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Margaret W. Leigh, M.D. - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shapiro AJ, Dell SD, Gaston B, O'Connor M, Marozkina N, Manion M, Hazucha MJ, Leigh MW. Nasal Nitric Oxide Measurement in Primary Ciliary Dyskinesia: A Technical Paper on Standardized Testing Protocols. Annals of the American Thoracic Society. PMID 31770003 DOI: 10.1513/AnnalsATS.201904-347OT  0.32
2019 Shapiro AJ, Leigh MW, Omran H, Lavergne V, Knowles MR. Errors in Methodology Affect Diagnostic Accuracy of High-Speed Videomicroscopy Analysis in Primary Ciliary Dyskinesia. Chest. 156: 1032-1033. PMID 31699224 DOI: 10.1016/j.chest.2019.06.021  0.32
2019 Bustamante-Marin XM, Shapiro A, Sears PR, Charng WL, Conrad DF, Leigh MW, Knowles MR, Ostrowski LE, Zariwala MA. Identification of genetic variants in CFAP221 as a cause of primary ciliary dyskinesia. Journal of Human Genetics. PMID 31636325 DOI: 10.1038/s10038-019-0686-1  0.32
2019 Wallmeier J, Frank D, Shoemark A, Nöthe-Menchen T, Cindric S, Olbrich H, Loges NT, Aprea I, Dougherty GW, Pennekamp P, Kaiser T, Mitchison HM, Hogg C, Carr SB, Zariwala MA, ... ... Leigh MW, et al. De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry. American Journal of Human Genetics. PMID 31630787 DOI: 10.1016/j.ajhg.2019.09.022  0.44
2019 Leigh MW, Horani A, Kinghorn B, O'Connor MG, Zariwala MA, Knowles MR. Primary Ciliary Dyskinesia (PCD): A genetic disorder of motile cilia. Translational Science of Rare Diseases. 4: 51-75. PMID 31572664 DOI: 10.3233/TRD-190036  0.32
2019 Vece TJ, Sagel SD, Zariwala MA, Sullivan KM, Burns KA, Dutcher SK, Yusupov R, Leigh MW, Knowles MR. Cytoplasmic "ciliary inclusions" in isolation are not sufficient for the diagnosis of primary ciliary dyskinesia. Pediatric Pulmonology. PMID 31549486 DOI: 10.1002/ppul.24528  0.32
2019 Behan L, Leigh MW, Dell SD, Quittner AL, Hogg C, Lucas JS. Validation of pediatric health-related quality of life instruments for primary ciliary dyskinesia (QOL-PCD). Pediatric Pulmonology. PMID 31475479 DOI: 10.1002/ppul.24507  0.32
2019 Shapiro AJ, Ferkol TW, Manion M, Leigh MW, Davis SD, Knowles MR. High-Speed Videomicrosopy Analysis Presents Limitations in Diagnosis of Primary Ciliary Dyskinesia. American Journal of Respiratory and Critical Care Medicine. PMID 31433949 DOI: 10.1164/rccm.201907-1366LE  0.44
2019 Morimoto K, Hijikata M, Zariwala MA, Nykamp K, Inaba A, Guo TC, Yamada H, Truty R, Sasaki Y, Ohta K, Kudoh S, Leigh MW, Knowles MR, Keicho N. Recurring large deletion in DRC1 (CCDC164) identified as causing primary ciliary dyskinesia in two Asian patients. Molecular Genetics & Genomic Medicine. e838. PMID 31270959 DOI: 10.1002/mgg3.838  0.32
2018 Sanders CD, Leigh MW, Chao KC, Weck KE, King I, Wolf WE, Campbell DJ, Knowles MR, Zariwala MA, Shapiro AJ. The prevalence of the defining features of primary ciliary dyskinesia within a cri du chat syndrome cohort. Pediatric Pulmonology. PMID 30238669 DOI: 10.1002/ppul.24159  0.32
2018 Davis SD, Rosenfeld M, Lee HS, Ferkol TW, Sagel SD, Dell SD, Milla C, Pittman JE, Shapiro AJ, Sullivan KM, Nykamp KR, Krischer JP, Zariwala MA, Knowles MR, Leigh MW, et al. Primary Ciliary Dyskinesia: Longitudinal Study of Lung Disease by Ultrastructure Defect and Genotype. American Journal of Respiratory and Critical Care Medicine. PMID 30067075 DOI: 10.1164/rccm.201803-0548OC  0.44
2018 Shapiro AJ, Davis SD, Polineni D, Manion M, Rosenfeld M, Dell SD, Chilvers MA, Ferkol TW, Zariwala MA, Sagel SD, Josephson M, Morgan L, Yilmaz O, Olivier KN, Milla C, ... ... Leigh MW, et al. Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline. American Journal of Respiratory and Critical Care Medicine. 197: e24-e39. PMID 29905515 DOI: 10.1164/rccm.201805-0819ST  0.44
