Martin Gerard (Gerry) Waters

1991-2002 Molecular Biology Princeton University, Princeton, NJ 
 2010- Novartis Institute for BioMedical Research 
"Martin Gerard Waters"

Post-doctoral fellow: Princeton University January 1989 – July 1990, Sloan Kettering Institute August 1990 – March 1991


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Günter Blobel grad student 1988 Rockefeller
 (Protein translocation into the endoplasmic reticulum of yeast: a biochemical analysis.)
James E. Rothman post-doc 1990-1992 Princeton


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Bryan A. Kraynack grad student 2003 Princeton
Vladimir Lupashin post-doc 1995-1998 Princeton
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Strack AM, Carballo-Jane E, Wang SP, et al. (2013) Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis. Journal of Lipid Research. 54: 177-88
Lauring B, Taggart AK, Tata JR, et al. (2012) Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Science Translational Medicine. 4: 148ra115
Boatman PD, Lauring B, Schrader TO, et al. (2012) (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. Journal of Medicinal Chemistry. 55: 3644-66
Imbriglio JE, DiRocco D, Bodner R, et al. (2011) The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties. Bioorganic & Medicinal Chemistry Letters. 21: 2721-4
Jensen KK, Geoghagen NS, Jin L, et al. (2011) Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice. European Journal of Pharmacology. 650: 86-93
Imbriglio JE, Chang S, Liang R, et al. (2010) GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorganic & Medicinal Chemistry Letters. 20: 4472-4
Schmidt D, Smenton A, Raghavan S, et al. (2010) Anthranilic acid replacements in a niacin receptor agonist. Bioorganic & Medicinal Chemistry Letters. 20: 3426-30
Shen HC, Ding FX, Raghavan S, et al. (2010) Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. Journal of Medicinal Chemistry. 53: 2666-70
Shen HC, Ding FX, Deng Q, et al. (2009) Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats. Journal of Medicinal Chemistry. 52: 2587-602
Lai E, Waters MG, Tata JR, et al. (2008) Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans. Journal of Clinical Lipidology. 2: 375-83
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