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Kevin J. Yarema - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Biomedical Engineering
Website:
https://engineering.jhu.edu/faculty/kevin-yarema/
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67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dammen-Brower K, Tan E, Almaraz RT, Du J, Yarema KJ. Protocol Considerations for In Vitro Metabolic Glycoengineering of Non-Natural Glycans. Current Protocols. 3: e822. PMID 37358193 DOI: 10.1002/cpz1.822  0.396
2023 Saeui CT, Shah SR, Fernandez-Gil BI, Zhang C, Agatemor C, Dammen-Brower K, Mathew MP, Buettner M, Gowda P, Khare P, Otamendi-Lopez A, Yang S, Zhang H, Le A, Quinoñes-Hinojosa A, ... Yarema KJ, et al. Anticancer Properties of Hexosamine Analogs Designed to Attenuate Metabolic Flux through the Hexosamine Biosynthetic Pathway. Acs Chemical Biology. PMID 36626752 DOI: 10.1021/acschembio.2c00784  0.736
2022 Ludwig SD, Bernstein ZJ, Agatemor C, Dammen-Brower K, Ruffolo J, Rosas JM, Post JD, Cole RN, Yarema KJ, Spangler JB. A versatile design platform for glycoengineering therapeutic antibodies. Mabs. 14: 2095704. PMID 35815437 DOI: 10.1080/19420862.2022.2095704  0.621
2022 Du J, Liu X, Yarema KJ, Jia X. Glycoengineering human neural stem cells (hNSCs) for adhesion improvement using a novel thiol-modified N-acetylmannosamine (ManNAc) analog. Materials Science & Engineering. C, Materials For Biological Applications. 112675. PMID 35599100 DOI: 10.1016/j.msec.2022.112675  0.318
2021 Du J, Agatemor C, Saeui CT, Bhattacharya R, Jia X, Yarema KJ. Glycoengineering Human Neural and Adipose Stem Cells with Novel Thiol-Modified -Acetylmannosamine (ManNAc) Analogs. Cells. 10. PMID 33673061 DOI: 10.3390/cells10020377  0.713
2020 Stabach PR, Zimmerman K, Adame A, Kavanagh D, Saeui CT, Agatemor C, Gray S, Cao W, De La Cruz EM, Yarema KJ, Braddock DT. Improving the Pharmacodynamics and In Vivo Activity of ENPP1-Fc Through Protein and Glycosylation Engineering. Clinical and Translational Science. PMID 33064927 DOI: 10.1111/cts.12887  0.673
2020 Saeui CT, Cho KC, Dharmarha V, Nairn AV, Galizzi M, Shah SR, Gowda P, Park M, Austin M, Clarke A, Cai E, Buettner MJ, Ariss R, Moremen KW, Zhang H, ... Yarema KJ, et al. Cell Line-, Protein-, and Sialoglycosite-Specific Control of Flux-Based Sialylation in Human Breast Cells: Implications for Cancer Progression. Frontiers in Chemistry. 8: 13. PMID 32117864 DOI: 10.3389/Fchem.2020.00013  0.377
2019 Agatemor C, Buettner MJ, Ariss R, Muthiah K, Saeui CT, Yarema KJ. Exploiting metabolic glycoengineering to advance healthcare. Nature Reviews. Chemistry. 3: 605-620. PMID 31777760 DOI: 10.1038/s41570-019-0126-y  0.686
2018 Saeui CT, Nairn AV, Galizzi M, Douville C, Gowda P, Park M, Dharmarha V, Shah SR, Clarke A, Austin M, Moremen KW, Yarema KJ. Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes. Plos One. 13: e0195812. PMID 29847599 DOI: 10.1371/Journal.Pone.0195812  0.364
2017 Kim H, Shin K, Park OK, Choi D, Kim HD, Baik S, Lee SH, Kwon SH, Yarema KJ, Hong J, Hyeon T, Hwang NS. General and Facile Coating of Single Cells via Mild Reduction. Journal of the American Chemical Society. PMID 29281277 DOI: 10.1021/Jacs.7B08440  0.324
2017 Yin B, Wang Q, Chung CY, Bhattacharya R, Ren X, Tang J, Yarema KJ, Betenbaugh MJ. A novel sugar analog enhances sialic acid production and biotherapeutic sialylation in CHO cells. Biotechnology and Bioengineering. PMID 28295160 DOI: 10.1002/Bit.26291  0.33
