H. Lee Sweeney - Publications

Affiliations: 
1984 Physiology and Biophysics Harvard Medical School, Boston, MA, United States 

114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Canon L, Kikuti C, Planelles-Herrero VJ, Lin T, Mayeux F, Sirkia H, Lee YI, Heidsieck L, Velikovsky L, David A, Liu X, Moussaoui D, Forest E, Höök P, Petersen KJ, ... ... Sweeney HL, et al. How myosin VI traps its off-state, is activated and dimerizes. Nature Communications. 14: 6732. PMID 37872146 DOI: 10.1038/s41467-023-42376-2  0.606
2023 Bodine SC, Sinha I, Sweeney HL. Mechanisms of Skeletal Muscle Atrophy and Molecular Circuitry of Stem Cell Fate in Skeletal Muscle Regeneration and Aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 78: 14-18. PMID 37325966 DOI: 10.1093/gerona/glad023  0.313
2023 Russell AJ, DuVall M, Barthel B, Qian Y, Peter AK, Newell-Stamper BL, Hunt K, Lehman SJ, Madden MR, Schlachter ST, Robertson BD, Van Deusen A, Rodriguez HM, Vera CD, Su Y, ... ... Sweeney HL, et al. Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy. The Journal of Clinical Investigation. PMID 36995778 DOI: 10.1172/JCI153837  0.649
2021 Pospich S, Sweeney HL, Houdusse A, Raunser S. High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism. Elife. 10. PMID 34812732 DOI: 10.7554/eLife.73724  0.625
2021 Hammers DW, Hart CC, Matheny MK, Heimsath EG, Lee YI, Hammer JA, Cheney RE, Sweeney HL. Filopodia powered by class X myosin promote fusion of mammalian myoblasts. Elife. 10. PMID 34519272 DOI: 10.7554/eLife.72419  0.355
2020 Hammers DW, Hart CC, Matheny MK, Wright LA, Armellini M, Barton ER, Sweeney HL. The D2.mdx mouse as a preclinical model of the skeletal muscle pathology associated with Duchenne muscular dystrophy. Scientific Reports. 10: 14070. PMID 32826942 DOI: 10.1038/S41598-020-70987-Y  0.613
2020 Sweeney HL, Houdusse A, Robert-Paganin J. Myosin Structures. Advances in Experimental Medicine and Biology. 1239: 7-19. PMID 32451853 DOI: 10.1007/978-3-030-38062-5_2  0.639
2019 Hammers DW, Hart CC, Patsalos A, Matheny MK, Wright LA, Nagy L, Sweeney HL. Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle. Jci Insight. PMID 31830002 DOI: 10.1172/Jci.Insight.133276  0.31
2019 Robert-Paganin J, Pylypenko O, Kikuti C, Sweeney HL, Houdusse A. Force Generation by Myosin Motors: A Structural Perspective. Chemical Reviews. PMID 31689091 DOI: 10.1021/Acs.Chemrev.9B00264  0.604
2019 Barton ER, Pham J, Brisson BK, Park S, Smith LR, Liu M, Tian Z, Hammers DW, Vassilakos G, Sweeney HL. Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. Muscle & Nerve. PMID 31323135 DOI: 10.1002/Mus.26641  0.601
2019 Yang Y, Vassilakos G, Hammers DW, Yang Z, Barton ER, Sweeney HL. Smooth muscle atrophy and colon pathology in SMN deficient mice. American Journal of Translational Research. 11: 1789-1799. PMID 30972202  0.606
2018 Blanc F, Isabet T, Benisty H, Sweeney HL, Cecchini M, Houdusse A. An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics. Proceedings of the National Academy of Sciences of the United States of America. PMID 29844196 DOI: 10.1073/Pnas.1711512115  0.589
2018 Sweeney HL, Hammers DW. Muscle Contraction. Cold Spring Harbor Perspectives in Biology. 10. PMID 29419405 DOI: 10.1101/cshperspect.a023200  0.35
2017 Hammers DW, Merscham-Banda M, Hsiao JY, Engst S, Hartman JJ, Sweeney HL. Supraphysiological levels of GDF11 induce striated muscle atrophy. Embo Molecular Medicine. PMID 28270449 DOI: 10.15252/emmm.201607231  0.308
