Terrence Flotte - Publications

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155 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Loring HS, ElMallah MK, Flotte TR. Development of RAAV2-CFTR: History of the First RAAV Vector Product to be Used in Humans. Human Gene Therapy Methods. PMID 26895204 DOI: 10.1089/hgtb.2015.150  1
2015 Flotte TR. The End of the Beginning of Gene Therapy. Human Gene Therapy. 26: 407-8. PMID 26176429 DOI: 10.1089/hum.2015.29003.trf  1
2015 Gruntman AM, Flotte TR. Progress with Recombinant Adeno-Associated Virus Vectors for Gene Therapy of Alpha-1 Antitrypsin Deficiency. Human Gene Therapy Methods. 26: 77-81. PMID 26067712 DOI: 10.1089/hgtb.2015.086  1
2015 Flotte TR. Therapeutic Germ Line Alteration: Has CRISPR/Cas9 Technology Forced the Question? Human Gene Therapy. 26: 245-6. PMID 25927157 DOI: 10.1089/hum.2015.28999.tfl  1
2015 Gruntman AM, Su L, Su Q, Gao G, Mueller C, Flotte TR. Stability and compatibility of recombinant adeno-associated virus under conditions commonly encountered in human gene therapy trials. Human Gene Therapy Methods. 26: 71-6. PMID 25819833 DOI: 10.1089/hgtb.2015.040  1
2015 Loring HS, Flotte TR. Current status of gene therapy for α-1 antitrypsin deficiency. Expert Opinion On Biological Therapy. 15: 329-36. PMID 25363251 DOI: 10.1517/14712598.2015.978854  1
2014 Flotte TR, Mueller C. What is suppression of anti-adeno-associated virus capsid T-cells achieving? Human Gene Therapy. 25: 178-9. PMID 24628440 DOI: 10.1089/hum.2014.2506  1
2013 Mueller C, Chulay JD, Trapnell BC, Humphries M, Carey B, Sandhaus RA, McElvaney NG, Messina L, Tang Q, Rouhani FN, Campbell-Thompson M, Fu AD, Yachnis A, Knop DR, Ye GJ, ... ... Flotte TR, et al. Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression. The Journal of Clinical Investigation. 123: 5310-8. PMID 24231351 DOI: 10.1172/JCI70314  1
2013 Flotte TR. Birth of a new therapeutic platform: 47 years of adeno-associated virus biology from virus discovery to licensed gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1976-81. PMID 24201212 DOI: 10.1038/mt.2013.226  1
2013 Ahmed SS, Li H, Cao C, Sikoglu EM, Denninger AR, Su Q, Eaton S, Liso Navarro AA, Xie J, Szucs S, Zhang H, Moore C, Kirschner DA, Seyfried TN, Flotte TR, et al. A single intravenous rAAV injection as late as P20 achieves efficacious and sustained CNS Gene therapy in Canavan mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 2136-47. PMID 23817205 DOI: 10.1038/mt.2013.138  1
2013 Zhong L, Malani N, Li M, Brady T, Xie J, Bell P, Li S, Jones H, Wilson JM, Flotte TR, Bushman FD, Gao G. Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction. Human Gene Therapy. 24: 520-5. PMID 23621841 DOI: 10.1089/hum.2012.112  1
2013 Mueller C, Flotte TR. Gene-based therapy for alpha-1 antitrypsin deficiency. Copd. 10: 44-9. PMID 23527792 DOI: 10.3109/15412555.2013.764978  1
2013 Gruntman AM, Bish LT, Mueller C, Sweeney HL, Flotte TR, Gao G. Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus. Current Protocols in Microbiology. Unit 14D.3. PMID 23408131 DOI: 10.1002/9780471729259.mc14d03s28  1
2013 Bickford JS, Mueller C, Newsom KJ, Barilovits SJ, Beachy DE, Herlihy JD, Keeler B, Flotte TR, Nick HS. Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 12: 258-65. PMID 22985691 DOI: 10.1016/j.jcf.2012.08.014  1
2012 Bouchecareilh M, Hutt DM, Szajner P, Flotte TR, Balch WE. Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency. The Journal of Biological Chemistry. 287: 38265-78. PMID 22995909 DOI: 10.1074/jbc.M112.404707  1
2012 Gruntman AM, Mueller C, Flotte TR, Gao G. Gene transfer in the lung using recombinant adeno-associated virus. Current Protocols in Microbiology. Unit14D.2. PMID 22875566 DOI: 10.1002/9780471729259.mc14d02s26  1
2012 Keeler AM, Flotte TR. Cell and gene therapy for genetic diseases: inherited disorders affecting the lung and those mimicking sudden infant death syndrome. Human Gene Therapy. 23: 548-56. PMID 22642257 DOI: 10.1089/hum.2012.087  1
2012 Keeler AM, Conlon T, Walter G, Zeng H, Shaffer SA, Dungtao F, Erger K, Cossette T, Tang Q, Mueller C, Flotte TR. Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1131-8. PMID 22395529 DOI: 10.1038/mt.2012.39  1
2012 Xie J, Ameres SL, Friedline R, Hung JH, Zhang Y, Xie Q, Zhong L, Su Q, He R, Li M, Li H, Mu X, Zhang H, Broderick JA, Kim JK, ... ... Flotte TR, et al. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nature Methods. 9: 403-9. PMID 22388288 DOI: 10.1038/nmeth.1903  1
2012 Mueller C, Tang Q, Gruntman A, Blomenkamp K, Teckman J, Song L, Zamore PD, Flotte TR. Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 590-600. PMID 22252449 DOI: 10.1038/mt.2011.292  1
