| Year |
Citation |
Score |
| 2024 |
Cannon AC, Budagyan K, Uribe-Alvarez C, Kurimchak AM, Araiza-Olivera D, Cai KQ, Peri S, Zhou Y, Duncan JS, Chernoff J. Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints. Oncogene. PMID 38243078 DOI: 10.1038/s41388-024-02947-z |
0.366 |
|
| 2023 |
Benton D, Chernoff J. RHOA drivers take alternate routes in gastric cancer. Science Signaling. 16: eadk9171. PMID 38113334 DOI: 10.1126/scisignal.adk9171 |
0.572 |
|
| 2023 |
Villamar-Cruz O, Loza-Mejía MA, Vivar-Sierra A, Saldivar-Cerón HI, Patiño-López G, Olguín JE, Terrazas LI, Armas-López L, Ávila-Moreno F, Saha S, Chernoff J, Camacho-Arroyo I, Arias-Romero LE. A PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway. Molecular and Cellular Biology. 1-19. PMID 38014992 DOI: 10.1080/10985549.2023.2273193 |
0.403 |
|
| 2023 |
Wang Y, Risteski P, Yang Y, Chen H, Droby G, Walens A, Jayaprakash D, Troester M, Herring L, Chernoff J, Tolić IM, Bowser J, Vaziri C. The TRIM69-MST2 signaling axis regulates centrosome dynamics and chromosome segregation. Nucleic Acids Research. PMID 37739411 DOI: 10.1093/nar/gkad766 |
0.339 |
|
| 2023 |
Benton D, Chernoff J. TRIMming away colon cancer: TRIM21-mediated ubiquitination as an activator of the Hippo tumor suppressor pathway. Cell Chemical Biology. 30: 699-701. PMID 37478825 DOI: 10.1016/j.chembiol.2023.06.023 |
0.659 |
|
| 2023 |
Cannon AC, Budagyan K, Uribe-Alvarez C, Kurimchak AM, Araiza-Olivera D, Cai KQ, Peri S, Zhou Y, Duncan JS, Chernoff J. Unique vulnerability of -mutant melanoma to combined inhibition of CDK9 and immune checkpoints. Biorxiv : the Preprint Server For Biology. PMID 37425776 DOI: 10.1101/2023.06.27.546707 |
0.8 |
|
| 2023 |
Somanath PR, Chernoff J, Cummings BS, Prasad SM, Homan HD. Targeting P21-Activated Kinase-1 for Metastatic Prostate Cancer. Cancers. 15. PMID 37190165 DOI: 10.3390/cancers15082236 |
0.308 |
|
| 2022 |
Chow HY, Karchugina S, Groendyke BJ, Toenjes S, Hatcher J, Donovan KA, Fischer ES, Abalakov G, Faezov B, Dunbrack R, Gray NS, Chernoff J. Development and Utility of a PAK1-Selective Degrader. Journal of Medicinal Chemistry. 65: 15627-15641. PMID 36416208 DOI: 10.1021/acs.jmedchem.2c00756 |
0.807 |
|
| 2022 |
Saldivar-Cerón HI, Villamar-Cruz O, Wells CM, Oguz I, Spaggiari F, Chernoff J, Patiño-López G, Huerta-Yepez S, Montecillo-Aguado M, Rivera-Pazos CM, Loza-Mejía MA, Vivar-Sierra A, Briseño-Díaz P, Zentella-Dehesa A, Leon-Del-Rio A, et al. p21-Activated Kinase 1 Promotes Breast Tumorigenesis Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II. Frontiers in Cell and Developmental Biology. 9: 759259. PMID 35111748 DOI: 10.3389/fcell.2021.759259 |
0.368 |
|
| 2022 |
Sementino E, Kadariya Y, Cheung M, Menges CW, Tan Y, Kukuyan AM, Shrestha U, Karchugina S, Cai KQ, Peri S, Duncan JS, Chernoff J, Testa JR. Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling. Molecular Cancer Research : McR. PMID 35082167 DOI: 10.1158/1541-7786.MCR-21-0837 |
0.837 |
|
| 2021 |
Hawley E, Gehlhausen J, Karchugina S, Chow HY, Araiza-Olivera D, Radu M, Smith A, Burks C, Jiang L, Li X, Bessler W, Masters A, Edwards D, Burgin C, Jones D, ... ... Chernoff J, et al. PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2). Human Molecular Genetics. PMID 34075397 DOI: 10.1093/hmg/ddab106 |
0.825 |
|
| 2021 |
Budagyan K, Chernoff J. A Facile Method to Engineer Mutant Kras Alleles in an Isogenic Cell Background. Methods in Molecular Biology (Clifton, N.J.). 2262: 323-334. PMID 33977487 DOI: 10.1007/978-1-0716-1190-6_20 |
0.785 |
|
| 2021 |
Karchugina S, Benton D, Chernoff J. Regulation of MST complexes and activity via SARAH domain modifications. Biochemical Society Transactions. 49: 675-683. PMID 33860801 DOI: 10.1042/BST20200559 |
0.787 |
|
| 2020 |
Cannon AC, Uribe-Alvarez C, Chernoff J. RAC1 as a Therapeutic Target in Malignant Melanoma. Trends in Cancer. 6: 478-488. PMID 32460002 DOI: 10.1016/J.Trecan.2020.02.021 |
0.812 |
|
| 2020 |
Kurimchak AM, Herrera-Montávez C, Brown J, Johnson KJ, Sodi V, Srivastava N, Kumar V, Deihimi S, O'Brien S, Peri S, Mantia-Smaldone GM, Jain A, Winters RM, Cai KQ, Chernoff J, et al. Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma. Science Signaling. 13. PMID 32071169 DOI: 10.1126/Scisignal.Aax8238 |
0.485 |
|
| 2020 |
Uribe-Alvarez C, Guerrero-Rodríguez SL, Rhodes J, Cannon A, Chernoff J, Araiza-Olivera D. Targeting effector pathways in RAC1-driven malignant melanoma. Small Gtpases. 1-9. PMID 32043900 DOI: 10.1080/21541248.2020.1728469 |
0.84 |
|
| 2020 |
Benton D, Chernoff J. A New Rho(d) Map to Diffuse Gastric Cancer. Cancer Discovery. 10: 182-184. PMID 32024682 DOI: 10.1158/2159-8290.Cd-19-1327 |
0.627 |
|
| 2020 |
Srivastava N, Kurimchak A, Montavez C, Chernoff J, Duncan J. Abstract A34: Defining KRAS mutation-specific kinome signatures and vulnerabilities in colorectal cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-A34 |
0.392 |
|
| 2020 |
Cannon AC, Chernoff J. Abstract 2587: RAC1P29Sexpression in melanocytes is associated with increased DNA damage and altered cell cycle progression Immunology. DOI: 10.1158/1538-7445.Am2020-2587 |
0.765 |
|
| 2019 |
Shen YC, Arellano-Garcia C, Menjivar RE, Jewett EM, Dohle W, Karchugina S, Chernoff J, Potter BVL, Barald KF. Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2). Bmc Pharmacology & Toxicology. 20: 67. PMID 31730023 DOI: 10.1186/S40360-019-0369-8 |
0.804 |
|
| 2019 |
Sannai M, Doneddu V, Giri V, Seeholzer S, Nicolas E, Yip SC, Bassi MR, Mancuso P, Cortellino S, Cigliano A, Lurie R, Ding H, Chernoff J, Sobol RW, Yen TJ, et al. Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1. Dna Repair. 82: 102687. PMID 31476572 DOI: 10.1016/J.Dnarep.2019.102687 |
0.329 |
|
| 2019 |
Korobeynikov V, Borakove M, Feng Y, Wuest WM, Koval AB, Nikonova AS, Serebriiskii I, Chernoff J, Borges VF, Golemis EA, Shagisultanova E. Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer. Breast Cancer Research and Treatment. PMID 31254157 DOI: 10.1007/S10549-019-05329-2 |
0.468 |
|
| 2019 |
Kurimchak AM, Shelton C, Herrera-Montávez C, Duncan KE, Chernoff J, Duncan JS. Intrinsic Resistance to MEK Inhibition Through BET Protein Mediated Kinome Reprogramming in NF1-deficient Ovarian Cancer. Molecular Cancer Research : McR. PMID 31043489 DOI: 10.1158/1541-7786.Mcr-18-1332 |
0.462 |
|
| 2018 |
Lu H, Liu S, Zhang G, Wu B, Zhu Y, Frederick DT, Hu Y, Zhong W, Randell S, Sadek N, Zhang W, Chen G, Cheng C, Zeng J, Wu LW, ... ... Chernoff J, et al. Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature. PMID 30532003 DOI: 10.1038/S41586-018-0814-7 |
0.34 |
|
| 2018 |
