Daniel F. Gaddy, Ph.D.

2006 Wake Forest University, Winston-Salem, NC, United States 
Microbiology Biology
"Daniel Gaddy"


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Douglas S. Lyles grad student 2006 Wake Forest
 (Analysis of host gene products that contribute to the induction of apoptosis by oncolytic vesicular stomatitis virus.)
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Geretti E, Leonard SC, Dumont N, et al. (2015) Cyclophosphamide-mediated tumor priming for enhanced delivery and anti-tumor activity of HER2-targeted liposomal doxorubicin (MM-302). Molecular Cancer Therapeutics
Gaddy DF, Lee H, Zheng J, et al. (2015) Whole-body organ-level and kidney micro-dosimetric evaluations of (64)Cu-loaded HER2/ErbB2-targeted liposomal doxorubicin ((64)Cu-MM-302) in rodents and primates. Ejnmmi Research. 5: 24
Tilstra JS, Gaddy DF, Zhao J, et al. (2014) Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death. Scientific Reports. 4: 3631
Hendriks BS, Klinz SG, Reynolds JG, et al. (2013) Impact of tumor HER2/ERBB2 expression level on HER2-targeted liposomal doxorubicin-mediated drug delivery: multiple low-affinity interactions lead to a threshold effect. Molecular Cancer Therapeutics. 12: 1816-28
Gaddy DF, Riedel MJ, Bertera S, et al. (2012) dsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice. Gene Therapy. 19: 791-9
Gaddy DF, Riedel MJ, Pejawar-Gaddy S, et al. (2010) In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/db mouse model of diabetes. Diabetes. 59: 3108-16
Pejawar-Gaddy S, Rajawat Y, Hilioti Z, et al. (2010) Generation of a tumor vaccine candidate based on conjugation of a MUC1 peptide to polyionic papillomavirus virus-like particles. Cancer Immunology, Immunotherapy : Cii. 59: 1685-96
Riedel MJ, Gaddy DF, Asadi A, et al. (2010) DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes. Gene Therapy. 17: 171-80
Gaddy DF, Robbins PD. (2008) Current status of gene therapy for rheumatoid arthritis Current Rheumatology Reports. 10: 398-404
Gaddy DF, Lyles DS. (2007) Oncolytic vesicular stomatitis virus induces apoptosis via signaling through PKR, Fas, and Daxx Journal of Virology. 81: 2792-2804
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