2017 Knowles MR, Leigh MW. Primary Ciliary Dyskinesia Diagnosis. Is Color Better Than Black and White? American Journal of Respiratory and Critical Care Medicine. 196: 9-10. PMID 28665204 DOI: 10.1164/rccm.201702-0426ED  0.32
2017 Pittman JE, Noah H, Calloway HE, Davis SD, Leigh MW, Drumm M, Sagel SD, Accurso FJ, Knowles MR, Sontag MK. Early childhood lung function is a stronger predictor of adolescent lung function in cystic fibrosis than early Pseudomonas aeruginosa infection. Plos One. 12: e0177215. PMID 28505188 DOI: 10.1371/journal.pone.0177215  0.44
2017 Leigh MW, Knowles MR. Assessment of Ciliary Beat Pattern: Variability in Healthy Control Subjects Has Implications for Use as Test for Primary Ciliary Dyskinesia. Chest. 151: 958-959. PMID 28483130 DOI: 10.1016/j.chest.2016.11.025  0.32
2017 Shapiro AJ, Josephson M, Rosenfeld M, Yilmaz O, Davis SD, Polineni D, Guadagno E, Leigh MW, Lavergne V. Accuracy of Nasal Nitric Oxide Measurement as a Diagnostic Test for Primary Ciliary Dyskinesia: A Systematic Review and Meta-Analysis. Annals of the American Thoracic Society. PMID 28481653 DOI: 10.1513/AnnalsATS.201701-062SR  0.44
2017 Behan L, Leigh MW, Dell SD, Dunn Galvin A, Quittner AL, Lucas JS. Validation of a health-related quality of life instrument for primary ciliary dyskinesia (QOL-PCD). Thorax. PMID 28246220 DOI: 10.1136/thoraxjnl-2016-209356  0.32
2016 Lewis WR, Malarkey EB, Tritschler D, Bower R, Pasek RC, Porath JD, Birket SE, Saunier S, Antignac C, Knowles MR, Leigh MW, Zariwala MA, Challa AK, Kesterson RA, Rowe SM, et al. Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease. Plos Genetics. 12: e1006220. PMID 27472056 DOI: 10.1371/journal.pgen.1006220  0.32
2016 Dell SD, Leigh MW, Lucas JS, Ferkol TW, Knowles MR, Alpern A, Behan L, Morris AM, Hogg C, DunnGalvin A, Quittner AL. Primary Ciliary Dyskinesia: First Health-related Quality of Life Measures for Pediatric Patients. Annals of the American Thoracic Society. PMID 27464304 DOI: 10.1513/AnnalsATS.201603-198OC  0.36
2016 Leigh MW, Ferkol TW, Davis SD, Lee HS, Rosenfeld M, Dell SD, Sagel SD, Milla C, Olivier KN, Sullivan KM, Zariwala MA, Pittman J, Shapiro AJ, Carson JL, Krischer J, et al. Clinical Features and Associated Likelihood of Primary Ciliary Dyskinesia in Children and Adolescents. Annals of the American Thoracic Society. PMID 27070726 DOI: 10.1513/AnnalsATS.201511-748OC  0.64
2015 Werner C, Lablans M, Ataian M, Raidt J, Wallmeier J, Große-Onnebrink J, Kuehni CE, Haarman EG, Leigh MW, Quittner AL, Lucas JS, Hogg C, Witt M, Priftis KN, Yiallouros P, et al. An international registry for primary ciliary dyskinesia. The European Respiratory Journal. PMID 26659107 DOI: 10.1183/13993003.00776-2015  0.92
2015 Shapiro AJ, Zariwala MA, Ferkol T, Davis SD, Sagel SD, Dell SD, Rosenfeld M, Olivier KN, Milla C, Daniel SJ, Kimple AJ, Manion M, Knowles MR, Leigh MW. Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review. Pediatric Pulmonology. PMID 26418604 DOI: 10.1002/ppul.23304  0.92
2015 Lucas JS, Behan L, Dunn Galvin A, Alpern A, Morris AM, Carroll MP, Knowles MR, Leigh MW, Quittner AL. A quality-of-life measure for adults with primary ciliary dyskinesia: QOL-PCD. The European Respiratory Journal. PMID 25976687 DOI: 10.1183/09031936.00216214  0.92
2015 Davis SD, Ferkol TW, Rosenfeld M, Lee HS, Dell SD, Sagel SD, Milla C, Zariwala MA, Pittman JE, Shapiro AJ, Carson JL, Krischer JP, Hazucha MJ, Cooper ML, Knowles MR, ... Leigh MW, et al. Clinical features of childhood primary ciliary dyskinesia by genotype and ultrastructural phenotype. American Journal of Respiratory and Critical Care Medicine. 191: 316-24. PMID 25493340 DOI: 10.1164/rccm.201409-1672OC  0.92
