9B02931 |
0.612 |
|
2019 |
Chen K, Huang X, Zhang SQ, Zhou AZ, Kan SBJ, Hong X, Arnold FH. Engineered Cytochrome -Catalyzed Lactone-Carbene B-H Insertion. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 30: 378-382. PMID 30930550 DOI: 10.1055/S-0037-1611662 |
0.58 |
|
2018 |
Chen K, Shi BF. Macrocyclic peptide construction through C-H activation strategy. Science Bulletin. 63: 1238-1240. PMID 36658859 DOI: 10.1016/j.scib.2018.09.008 |
0.457 |
|
2018 |
Zhang RK, Chen K, Huang X, Wohlschlager L, Renata H, Arnold FH. Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp C-H functionalization. Nature. PMID 30568304 DOI: 10.1038/S41586-018-0808-5 |
0.74 |
|
2018 |
Chen K, Zhang SQ, Brandenberg OF, Hong X, Arnold FH. Alternate heme ligation steers activity and selectivity in engineered cytochrome P450-catalyzed carbene transfer reactions. Journal of the American Chemical Society. PMID 30372623 DOI: 10.1021/Jacs.8B09613 |
0.601 |
|
2018 |
Knight AM, Kan SBJ, Lewis RD, Brandenberg OF, Chen K, Arnold FH. Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes. Acs Central Science. 4: 372-377. PMID 29632883 DOI: 10.1021/Acscentsci.7B00548 |
0.576 |
|
2018 |
Chen K, Huang X, Kan SBJ, Zhang RK, Arnold FH. Enzymatic construction of highly strained carbocycles. Science (New York, N.Y.). 360: 71-75. PMID 29622650 DOI: 10.1126/Science.Aar4239 |
0.52 |
|
2018 |
Brandenberg OF, Prier CK, Chen K, Knight AM, Wu Z, Arnold FH. Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes Acs Catalysis. 8: 2629-2634. DOI: 10.1021/Acscatal.7B04423 |
0.578 |
|
2017 |
Kan SBJ, Huang X, Gumulya Y, Chen K, Arnold FH. Genetically programmed chiral organoborane synthesis. Nature. 552: 132-136. PMID 29186119 DOI: 10.1038/Nature24996 |
0.6 |
|
2017 |
Ling PX, Fang SL, Yin XS, Zhang Q, Chen K, Shi BF. Palladium-catalyzed sequential monoarylation/amidation of C(sp(3))-H bonds: stereoselective synthesis of α-amino-β-lactams and anti-α,β-diamino acid. Chemical Communications (Cambridge, England). PMID 28555232 DOI: 10.1039/C7Cc02426F |
0.589 |
|
2017 |
Ling PX, Chen K, Shi BF. Palladium-catalyzed interannular meta-C-H arylation. Chemical Communications (Cambridge, England). PMID 28144666 DOI: 10.1039/C7Cc00110J |
0.588 |
|
2016 |
Kan SB, Lewis RD, Chen K, Arnold FH. Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life. Science (New York, N.Y.). 354: 1048-1051. PMID 27885032 DOI: 10.1126/Science.Aah6219 |
0.573 |
|
2016 |
Liao G, Yin XS, Chen K, Zhang Q, Zhang SQ, Shi BF. Stereoselective alkoxycarbonylation of unactivated C(sp3)-H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis. Nature Communications. 7: 12901. PMID 27678161 DOI: 10.1038/Ncomms12901 |
0.548 |
|
2016 |
Liu YJ, Liu YH, Zhang ZZ, Yan SY, Chen K, Shi BF. Divergent and Stereoselective Synthesis of β-Silyl-α-Amino Acids through Palladium-Catalyzed Intermolecular Silylation of Unactivated Primary and Secondary C-H Bonds. Angewandte Chemie (International Ed. in English). PMID 27678130 DOI: 10.1002/Anie.201607766 |
0.593 |
|
2016 |
Chen K, Li X, Zhang S, Shi B. Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids Organic Chemistry Frontiers. 3: 204-208. DOI: 10.1039/C5Qo00319A |
0.575 |
|
2015 |
Ling PX, Fang SL, Yin XS, Chen K, Sun BZ, Shi BF. Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp(3) )H and δ-CH Bonds with an Oxazoline-Carboxylate Auxiliary. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 17503-7. PMID 26769628 DOI: 10.1002/Chem.201502621 |
