Ronald Craig Rubenstein, M.D., Ph.D. - Publications

Affiliations: 
Pediatrics, Division of Pulmonary Medicine Children’s Hospital of Philadelphia / University of Pennsylvania, Philadelphia, PA, United States 
Area:
cystic fibrosis, cell biology
Website:
http://www.chop.edu/doctors/rubenstein-ronald

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Sheikh S, Putt ME, Forde KA, Rubenstein RC, Kelly A. Elevation of one hour plasma glucose during oral glucose tolerance testing. Pediatric Pulmonology. PMID 26087115 DOI: 10.1002/ppul.23237  0.92
2015 Conrad C, Lymp J, Thompson V, Dunn C, Davies Z, Chatfield B, Nichols D, Clancy J, Vender R, Egan ME, Quittell L, Michelson P, Antony V, Spahr J, Rubenstein RC, et al. Long-term treatment with oral N-acetylcysteine: affects lung function but not sputum inflammation in cystic fibrosis subjects. A phase II randomized placebo-controlled trial. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 14: 219-27. PMID 25228446 DOI: 10.1016/j.jcf.2014.08.008  0.92
2014 Adams KM, Abraham V, Spielman D, Kolls JK, Rubenstein RC, Conner GE, Cohen NA, Kreindler JL. IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells. Plos One. 9: e103263. PMID 25141009 DOI: 10.1371/journal.pone.0103263  0.92
2014 Grumbach Y, Bikard Y, Suaud L, Chanoux RA, Rubenstein RC. ERp29 regulates epithelial sodium channel functional expression by promoting channel cleavage. American Journal of Physiology. Cell Physiology. 307: C701-9. PMID 24944201 DOI: 10.1152/ajpcell.00134.2014  0.92
2014 Alexiou S, Rubenstein RC. Seeing is believing: imaging early lung disease in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 189: 883-5. PMID 24735030 DOI: 10.1164/rccm.201403-0422ED  0.92
2014 Millington K, Miller V, Rubenstein RC, Kelly A. Patient and parent perceptions of the diagnosis and management of cystic fibrosis-related diabetes Journal of Clinical and Translational Endocrinology. 1: 100-107. DOI: 10.1016/j.jcte.2014.07.003  0.92
2013 Chanoux RA, Shubin CB, Robay A, Suaud L, Rubenstein RC. Hsc70 negatively regulates epithelial sodium channel trafficking at multiple sites in epithelial cells. American Journal of Physiology. Cell Physiology. 305: C776-87. PMID 23885065 DOI: 10.1152/ajpcell.00059.2013  0.92
2013 Clancy JP, Dupont L, Konstan MW, Billings J, Fustik S, Goss CH, Lymp J, Minic P, Quittner AL, Rubenstein RC, Young KR, Saiman L, Burns JL, Govan JR, Ramsey B, et al. Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection. Thorax. 68: 818-25. PMID 23749840 DOI: 10.1136/thoraxjnl-2012-202230  0.92
2012 Chanoux RA, Rubenstein RC. Molecular Chaperones as Targets to Circumvent the CFTR Defect in Cystic Fibrosis. Frontiers in Pharmacology. 3: 137. PMID 22822398 DOI: 10.3389/fphar.2012.00137  0.92
2012 Mueller GM, Yan W, Copelovitch L, Jarman S, Wang Z, Kinlough CL, Tolino MA, Hughey RP, Kleyman TR, Rubenstein RC. Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity. American Journal of Physiology. Renal Physiology. 303: F220-8. PMID 22573385 DOI: 10.1152/ajprenal.00493.2011  0.92
2012 Liu J, Lu W, Guha S, Baltazar GC, Coffey EE, Laties AM, Rubenstein RC, Reenstra WW, Mitchell CH. Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells. American Journal of Physiology. Cell Physiology. 303: C160-9. PMID 22572847 DOI: 10.1152/ajpcell.00278.2011  0.92
2012 Chanoux RA, Robay A, Shubin CB, Kebler C, Suaud L, Rubenstein RC. Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum. The Journal of Biological Chemistry. 287: 19255-65. PMID 22496374 DOI: 10.1074/jbc.M112.357756  0.92
