Frederic Sigoillot, Ph.D.
Affiliations: | 2005 | Wayne State University, Detroit, MI, United States |
Area:
Biochemistry, Cell Biology, Molecular BiologyGoogle:
"Frederic Sigoillot"Parents
Sign in to add mentor| Hedeel I. Evans | grad student | 2005 | Wayne State | |
| (Phosphorylation of the multifunctional protein CAD by MAP kinase, PKA and PKC cascades leads to the cellular control of de novo pyrimidine biosynthesis and is associated with differential localizations of CAD.) | ||||
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Publications
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| Zeng H, Castillo-Cabrera J, Manser M, et al. (2019) Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. Elife. 8 |
| Leung GP, Feng T, Sigoillot FD, et al. (2018) Hyperactivation of MAPK Signaling is Deleterious to RAS/RAF Mutant Melanoma. Molecular Cancer Research : McR |
| Sackton KL, Dimova N, Zeng X, et al. (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 514: 646-9 |
| Lim HJ, Dimova NV, Tan MK, et al. (2013) The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. Molecular and Cellular Biology. 33: 4166-80 |
| Zeng X, Sigoillot F, Gaur S, et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18: 382-95 |
| Sigoillot FD, Kotsis DH, Masko EM, et al. (2007) Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase. Frontiers in Bioscience : a Journal and Virtual Library. 12: 3892-8 |
| Kotsis DH, Masko EM, Sigoillot FD, et al. (2007) Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade. Molecular and Cellular Biochemistry. 301: 69-81 |
| Sigoillot FD, Kotsis DH, Serre V, et al. (2005) Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. The Journal of Biological Chemistry. 280: 25611-20 |
| Sigoillot FD, Sigoillot SM, Guy HI. (2004) Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells. International Journal of Cancer. Journal International Du Cancer. 109: 491-8 |
| Sigoillot FD, Berkowski JA, Sigoillot SM, et al. (2003) Cell cycle-dependent regulation of pyrimidine biosynthesis. The Journal of Biological Chemistry. 278: 3403-9 |