Karchugina S, Chernoff J. Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay. Journal of Visualized Experiments : Jove. PMID 30394375 DOI: 10.3791/57755 |
0.788 |
|
| 2018 |
Chow HY, Dong B, Valencia CA, Zeng CT, Koch JN, Prudnikova TY, Chernoff J. Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer. Nature Communications. 9: 3473. PMID 30150766 DOI: 10.1038/S41467-018-05935-6 |
0.44 |
|
| 2018 |
Stepanova DS, Braun L, Chernoff J. A new concept in NF2 pharmacotherapy: targeting fatty acid synthesis. Oncoscience. 5: 126-127. PMID 30035161 DOI: 10.18632/oncoscience.417 |
0.733 |
|
| 2018 |
Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, et al. PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells. Cancer Discovery. PMID 29572236 DOI: 10.1158/2159-8290.Cd-17-1215 |
0.313 |
|
| 2018 |
Semenova G, Stepanova D, Karchugina S, Dubyk C, Deyev S, Lazar A, Chernoff J. Abstract B066: Unique roles of group I PAK isoforms in regulating MPNST cell viability Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-B066 |
0.815 |
|
| 2017 |
Zeng Y, Hahn S, Stokes J, Hoffman EA, Schmelz M, Proytcheva M, Chernoff J, Katsanis E. Pak2 regulates myeloid-derived suppressor cell development in mice. Blood Advances. 1: 1923-1933. PMID 29296839 DOI: 10.1182/Bloodadvances.2017007435 |
0.446 |
|
| 2017 |
Araiza-Olivera D, Feng Y, Semenova G, Prudnikova TY, Rhodes J, Chernoff J. Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors. Oncogene. PMID 29059171 DOI: 10.1038/Onc.2017.400 |
0.777 |
|
| 2017 |
Zeng K, Tian L, Sirek A, Shao W, Liu L, Chiang YT, Chernoff J, Ng DS, Weng J, Jin T. Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression. Journal of Molecular Cell Biology. PMID 28992163 DOI: 10.1093/Jmcb/Mjx031 |
0.333 |
|
| 2017 |
Lu H, Liu S, Zhang G, Bin Wu, Zhu Y, Frederick DT, Hu Y, Zhong W, Randell S, Sadek N, Zhang W, Chen G, Cheng C, Zeng J, Wu LW, ... ... Chernoff J, et al. PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature. PMID 28953887 DOI: 10.1038/Nature24040 |
0.357 |
|
| 2017 |
Stepanova DS, Semenova G, Kuo YM, Andrews AJ, Ammoun S, Hanemann CO, Chernoff J. An essential role for the tumor suppressor Merlin in regulating fatty acid synthesis. Cancer Research. PMID 28729415 DOI: 10.1158/0008-5472.Can-16-2834 |
0.803 |
|
| 2017 |
Radu M, Chernoff J. Recent advances in methods to assess the activity of the kinome. F1000research. 6: 1004. PMID 28713564 DOI: 10.12688/F1000Research.10962.1 |
0.463 |
|
| 2017 |
Semenova G, Stepanova DS, Dubyk C, Handorf E, Deyev SM, Lazar AJ, Chernoff J. Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis. Oncogene. PMID 28534510 DOI: 10.1038/Onc.2017.143 |
0.83 |
|
| 2017 |
Semenova G, Chernoff J. Targeting PAK1. Biochemical Society Transactions. 45: 79-88. PMID 28202661 DOI: 10.1042/BST20160134 |
0.723 |
|
| 2017 |
Semenova G, Stepanova D, Deyev SM, Chernoff J. Medium throughput biochemical compound screening identifies novel agents for pharmacotherapy of neurofibromatosis type I. Biochimie. PMID 28065690 DOI: 10.1016/J.Biochi.2017.01.001 |
0.787 |
|
| 2016 |
Joseph GA, Lu M, Radu M, Lee JK, Burden SJ, Chernoff J, Krauss RS. Group I Paks promote skeletal myoblast differentiation in vivo and in vitro. Molecular and Cellular Biology. PMID 27920252 DOI: 10.1128/Mcb.00222-16 |
0.401 |
|
| 2016 |
Villamar Cruz O, Prudnikova TY, Araiza-Olivera D, Perez-Plasencia C, Johnson N, Bernhardy AJ, Slifker M, Renner C, Chernoff J, Arias-Romero LE. Reduced PAK1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition. Oncotarget. PMID 27740936 DOI: 10.18632/Oncotarget.12576 |
0.456 |
|
| 2016 |
Araiza-Olivera D, Chernoff J. HRAs helps hippo heterodimerize to evade tumor suppression. Small Gtpases. 0. PMID 27560370 DOI: 10.1080/21541248.2016.1228794 |
0.473 |
|
| 2016 |
Kurimchak AM, Shelton C, Duncan KE, Johnson KJ, Brown J, O'Brien S, Gabbasov R, Fink LS, Li Y, Lounsbury N, Abou-Gharbia M, Childers WE, Connolly DC, Chernoff J, Peterson JR, et al. Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer. Cell Reports. PMID 27452461 DOI: 10.1016/J.Celrep.2016.06.091 |
0.415 |
|
| 2016 |
Prudnikova TY, Chernoff J. The Group I Pak inhibitor Frax-1036 sensitizes 11q13-amplified ovarian cancer cells to the cytotoxic effects of Rottlerin. Small Gtpases. 0. PMID 27427770 DOI: 10.1080/21541248.2016.1213089 |
0.465 |
|
| 2016 |
Rawat SJ, Araiza-Olivera D, Arias-Romero LE, Villamar-Cruz O, Prudnikova TY, Roder H, Chernoff J. H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization. Current Biology : Cb. PMID 27238285 DOI: 10.1016/J.Cub.2016.04.027 |
0.809 |
|
| 2016 |
Reddy PN, Radu M, Xu K, Wood J, Harris CE, Chernoff J, Williams DA. p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with β-Pix. Blood. 127: 1967-75. PMID 26932803 DOI: 10.1182/Blood-2016-01-693572 |
0.456 |
|
| 2016 |
Prudnikova TY, Villamar-Cruz O, Rawat SJ, Cai KQ, Chernoff J. Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells. Oncogene. 35: 2178-85. PMID 26257058 DOI: 10.1038/Onc.2015.278 |
0.805 |
|
| 2016 |
Zeng Y, Hahn S, Stokes J, Hoffman E, Chernoff J, Katsanis E. Pak2 Regulates MDSC Development and Function Blood. 128: 705-705. DOI: 10.1182/Blood.V128.22.705.705 |
0.438 |
|
| 2016 |
Prudnikova T, Chernoff J. Abstract LB-011: PAK1 inhibitor FRAX1036 sensitizes ovarian cancer cells with amplified 11q13 to cytotoxic effect of rottlerin Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-011 |
0.332 |
|
| 2016 |
Araiza-Olivera D, Chernoff J. Abstract LB-001: Functional role of Pak1/Erk signaling in Rac1-related diseases Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-001 |
0.493 |
|
| 2016 |
Villamar-Cruz O, Prudnikova T, Johnson N, Chernoff J, Romero LEA. Abstract 1876: Reduced Pak1 activity sensitizes FA/BRCA-proficient breast cancer cells to PARP inhibition Cancer Research. 76: 1876-1876. DOI: 10.1158/1538-7445.Am2016-1876 |
0.454 |
|
| 2016 |
Shagisultanova E, Korobeynikov V, Nikonova A, Chernoff J, Borges V, Golemis E. Abstract 1242: Combination of p21-activated kinase 1 (PAK1) inhibitor FRAX1036 and Aurora-A inhibitor alisertib is effective in hormone receptor-positive breast cancer Cancer Research. 76: 1242-1242. DOI: 10.1158/1538-7445.Am2016-1242 |
0.428 |
|
| 2016 |
Prudnikova TY, Villamar-Cruz O, Rawat SJ, Cai KQ, Chernoff J. Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells Oncogene. 35: 2178-2185. DOI: 10.1038/onc.2015.278 |
0.795 |
|
| 2015 |
Radu M, Lyle K, Hoeflich KP, Villamar-Cruz O, Koeppen H, Chernoff J. p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway. Molecular and Cellular Biology. 35: 3990-4005. PMID 26391956 DOI: 10.1128/Mcb.00630-15 |
0.396 |
|
| 2015 |
