Jennifer A. Digits, Ph.D.

Affiliations: 
2000 Brandeis University, Waltham, MA, United States 
Area:
Biochemistry
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"Jennifer Digits"

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Lizbeth Hedstrom grad student 2000 Brandeis
 (A structural and kinetic analysis of IMP dehydrogenase: Implications for mycophenolic acid selectivity.)
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Kung PP, Huang B, Zhang G, et al. (2010) Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone. Journal of Medicinal Chemistry. 53: 499-503
Digits JA, Pyun HJ, Coates RM, et al. (2002) Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. The Journal of Biological Chemistry. 277: 41086-93
Beigneux A, Withycombe SK, Digits JA, et al. (2002) Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. The Journal of Biological Chemistry. 277: 38358-63
Tschantz WR, Digits JA, Pyun HJ, et al. (2001) Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. The Journal of Biological Chemistry. 276: 2321-4
Kerr KM, Digits JA, Kuperwasser N, et al. (2000) Asp338 controls hydride transfer in Escherichia coli IMP dehydrogenase. Biochemistry. 39: 9804-10
Digits JA, Hedstrom L. (2000) Drug selectivity is determined by coupling across the NAD+ site of IMP dehydrogenase. Biochemistry. 39: 1771-7
Digits JA, Hedstrom L. (1999) Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid. Biochemistry. 38: 15388-97
Digits JA, Hedstrom L. (1999) Kinetic mechanism of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase. Biochemistry. 38: 2295-306
Eldin S, Digits JA, Huang ST, et al. (1995) Lifetime of an aliphatic iminium ion in aqueous solution Journal of the American Chemical Society. 117: 6631-6632
Kondepudi DK, Bullock KL, Digits JA, et al. (1995) Stirring rate as a critical parameter in chiral symmetry breaking crystallization Journal of the American Chemical Society. 117: 401-404
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