Year |
Citation |
Score |
2021 |
Wan Q, Bennett BC, Wymore T, Li Z, Wilson MA, Brooks CL, Langan P, Kovalevsky A, Dealwis CG. Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis. Acs Catalysis. 11: 5873-5884. PMID 34055457 DOI: 10.1021/acscatal.1c00417 |
0.73 |
|
2016 |
Knappenberger AJ, Mohammed FA, Viswanathan R, Dealwis CG, Harris ME. Nucleoside analog triphosphates allosterically regulate human ribonucleotide reductase and identify chemical determinants that drive substrate specificity. Biochemistry. PMID 27634056 DOI: 10.1021/Acs.Biochem.6B00594 |
0.311 |
|
2014 |
Wan Q, Bennett BC, Wilson MA, Kovalevsky A, Langan P, Howell EE, Dealwis C. Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 111: 18225-30. PMID 25453083 DOI: 10.1073/Pnas.1415856111 |
0.749 |
|
2014 |
Wan Q, Kovalevsky AY, Wilson MA, Bennett BC, Langan P, Dealwis C. Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+. Acta Crystallographica. Section F, Structural Biology Communications. 70: 814-8. PMID 24915100 DOI: 10.1107/S2053230X1400942X |
0.732 |
|
2012 |
Ahmad MF, Wan Q, Jha S, Motea E, Berdis A, Dealwis C. Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Molecular Cancer Therapeutics. 11: 2077-86. PMID 22933704 DOI: 10.1158/1535-7163.Mct-12-0199 |
0.433 |
|
2011 |
Wan Q, Ahmad MF, Fairman J, Gorzelle B, de la Fuente M, Dealwis C, Maguire ME. X-ray crystallography and isothermal titration calorimetry studies of the Salmonella zinc transporter ZntB. Structure (London, England : 1993). 19: 700-10. PMID 21565704 DOI: 10.1016/J.Str.2011.02.011 |
0.388 |
|
2011 |
Miyagi M, Wan Q, Ahmad MF, Gokulrangan G, Tomechko SE, Bennett B, Dealwis C. Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase. Plos One. 6: e17055. PMID 21359214 DOI: 10.1371/Journal.Pone.0017055 |
0.719 |
|
2009 |
Sun D, Xu H, Wijerathna SR, Dealwis C, Lee RE. Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors. Chemmedchem. 4: 1649-56. PMID 19681093 DOI: 10.1002/Cmdc.200900236 |
0.404 |
|
2009 |
Gardberg A, Dice L, Pridgen K, Ko J, Patterson P, Ou S, Wetzel R, Dealwis C. Structures of Aβ-related peptide-monoclonal antibody complexes Biochemistry. 48: 5210-5217. PMID 19385664 DOI: 10.1021/Bi9001216 |
0.335 |
|
2009 |
Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. Journal of Structural Biology. 166: 162-71. PMID 19374017 DOI: 10.1016/J.Jsb.2009.01.001 |
0.752 |
|
2008 |
Xu H, Fairman JW, Wijerathna SR, Kreischer NR, LaMacchia J, Helmbrecht E, Cooperman BS, Dealwis C. The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase: a conformationally flexible pharmacophore. Journal of Medicinal Chemistry. 51: 4653-9. PMID 18610997 DOI: 10.1021/Jm800350U |
0.383 |
|
2008 |
Bennett BC, Gardberg AS, Blair MD, Dealwis CG. On the determinants of amide backbone exchange in proteins: a neutron crystallographic comparative study. Acta Crystallographica. Section D, Biological Crystallography. 764-83. PMID 18566512 DOI: 10.1107/S0907444908012845 |
0.736 |
|
2008 |
Langan P, Fisher Z, Kovalevsky A, Mustyakimov M, Sutcliffe Valone A, Unkefer C, Waltman MJ, Coates L, Adams PD, Afonine PV, Bennett B, Dealwis C, Schoenborn BP. Protein structures by spallation neutron crystallography. Journal of Synchrotron Radiation. 15: 215-8. PMID 18421142 DOI: 10.1107/S0909049508000824 |
0.728 |
|
2007 |
Gardberg AS, Dice LT, Ou S, Rich RL, Helmbrecht E, Ko J, Wetzel R, Myszka DG, Patterson PH, Dealwis C. Molecular basis for passive immunotherapy of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 15659-64. PMID 17895381 DOI: 10.1073/Pnas.0705888104 |
0.313 |
|
2007 |
Bennett BC, Xu H, Simmerman RF, Lee RE, Dealwis CG. Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase. Journal of Medicinal Chemistry. 50: 4374-81. PMID 17696333 DOI: 10.1021/Jm070319V |
0.717 |
|
2006 |
Bennett B, Langan P, Coates L, Mustyakimov M, Schoenborn B, Howell EE, Dealwis C. Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proceedings of the National Academy of Sciences of the United States of America. 103: 18493-8. PMID 17130456 DOI: 10.1073/Pnas.0604977103 |
0.753 |
|
2006 |
