Stephen S. Taylor, Ph.D.
Affiliations: | 1992-1995 | Biochemistry | University of Oxford, Oxford, United Kingdom |
| 1995-1998 | Cell Biology | Harvard Medical School, Boston, MA, United States | |
| 1998-2015 | Faculty of Life Sciences | University of Manchester, Manchester, England, United Kingdom | |
| 2015- | Manchester Cancer Research Centre | University of Manchester, Manchester, England, United Kingdom |
Area:
Cell division, mitosis, spindle assembly checkpoint, anti-mitotic chemotherapeuticsWebsite:
http://www.bub1.comGoogle:
"stephen taylor manchester"Bio:
Parents
Sign in to add mentor| Edwin M. Southern | grad student | 1992-1995 | Oxford (Neurotree) |
| Frank McKeon | post-doc | 1995-1998 | Harvard Medical School |
Children
Sign in to add trainee| Andrew J. Holland | grad student | 2003-2006 | Johns Hopkins Medical School |
| Karen E. Gascoigne | grad student | 2005-2008 | University of Manchester |
| Frederick G. Westhorpe | grad student | 2008-2011 | University of Manchester |
| Pablo Lara-Gonzalez | grad student | 2008-2012 | University of Manchester |
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Publications
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| Amalina I, Bennett A, Whalley H, et al. (2021) Inhibitors of the Bub1 spindle assembly checkpoint kinase: synthesis of BAY-320 and comparison with 2OH-BNPP1. Royal Society Open Science. 8: 210854 |
| Todd S, Todd P, McGowan SJ, et al. (2020) CSynth: An Interactive Modelling and Visualisation Tool for 3D Chromatin Structure. Bioinformatics (Oxford, England) |
| Nelson L, Tighe A, Golder A, et al. (2020) A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity. Nature Communications. 11: 822 |
| Littler S, Sloss O, Geary B, et al. (2019) Oncogenic MYC amplifies mitotic perturbations. Open Biology. 9: 190136 |
| Pillay N, Tighe A, Nelson L, et al. (2019) DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell. 35: 519-533.e8 |
| Simões-Sousa S, Littler S, Thompson SL, et al. (2018) The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α. Cell Reports. 25: 749-760.e6 |
| Sloss O, Topham C, Diez M, et al. (2017) Mcl-1 dynamics influence mitotic slippage and death in mitosis. Oncotarget. 7: 5176-92 |
| Bennett A, Sloss O, Topham C, et al. (2016) Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers. Open Biology. 6 |
| Davies JO, Telenius JM, McGowan SJ, et al. (2015) Multiplexed analysis of chromosome conformation at vastly improved sensitivity. Nature Methods |
| Aspinall CF, Zheleva D, Tighe A, et al. (2015) Mitotic entry: Non-genetic heterogeneity exposes the requirement for Plk1. Oncotarget |