Terry D. Connell - Publications

Affiliations: 
State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Microbiology Biology

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zalem D, Juhás M, Terrinoni M, King-Lyons N, Lebens M, Varrot A, Connell TD, Teneberg S. Characterization of the ganglioside recognition profile of Escherichia coli heat-labile enterotoxin LT-IIc. Glycobiology. PMID 34972864 DOI: 10.1093/glycob/cwab133  0.347
2020 Johnson TA, Ritter MK, Knapp MA, Rainer RO, King-Lyons ND, Connell TD, Arce S. Abstract A25: Differentiation of human naive T cells to various effector memory cell subtypes correlates with increased binding of the B subunit of Type-IIb heat-labile enterotoxin (LT-IIb-B5) to its cognate ganglioside receptors Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm19-A25  0.397
2020 Ritter MK, Knapp MA, Johnson TA, King-Lyons ND, Mandell L, Grier JT, Connell TD, Arce S. Abstract 4525: Dynamic changes in patterns of ganglioside expression characterize maturation of cytotoxic T cells and natural killer cells into effector cells and suggest a close relationship between the two cell types Immunology. DOI: 10.1158/1538-7445.Am2020-4525  0.322
2018 Masso-Welch P, Girald Berlingeri S, King-Lyons ND, Mandell L, Hu J, Greene CJ, Federowicz M, Cao P, Connell TD, Heakal Y. LT-IIc, A Bacterial Type II Heat-Labile Enterotoxin, Induces Specific Lethality in Triple Negative Breast Cancer Cells by Modulation of Autophagy and Induction of Apoptosis and Necroptosis. International Journal of Molecular Sciences. 20. PMID 30587795 DOI: 10.3390/Ijms20010085  0.678
2018 Masso-Welch PA, Berlingeri SG, King-Lyons ND, Hu JC, Greene C, Mandell L, Federowicz M, Connell TD, Heakal Y. Abstract 3968: Bacterial heat labile enterotoxin LT-IIc effects autophagy and cell death in human TNBC Cancer Research. 78: 3968-3968. DOI: 10.1158/1538-7445.Am2018-3968  0.69
2017 Lee CH, Hajishengallis G, Connell TD. Dendritic cell-mediated mechanisms triggered by LT-IIa-B₅, a mucosal adjuvant derived from a type II heat-labile enterotoxin of Escherichia coli. Journal of Microbiology and Biotechnology. PMID 28144014 DOI: 10.4014/Jmb.1611.11072  0.467
2016 El-Kassas S, Odemuyiwa S, Hajishengallis G, Connell TD, Nashar TO. Expression and Regulation of Cholecystokinin Receptor in the Chicken's Immune Organs and Cells. Journal of Clinical & Cellular Immunology. 7. PMID 28149670 DOI: 10.4172/2155-9899.1000471  0.411
2016 Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J, Khader SA. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nature Communications. 7: 13894. PMID 28004802 DOI: 10.1038/Ncomms13894  0.346
2016 Greene CJ, Hu JC, Vance DJ, Rong Y, Mandell L, King-Lyons N, Masso-Welch P, Mantis NJ, Connell TD. Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils. Journal of Leukocyte Biology. PMID 27059843 DOI: 10.1189/Jlb.3A0415-153Rr  0.717
2016 Greene CJ, Marks LR, Hu JC, Reddinger R, Mandell L, Roche-Hakansson H, King-Lyons ND, Connell TD, Hakansson AP. A novel strategy to protect against influenza-induced pneumococcal disease without interfering with commensal colonization. Infection and Immunity. PMID 27001538 DOI: 10.1128/Iai.01478-15  0.682
2015 Hu JC, Greene CJ, King-Lyons ND, Connell TD. The Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits. Plos One. 10: e0142942. PMID 26565800 DOI: 10.1371/Journal.Pone.0142942  0.762
2015 Vance DJ, Greene CJ, Rong Y, Mandell LM, Connell TD, Mantis NJ. Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens. Clinical and Vaccine Immunology : Cvi. PMID 26491037 DOI: 10.1128/Cvi.00402-15  0.714
