Heather True

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Molecular Biology
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"Heather True"
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Findlay AR, Paing MM, Daw JA, et al. (2023) DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1. Molecular Therapy. Nucleic Acids. 32: 937-948
Bhadra AK, Rau MJ, Daw JA, et al. (2022) Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors. Nature Communications. 13: 4570
Pullen MY, Weihl CC, True HL. (2020) Client processing is altered by novel myopathy-causing mutations in the HSP40 J domain. Plos One. 15: e0234207
Bengoechea R, Findlay AR, Bhadra AK, et al. (2020) Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy. The Journal of Clinical Investigation
Arthur LL, Chung JJ, Janakirama P, et al. (2017) Corrigendum: Rapid generation of hypomorphic mutations. Nature Communications. 8: 14705
Arthur LL, Chung JJ, Jankirama P, et al. (2017) Rapid generation of hypomorphic mutations. Nature Communications. 8: 14112
Keefer KM, True HL. (2016) Prion-Associated Toxicity is Rescued by Elimination of Cotranslational Chaperones. Plos Genetics. 12: e1006431
Stein KC, True HL. (2014) Structural variants of yeast prions show conformer-specific requirements for chaperone activity. Molecular Microbiology. 93: 1156-71
Stein KC, Bengoechea R, Harms MB, et al. (2014) Myopathy-causing mutations in an HSP40 chaperone disrupt processing of specific client conformers. The Journal of Biological Chemistry. 289: 21120-30
Stein KC, True HL. (2014) Extensive diversity of prion strains is defined by differential chaperone interactions and distinct amyloidogenic regions. Plos Genetics. 10: e1004337
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