2012 Arkin LM, Flory JH, Shin DB, Gelfand JM, Treat JR, Allen J, Rubenstein RC, Yan AC. High prevalence of aquagenic wrinkling of the palms in patients with cystic fibrosis and association with measurable increases in transepidermal water loss. Pediatric Dermatology. 29: 560-6. PMID 22471628 DOI: 10.1111/j.1525-1470.2011.01708.x  0.92
2012 Ramsey BW, Banks-Schlegel S, Accurso FJ, Boucher RC, Cutting GR, Engelhardt JF, Guggino WB, Karp CL, Knowles MR, Kolls JK, LiPuma JJ, Lynch S, McCray PB, Rubenstein RC, Singh PK, et al. Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. American Journal of Respiratory and Critical Care Medicine. 185: 887-92. PMID 22312017 DOI: 10.1164/rccm.201111-2068WS  0.92
2012 Clancy JP, Rowe SM, Accurso FJ, Aitken ML, Amin RS, Ashlock MA, Ballmann M, Boyle MP, Bronsveld I, Campbell PW, De Boeck K, Donaldson SH, Dorkin HL, Dunitz JM, Durie PR, ... ... Rubenstein RC, et al. Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax. 67: 12-8. PMID 21825083 DOI: 10.1136/thoraxjnl-2011-200393  0.92
2012 Chanoux RA, Robay A, Shubin CB, Kebler C, Suaud L, Rubenstein RC. Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum (The Journal of Biological Chemistry (2012) 287, (19255-19265)) Journal of Biological Chemistry. 287: 35540. DOI: 10.1074/jbc.A112.357756  0.92
2011 Suaud L, Miller K, Panichelli AE, Randell RL, Marando CM, Rubenstein RC. 4-Phenylbutyrate stimulates Hsp70 expression through the Elp2 component of elongator and STAT-3 in cystic fibrosis epithelial cells. The Journal of Biological Chemistry. 286: 45083-92. PMID 22069317 DOI: 10.1074/jbc.M111.293282  0.92
2011 Suaud L, Miller K, Alvey L, Yan W, Robay A, Kebler C, Kreindler JL, Guttentag S, Hubbard MJ, Rubenstein RC. ERp29 regulates DeltaF508 and wild-type cystic fibrosis transmembrane conductance regulator (CFTR) trafficking to the plasma membrane in cystic fibrosis (CF) and non-CF epithelial cells. The Journal of Biological Chemistry. 286: 21239-53. PMID 21525008 DOI: 10.1074/jbc.M111.240267  0.92
2011 Suratwala D, Chan JS, Kelly A, Meltzer LJ, Gallagher PR, Traylor J, Rubenstein RC, Marcus CL. Nocturnal saturation and glucose tolerance in children with cystic fibrosis. Thorax. 66: 574-8. PMID 21273357 DOI: 10.1136/thx.2010.142141  0.92
2011 Brodsky J, Dougherty S, Makani R, Rubenstein RC, Kelly A. Elevation of 1-hour plasma glucose during oral glucose tolerance testing is associated with worse pulmonary function in cystic fibrosis. Diabetes Care. 34: 292-5. PMID 21228248 DOI: 10.2337/dc10-1604  0.92
2011 Rubenstein RC, Lockwood SR, Lide E, Bauer R, Suaud L, Grumbach Y. Regulation of endogenous ENaC functional expression by CFTR and ΔF508-CFTR in airway epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 300: L88-L101. PMID 20935229 DOI: 10.1152/ajplung.00142.2010  0.92
2010 Accurso FJ, Rowe SM, Clancy JP, Boyle MP, Dunitz JM, Durie PR, Sagel SD, Hornick DB, Konstan MW, Donaldson SH, Moss RB, Pilewski JM, Rubenstein RC, Uluer AZ, Aitken ML, et al. Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. The New England Journal of Medicine. 363: 1991-2003. PMID 21083385 DOI: 10.1056/NEJMoa0909825  0.92
2009 Liou TG, Rubenstein RC. Carrier screening, incidence of cystic fibrosis, and difficult decisions. Jama. 302: 2595-6. PMID 20009063 DOI: 10.1001/jama.2009.1865  0.92
2009 Das S, Smith TD, Sarma JD, Ritzenthaler JD, Maza J, Kaplan BE, Cunningham LA, Suaud L, Hubbard MJ, Rubenstein RC, Koval M. ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum. Molecular Biology of the Cell. 20: 2593-604. PMID 19321666 DOI: 10.1091/mbc.E08-07-0790  0.92