Pandolfi A, Stanley RF, Yu Y, Bartholdy B, Pendurti G, Gritsman K, Boultwood J, Chernoff J, Verma A, Steidl U. PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome. Blood. PMID 26170031 DOI: 10.1182/Blood-2014-12-618801 |
0.419 |
|
| 2015 |
O'Hagan KL, Choi J, Pryshchep O, Chernoff J, Phee H. Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance. Journal of Immunology (Baltimore, Md. : 1950). 195: 1564-77. PMID 26157175 DOI: 10.4049/Jimmunol.1500843 |
0.414 |
|
| 2015 |
Singh NK, Kotla S, Dyukova E, Traylor JG, Orr AW, Chernoff J, Marion TN, Rao GN. Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. Nature Communications. 6: 7450. PMID 26104863 DOI: 10.1038/Ncomms8450 |
0.331 |
|
| 2015 |
Ong CC, Gierke S, Pitt C, Sagolla M, Cheng CK, Zhou W, Jubb AM, Strickland L, Schmidt M, Duron SG, Campbell DA, Zheng W, Dehdashti S, Shen M, Yang N, ... ... Chernoff J, et al. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents. Breast Cancer Research : Bcr. 17: 59. PMID 25902869 DOI: 10.1186/S13058-015-0564-5 |
0.449 |
|
| 2015 |
Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J. Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. Blood. 125: 2995-3005. PMID 25824689 DOI: 10.1182/Blood-2014-10-604504 |
0.799 |
|
| 2015 |
Rawat SJ, Chernoff J. Regulation of mammalian Ste20 (Mst) kinases. Trends in Biochemical Sciences. 40: 149-56. PMID 25665457 DOI: 10.1016/J.Tibs.2015.01.001 |
0.805 |
|
| 2015 |
Chow HY, Dong B, Duron SG, Campbell DA, Ong CC, Hoeflich KP, Chang LS, Welling DB, Yang ZJ, Chernoff J. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 6: 1981-94. PMID 25596744 DOI: 10.18632/Oncotarget.2810 |
0.483 |
|
| 2015 |
Zeng Y, Broxmeyer HE, Staser K, Chitteti BR, Park SJ, Hahn S, Cooper S, Sun Z, Jiang L, Yang X, Yuan J, Kosoff R, Sandusky G, Srour EF, Chernoff J, et al. Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation. Stem Cells (Dayton, Ohio). 33: 1630-41. PMID 25586960 DOI: 10.1002/Stem.1951 |
0.777 |
|
| 2015 |
Prudnikova TY, Rawat SJ, Chernoff J. Molecular pathways: targeting the kinase effectors of RHO-family GTPases. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 24-9. PMID 25336694 DOI: 10.1158/1078-0432.Ccr-14-0827 |
0.818 |
|
| 2015 |
Badolia R, Manne BK, Dangelmaier C, Chernoff J, Kunapuli SP. Gq-mediated Akt translocation to the membrane: a novel PIP3-independent mechanism in platelets. Blood. 125: 175-84. PMID 25331114 DOI: 10.1182/Blood-2014-05-576306 |
0.33 |
|
| 2015 |
Kosoff RE, Chernoff J. Abstract A40: Megakaryocyte endomitosis requires Pak2 to regulate actin and microtubule networks. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-A40 |
0.366 |
|
| 2015 |
Semenova G, Chernoff J. Abstract 1026: Role of Group I Paks in MPNST cell proliferation, migration and invasion Cancer Research. 75: 1026-1026. DOI: 10.1158/1538-7445.Am2015-1026 |
0.784 |
|
| 2015 |
Prudnikova TY, Rawat SJ, Chernoff J. Molecular pathways: Targeting the kinase effectors of RHO-family GTPases Clinical Cancer Research. 21: 24-29. DOI: 10.1158/1078-0432.CCR-14-0827 |
0.808 |
|
| 2015 |
Rawat SJ, Chernoff J. Regulation of mammalian Ste20 (Mst) kinases Trends in Biochemical Sciences. 40: 149-156. DOI: 10.1016/j.tibs.2015.01.001 |
0.795 |
|
| 2015 |
Stepanova DS, Chernoff J, Shimanovskiy NL. Search for Chemical Compounds for Pharmacotherapy of Neurofibromatosis Type 2 Pharmaceutical Chemistry Journal. 48: 777-782. DOI: 10.1007/S11094-015-1194-Z |
0.762 |
|
| 2014 |
Elsherif L, Ozler M, Zayed MA, Shen JH, Chernoff J, Faber JE, Parise LV. Potential compensation among group I PAK members in hindlimb ischemia and wound healing. Plos One. 9: e112239. PMID 25379771 DOI: 10.1371/Journal.Pone.0112239 |
0.36 |
|
| 2014 |
Baker NM, Yee Chow H, Chernoff J, Der CJ. Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 4740-6. PMID 25225063 DOI: 10.1158/1078-0432.Ccr-13-1727 |
0.429 |
|
| 2014 |
Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A. Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation. Elife. 3: e02270. PMID 24843022 DOI: 10.7554/Elife.02270 |
0.8 |
|
| 2014 |
Kelly ML, Astsaturov A, Rhodes J, Chernoff J. A Pak1/Erk signaling module acts through Gata6 to regulate cardiovascular development in zebrafish. Developmental Cell. 29: 350-9. PMID 24823378 DOI: 10.1016/J.Devcel.2014.04.003 |
0.719 |
|
| 2014 |
Chiang YT, Ip W, Shao W, Song ZE, Chernoff J, Jin T. Activation of cAMP signaling attenuates impaired hepatic glucose disposal in aged male p21-activated protein kinase-1 knockout mice. Endocrinology. 155: 2122-32. PMID 24684301 DOI: 10.1210/En.2013-1743 |
0.339 |
|
| 2014 |
Radu M, Semenova G, Kosoff R, Chernoff J. PAK signalling during the development and progression of cancer. Nature Reviews. Cancer. 14: 13-25. PMID 24505617 DOI: 10.1038/Nrc3645 |
0.822 |
|
| 2014 |
Saha S, Chernoff J. Analysis of PTP1B sumoylation. Methods (San Diego, Calif.). 65: 201-6. PMID 24076082 DOI: 10.1016/J.Ymeth.2013.09.012 |
0.375 |
|
| 2014 |
Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A. Author response: Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation Elife. DOI: 10.7554/Elife.02270.017 |
0.761 |
|
| 2014 |
Kosoff RE, Chernoff J. Abstract A15: Megakaryocyte differentiation is regulated by p21-activated kinase 2 Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-A15 |
0.412 |
|
| 2014 |
Arias-Romero LE, Villamar-Cruz O, Chernoff J. Abstract A02: Pak1 kinase inhibition sensitizes 11q13 amplified breast cancer cells to platinum based chemotherapy via downregulation of Fanconi anemia genes Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-A02 |
0.419 |
|
| 2013 |
Rudolph J, Crawford JJ, Hoeflich KP, Chernoff J. p21-activated kinase inhibitors. The Enzymes. 34: 157-80. PMID 25034104 DOI: 10.1016/B978-0-12-420146-0.00007-X |
0.475 |
|
| 2013 |
Itakura A, Aslan JE, Kusanto BT, Phillips KG, Porter JE, Newton PK, Nan X, Insall RH, Chernoff J, McCarty OJ. p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. Plos One. 8: e73063. PMID 24019894 DOI: 10.1371/Journal.Pone.0073063 |
0.426 |
|
| 2013 |
Licciulli S, Maksimoska J, Zhou C, Troutman S, Kota S, Liu Q, Duron S, Campbell D, Chernoff J, Field J, Marmorstein R, Kissil JL. FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. The Journal of Biological Chemistry. 288: 29105-14. PMID 23960073 DOI: 10.1074/Jbc.M113.510933 |
0.512 |
|
| 2013 |
Arias-Romero LE, Chernoff J. Targeting Cdc42 in cancer. Expert Opinion On Therapeutic Targets. 17: 1263-73. PMID 23957315 DOI: 10.1517/14728222.2013.828037 |
0.371 |
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| 2013 |