2016 Liu M, Hammers DW, Barton ER, Sweeney HL. Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy. Plos One. 11: e0166803. PMID 27870893 DOI: 10.1371/Journal.Pone.0166803  0.641
2016 Houdusse A, Sweeney HL. How Myosin Generates Force on Actin Filaments. Trends in Biochemical Sciences. PMID 27717739 DOI: 10.1016/J.Tibs.2016.09.006  0.607
2016 Ropars V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar CV, ... Sweeney HL, et al. The myosin X motor is optimized for movement on actin bundles. Nature Communications. 7: 12456. PMID 27580874 DOI: 10.1038/Ncomms12456  0.614
2016 Capote J, Kramerova I, Martinez L, Vetrone S, Barton ER, Sweeney HL, Miceli MC, Spencer MJ. Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. The Journal of Cell Biology. 213: 275-88. PMID 27091452 DOI: 10.1083/Jcb.201510086  0.63
2016 Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse AM, Schröder RR. Force-producing ADP state of myosin bound to actin. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976594 DOI: 10.1073/Pnas.1516598113  0.618
2016 Abrams J, Einhorn Z, Seiler C, Zong AB, Sweeney HL, Pack M. Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility, and vascular function in zebrafish. Disease Models & Mechanisms. PMID 26893369 DOI: 10.1242/dmm.023309  0.307
2016 Schroeder RR, Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse A. The Force Producing ADP State of Myosin Bound to Actin Biophysical Journal. 110: 13a. DOI: 10.1016/j.bpj.2015.11.129  0.584
2015 Smith LR, Hammers DW, Sweeney HL, Barton ER. Increased collagen cross-linking is a signature of dystrophin-deficient muscle. Muscle & Nerve. PMID 26616495 DOI: 10.1002/Mus.24998  0.602
2015 Llinas P, Isabet T, Song L, Ropars V, Zong B, Benisty H, Sirigu S, Morris C, Kikuti C, Safer D, Sweeney HL, Houdusse A. How actin initiates the motor activity of Myosin. Developmental Cell. 33: 401-12. PMID 25936506 DOI: 10.1016/J.Bpj.2014.11.160  0.641
2015 Pylypenko O, Song L, Shima A, Yang Z, Houdusse AM, Sweeney HL. Myosin VI deafness mutation prevents the initiation of processive runs on actin. Proceedings of the National Academy of Sciences of the United States of America. 112: E1201-9. PMID 25751888 DOI: 10.1073/Pnas.1420989112  0.613
2014 Mukherjea M, Ali MY, Kikuti C, Safer D, Yang Z, Sirkia H, Ropars V, Houdusse A, Warshaw DM, Sweeney HL. Myosin VI must dimerize and deploy its unusual lever arm in order to perform its cellular roles. Cell Reports. 8: 1522-32. PMID 25159143 DOI: 10.1016/J.Celrep.2014.07.041  0.619
2014 Tsai MH, Chang AN, Huang J, He W, Sweeney HL, Zhu M, Kamm KE, Stull JT. Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle. The Journal of Physiology. 592: 3031-51. PMID 24835173 DOI: 10.1113/Jphysiol.2014.273011  0.311
2014 Forbes SC, Bish LT, Ye F, Spinazzola J, Baligand C, Plant D, Vandenborne K, Barton ER, Sweeney HL, Walter GA. Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus. Gene Therapy. 21: 387-92. PMID 24572791 DOI: 10.1038/Gt.2014.9  0.571
2013 Selsby JT, Acosta P, Sleeper MM, Barton ER, Sweeney HL. Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse. Journal of Applied Physiology (Bethesda, Md. : 1985). 115: 660-6. PMID 23823150 DOI: 10.1152/Japplphysiol.00252.2013  0.61
2013 Ye F, Mathur S, Liu M, Borst SE, Walter GA, Sweeney HL, Vandenborne K. Overexpression of insulin-like growth factor-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse. Experimental Physiology. 98: 1038-52. PMID 23291913 DOI: 10.1113/Expphysiol.2012.070722  0.311