2012 Lockett AD, Van Demark M, Gu Y, Schweitzer KS, Sigua N, Kamocki K, Fijalkowska I, Garrison J, Fisher AJ, Serban K, Wise RA, Flotte TR, Mueller C, Presson RG, Petrache HI, et al. Effect of cigarette smoke exposure and structural modifications on the α-1 Antitrypsin interaction with caspases. Molecular Medicine (Cambridge, Mass.). 18: 445-54. PMID 22245800 DOI: 10.2119/molmed.2011.00207  1
2012 Bickford JS, Newsom KJ, Herlihy JD, Mueller C, Keeler B, Qiu X, Walters JN, Su N, Wallet SM, Flotte TR, Nick HS. Induction of group IVC phospholipase A2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells. The Biochemical Journal. 442: 127-37. PMID 22082005 DOI: 10.1042/BJ20111269  1
2012 Keeler AM, Conlon T, Walter G, Zeng H, Shaffer SA, Dungtao F, Erger K, Cossette T, Tang Q, Mueller C, Flotte TR. Long-term correction of very long-chain acyl-CoA dehydrogenase deficiency in mice using AAV9 gene therapy (Molecular Therapy (2012) 20, (1131-1138) DOI: 10.1038/mt.2012.39) Molecular Therapy. 20: 1287. DOI: 10.1038/mt.2012.106  1
2011 Flotte TR, Conlon TJ, Mueller C. Preclinical study design for rAAV. Methods in Molecular Biology (Clifton, N.J.). 807: 317-37. PMID 22034037 DOI: 10.1007/978-1-61779-370-7_14  1
2011 Ettinger WH, Flotte TR. The role of gene and cell therapy in the era of health care reform. Human Gene Therapy. 22: 1307-9. PMID 22023350 DOI: 10.1089/hum.2011.2526  1
2011 Marella M, Seo BB, Flotte TR, Matsuno-Yagi A, Yagi T. No immune responses by the expression of the yeast Ndi1 protein in rats. Plos One. 6: e25910. PMID 21991386 DOI: 10.1371/journal.pone.0025910  1
2011 Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, Campbell-Thompson M, Yachnis AT, Sandhaus RA, McElvaney NG, Mueller C, Messina LM, Wilson JM, Brantly M, Knop DR, et al. Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results. Human Gene Therapy. 22: 1239-47. PMID 21609134 DOI: 10.1089/hum.2011.053  1
2011 Flotte TR, Frederickson RM, Lowenstein PR, Mueller C. Moving forward toward a cure for Parkinson's: neuropathology of the nigrostriatal pathway determines the location of growth factor delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 827-9. PMID 21532611 DOI: 10.1038/mt.2011.76  1
2011 Flotte TR, Mueller C. Gene therapy for alpha-1 antitrypsin deficiency. Human Molecular Genetics. 20: R87-92. PMID 21498872 DOI: 10.1093/hmg/ddr156  1
2011 Chen KA, Cruz PE, Lanuto DJ, Flotte TR, Borchelt DR, Srivastava A, Zhang J, Steindler DA, Zheng T. Cellular fusion for gene delivery to SCA1 affected Purkinje neurons. Molecular and Cellular Neurosciences. 47: 61-70. PMID 21420496 DOI: 10.1016/j.mcn.2011.03.003  1
2011 Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q, He R, Mu X, Seher Ahmed S, Park S, Kato H, Li C, Mueller C, Mello CC, Weng Z, ... Flotte TR, et al. MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 526-35. PMID 21179009 DOI: 10.1038/mt.2010.279  1
2011 Silver JN, Elder M, Conlon T, Cruz P, Wright AJ, Srivastava A, Flotte TR. Recombinant adeno-associated virus-mediated gene transfer for the potential therapy of adenosine deaminase-deficient severe combined immune deficiency. Human Gene Therapy. 22: 935-49. PMID 21142972 DOI: 10.1089/hum.2010.121  1
2011 Flotte TR. Sendai virus vectors. Pushing the envelope in the lung. Gene Therapy. 18: 107-8. PMID 20927135 DOI: 10.1038/gt.2010.132  1
2011 Chulay JD, Ye GJ, Thomas DL, Knop DR, Benson JM, Hutt JA, Wang G, Humphries M, Flotte TR. Preclinical evaluation of a recombinant adeno-associated virus vector expressing human alpha-1 antitrypsin made using a recombinant herpes simplex virus production method. Human Gene Therapy. 22: 155-65. PMID 20812844 DOI: 10.1089/hum.2010.118  1
2011 Mueller C, Braag SA, Keeler A, Hodges C, Drumm M, Flotte TR. Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses. American Journal of Respiratory Cell and Molecular Biology. 44: 922-9. PMID 20724552 DOI: 10.1165/rcmb.2010-0224OC  1
2011 Martino AT, Mueller C, Braag S, Cruz PE, Campbell-Thompson M, Jin S, Flotte TR. N-glycosylation augmentation of the cystic fibrosis epithelium improves Pseudomonas aeruginosa clearance. American Journal of Respiratory Cell and Molecular Biology. 44: 824-30. PMID 20693405 DOI: 10.1165/rcmb.2009-0285OC  1
2011 Mueller C, Kaushal S, Humphries M, Flotte TR. New recombinant adeno-associated virus (rAAV)-based therapeutics reach pivotal phase 2 clinical trials Gene Therapy and Regulation. 6: 71-74. DOI: 10.1142/S1568558611000295  1
2010 Lock M, McGorray S, Auricchio A, Ayuso E, Beecham EJ, Blouin-Tavel V, Bosch F, Bose M, Byrne BJ, Caton T, Chiorini JA, Chtarto A, Clark KR, Conlon T, Darmon C, ... ... Flotte TR, et al. Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material. Human Gene Therapy. 21: 1273-85. PMID 20486768 DOI: 10.1089/hum.2009.223  1