2007 Antunes MB, Woodworth BA, Bhargave G, Xiong G, Aguilar JL, Ratner AJ, Kreindler JL, Rubenstein RC, Cohen NA. Murine nasal septa for respiratory epithelial air-liquid interface cultures. Biotechniques. 43: 195-6, 198, 200 pass. PMID 17824387 DOI: 10.2144/000112493  0.92
2007 Kashlan OB, Mueller GM, Qamar MZ, Poland PA, Ahner A, Rubenstein RC, Hughey RP, Brodsky JL, Kleyman TR. Small heat shock protein alphaA-crystallin regulates epithelial sodium channel expression. The Journal of Biological Chemistry. 282: 28149-56. PMID 17664274 DOI: 10.1074/jbc.M703409200  0.92
2007 Yan W, Spruce L, Rosenblatt MM, Kleyman TR, Rubenstein RC. Intracellular trafficking of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel is modulated by casein kinase 1. American Journal of Physiology. Renal Physiology. 293: F868-76. PMID 17596527 DOI: 10.1152/ajprenal.00194.2007  0.92
2007 Suaud L, Yan W, Carattino MD, Robay A, Kleyman TR, Rubenstein RC. Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC. American Journal of Physiology. Cell Physiology. 292: C1553-61. PMID 17182731 DOI: 10.1152/ajpcell.00064.2006  0.92
2007 Suaud L, Yan W, Rubenstein RC. Abnormal regulatory interactions of I148T-CFTR and the epithelial Na+ channel in Xenopus oocytes. American Journal of Physiology. Cell Physiology. 292: C603-11. PMID 16822950 DOI: 10.1152/ajpcell.00088.2006  0.92
2006 Rubenstein RC. Targeted therapy for cystic fibrosis: cystic fibrosis transmembrane conductance regulator mutation-specific pharmacologic strategies. Molecular Diagnosis & Therapy. 10: 293-301. PMID 17022692  0.92
2006 Raffini LJ, Raybagkar D, Blumenstein MS, Rubenstein RC, Manno CS. Cystic fibrosis as a risk factor for recurrent venous thrombosis at a pediatric tertiary care hospital. The Journal of Pediatrics. 148: 659-64. PMID 16737881 DOI: 10.1016/j.jpeds.2005.11.032  0.92
2006 Goldfarb SB, Kashlan OB, Watkins JN, Suaud L, Yan W, Kleyman TR, Rubenstein RC. Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels. Proceedings of the National Academy of Sciences of the United States of America. 103: 5817-22. PMID 16585520 DOI: 10.1073/pnas.0507903103  0.92
2006 Belkin RA, Henig NR, Singer LG, Chaparro C, Rubenstein RC, Xie SX, Yee JY, Kotloff RM, Lipson DA, Bunin GR. Risk factors for death of patients with cystic fibrosis awaiting lung transplantation. American Journal of Respiratory and Critical Care Medicine. 173: 659-66. PMID 16387803 DOI: 10.1164/rccm.200410-1369OC  0.92
2006 Yan W, Suaud L, Kleyman TR, Rubenstein RC. Differential modulation of a polymorphism in the COOH terminus of the alpha-subunit of the human epithelial sodium channel by protein kinase Cdelta. American Journal of Physiology. Renal Physiology. 290: F279-88. PMID 16174865 DOI: 10.1152/ajprenal.00277.2005  0.92
2005 Rubenstein RC. Novel, mechanism-based therapies for cystic fibrosis. Current Opinion in Pediatrics. 17: 385-92. PMID 15891431 DOI: 10.1097/01.mop.0000158846.95469.6f  0.92
2004 Samaha FF, Rubenstein RC, Yan W, Ramkumar M, Levy DI, Ahn YJ, Sheng S, Kleyman TR. Functional polymorphism in the carboxyl terminus of the alpha-subunit of the human epithelial sodium channel. The Journal of Biological Chemistry. 279: 23900-7. PMID 15069064 DOI: 10.1074/jbc.M401941200  0.92
2004 Yan W, Samaha FF, Ramkumar M, Kleyman TR, Rubenstein RC. Cystic fibrosis transmembrane conductance regulator differentially regulates human and mouse epithelial sodium channels in Xenopus oocytes. The Journal of Biological Chemistry. 279: 23183-92. PMID 15047694 DOI: 10.1074/jbc.M402373200  0.92