2013 Ali MY, Previs SB, Trybus KM, Sweeney HL, Warshaw DM. Myosin VI has a one track mind versus myosin Va when moving on actin bundles or at an intersection. Traffic (Copenhagen, Denmark). 14: 70-81. PMID 23046080 DOI: 10.1111/tra.12017  0.309
2012 Ménétrey J, Isabet T, Ropars V, Mukherjea M, Pylypenko O, Liu X, Perez J, Vachette P, Sweeney HL, Houdusse AM. Processive steps in the reverse direction require uncoupling of the lead head lever arm of myosin VI. Molecular Cell. 48: 75-86. PMID 22940248 DOI: 10.1016/J.Molcel.2012.07.034  0.63
2012 Selsby JT, Morine KJ, Pendrak K, Barton ER, Sweeney HL. Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse. Plos One. 7: e30063. PMID 22253880 DOI: 10.1371/Journal.Pone.0030063  0.611
2012 Llinas P, Pylypenko O, Isabet T, Mukherjea M, Sweeney HL, Houdusse AM. How myosin motors power cellular functions: an exciting journey from structure to function: based on a lecture delivered at the 34th FEBS Congress in Prague, Czech Republic, July 2009. The Febs Journal. 279: 551-62. PMID 22171985 DOI: 10.1111/J.1742-4658.2011.08449.X  0.626
2012 Qaisar R, Renaud G, Morine K, Barton ER, Sweeney HL, Larsson L. Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level? Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1077-85. PMID 22125316 DOI: 10.1096/Fj.11-192195  0.659
2011 Bish LT, Yarchoan M, Sleeper MM, Gazzara JA, Morine KJ, Acosta P, Barton ER, Sweeney HL. Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice. Plos One. 6: e20856. PMID 21731628 DOI: 10.1371/Journal.Pone.0020856  0.62
2011 Pylypenko O, Song L, Squires G, Liu X, Zong AB, Houdusse A, Sweeney HL. Role of insert-1 of myosin VI in modulating nucleotide affinity. The Journal of Biological Chemistry. 286: 11716-23. PMID 21278381 DOI: 10.1074/Jbc.M110.200626  0.584
2011 Shima A, Pham J, Blanco E, Barton ER, Sweeney HL, Matsuda R. IGF-I and vitamin C promote myogenic differentiation of mouse and human skeletal muscle cells at low temperatures. Experimental Cell Research. 317: 356-66. PMID 21070767 DOI: 10.1016/J.Yexcr.2010.11.001  0.58
2011 Sen S, Tewari M, Zajac A, Barton E, Sweeney HL, Discher DE. Upregulation of paxillin and focal adhesion signaling follows Dystroglycan Complex deletions and promotes a hypertensive state of differentiation. European Journal of Cell Biology. 90: 249-60. PMID 20663583 DOI: 10.1016/J.Ejcb.2010.06.005  0.598
2010 Selsby J, Pendrak K, Zadel M, Tian Z, Pham J, Carver T, Acosta P, Barton E, Sweeney HL. Leupeptin-based inhibitors do not improve the mdx phenotype. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 299: R1192-201. PMID 20844259 DOI: 10.1152/Ajpregu.00586.2009  0.616
2010 Stevens-Lapsley JE, Ye F, Liu M, Borst SE, Conover C, Yarasheski KE, Walter GA, Sweeney HL, Vandenborne K. Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization. American Journal of Physiology. Endocrinology and Metabolism. 299: E730-40. PMID 20739512 DOI: 10.1152/Ajpendo.00230.2010  0.332
2010 Morine KJ, Bish LT, Selsby JT, Gazzara JA, Pendrak K, Sleeper MM, Barton ER, Lee SJ, Sweeney HL. Activin IIB receptor blockade attenuates dystrophic pathology in a mouse model of Duchenne muscular dystrophy. Muscle & Nerve. 42: 722-30. PMID 20730876 DOI: 10.1002/Mus.21743  0.606
2010 Wang B, Yang Z, Brisson BK, Feng H, Zhang Z, Welch EM, Peltz SW, Barton ER, Brown RH, Sweeney HL. Membrane blebbing as an assessment of functional rescue of dysferlin-deficient human myotubes via nonsense suppression. Journal of Applied Physiology (Bethesda, Md. : 1985). 109: 901-5. PMID 20558759 DOI: 10.1152/Japplphysiol.01366.2009  0.585