Aslan JE, Baker SM, Loren CP, Haley KM, Itakura A, Pang J, Greenberg DL, David LL, Manser E, Chernoff J, McCarty OJ. The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. American Journal of Physiology. Cell Physiology. 305: C519-28. PMID 23784547 DOI: 10.1152/Ajpcell.00418.2012 |
0.374 |
|
| 2013 |
Radu M, Rawat SJ, Beeser A, Iliuk A, Tao WA, Chernoff J. ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. The Journal of Biological Chemistry. 288: 21117-25. PMID 23760270 DOI: 10.1074/Jbc.M113.459719 |
0.813 |
|
| 2013 |
Kelly ML, Astsaturov A, Chernoff J. Role of p21-activated kinases in cardiovascular development and function. Cellular and Molecular Life Sciences : Cmls. 70: 4223-8. PMID 23640572 DOI: 10.1007/S00018-013-1347-8 |
0.694 |
|
| 2013 |
Aslan JE, Itakura A, Haley KM, Tormoen GW, Loren CP, Baker SM, Pang J, Chernoff J, McCarty OJ. p21 activated kinase signaling coordinates glycoprotein receptor VI-mediated platelet aggregation, lamellipodia formation, and aggregate stability under shear. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1544-51. PMID 23640496 DOI: 10.1161/Atvbaha.112.301165 |
0.366 |
|
| 2013 |
Arias-Romero LE, Villamar-Cruz O, Huang M, Hoeflich KP, Chernoff J. Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells. Cancer Research. 73: 3671-82. PMID 23576562 DOI: 10.1158/0008-5472.Can-12-4453 |
0.4 |
|
| 2013 |
Rawat SJ, Creasy CL, Peterson JR, Chernoff J. The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein. The Journal of Biological Chemistry. 288: 8762-71. PMID 23386615 DOI: 10.1074/Jbc.M112.414524 |
0.777 |
|
| 2013 |
Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, Harris CE, Mathieu R, Lane SW, Kosoff R, Milsom MD, Chernoff J, Williams DA. The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood. 121: 2474-82. PMID 23335370 DOI: 10.1182/Blood-2012-10-460709 |
0.824 |
|
| 2013 |
Huynh N, Yim M, Chernoff J, Shulkes A, Baldwin GS, He H. p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways American Journal of Physiology - Gastrointestinal and Liver Physiology. 304: G561-G567. PMID 23306081 DOI: 10.1152/Ajpgi.00218.2012 |
0.466 |
|
| 2013 |
Kosoff R, Chow HY, Radu M, Chernoff J. Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity. The Journal of Biological Chemistry. 288: 974-83. PMID 23204526 DOI: 10.1074/Jbc.M112.422295 |
0.823 |
|
| 2013 |
Chiang YA, Shao W, Xu XX, Chernoff J, Jin T. P21-activated protein kinase 1 (Pak1) mediates the cross talk between insulin and β-catenin on proglucagon gene expression and its ablation affects glucose homeostasis in male C57BL/6 mice. Endocrinology. 154: 77-88. PMID 23183186 DOI: 10.1210/En.2012-1781 |
0.357 |
|
| 2013 |
Reddy PN, Wood J, Harris CE, Xu K, McGuinness M, Radu M, Kosoff R, Chernoff J, Williams DA. Kinase Activity Of Pak2, An Effector Of Rac/CDC42 and Its Interaction With β-PIX Is Required For Murine Hematopoietic Stem Cell Shape, F-Actin Formation, Directional Migration In Vitro and For HSPC Homing To Bone Marrow In Vivo Blood. 122: 2419-2419. DOI: 10.1182/Blood.V122.21.2419.2419 |
0.791 |
|
| 2013 |
Arias-Romero LE, Villamar-Cruz O, Chernoff J. Abstract B31: Pak1 and β-catenin inhibition blocks tumor progression in ErbB2-driven breast cancer models Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Pms-B31 |
0.415 |
|
| 2012 |
Kelly ML, Chernoff J. Mouse models of PAK function. Cellular Logistics. 2: 84-88. PMID 23162740 DOI: 10.4161/Cl.21381 |
0.709 |
|
| 2012 |
Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind JS, Hoeflich KP, Chernoff J. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Research. 72: 5966-75. PMID 22983922 DOI: 10.1158/0008-5472.Can-12-2246 |
0.822 |
|
| 2012 |
Hoover WC, Zhang W, Xue Z, Gao H, Chernoff J, Clapp DW, Gunst SJ, Tepper RS. Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways. Plos One. 7: e42601. PMID 22900031 DOI: 10.1371/Journal.Pone.0042601 |
0.33 |
|
| 2012 |
Jhaveri KA, Debnath P, Chernoff J, Sanders J, Schwartz MA. The role of p21-activated kinase in the initiation of atherosclerosis. Bmc Cardiovascular Disorders. 12: 55. PMID 22824149 DOI: 10.1186/1471-2261-12-55 |
0.36 |
|
| 2012 |
Menges CW, Sementino E, Talarchek J, Xu J, Chernoff J, Peterson JR, Testa JR. Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways. Molecular Cancer Research : McR. 10: 1178-88. PMID 22798428 DOI: 10.1158/1541-7786.Mcr-12-0082 |
0.527 |
|
| 2012 |
Semenova G, Chernoff J. PKM2 enters the morpheein academy. Molecular Cell. 45: 583-4. PMID 22405271 DOI: 10.1016/J.Molcel.2012.02.014 |
0.737 |
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| 2012 |
Yip SC, Cotteret S, Chernoff J. Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin. Journal of Cell Science. 125: 310-6. PMID 22266903 DOI: 10.1242/Jcs.086256 |
0.421 |
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| 2012 |
Monasky MM, Taglieri DM, Patel BG, Chernoff J, Wolska BM, Ke Y, Solaro RJ. p21-activated kinase improves cardiac contractility during ischemia-reperfusion concomitant with changes in troponin-T and myosin light chain 2 phosphorylation. American Journal of Physiology. Heart and Circulatory Physiology. 302: H224-30. PMID 22037191 DOI: 10.1152/Ajpheart.00612.2011 |
0.369 |
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| 2012 |
Sells MA, Chernoff J. Emerging from the Pak: the p21-activated protein kinase family. Trends in Cell Biology. 7: 162-7. PMID 17708935 DOI: 10.1016/S0962-8924(97)01003-9 |
0.425 |
|
| 2012 |
Itakura A, Aslan JE, Kusanto BT, Phillips KG, Insall RH, Chernoff J, McCarty OJ. p21-Activated Kinases Regulate Directional Migration and Cytoskeletal Organization in Human Neutrophils Blood. 120: 834-834. DOI: 10.1182/Blood.V120.21.834.834 |
0.4 |
|
| 2012 |
Haley KM, Aslan JE, Tormoen GW, Baker SM, Loren CP, Chernoff J, McCarty OJ. The PAK Signaling System Links Rho Gtpase Activation to Platelet Lamellopodia Formation, Aggregation and Aggregate Stability Under Shear Blood. 120: 1060-1060. DOI: 10.1182/Blood.V120.21.1060.1060 |
0.308 |
|
| 2012 |
Romero LEA, Cruz OV, Chernoff J. Abstract 4865: Pak1 links the Wnt/β-catenin pathway to ErbB2 signaling in breast cancer cells Cancer Research. 72: 4865-4865. DOI: 10.1158/1538-7445.Am2012-4865 |
0.444 |
|
| 2011 |
Taglieri DM, Monasky MM, Knezevic I, Sheehan KA, Lei M, Wang X, Chernoff J, Wolska BM, Ke Y, Solaro RJ. Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A. Journal of Molecular and Cellular Cardiology. 51: 988-96. PMID 21971074 DOI: 10.1016/J.Yjmcc.2011.09.016 |
0.308 |
|
| 2011 |
Wang Z, Oh E, Clapp DW, Chernoff J, Thurmond DC. Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. The Journal of Biological Chemistry. 286: 41359-67. PMID 21969371 DOI: 10.1074/Jbc.M111.291500 |