2015 El-Kassas S, Faraj R, Martin K, Hajishengallis G, Connell TD, Nashar T. Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits. Cellular Immunology. 295: 150-62. PMID 25880107 DOI: 10.1016/J.Cellimm.2015.02.014  0.493
2014 Hu JC, Mathias-Santos C, Greene CJ, King-Lyons ND, Rodrigues JF, Hajishengallis G, Ferreira LC, Connell TD. Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen. Plos One. 9: e113978. PMID 25536061 DOI: 10.1371/Journal.Pone.0113978  0.718
2014 Gopal R, Rangel-Moreno J, Fallert Junecko BA, Mallon DJ, Chen K, Pociask DA, Connell TD, Reinhart TA, Alcorn JF, Ross TM, Kolls JK, Khader SA. Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection. The American Journal of Pathology. 184: 55-63. PMID 24183780 DOI: 10.1016/J.Ajpath.2013.09.012  0.353
2013 Greene CJ, Chadwick CM, Mandell LM, Hu JC, O'Hara JM, Brey RN, Mantis NJ, Connell TD. LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity. Plos One. 8: e69678. PMID 23936344 DOI: 10.1371/Journal.Pone.0069678  0.69
2013 Gopal R, Rangel-Moreno J, Slight S, Lin Y, Nawar HF, Fallert Junecko BA, Reinhart TA, Kolls J, Randall TD, Connell TD, Khader SA. Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis. Mucosal Immunology. 6: 972-84. PMID 23299616 DOI: 10.1038/Mi.2012.135  0.742
2013 Hajishengallis G, Connell TD. Type II heat-labile enterotoxins: structure, function, and immunomodulatory properties. Veterinary Immunology and Immunopathology. 152: 68-77. PMID 23137790 DOI: 10.1016/J.Vetimm.2012.09.034  0.374
2013 Berenson CS, Nawar HF, Kruzel RL, Mandell LM, Connell TD. Ganglioside-binding specificities of E. coli enterotoxin LT-IIc: Importance of long-chain fatty acyl ceramide Glycobiology. 23: 23-31. PMID 22917572 DOI: 10.1093/Glycob/Cws123  0.756
2013 Huang H, Lyons N, Connell T, Pralle A. The Immunomodulator Enterotoxin Influences BCR Signaling by Stabilizing Lipid Domains Biophysical Journal. 104: 246a. DOI: 10.1016/J.Bpj.2012.11.1384  0.339
2012 Cody V, Pace J, Nawar HF, King-Lyons N, Liang S, Connell TD, Hajishengallis G. Structure-activity correlations of variant forms of the B pentamer of Escherichia coli type II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding. Acta Crystallographica. Section D, Biological Crystallography. 68: 1604-12. PMID 23151625 DOI: 10.1107/S0907444912038917  0.78
2012 Casey TA, Connell TD, Holmes RK, Whipp SC. Evaluation of heat-labile enterotoxins type IIa and type IIb in the pathogenicity of enterotoxigenic Escherichia coli for neonatal pigs. Veterinary Microbiology. 159: 83-9. PMID 22480773 DOI: 10.1016/J.Vetmic.2012.03.018  0.359
2011 Lee CH, Masso-Welch P, Hajishengallis G, Connell TD. TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin. Journal of Leukocyte Biology. 90: 911-21. PMID 21791597 DOI: 10.1189/Jlb.0511236  0.48
2011 Mathias-Santos C, Rodrigues JF, Sbrogio-Almeida ME, Connell TD, Ferreira LC. Distinctive immunomodulatory and inflammatory properties of the Escherichia coli type II heat-labile enterotoxin LT-IIa and its B pentamer following intradermal administration. Clinical and Vaccine Immunology : Cvi. 18: 1243-51. PMID 21677110 DOI: 10.1128/Cvi.00012-11  0.455
2011 Myneni SR, Settem RP, Connell TD, Keegan AD, Gaffen SL, Sharma A. TLR2 signaling and Th2 responses drive Tannerella forsythia-induced periodontal bone loss. Journal of Immunology (Baltimore, Md. : 1950). 187: 501-9. PMID 21632710 DOI: 10.4049/Jimmunol.1100683  0.336
2011 Nawar HF, Greene CJ, Lee CH, Mandell LM, Hajishengallis G, Connell TD. LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb Vaccine. 29: 721-727. PMID 21095251 DOI: 10.1016/J.Vaccine.2010.11.020  0.799
2010 Nawar HF, King-Lyons ND, Hu JC, Pasek RC, Connell TD. LT-IIc, a new member of the type II heat-labile enterotoxin family encoded by an Escherichia coli strain obtained from a nonmammalian host. Infection and Immunity. 78: 4705-13. PMID 20713622 DOI: 10.1128/Iai.00730-10  0.773