2010 Barton ER, Wang BJ, Brisson BK, Sweeney HL. Diaphragm displays early and progressive functional deficits in dysferlin-deficient mice. Muscle & Nerve. 42: 22-9. PMID 20544921 DOI: 10.1002/Mus.21645  0.643
2010 Morine KJ, Sleeper MM, Barton ER, Sweeney HL. Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage. Human Gene Therapy. 21: 1735-9. PMID 20540606 DOI: 10.1089/Hum.2010.077  0.61
2010 Sweeney HL, Houdusse A. Myosin VI Rewrites the Rules for Myosin Motors Cell. 141: 573-582. PMID 20478251 DOI: 10.1016/J.Cell.2010.04.028  0.635
2010 Sweeney HL, Houdusse A. Structural and functional insights into the myosin motor mechanism Annual Review of Biophysics. 39: 539-557. PMID 20192767 DOI: 10.1146/Annurev.Biophys.050708.133751  0.663
2010 Morine KJ, Bish LT, Pendrak K, Sleeper MM, Barton ER, Sweeney HL. Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice. Plos One. 5: e9176. PMID 20161803 DOI: 10.1371/Journal.Pone.0009176  0.578
2010 Shima A, Barton E, Sweeney H, Matsuda R. P3.20 Mouse and human skeletal muscle cells differentiate in a temperature-dependent manner Neuromuscular Disorders. 20: 647. DOI: 10.1016/J.Nmd.2010.07.162  0.596
2010 Kim H, Hsin J, Liu Y, Mukherjea M, Safer D, Houdusse A, Sweeney HL, Schulten K, Selvin PR. Single-Molecule and Molecular Dynamics Study of the Dimerization of Myosin VI Medial Tail Domain Biophysical Journal. 98: 724a. DOI: 10.1016/J.Bpj.2009.12.3969  0.574
2010 Mukherjea M, Llinas P, Safer D, Houdusse A, Sweeney HL. Dimerization is Essential for the Large Step Size of Myosin VI Biophysical Journal. 98: 724a. DOI: 10.1016/J.Bpj.2009.12.3967  0.638
2010 Liu Y, Hsin J, Kim H, Houdusse A, Sweeney HL, Selvin PR, Schulten K. Steered Molecular Dynamics Simulation of Unfolding of Myosin VI Proximal Tail Domain Biophysical Journal. 98: 724a. DOI: 10.1016/J.Bpj.2009.12.3966  0.588
2009 Mukherjea M, Llinas P, Kim H, Travaglia M, Safer D, Ménétrey J, Franzini-Armstrong C, Selvin PR, Houdusse A, Sweeney HL. Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach. Molecular Cell. 35: 305-15. PMID 19664948 DOI: 10.1016/J.Molcel.2009.07.010  0.636
2009 Qaiasr R, Morine K, Barton E, Sweeney H, Larsson L. EM.P.1.07 Effects of muscle hypertrophy on individual myonuclear domain sizes in single muscle fibers from myostatin deficient or IGF-1 over-expressing mice Neuromuscular Disorders. 19: 551. DOI: 10.1016/J.Nmd.2009.06.028  0.631
2009 Mukherjea M, Safer D, Ménétrey J, Llinas P, Houdusse A, Sweeney HL. Myosin VI Dimerizes And Walks Processively Along Actin Biophysical Journal. 96: 142a. DOI: 10.1016/J.Bpj.2008.12.3884  0.632
2009 Phichith D, Travaglia M, Yang Z, Zong AB, Safer D, Franzini-Armstrong C, Sweeney HL. Cargo-mediated dimerization of Myosin VI Biophysical Journal. 96: 141a. DOI: 10.1016/J.Bpj.2008.12.3877  0.35
2008 Millay DP, Sargent MA, Osinska H, Baines CP, Barton ER, Vuagniaux G, Sweeney HL, Robbins J, Molkentin JD. Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nature Medicine. 14: 442-7. PMID 18345011 DOI: 10.1038/Nm1736  0.6
2008 Ménétrey J, Llinas P, Cicolari J, Squires G, Liu X, Li A, Sweeney HL, Houdusse A. The post-rigor structure of myosin VI and implications for the recovery stroke. The Embo Journal. 27: 244-52. PMID 18046460 DOI: 10.1038/Sj.Emboj.7601937  0.627