0.409 |
|
| 2011 |
Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Developmental Cell. 21: 722-34. PMID 21924960 DOI: 10.1016/J.Devcel.2011.07.008 |
0.341 |
|
| 2011 |
Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith-Garvin JE, Okumura M, Starosvetsky E, Kosoff R, Libman E, Koretzky G, Kambayashi T, Urlaub H, Wienands J, Chernoff J, et al. Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells Embo Journal. 30: 3160-3172. PMID 21725281 DOI: 10.1038/Emboj.2011.213 |
0.799 |
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| 2011 |
Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM. Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. The Journal of Cell Biology. 193: 1289-303. PMID 21708980 DOI: 10.1083/Jcb.201010059 |
0.367 |
|
| 2011 |
Shepelev MV, Chernoff J, Korobko IV. Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation. Small Gtpases. 2: 17-26. PMID 21686277 DOI: 10.4161/Sgtp.2.1.15229 |
0.399 |
|
| 2011 |
De la Mota-Peynado A, Chernoff J, Beeser A. Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. The Journal of Biological Chemistry. 286: 13603-11. PMID 21317288 DOI: 10.1074/Jbc.M110.181743 |
0.518 |
|
| 2011 |
Huson SM, Acosta MT, Belzberg AJ, Bernards A, Chernoff J, Cichowski K, Gareth Evans D, Ferner RE, Giovannini M, Korf BR, Listernick R, North KN, Packer RJ, Parada LF, Peltonen J, et al. Back to the future: proceedings from the 2010 NF Conference. American Journal of Medical Genetics. Part A. 155: 307-21. PMID 21271647 DOI: 10.1002/Ajmg.A.33804 |
0.319 |
|
| 2011 |
Kelly ML, Chernoff J. Getting smart about p21-activated kinases. Molecular and Cellular Biology. 31: 386-7. PMID 21115726 DOI: 10.1128/Mcb.01267-10 |
0.692 |
|
| 2011 |
Makhlin I, Zhang J, Long CJ, Devarajan K, Zhou Y, Klein-Szanto AJ, Huang M, Chernoff J, Boorjian SA. The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. Bju International. 108: E84-90. PMID 21050361 DOI: 10.1111/J.1464-410X.2010.09844.X |
0.374 |
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| 2011 |
Stepanova D, Chernoff J. PAK1 (p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)) Atlas of Genetics and Cytogenetics in Oncology and Haematology. DOI: 10.4267/2042/38554 |
0.784 |
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| 2011 |
Chernoff J. STK4 (serine/threonine kinase 4) Atlas of Genetics and Cytogenetics in Oncology and Haematology. DOI: 10.4267/2042/38296 |
0.408 |
|
| 2011 |
Dorrance AM, Kosoff R, McGuinness M, Harris C, De Vita S, Mathieu R, Lane SW, Milsom MD, Chernoff J, Williams DA. Pak A Proteins Are Essential for Hematopoietic Stem/Progenitor Cell (HSC/P) Engraftment Through Regulation of Signaling Pathways Controlling HSC/P Proliferation, Survival, Migration, and the Actin Cytoskeleton Blood. 118: 917-917. DOI: 10.1182/Blood.V118.21.917.917 |
0.799 |
|
| 2011 |
Taglieri DM, Knezevic II, Chernoff J, Solaro RJ, Ke Y. Erk1-Mediated Development of Left Ventricular Cardiac Hypertrophy in a P21 Activated Kinase-1 (Pak1) Knockout Mouse Model Biophysical Journal. 100: 289a. DOI: 10.1016/J.Bpj.2010.12.1783 |
0.323 |
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| 2010 |
Arias-Romero LE, Chernoff J. p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? Small Gtpases. 1: 124-128. PMID 21686266 DOI: 10.4161/Sgtp.1.2.14109 |
0.523 |
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| 2010 |
Van den Broeke C, Radu M, Nauwynck HJ, Chernoff J, Favoreel HW. Role of group A p21-activated kinases in the anti-apoptotic activity of the pseudorabies virus US3 protein kinase. Virus Research. 155: 376-80. PMID 21093504 DOI: 10.1016/J.Virusres.2010.11.003 |
0.43 |
|
| 2010 |
Chow HY, Stepanova D, Koch J, Chernoff J. p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2. Plos One. 5: e13791. PMID 21072183 DOI: 10.1371/Journal.Pone.0013791 |
0.825 |
|
| 2010 |
Kosoff R, Chernoff J. LOV conquers (sm)All GTPases. F1000 Biology Reports. 2. PMID 20948805 DOI: 10.3410/B2-28 |
0.769 |
|
| 2010 |
Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene. 29: 5839-49. PMID 20711231 DOI: 10.1038/Onc.2010.318 |
0.822 |
|
| 2010 |
Menges CW, Chen Y, Mossman BT, Chernoff J, Yeung AT, Testa JR. A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. Genes & Cancer. 1: 493-505. PMID 20672017 DOI: 10.1177/1947601910375273 |
0.512 |
|
| 2010 |
Molli PR, Li DQ, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. The Journal of Cell Biology. 190: 101-14. PMID 20603326 DOI: 10.1083/Jcb.200908050 |
0.497 |
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| 2010 |
Yip SC, Saha S, Chernoff J. PTP1B: a double agent in metabolism and oncogenesis. Trends in Biochemical Sciences. 35: 442-9. PMID 20381358 DOI: 10.1016/J.Tibs.2010.03.004 |
0.336 |
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| 2010 |
Van den Broeke C, Radu M, Chernoff J, Favoreel HW. An emerging role for p21-activated kinases (Paks) in viral infections. Trends in Cell Biology. 20: 160-9. PMID 20071173 DOI: 10.1016/J.Tcb.2009.12.005 |
0.435 |
|
| 2010 |
Pacheco A, Chernoff J. Group I p21-activated kinases: Emerging roles in immune function and viral pathogenesis International Journal of Biochemistry and Cell Biology. 42: 13-16. PMID 19747561 DOI: 10.1016/J.Biocel.2009.09.006 |
0.433 |
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| 2010 |
Dorrance AM, Sanchez-Aguilera A, Vita SD, Milsom MD, Chernoff J, Williams DA. Group A Pak Proteins Are Essential for HSC/P Engraftment. Blood. 116: 2624-2624. DOI: 10.1182/Blood.V116.21.2624.2624 |
0.428 |
|
| 2010 |
Boorjian S, Zhang J, Makhlin I, Long C, Devarajan K, Zhou Y, Huang M, Chernoff J. 775 THE MTOR PATHWAY IMPACTS PROLIFERATION AND CHEMOSENSITIVITY OF UROTHELIAL CARCINOMA CELLS IN VITRO AND IS HIGHLY EXPRESSED IN A SUBSET OF HUMAN BLADDER CANCERS Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.1424 |
0.358 |
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| 2009 |
Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. Plos One. 4: e6025. PMID 19557173 DOI: 10.1371/Journal.Pone.0006025 |
0.438 |
|
| 2009 |
Radu M, Chernoff J. The DeMSTification of mammalian Ste20 kinases. Current Biology : Cb. 19: R421-5. PMID 19467213 DOI: 10.1016/J.Cub.2009.04.022 |
0.491 |
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| 2009 |
Arias-Romero LE, Saha S, Villamar-Cruz O, Yip SC, Ethier SP, Zhang ZY, Chernoff J. Activation of Src by protein tyrosine phosphatase 1B Is required for ErbB2 transformation of human breast epithelial cells. Cancer Research. 69: 4582-8. PMID 19435911 DOI: 10.1158/0008-5472.Can-08-4001 |
0.446 |
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| 2009 |