2017 Mathew M, Tan E, Labonte JW, Shah S, Saeui CT, Liu L, Bhattacharya R, Bovonratwet P, Gray JJ, Yarema K. GLYCOENGINEERING OF ESTERASE ACTIVITY THROUGH METABOLIC FLUX-BASED MODULATION OF SIALIC ACID. Chembiochem : a European Journal of Chemical Biology. PMID 28218815 DOI: 10.1002/Cbic.201600698  0.351
2016 Saeui CT, Yarema K. Abstract LB-054: Small molecule inhibitors of the hexosamine biosynthetic pathway and the cancer O-GlcNAcome Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-054  0.349
2015 Badr HA, AlSadek DM, Mathew MP, Li CZ, Djansugurova LB, Yarema KJ, Ahmed H. Lectin staining and Western blot data showing differential sialylation of nutrient-deprived cancer cells to sialic acid supplementation. Data in Brief. 5: 481-488. PMID 26629491 DOI: 10.1016/j.dib.2015.09.043  0.345
2015 Badr HA, AlSadek DM, Mathew MP, Li CZ, Djansugurova LB, Yarema KJ, Ahmed H. Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation. Biomaterials. 70: 23-36. PMID 26295436 DOI: 10.1016/j.biomaterials.2015.08.020  0.39
2015 Tian Y, Almaraz RT, Choi CH, Li QK, Saeui C, Li D, Shah P, Bhattacharya R, Yarema KJ, Zhang H. Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells. Clinical Proteomics. 12: 11. PMID 25987888 DOI: 10.1186/s12014-015-9083-8  0.317
2013 Shah P, Yang S, Sun S, Aiyetan P, Yarema KJ, Zhang H. Mass spectrometric analysis of sialylated glycans with use of solid-phase labeling of sialic acids. Analytical Chemistry. 85: 3606-13. PMID 23445396 DOI: 10.1021/Ac3033867  0.316
2012 Mathew MP, Tan E, Shah S, Bhattacharya R, Adam Meledeo M, Huang J, Espinoza FA, Yarema KJ. Extracellular and intracellular esterase processing of SCFA-hexosamine analogs: implications for metabolic glycoengineering and drug delivery. Bioorganic & Medicinal Chemistry Letters. 22: 6929-33. PMID 23041156 DOI: 10.1016/j.bmcl.2012.09.017  0.329
2012 Almaraz RT, Tian Y, Bhattarcharya R, Tan E, Chen SH, Dallas MR, Chen L, Zhang Z, Zhang H, Konstantopoulos K, Yarema KJ. Metabolic flux increases glycoprotein sialylation: implications for cell adhesion and cancer metastasis. Molecular & Cellular Proteomics : McP. 11: M112.017558. PMID 22457533 DOI: 10.1074/Mcp.M112.017558  0.368
2012 Almaraz RT, Aich U, Khanna HS, Tan E, Bhattacharya R, Shah S, Yarema KJ. Metabolic oligosaccharide engineering with N-Acyl functionalized ManNAc analogs: cytotoxicity, metabolic flux, and glycan-display considerations. Biotechnology and Bioengineering. 109: 992-1006. PMID 22068462 DOI: 10.1002/bit.24363  0.4
2012 Almaraz RT, Mathew MP, Tan E, Yarema KJ. Metabolic oligosaccharide engineering: implications for selectin-mediated adhesion and leukocyte extravasation. Annals of Biomedical Engineering. 40: 806-15. PMID 22037949 DOI: 10.1007/s10439-011-0450-y  0.326
2012 Schnaar R, Paulson JC, Macauley MS, Nycholat C, Pfrengle F, Rademacher C, Mahan A, Dionne K, Suscovich T, Alter G, Katoh T, Kiwamoto T, Brummet M, Bochner B, Tiemeyer M, ... ... Yarema K, et al. Program and abstracts for the 2012 Joint Meeting of the Society for Glycobiology & American Society for Matrix Biology Glycobiology. 22: 1518-1650. DOI: 10.1093/Glycob/Cws127  0.751
2011 Du J, Che PL, Aich U, Tan E, Kim HJ, Sampathkumar SG, Yarema KJ. Deciphering glycan linkages involved in Jurkat cell interactions with gold-coated nanofibers via sugar-displayed thiols. Bioorganic & Medicinal Chemistry Letters. 21: 4980-4. PMID 21684742 DOI: 10.1016/j.bmcl.2011.05.044  0.767
2011 Du J, Che PL, Wang ZY, Aich U, Yarema KJ. Designing a binding interface for control of cancer cell adhesion via 3D topography and metabolic oligosaccharide engineering. Biomaterials. 32: 5427-37. PMID 21549424 DOI: 10.1016/j.biomaterials.2011.04.005  0.343
