Brent Hartman Cochran, Ph.D.

Affiliations: 
1985-1993 Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
 1993- Developmental, Molecular, and Chemical Biology Tufts University School of Medicine, Boston, MA, United States 
Area:
signal transduction, glioblastoma, Jak/STAT
Website:
www.cochranlab.org
Google:
"Brent Cochran"
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Publications

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Kulkarni S, Goel S, Sengupta S, et al. (2017) A Large-scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells. Molecular Cancer Research : McR
Sherry-Lynes MM, Sengupta S, Kulkarni S, et al. (2017) Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3. Plos One. 12: e0174775
Chakraborty S, Li L, Tang H, et al. (2013) Cytoplasmic TRADD confers a worse prognosis in glioblastoma. Neoplasia (New York, N.Y.). 15: 888-97
Mihaliak AM, Gilbert CA, Li L, et al. (2010) Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres. Cancer Letters. 296: 168-77
Carette JE, Guimaraes CP, Varadarajan M, et al. (2009) Haploid genetic screens in human cells identify host factors used by pathogens. Science (New York, N.Y.). 326: 1231-5
Sherry MM, Reeves A, Wu JK, et al. (2009) STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells (Dayton, Ohio). 27: 2383-92
Simeone-Penney MC, Severgnini M, Rozo L, et al. (2008) PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L698-704
Konnikova L, Simeone MC, Kruger MM, et al. (2005) Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells. Cancer Research. 65: 6516-20
Simon AR, Severgnini M, Takahashi S, et al. (2005) 5-HT induction of c-fos gene expression requires reactive oxygen species and Rac1 and Ras GTPases. Cell Biochemistry and Biophysics. 42: 263-76
Colpoys WE, Cochran BH, Carducci TM, et al. (2005) Shiga toxins activate translational regulation pathways in intestinal epithelial cells. Cellular Signalling. 17: 891-9
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