2010 Nawar HF, Berenson CS, Hajishengallis G, Takematsu H, Mandell L, Clare RL, Connell TD. Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I) Clinical and Vaccine Immunology. 17: 969-978. PMID 20392887 DOI: 10.1128/Cvi.00076-10  0.786
2010 Lee CH, Nawar HF, Mandell L, Liang S, Hajishengallis G, Connell TD. Enhanced antigen uptake by dendritic cells induced by the B pentamer of the type II heat-labile enterotoxin LT-IIa requires engagement of TLR2 Vaccine. 28: 3696-3705. PMID 20332049 DOI: 10.1016/J.Vaccine.2010.03.016  0.792
2010 Burgos JM, King-Lyons ND, Connell TD. Expression of BfrH, a putative siderophore receptor of Bordetella bronchiseptica, is regulated by iron, Fur1, and the extracellular function sigma factor EcfI. Infection and Immunity. 78: 1147-62. PMID 20008538 DOI: 10.1128/Iai.00961-09  0.383
2010 Berenson CS, Nawar HF, Yohe HC, Castle SA, Ashline DJ, Reinhold VN, Hajishengallis G, Connell TD. Mammalian cell ganglioside-binding specificities of E. coli enterotoxins LT-IIb and variant LT-IIb(T13I). Glycobiology. 20: 41-54. PMID 19749203 DOI: 10.1093/Glycob/Cwp141  0.749
2009 Liang S, Hosur KB, Nawar HF, Russell MW, Connell TD, Hajishengallis G. In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli. Vaccine. 27: 4302-8. PMID 19450646 DOI: 10.1016/J.Vaccine.2009.05.027  0.794
2009 Taube S, Perry JW, Yetming K, Patel SP, Auble H, Shu L, Nawar HF, Lee CH, Connell TD, Shayman JA, Wobus CE. Ganglioside-linked terminal sialic acid moieties on murine macrophages function as attachment receptors for murine noroviruses. Journal of Virology. 83: 4092-101. PMID 19244326 DOI: 10.1128/Jvi.02245-08  0.744
2009 Liang S, Hosur KB, Lu S, Nawar HF, Weber BR, Tapping RI, Connell TD, Hajishengallis G. Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer. Journal of Immunology (Baltimore, Md. : 1950). 182: 2978-85. PMID 19234193 DOI: 10.4049/Jimmunol.0803737  0.775
2009 Liang S, Hosur K, Lu S, Nawar H, Tapping R, Connell T, Hajishengallis G. S.80. Type-IIb Enterotoxin (LT-IIb-B5) Binds to TLR2/1 to Stimulate Dendritic Cells and Differentially Regulates T Cell Subsets Clinical Immunology. 131: S154. DOI: 10.1016/J.Clim.2009.03.454  0.768
2007 Connell TD. Cholera toxin, LT-I, LT-IIa and LT-IIb: the critical role of ganglioside binding in immunomodulation by type I and type II heat-labile enterotoxins. Expert Review of Vaccines. 6: 821-34. PMID 17931161 DOI: 10.1586/14760584.6.5.821  0.486
2007 Mocny JC, Olson JS, Connell TD. Passively released heme from hemoglobin and myoglobin is a potential source of nutrient iron for Bordetella bronchiseptica. Infection and Immunity. 75: 4857-66. PMID 17664260 DOI: 10.1128/Iai.00407-07  0.736
2007 King-Lyons ND, Smith KF, Connell TD. Expression of hurP, a gene encoding a prospective site 2 protease, is essential for heme-dependent induction of bhuR in Bordetella bronchiseptica. Journal of Bacteriology. 189: 6266-75. PMID 17586630 DOI: 10.1128/Jb.00629-07  0.396
2007 Liang S, Wang M, Triantafilou K, Triantafilou M, Nawar HF, Russell MW, Connell TD, Hajishengallis G. The A subunit of type IIb enterotoxin (LT-IIb) suppresses the proinflammatory potential of the B subunit and its ability to recruit and interact with TLR2. Journal of Immunology (Baltimore, Md. : 1950). 178: 4811-9. PMID 17404262 DOI: 10.4049/Jimmunol.178.8.4811  0.79
2007 Liang S, Wang M, Tapping RI, Stepensky V, Nawar HF, Triantafilou M, Triantafilou K, Connell TD, Hajishengallis G. Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin. The Journal of Biological Chemistry. 282: 7532-42. PMID 17227759 DOI: 10.1074/Jbc.M611722200  0.784