2015 Shapiro AJ, Tolleson-Rinehart S, Zariwala MA, Knowles MR, Leigh MW. The prevalence of clinical features associated with primary ciliary dyskinesia in a heterotaxy population: results of a web-based survey. Cardiology in the Young. 25: 752-9. PMID 24905662 DOI: 10.1017/S1047951114000912  0.92
2014 Lin J, Yin W, Smith MC, Song K, Leigh MW, Zariwala MA, Knowles MR, Ostrowski LE, Nicastro D. Cryo-electron tomography reveals ciliary defects underlying human RSPH1 primary ciliary dyskinesia. Nature Communications. 5: 5727. PMID 25473808 DOI: 10.1038/ncomms6727  0.92
2014 Lucas JS, Leigh MW. Diagnosis of primary ciliary dyskinesia: searching for a gold standard. The European Respiratory Journal. 44: 1418-22. PMID 25435529 DOI: 10.1183/09031936.00175614  0.92
2014 Shapiro AJ, Leigh MW. Response. Chest. 146: e167-8. PMID 25367486 DOI: 10.1378/chest.14-1282  0.92
2014 Byerley JS, Hernandez ML, Leigh MW, Antoon JW. Clinical approach to endogenous lipoid pneumonia. The Clinical Respiratory Journal. PMID 25123703 DOI: 10.1111/crj.12203  0.92
2014 Antoon JW, Hernandez ML, Roehrs PA, Noah TL, Leigh MW, Byerley JS. Endogenous lipoid pneumonia preceding diagnosis of pulmonary alveolar proteinosis. The Clinical Respiratory Journal. PMID 25103284 DOI: 10.1111/crj.12197  0.92
2014 Shapiro AJ, Weck KE, Chao KC, Rosenfeld M, Nygren AO, Knowles MR, Leigh MW, Zariwala MA. Cri du chat syndrome and primary ciliary dyskinesia: a common genetic cause on chromosome 5p. The Journal of Pediatrics. 165: 858-61. PMID 25066065 DOI: 10.1016/j.jpeds.2014.06.048  0.92
2014 Henderson AG, Ehre C, Button B, Abdullah LH, Cai LH, Leigh MW, DeMaria GC, Matsui H, Donaldson SH, Davis CW, Sheehan JK, Boucher RC, Kesimer M. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. The Journal of Clinical Investigation. 124: 3047-60. PMID 24892808 DOI: 10.1172/JCI73469  0.92
2014 Shapiro AJ, Davis SD, Ferkol T, Dell SD, Rosenfeld M, Olivier KN, Sagel SD, Milla C, Zariwala MA, Wolf W, Carson JL, Hazucha MJ, Burns K, Robinson B, Knowles MR, ... Leigh MW, et al. Laterality defects other than situs inversus totalis in primary ciliary dyskinesia: insights into situs ambiguus and heterotaxy. Chest. 146: 1176-86. PMID 24577564 DOI: 10.1378/chest.13-1704  0.92
2014 Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, et al. Mutations in RSPH1 cause primary ciliary dyskinesia with a unique clinical and ciliary phenotype. American Journal of Respiratory and Critical Care Medicine. 189: 707-17. PMID 24568568 DOI: 10.1164/rccm.201311-2047OC  0.92
2014 Funkhouser WK, Niethammer M, Carson JL, Burns KA, Knowles MR, Leigh MW, Zariwala MA, Funkhouser WK. A new tool improves diagnostic test performance for transmission em evaluation of axonemal dynein arms. Ultrastructural Pathology. 38: 248-55. PMID 23957500 DOI: 10.3109/01913123.2013.815081  0.92
2013 Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, ... ... Leigh MW, et al. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. American Journal of Human Genetics. 93: 672-86. PMID 24094744 DOI: 10.1016/j.ajhg.2013.08.015  0.92
2013 Knowles MR, Ostrowski LE, Loges NT, Hurd T, Leigh MW, Huang L, Wolf WE, Carson JL, Hazucha MJ, Yin W, Davis SD, Dell SD, Ferkol TW, Sagel SD, Olivier KN, et al. Mutations in SPAG1 cause primary ciliary dyskinesia associated with defective outer and inner dynein arms. American Journal of Human Genetics. 93: 711-20. PMID 24055112 DOI: 10.1016/j.ajhg.2013.07.025  0.92
2013 Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, et al. Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia. Annals of the American Thoracic Society. 10: 574-81. PMID 24024753 DOI: 10.1513/AnnalsATS.201305-110OC  0.92