Van den Broeke C, Radu M, Deruelle M, Nauwynck H, Hofmann C, Jaffer ZM, Chernoff J, Favoreel HW. Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases. Proceedings of the National Academy of Sciences of the United States of America. 106: 8707-12. PMID 19435845 DOI: 10.1073/Pnas.0900436106 |
0.433 |
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| 2009 |
Flaiz C, Chernoff J, Ammoun S, Peterson JR, Hanemann CO. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Experimental Neurology. 218: 137-44. PMID 19409384 DOI: 10.1016/J.Expneurol.2009.04.019 |
0.494 |
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| 2009 |
Allen JD, Jaffer ZM, Park SJ, Burgin S, Hofmann C, Sells MA, Chen S, Derr-Yellin E, Michels EG, McDaniel A, Bessler WK, Ingram DA, Atkinson SJ, Travers JB, Chernoff J, et al. p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. Blood. 113: 2695-705. PMID 19124833 DOI: 10.1182/Blood-2008-06-160861 |
0.387 |
|
| 2008 |
Smith SD, Jaffer ZM, Chernoff J, Ridley AJ. PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. Journal of Cell Science. 121: 3729-36. PMID 18940914 DOI: 10.1242/Jcs.027680 |
0.437 |
|
| 2008 |
McDaniel AS, Allen JD, Park SJ, Jaffer ZM, Michels EG, Burgin SJ, Chen S, Bessler WK, Hofmann C, Ingram DA, Chernoff J, Clapp DW. Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells. Blood. 112: 4646-54. PMID 18768391 DOI: 10.1182/Blood-2008-04-155085 |
0.478 |
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| 2008 |
Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chemistry & Biology. 15: 322-31. PMID 18420139 DOI: 10.1016/J.Chembiol.2008.03.005 |
0.48 |
|
| 2008 |
Arias-Romero LE, Chernoff J. A tale of two Paks. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 100: 97-108. PMID 18199048 DOI: 10.1042/Bc20070109 |
0.489 |
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| 2008 |
Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, Liang Q. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. Journal of Molecular and Cellular Cardiology. 44: 429-34. PMID 18054038 DOI: 10.1016/J.Yjmcc.2007.10.016 |
0.498 |
|
| 2007 |
Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of Cell Science. 120: 3700-12. PMID 17911169 DOI: 10.1242/Jcs.03484 |
0.399 |
|
| 2007 |
Rennefahrt UE, Deacon SW, Parker SA, Devarajan K, Beeser A, Chernoff J, Knapp S, Turk BE, Peterson JR. Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. The Journal of Biological Chemistry. 282: 15667-78. PMID 17392278 DOI: 10.1074/Jbc.M700253200 |
0.436 |
|
| 2007 |
Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov A, Rauscher F, Shuai K, Ng T, Neel BG, Chernoff J. Regulation of protein tyrosine phosphatase 1B by sumoylation Nature Cell Biology. 9: 80-85. PMID 17159996 DOI: 10.1038/Ncb1522 |
0.435 |
|
| 2007 |
McDaniel A, Clapp DW, Chernoff J. Loss of Pak1 Corrects Multiple Gain of Function Phenotypes in Nf1+/− Mast Cells. Blood. 110: 236-236. DOI: 10.1182/blood.v110.11.236.236 |
0.42 |
|
| 2006 |
Thullberg M, Gad A, Beeser A, Chernoff J, Strömblad S. The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. Oncogene. 26: 1820-8. PMID 17001318 DOI: 10.1038/Sj.Onc.1209983 |
0.501 |
|
| 2006 |
Peterson JR, Chernoff J. Src transforms in a Cool way. Nature Cell Biology. 8: 905-7. PMID 16946737 DOI: 10.1038/Ncb0906-905 |
0.41 |
|
| 2006 |
Pirruccello M, Sondermann H, Pelton JG, Pellicena P, Hoelz A, Chernoff J, Wemmer DE, Kuriyan J. A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. Journal of Molecular Biology. 361: 312-26. PMID 16837009 DOI: 10.1016/J.Jmb.2006.06.017 |
0.437 |
|
| 2006 |
Cotteret S, Chernoff J. Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Molecular and Cellular Biology. 26: 3215-30. PMID 16581795 DOI: 10.1128/Mcb.26.8.3215-3230.2006 |
0.387 |
|
| 2006 |
ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL. Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. The Journal of Cell Biology. 172: 759-69. PMID 16492808 DOI: 10.1083/Jcb.200509096 |
0.367 |
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| 2005 |
Bartholomew PJ, Jones CW, Benware A, Chernoff J, LaFlamme SE. Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. Experimental Cell Research. 311: 294-306. PMID 16289152 DOI: 10.1016/J.Yexcr.2005.10.005 |
0.51 |
|
| 2005 |
Beeser A, Chernoff J. Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. Methods (San Diego, Calif.). 37: 203-7. PMID 16288885 DOI: 10.1016/J.Ymeth.2005.05.017 |
0.509 |
|
| 2005 |
Li S, Depetris RS, Barford D, Chernoff J, Hubbard SR. Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure (London, England : 1993). 13: 1643-51. PMID 16271887 DOI: 10.1016/J.Str.2005.07.019 |
0.36 |
|
| 2005 |
Cotteret S, Chernoff J. Pak GITs to Aurora-A. Developmental Cell. 9: 573-4. PMID 16256730 DOI: 10.1016/J.Devcel.2005.10.005 |
0.488 |
|
| 2005 |
Beeser A, Jaffer ZM, Hofmann C, Chernoff J. Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. The Journal of Biological Chemistry. 280: 36609-15. PMID 16129686 DOI: 10.1074/Jbc.M502306200 |
0.488 |
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| 2005 |
Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV. Essential role of CIB1 in regulating PAK1 activation and cell migration. The Journal of Cell Biology. 170: 465-76. PMID 16061695 DOI: 10.1083/Jcb.200502090 |
0.505 |
|
| 2005 |
Gonzalez Guerrico AM, Jaffer ZM, Page RE, Braunewell KH, Chernoff J, Klein-Szanto AJ. Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene. 24: 2307-16. PMID 15735716 DOI: 10.1038/Sj.Onc.1208476 |
0.395 |
|
| 2005 |
Parsons M, Monypenny J, Ameer-Beg SM, Millard TH, Machesky LM, Peter M, Keppler MD, Schiavo G, Watson R, Chernoff J, Zicha D, Vojnovic B, Ng T. Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Molecular and Cellular Biology. 25: 1680-95. PMID 15713627 DOI: 10.1128/Mcb.25.5.1680-1695.2005 |
0.416 |
|
| 2005 |
Sorokina EM, Chernoff J. Rho-GTPases: new members, new pathways. Journal of Cellular Biochemistry. 94: 225-31. PMID 15543593 DOI: 10.1002/Jcb.20327 |
0.373 |
|
| 2004 |
Hofmann C, Shepelev M, Chernoff J. The genetics of Pak. Journal of Cell Science. 117: 4343-54. PMID 15331659 DOI: 10.1242/Jcs.01392 |
0.418 |
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| 2004 |
Jaffer ZM, Chernoff J. The cross-Rho'ds of cell-cell adhesion. The Journal of Biological Chemistry. 279: 35123-6. PMID 15133033 DOI: 10.1074/Jbc.R400010200 |
0.323 |
|
| 2004 |
Golemis EA, Chernoff J. Analysis and manipulation of intracellular signaling cascades. Methods (San Diego, Calif.). 32: 347-8. PMID 15003596 DOI: 10.1016/J.Ymeth.2003.10.009 |
0.313 |
|
| 2004 |