2011 Meledeo MA, Paruchuri VDP, Du J, Wang Z, Yarema KJ. Mammalian Glycan Biosynthesis: Building a Template for Biological Recognition Carbohydrate Recognition: Biological Problems, Methods, and Applications. 1-32. DOI: 10.1002/9781118017586.ch1  0.626
2010 Tan E, Almaraz RT, Khanna HS, Du J, Yarema KJ. Experimental Design Considerations for In Vitro Non-Natural Glycan Display via Metabolic Oligosaccharide Engineering. Current Protocols in Chemical Biology. 2: 171-94. PMID 23839968 DOI: 10.1002/9780470559277.ch100059  0.391
2010 Aich U, Meledeo MA, Sampathkumar SG, Fu J, Jones MB, Weier CA, Chung SY, Tang BC, Yang M, Hanes J, Yarema KJ. Development of delivery methods for carbohydrate-based drugs: controlled release of biologically-active short chain fatty acid-hexosamine analogs. Glycoconjugate Journal. 27: 445-59. PMID 20458533 DOI: 10.1007/S10719-010-9292-3  0.769
2010 Du J, Yarema KJ. Carbohydrate engineered cells for regenerative medicine. Advanced Drug Delivery Reviews. 62: 671-82. PMID 20117158 DOI: 10.1016/j.addr.2010.01.003  0.351
2009 Wang Z, Du J, Che PL, Meledeo MA, Yarema KJ. Hexosamine analogs: from metabolic glycoengineering to drug discovery Current Opinion in Chemical Biology. 13: 565-572. PMID 19747874 DOI: 10.1016/j.cbpa.2009.08.001  0.695
2009 Du J, Meledeo MA, Wang Z, Khanna HS, Paruchuri VD, Yarema KJ. Metabolic glycoengineering: sialic acid and beyond. Glycobiology. 19: 1382-401. PMID 19675091 DOI: 10.1093/glycob/cwp115  0.731
2009 Elmouelhi N, Aich U, Paruchuri VD, Meledeo MA, Campbell CT, Wang JJ, Srinivas R, Khanna HS, Yarema KJ. Hexosamine template. A platform for modulating gene expression and for sugar-based drug discovery. Journal of Medicinal Chemistry. 52: 2515-30. PMID 19326913 DOI: 10.1021/jm801661m  0.678
2009 Atukorale PU, Choi SS, Aich U, Campbell CT, Meledeo MA, Yarema KJ. Chemical Biology of Cell Surface Oligosaccharides Protein Targeting With Small Molecules: Chemical Biology Techniques and Applications. 189-222. DOI: 10.1002/9780470495018.ch10  0.694
2008 Campbell CT, Aich U, Weier CA, Wang JJ, Choi SS, Wen MM, Maisel K, Sampathkumar SG, Yarema KJ. Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogues inhibits the mobility of metastatic MDA-MB-231 breast cancer cells. Journal of Medicinal Chemistry. 51: 8135-47. PMID 19053749 DOI: 10.1021/jm800873k  0.735
2008 Kim EJ, Shin HY, Park S, Sung D, Jon S, Sampathkumar SG, Yarema KJ, Choi SY, Kim K. Electrochemically active, anti-biofouling polymer adlayers on indium-tin-oxide electrodes. Chemical Communications (Cambridge, England). 3543-5. PMID 18654707 DOI: 10.1039/b804816a  0.684
2008 Aich U, Campbell CT, Elmouelhi N, Weier CA, Sampathkumar SG, Choi SS, Yarema KJ. Regioisomeric SCFA attachment to hexosamines separates metabolic flux from cytotoxicity and MUC1 suppression. Acs Chemical Biology. 3: 230-40. PMID 18338853 DOI: 10.1021/cb7002708  0.359
2007 Daubeuf S, Aucher A, Sampathkumar SG, Preville X, Yarema KJ, Hudrisier D. Chemical labels metabolically installed into the glycoconjugates of the target cell surface can be used to track lymphocyte/target cell interplay via trogocytosis: comparisons with lipophilic dyes and biotin. Immunological Investigations. 36: 687-712. PMID 18161525 DOI: 10.1080/08820130701674596  0.75
2007 Campbell CT, Sampathkumar SG, Yarema KJ. Metabolic oligosaccharide engineering: perspectives, applications, and future directions. Molecular Biosystems. 3: 187-94. PMID 17308665 DOI: 10.1039/b614939c  0.792