2008 Houdusse A, Llinas P, Menetrey J, Cicolari J, Sweeney H. Structural description of the ATPase cycle of a myosin that moves backward Acta Crystallographica Section a Foundations of Crystallography. 64: C78-C79. DOI: 10.1107/S0108767308097481  0.565
2007 Ménétrey J, Llinas P, Mukherjea M, Sweeney HL, Houdusse A. The structural basis for the large powerstroke of myosin VI. Cell. 131: 300-8. PMID 17956731 DOI: 10.1016/J.Cell.2007.08.027  0.632
2007 Sweeney HL, Park H, Zong AB, Yang Z, Selvin PR, Rosenfeld SS. How myosin VI coordinates its heads during processive movement. The Embo Journal. 26: 2682-92. PMID 17510632 DOI: 10.1038/Sj.Emboj.7601720  0.319
2007 Welch EM, Barton ER, Zhuo J, Tomizawa Y, Friesen WJ, Trifillis P, Paushkin S, Patel M, Trotta CR, Hwang S, Wilde RG, Karp G, Takasugi J, Chen G, Jones S, ... ... Sweeney HL, et al. PTC124 targets genetic disorders caused by nonsense mutations. Nature. 447: 87-91. PMID 17450125 DOI: 10.1038/Nature05756  0.578
2007 Parsons SA, Millay DP, Sargent MA, Naya FJ, McNally EM, Sweeney HL, Molkentin JD. Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. The Journal of Biological Chemistry. 282: 10068-78. PMID 17289669 DOI: 10.1074/Jbc.M609368200  0.339
2007 Park H, Li A, Chen LQ, Houdusse A, Selvin PR, Sweeney HL. The unique insert at the end of the myosin VI motor is the sole determinant of directionality. Proceedings of the National Academy of Sciences of the United States of America. 104: 778-83. PMID 17213313 DOI: 10.1073/Pnas.0610066104  0.619
2007 Sweeney HL, Houdusse A. What can myosin VI do in cells? Current Opinion in Cell Biology. 19: 57-66. PMID 17175153 DOI: 10.1016/J.Ceb.2006.12.005  0.622
2005 Chevreux G, Potier N, Van Dorsselaer A, Bahloul A, Houdusse A, Wells A, Sweeney HL. Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site. Journal of the American Society For Mass Spectrometry. 16: 1367-76. PMID 15979337 DOI: 10.1016/J.Jasms.2005.03.023  0.581
2005 Morris CA, Morris LD, Kennedy AR, Sweeney HL. Attenuation of skeletal muscle atrophy via protease inhibition. Journal of Applied Physiology (Bethesda, Md. : 1985). 99: 1719-27. PMID 15976355 DOI: 10.1152/japplphysiol.01419.2004  0.314
2005 Ménétrey J, Bahloul A, Wells AL, Yengo CM, Morris CA, Sweeney HL, Houdusse A. The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature. 435: 779-85. PMID 15944696 DOI: 10.1038/Nature03592  0.638
2005 Rosenfeld SS, Houdusse A, Sweeney HL. Magnesium regulates ADP dissociation from myosin V Journal of Biological Chemistry. 280: 6072-6079. PMID 15579901 DOI: 10.1074/Jbc.M412717200  0.583
2004 Sweeney HL, Houdusse A. The motor mechanism of myosin V: insights for muscle contraction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 1829-41. PMID 15647159 DOI: 10.1098/Rstb.2004.1576  0.667
2004 Holmes KC, Schröder RR, Sweeney HL, Houdusse A. The structure of the rigor complex and its implications for the power stroke. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 1819-28. PMID 15647158 DOI: 10.1098/Rstb.2004.1566  0.601
2004 Coureux PD, Sweeney HL, Houdusse A. Three myosin V structures delineate essential features of chemo-mechanical transduction Embo Journal. 23: 4527-4537. PMID 15510214 DOI: 10.1038/Sj.Emboj.7600458  0.624
2004 Bahloul A, Chevreux G, Wells AL, Martin D, Nolt J, Yang Z, Chen LQ, Potier N, Van Dorsselaer A, Rosenfeld S, Houdusse A, Sweeney HL. The unique insert in myosin VI is a structural calcium-calmodulin binding site. Proceedings of the National Academy of Sciences of the United States of America. 101: 4787-92. PMID 15037754 DOI: 10.1073/Pnas.0306892101  0.583