0.556 |
|
2015 |
Chen K, Li X, Zhang SQ, Shi BF. Synthesis of chiral α-hydroxy acids via palladium-catalyzed C(sp(3))-H alkylation of lactic acid. Chemical Communications (Cambridge, England). PMID 26679740 DOI: 10.1039/C5Cc07879B |
0.596 |
|
2015 |
Rao WH, Zhan BB, Chen K, Ling PX, Zhang ZZ, Shi BF. Pd(II)-Catalyzed Direct Sulfonylation of Unactivated C(sp(3))-H Bonds with Sodium Sulfinates. Organic Letters. PMID 26110825 DOI: 10.1021/Acs.Orglett.5B01634 |
0.532 |
|
2015 |
Zhang Q, Yin XS, Chen K, Zhang SQ, Shi BF. Stereoselective Synthesis of Chiral β-Fluoro α-Amino Acids via Pd(II)-Catalyzed Fluorination of Unactivated Methylene C(sp(3))-H Bonds: Scope and Mechanistic Studies. Journal of the American Chemical Society. 137: 8219-26. PMID 26067591 DOI: 10.1021/Jacs.5B03989 |
0.581 |
|
2015 |
Chen K, Zhang SQ, Jiang HZ, Xu JW, Shi BF. Practical synthesis of anti-β-hydroxy-α-amino acids by Pd(II) -catalyzed sequential C(sp(3) )-H functionalization. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 3264-70. PMID 25589007 DOI: 10.1002/Chem.201405942 |
0.553 |
|
2014 |
Chen K, Zhang SQ, Xu JW, Hu F, Shi BF. A general and practical palladium-catalyzed monoarylation of β-methyl C(sp³)-H of alanine. Chemical Communications (Cambridge, England). 50: 13924-7. PMID 25259442 DOI: 10.1039/C4Cc06652A |
0.54 |
|
2014 |
Chen K, Shi BF. Sulfonamide-promoted palladium(II)-catalyzed alkylation of unactivated methylene C(sp3)-H bonds with alkyl iodides. Angewandte Chemie (International Ed. in English). 53: 11950-4. PMID 25213367 DOI: 10.1002/Anie.201407848 |
0.562 |
|
2014 |
Zhang Q, Chen K, Shi BF. Recent progress in the synthesis of functionalized β-lactams through transition-metal-catalyzed C(sp3)-H amidation Synlett. 25: 1941-1945. DOI: 10.1055/S-0033-1338645 |
0.534 |
|
2013 |
Zhang Q, Chen K, Rao W, Zhang Y, Chen FJ, Shi BF. Stereoselective synthesis of chiral α-amino-β-lactams through palladium(II)-catalyzed sequential monoarylation/amidation of C(sp(3) )-H bonds. Angewandte Chemie (International Ed. in English). 52: 13588-92. PMID 24174011 DOI: 10.1002/Anie.201306625 |
0.546 |
|
1993 |
Chen K, Arnold FH. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. Proceedings of the National Academy of Sciences of the United States of America. 90: 5618-22. PMID 8516309 DOI: 10.1073/Pnas.90.12.5618 |
0.498 |
|
1992 |
Economou C, Chen K, Arnold FH. Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E. Biotechnology and Bioengineering. 39: 658-62. PMID 18600995 DOI: 10.1002/Bit.260390610 |
0.469 |
|
1992 |
Martinez P, Van Dam ME, Robinson AC, Chen K, Arnold FH. Stabilization of substilisin E in organic solvents by site-directed mutagenesis. Biotechnology and Bioengineering. 39: 141-7. PMID 18600924 DOI: 10.1002/Bit.260390204 |
0.443 |
|
1991 |
Chen KQ, Arnold FH. Enzyme engineering for nonaqueous solvents: random mutagenesis to enhance activity of subtilisin E in polar organic media. Bio/Technology (Nature Publishing Company). 9: 1073-7. PMID 1367624 DOI: 10.1038/Nbt1191-1073 |
0.471 |
|
1991 |
Chen KQ, Robinson AC, Van Dam ME, Martinez P, Economou C, Arnold FH. Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media. Biotechnology Progress. 7: 125-9. PMID 1367168 DOI: 10.1021/Bp00008A007 |
0.455 |
|
Show low-probability matches. |