2006 Sampathkumar SG, Jones MB, Yarema KJ. Metabolic expression of thiol-derivatized sialic acids on the cell surface and their quantitative estimation by flow cytometry. Nature Protocols. 1: 1840-51. PMID 17487167 DOI: 10.1038/nprot.2006.252  0.781
2006 Sampathkumar SG, Li AV, Yarema KJ. Synthesis of non-natural ManNAc analogs for the expression of thiols on cell-surface sialic acids. Nature Protocols. 1: 2377-85. PMID 17406481 DOI: 10.1038/nprot.2006.319  0.774
2006 Sampathkumar SG, Jones MB, Meledeo MA, Campbell CT, Choi SS, Hida K, Gomutputra P, Sheh A, Gilmartin T, Head SR, Yarema KJ. Targeting glycosylation pathways and the cell cycle: sugar-dependent activity of butyrate-carbohydrate cancer prodrugs. Chemistry & Biology. 13: 1265-75. PMID 17185222 DOI: 10.1016/J.Chembiol.2006.09.016  0.809
2006 Sampathkumar SG, Li A, Yarema KJ. Sialic acid and the central nervous system: perspectives on biological functions, detection, imaging methods and manipulation. Cns & Neurological Disorders Drug Targets. 5: 425-40. PMID 16918394  0.719
2006 Sampathkumar SG, Li AV, Jones MB, Sun Z, Yarema KJ. Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology. Nature Chemical Biology. 2: 149-52. PMID 16474386 DOI: 10.1038/nchembio770  0.783
2006 Loo Y, Sampathkumar S, Atukorale PU, Yarema KJ, Leong KW. 356. Engineering of Cell Surface Sialic Acids for Polymeric Gene Delivery Molecular Therapy. 13: S135-S136. DOI: 10.1016/J.Ymthe.2006.08.414  0.402
2005 Salama I, Hinderlich S, Shlomai Z, Eisenberg I, Krause S, Yarema K, Argov Z, Lochmuller H, Reutter W, Dabby R, Sadeh M, Ben-Bassat H, Mitrani-Rosenbaum S. No overall hyposialylation in hereditary inclusion body myopathy myoblasts carrying the homozygous M712T GNE mutation. Biochemical and Biophysical Research Communications. 328: 221-6. PMID 15670773 DOI: 10.1016/J.Bbrc.2004.12.157  0.312
2005 Sampathkumar SG, Yarema KJ. Targeting cancer cells with dendrimers. Chemistry & Biology. 12: 5-6. PMID 15664507 DOI: 10.1016/j.chembiol.2004.12.007  0.719
2004 Kim EJ, Jones MB, Rhee JK, Sampathkumar SG, Yarema KJ. Establishment of N-acetylmannosamine (ManNAc) analogue-resistant cell lines as improved hosts for sialic acid engineering applications. Biotechnology Progress. 20: 1674-82. PMID 15575698 DOI: 10.1021/Bp049841Q  0.763
2004 Murrell MP, Yarema KJ, Levchenko A. The systems biology of glycosylation. Chembiochem : a European Journal of Chemical Biology. 5: 1334-47. PMID 15457533 DOI: 10.1002/Cbic.200400143  0.675
2004 Kim EJ, Sampathkumar SG, Jones MB, Rhee JK, Baskaran G, Goon S, Yarema KJ. Characterization of the metabolic flux and apoptotic effects of O-hydroxyl- and N-acyl-modified N-acetylmannosamine analogs in Jurkat cells. The Journal of Biological Chemistry. 279: 18342-52. PMID 14966124 DOI: 10.1074/Jbc.M400205200  0.803
2004 Jones MB, Teng H, Rhee JK, Lahar N, Baskaran G, Yarema KJ. Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogues to sialic acids. Biotechnology and Bioengineering. 85: 394-405. PMID 14755557 DOI: 10.1002/bit.10901  0.428
2003 Viswanathan K, Lawrence S, Hinderlich S, Yarema KJ, Lee YC, Betenbaugh MJ. Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome them. Biochemistry. 42: 15215-25. PMID 14690432 DOI: 10.1021/Bi034994S  0.376
2003 Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR. GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism. The Journal of Biological Chemistry. 278: 8035-42. PMID 12499362 DOI: 10.1074/Jbc.M212127200  0.803
2002 Yarema KJ. New directions in carbohydrate engineering: a metabolic substrate-based approach to modify the cell surface display of sialic acids. Biotechniques. 31: 384-93. PMID 11515375 DOI: 10.2144/01312RV02  0.391
