Area:
Human Development, Cell Biology
We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Catherine L. May is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2002 — 2004 |
May, Catherine Lee |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
The Role of Neurogenin 3 in Pancreas Development @ University of Pennsylvania
DESCRIPTION: Ngn3 (neurogenin 3) is a bHLH transcription factor expressed in the pancreatic endocrine precursor cells. Ngn3 mRNA is found in the developing pancreas between day 9 and 18.5 of gestation. Expression of ngn3 is extinguished in differentiated islet alpha and beta cells, as it never co-localizes with glucagon or insulin. Homozygous null mice for Ngn3 develop severe diabetes and die 2-3 days after birth. No islet of Langerhans are present in the pancreas in these mutant animals. Thus, Ngn3 is absolutely essential for the pancreatic endocrine cell development and it is also the earliest marker for endocrine precursor cells. The following specific aims will be pursued through this proposal: 1) To generate a Ngn3-GFP mouse by homologous recombination to be used in lineage tracing study and for the purification and culture of endocrine stem cells. 2) To identify early and late target genes of Ngn3 using microarray technology.
|
1 |
2007 — 2012 |
May, Catherine Lee |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. R56Activity Code Description: To provide limited interim research support based on the merit of a pending R01 application while applicant gathers additional data to revise a new or competing renewal application. This grant will underwrite highly meritorious applications that if given the opportunity to revise their application could meet IC recommended standards and would be missed opportunities if not funded. Interim funded ends when the applicant succeeds in obtaining an R01 or other competing award built on the R56 grant. These awards are not renewable. |
Transcriptional Regulation of Pancreas Development and Function @ Childrens Hospital of Philadelphia
Diabetes mellitus is a metabolic disorder that currently affects over 180 million people worldwide. Common to all forms of diabetes is the gradual loss of functional insulin-producing p-cells in the endocrine pancreas. A hierarchy of transcription factors has been demonstrated to control the development and function of the endocrine pancreas. Islet-1 (lsl-1), is a homeo-domain containing transcription factor that is expressed in embryonic foregut and later in adult islet cells. Furthermore, lsl-1 mutations have been identified in type 2 diabetics suggesting that lsl-1 may also play a major role in the etiology of diabetes. While previous studies using isl-1 knockout mice have revealed a vital role for lsl-1 in first wave of endocrine cell differentiation, its role in the second wave of endocrine cell development, in regulation of p-cell function and growth, as well as in adult p-cell expansion have not been addressed due to the early embryonic lethality of lsl-1 deficient mice. We have begun to assess lsl-1 function in second wave of endocrine cell development, p-cell metabolism and p-cell expansion through conditional gene targeting using the Cre/LoxP recombination system. In preliminary work required for this application we have generated and tested all LoxP and Cre mice necessary for the proposed experiments. The specific aims of this proposal are: First, we will determine the role of lsl-1 during second wave of endocrine cell development by using an endoderm-specific ablation of Isl- 1 mouse line. Second, we will investigate the contribution of lsl-1 to p-cell survival and glucose stimulated insulin secretion using a p-cell-specific deletion of lsl-1 mouse line. Third, we will investigate the role of lsl-1 during adult p-cell expansion in to increased metabolic demands of pregnancy, high fat diet feeding and partial pancreatectomy using an inducible Cre-recombinase system. Together these studies will further our understanding of the transcriptional networks controlling the second wave of endocrine cell differentiation, p-cell metabolism, p-cell expansion and the pathogenesis of diabetes. Insights gained from the role of lsl-1 will be used for designing innovative biologically based therapy with the goal to provide novel treatments for diabetes.
|
0.913 |