Reynolds LF, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz VL. Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. The Journal of Biological Chemistry. 279: 18239-46. PMID 14764585 DOI: 10.1074/Jbc.M400257200 |
0.451 |
|
| 2003 |
Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A. AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Research. 63: 6802-8. PMID 14583477 |
0.337 |
|
| 2003 |
Xiao GH, Chernoff J, Testa JR. NF2: the wizardry of merlin. Genes, Chromosomes & Cancer. 38: 389-99. PMID 14566860 DOI: 10.1002/Gcc.10282 |
0.376 |
|
| 2003 |
Zegers MM, Forget MA, Chernoff J, Mostov KE, ter Beest MB, Hansen SH. Pak1 and PIX regulate contact inhibition during epithelial wound healing. The Embo Journal. 22: 4155-65. PMID 12912914 DOI: 10.1093/Emboj/Cdg398 |
0.456 |
|
| 2003 |
Dadke S, Chernoff J. Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. The Journal of Biological Chemistry. 278: 40607-11. PMID 12902327 DOI: 10.1074/Jbc.M306772200 |
0.384 |
|
| 2003 |
Cotteret S, Jaffer ZM, Beeser A, Chernoff J. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Molecular and Cellular Biology. 23: 5526-39. PMID 12897128 DOI: 10.1128/Mcb.23.16.5526-5539.2003 |
0.474 |
|
| 2003 |
Deacon K, Mistry P, Chernoff J, Blank JL, Patel R. p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Molecular Biology of the Cell. 14: 2071-87. PMID 12802076 DOI: 10.1091/Mbc.E02-10-0653 |
0.454 |
|
| 2003 |
Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, Allis CD. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 113: 507-17. PMID 12757711 DOI: 10.1016/S0092-8674(03)00355-6 |
0.377 |
|
| 2003 |
Penzes P, Beeser A, Chernoff J, Schiller MR, Eipper BA, Mains RE, Huganir RL. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron. 37: 263-74. PMID 12546821 DOI: 10.1016/S0896-6273(02)01168-6 |
0.304 |
|
| 2002 |
Astrinidis A, Cash TP, Hunter DS, Walker CL, Chernoff J, Henske EP. Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration. Oncogene. 21: 8470-6. PMID 12466966 DOI: 10.1038/Sj.Onc.1205962 |
0.47 |
|
| 2002 |
Nikolic M, Chernoff J. High midsummer for small GTPases. Trends in Cell Biology. 12: 495-7. PMID 12446103 DOI: 10.1016/S0962-8924(02)02365-6 |
0.354 |
|
| 2002 |
Serebriiskii IG, Mitina O, Pugacheva EN, Benevolenskaya E, Kotova E, Toby GG, Khazak V, Kaelin WG, Chernoff J, Golemis EA. Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Research. 12: 1785-91. PMID 12421766 DOI: 10.1101/Gr.450702 |
0.315 |
|
| 2002 |
Thiel DA, Reeder MK, Pfaff A, Coleman TR, Sells MA, Chernoff J. Cell cycle-regulated phosphorylation of p21-activated kinase 1. Current Biology : Cb. 12: 1227-32. PMID 12176333 DOI: 10.1016/S0960-9822(02)00931-4 |
0.482 |
|
| 2002 |
Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, Mandal M, Kumar R. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. Embo Reports. 3: 767-73. PMID 12151336 DOI: 10.1093/Embo-Reports/Kvf157 |
0.439 |
|
| 2002 |
Dadke S, Chernoff J. Interaction of protein tyrosine phosphatase (PTP) 1B with its substrates is influenced by two distinct binding domains. The Biochemical Journal. 364: 377-83. PMID 12023880 DOI: 10.1042/Bj20011372 |
0.377 |
|
| 2002 |
Jaffer ZM, Chernoff J. p21-activated kinases: three more join the Pak. The International Journal of Biochemistry & Cell Biology. 34: 713-7. PMID 11950587 DOI: 10.1016/S1357-2725(01)00158-3 |
0.494 |
|
| 2002 |
Cotteret S, Chernoff J. The evolutionary history of effectors downstream of Cdc42 and Rac. Genome Biology. 3: REVIEWS0002. PMID 11864373 DOI: 10.1186/Gb-2002-3-2-Reviews0002 |
0.402 |
|
| 2002 |
Xiao GH, Beeser A, Chernoff J, Testa JR. p21-activated kinase links Rac/Cdc42 signaling to merlin. The Journal of Biological Chemistry. 277: 883-6. PMID 11719502 DOI: 10.1074/Jbc.C100553200 |
0.519 |
|
| 2001 |
Reeder MK, Serebriiskii IG, Golemis EA, Chernoff J. Analysis of small GTPase signaling pathways using p21-activated kinase mutants that selectively couple to Cdc42. The Journal of Biological Chemistry. 276: 40606-13. PMID 11514549 DOI: 10.1074/Jbc.M103925200 |
0.447 |
|
| 2001 |
Serebriiskii IG, Mitina OV, Chernoff J, Golemis EA. Two-hybrid dual bait system to discriminate specificity of protein interactions in small GTPases. Methods in Enzymology. 332: 277-300. PMID 11305104 DOI: 10.1016/S0076-6879(01)32210-3 |
0.312 |
|
| 2001 |
Sells MA, Pfaff A, Chernoff J. Temporal and spatial distribution of activated Pak1 in fibroblasts. The Journal of Cell Biology. 151: 1449-58. PMID 11134074 DOI: 10.1083/Jcb.151.7.1449 |
0.449 |
|
| 2001 |
Mota M, Reeder M, Chernoff J, Bazenet CE. Evidence for a Role of Mixed Lineage Kinases in Neuronal Apoptosis The Journal of Neuroscience. 21: 4949-4957. DOI: 10.1523/Jneurosci.21-14-04949.2001 |
0.408 |
|
| 2000 |
Arora VK, Molina RP, Foster JL, Blakemore JL, Chernoff J, Fredericksen BL, Garcia JV. Lentivirus Nef specifically activates Pak2. Journal of Virology. 74: 11081-7. PMID 11070003 DOI: 10.1128/Jvi.74.23.11081-11087.2000 |
0.418 |
|
| 2000 |
Dharmawardhane S, Schürmann A, Sells MA, Chernoff J, Schmid SL, Bokoch GM. Regulation of macropinocytosis by p21-activated kinase-1. Molecular Biology of the Cell. 11: 3341-52. PMID 11029040 DOI: 10.1091/Mbc.11.10.3341 |
0.458 |
|
| 2000 |
Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A, Chernoff J, Hung MC, Kumar R. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. The Journal of Biological Chemistry. 275: 36238-44. PMID 10945974 DOI: 10.1074/Jbc.M002138200 |
0.477 |
|
| 2000 |
Dadke S, Kusari J, Chernoff J. Down-regulation of insulin signaling by protein-tyrosine phosphatase 1B is mediated by an N-terminal binding region. The Journal of Biological Chemistry. 275: 23642-7. PMID 10807907 DOI: 10.1074/Jbc.M001063200 |
0.358 |
|
| 2000 |
Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R. Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. The Journal of Biological Chemistry. 275: 12041-50. PMID 10766836 DOI: 10.1074/Jbc.275.16.12041 |
0.452 |
|
| 2000 |
Valster AH, Hepler PK, Chernoff J. Plant GTPases: the Rhos in bloom. Trends in Cell Biology. 10: 141-6. PMID 10740268 DOI: 10.1016/S0962-8924(00)01728-1 |
0.339 |
|
| 1999 |
Chernoff J. Close encounters of the LIM-kinase. Nature Cell Biology. 1: E115-7. PMID 10559948 DOI: 10.1038/12942 |
0.346 |
|
| 1999 |
Chernoff J. Protein tyrosine phosphatases as negative regulators of mitogenic signaling. Journal of Cellular Physiology. 180: 173-81. PMID 10395287 DOI: 10.1002/(Sici)1097-4652(199908)180:2<173::Aid-Jcp5>3.0.Co;2-Y |
0.509 |
|
| 1999 |
Sells MA, Boyd JT, Chernoff J. p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts. The Journal of Cell Biology. 145: 837-49. PMID 10330410 DOI: 10.1083/Jcb.145.4.837 |