2013 Zariwala MA, Gee HY, Kurkowiak M, Al-Mutairi DA, Leigh MW, Hurd TW, Hjeij R, Dell SD, Chaki M, Dougherty GW, Adan M, Spear PC, Esteve-Rudd J, Loges NT, Rosenfeld M, et al. ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6. American Journal of Human Genetics. 93: 336-45. PMID 23891469 DOI: 10.1016/j.ajhg.2013.06.007  0.92
2013 Tarkar A, Loges NT, Slagle CE, Francis R, Dougherty GW, Tamayo JV, Shook B, Cantino M, Schwartz D, Jahnke C, Olbrich H, Werner C, Raidt J, Pennekamp P, Abouhamed M, ... ... Leigh MW, et al. DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nature Genetics. 45: 995-1003. PMID 23872636 DOI: 10.1038/ng.2707  0.92
2013 Hjeij R, Lindstrand A, Francis R, Zariwala MA, Liu X, Li Y, Damerla R, Dougherty GW, Abouhamed M, Olbrich H, Loges NT, Pennekamp P, Davis EE, Carvalho CM, Pehlivan D, ... ... Leigh MW, et al. ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. American Journal of Human Genetics. 93: 357-67. PMID 23849778 DOI: 10.1016/j.ajhg.2013.06.009  0.92
2013 Daniels ML, Leigh MW, Davis SD, Armstrong MC, Carson JL, Hazucha M, Dell SD, Eriksson M, Collins FS, Knowles MR, Zariwala MA. Founder mutation in RSPH4A identified in patients of Hispanic descent with primary ciliary dyskinesia. Human Mutation. 34: 1352-6. PMID 23798057 DOI: 10.1002/humu.22371  0.92
2013 Knowles MR, Daniels LA, Davis SD, Zariwala MA, Leigh MW. Primary ciliary dyskinesia. Recent advances in diagnostics, genetics, and characterization of clinical disease. American Journal of Respiratory and Critical Care Medicine. 188: 913-22. PMID 23796196 DOI: 10.1164/rccm.201301-0059CI  0.92
2013 Ferkol TW, Puffenberger EG, Lie H, Helms C, Strauss KA, Bowcock A, Carson JL, Hazucha M, Morton DH, Patel AC, Leigh MW, Knowles MR, Zariwala MA. Primary ciliary dyskinesia-causing mutations in Amish and Mennonite communities. The Journal of Pediatrics. 163: 383-7. PMID 23477994 DOI: 10.1016/j.jpeds.2013.01.061  0.92
2013 Knowles MR, Leigh MW, Ostrowski LE, Huang L, Carson JL, Hazucha MJ, Yin W, Berg JS, Davis SD, Dell SD, Ferkol TW, Rosenfeld M, Sagel SD, Milla CE, Olivier KN, et al. Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia. American Journal of Human Genetics. 92: 99-106. PMID 23261302 DOI: 10.1016/j.ajhg.2012.11.003  0.92
2013 Shapiro AJ, Esther CR, Leigh MW, Dellon EP. Vaccine induced Hepatitis A and B protection in children at risk for cystic fibrosis associated liver disease. Vaccine. 31: 906-11. PMID 23261047 DOI: 10.1016/j.vaccine.2012.12.004  0.92
2013 Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A, Forouhan M, Wilson R, Taylor-Cox T, Dewar A, Jackson C, Goggin P, Loges NT, Olbrich H, Jaspers M, Jorissen M, ... Leigh MW, et al. Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms. Human Mutation. 34: 462-72. PMID 23255504 DOI: 10.1002/humu.22261  0.92
2012 Horani A, Druley TE, Zariwala MA, Patel AC, Levinson BT, Van Arendonk LG, Thornton KC, Giacalone JC, Albee AJ, Wilson KS, Turner EH, Nickerson DA, Shendure J, Bayly PV, Leigh MW, et al. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. American Journal of Human Genetics. 91: 685-93. PMID 23040496 DOI: 10.1016/j.ajhg.2012.08.022  0.92
2012 Knowles MR, Leigh MW, Zariwala MA. Cutting edge genetic studies in primary ciliary dyskinesia. Thorax. 67: 464; author reply 46. PMID 22328589 DOI: 10.1136/thoraxjnl-2012-201609  0.92
2012 Knowles MR, Leigh MW, Carson JL, Davis SD, Dell SD, Ferkol TW, Olivier KN, Sagel SD, Rosenfeld M, Burns KA, Minnix SL, Armstrong MC, Lori A, Hazucha MJ, Loges NT, et al. Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure. Thorax. 67: 433-41. PMID 22184204 DOI: 10.1136/thoraxjnl-2011-200301  0.92
2012 Ferkol TW, Leigh MW. Ciliopathies: the central role of cilia in a spectrum of pediatric disorders. The Journal of Pediatrics. 160: 366-71. PMID 22177992 DOI: 10.1016/j.jpeds.2011.11.024  0.92
