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James Chmiel, M.D. - Publications

Affiliations: 
CWRU, Cleveland, OH 

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Clougherty JE, Kinnee EJ, Cardet JC, Mauger D, Bacharier L, Beigelman A, Blake KV, Cabana MD, Castro M, Chmiel JF, Covar R, Fitzpatrick A, Gaffin JM, Gentile D, Israel E, et al. Geography, generalisability, and susceptibility in clinical trials. The Lancet. Respiratory Medicine. PMID 33539731 DOI: 10.1016/S2213-2600(21)00046-1  1
2020 Chmiel JF, Flume P, Downey DG, Dozor AJ, Colombo C, Mazurek H, Sapiejka E, Rachel M, Constantine S, Conley B, Dgetluck N, Dinh Q, White B, Elborn JS. Safety and efficacy of lenabasum in a phase 2 randomized, placebo-controlled trial in adults with cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 33011099 DOI: 10.1016/j.jcf.2020.09.008  0.48
2019 Wechsler ME, Szefler SJ, Ortega VE, Pongracic JA, Chinchilli V, Lima JJ, Krishnan JA, Kunselman SJ, Mauger D, Bleecker ER, Bacharier LB, Beigelman A, Benson M, Blake KV, Cabana MD, ... ... Chmiel JF, et al. Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma. The New England Journal of Medicine. 381: 1227-1239. PMID 31553835 DOI: 10.1056/NEJMoa1905560  0.6
2019 Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, ... ... Chmiel J, et al. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. The New England Journal of Medicine. PMID 31112384 DOI: 10.1056/NEJMoa1814917  0.6
2019 Guilbert TW, Bacharier LB, Mauger DT, Phipatanakul W, Szefler SJ, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana MD, Castro M, Chmiel JF, et al. Challenges in Assessing the Efficacy of Systemic Corticosteroids for Severe Wheezing Episodes in Preschool Children. The Journal of Allergy and Clinical Immunology. PMID 30660645 DOI: 10.1016/j.jaci.2018.10.071  0.6
2018 Roesch EA, Nichols DP, Chmiel JF. Inflammation in cystic fibrosis: An update. Pediatric Pulmonology. PMID 29999593 DOI: 10.1002/ppul.24129  1
2018 DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, et al. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. Bmc Pulmonary Medicine. 18: 58. PMID 29631584 DOI: 10.1186/s12890-018-0612-x  0.88
2018 Jackson DJ, Bacharier LB, Mauger DT, Boehmer S, Beigelman A, Chmiel JF, Fitzpatrick AM, Gaffin JM, Morgan WJ, Peters SP, Phipatanakul W, Sheehan WJ, Cabana MD, Holguin F, Martinez FD, et al. Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations. The New England Journal of Medicine. PMID 29504498 DOI: 10.1056/NEJMoa1710988  1
2017 Jain R, Beckett VV, Konstan MW, Accurso FJ, Burns JL, Mayer-Hamblett N, Milla C, VanDevanter DR, Chmiel JF. KB001-A, a novel anti-inflammatory, found to be safe and well-tolerated in cystic fibrosis patients infected with Pseudomonas aeruginosa. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 29292092 DOI: 10.1016/j.jcf.2017.12.006  0.88
2017 Zemanick ET, Wagner BD, Robertson CE, Ahrens RC, Chmiel JF, Clancy JP, Gibson RL, Harris WT, Kurland G, Laguna TA, McColley SA, McCoy K, Retsch-Bogart G, Sobush KT, Zeitlin PL, et al. Airway microbiota across age and disease spectrum in cystic fibrosis. The European Respiratory Journal. 50. PMID 29146601 DOI: 10.1183/13993003.00832-2017  0.48
