Suzanna L. Bailey, Ph.D.

Affiliations: 
2010 Wake Forest University, Winston-Salem, NC, United States 
Area:
Biochemistry, Molecular Biology, Immunology
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"Suzanna Bailey"

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Thomas Hollis grad student 2010 Wake Forest
 (The TREX1 3' exonuclease and autoimmune disease: Structural and biochemical analysis of disease mutants involved in autoimmune dysfunction.)
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Publications

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Darman RB, Seiler M, Agrawal AA, et al. (2015) Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3? Splice Site Selection through Use of a Different Branch Point. Cell Reports. 13: 1033-1045
Bailey SL, Harvey S, Perrino FW, et al. (2012) Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. Dna Repair. 11: 65-73
Lee-Kirsch MA, Gong M, Chowdhury D, et al. (2007) Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nature Genetics. 39: 1065-7
de Silva U, Choudhury S, Bailey SL, et al. (2007) The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. The Journal of Biological Chemistry. 282: 10537-43
Buchmueller KL, Bailey SL, Matthews DA, et al. (2006) Physical and structural basis for the strong interactions of the -ImPy- central pairing motif in the polyamide f-ImPyIm. Biochemistry. 45: 13551-65
Buchmueller KL, Taherbhai Z, Howard CM, et al. (2005) Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene. Chembiochem : a European Journal of Chemical Biology. 6: 2305-11
Buchmueller KL, Staples AM, Uthe PB, et al. (2005) Molecular recognition of DNA base pairs by the formamido/pyrrole and formamido/imidazole pairings in stacked polyamides. Nucleic Acids Research. 33: 912-21
Buchmueller KL, Horick SM, Howard CM, et al. (2005) Recognition of specific DNA sequences by stacked pyrrole- and imidazole-containing polyamides: An efficient screening method based on competitive dialysis Letters in Drug Design and Discovery. 2: 137-142
Uthe PB, Staples AM, Turlington M, et al. (2005) Novel picolinic acid-containing pyrrole-imidazole polyamides: Synthesis and T·G mismatched base pair recognition Heterocyclic Communications. 11: 163-166
Henry JA, Le NM, Nguyen B, et al. (2004) Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies. Biochemistry. 43: 12249-57
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