2010 Buff SM, Yu H, McCall JN, Caldwell SM, Ferkol TW, Flotte TR, Virella-Lowell IL. IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia. Gene Therapy. 17: 567-76. PMID 20357828 DOI: 10.1038/gt.2010.28  1
2010 Mueller C, Keeler A, Braag S, Menz T, Tang Q, Flotte TR. Modulation of exaggerated-IgE allergic responses by gene transfer-mediated antagonism of IL-13 and IL-17e. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 511-8. PMID 19935781 DOI: 10.1038/mt.2009.264  1
2010 Mueller C, Strayer MS, Sirninger J, Braag S, Branco F, Louboutin JP, Flotte TR, Strayer DS. In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors. Gene Therapy. 17: 227-37. PMID 19890354 DOI: 10.1038/gt.2009.137  1
2010 Flotte TR, Fischer AC, Goetzmann J, Mueller C, Cebotaru L, Yan Z, Wang L, Wilson JM, Guggino WB, Engelhardt JF. Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 594-600. PMID 19826405 DOI: 10.1038/mt.2009.230  1
2010 Mueller C, Flotte TR. Interfacing Stem Cells with Gene Therapy Human Stem Cell Technology and Biology: a Research Guide and Laboratory Manual. 367-375. DOI: 10.1002/9780470889909.ch30  1
2009 Brantly ML, Chulay JD, Wang L, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proceedings of the National Academy of Sciences of the United States of America. 106: 16363-8. PMID 19706466 DOI: 10.1073/pnas.0904514106  1
2009 Stalvey MS, Flotte TR. Endocrine parameters of cystic fibrosis: back to basics. Journal of Cellular Biochemistry. 108: 353-61. PMID 19670266 DOI: 10.1002/jcb.22284  1
2009 Yu H, Zeidan YH, Wu BX, Jenkins RW, Flotte TR, Hannun YA, Virella-Lowell I. Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. American Journal of Respiratory Cell and Molecular Biology. 41: 367-75. PMID 19168701 DOI: 10.1165/rcmb.2008-0295OC  1
2009 Pashuck TD, Franz SE, Altman MK, Wasserfall CH, Atkinson MA, Wronski TJ, Flotte TR, Stalvey MS. Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation. Pediatric Research. 65: 311-6. PMID 19047917 DOI: 10.1203/PDR.0b013e3181961e80  1
2009 Liqun Wang R, McLaughlin T, Cossette T, Tang Q, Foust K, Campbell-Thompson M, Martino A, Cruz P, Loiler S, Mueller C, Flotte TR. Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 81-7. PMID 18941444 DOI: 10.1038/mt.2008.217  1
2009 Mueller C, Braag SA, Martino AT, Tang Q, Campbell-Thompson M, Flotte TR. The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model. Gene Therapy. 16: 172-83. PMID 18818669 DOI: 10.1038/gt.2008.156  1
2009 Brantly ML, Chulay JD, Lili W, Mueller C, Humphries M, Spencer LT, Rouhani F, Conlon TJ, Calcedo R, Betts MR, Spencer C, Byrne BJ, Wilson JM, Flotte TR. Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 38, (16363-16368) DOI: 10.1073/pnas.0904514106) Proceedings of the National Academy of Sciences of the United States of America. 106: 17605. DOI: 10.1073/pnas.0909220106  1
2008 Cideciyan AV, Aleman TS, Boye SL, Schwartz SB, Kaushal S, Roman AJ, Pang JJ, Sumaroka A, Windsor EA, Wilson JM, Flotte TR, Fishman GA, Heon E, Stone EM, Byrne BJ, et al. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proceedings of the National Academy of Sciences of the United States of America. 105: 15112-7. PMID 18809924 DOI: 10.1073/pnas.0807027105  1
2008 Stalvey MS, Brusko TM, Mueller C, Wasserfall CH, Schatz DA, Atkinson MA, Flotte TR. CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes. Cytokine. 44: 154-9. PMID 18778952 DOI: 10.1016/j.cyto.2008.07.468  1
2008 Hauswirth WW, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L, Conlon TJ, Boye SL, Flotte TR, Byrne BJ, Jacobson SG. Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Human Gene Therapy. 19: 979-90. PMID 18774912 DOI: 10.1089/hum.2008.107  1
2008 Beattie SG, Goetzman E, Tang Q, Conlon T, Campbell-Thompson M, Matern D, Vockley J, Flotte TR. Recombinant adeno-associated virus-mediated gene delivery of long chain acyl coenzyme A dehydrogenase (LCAD) into LCAD-deficient mice. The Journal of Gene Medicine. 10: 1113-23. PMID 18720429 DOI: 10.1002/jgm.1242  1
2008 Mueller C, Flotte TR. Gene therapy for cystic fibrosis. Clinical Reviews in Allergy & Immunology. 35: 164-78. PMID 18600482 DOI: 10.1007/s12016-008-8080-3  1
2008 Silver JN, Flotte TR. Towards a rAAV-based gene therapy for ADA-SCID: from ADA deficiency to current and future treatment strategies. Pharmacogenomics. 9: 947-68. PMID 18597656 DOI: 10.2217/14622416.9.7.947  1
2008 Flotte TR, Goetzmann J, Caridi J, Paolillo J, Conlon TJ, Potter M, Mueller C, Byrne BJ. Apparently nonspecific enzyme elevations after portal vein delivery of recombinant adeno-associated virus serotype 2 vector in hepatitis C virus-infected chimpanzees. Human Gene Therapy. 19: 681-9. PMID 18588426 DOI: 10.1089/hum.2007.174  1
2008 Cebotaru L, Vij N, Ciobanu I, Wright J, Flotte T, Guggino WB. Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing. The Journal of Biological Chemistry. 283: 21926-33. PMID 18508776 DOI: 10.1074/jbc.M709156200  1