2011 Leigh MW, O'Callaghan C, Knowles MR. The challenges of diagnosing primary ciliary dyskinesia. Proceedings of the American Thoracic Society. 8: 434-7. PMID 21926395 DOI: 10.1513/pats.201103-028SD  0.92
2011 Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. American Journal of Respiratory and Critical Care Medicine. 184: 602-15. PMID 21885636 DOI: 10.1164/rccm.9120-11ST  0.92
2011 Olin JT, Burns K, Carson JL, Metjian H, Atkinson JJ, Davis SD, Dell SD, Ferkol TW, Milla CE, Olivier KN, Rosenfeld M, Baker B, Leigh MW, Knowles MR, Sagel SD, et al. Diagnostic yield of nasal scrape biopsies in primary ciliary dyskinesia: a multicenter experience. Pediatric Pulmonology. 46: 483-8. PMID 21284095 DOI: 10.1002/ppul.21402  0.92
2011 Berg JS, Evans JP, Leigh MW, Omran H, Bizon C, Mane K, Knowles MR, Weck KE, Zariwala MA. Next generation massively parallel sequencing of targeted exomes to identify genetic mutations in primary ciliary dyskinesia: implications for application to clinical testing. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 13: 218-29. PMID 21270641 DOI: 10.1097/GIM.0b013e318203cff2  0.92
2011 Pittman JE, Calloway EH, Kiser M, Yeatts J, Davis SD, Drumm ML, Schechter MS, Leigh MW, Emond M, Van Rie A, Knowles MR. Age of Pseudomonas aeruginosa acquisition and subsequent severity of cystic fibrosis lung disease. Pediatric Pulmonology. 46: 497-504. PMID 21194167 DOI: 10.1002/ppul.21397  0.92
2010 Lie H, Zariwala MA, Helms C, Bowcock AM, Carson JL, Brown DE, Hazucha MJ, Forsen J, Molter D, Knowles MR, Leigh MW, Ferkol TW. Primary ciliary dyskinesia in Amish communities. The Journal of Pediatrics. 156: 1023-5. PMID 20350728 DOI: 10.1016/j.jpeds.2010.01.054  0.92
2010 Noah TL, Ivins SS, Abode KA, Stewart PW, Michelson PH, Harris WT, Henry MM, Leigh MW. Inhaled versus systemic antibiotics and airway inflammation in children with cystic fibrosis and Pseudomonas. Pediatric Pulmonology. 45: 281-90. PMID 20146365 DOI: 10.1002/ppul.21176  0.92
2009 Loges NT, Olbrich H, Becker-Heck A, Häffner K, Heer A, Reinhard C, Schmidts M, Kispert A, Zariwala MA, Leigh MW, Knowles MR, Zentgraf H, Seithe H, Nürnberg G, Nürnberg P, et al. Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects. American Journal of Human Genetics. 85: 883-9. PMID 19944400 DOI: 10.1016/j.ajhg.2009.10.018  0.92
2009 Leigh MW, Pittman JE, Carson JL, Ferkol TW, Dell SD, Davis SD, Knowles MR, Zariwala MA. Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 11: 473-87. PMID 19606528 DOI: 10.1097/GIM.0b013e3181a53562  0.92
2009 Peterson-Carmichael SL, Harris WT, Goel R, Noah TL, Johnson R, Leigh MW, Davis SD. Association of lower airway inflammation with physiologic findings in young children with cystic fibrosis. Pediatric Pulmonology. 44: 503-11. PMID 19382221 DOI: 10.1002/ppul.21044  0.92
2009 Leigh MW, Zariwala MA, Knowles MR. Primary ciliary dyskinesia: improving the diagnostic approach. Current Opinion in Pediatrics. 21: 320-5. PMID 19300264 DOI: 10.1097/MOP.0b013e328329cddb  0.92
2008 Brown DE, Pittman JE, Leigh MW, Fordham L, Davis SD. Early lung disease in young children with primary ciliary dyskinesia. Pediatric Pulmonology. 43: 514-6. PMID 18383332 DOI: 10.1002/ppul.20792  0.92
2008 Esther CR, Leigh MW. Genetics and Disease Mechanisms Pediatric Respiratory Medicine. 859-870. DOI: 10.1016/B978-032304048-8.50065-7  0.92
2007 Kennedy MP, Omran H, Leigh MW, Dell S, Morgan L, Molina PL, Robinson BV, Minnix SL, Olbrich H, Severin T, Ahrens P, Lange L, Morillas HN, Noone PG, Zariwala MA, et al. Congenital heart disease and other heterotaxic defects in a large cohort of patients with primary ciliary dyskinesia. Circulation. 115: 2814-21. PMID 17515466 DOI: 10.1161/CIRCULATIONAHA.106.649038  0.92