2017 Polineni D, Dang H, Gallins PJ, Jones LC, Pace RG, Stonebraker JR, Commander LA, Krenicky JE, Zhou YH, Corvol H, Cutting GR, Drumm ML, Strug LJ, Boyle MP, Durie PR, ... Chmiel JF, et al. Airway Mucosal Host Defense is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity. American Journal of Respiratory and Critical Care Medicine. PMID 28853905 DOI: 10.1164/rccm.201701-0134OC  0.4
2017 Bonfield T, Chmiel JF. Impaired innate immune cells in cystic fibrosis: Is it really a surprise? Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 28610881 DOI: 10.1016/j.jcf.2017.06.001  0.32
2017 Donaldson SH, Solomon GM, Zeitlin PL, Flume PA, Casey A, McCoy K, Zemanick ET, Mandagere A, Troha JM, Shoemaker SA, Chmiel JF, Taylor-Cousar JL. Pharmacokinetics and safety of cavosonstat (N91115) in healthy and cystic fibrosis adults homozygous for F508DEL-CFTR. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 28209466 DOI: 10.1016/j.jcf.2017.01.009  0.48
2016 Nichols DP, Happoldt CL, Bratcher PE, Caceres SM, Chmiel JF, Malcolm KC, Saavedra MT, Saiman L, Taylor-Cousar JL, Nick JA. Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 28025037 DOI: 10.1016/j.jcf.2016.12.003  0.48
2016 Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, Moy JN, Paul IM, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF, Martinez FD, Pongracic JA, ... ... Chmiel JF, et al. Individualized Therapy for Persistent Asthma in Young Children. The Journal of Allergy and Clinical Immunology. PMID 27777180 DOI: 10.1016/j.jaci.2016.09.028  1
2016 Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF, Martinez FD, Pongracic JA, ... ... Chmiel JF, et al. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. The New England Journal of Medicine. 375: 619-630. PMID 27532828 DOI: 10.1056/NEJMoa1515990  1
2016 Hsu D, Taylor P, Fletcher D, van Heeckeren R, Eastman J, van Heeckeren A, Davis P, Chmiel JF, Pearlman E, Bonfield T. CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention. Infection and Immunity. PMID 27271746 DOI: 10.1128/IAI.00284-16  0.32
2016 Matuska B, Comhair S, Farver C, Chmiel J, Midura RJ, Bonfield T, Lauer ME. Pathological Hyaluronan Matrices in Cystic Fibrosis Airways and Secretions. American Journal of Respiratory Cell and Molecular Biology. PMID 27243106 DOI: 10.1165/rcmb.2015-0358OC  0.32
2016 Taylor PR, Bonfield TL, Chmiel JF, Pearlman E. Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC. Clinical Immunology (Orlando, Fla.). PMID 27155366 DOI: 10.1016/j.clim.2016.03.016  0.36
2015 Donnola SB, Dasenbrook EC, Weaver D, Lu L, Gupta K, Prabhakaran A, Yu X, Chmiel JF, McBennett K, Konstan MW, Drumm ML, Flask CA. Preliminary comparison of normalized T1 and non-contrast perfusion MRI assessments of regional lung disease in cystic fibrosis patients. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 26719281 DOI: 10.1016/j.jcf.2015.11.009  0.88
2015 MacNee W, Fahy J, Nicod L, Kolls J. Purpose of the Conference: 2015 Transatlantic Airway Conference. Annals of the American Thoracic Society. 12: S111. PMID 26595725 DOI: 10.1513/AnnalsATS.201505-264AW  1
2015 Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, et al. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. Jama. 314: 2034-2044. PMID 26575060 DOI: 10.1001/jama.2015.13896  1
2015 Nichols DP, Chmiel JF. Inflammation and its genesis in cystic fibrosis. Pediatric Pulmonology. 50: S39-56. PMID 26335954 DOI: 10.1002/ppul.23242  1