2004 Lee S, Barton ER, Sweeney HL, Farrar RP. Viral expression of insulin-like growth factor-I enhances muscle hypertrophy in resistance-trained rats. Journal of Applied Physiology (Bethesda, Md. : 1985). 96: 1097-104. PMID 14766764 DOI: 10.1152/Japplphysiol.00479.2003  0.588
2003 Kobinger GP, Louboutin JP, Barton ER, Sweeney HL, Wilson JM. Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cells. Human Gene Therapy. 14: 1441-9. PMID 14577924 DOI: 10.1089/104303403769211655  0.61
2003 Coureux PD, Wells AL, Ménétrey J, Yengo CM, Morris CA, Sweeney HL, Houdusse A. A structural state of the myosin V motor without bound nucleotide. Nature. 425: 419-23. PMID 14508494 DOI: 10.1038/Nature01927  0.641
2003 Joel PB, Sweeney HL, Trybus KM. Addition of lysines to the 50/20 kDa junction of myosin strengthens weak binding to actin without affecting the maximum ATPase activity Biochemistry. 42: 9160-9166. PMID 12885250 DOI: 10.1021/bi034415j  0.324
2003 Chatterjee S, Bish LT, Jayasankar V, Stewart AS, Woo YJ, Crow MT, Gardner TJ, Sweeney HL. Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain. The Journal of Thoracic and Cardiovascular Surgery. 125: 1461-9. PMID 12830068 DOI: 10.1016/S0022-5223(02)73229-7  0.525
2003 Xiao M, Reifenberger JG, Wells AL, Baldacchino C, Chen LQ, Ge P, Sweeney HL, Selvin PR. An actin-dependent conformational change in myosin. Nature Structural Biology. 10: 402-8. PMID 12679807 DOI: 10.1038/Nsb916  0.321
2002 Barton ER, Morris L, Musaro A, Rosenthal N, Sweeney HL. Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice. The Journal of Cell Biology. 157: 137-48. PMID 11927606 DOI: 10.1083/Jcb.200108071  0.642
2002 Chatterjee S, Jayasankar V, Bish LT, Stewart AS, Woo Y, Crow MT, Gardner TJ, Sweeney H. 05 Viral gene transfer of ARC and BCL-2 confers similar protection against cardiomyopathy after myocardial ischemia Journal of Molecular and Cellular Cardiology. 34: A32. DOI: 10.1016/S0022-2828(02)90181-1  0.513
2001 Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL. Myosin VI is a processive motor with a large step size. Proceedings of the National Academy of Sciences of the United States of America. 98: 13655-9. PMID 11707568 DOI: 10.1073/Pnas.191512398  0.331
2001 De La Cruz EM, Ostap EM, Sweeney HL. Kinetic mechanism and regulation of myosin VI. The Journal of Biological Chemistry. 276: 32373-81. PMID 11423557 DOI: 10.1074/Jbc.M104136200  0.302
2001 Houdusse A, Sweeney HL. Myosin motors: Missing structures and hidden springs Current Opinion in Structural Biology. 11: 182-194. PMID 11297926 DOI: 10.1016/S0959-440X(00)00188-3  0.65
2001 Musarò A, McCullagh K, Paul A, Houghton L, Dobrowolny G, Molinaro M, Barton ER, Sweeney HL, Rosenthal N. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nature Genetics. 27: 195-200. PMID 11175789 DOI: 10.1038/84839  0.636
2000 Sweeney HL, Barton ER. The dystrophin-associated glycoprotein complex: What parts can you do without? Proceedings of the National Academy of Sciences of the United States of America. 97: 13464-13466. PMID 11095702 DOI: 10.1073/Pnas.011510597  0.619
2000 Sweeney HL, Chen LQ, Trybus KM. Regulation of asymmetric smooth muscle myosin II molecules Journal of Biological Chemistry. 275: 41273-41277. PMID 11018047 DOI: 10.1074/jbc.M008310200  0.302
