Timothy Spicer - Publications

Affiliations: 
Chemistry Scripps Research Institute, La Jolla, La Jolla, CA, United States 

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Aziz F, Reddy K, Fernandez Vega V, Dey R, Hicks KA, Rao S, Jordan LO, Smith E, Shumate J, Scampavia L, Carpino N, Spicer TP, French JB. Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins. Journal of Medicinal Chemistry. PMID 38252624 DOI: 10.1021/acs.jmedchem.3c01763  0.323
2023 Coant N, Bickel JD, Rahaim R, Otsuka Y, Choi YM, Xu R, Simoes M, Cariello C, Mao C, Saied EM, Arenz C, Spicer TP, Bannister TD, Tonge PJ, Airola MV, et al. Neutral ceramidase-active site inhibitor chemotypes and binding modes. Bioorganic Chemistry. 139: 106747. PMID 37531819 DOI: 10.1016/j.bioorg.2023.106747  0.345
2023 Smith E, Davis-Gardner ME, Garcia-Ordonez RD, Nguyen TT, Hull M, Chen E, Yu X, Bannister TD, Baillargeon P, Scampavia L, Griffin P, Farzan M, Spicer TP. High Throughput Screening for Drugs that Inhibit 3C-Like Protease in SARS-CoV-2. Slas Discovery : Advancing Life Sciences R & D. PMID 36646172 DOI: 10.1016/j.slasd.2023.01.001  0.338
2023 Liu Z, Chen K, Dai J, Xu P, Sun W, Liu W, Zhao Z, Bennett SP, Li P, Ma T, Lin Y, Kawakami A, Yu J, Wang F, Wang C, ... ... Spicer TP, et al. A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Research. PMID 36588115 DOI: 10.1038/s41422-022-00744-5  0.31
2022 Smith E, Campbell S, Wilson AN, Shumate J, Baillargeon P, Scampavia L, Kamenecka TM, Spicer TP, Solt LA. High Throughput Screening for Compounds to the Orphan Nuclear Receptor NR2F6. Slas Discovery : Advancing Life Sciences R & D. PMID 35331960 DOI: 10.1016/j.slasd.2022.03.005  0.356
2021 Mediouni S, Mou H, Otsuka Y, Jablonski JA, Adcock RS, Batra L, Chung DH, Rood C, de Vera IMS, Rahaim R, Ullah S, Yu X, Getmanenko YA, Kennedy NM, Wang C, ... ... Spicer TP, et al. Identification of potent small molecule inhibitors of SARS-CoV-2 entry. Slas Discovery : Advancing Life Sciences R & D. PMID 35058179 DOI: 10.1016/j.slasd.2021.10.012  0.364
2021 Chulkov EG, Smith E, Rohr CM, Yahya NA, Park SK, Scampavia L, Spicer TP, Marchant JS. Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel. Plos Neglected Tropical Diseases. 15: e0009898. PMID 34731172 DOI: 10.1371/journal.pntd.0009898  0.329
2021 Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, et al. Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay. Bioorganic & Medicinal Chemistry. 42: 116246. PMID 34130216 DOI: 10.1016/j.bmc.2021.116246  0.336
2021 Diez J, Rajendrarao S, Baajour SA, Sripadhan P, Spicer TP, Scampavia LD, Minond D. Development and Pilot Screen of Novel High Content Assay for Down Regulators of Expression of Heterogenous Nuclear Ribonuclear Protein H2. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 55: 265-276. PMID 34014051 DOI: 10.33594/000000372  0.312
2020 Smith E, Davis-Gardner ME, Garcia-Ordonez RD, Nguyen TT, Hull M, Chen E, Baillargeon P, Scampavia L, Strutzenberg T, Griffin P, Farzan M, Spicer TP. High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2. Slas Discovery : Advancing Life Sciences R & D. 2472555220963667. PMID 33043784 DOI: 10.1177/2472555220963667  0.301
2020 Otsuka Y, Airola MV, Choi YM, Coant N, Snider J, Cariello C, Saied EM, Arenz C, Bannister T, Rahaim R, Hannun YA, Shumate J, Scampavia L, Haley JD, Spicer TP. Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. Slas Discovery : Advancing Life Sciences R & D. 2472555220945283. PMID 32734807 DOI: 10.1177/2472555220945283  0.387
2020 Pan CH, Otsuka Y, Sridharan B, Woo M, Leiton CV, Babu S, Torrente Gonçalves M, Kawalerski RR, Bai JDK, Chang DK, Biankin A, Scampavia L, Spicer T, Escobar-Hoyos LF, Shroyer KR. An unbiased high-throughput drug screen reveals a potential therapeutic vulnerability in the most lethal molecular subtype of pancreatic cancer. Molecular Oncology. PMID 32533886 DOI: 10.1002/1878-0261.12743  0.366