2015 Gaggar A, Chen J, Chmiel JF, Dorkin HL, Flume PA, Griffin R, Nichols D, Donaldson SH. Inhaled alpha1-proteinase inhibitor therapy in patients with cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 26321218 DOI: 10.1016/j.jcf.2015.07.009  1
2015 Torphy TJ, Allen J, Cantin AM, Konstan MW, Accurso FJ, Joseloff E, Ratjen FA, Chmiel JF. Considerations for the Conduct of Clinical Trials with Anti-inflammatory Agents in Cystic Fibrosis: A Cystic Fibrosis Foundation Workshop Report. Annals of the American Thoracic Society. PMID 26146892 DOI: 10.1513/AnnalsATS.201506-361OT  1
2015 Lee MJ, Alvarez JA, Smith EM, Killilea DW, Chmiel JF, Joseph PM, Grossmann RE, Gaggar A, Ziegler TR, Tangpricha V. Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis. Nutrition in Clinical Practice : Official Publication of the American Society For Parenteral and Enteral Nutrition. PMID 26078287 DOI: 10.1177/0884533615589991  1
2015 Faro A, Wood RE, Schechter MS, Leong AB, Wittkugel E, Abode K, Chmiel JF, Daines C, Davis S, Eber E, Huddleston C, Kilbaugh T, Kurland G, Midulla F, Molter D, et al. Official American Thoracic Society technical standards: flexible airway endoscopy in children. American Journal of Respiratory and Critical Care Medicine. 191: 1066-80. PMID 25932763 DOI: 10.1164/rccm.201503-0474ST  1
2015 Chmiel JF, Konstan MW, Accurso FJ, Lymp J, Mayer-Hamblett N, VanDevanter DR, Rose LM, Ramsey BW. Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 25869324 DOI: 10.1016/j.jcf.2015.03.007  1
2015 Cantin AM, Hartl D, Konstan MW, Chmiel JF. Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 14: 419-30. PMID 25814049 DOI: 10.1016/j.jcf.2015.03.003  1
2015 Sagel SD, Thompson V, Chmiel JF, Montgomery GS, Nasr SZ, Perkett E, Saavedra MT, Slovis B, Anthony MM, Emmett P, Heltshe SL. Effect of treatment of cystic fibrosis pulmonary exacerbations on systemic inflammation. Annals of the American Thoracic Society. 12: 708-17. PMID 25714657 DOI: 10.1513/AnnalsATS.201410-493OC  1
2014 Chmiel JF, Aksamit TR, Chotirmall SH, Dasenbrook EC, Elborn JS, LiPuma JJ, Ranganathan SC, Waters VJ, Ratjen FA. Antibiotic management of lung infections in cystic fibrosis. II. Nontuberculous mycobacteria, anaerobic bacteria, and fungi. Annals of the American Thoracic Society. 11: 1298-306. PMID 25167882 DOI: 10.1513/AnnalsATS.201405-203AS  1
2014 Chmiel JF, Aksamit TR, Chotirmall SH, Dasenbrook EC, Elborn JS, LiPuma JJ, Ranganathan SC, Waters VJ, Ratjen FA. Antibiotic management of lung infections in cystic fibrosis. I. The microbiome, methicillin-resistant Staphylococcus aureus, gram-negative bacteria, and multiple infections. Annals of the American Thoracic Society. 11: 1120-9. PMID 25102221 DOI: 10.1513/AnnalsATS.201402-050AS  1
2014 Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. Jama. 311: 2083-91. PMID 24838406 DOI: 10.1001/jama.2014.5052  1
2014 Szefler SJ, Chmiel JF, Fitzpatrick AM, Giacoia G, Green TP, Jackson DJ, Nielsen HC, Phipatanakul W, Raissy HH. Reply: To PMID 24290281. The Journal of Allergy and Clinical Immunology. 133: 1776-7. PMID 24786239 DOI: 10.1016/j.jaci.2014.03.013  1
2014 Nick JA, Moskowitz SM, Chmiel JF, Forssén AV, Kim SH, Saavedra MT, Saiman L, Taylor-Cousar JL, Nichols DP. Azithromycin may antagonize inhaled tobramycin when targeting Pseudomonas aeruginosa in cystic fibrosis. Annals of the American Thoracic Society. 11: 342-50. PMID 24476418 DOI: 10.1513/AnnalsATS.201310-352OC  1
