J. M. Younger, Ph.D.

Protein Folding, Molecular Chaperones, Mitochondria, Intermediate Metabolism

Douglas Cyr	grad student	2006	UNC Chapel Hill
(Selection of misfolded CFTR for proteasomal degradation by sequential quality control checkpoints.)

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Younger JM, Chen L, Ren HY, et al. (2006) Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator. Cell. 126: 571-82
Dai Q, Qian SB, Li HH, et al. (2005) Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. The Journal of Biological Chemistry. 280: 38673-81
Younger JM, Fan CY, Chen L, et al. (2005) Cystic fibrosis transmembrane conductance regulator as a model substrate to study endoplasmic reticulum protein quality control in mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 301: 293-303
Younger JM, Ren HY, Chen L, et al. (2004) A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase. The Journal of Cell Biology. 167: 1075-85
Lee S, Fan CY, Younger JM, et al. (2002) Identification of essential residues in the type II Hsp40 Sis1 that function in polypeptide binding. The Journal of Biological Chemistry. 277: 21675-82
Meacham GC, Patterson C, Zhang W, et al. (2001) The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nature Cell Biology. 3: 100-5