2001 Jacobs CL, Goon S, Yarema KJ, Hinderlich S, Hang HC, Chai DH, Bertozzi CR. Substrate specificity of the sialic acid biosynthetic pathway. Biochemistry. 40: 12864-74. PMID 11669623 DOI: 10.1021/Bi010862S  0.8
2001 Yarema KJ, Bertozzi CR. Characterizing glycosylation pathways. Genome Biology. 2: REVIEWS0004. PMID 11387039 DOI: 10.1186/Gb-2001-2-5-Reviews0004  0.493
2001 Yarema KJ, Goon S, Bertozzi CR. Metabolic selection of glycosylation defects in human cells. Nature Biotechnology. 19: 553-8. PMID 11385460 DOI: 10.1038/89305  0.761
2000 Jacobs CL, Yarema KJ, Mahal LK, Nauman DA, Charters NW, Bertozzi CR. Metabolic labeling of glycoproteins with chemical tags through unnatural sialic acid biosynthesis. Methods in Enzymology. 327: 260-75. PMID 11044989 DOI: 10.1016/S0076-6879(00)27282-0  0.761
1999 Lemieux GA, Yarema KJ, Jacobs CL, Bertozzi CR. Exploiting differences in sialoside expression for selective targeting of MRI contrast reagents Journal of the American Chemical Society. 121: 4278-4279. DOI: 10.1021/Ja984228M  0.735
1998 Yarema KJ, Mahal LK, Bruehl RE, Rodriguez EC, Bertozzi CR. Metabolic delivery of ketone groups to sialic acid residues. Application To cell surface glycoform engineering. The Journal of Biological Chemistry. 273: 31168-79. PMID 9813021 DOI: 10.1074/Jbc.273.47.31168  0.747
1998 Yarema KJ, Bertozzi CR. Chemical approaches to glycobiology and emerging carbohydrate-based therapeutic agents. Current Opinion in Chemical Biology. 2: 49-61. PMID 9667919 DOI: 10.1016/S1367-5931(98)80035-5  0.515
1997 Mahal LK, Yarema KJ, Bertozzi CR. Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis. Science (New York, N.Y.). 276: 1125-8. PMID 9173543 DOI: 10.1126/Science.276.5315.1125  0.727
1996 Rink SM, Yarema KJ, Solomon MS, Paige LA, Tadayoni-Rebek BM, Essigmann JM, Croy RG. Synthesis and biological activity of DNA damaging agents that form decoy binding sites for the estrogen receptor. Proceedings of the National Academy of Sciences of the United States of America. 93: 15063-8. PMID 8986764 DOI: 10.1073/Pnas.93.26.15063  0.533
1996 Moggs JG, Yarema KJ, Essigmann JM, Wood RD. Analysis of incision sites produced by human cell extracts and purified proteins during nucleotide excision repair of a 1,3-intrastrand d(GpTpG)-cisplatin adduct. The Journal of Biological Chemistry. 271: 7177-86. PMID 8636155 DOI: 10.1074/Jbc.271.12.7177  0.5
1995 Yarema KJ, Lippard SJ, Essigmann JM. Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II). Nucleic Acids Research. 23: 4066-72. PMID 7479066 DOI: 10.1093/Nar/23.20.4066  0.464
1995 Yarema KJ, Essigmann JM. Evaluation of the Genetic Effects of Defined DNA Lesions Formed by DNA-Damaging Agents Methods. 7: 133-146. DOI: 10.1006/Meth.1995.1020  0.469
1994 Yarema KJ, Wilson JM, Lippard SJ, Essigmann JM. Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs. Journal of Molecular Biology. 236: 1034-48. PMID 8120885 DOI: 10.1016/0022-2836(94)90010-8  0.492
1993 Bradley LJ, Yarema KJ, Lippard SJ, Essigmann JM. Mutagenicity and genotoxicity of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II). Biochemistry. 32: 982-8. PMID 8422401 DOI: 10.1021/Bi00054A031  0.481
1992 Szymkowski DE, Yarema K, Essigmann JM, Lippard SJ, Wood RD. An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts. Proceedings of the National Academy of Sciences of the United States of America. 89: 10772-6. PMID 1438274 DOI: 10.1073/Pnas.89.22.10772  0.559
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