2020 Wang L, Cheng CM, Qin J, Xu M, Kao CY, Shi J, You E, Gong W, Rosa LP, Chase P, Scampavia L, Madoux F, Spicer T, Hodder P, Xu HE, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Science Advances. 6: eaaz8031. PMID 32494682 DOI: 10.1126/Sciadv.Aaz8031  0.371
2020 Boca S, Bhuvaneshwar K, Fernandez-Vega V, Kancherla J, Rao S, Madhavan S, Riggins R, Beckman RA, Corrada Bravo H, Scampavia L, Spicer T. Prioritizing targeted therapies in an evidence-based manner, integrating biological context and functional precision medicine. Journal of Clinical Oncology. 38: e14065-e14065. DOI: 10.1200/Jco.2020.38.15_Suppl.E14065  0.345
2019 Sridharan B, Hubbs C, Llamosas N, Kilinc M, Singhera FU, Willems E, Piper DR, Scampavia L, Rumbaugh G, Spicer TP. A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons. Scientific Reports. 9: 9000. PMID 31227747 DOI: 10.1038/S41598-019-45265-1  0.304
2019 Baillargeon P, Fernandez-Vega V, Sridharan BP, Brown S, Griffin PR, Rosen H, Cravatt B, Scampavia L, Spicer TP. The Scripps Molecular Screening Center and Translational Research Institute. Slas Discovery : Advancing Life Sciences R & D. 2472555218820809. PMID 30682260 DOI: 10.1177/2472555218820809  0.315
2019 Pan C, Leiton CV, Roa-Peña L, Kawalerski RR, Moffitt RA, Zhao J, Spicer T, Bailey P, Chang DK, Biankin A, Duong T, Singh PK, Shroyer KR, Escobar-Hoyos LF. Abstract C39: A novel rewired pathway of nucleotide metabolism drives chemoresistance in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-C39  0.338
2018 Zhou W, Yin Y, Smith E, Chou J, Shumate J, Scampavia L, Spicer T, Carpino N, French JB. Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of TCR Signaling Family of Proteins. Acs Infectious Diseases. PMID 30485744 DOI: 10.1021/Acsinfecdis.8B00238  0.368
2018 Nieto A, Fernández-Vega V, Spicer TP, Sturchler E, Adhikari P, Kennedy N, Mandat S, Chase P, Scampavia L, Bannister T, Hodder P, McDonald PH. Identification of Novel, Structurally Diverse, Small Molecule Modulators of GPR119. Assay and Drug Development Technologies. 16: 278-288. PMID 30019946 DOI: 10.1089/Adt.2018.849  0.341
2018 Quereda V, Hou S, Madoux F, Scampavia L, Spicer TP, Duckett D. A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem Cells. Slas Discovery : Advancing Life Sciences R & D. 2472555218775055. PMID 29750582 DOI: 10.1177/2472555218775055  0.337
2018 Wolff RA, Wang-Gillam A, Alvarez H, Tiriac H, Engle D, Hou S, Groff AF, San Lucas A, Bernard V, Allenson K, Castillo J, Kim D, Mulu F, Huang J, Stephens B, ... ... Spicer T, et al. Dynamic changes during the treatment of pancreatic cancer. Oncotarget. 9: 14764-14790. PMID 29599906 DOI: 10.18632/Oncotarget.24483  0.321
2018 Singhera F, Cooper E, Scampavia L, Spicer T. Using bead injection to model dispensing of 3-D multicellular spheroids into microtiter plates. Talanta. 177: 74-76. PMID 29108585 DOI: 10.1016/J.Talanta.2017.09.022  0.306
2017 Kong J, Fang P, Madoux F, Spicer TP, Scampavia L, Kim S, Guo M. High-Throughput Screening for Protein Synthesis Inhibitors Targeting Aminoacyl-tRNA Synthetases. Slas Discovery : Advancing Life Sciences R & D. 2472555217734128. PMID 29020503 DOI: 10.1177/2472555217734128  0.367
2017 Hou S, Madoux F, Scampavia L, Janovick JA, Conn PM, Spicer TP. Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease. Slas Discovery. 2472555217689992. PMID 28346094 DOI: 10.1177/2472555217689992  0.316
2017 Madoux F, Tanner A, Vessels M, Willetts L, Hou S, Scampavia L, Spicer TP. A 1536-Well 3D Viability Assay to Assess the Cytotoxic Effect of Drugs on Spheroids. Slas Discovery. 2472555216686308. PMID 28346088 DOI: 10.1177/2472555216686308  0.335
2016 Madoux F, Dreymuller D, Pettiloud JP, Santos R, Becker-Pauly C, Ludwig A, Fields GB, Bannister T, Spicer TP, Cudic M, Scampavia LD, Minond D. Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate. Scientific Reports. 6: 11. PMID 28442704 DOI: 10.1038/S41598-016-0013-4  0.341
