Samanthi A. Perera, Ph.D.

2003 Brandeis University, Waltham, MA, United States 
Molecular Biology
"Samanthi Perera"


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Ruibao Ren grad student 2003 Brandeis
 (A mutational analysis of BCR /ABL and TEL /ABL in leukemogenesis.)
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Shimamura T, Perera SA, Foley KP, et al. (2012) Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 4973-85
Kim WY, Perera S, Zhou B, et al. (2009) HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. The Journal of Clinical Investigation. 119: 2160-70
Perera SA, Li D, Shimamura T, et al. (2009) HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proceedings of the National Academy of Sciences of the United States of America. 106: 474-9
Kim WY, Perera S, Zhou B, et al. (2009) HIF2α cooperates with RAS to promote lung tumorigenesis in mice (Journal of Clinical Investigation (2009) 119, (2160-2170) doi:101172/JCI38443) Journal of Clinical Investigation. 119: 3182
Engelman JA, Chen L, Tan X, et al. (2008) Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nature Medicine. 14: 1351-6
Shimamura T, Li D, Ji H, et al. (2008) Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Research. 68: 5827-38
Perera SA, Maser RS, Xia H, et al. (2008) Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis. 29: 747-53
Ji H, Ramsey MR, Hayes DN, et al. (2007) LKB1 modulates lung cancer differentiation and metastasis. Nature. 448: 807-10
Li D, Shimamura T, Ji H, et al. (2007) Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell. 12: 81-93
Wertheim JA, Perera SA, Hammer DA, et al. (2003) Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development. Blood. 102: 2220-8
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