Michael A. Kalwat, Ph.D.

Affiliations: 
2007-2012 Biochemistry and Molecular Biology Indiana University, Bloomington, Bloomington, IN, United States 
Area:
Biochemistry, Molecular Biology
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"Michael Kalwat"

Parents

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Debbie C. Thurmond grad student 2012 Indiana University
 (F-actin regulation of snare-mediated insulin secretion.)
Melanie Cobb post-doc 2012- University of Texas Southwester Medical Center (FlyTree)
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Publications

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Kalwat MA, Hwang IH, Macho J, et al. (2018) Chromomycin A potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. The Journal of General Physiology
Kalwat MA, Cobb M. (2017) Mechanisms of the Amplifying Pathway of Insulin Secretion in the β Cell. Pharmacology & Therapeutics
Guerra ML, Kalwat MA, McGlynn K, et al. (2017) Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. Febs Open Bio. 7: 174-186
Kalwat MA, Wichaidit C, Nava Garcia AY, et al. (2016) Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways. Acs Sensors. 1: 1208-1212
Kalwat MA, Huang Z, Wichaidit C, et al. (2016) Isoxazole alters metabolites and gene expression, decreasing proliferation and promoting a neuroendocrine phenotype in β-cells. Acs Chemical Biology
Kalwat MA, Thurmond DC. (2013) Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells. Experimental & Molecular Medicine. 45: e37
Kalwat MA, Yoder SM, Wang Z, et al. (2013) A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells. Biochemical Pharmacology. 85: 808-16
Ramalingam L, Oh E, Yoder SM, et al. (2012) Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity. Diabetes. 61: 2424-32
Oh E, Kalwat MA, Kim MJ, et al. (2012) Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms. The Journal of Biological Chemistry. 287: 25821-33
Kalwat MA, Wiseman DA, Luo W, et al. (2012) Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis. Molecular Endocrinology (Baltimore, Md.). 26: 128-41
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