2000 Cordier L, Hack AA, Scott MO, Barton-Davis ER, Gao G, Wilson JM, McNally EM, Sweeney HL. Rescue of skeletal muscles of gamma-sarcoglycan-deficient mice with adeno-associated virus-mediated gene transfer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 119-29. PMID 10933922 DOI: 10.1006/Mthe.1999.0019  0.316
2000 Rosenfeld SS, Xing J, Whitaker M, Cheung HC, Brown F, Wells A, Milligan RA, Sweeney HL. Kinetic and spectroscopic evidence for three actomyosin:ADP states in smooth muscle. The Journal of Biological Chemistry. 275: 25418-26. PMID 10827085 DOI: 10.1074/Jbc.M002685200  0.377
2000 Walter G, Barton ER, Sweeney HL. Noninvasive measurement of gene expression in skeletal muscle Proceedings of the National Academy of Sciences of the United States of America. 97: 5151-5155. PMID 10805778 DOI: 10.1073/Pnas.97.10.5151  0.563
1999 De La Cruz EM, Wells AL, Rosenfeld SS, Ostap EM, Sweeney HL. The kinetic mechanism of myosin V. Proceedings of the National Academy of Sciences of the United States of America. 96: 13726-31. PMID 10570140 DOI: 10.1073/Pnas.96.24.13726  0.307
1999 Wells AL, Lin AW, Chen LQ, Safer D, Cain SM, Hasson T, Carragher BO, Milligan RA, Sweeney HL. Myosin VI is an actin-based motor that moves backwards. Nature. 401: 505-8. PMID 10519557 DOI: 10.1038/46835  0.328
1999 Hack AA, Cordier L, Shoturma DI, Lam MY, Sweeney HL, McNally EM. Muscle degeneration without mechanical injury in sarcoglycan deficiency. Proceedings of the National Academy of Sciences of the United States of America. 96: 10723-8. PMID 10485893 DOI: 10.1073/Pnas.96.19.10723  0.319
1999 Dantzig JA, Barsotti RJ, Manz S, Sweeney HL, Goldman YE. The ADP release step of the smooth muscle cross-bridge cycle is not directly associated with force generation. Biophysical Journal. 77: 386-97. PMID 10388765 DOI: 10.1016/S0006-3495(99)76897-9  0.37
1999 Barton-Davis ER, Shoturma DI, Musaro A, Rosenthal N, Sweeney HL. Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Proceedings of the National Academy of Sciences of the United States of America. 95: 15603-7. PMID 9861016 DOI: 10.1073/Pnas.95.26.15603  0.325
1998 Sweeney HL. Regulation and tuning of smooth muscle myosin American Journal of Respiratory and Critical Care Medicine. 158. PMID 9817731  0.385
1998 Trybus KM, Naroditskaya V, Sweeney HL. The light chain-binding domain of the smooth muscle myosin heavy chain is not the only determinant of regulation Journal of Biological Chemistry. 273: 18423-18428. PMID 9660810 DOI: 10.1074/jbc.273.29.18423  0.377
1997 Trybus KM, Freyzon Y, Faust LZ, Sweeney HL. Spare the rod, spoil the regulation: necessity for a myosin rod. Proceedings of the National Academy of Sciences of the United States of America. 94: 48-52. PMID 8990159 DOI: 10.1073/pnas.94.1.48  0.335
1995 Levine RJC, Kensler RW, Yang Z, Sweeney HL. Myosin regulatory light chain phosphorylation and the production of functionally significant changes in myosin head arrangement on striated muscle thick filaments Biophysical Journal. 68. PMID 7787078  0.315
1995 Sweeney HL, Reggiani C, Lowey S, Rayment I, Schutt C, Chase PB, Cremo C. Function of the N terminus of the myosin essential light chain of vertebrate striated muscle Biophysical Journal. 68: 112s-119s. PMID 7787052  0.574
1995 Yang Z, Sweeney HL. Restoration of phosphorylation-dependent regulation to the skeletal muscle myosin regulatory light chain Journal of Biological Chemistry. 270: 24646-24649. PMID 7559573 DOI: 10.1074/Jbc.270.42.24646  0.31