2007 Dellon EP, Leigh MW, Yankaskas JR, Noah TL. Effects of lung transplantation on inpatient end of life care in cystic fibrosis. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 6: 396-402. PMID 17481967 DOI: 10.1016/j.jcf.2007.03.005  0.92
2007 Kennedy MP, Noone PG, Leigh MW, Zariwala MA, Minnix SL, Knowles MR, Molina PL. High-resolution CT of patients with primary ciliary dyskinesia. Ajr. American Journal of Roentgenology. 188: 1232-8. PMID 17449765 DOI: 10.2214/AJR.06.0965  0.92
2007 Davis SD, Fordham LA, Brody AS, Noah TL, Retsch-Bogart GZ, Qaqish BF, Yankaskas BC, Johnson RC, Leigh MW. Computed tomography reflects lower airway inflammation and tracks changes in early cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 175: 943-50. PMID 17303797 DOI: 10.1164/rccm.200603-343OC  0.92
2006 Zariwala MA, Leigh MW, Ceppa F, Kennedy MP, Noone PG, Carson JL, Hazucha MJ, Lori A, Horvath J, Olbrich H, Loges NT, Bridoux AM, Pennarun G, Duriez B, Escudier E, et al. Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation. American Journal of Respiratory and Critical Care Medicine. 174: 858-66. PMID 16858015 DOI: 10.1164/rccm.200603-370OC  0.92
2006 Saito J, Harris WT, Gelfond J, Noah TL, Leigh MW, Johnson R, Davis SD. Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough. Pediatric Pulmonology. 41: 709-19. PMID 16779841 DOI: 10.1002/ppul.20387  0.92
2006 Muhlebach MS, Miller MB, Moore C, Wedd JP, Drake AF, Leigh MW. Are lower airway or throat cultures predictive of sinus bacteriology in cystic fibrosis? Pediatric Pulmonology. 41: 445-51. PMID 16547960 DOI: 10.1002/ppul.20396  0.92
2006 Leigh MW. Influenza Kendig's Disorders of the Respiratory Tract in Children. 485-490. DOI: 10.1016/B978-0-7216-3695-5.50035-3  0.92
2005 Esther CR, Henry MM, Molina PL, Leigh MW. Nontuberculous mycobacterial infection in young children with cystic fibrosis. Pediatric Pulmonology. 40: 39-44. PMID 15858802 DOI: 10.1002/ppul.20222  0.92
2004 Leigh MW. Diagnosis of CF despite normal or borderline sweat chloride. Paediatric Respiratory Reviews. 5: S357-9. PMID 14980295 DOI: 10.1016/S1526-0542(04)90062-0  0.92
2004 Noone PG, Leigh MW, Sannuti A, Minnix SL, Carson JL, Hazucha M, Zariwala MA, Knowles MR. Primary ciliary dyskinesia: diagnostic and phenotypic features. American Journal of Respiratory and Critical Care Medicine. 169: 459-67. PMID 14656747 DOI: 10.1164/rccm.200303-365OC  0.92
2004 Zariwala M, O'Neal WK, Noone PG, Leigh MW, Knowles MR, Ostrowski LE. Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia. American Journal of Respiratory Cell and Molecular Biology. 30: 428-34. PMID 14630615 DOI: 10.1165/rcmb.2003-0338RC  0.92
2003 Leigh MW. Primary ciliary dyskinesia. Seminars in Respiratory and Critical Care Medicine. 24: 653-62. PMID 16088581 DOI: 10.1055/s-2004-815661  0.92
2003 Noah TL, Murphy PC, Alink JJ, Leigh MW, Hull WM, Stahlman MT, Whitsett JA. Bronchoalveolar lavage fluid surfactant protein-A and surfactant protein-D are inversely related to inflammation in early cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 168: 685-91. PMID 12829455 DOI: 10.1164/rccm.200301-005OC  0.92
2002 Noone PG, Zariwala M, Sannuti A, Minnix S, Leigh MW, Carson J, Knowles MR. Mutations in DNAI1 (IC78) cause primary ciliary dyskinesia. Chest. 121: 97S. PMID 11893720  0.92
2001 Zariwala M, Noone PG, Sannuti A, Minnix S, Zhou Z, Leigh MW, Hazucha M, Carson JL, Knowles MR. Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia. American Journal of Respiratory Cell and Molecular Biology. 25: 577-83. PMID 11713099 DOI: 10.1165/ajrcmb.25.5.4619  0.92