2014 Szefler SJ, Chmiel JF, Fitzpatrick AM, Giacoia G, Green TP, Jackson DJ, Nielsen HC, Phipatanakul W, Raissy HH. Asthma across the ages: knowledge gaps in childhood asthma. The Journal of Allergy and Clinical Immunology. 133: 3-13; quiz 14. PMID 24290281 DOI: 10.1016/j.jaci.2013.10.018  1
2014 Milla CE, Chmiel JF, Accurso FJ, VanDevanter DR, Konstan MW, Yarranton G, Geller DE. Anti-PcrV antibody in cystic fibrosis: a novel approach targeting Pseudomonas aeruginosa airway infection. Pediatric Pulmonology. 49: 650-8. PMID 24019259 DOI: 10.1002/ppul.22890  1
2013 Chmiel JF, Konstan MW, Elborn JS. Antibiotic and anti-inflammatory therapies for cystic fibrosis. Cold Spring Harbor Perspectives in Medicine. 3: a009779. PMID 23880054 DOI: 10.1101/cshperspect.a009779  1
2012 Ross K, Chmiel JF, Ferkol T. The impact of the Clean Air Act. The Journal of Pediatrics. 161: 781-6. PMID 22920509 DOI: 10.1016/j.jpeds.2012.06.064  1
2012 Wildfire JJ, Gergen PJ, Sorkness CA, Mitchell HE, Calatroni A, Kattan M, Szefler SJ, Teach SJ, Bloomberg GR, Wood RA, Liu AH, Pongracic JA, Chmiel JF, Conroy K, Rivera-Sanchez Y, et al. Development and validation of the Composite Asthma Severity Index--an outcome measure for use in children and adolescents. The Journal of Allergy and Clinical Immunology. 129: 694-701. PMID 22244599 DOI: 10.1016/j.jaci.2011.12.962  1
2011 Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, Gruchalla RS, Kattan M, Teach SJ, Pongracic JA, Chmiel JF, Steinbach SF, Calatroni A, Togias A, Thompson KM, et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. The New England Journal of Medicine. 364: 1005-15. PMID 21410369 DOI: 10.1056/NEJMoa1009705  1
2011 Aujla SJ, Ross KR, Chmiel JF, Holguin F. Airway molecular phenotypes in pediatric asthma. Current Opinion in Allergy and Clinical Immunology. 11: 122-6. PMID 21358402 DOI: 10.1097/ACI.0b013e328344874d  1
2011 Accurso FJ, Moss RB, Wilmott RW, Anbar RD, Schaberg AE, Durham TA, Ramsey BW. Denufosol tetrasodium in patients with cystic fibrosis and normal to mildly impaired lung function. American Journal of Respiratory and Critical Care Medicine. 183: 627-34. PMID 21169471 DOI: 10.1164/rccm.201008-1267OC  1
2010 Matsui EC, Sampson HA, Bahnson HT, Gruchalla RS, Pongracic JA, Teach SJ, Gergen PJ, Bloomberg GR, Chmiel JF, Liu AH, Kattan M, Sorkness CA, Steinbach SF, Story RE, Visness CM, et al. Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma. Allergy. 65: 1414-22. PMID 20560910 DOI: 10.1111/j.1398-9995.2010.02412.x  1
2009 Gruchalla RS, Sampson HA, Matsui E, David G, Gergen PJ, Calatroni A, Brown M, Liu AH, Bloomberg GR, Chmiel JF, Kumar R, Lamm C, Smartt E, Sorkness CA, Steinbach SF, et al. Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: role of predictors in the setting of high adherence. The Journal of Allergy and Clinical Immunology. 124: 213-21, 221.e1. PMID 19615730 DOI: 10.1016/j.jaci.2009.05.036  1
2009 Ross KR, Chmiel JF, Konstan MW. The role of inhaled corticosteroids in the management of cystic fibrosis. Paediatric Drugs. 11: 101-13. PMID 19301932 DOI: 10.2165/00148581-200911020-00002  1
2008 Moskowitz SM, Chmiel JF, Sternen DL, Cheng E, Gibson RL, Marshall SG, Cutting GR. Clinical practice and genetic counseling for cystic fibrosis and CFTR-related disorders. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 10: 851-68. PMID 19092437 DOI: 10.1097/GIM.0b013e31818e55a2  1
