Annissa J. Huhn, Ph.D.

Affiliations: 
2012 Biochemistry and Molecular Biology Wake Forest University, Winston-Salem, NC, United States 
Area:
Biochemistry
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"Annissa Huhn"

Parents

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Thomas Hollis grad student 2012 Wake Forest
 (Elucidating the ferritin-high molecular weight kininogen domain 5 interaction.)
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Publications

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Wilson JE, Patel G, Patel C, et al. (2020) Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor. Acs Medicinal Chemistry Letters. 11: 1324-1329
Harvey EP, Hauseman ZJ, Cohen DT, et al. (2020) Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology
Wilson JE, Huhn A, Gardberg AS, et al. (2020) Early Drug Discovery Efforts Towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors. Chemmedchem
Gardberg AS, Huhn AJ, Cummings R, et al. (2019) Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT. Structural Dynamics (Melville, N.Y.). 6: 054702
Bommi-Reddy A, Wilson J, Huhn AJ, et al. (2019) Abstract 4722: Efficacy of a novel EP300/CBP histone acetyltransferase inhibitor in hormone responsive breast cancer Cancer Research. 79: 4722-4722
Guerra RM, Huhn AJ, Harvey EP, et al. (2017) Abstract 2024: Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors Cancer Research. 77: 2024-2024
Huhn AJ, Guerra RM, Harvey EP, et al. (2016) Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors. Cell Chemical Biology
Lee S, Wales TE, Escudero S, et al. (2016) Allosteric inhibition of antiapoptotic MCL-1. Nature Structural & Molecular Biology
Huhn AJ, Guerra RM, Bird GH, et al. (2016) Abstract 3845: A novel selectivity determinant informs the development of next-generation stapled peptide inhibitors of anti-apoptotic BFL-1/A1 Cancer Research. 76: 3845-3845
Lee S, Wales TE, Gallagher C, et al. (2016) Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1 Cancer Research. 76: 3553-3553
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