1996 — 1999 |
Beck, Thomas Harlow, Henry Mccormick, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Muscle Morphology and Physiology of Overwintering Black Bears
9514105 Harlow Disuse atrophy of skeletal muscle is a problem faced by inactive animals whether it be hospital patients, astronauts in a space vehicle or constrained animals during winter dormancy. Muscle disuse atrophy results from a decrease in muscle mass due to a reduction in the number of fibers, a decrease in the size of the cells or a combination of the two. Since the hibernating black bears show little protein loss during winter inactivity and are thus an excellent model for investigating how some animals avoid muscle disuse atrophy, the PI plans to study the mechanism involved in the intracellular and extracellular protein changes. The PI will also determine if lactation laces a greater demand on muscle protein degradation. These studies will also determine how much fat (for energy) and protein (for water) are required by overwintering bears and what the lactation demands are on fat and muscle tissues in order to properly evaluate the bear as a muscle conserver during periods of inactivity.
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1 |
2003 |
Mccormick, Richard J |
R15Activity Code Description: Supports small-scale research projects at educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation’s research scientists but that have not been major recipients of NIH support. The goals of the program are to (1) support meritorious research, (2) expose students to research, and (3) strengthen the research environment of the institution. Awards provide limited Direct Costs, plus applicable F&A costs, for periods not to exceed 36 months. This activity code uses multi-year funding authority; however, OER approval is NOT needed prior to an IC using this activity code. |
Genome-Wide Cardiac Transciption Patterns Post-Mi
DESCRIPTION (provided by applicant): Substantial alterations in gene expression must occur to produce the profound changes observed in surviving myocardium following ischemia leading to myocardial infarction (MI). Currently a genome-wide expression database for transcriptional changes in response to MI is not available. The production of such a database will aid in identification of the roles and potential interactions of many genes involved in the earliest signaling pathways post-MI. Thus the first aim is to establish an expression database for normal mouse left ventricle (LV) and from LV at selected time-points, starting from 15 min post-coronary artery ligation (ischemia) to 48 hrs post-MI. These time-points will thus encompass the earliest ischemic (minutes), inflammatory (minutes/hours/days), degradative and repair (hours/days) responses in the LV following coronary artery occlusion. Based on our preliminary findings for the first two proposed time-points, differences in the earliest patterns of gene expression within the LV are related to both duration of occlusion and proximity to the ischemic/infarcted zone. The second aim is to build testable model(s) of the signaling pathways in LV that are triggered by ischemia leading to infarction. In order to deeply mine the data, genes of known biochemical function will be analyzed separately from estimated sequence tags (ESTs). For known genes, both the primary literature and the implementation of computer-based natural language methods will be instrumental in their functional assignment to a particular biochemical or signaling pathway. For ESTs, a combination of standard clustering algorithms and domain/motif searches of protein databases will be used to generate patterns, classifications, and possible functional annotations. The long-range goal of this research is investigation of changes in the cardiac proteome in response to MI using knock-out and other transgenic mice to test specific hypotheses generated by analysis of the gene expression database. This grant will provide a research experience for two undergraduate students spanning two years, which will take advantage of the existing NSF and DOE EPSCoR infrastructure for undergraduate training at the University of Wyoming.
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0.958 |
2010 — 2014 |
Nichols, Andrew Mccormick, Richard Wait, Isaac Wahjudi, Paulus |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Collaborative Research: Implementing and Assessing Strategies For Environments For Fostering Effective Critical Thinking (Effects) Development and Implementation @ Marshall University Research Corporation
The project is a collaboration between the University of South Carolina and Marshall University. It is establishing strategies to aid faculty in the design and implementation of special instructional modules (EFFECTs) designed to foster critical thinking. This proposal leverages the success of a Phase I CCLI project that defined the pedagogical structure for the EFFECTS, generated six EFFECTs, and developed an assessment methodology. Each module contains three elements: 1) a decision worksheet that guides an initial design for the first class period, 2) active learning modules and journal questions during the next n class periods, and 3) material to guides a group discussion to produce a final design during the last class period. Using these modules in several classes under the earlier grant led to gains in the students' core knowledge and critical thinking skills. Developing a systematic approach that enables other faculty to use EFFECTs is a key aspect for disseminating the approach widely through the engineering education community. To achieve this, the investigators are working to develop instructional material to teach the EFFECTs to faculty, to expand current assessment tools, to develop a community of practice to support the design and implementation of EFFECTs, and to assess the strategies developed to design and implement EFFECTs. Dissemination is being accomplished through web postings, including links with the NSDL, through conference presentation and journal publications, and through faculty workshops. A comprehensive evaluation effort, under the direction of an independent expert, includes the monitoring of student learning outcomes using instruments for measuring scientific reasoning skills, critical thinking skills, and content knowledge. Broader impacts include the dissemination of the material and the evaluation results, faculty workshops, and outreach through existing K-12 programs.
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0.948 |