2000 Reed W, Carson JL, Moats-Staats BM, Lucier T, Hu P, Brighton L, Gambling TM, Huang CH, Leigh MW, Collier AM. Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis. American Journal of Respiratory Cell and Molecular Biology. 23: 734-41. PMID 11104725 DOI: 10.1165/ajrcmb.23.6.4045  0.92
2000 Noone PG, Hohneker KW, Zhou Z, Johnson LG, Foy C, Gipson C, Jones K, Noah TL, Leigh MW, Schwartzbach C, Efthimiou J, Pearlman R, Boucher RC, Knowles MR. Safety and biological efficacy of a lipid-CFTR complex for gene transfer in the nasal epithelium of adult patients with cystic fibrosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 105-14. PMID 10933918 DOI: 10.1006/mthe.1999.0009  0.92
2000 Britto MT, Garrett JM, Konrad TR, Majure JM, Leigh MW. Role of leukotrienes in asthma pathophysiology Pediatric Pulmonology. 30: 166-176. PMID 10922142 DOI: 10.1002/1099-0496(200008)30:2<166::AID-PPUL15>3.0.CO;2-L  0.92
1999 Muhlebach MS, Stewart PW, Leigh MW, Noah TL. Quantitation of inflammatory responses to bacteria in young cystic fibrosis and control patients. American Journal of Respiratory and Critical Care Medicine. 160: 186-91. PMID 10390398 DOI: 10.1164/ajrccm.160.1.9808096  0.92
1999 Britto MT, Garrett JM, Dugliss MA, Johnson CA, Majure JM, Leigh MW. Preventive services received by adolescents with cystic fibrosis and sickle cell disease. Archives of Pediatrics & Adolescent Medicine. 153: 27-32. PMID 9894996  0.92
1998 Britto MT, Garrett JM, Dugliss MA, Daeschner CW, Johnson CA, Leigh MW, Majure JM, Schultz WH, Konrad TR. Risky behavior in teens with cystic fibrosis or sickle cell disease: a multicenter study. Pediatrics. 101: 250-6. PMID 9445499 DOI: 10.1542/peds.101.2.250  0.92
1998 Friedman KJ, Leigh MW, Czarnecki P, Feldman GL. Cystic fibrosis transmembrane-conductance regulator mutations among African Americans. American Journal of Human Genetics. 62: 195-6. PMID 9443874 DOI: 10.1086/301681  0.92
1997 Piedimonte G, Wolford ET, Fordham LA, Leigh MW, Wood RE. Mediastinal lymphadenopathy caused by Mycobacterium avium-intracellulare complex in a child with normal immunity: successful treatment with anti-mycobacterial drugs and laser bronchoscopy. Pediatric Pulmonology. 24: 287-91. PMID 9368263 DOI: 10.1002/(SICI)1099-0496(199710)24:4<287::AID-PPUL8>3.0.CO;2-H  0.92
1997 Noah TL, Black HR, Cheng PW, Wood RE, Leigh MW. Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis. The Journal of Infectious Diseases. 175: 638-47. PMID 9041336  0.92
1996 Noah TL, Wortman IA, Hu PC, Leigh MW, Boucher RC. Cytokine production by cultured human bronchial epithelial cells infected with a replication-deficient adenoviral gene transfer vector or wild-type adenovirus type 5. American Journal of Respiratory Cell and Molecular Biology. 14: 417-24. PMID 8624246 DOI: 10.1165/ajrcmb.14.5.8624246  0.92
1995 Leigh MW, Connor RJ, Kelm S, Baum LG, Paulson JC. Receptor specificity of influenza virus influences severity of illness in ferrets. Vaccine. 13: 1468-73. PMID 8578828 DOI: 10.1016/0264-410X(95)00004-K  0.92
1995 Leigh MW, Kylander JE, Yankaskas JR, Boucher RC. Cell proliferation in bronchial epithelium and submucosal glands of cystic fibrosis patients. American Journal of Respiratory Cell and Molecular Biology. 12: 605-12. PMID 7766425 DOI: 10.1165/ajrcmb.12.6.7766425  0.92
1995 Teramoto S, Johnson LG, Huang W, Leigh MW, Boucher RC. Effect of adenoviral vector infection on cell proliferation in cultured primary human airway epithelial cells. Human Gene Therapy. 6: 1045-53. PMID 7578417 DOI: 10.1089/hum.1995.6.8-1045  0.92
1995 Knowles MR, Hohneker KW, Zhou Z, Olsen JC, Noah TL, Hu PC, Leigh MW, Engelhardt JF, Edwards LJ, Jones KR. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. The New England Journal of Medicine. 333: 823-31. PMID 7544439 DOI: 10.1056/NEJM199509283331302  0.92