1995 Whittaker M, Wilson-Kubalek EM, Smith JE, Faust L, Milligan RA, Sweeney HL. A 35-A movement of smooth muscle myosin on ADP release. Nature. 378: 748-51. PMID 7501026 DOI: 10.1038/378748A0  0.318
1994 Sweeney HL, Yang Z, Zhi G, Stull JT, Trybus KM. Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 91: 1490-1494. PMID 8108436 DOI: 10.1073/Pnas.91.4.1490  0.352
1993 Petrof BJ, Shrager JB, Stedman HH, Kelly AM, Sweeney HL. Dystrophin protects the sarcolemma from stresses developed during muscle contraction Proceedings of the National Academy of Sciences of the United States of America. 90: 3710-3714. PMID 8475120 DOI: 10.1073/Pnas.90.8.3710  0.322
1993 Sweeney HL, Bowman BF, Stull JT. Myosin light chain phosphorylation in vertebrate striated muscle: Regulation and function American Journal of Physiology - Cell Physiology. 264. PMID 8388631 DOI: 10.1152/Ajpcell.1993.264.5.C1085  0.346
1991 Stedman HH, Sweeney HL, Shrager JB, Maguire HC, Panettieri RA, Petrof B, Narusawa M, Leferovich JM, Sladky JT, Kelly AM. The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature. 352: 536-9. PMID 1865908 DOI: 10.1038/352536A0  0.312
1990 Stull JT, Bowman BF, Gallagher PJ, Herring BP, Hsu LC, Kamm KE, Kubota Y, Leachman SA, Sweeney HL, Tansey MG. Myosin phosphorylation in smooth and skeletal muscles: regulation and function. Progress in Clinical and Biological Research. 327: 107-26. PMID 2181457  0.324
1990 Sweeney HL, Stull JT. Alteration of cross-bridge kinetics by myosin light chain phosphorylation in rabbit skeletal muscle: Implications for regulation of actin-myosin interaction Proceedings of the National Academy of Sciences of the United States of America. 87: 414-418. PMID 2136951 DOI: 10.1073/Pnas.87.1.414  0.309
1988 Sweeney HL, Kushmerick MJ, Mabuchi K, Sréter FA, Gergely J. Myosin alkali light chain and heavy chain variations correlate with altered shortening velocity of isolated skeletal muscle fibers. The Journal of Biological Chemistry. 263: 9034-9. PMID 3379059  0.535
1987 Sweeney HL, Corteselli SA, Kushmerick MJ. Measurements on permeabilized skeletal muscle fibers during continuous activation. The American Journal of Physiology. 252: C575-80. PMID 3578507 DOI: 10.1152/ajpcell.1987.252.5.C575  0.572
1986 Kushmerick MJ, Dillon PF, Meyer RA, Brown TR, Krisanda JM, Sweeney HL. 31P NMR spectroscopy, chemical analysis, and free Mg2+ of rabbit bladder and uterine smooth muscle. The Journal of Biological Chemistry. 261: 14420-9. PMID 3771537  0.534
1986 Sweeney HL, Kushmerick MJ, Mabuchi K, Gergely J, Sréter FA. Velocity of shortening and myosin isozymes in two types of rabbit fast-twitch muscle fibers. The American Journal of Physiology. 251: C431-4. PMID 3019147 DOI: 10.1152/Ajpcell.1986.251.3.C431  0.569
1985 Sweeney HL, Kushmerick MJ. Myosin phosphorylation in permeabilized rabbit psoas fibers. The American Journal of Physiology. 249: C362-5. PMID 4037077 DOI: 10.1152/ajpcell.1985.249.3.C362  0.55
1985 Sweeney HL, Kushmerick MJ, Mabuchi K, Gergely J, Sreter F. DIFFERENTIAL MYOSIN ISOZYME DISTRIBUTIONS AND SHORTENING VELOCITIES OF RABBIT SKINED SKELETAL MUSCLE FIBERS Medicine & Science in Sports & Exercise. 17: 244. DOI: 10.1249/00005768-198504000-00279  0.592
1984 Meyer RA, Sweeney HL, Kushmerick MJ. A simple analysis of the "phosphocreatine shuttle". The American Journal of Physiology. 246: C365-77. PMID 6372517 DOI: 10.1152/ajpcell.1984.246.5.C365  0.503
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