2016 Wang J, Fang P, Chase P, Tshori S, Razin E, Spicer TP, Scampavia L, Hodder P, Guo M. Development of an HTS-Compatible Assay for Discovery of Melanoma-Related Microphthalmia Transcription Factor Disruptors Using AlphaScreen Technology. Journal of Biomolecular Screening. PMID 27827304 DOI: 10.1177/1087057116675274  0.35
2016 Smith E, Janovick JA, Bannister TD, Shumate J, Scampavia L, Conn PM, Spicer TP. Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus. Journal of Biomolecular Screening. PMID 27280550 DOI: 10.1177/1087057116653925  0.325
2016 Thenin-Houssier S, de Vera IM, Pedro-Rosa L, Brady A, Richard A, Konnick B, Opp S, Buffone C, Fuhrmann J, Kota S, Billack B, Pietka-Ottlik M, Tellinghuisen T, Choe H, Spicer T, et al. Ebselen, a small molecule capsid-inhibitor of HIV-1 replication. Antimicrobial Agents and Chemotherapy. PMID 26810656 DOI: 10.1128/Aac.02574-15  0.37
2016 Chase P, Enogieru I, Madoux F, Bishop E, Beer J, Scampavia L, Spicer T. An Automated Miniaturized Method to Perform and Analyze Antimicrobial Drug Synergy Assays. Assay and Drug Development Technologies. 14: 58-66. PMID 26669516 DOI: 10.1089/Adt.2015.672  0.345
2015 Palde PB, Bhaskar A, Pedró Rosa LE, Madoux F, Chase P, Gupta V, Spicer T, Scampavia L, Singh A, Carroll KS. First-In-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis. Acs Chemical Biology. PMID 26524379 DOI: 10.1021/Acschembio.5B00517  0.45
2015 Smith E, Chase P, Niswender CM, Utley TJ, Sheffler DJ, Noetzel MJ, Lamsal A, Wood MR, Conn PJ, Lindsley CW, Madoux F, Acosta M, Scampavia L, Spicer T, Hodder P. Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4). Journal of Biomolecular Screening. PMID 25877150 DOI: 10.1177/1087057115581770  0.328
2015 Ting PY, Damoiseaux R, Titz B, Bradley KA, Graeber TG, Fernández-Vega V, Bannister TD, Chase P, Nair R, Scampavia L, Hodder P, Spicer TP, Colicelli J. Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1. Plos One. 10: e0121833. PMID 25811598 DOI: 10.1371/Journal.Pone.0121833  0.359
2015 Madoux F, Janovick JA, Smithson D, Fargue S, Danpure CJ, Scampavia L, Chen YT, Spicer TP, Conn PM. Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening. Assay and Drug Development Technologies. 13: 16-24. PMID 25710543 DOI: 10.1089/adt.2014.627  0.338
2015 Pedró-Rosa L, Buckner FS, Ranade RM, Eberhart C, Madoux F, Gillespie JR, Koh CY, Brown S, Lohse J, Verlinde CL, Fan E, Bannister T, Scampavia L, Hol WG, Spicer T, et al. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. Journal of Biomolecular Screening. 20: 122-30. PMID 25163684 DOI: 10.1177/1087057114548832  0.465
2014 Kadakkuzha BM, Spicer TP, Chase P, Richman JB, Hodder P, Puthanveettil SV. High-throughput screening for small molecule modulators of motor protein Kinesin. Assay and Drug Development Technologies. 12: 470-80. PMID 25383721 DOI: 10.1089/Adt.2014.579  0.328
2014 Conn PM, Smith E, Spicer T, Chase P, Scampavia L, Janovick JA. A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor. Assay and Drug Development Technologies. 12: 238-46. PMID 24831790 DOI: 10.1089/Adt.2014.576  0.415
2014 Sturchler E, Chen W, Spicer T, Hodder P, McDonald P, Duckett D. Development of an HTS-compatible assay for the discovery of ASK1 signalosome inhibitors using alphascreen technology. Assay and Drug Development Technologies. 12: 229-37. PMID 24831789 DOI: 10.1089/Adt.2013.558  0.444
2014 Spicer T, Fernandez-Vega V, Chase P, Scampavia L, To J, Dalton JP, Da Silva FL, Skinner-Adams TS, Gardiner DL, Trenholme KR, Brown CL, Ghosh P, Porubsky P, Wang JL, Whipple DA, et al. Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening. Journal of Biomolecular Screening. 19: 1107-1115. PMID 24619116 DOI: 10.1177/1087057114525852  0.465
2013 Richard DJ, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorganic & Medicinal Chemistry. 21: 6642-9. PMID 23993674 DOI: 10.1016/J.Bmc.2013.08.017  0.437