2008 Beattie SG, Goetzman E, Conlon T, Germain S, Walter G, Campbell-Thompson M, Matern D, Vockley J, Flotte TR. Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD. Human Gene Therapy. 19: 579-88. PMID 18500942 DOI: 10.1089/hum.2007.168  1
2008 Flotte TR. In utero efficacy of cystic fibrosis gene therapy: difficult studies, positive or negative. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 806-7. PMID 18432269 DOI: 10.1038/mt.2008.53  1
2008 Mueller C, Flotte TR. Clinical gene therapy using recombinant adeno-associated virus vectors. Gene Therapy. 15: 858-63. PMID 18418415 DOI: 10.1038/gt.2008.68  1
2008 Foust KD, Flotte TR, Reier PJ, Mandel RJ. Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat. Human Gene Therapy. 19: 71-82. PMID 18072858 DOI: 10.1089/hum.2007.104  1
2008 Foust KD, Poirier A, Pacak CA, Mandel RJ, Flotte TR. Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons. Human Gene Therapy. 19: 61-70. PMID 18052722 DOI: 10.1089/hum.2007.093  1
2008 Mueller C, Torrez D, Braag S, Martino A, Clarke T, Campbell-Thompson M, Flotte TR. Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene. The Journal of Gene Medicine. 10: 51-60. PMID 18023072 DOI: 10.1002/jgm.1119  1
2008 Embury JE, Frost S, Charron CE, Madrigal E, Perera O, Poirier AE, Zori AG, Carmical R, Flotte TR, Laipis PJ. Hepatitis Virus Protein X-Phenylalanine Hydroxylase fusion proteins identified in PKU mice treated with AAV-WPRE vectors Gene Therapy and Molecular Biology. 12: 69-76.  1
2007 Cruz PE, Mueller C, Flotte TR. The promise of gene therapy for the treatment of alpha-1 antitrypsin deficiency. Pharmacogenomics. 8: 1191-8. PMID 17924834 DOI: 10.2217/14622416.8.9.1191  1
2007 Cruz PE, Mueller C, Cossette TL, Golant A, Tang Q, Beattie SG, Brantly M, Campbell-Thompson M, Blomenkamp KS, Teckman JH, Flotte TR. In vivo post-transcriptional gene silencing of alpha-1 antitrypsin by adeno-associated virus vectors expressing siRNA. Laboratory Investigation; a Journal of Technical Methods and Pathology. 87: 893-902. PMID 17592477 DOI: 10.1038/labinvest.3700629  1
2007 Flotte TR. Gene therapy: the first two decades and the current state-of-the-art. Journal of Cellular Physiology. 213: 301-5. PMID 17577203 DOI: 10.1002/jcp.21173  1
2007 Erger KE, Conlon TJ, Leal NA, Zori R, Bobik TA, Flotte TR. In vivo expression of human ATP:cob(I)alamin adenosyltransferase (ATR) using recombinant adeno-associated virus (rAAV) serotypes 2 and 8. The Journal of Gene Medicine. 9: 462-9. PMID 17471589 DOI: 10.1002/jgm.1040  1
2007 Chen B, Kapturczak MH, Joseph R, George JF, Campbell-Thompson M, Wasserfall CH, Atkinson MA, Tisher CC, Flotte TR, Agarwal A, Chen S. Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7: 1112-20. PMID 17456199 DOI: 10.1111/j.1600-6143.2007.01772.x  1
2007 Flotte TR, Conlon TJ, Poirier A, Campbell-Thompson M, Byrne BJ. Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites. Human Gene Therapy. 18: 245-56. PMID 17376008 DOI: 10.1089/hum.2006.113  1
2007 Fischer AC, Smith CI, Cebotaru L, Zhang X, Askin FB, Wright J, Guggino SE, Adams RJ, Flotte T, Guggino WB. Expression of a truncated cystic fibrosis transmembrane conductance regulator with an AAV5-pseudotyped vector in primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 756-63. PMID 17299412 DOI: 10.1038/sj.mt.6300059  1
2007 Flotte TR, Ng P, Dylla DE, McCray PB, Wang G, Kolls JK, Hu J. Viral vector-mediated and cell-based therapies for treatment of cystic fibrosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 229-41. PMID 17235299 DOI: 10.1038/sj.mt.6300002  1
2006 Brantly ML, Spencer LT, Humphries M, Conlon TJ, Spencer CT, Poirier A, Garlington W, Baker D, Song S, Berns KI, Muzyczka N, Snyder RO, Byrne BJ, Flotte TR. Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alphal-antitrypsin (AAT) vector in AAT-deficient adults. Human Gene Therapy. 17: 1177-86. PMID 17115945 DOI: 10.1089/hum.2006.17.1177  1
2006 Petrache I, Fijalkowska I, Medler TR, Skirball J, Cruz P, Zhen L, Petrache HI, Flotte TR, Tuder RM. alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. The American Journal of Pathology. 169: 1155-66. PMID 17003475 DOI: 10.2353/ajpath.2006.060058  1
2006 Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, Mahoney JH, Levkoff LH, Maier SF, Cruz PE, Flotte TR, Johnson KW, Mahoney MM, Chavez RA, Leinwand LA, et al. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain. 126: 294-308. PMID 16949747 DOI: 10.1016/j.pain.2006.07.009  1
2006 Jacobson SG, Boye SL, Aleman TS, Conlon TJ, Zeiss CJ, Roman AJ, Cideciyan AV, Schwartz SB, Komaromy AM, Doobrajh M, Cheung AY, Sumaroka A, Pearce-Kelling SE, Aguirre GD, Kaushal S, ... ... Flotte TR, et al. Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Human Gene Therapy. 17: 845-58. PMID 16942444 DOI: 10.1089/hum.2006.17.845  1
