Brent Hartman Cochran, Ph.D.

1985-1993 Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
 1993- Developmental, Molecular, and Chemical Biology Tufts University School of Medicine, Boston, MA, United States 
signal transduction, glioblastoma, Jak/STAT
"Brent Cochran"
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Kulkarni S, Goel S, Sengupta S, et al. (2017) A Large-scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells. Molecular Cancer Research : McR
Sherry-Lynes MM, Sengupta S, Kulkarni S, et al. (2017) Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3. Plos One. 12: e0174775
Goel-Bhattacharya S, Kulkarni S, Sengupta S, et al. (2014) CS-11 * AN RNAi KINOME SCREEN OF GLIOBLASTOMA STEM CELLS UNDER NORMOXIA AND HYPOXIA Neuro-Oncology. 16: v53-v53
Chakraborty S, Li L, Tang H, et al. (2013) Cytoplasmic TRADD confers a worse prognosis in glioblastoma. Neoplasia (New York, N.Y.). 15: 888-97
Sherry MM, Reeves A, Wu JK, et al. (2009) STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells (Dayton, Ohio). 27: 2383-92
Simeone-Penney MC, Severgnini M, Rozo L, et al. (2008) PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L698-704
Konnikova L, Simeone MC, Kruger MM, et al. (2005) Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells. Cancer Research. 65: 6516-20
Konnikova L, Kotecki M, Kruger MM, et al. (2003) Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. Bmc Cancer. 3: 23
Kim DW, Cochran BH. (2001) JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase. Molecular and Cellular Biology. 21: 3387-97
Simon AR, Vikis HG, Stewart S, et al. (2000) Regulation of STAT3 by direct binding to the Rac1 GTPase. Science (New York, N.Y.). 290: 144-7
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