Thomas D. Hurley

Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Molecular Biology, Biochemistry
"Thomas Hurley"
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Huddle BC, Grimley E, Chtcherbinine M, et al. (2020) Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy. European Journal of Medicinal Chemistry. 211: 113060
Tang B, Frasinyuk MS, Chikwana VM, et al. (2020) Discovery and development of small-molecule inhibitors of glycogen synthase. Journal of Medicinal Chemistry
Chefetz I, Grimley E, Yang K, et al. (2019) A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Reports. 26: 3061-3075.e6
Huddle BC, Grimley E, Buchman CD, et al. (2018) Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy. Journal of Medicinal Chemistry
Buchman CD, Hurley TD. (2017) Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives. Journal of Medicinal Chemistry
Mahalingan KK, Baskaran S, Depaoli-Roach AA, et al. (2016) Redox switch for the inhibited state of yeast glycogen synthase mimics regulation by phosphorylation. Biochemistry
Contreras CJ, Segvich DM, Mahalingan K, et al. (2016) Incorporation of phosphate into glycogen by glycogen synthase. Archives of Biochemistry and Biophysics
Buchman CD, Mahalingan KK, Hurley TD. (2015) Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors. Chemico-Biological Interactions. 234: 38-44
Morgan CA, Hurley TD. (2015) Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. Journal of Medicinal Chemistry. 58: 1964-75
Morgan CA, Parajuli B, Buchman CD, et al. (2015) N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. Chemico-Biological Interactions. 234: 18-28
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