1993 Schwab UE, Wold AE, Carson JL, Leigh MW, Cheng PW, Gilligan PH, Boat TF. Increased adherence of Staphylococcus aureus from cystic fibrosis lungs to airway epithelial cells. The American Review of Respiratory Disease. 148: 365-9. PMID 8342900 DOI: 10.1164/ajrccm/148.2.365  0.92
1992 Leigh MW, Carson JL, Gambling TM, Boat TF. Loss of cilia and altered phenotypic expression of ciliated cells after acute sulfur dioxide exposure. Chest. 101: 16S. PMID 1541186  0.92
1992 Voter KZ, Leigh MW, Boat TF, Carson JL, Wood RE. Development of mucociliary transport in the postnatal ferret trachea. Journal of Applied Physiology (Bethesda, Md. : 1985). 73: 1500-3. PMID 1447097  0.92
1992 Leigh MW. Lower respiratory tract infections in children Current Opinion in Pediatrics. 4: 417-425.  0.92
1991 Piazza FM, Carson JL, Hu SC, Leigh MW. Attachment of influenza A virus to ferret tracheal epithelium at different maturational stages. American Journal of Respiratory Cell and Molecular Biology. 4: 82-7. PMID 1986780 DOI: 10.1165/ajrcmb/4.1.82  0.92
1991 Perez CR, Leigh MW. Mycoplasma pneumoniae as the causative agent for pneumonia in the immunocompromised host. Chest. 100: 860-1. PMID 1889288  0.92
1991 Leigh MW, Carson JL, Denny FW. Pathogenesis of respiratory infections due to influenza virus: implications for developing countries. Reviews of Infectious Diseases. 13: S501-8. PMID 1862279  0.92
1990 Wood RE, Leigh MW, Retsch-Bogart G. Diagnosis of pneumonia in immunocompromised patients. The Journal of Pediatrics. 116: 836-7. PMID 2329436 DOI: 10.1016/S0022-3476(05)82687-3  0.92
1989 Leigh MW, Cheng PW, Boat TF. Developmental changes of ferret tracheal mucin composition and biosynthesis. Biochemistry. 28: 9440-6. PMID 2611242 DOI: 10.1021/bi00450a029  0.92
1989 Leigh MW, Cheng PW, Boat TF. Increased secretion of glycoconjugates by influenza-infected ferret tracheas Chest. 95: 221S-222S.  0.92
1988 Carson JL, Collier AM, Gambling TM, Leigh MW, Boucher RC, Hu SC, Boat TF. Development, organization, and function of tight junctional complexes in the tracheal epithelium of infant ferrets. The American Review of Respiratory Disease. 138: 666-74. PMID 3202419 DOI: 10.1164/ajrccm/138.3.666  0.92
1987 Wood RE, Leigh MW. What is a "pulmonary exacerbation" in cystic fibrosis? The Journal of Pediatrics. 111: 841-2. PMID 3681548 DOI: 10.1016/S0022-3476(87)80198-1  0.92
1987 Curtis LN, Carson JL, Collier AM, Gambling TM, Hu SS, Leigh MW, Boat TF. Features of developing ferret tracheal epithelium: ultrastructural observations of in vivo and in vitro differentiation of ciliated cells. Experimental Lung Research. 13: 223-40. PMID 3665853 DOI: 10.3109/01902148709064320  0.92
1987 Leigh MW, Clyde WA. Chlamydial and mycoplasmal pneumonias. Seminars in Respiratory Infections. 2: 152-8. PMID 3120269  0.92
1986 Leigh MW, Cheng PW, Carson JL, Boat TF. Developmental changes in glycoconjugate secretion by ferret tracheas. The American Review of Respiratory Disease. 134: 784-90. PMID 3532888  0.92
1986 Leigh MW, Gambling TM, Carson JL, Collier AM, Wood RE, Boat TF. Postnatal development of tracheal surface epithelium and submucosal glands in the ferret. Experimental Lung Research. 10: 153-69. PMID 2420581 DOI: 10.3109/01902148609061490  0.92
1985 McDonnell WF, Chapman RS, Leigh MW, Strope GL, Collier AM. Respiratory responses of vigorously exercising children to 0.12 ppm ozone exposure. The American Review of Respiratory Disease. 132: 875-9. PMID 4051323  0.92
1985 Leigh MW, Henshaw NG, Wood RE. Diagnosis of Pneumocystis carinii pneumonia in pediatric patients using bronchoscopic bronchoalveolar lavage. Pediatric Infectious Disease. 4: 408-10. PMID 3875082  0.92
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