Aron B. Jaffe, Ph.D.

Affiliations: 
2000 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Genetics, Molecular Biology
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"Aron Jaffe"

Parents

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Thomas A. Jongens grad student 2000 Penn
 (Molecular and genetic characterization of two DNA replication accessory factors in Drosophila.)
Allon M. Klein research scientist
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Publications

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Danahay H, Pessotti AD, Coote J, et al. (2015) Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. Cell Reports. 10: 239-52
Persson BD, Jaffe AB, Fearns R, et al. (2014) Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. Plos One. 9: e102368
Zhan L, Rosenberg A, Bergami KC, et al. (2008) Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell. 135: 865-78
Jaffe AB, Kaji N, Durgan J, et al. (2008) Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. The Journal of Cell Biology. 183: 625-33
Merdek KD, Jaffe AB, Dutt P, et al. (2008) Alpha(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent. Biochemical and Biophysical Research Communications. 366: 717-23
Jaffe AB, Hall A. (2005) Rho GTPases: biochemistry and biology. Annual Review of Cell and Developmental Biology. 21: 247-69
Jaffe AB, Hall A, Schmidt A. (2005) Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. Current Biology : Cb. 15: 405-12
Dutt P, Jaffe AB, Merdek KD, et al. (2004) Galphaz inhibits serum response factor-dependent transcription by inhibiting Rho signaling. Molecular Pharmacology. 66: 1508-16
Jaffe AB, Aspenström P, Hall A. (2004) Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Molecular and Cellular Biology. 24: 1736-46
Jaffe AB, Hall A. (2003) Cell biology. Smurfing at the leading edge. Science (New York, N.Y.). 302: 1690-1
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