2006 Flotte TR, Frentzen B, Humphries MR, Rosenbloom AL. Recent developments in the protection of pediatric research subjects. The Journal of Pediatrics. 149: 285-286. PMID 16939731 DOI: 10.1016/j.jpeds.2006.04.033  1
2006 Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L. IL-10 regulation of lupus in the NZM2410 murine model. Laboratory Investigation; a Journal of Technical Methods and Pathology. 86: 1136-48. PMID 16924244 DOI: 10.1038/labinvest.3700468  1
2006 Stalvey MS, Muller C, Schatz DA, Wasserfall CH, Campbell-Thompson ML, Theriaque DW, Flotte TR, Atkinson MA. Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury. Diabetes. 55: 1939-45. PMID 16804061 DOI: 10.2337/db05-1647  1
2006 Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Schwartz SB, Cideciyan AV, Zeiss CJ, Komaromy AM, Kaushal S, Roman AJ, Windsor EA, Sumaroka A, Pearce-Kelling SE, Conlon TJ, Chiodo VA, ... ... Flotte TR, et al. Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1074-84. PMID 16644289 DOI: 10.1016/j.ymthe.2006.03.005  1
2006 Seo BB, Nakamaru-Ogiso E, Flotte TR, Matsuno-Yagi A, Yagi T. In vivo complementation of complex I by the yeast Ndi1 enzyme. Possible application for treatment of Parkinson disease. The Journal of Biological Chemistry. 281: 14250-5. PMID 16543240 DOI: 10.1074/jbc.M600922200  1
2006 Lu Y, Choi YK, Campbell-Thompson M, Li C, Tang Q, Crawford JM, Flotte TR, Song S. Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector. The Journal of Gene Medicine. 8: 730-5. PMID 16518879 DOI: 10.1002/jgm.896  1
2006 Petrache I, Fijalkowska I, Zhen L, Medler TR, Brown E, Cruz P, Choe KH, Taraseviciene-Stewart L, Scerbavicius R, Shapiro L, Zhang B, Song S, Hicklin D, Voelkel NF, Flotte T, et al. A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. American Journal of Respiratory and Critical Care Medicine. 173: 1222-8. PMID 16514110 DOI: 10.1164/rccm.200512-1842OC  1
2006 Kaplan KA, Beierle EA, Faro A, Eskin TA, Flotte TR. Recurrent pneumonia in children: a case report and approach to diagnosis. Clinical Pediatrics. 45: 15-22. PMID 16429211 DOI: 10.1177/000992280604500103  1
2006 Müller C, Braag SA, Herlihy JD, Wasserfall CH, Chesrown SE, Nick HS, Atkinson MA, Flotte TR. Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 86: 130-40. PMID 16424881 DOI: 10.1038/labinvest.3700379  1
2006 Conlon TJ, Walter G, Owen R, Cossette T, Erger K, Gutierrez G, Goetzman E, Matern D, Vockley J, Flotte TR. Systemic correction of a fatty acid oxidation defect by intramuscular injection of a recombinant adeno-associated virus vector. Human Gene Therapy. 17: 71-80. PMID 16409126 DOI: 10.1089/hum.2006.17.71  1
2006 Flotte TR. New AAV serotypes may broaden the therapeutic pipeline to human gene therapy Molecular Therapy. 13: 1-2. PMID 16290078 DOI: 10.1016/j.ymthe.2005.11.004  1
2005 Flotte TR. Adeno-associated virus-based gene therapy for inherited disorders. Pediatric Research. 58: 1143-7. PMID 16306183 DOI: 10.1203/01.pdr.0000189226.03684.fe  1
2005 Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, Cruz PE, Roncal CA, Glushakova OY, Chiodo VA, Atkinson MA, Hauswirth WW, Flotte TR, Rodriguez-Iturbe B, Johnson RJ. IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. Journal of the American Society of Nephrology : Jasn. 16: 3651-60. PMID 16251240 DOI: 10.1681/ASN.2005030297  1
2005 Swiatecka-Urban A, Brown A, Moreau-Marquis S, Renuka J, Coutermarsh B, Barnaby R, Karlson KH, Flotte TR, Fukuda M, Langford GM, Stanton BA. The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells. The Journal of Biological Chemistry. 280: 36762-72. PMID 16131493 DOI: 10.1074/jbc.M508944200  1
2005 Conlon TJ, Cossette T, Erger K, Choi YK, Clarke T, Scott-Jorgensen M, Song S, Campbell-Thompson M, Crawford J, Flotte TR. Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 867-75. PMID 16085464 DOI: 10.1016/j.ymthe.2005.05.016  1
2005 Flotte TR, Schwiebert EM, Zeitlin PL, Carter BJ, Guggino WB. Correlation between DNA transfer and cystic fibrosis airway epithelial cell correction after recombinant adeno-associated virus serotype 2 gene therapy. Human Gene Therapy. 16: 921-8. PMID 16076250 DOI: 10.1089/hum.2005.16.921  1
2005 Loiler SA, Tang Q, Clarke T, Campbell-Thompson ML, Chiodo V, Hauswirth W, Cruz P, Perret-Gentil M, Atkinson MA, Ramiya VK, Flotte TR. Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 519-27. PMID 15979413 DOI: 10.1016/j.ymthe.2005.04.017  1
2005 Flotte TR. Recent developments in recombinant AAV-mediated gene therapy for lung diseases. Current Gene Therapy. 5: 361-6. PMID 15975013 DOI: 10.2174/1566523054064986  1
2005 Flotte TR. Adeno-associated virus-mediated gene transfer for lung diseases. Human Gene Therapy. 16: 643-8. PMID 15960596 DOI: 10.1089/hum.2005.16.643  1