2002 Suaud L, Carattino M, Kleyman TR, Rubenstein RC. Genistein improves regulatory interactions between G551D-cystic fibrosis transmembrane conductance regulator and the epithelial sodium channel in Xenopus oocytes. The Journal of Biological Chemistry. 277: 50341-7. PMID 12386156 DOI: 10.1074/jbc.M209641200  0.92
2002 Zeitlin PL, Diener-West M, Rubenstein RC, Boyle MP, Lee CK, Brass-Ernst L. Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 119-26. PMID 12095312 DOI: 10.1006/mthe.2002.0639  0.92
2002 Suaud L, Li J, Jiang Q, Rubenstein RC, Kleyman TR. Genistein restores functional interactions between Delta F508-CFTR and ENaC in Xenopus oocytes. The Journal of Biological Chemistry. 277: 8928-33. PMID 11773060 DOI: 10.1074/jbc.M111482200  0.92
2001 Rubenstein RC, Lyons BM. Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L43-51. PMID 11404244  0.92
2000 Callen A, Diener-West M, Zeitlin PL, Rubenstein RC. A simplified cyclic adenosine monophosphate-mediated sweat rate test for quantitative measure of cystic fibrosis transmembrane regulator (CFTR) function. The Journal of Pediatrics. 137: 849-55. PMID 11113843 DOI: 10.1067/mpd.2000.109198  0.92
2000 Wang X, Moylan B, Leopold DA, Kim J, Rubenstein RC, Togias A, Proud D, Zeitlin PL, Cutting GR. Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population. Jama. 284: 1814-9. PMID 11025834  0.92
2000 Rubenstein RC, Zeitlin PL. Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. American Journal of Physiology. Cell Physiology. 278: C259-67. PMID 10666020  0.92
1998 Rubenstein RC, Zeitlin PL. Use of protein repair therapy in the treatment of cystic fibrosis. Current Opinion in Pediatrics. 10: 250-5. PMID 9716885 DOI: 10.1097/00008480-199806000-00005  0.92
1998 Rubenstein RC, Zeitlin PL. A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function. American Journal of Respiratory and Critical Care Medicine. 157: 484-90. PMID 9476862 DOI: 10.1164/ajrccm.157.2.9706088  0.92
1998 Rubenstein RC, Zeitlin PL, Bargon J. A pilot clinical trial of oral sodium 4-phenylbutyrat (Buphenyl) in AF508-homozygous cystic fibrosis patients | Eine klinische Pilotstudie zur Behandlung der ΔF508-homozygoten zystischen Fibrose mit Natrium 4-Phenvlbutyrat Pneumologie. 52: 417.  0.92
1998 Zeitlin PL, Rubenstein RC, Boyle MP, Chu S. Phenylbutyrate therapy for cystic fibrosis: Basic mechanics and clinical applications Pediatric Pulmonology. 26: 164-167.  0.92
1997 Rubenstein RC, Egan ME, Zeitlin PL. In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR. The Journal of Clinical Investigation. 100: 2457-65. PMID 9366560 DOI: 10.1172/JCI119788  0.92
1997 Rubenstein RC, McVeigh U, Flotte TR, Guggino WB, Zeitlin PL. CFTR gene transduction in neonatal rabbits using an adeno-associated virus (AAV) vector. Gene Therapy. 4: 384-92. PMID 9274714 DOI: 10.1038/sj.gt.3300417  0.92
1991 Rubenstein RC, Linder ME, Ross EM. Selectivity of the beta-adrenergic receptor among Gs, Gi's, and Go: assay using recombinant alpha subunits in reconstituted phospholipid vesicles. Biochemistry. 30: 10769-77. PMID 1657154  0.92
1988 Ross EM, Wong SK, Rubenstein RC, Higashijima T. Functional domains in the beta-adrenergic receptor. Cold Spring Harbor Symposia On Quantitative Biology. 53: 499-506. PMID 2855489  0.92
1987 Rubenstein RC, Wong SK, Ross EM. The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols. The Journal of Biological Chemistry. 262: 16655-62. PMID 2890639  0.92
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