2007 Arce S, Nawar HF, Muehlinghaus G, Russell MW, Connell TD. In vitro induction of immunoglobulin A (IgA)- and IgM-secreting plasma blasts by cholera toxin depends on T-cell help and is mediated by CD154 up-regulation and inhibition of gamma interferon synthesis. Infection and Immunity. 75: 1413-23. PMID 17220318 DOI: 10.1128/Iai.01367-06  0.75
2007 Nawar HF, Arce S, Russell MW, Connell TD. Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants. Infection and Immunity. 75: 621-33. PMID 17118982 DOI: 10.1128/Iai.01009-06  0.792
2006 Sebaihia M, Preston A, Maskell DJ, Kuzmiak H, Connell TD, King ND, Orndorff PE, Miyamoto DM, Thomson NR, Harris D, Goble A, Lord A, Murphy L, Quail MA, Rutter S, et al. Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction. Journal of Bacteriology. 188: 6002-15. PMID 16885469 DOI: 10.1128/Jb.01927-05  0.361
2005 Hajishengallis G, Arce S, Gockel CM, Connell TD, Russell MW. Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: Applications for oral infections Journal of Dental Research. 84: 1104-1116. PMID 16304439 DOI: 10.1177/154405910508401205  0.499
2005 van Ginkel FW, Jackson RJ, Yoshino N, Hagiwara Y, Metzger DJ, Connell TD, Vu HL, Martin M, Fujihashi K, McGhee JR. Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract. Infection and Immunity. 73: 6892-902. PMID 16177369 DOI: 10.1128/Iai.73.10.6892-6902.2005  0.431
2005 Arce S, Nawar HF, Russell MW, Connell TD. Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cells. Infection and Immunity. 73: 2718-27. PMID 15845474 DOI: 10.1128/Iai.73.5.2718-2727.2005  0.756
2005 King ND, Kirby AE, Connell TD. Transcriptional control of the rhuIR-bhuRSTUV heme acquisition locus in Bordetella avium. Infection and Immunity. 73: 1613-24. PMID 15731061 DOI: 10.1128/Iai.73.3.1613-1624.2005  0.65
2005 Hajishengallis G, Tapping RI, Martin MH, Nawar H, Lyle EA, Russell MW, Connell TD. Toll-like receptor 2 mediates cellular activation by the B subunits of type II heat-labile enterotoxins. Infection and Immunity. 73: 1343-9. PMID 15731031 DOI: 10.1128/Iai.73.3.1343-1349.2005  0.801
2005 Nawar HF, Arce S, Russell MW, Connell TD. Mucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activities. Infection and Immunity. 73: 1330-42. PMID 15731030 DOI: 10.1128/Iai.73.3.1330-1342.2005  0.791
2004 Hajishengallis G, Nawar H, Tapping RI, Russell MW, Connell TD. The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells. Infection and Immunity. 72: 6351-8. PMID 15501764 DOI: 10.1128/Iai.72.11.6351-6358.2004  0.768
2004 Kirby AE, King ND, Connell TD. RhuR, an extracytoplasmic function sigma factor activator, is essential for heme-dependent expression of the outer membrane heme and hemoprotein receptor of Bordetella avium. Infection and Immunity. 72: 896-907. PMID 14742534 DOI: 10.1128/Iai.72.2.896-907.2004  0.68
2002 Murphy ER, Sacco RE, Dickenson A, Metzger DJ, Hu Y, Orndorff PE, Connell TD. BhuR, a virulence-associated outer membrane protein of Bordetella avium, is required for the acquisition of iron from heme and hemoproteins. Infection and Immunity. 70: 5390-403. PMID 12228263 DOI: 10.1128/Iai.70.10.5390-5403.2002  0.405
2002 Folster JP, Connell TD. The extracellular transport signal of the Vibrio cholerae endochitinase (ChiA) is a structural motif located between amino acids 75 and 555. Journal of Bacteriology. 184: 2225-34. PMID 11914354 DOI: 10.1128/Jb.184.8.2225-2234.2002  0.645
2001 Kirby AE, Metzger DJ, Murphy ER, Connell TD. Heme utilization in Bordetella avium is regulated by RhuI, a heme-responsive extracytoplasmic function sigma factor. Infection and Immunity. 69: 6951-61. PMID 11598070 DOI: 10.1128/Iai.69.11.6951-6961.2001  0.676