2005 Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Cruz PE, Hauswirth WW, Madsen KM, Croker BP, Berns KI, Atkinson MA, Flotte TR, Tisher CC, et al. Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 102: 7251-6. PMID 15878989 DOI: 10.1073/pnas.0502407102  1
2005 Flotte TR, Berns KI. Adeno-associated virus: a ubiquitous commensal of mammals. Human Gene Therapy. 16: 401-7. PMID 15871671 DOI: 10.1089/hum.2005.16.401  1
2005 Virella-Lowell I, Zusman B, Foust K, Loiler S, Conlon T, Song S, Chesnut KA, Ferkol T, Flotte TR. Enhancing rAAV vector expression in the lung. The Journal of Gene Medicine. 7: 842-50. PMID 15838934 DOI: 10.1002/jgm.759  1
2005 Milligan ED, Sloane EM, Langer SJ, Cruz PE, Chacur M, Spataro L, Wieseler-Frank J, Hammack SE, Maier SF, Flotte TR, Forsayeth JR, Leinwand LA, Chavez R, Watkins LR. Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Molecular Pain. 1: 9. PMID 15813997 DOI: 10.1186/1744-8069-1-9  1
2005 Chen S, Kapturczak M, Loiler SA, Zolotukhin S, Glushakova OY, Madsen KM, Samulski RJ, Hauswirth WW, Campbell-Thompson M, Berns KI, Flotte TR, Atkinson MA, Tisher CC, Agarwal A. Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human Gene Therapy. 16: 235-47. PMID 15761263 DOI: 10.1089/hum.2005.16.235  1
2005 Mohiuddin I, Loiler S, Zolotukhin I, Byrne BJ, Flotte TR, Snyder RO. Herpesvirus-based infectious titering of recombinant adeno-associated viral vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 320-6. PMID 15668144 DOI: 10.1016/j.ymthe.2004.08.030  1
2004 Nyberg K, Carter BJ, Chen T, Dunbar C, Flotte TR, Rose S, Rosenblum D, Simek SL, Wilson C. Workshop on long-term follow-up of participants in human gene transfer research Molecular Therapy. 10: 976-980. PMID 16156012 DOI: 10.1016/j.ymthe.2004.10.011  1
2004 Song S, Witek RP, Lu Y, Choi YK, Zheng D, Jorgensen M, Li C, Flotte TR, Petersen BE. Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice. Hepatology (Baltimore, Md.). 40: 918-24. PMID 15382177 DOI: 10.1002/hep.20404  1
2004 Byoung BS, Nakamaru-Ogiso E, Cruz P, Flotte TR, Yagi T, Matsuno-Yagi A. Functional expression of the single subunit NADH dehydrogenase in mitochondria in vivo: A potential therapy for complex I deficiencies Human Gene Therapy. 15: 887-895. PMID 15353043 DOI: 10.1089/hum.2004.15.887  1
2004 Sirninger J, Muller C, Braag S, Tang Q, Yue H, Detrisac C, Ferkol T, Guggino WB, Flotte TR. Functional characterization of a recombinant adeno-associated virus 5-pseudotyped cystic fibrosis transmembrane conductance regulator vector Human Gene Therapy. 15: 832-841. PMID 15353038 DOI: 10.1089/1043034041839262  1
2004 Virella-Lowell I, Herlihy JD, Liu B, Lopez C, Cruz P, Muller C, Baker HV, Flotte TR. Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 562-73. PMID 15336656 DOI: 10.1016/j.ymthe.2004.06.215  1
2004 Conlon TJ, Flotte TR. Recombinant adeno-associated virus vectors for gene therapy. Expert Opinion On Biological Therapy. 4: 1093-101. PMID 15268676 DOI: 10.1517/14712598.4.7.1093  1
2004 Flotte TR. Immune responses to recombinant adeno-associated virus vectors: Putting preclinical findings into perspective Human Gene Therapy. 15: 716-717. PMID 15242531 DOI: 10.1089/1043034041361190  1
2004 Bray CL, Cahill KS, Oshier JT, Peden CS, Theriaque DW, Flotte TR, Stacpoole PW. Methylphenidate does not improve cognitive function in healthy sleep-deprived young adults. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 52: 192-201. PMID 15222409 DOI: 10.1136/jim-52-03-34  1
2004 Flotte TR. Gene therapy progress and prospects: Recombinant adeno-associated virus (rAAV) vectors Gene Therapy. 11: 805-810. PMID 15042119 DOI: 10.1038/sj.gt.3302233  1
2004 Flotte TR, Brantly ML, Spencer LT, Byrne BJ, Spencer CT, Baker DJ, Humphries M. Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults. Human Gene Therapy. 15: 93-128. PMID 14965381 DOI: 10.1089/10430340460732490  1
2004 Song S, Lu Y, Choi YK, Han Y, Tang Q, Zhao G, Berns KI, Flotte TR. DNA-dependent PK inhibits adeno-associated virus DNA integration. Proceedings of the National Academy of Sciences of the United States of America. 101: 2112-6. PMID 14766968 DOI: 10.1073/pnas.0307833100  1
2004 Zhang YC, Powers M, Wasserfall C, Brusko T, Song S, Flotte T, Snyder RO, Potter M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick HS, Agarwal A, Ellis TM, Atkinson MA. Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity. Gene Therapy. 11: 233-40. PMID 14737082 DOI: 10.1038/sj.gt.3302144  1
2004 Song S, Goudy K, Campbell-Thompson M, Wasserfall C, Scott-Jorgensen M, Wang J, Tang Q, Crawford JM, Ellis TM, Atkinson MA, Flotte TR. Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice Gene Therapy. 11: 181-186. PMID 14712302 DOI: 10.1038/sj.gt.3302156  1