Xu H, Faber C, Uchiki T, Racca J, Dealwis C. Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly. Proceedings of the National Academy of Sciences of the United States of America. 103: 4028-33. PMID 16537480 DOI: 10.1073/Pnas.0600440103 |
0.762 |
|
2006 |
Xu H, Faber C, Uchiki T, Fairman JW, Racca J, Dealwis C. Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation. Proceedings of the National Academy of Sciences of the United States of America. 103: 4022-7. PMID 16537479 DOI: 10.1073/Pnas.0600443103 |
0.774 |
|
2005 |
Bennett BC, Meilleur F, Myles DA, Howell EE, Dealwis CG. Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate. Acta Crystallographica. Section D, Biological Crystallography. 61: 574-9. PMID 15858267 DOI: 10.1107/S0907444905004804 |
0.735 |
|
2005 |
Sharp JS, Guo JT, Uchiki T, Xu Y, Dealwis C, Hettich RL. Photochemical surface mapping of C14S-Sml1p for constrained computational modeling of protein structure. Analytical Biochemistry. 340: 201-12. PMID 15840492 DOI: 10.1016/J.Ab.2005.02.005 |
0.756 |
|
2004 |
Wall JS, Gupta V, Wilkerson M, Schell M, Loris R, Adams P, Solomon A, Stevens F, Dealwis C. Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins. Journal of Molecular Recognition : Jmr. 17: 323-31. PMID 15227639 DOI: 10.1002/Jmr.681 |
0.392 |
|
2004 |
Gupta V, Peterson CB, Dice LT, Uchiki T, Racca J, Guo JT, Xu Y, Hettich R, Zhao X, Rothstein R, Dealwis CG. Sml1p is a dimer in solution: characterization of denaturation and renaturation of recombinant Sml1p. Biochemistry. 43: 8568-78. PMID 15222768 DOI: 10.1021/Bi0361721 |
0.765 |
|
2004 |
Dealwis C, Wall J. Towards understanding the structure-function relationship of human amyloid disease. Current Drug Targets. 5: 159-71. PMID 15011949 DOI: 10.2174/1389450043490550 |
0.376 |
|
2004 |
Uchiki T, Dice LT, Hettich RL, Dealwis C. Identification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1. The Journal of Biological Chemistry. 279: 11293-303. PMID 14684746 DOI: 10.1074/Jbc.M309751200 |
0.739 |
|
2002 |
Uchiki T, Hettich R, Gupta V, Dealwis C. Characterization of monomeric and dimeric forms of recombinant Sml1p-histag protein by electrospray mass spectrometry. Analytical Biochemistry. 301: 35-48. PMID 11811965 DOI: 10.1006/Abio.2001.5492 |
0.759 |
|
1999 |
Sachpatzidis A, Dealwis C, Lubetsky JB, Liang PH, Anderson KS, Lolis E. Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase. Biochemistry. 38: 12665-74. PMID 10504236 DOI: 10.1021/Bi9907734 |
0.337 |
|
1999 |
Lubetsky JB, Swope M, Dealwis C, Blake P, Lolis E. Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. Biochemistry. 38: 7346-54. PMID 10353846 DOI: 10.1021/Bi990306M |
0.303 |
|
1995 |
Dealwis CG, Brennan C, Christianson K, Mandecki W, Abad-Zapatero C. Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase. Biochemistry. 34: 13967-73. PMID 7577993 DOI: 10.1021/bi00043a001 |
0.336 |
|
1994 |
Dealwis CG, Frazao C, Badasso M, Cooper JB, Tickle IJ, Driessen H, Blundell TL, Murakami K, Miyazaki H, Sueiras-Diaz J. X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen. Journal of Molecular Biology. 236: 342-60. PMID 8107115 DOI: 10.1006/jmbi.1994.1139 |
0.365 |
|
1993 |
Lisgarten JN, Gupta V, Maes D, Wyns L, Zegers I, Palmer RA, Dealwis CG, Aguilar CF, Hemmings AM. Structure of the crystalline complex of cytidylic acid (2'-CMP) with ribonuclease at 1.6 A resolution. Conservation of solvent sites in RNase-A high-resolution structures. Acta Crystallographica. Section D, Biological Crystallography. 49: 541-7. PMID 15299491 DOI: 10.1107/S090744499300719X |
0.388 |
|
1993 |
Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT. Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors. Journal of Medicinal Chemistry. 36: 3809-20. PMID 8254610 |
0.315 |
|
1992 |
Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HPC, Newman M, Aguilar C, Wood SP, Blundell TL, Hobart PM, Geoghegan KF, Ammirati MJ, et al. X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins Nature. 357: 466-472. PMID 1608447 DOI: 10.1038/357466a0 |
0.336 |
|
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