2001 Martin M, Metzger DJ, Michalek SM, Connell TD, Russell MW. Distinct cytokine regulation by cholera toxin and type II heat-labile toxins involves differential regulation of CD40 ligand on CD4+ T cells Infection and Immunity. 69: 4486-4492. PMID 11401990 DOI: 10.1128/Iai.69.7.4486-4492.2001  0.395
2001 Martin M, Hajishengallis G, Metzger DJ, Michalek SM, Connell TD, Russell MW. Recombinant antigen-enterotoxin A2/B chimeric mucosal immunogens differentially enhance antibody responses and B7-dependent costimulation of CD4+ T cells Infection and Immunity. 69: 252-261. PMID 11119513 DOI: 10.1128/Iai.69.1.252-261.2001  0.466
2000 Martin M, Metzger DJ, Michalek SM, Connell TD, Russell MW. Comparative analysis of the mucosal adjuvanticity of the type II heat- labile enterotoxins LT-IIa and LT-IIb Infection and Immunity. 68: 281-287. PMID 10603399 DOI: 10.1128/Iai.68.1.281-287.2000  0.416
1999 Murphy ER, Dickenson A, Militello KT, Connell TD. Genetic characterization of wild-type and mutant fur genes of Bordetella avium. Infection and Immunity. 67: 3160-5. PMID 10338537 DOI: 10.1128/Iai.67.6.3160-3165.1999  0.384
1998 Connell TD, Metzger DJ, Lynch J, Folster JP. Endochitinase is transported to the extracellular milieu by the eps-encoded general secretory pathway of Vibrio cholerae. Journal of Bacteriology. 180: 5591-600. PMID 9791107 DOI: 10.1128/Jb.180.21.5591-5600.1998  0.681
1998 Connell TD, Metzger D, Sfintescu C, Evans RT. Immunostimulatory activity of LT-IIa, a type II heat-labile enterotoxin of Escherichia coli Immunology Letters. 62: 117-120. PMID 9698108 DOI: 10.1016/S0165-2478(98)00038-8  0.473
1998 Connell TD, Dickenson A, Martone AJ, Militello KT, Filiatraut MJ, Hayman ML, Pitula J. Iron starvation of Bordetella avium stimulates expression of five outer membrane proteins and regulates a gene involved in acquiring iron from serum Infection and Immunity. 66: 3597-3605. PMID 9673238 DOI: 10.1128/Iai.66.8.3597-3605.1998  0.326
1996 Van Den Akker F, Sarfaty S, Twiddy EM, Connell TD, Holmes RK, Hol WGJ. Crystal structure of a new heat-labile enterotoxin, LT-IIb Structure. 4: 665-678. PMID 8805549 DOI: 10.1016/S0969-2126(96)00073-1  0.423
1995 Connell TD, Holmes RK. Mutational analysis of the ganglioside-binding activity of the type II escherichia coli heat-labile enterotoxin LT-IIb Molecular Microbiology. 16: 21-31. PMID 7651134 DOI: 10.1111/J.1365-2958.1995.Tb02388.X  0.475
1995 Connell TD, Metzger DJ, Wang M, Jobling MG, Holmes RK. Initial studies of the structural signal for extracellular transport of cholera toxin and other proteins recognized by Vibrio cholerae Infection and Immunity. 63: 4091-4098. PMID 7558324 DOI: 10.1128/Iai.63.10.4091-4098.1995  0.404
1992 Connell TD, Holmes RK. Molecular genetic analysis of ganglioside GD1b-binding activity of Escherichia coli type IIa heat-labile enterotoxin by use of random and site- directed mutagenesis Infection and Immunity. 60: 63-70. PMID 1729197 DOI: 10.1128/Iai.60.1.63-70.1992  0.44
1992 Connell TD, Holmes RK. Characterization of hybrid toxins produced in Escherichia coli by assembly of A and B polypeptides from type I and type II heat-labile enterotoxins Infection and Immunity. 60: 1653-1661. PMID 1548088 DOI: 10.1128/Iai.60.4.1653-1661.1992  0.439
1988 Connell TD, Black WJ, Kawula TH, Barritt DS, Dempsey JA, Kverneland K, Stephenson A, Schepart BS, Murphy GL, Cannon JG. Recombination among protein II genes of Neisseria gonorrhoeae generates new coding sequences and increases structural variability in the protein II family Molecular Microbiology. 2: 227-236. PMID 2454382 DOI: 10.1111/J.1365-2958.1988.Tb00024.X  0.322
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