2004 Loiler SA, Flotte TR. Alternative capsid strategies for targeting recombinant AAV gene therapy Gene Therapy and Regulation. 2: 139-148. DOI: 10.1163/156855803322664628  1
2003 Burkhardt BR, Loiler SA, Anderson JA, Kilberg MS, Crawford JM, Flotte TR, Goudy KS, Ellis TM, Atkinson M. Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells. Annals of the New York Academy of Sciences. 1005: 237-41. PMID 14679068 DOI: 10.1196/annals.1288.035  1
2003 Fischer AC, Beck SE, Smith CI, Laube BL, Askin FB, Guggino SE, Adams RJ, Flotte TR, Guggino WB. Successful transgene expression with serial doses of aerosolized rAAV2 vectors in rhesus macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 918-26. PMID 14664794 DOI: 10.1016/j.ymthe.2003.08.015  0.44
2003 Goudy KS, Burkhardt BR, Wasserfall C, Song S, Campbell-Thompson ML, Brusko T, Powers MA, Clare-Salzler MJ, Sobel ES, Ellis TM, Flotte TR, Atkinson MA. Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion. Journal of Immunology (Baltimore, Md. : 1950). 171: 2270-8. PMID 12928371 DOI: 10.4049/jimmunol.171.5.2270  1
2003 Loiler SA, Conlon TJ, Song S, Tang Q, Warrington KH, Agarwal A, Kapturczak M, Li C, Ricordi C, Atkinson MA, Muzyczka N, Flotte TR. Targeting recombinant adeno-associated virus vectors to enhance gene transfer to pancreatic islets and liver. Gene Therapy. 10: 1551-8. PMID 12907946 DOI: 10.1038/sj.gt.3302046  1
2003 Flotte TR, Zeitlin PL, Reynolds TC, Heald AE, Pedersen P, Beck S, Conrad CK, Brass-Ernst L, Humphries M, Sullivan K, Wetzel R, Taylor G, Carter BJ, Guggino WB. Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study. Human Gene Therapy. 14: 1079-88. PMID 12885347 DOI: 10.1089/104303403322124792  1
2003 Flotte TR. The signal and the trap: Targeted delivery and retention of proteins in the mitochondrion Molecular Therapy. 7: 715-716. PMID 12803173 DOI: 10.1016/S1525-0016(03)00155-2  1
2003 Stacpoole PW, Owen R, Flotte TR. The pyruvate dehydrogenase complex as a target for gene therapy Current Gene Therapy. 3: 239-245. PMID 12762482  1
2003 Chen S, Agarwal A, Glushakova OY, Jorgensen MS, Salgar SK, Poirier A, Flotte TR, Croker BP, Madsen KM, Atkinson MA, Hauswirth WW, Berns KI, Tisher CC. Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors. Journal of the American Society of Nephrology : Jasn. 14: 947-58. PMID 12660329 DOI: 10.1097/01.ASN.0000057858.45649.F7  1
2003 Zhang YC, Pileggi A, Agarwal A, Molano RD, Powers M, Brusko T, Wasserfall C, Goudy K, Zahr E, Poggioli R, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick H, Flotte T, et al. Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes. 52: 708-16. PMID 12606512 DOI: 10.2337/diabetes.52.3.708  1
2003 Flotte TR. Precision-guided genetic ordnance: New developments in receptor targeting of recombinant AAV Gene Therapy. 10: 2051. DOI: 10.1038/sj.gt.3302161  1
2002 Snyder RO, Flotte TR. Production of clinical-grade recombinant adeno-associated virus vectors Current Opinion in Biotechnology. 13: 418-423. PMID 12459331 DOI: 10.1016/S0958-1669(02)00369-5  1
2002 Zhang YC, Molano RD, Pileggi A, Powers M, Cross J, Wasserfall C, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Flotte T, Ellis TM, Ricordi C, Atkinson MA, Inverardi L. Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation. Transplantation. 74: 1184-6. PMID 12438968 DOI: 10.1097/00007890-200210270-00022  1
2002 Zolotukhin S, Potter M, Zolotukhin I, Sakai Y, Loiler S, Fraites TJ, Chiodo VA, Phillipsberg T, Muzyczka N, Hauswirth WW, Flotte TR, Byrne BJ, Snyder RO. Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. Methods (San Diego, Calif.). 28: 158-67. PMID 12413414 DOI: 10.1016/S1046-2023(02)00220-7  1
2002 Barbour KW, Wei F, Brannan C, Flotte TR, Baumann H, Berger FG. The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure. Genomics. 80: 515-22. PMID 12408969 DOI: 10.1016/S0888-7543(02)96864-3  1
2002 Beck SE, Laube BL, Barberena CI, Fischer AC, Adams RJ, Chesnut K, Flotte TR, Guggino WB. Deposition and expression of aerosolized rAAV vectors in the lungs of Rhesus macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 546-54. PMID 12387250 DOI: 10.1006/mthe.2002.0698  0.44
2002 Owen R, Mandel RJ, Ammini CV, Conlon TJ, Kerr DS, Stacpoole PW, Flotte TR. Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 394-9. PMID 12231176 DOI: 10.1006/mthe.2002.0683  1
2002 Seo BB, Nakamaru-Ogiso E, Flotte TR, Yagi T, Matsuno-Yagi A. A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition Molecular Therapy. 6: 336-341. PMID 12231169 DOI: 10.1006/mthe.2002.0674  1
2002 Song S, Scott-Jorgensen M, Wang J, Poirier A, Crawford J, Campbell-Thompson M, Flotte TR. Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspects. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 329-35. PMID 12231168 DOI: 10.1006/mthe.2002.0673  1