0.467 |
|
| 1998 |
Bubeck Wardenburg J, Pappu R, Bu JY, Mayer B, Chernoff J, Straus D, Chan AC. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity. 9: 607-16. PMID 9846482 DOI: 10.1016/S1074-7613(00)80658-5 |
0.463 |
|
| 1998 |
Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. The Journal of Biological Chemistry. 273: 28238-46. PMID 9774445 DOI: 10.1074/Jbc.273.43.28238 |
0.497 |
|
| 1998 |
Sells MA, Barratt JT, Caviston J, Ottilie S, Leberer E, Chernoff J. Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast. The Journal of Biological Chemistry. 273: 18490-8. PMID 9660818 DOI: 10.1074/Jbc.273.29.18490 |
0.742 |
|
| 1998 |
Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. The Embo Journal. 17: 2224-34. PMID 9545236 DOI: 10.1093/Emboj/17.8.2224 |
0.413 |
|
| 1998 |
Zhang B, Chernoff J, Zheng Y. Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. The Journal of Biological Chemistry. 273: 8776-82. PMID 9535855 DOI: 10.1074/Jbc.273.15.8776 |
0.387 |
|
| 1998 |
Liu F, Sells MA, Chernoff J. Protein tyrosine phosphatase 1B negatively regulates integrin signaling. Current Biology : Cb. 8: 173-6. PMID 9443918 DOI: 10.1016/S0960-9822(98)70066-1 |
0.557 |
|
| 1998 |
Liu F, Sells MA, Chernoff J. Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand. Molecular and Cellular Biology. 18: 250-9. PMID 9418872 DOI: 10.1128/Mcb.18.1.250 |
0.484 |
|
| 1997 |
Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells Current Biology. 7: 202-210. PMID 9395435 DOI: 10.1016/S0960-9822(97)70091-5 |
0.468 |
|
| 1997 |
Liu F, Chernoff J. Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor. The Biochemical Journal. 139-45. PMID 9355745 DOI: 10.1042/Bj3270139 |
0.456 |
|
| 1997 |
Tang Y, Chen Z, Ambrose D, Liu J, Gibbs JB, Chernoff J, Field J. Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Molecular and Cellular Biology. 17: 4454-64. PMID 9234703 DOI: 10.1128/Mcb.17.8.4454 |
0.367 |
|
| 1997 |
Bandyopadhyay D, Kusari A, Kenner KA, Liu F, Chernoff J, Gustafson TA, Kusari J. Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. The Journal of Biological Chemistry. 272: 1639-45. PMID 8999839 DOI: 10.1074/Jbc.272.3.1639 |
0.371 |
|
| 1997 |
Liu F, Hill DE, Chernoff J. Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas). The Journal of Biological Chemistry. 271: 31290-5. PMID 8940134 DOI: 10.1074/Jbc.271.49.31290 |
0.411 |
|
| 1996 |
Galisteo ML, Chernoff J, Su YC, Skolnik EY, Schlessinger J. The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. The Journal of Biological Chemistry. 271: 20997-1000. PMID 8798379 DOI: 10.1074/Jbc.271.35.20997 |
0.452 |
|
| 1996 |
Creasy CL, Ambrose DM, Chernoff J. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain Journal of Biological Chemistry. 271: 21049-21053. PMID 8702870 DOI: 10.1074/Jbc.271.35.21049 |
0.435 |
|
| 1996 |
Creasy CL, Chernoff J. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene. 167: 303-6. PMID 8566796 DOI: 10.1016/0378-1119(95)00653-2 |
0.417 |
|
| 1996 |
Bagrodia S, Taylor SJ, Creasy CL, Chernoff J, Cerione RA. Identification of a mouse p21cdc42/Racactivated kinase. Journal of Biological Chemistry. 271: 1250.1-1250. DOI: 10.1074/Jbc.271.2.1250 |
0.417 |
|
| 1995 |
Creasy CL, Chernoff J. Cloning and characterization of a human protein kinase with homology to Ste20. The Journal of Biological Chemistry. 270: 21695-700. PMID 7665586 DOI: 10.1074/Jbc.270.37.21695 |
0.508 |
|
| 1995 |
Knaus UG, Morris S, Dong HJ, Chernoff J, Bokoch GM. Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science (New York, N.Y.). 269: 221-3. PMID 7618083 DOI: 10.1126/Science.7618083 |
0.422 |
|
| 1995 |
Vambutas V, Kaplan DR, Sells MA, Chernoff J. Nerve growth factor stimulates tyrosine phosphorylation and activation of Src homology-containing protein-tyrosine phosphatase 1 in PC12 cells Journal of Biological Chemistry. 270: 25629-25633. PMID 7592737 DOI: 10.1074/Jbc.270.43.25629 |
0.393 |
|
| 1995 |
Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ, Bokoch GM. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. The Journal of Biological Chemistry. 270: 23934-6. PMID 7592586 DOI: 10.1074/Jbc.270.41.23934 |
0.465 |
|
| 1995 |
Bagrodia S, Taylor SJ, Creasy CL, Chernoff J, Cerione RA. Identification of a mouse p21Cdc42/Rac activated kinase Journal of Biological Chemistry. 270: 22731-22737. PMID 7559398 DOI: 10.1074/Jbc.270.39.22731 |
0.439 |
|
| 1995 |
Ottilie S, Miller PJ, Johnson DI, Creasy CL, Sells MA, Bagrodia S, Forsburg SL, Chernoff J. Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating. The Embo Journal. 14: 5908-5919. DOI: 10.1002/J.1460-2075.1995.Tb00278.X |
0.743 |
|
| 1994 |
Patriotis C, Makris A, Chernoff J, Tsichlis PN. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase Proceedings of the National Academy of Sciences of the United States of America. 91: 9755-9759. PMID 7937886 DOI: 10.1073/Pnas.91.21.9755 |
0.472 |
|
| 1992 |
Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. The fission yeast genes pyp1+ and pyp2+ encode protein tyrosine phosphatases that negatively regulate mitosis. Molecular and Cellular Biology. 12: 5571-80. PMID 1448087 DOI: 10.1128/Mcb.12.12.5571 |
0.77 |
|
| 1991 |
Ottilie S, Chernoff J, Hannig G, Hoffman CS, Erikson RL. A fission-yeast gene encoding a protein with features of protein-tyrosine-phosphatases. Proceedings of the National Academy of Sciences of the United States of America. 88: 3455-9. PMID 1849659 DOI: 10.1073/Pnas.88.8.3455 |
0.734 |
|
| 1990 |
Chernoff J, Schievella AR, Jost CA, Erikson RL, Neel BG. Cloning of a cDNA for a major human protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 87: 2735-9. PMID 2157211 DOI: 10.1073/Pnas.87.7.2735 |
0.533 |
|
| 1985 |
Chernoff J, Li HC. A major phosphotyrosyl-protein phosphatase from bovine heart is associated with a low-molecular-weight acid phosphatase Archives of Biochemistry and Biophysics. 240: 135-145. PMID 2990341 DOI: 10.1016/0003-9861(85)90016-5 |
0.313 |
|
| 1984 |
Chernoff J, Sells MA, Li HC. Characterization of phosphotyrosyl-protein phosphatase activity associated with calcineurin. Biochemical and Biophysical Research Communications. 121: 141-8. PMID 6329193 DOI: 10.1016/0006-291X(84)90698-3 |
0.367 |
|
| 1983 |
Chernoff J, Li HC. Multiple forms of phosphotyrosyl- and phosphoseryl-protein phosphatase from cardiac muscle: Partial purification and characterization of an EDTA-stimulated phosphotyrosyl-protein phosphatase Archives of Biochemistry and Biophysics. 226: 517-530. PMID 6314904 DOI: 10.1016/0003-9861(83)90321-1 |
0.358 |
|
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