2008 Nichols DP, Konstan MW, Chmiel JF. Anti-inflammatory therapies for cystic fibrosis-related lung disease. Clinical Reviews in Allergy & Immunology. 35: 135-53. PMID 18546078 DOI: 10.1007/s12016-008-8081-2  1
2008 Nichols D, Chmiel J, Berger M. Chronic inflammation in the cystic fibrosis lung: alterations in inter- and intracellular signaling. Clinical Reviews in Allergy & Immunology. 34: 146-62. PMID 17960347 DOI: 10.1007/s12016-007-8039-9  1
2007 Sagel SD, Chmiel JF, Konstan MW. Sputum biomarkers of inflammation in cystic fibrosis lung disease. Proceedings of the American Thoracic Society. 4: 406-17. PMID 17652508 DOI: 10.1513/pats.200703-044BR  1
2007 Chmiel JF, Konstan MW. Inflammation and anti-inflammatory therapies for cystic fibrosis. Clinics in Chest Medicine. 28: 331-46. PMID 17467552 DOI: 10.1016/j.ccm.2007.02.002  1
2005 Chmiel JF, Konstan MW. Anti-inflammatory medications for cystic fibrosis lung disease: selecting the most appropriate agent. Treatments in Respiratory Medicine. 4: 255-73. PMID 16086599 DOI: 10.2165/00151829-200504040-00004  1
2003 Chmiel JF, Davis PB. State of the art: why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection? Respiratory Research. 4: 8. PMID 14511398 DOI: 10.1186/1465-9921-4-8  1
2003 Ordoñez CL, Henig NR, Mayer-Hamblett N, Accurso FJ, Burns JL, Chmiel JF, Daines CL, Gibson RL, McNamara S, Retsch-Bogart GZ, Zeitlin PL, Aitken ML. Inflammatory and microbiologic markers in induced sputum after intravenous antibiotics in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 168: 1471-5. PMID 12969869 DOI: 10.1164/rccm.200306-731OC  1
2002 Chmiel JF, Berger M, Konstan MW. The role of inflammation in the pathophysiology of CF lung disease. Clinical Reviews in Allergy & Immunology. 23: 5-27. PMID 12162106 DOI: 10.1385/CRIAI:23:1:005  1
2002 Chmiel JF, Konstan MW, Saadane A, Krenicky JE, Lester Kirchner H, Berger M. Prolonged inflammatory response to acute Pseudomonas challenge in interleukin-10 knockout mice. American Journal of Respiratory and Critical Care Medicine. 165: 1176-81. PMID 11956064 DOI: 10.1164/ajrccm.165.8.2107051  1
2002 Chmiel JF, Konstan MW, Berger M. Murine models of CF airway infection and inflammation. Methods in Molecular Medicine. 70: 495-515. PMID 11917546 DOI: 10.1385/1-59259-187-6:495  1
2002 Soltys J, Bonfield T, Chmiel J, Berger M. Functional IL-10 deficiency in the lung of cystic fibrosis (cftr(-/-)) and IL-10 knockout mice causes increased expression and function of B7 costimulatory molecules on alveolar macrophages. Journal of Immunology (Baltimore, Md. : 1950). 168: 1903-10. PMID 11823525  1
1999 Chmiel JF, Konstan MW, Knesebeck JE, Hilliard JB, Bonfield TL, Dawson DV, Berger M. IL-10 attenuates excessive inflammation in chronic Pseudomonas infection in mice American Journal of Respiratory and Critical Care Medicine. 160: 2040-2047. PMID 10588626  1
1999 Chmiel JF, Drumm ML, Konstan MW, Ferkol TW, Kercsmar CM. Pitfall in the use of genotype analysis as the sole diagnostic criterion for cystic fibrosis. Pediatrics. 103: 823-6. PMID 10103316 DOI: 10.1542/peds.103.4.823  1
1999 Lane JR, Chmiel JF, Zahka KG. Marfan syndrome and asthma: A review Pediatric Asthma, Allergy and Immunology. 13: 181-187.  1
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