2002 Mah C, Byrne BJ, Flotte TR. Virus-based gene delivery systems Clinical Pharmacokinetics. 41: 901-911. PMID 12222993  1
2002 Wagner JA, Nepomuceno IB, Messner AH, Moran ML, Batson EP, Dimiceli S, Brown BW, Desch JK, Norbash AM, Conrad CK, Guggino WB, Flotte TR, Wine JJ, Carter BJ, Reynolds TC, et al. A phase II, double-blind, randomized, placebo-controlled clinical trial of tgAAVCF using maxillary sinus delivery in patients with cystic fibrosis with antrostomies. Human Gene Therapy. 13: 1349-59. PMID 12162817 DOI: 10.1089/104303402760128577  1
2002 Mah C, Fraites TJ, Zolotukhin I, Song S, Flotte TR, Dobson J, Batich C, Byrne BJ. Improved method of recombinant AAV2 delivery for systemic targeted gene therapy Molecular Therapy. 6: 106-112. PMID 12095310 DOI: 10.1006/mthe.2001.0636  1
2002 Flotte TR, Virella-Lowell I, Chesnut KA. Adeno-associated viral vectors for CF gene therapy Methods in Molecular Medicine. 70: 599-608. PMID 11917554  1
2002 Flotte TR. Recombinant adeno-associated virus gene therapy for cystic fibrosis and α1-antitrypsin deficiency Chest. 121: 98S-102S. PMID 11893723  1
2002 Potter M, Chesnut K, Muzyczka N, Flotte T, Zolotukhin S. Streamlined large-scale production of recombinant adeno-associated virus (rAAV) vectors. Methods in Enzymology. 346: 413-30. PMID 11883083 DOI: 10.1016/S0076-6879(02)46069-7  0.44
2002 Kapturczak M, Zolotukhin S, Cross J, Pileggi A, Molano RD, Jorgensen M, Byrne B, Flotte TR, Ellis T, Inverardi L, Ricordi C, Nick H, Atkinson M, Agarwal A. Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 154-60. PMID 11829522 DOI: 10.1006/mthe.2002.0522  1
2001 Kapturczak MH, Flotte T, Atkinson MA. Adeno-Associated Virus (AAV) as a vehicle for therapeutic gene delivery: Improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes Current Molecular Medicine. 1: 245-258. PMID 11899074  1
2001 De Grey A, Flotte TR, Owen IV R. Response to "approaches and limitations to gene therapy for mitochondrial diseases," Antioxid. Redox Signal. 2001;3:451-460 (multiple letters) Antioxidants and Redox Signaling. 3: 1153-1155. PMID 11813989  1
2001 Goudy K, Song S, Wasserfall C, Zhang YC, Kapturczak M, Muir A, Powers M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Ellis TM, Flotte TR, Atkinson MA. Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice Proceedings of the National Academy of Sciences of the United States of America. 98: 13913-13918. PMID 11717448 DOI: 10.1073/pnas.251532298  1
2001 Flotte TR. Recombinant adeno-associated virus vectors for cystic fibrosis gene therapy Current Opinion in Molecular Therapeutics. 3: 497-502. PMID 11699895  1
2001 Donsante A, Vogler C, Muzyczka N, Crawford JM, Barker J, Flotte T, Campbell-Thompson M, Daly T, Sands MS. Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. Gene Therapy. 8: 1343-6. PMID 11571571 DOI: 10.1038/sj.gt.3301541  1
2001 Song S, Embury J, Laipis PJ, Berns KI, Crawford JM, Flotte TR. Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Therapy. 8: 1299-306. PMID 11571566 DOI: 10.1038/sj.gt.3301422  1
2001 Flotte TR, Laube BL. Gene therapy in cystic fibrosis. Chest. 120: 124S-131S. PMID 11555567  1
2001 Owen IV R, Flotte TR. Approaches and limitations to gene therapy for mitochondrial diseases Antioxidants and Redox Signaling. 3: 451-460. PMID 11491656  1
2001 Song S, Laipis PJ, Berns KI, Flotte TR. Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 98: 4084-8. PMID 11274433 DOI: 10.1073/pnas.061014598  1
2001 Xu L, Daly T, Gao C, Flotte TR, Song S, Byrne BJ, Sands MS, Parker Ponder K. CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice. Human Gene Therapy. 12: 563-73. PMID 11268288 DOI: 10.1089/104303401300042500  1
2001 Flotte T, Agarwal A, Wang J, Song S, Fenjves ES, Inverardi L, Chesnut K, Afione S, Loiler S, Wasserfall C, Kapturczak M, Ellis T, Nick H, Atkinson M. Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors. Diabetes. 50: 515-20. PMID 11246870 DOI: 10.2337/diabetes.50.3.515  1
2001 Stacpoole PW, Fisher WR, Flotte TR, Geiser EA, Theriaque DW, Hutson AD. Teaching hypothesis-oriented thinking to medical students: the University of Florida's clinical investigation program. Academic Medicine : Journal of the Association of American Medical Colleges. 76: 287-92. PMID 11242585 DOI: 10.1097/00001888-200103000-00022  1
1993 Tomares SM, Flotte TR, Tunkel DE, Pao M, Loughlin GM. Real time laryngoscopy with olfactory challenge for diagnosis of psychogenic stridor. Pediatric Pulmonology. 16: 259-62. PMID 8265275  1
1991 Flotte TR, Loughlin GM. Benefits and complications of troleandomycin (TAO) in young children with steroid-dependent asthma. Pediatric Pulmonology. 10: 178-82. PMID 1852515  1
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