Michael A. Kalwat, Ph.D.

2007-2012 Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
 2012- Pharmacology University of Texas Southwester Medical Center, Dallas, TX, United States 
Diabetes, Islet Biology, regulation of hormone secretion
"Michael Kalwat"


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James D. Forney research assistant Purdue (Chemistry Tree)
Debbie C. Thurmond grad student 2012 Indiana University
 (F-actin regulation of snare-mediated insulin secretion.)
Melanie Cobb post-doc 2012- University of Texas Southwester Medical Center (FlyTree)
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Kalwat MA, Huang Z, Binns DD, et al. (2020) α-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. Frontiers in Cell and Developmental Biology. 8: 576396
Hernandez G, Luo T, Javed TA, et al. (2020) Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy. Science Translational Medicine. 12
Kalwat M, Cobb MH. (2019) Measuring Relative Insulin Secretion using a Co-Secreted Luciferase Surrogate. Journal of Visualized Experiments : Jove
Kalwat MA, Hwang IH, Macho J, et al. (2018) Chromomycin A potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. The Journal of General Physiology
Kalwat MA, Wichaidit C, Nava Garcia AY, et al. (2017) Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways. Acs Sensors. 2: 316
Kalwat MA, Cobb M. (2017) Mechanisms of the Amplifying Pathway of Insulin Secretion in the β Cell. Pharmacology & Therapeutics
Guerra ML, Kalwat MA, McGlynn K, et al. (2017) Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. Febs Open Bio. 7: 174-186
Kalwat MA, Wichaidit C, Nava Garcia AY, et al. (2016) Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways. Acs Sensors. 1: 1208-1212
Kalwat MA, Huang Z, Wichaidit C, et al. (2016) Isoxazole alters metabolites and gene expression, decreasing proliferation and promoting a neuroendocrine phenotype in β-cells. Acs Chemical Biology
Kalwat MA, Thurmond DC. (2013) Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells. Experimental & Molecular Medicine. 45: e37
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