Jacob E. Lazarus, Ph.D.

2012 Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Cytoskeleton, dynein, cell polarity
"Jacob Lazarus"


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Erika L. F. Holzbaur grad student 2012 Penn
 (Cytoplasmic dynein and dynactin coordinate microtubule dynamics at the growing plus end.)


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Jeffrey J Nirschl collaborator 2014-2015 Penn
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Pacheco AR, Lazarus JE, Sit B, et al. (2018) CRISPR Screen Reveals that EHEC's T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. Mbio. 9
Nirschl JJ, Magiera MM, Lazarus JE, et al. (2016) α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons. Cell Reports
Thom CS, Traxler EA, Khandros E, et al. (2014) Trim58 degrades Dynein and regulates terminal erythropoiesis. Developmental Cell. 30: 688-700
Ayloo S, Lazarus JE, Dodda A, et al. (2014) Dynactin functions as both a dynamic tether and brake during dynein-driven motility. Nature Communications. 5: 4807
Perlson E, Hendricks AG, Lazarus JE, et al. (2013) Dynein interacts with the neural cell adhesion molecule (NCAM180) to tether dynamic microtubules and maintain synaptic density in cortical neurons. The Journal of Biological Chemistry. 288: 27812-24
Moughamian AJ, Osborn GE, Lazarus JE, et al. (2013) Ordered recruitment of dynactin to the microtubule plus-end is required for efficient initiation of retrograde axonal transport. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13190-203
Lazarus JE, Moughamian AJ, Tokito MK, et al. (2013) Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor. Plos Biology. 11: e1001611
Zhang J, Twelvetrees AE, Lazarus JE, et al. (2013) Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions. Cytoskeleton (Hoboken, N.J.). 70: 215-27
Lazarus JE, Moughamian AJ, Tokito MK, et al. (2013) p150Glued Regulates Microtubule Dynamics in Neurons through Tandem Tubulin-Binding Domains Biophysical Journal. 104: 146a
Hendricks AG, Lazarus JE, Perlson E, et al. (2012) Dynein tethers and stabilizes dynamic microtubule plus ends. Current Biology : Cb. 22: 632-7
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