2013 Thomas PW, Spicer T, Cammarata M, Brodbelt JS, Hodder P, Fast W. An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening. Bioorganic & Medicinal Chemistry. 21: 3138-46. PMID 23591260 DOI: 10.1016/J.Bmc.2013.03.031  0.447
2013 Karapetyan YE, Sferrazza GF, Zhou M, Ottenberg G, Spicer T, Chase P, Fallahi M, Hodder P, Weissmann C, Lasmézas CI. Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents. Proceedings of the National Academy of Sciences of the United States of America. 110: 7044-9. PMID 23576755 DOI: 10.1073/Pnas.1303510110  0.385
2013 Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorganic & Medicinal Chemistry Letters. 23: 839-43. PMID 23260346 DOI: 10.1016/J.Bmcl.2012.11.061  0.318
2013 Richard DJ, Carlson N, Pierceall W, Lena R, Bannister T, Hodder P, Spicer T, Andreeff M, Opferman J, Koss B, Kung A, Cardone M. Abstract 2466: Characterization and development of on-target Mcl-1 inhibitors; BH3 profiling provides a valuable drug discovery tool. Cancer Research. 73: 2466-2466. DOI: 10.1158/1538-7445.Am2013-2466  0.443
2012 Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. Journal of the American Chemical Society. 134: 10345-8. PMID 22690931 DOI: 10.1021/Ja303400U  0.406
2012 Amundsen SK, Spicer T, Karabulut AC, Londoño LM, Eberhart C, Fernandez Vega V, Bannister TD, Hodder P, Smith GR. Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes. Acs Chemical Biology. 7: 879-91. PMID 22443934 DOI: 10.1021/Cb300018X  0.424
2011 Tsuboi K, Bachovchin DA, Speers AE, Spicer TP, Fernandez-Vega V, Hodder P, Rosen H, Cravatt BF. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance. Journal of the American Chemical Society. 133: 16605-16. PMID 21899313 DOI: 10.1021/Ja2066972  0.362
2011 Bialkowska AB, Crisp M, Bannister T, He Y, Chowdhury S, Schur̈er S, Chase P, Spicer T, Madoux F, Tian C, Hodder P, Zaharevitz D, Yang VW. Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening Molecular Cancer Therapeutics. 10: 2043-2051. PMID 21885866 DOI: 10.1158/1535-7163.Mct-11-0550  0.415
2011 Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF, Saghatelian A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Journal of the American Chemical Society. 133: 11665-74. PMID 21692504 DOI: 10.1021/Ja2036095  0.351
2011 Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 6811-6. PMID 21398589 DOI: 10.1073/Pnas.1015248108  0.368
2010 Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF. Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9). Bioorganic & Medicinal Chemistry Letters. 20: 2254-8. PMID 20207142 DOI: 10.1016/J.Bmcl.2010.02.011  0.369
2010 Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD. A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization. Assay and Drug Development Technologies. 8: 96-105. PMID 20035614 DOI: 10.1089/Adt.2009.0217  0.397
2009 Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P. Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries. Bioorganic & Medicinal Chemistry. 17: 5027-37. PMID 19553129 DOI: 10.1016/J.Bmc.2009.05.070  0.434
2008 Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, et al. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II). Journal of Biomolecular Screening. 13: 17-28. PMID 18227223 DOI: 10.1177/1087057107310806  0.416
2008 Lauer-Fields JL, Spicer TP, Chase PS, Cudic M, Burstein GD, Nagase H, Hodder P, Fields GB. Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. Analytical Biochemistry. 373: 43-51. PMID 17949675 DOI: 10.1016/J.Ab.2007.09.014  0.301
2003 Lin PF, Blair W, Wang T, Spicer T, Guo Q, Zhou N, Gong YF, Wang HG, Rose R, Yamanaka G, Robinson B, Li CB, Fridell R, Deminie C, Demers G, et al. A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding. Proceedings of the National Academy of Sciences of the United States of America. 100: 11013-8. PMID 12930892 DOI: 10.1073/Pnas.1832214100  0.325
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