Bret D. Freudenthal, Ph.D.

2010 Biochemistry University of Iowa, Iowa City, IA 
Cell Biology, Biochemistry
"Bret Freudenthal"


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M. Todd Washington grad student 2010 University of Iowa
 (Studies of proliferating cell nuclear antigen and its role in translesion synthesis.)
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Smith MR, Alnajjar KS, Hoitsma NM, et al. (2019) Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β. The Journal of Biological Chemistry
McNeill DR, Whitaker AM, Stark WJ, et al. (2019) Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance. Mutagenesis
Hoitsma NM, Whitaker AM, Schaich MA, et al. (2019) Structure and function relationships in mammalian DNA polymerases. Cellular and Molecular Life Sciences : Cmls
Akakpo JY, Ramachandran A, Duan L, et al. (2019) Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase. Toxicological Sciences : An Official Journal of the Society of Toxicology
Smith MR, Shock DD, Beard WA, et al. (2019) A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Research
Whitaker AM, Freudenthal BD. (2018) APE1: A skilled nucleic acid surgeon. Dna Repair
Fairlamb MS, Whitaker AM, Freudenthal BD. (2018) Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallographica. Section D, Structural Biology. 74: 760-768
Whitaker AM, Flynn TS, Freudenthal BD. (2018) Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nature Communications. 9: 399
Bastola P, Wang F, Schaich MA, et al. (2017) Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors. Cell Death Discovery. 3: 17065
Schaich MA, Smith MR, Cloud AS, et al. (2017) Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues. Chemical Research in Toxicology
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