James E. Rothman
Affiliations: | 1978-1988 | Biochemistry | Stanford University, Palo Alto, CA |
| 1988-1991 | Molecular Biology | Princeton University, Princeton, NJ | |
| 1991-2004 | Cellular Biochemistry and Biophysics | Memorial Sloan-Kettering Cancer Center, Rockville Centre, NY, United States | |
| 2004-2008 | Cellular Biophysics | Columbia University, New York, NY | |
| 2008- | Cell Biology | Yale University, New Haven, CT |
Area:
Secretion, membrane fusionWebsite:
https://www.nobelprize.org/nobel_prizes/medicine/laureates/2013/rothman-bio.htmlGoogle:
"James E. Rothman"Bio:
http://www.nasonline.org/member-directory/members/64187.html
https://medicine.yale.edu/cellbio/people/james_rothman.profile
https://chem.yale.edu/people/james-rothman
https://medicine.yale.edu/lab/rothman/people/james_rothman.profile
Discovered most of the eukaryotic SNARE-mediated membrane fusion machinery
The Nobel Prize in Physiology or Medicine 2013 was awarded jointly to James E. Rothman, Randy W. Schekman and Thomas C. Südhof "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".
Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| Eugene Patrick Kennedy | grad student | 1976 | Harvard Medical School | |
| (Transbilayer asymmetry and its maintenance in biological membranes) | ||||
| Harvey F. Lodish | post-doc | 1976-1978 | MIT | |
Children
Sign in to add trainee| Robert J Johnston | research assistant | (Neurotree) | |
| Con Beckers | grad student | ||
| William G. Dunphy | grad student | Caltech (Chemistry Tree) | |
| Sandra Schmid | grad student | Stanford | |
| John L. R. Rubenstein | grad student | 1980-1982 | Stanford (Neurotree) |
| Benjamin Glick | grad student | 1983-1988 | Stanford |
| Tobias M. Hohl | grad student | 1995-2000 | (Chemistry Tree) |
| Daniel T. Radoff | grad student | 2007-2011 | Columbia (Chemistry Tree) |
| post-doc | (Neurotree) | ||
| Sarah M. Auclair | post-doc | Yale School of Medicine (Chemistry Tree) | |
| William E. Balch | post-doc | Stanford | |
| Frantz Brückert | post-doc | (Chemistry Tree) | |
| Vivek Malhotra | post-doc | Stanford | |
| Gero Miesenbock | post-doc | Memorial Sloan Kettering (Neurotree) | |
| Peggy J. Weidman | post-doc | Princeton (Neurotree) | |
| Ai Yamamoto | post-doc | (Neurotree) | |
| Suzanne R. Pfeffer | post-doc | 1984-1985 | Stanford |
| Michael Brunner | post-doc | 1989-1991 | University of Heidelberg |
| Martin Gerard (Gerry) Waters | post-doc | 1990-1992 | Princeton |
| Sidney W. Whiteheart | post-doc | 1994 | Memorial Sloan-Kettering Cancer Center (Chemistry Tree) |
| Giampietro Schiavo | post-doc | 1996 | Memorial Sloan-Kettering Cancer Center (Neurotree) |
| James A. McNew | post-doc | 1995-2000 | Memorial Sloan-Kettering Cancer Center (Chemistry Tree) |
| Greg Lavieu | post-doc | 2006-2015 | |
| Sathish Ramakrishnan | post-doc | 2015-2019 | (Chemistry Tree) |
| Erdem Karatekin | research scientist | 2008-2011 | Yale (Chemistry Tree) |
BETA: Related publications
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Publications
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| Ramakrishnan S, Bera M, Coleman J, et al. (2020) Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis. Elife. 9 |
| Tagliatti E, Bello OD, Mendonça PRF, et al. (2020) Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release. Proceedings of the National Academy of Sciences of the United States of America |
| Zhang Y, Schroeder LK, Lessard MD, et al. (2020) Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging. Nature Methods |
| Shu T, Jin H, Rothman JE, et al. (2019) Munc13-1 MUN domain and Munc18-1 cooperatively chaperone SNARE assembly through a tetrameric complex. Proceedings of the National Academy of Sciences of the United States of America |
| Rebane AA, Ziltener P, LaMonica LC, et al. (2019) Liquid-Liquid Phase Separation of the Golgi Matrix Protein GM130. Febs Letters |
| Tiwari N, Graham M, Liu X, et al. (2019) Golgin45-Syntaxin5 Interaction Contributes to Structural Integrity of the Golgi Stack. Scientific Reports. 9: 12465 |
| Salpietro V, Dixon CL, Guo H, et al. (2019) AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders. Nature Communications. 10: 3094 |
| Grushin K, Wang J, Coleman J, et al. (2019) Structural basis for the clamping and Ca activation of SNARE-mediated fusion by synaptotagmin. Nature Communications. 10: 2413 |
| Heo P, Ramakrishnan S, Coleman J, et al. (2019) Highly Reproducible Physiological Asymmetric Membrane with Freely Diffusing Embedded Proteins in a 3D-Printed Microfluidic Setup. Small (Weinheim An Der Bergstrasse, Germany). e1900725 |
| Salpietro V, Malintan NT, Llano-Rivas I, et al. (2019) Mutations in the Neuronal Vesicular SNARE VAMP2 Affect Synaptic Membrane Fusion and Impair Human Neurodevelopment. American Journal of Human Genetics |